Antiseptic and analgesic therapeutic agent in form of gel for processing and lubricating catheters used in examining and treating urogenital system

FIELD: medicine.

SUBSTANCE: therapeutic agent contains hypromellose, boric acid and a consistency base; it additionally contains anesthesin or lidocaine as an analgesic in an amount of 0.00001-0.5 g.

EFFECT: fixing a lubricating agent on the catheter enabling preventing mucosal injuries accompanying a drainage procedure, and eliminating side effects.

3 cl, 6 ex

 

The invention relates to medicine, namely to medicines in the form of a gel for processing and lubrication of the catheter during the examination and treatment of the urogenital system.

The catheter is a common medical instrument representing a hollow tube that serves to compose the natural channels of the body cavities, blood vessels with the external environment with the purpose of emptying, the introduction of a fluid, lavage, or conduction through them surgical instruments. Are various modifications of the elastic urethral catheters. Holding the catheter through the urethra into the bladder is always associated with some risk of damage to the mucosa of the urinary tract. Traumatic when conducting drainage in the male the urethra due to the high risk of penile injuries and bulbosus part of the urethra due to the specific structure of the wall of the urethra and its anatomical curves. Significantly reduces the risk of such complications, the use of special lubrication to reduce friction when carrying out drainage through the urethra through the creation of a sufficient layer film of lubricant between them.

Known application in our country as lubricants for catheterization of sterile liquid paraffin (mineral oil) because of its low cost and wide availability. In some cases the known lubricants - liniment of syntomycin, metiluratsilovoy ointment and levomicol.

(http://www.neurourologist.ru/vidy_kateter/)

It is widely known use as lubricants for intermittent catheterization sterile glycerol, vaseline oil or sunflower oil.

(medicina-online.ru/med/44862/)

General shortcomings described above and others known and used in modern medicine lubricants for catheterization is the fact that they are not evenly grease the surface of the mucous membrane of the urethra, causing adverse reactions (allergies),and applied to the catheter is not fixed on it, and therefore erased from the catheter and remain in the external part of the urethra.

The objective of the invention is the creation of antiseptic and analgesic drugs in the form of a gel for processing and lubrication of the catheter during the examination and treatment of the urogenital system, providing a painless process of drainage and uniform coating on the catheter.

The technical result, which directed the establishment of this invention is durable fixation of lubricant on the catheter, allowing the carrying out of drainage to prevent injury to the mucous membrane, and also to eliminate adverse reactions (allergies).

This technical result is achieved by the fact that antiseptic and analgesic l the drug means in the form of a gel for processing and lubrication of the catheter during the examination and treatment of the urogenital system according to the invention contains hypromellose, boric acid and consistantness the basis of the following ratio of components in g per 1 ml of a mixture of:

hypromellosewithin 0.00001 to 0.5
boric acidwithin 0.00001 to 0.5
consistentarea baserest

In addition, the drug contains benzocaine or lidocaine as an anesthetic in the amount within 0.00001 to 0.5,

As well as pharmaceutically acceptable bases contains macrogol 400, or macrogol 1500, or macrogol 4000.

Spent an analysis of the prior art, including searching by the patent and scientific and technical information sources, and identify sources that contain information about the equivalents of the claimed medicinal product, has allowed to establish that the petitioners have not found a similar, characterized by signs, identical to all the essential features of the claimed means.

The definition from the list of identified analogues revealed a set of essential in relation to perceived technical result of the distinctive features in the claimed medicinal product set forth in the claims.

Therefore, the claimed Le is arctonoe tool meets the criterion of “novelty.”

For verification of the compliance of medicines prior art, the applicants conducted an additional search of the known solutions, in order to identify the signs consistent with the known characteristics of the claimed invention.

The search results showed that the claimed invention not apparent to the expert in the obvious way from the prior art, certain applicants have identified no impact envisaged the essential features of the claimed medicinal product transformations to achieve a technical result.

Therefore, the claimed invention meets the criterion of “inventive step”.

The criteria of the invention “industrial applicability” is confirmed by the fact that the claimed medicinal product provides painless process of drainage and uniform coating of the lubricant on the catheter, and durable fixation of lubricant on the catheter, allowing the carrying out of drainage to prevent injury to the mucous membrane, and also to eliminate adverse reactions (allergies).

The present invention is illustrated with specific examples of implementation, which, however, are not only possible, but clearly demonstrate the possibility of achieving the desired technical result.

Example 1. To get the drug what about the funds in the form of gel mix hypromellose, boric acid and macrogol 400 in the following ratio of components in g per 1 ml of a mixture of:

Options:1234
hypromellose0,000010,00010,0010,5
boric acid0,50,0010,00010,00001
macrogol 400the rest is up to 1 ml

Example 2. Carried out analogously to example 1. Except that the drugs are additionally contains benzocaine in number within 0.00001-0.5 g and macrogol 1500.

Example 3. Carried out analogously to example 1. Except that it additionally contains lidocaine in number within 0.00001-0.5 g and macrogol 4000.

Example 4. Patient G., 62, entered MBUS GKB №18, Ufa with a diagnosis of burn IIIB-IV degree torso 9%. After operations how agressively to debride and autodermoplastiki on the 6th day of receipt after 6 hours are diagnosed with acute urinary retention. The bladder is palpated, marked N. Prairie, the upper pole is located 2-3 cm below the navel. Decided to catheterization of the bladder soft Foley catheter. After pre-processing the head of the penis with antiseptic solution and lubrication of the catheter of the medicinal product in example 1 was released 900 ml light yellow urine without impurities and traces of blood. After the procedure, the catheter is removed. Infection and complications, as well as complaints from the patient was not.

Example 5. Patient K., 23 years enrolled in BUS GKB №18, Ufa with a diagnosis of burn II-IIIAB-IV degree torso, the right lower limb 22% (19%). Shock severe. Upon receipt produced catheterization of the right subclavian vein, installed nasogastric gastric tube and soft Foley catheter. Within three days the urine was carried out by the catheter. After the stabilization and normalization of hemodynamics and transfer for treatment on fluidizers installation of SAT-1 has changed the urinary catheter. Pre catheters were treated with the medication in the form of a gel according to example 2.

Infection and complications, as well as complaints from the patient was not. Clinic ordinary postcatheterization urethritis was not determined. In the analysis of urine after removal of the catheter blood was not determined.

Example 6. Patient Y., 76 years old, he enrolled in BUS GKB №18, Ufa with diagnose is: burn II-IIIA degree torso, the perineum, thighs 8%. Injury in the home, hot water. When entering the field of burns moderate swelling, detachment of the epidermis, vesicles with serous clear content. On the second day after injury showed a pronounced swelling of the penis and scrotum. The patient began to Lodge complaints during urination. for planned surgical treatment regarding post-burn scar contractures of the right shoulder joint. After the surgery, on the second day appeared fever up to 38°C. Complaints of General malaise, weakness, pain in the surgical wound. Later hyperemia in the crotch area, itching and burning during urination.

Decided to catheterization of the bladder soft Foley catheter. After pre-processing the head of the penis with antiseptic solution and lubrication of the catheter of the medicinal product in the form of a gel according to example 3. Released 700 ml light yellow light of urine without impurities and traces of blood. After the procedure, the catheter is removed.

In subsequent repeated urinary retention after 6 hours, it was decided to perform catheterization of the bladder of the patient constantly. After pre-processing the head of the penis with antiseptic solution and lubrication of the catheter of the medicinal product in the form of a gel according to example 2. In the process of the treatment and care of urinary catheter treatment of the glans penis and distal part of the catheter was performed by gel. When testing urine signs of damage to the urethra is not defined. On the 14th day after the injury marked the process of epithelialization of burn wounds, reducing swelling, reducing the signs of inflammation, removal of the catheter. After restoration of spontaneous urination no complaints and infection. Abnormal discharge from the urethra was not.

The patient was discharged on the 21st day in a satisfactory condition.

Thus, the claimed antiseptic and analgesic drug in the form of a gel for processing and lubrication of the catheter during the examination and treatment of the urogenital system is a highly effective tool that provides a painless process of drainage and uniform coating of the lubricant on the catheter, and durable fixation of lubricant on the catheter, allowing the carrying out of drainage to prevent injury to the mucous membrane, and also to eliminate adverse reactions (allergies).

1. Antiseptic drug in the form of a gel for processing and lubrication of the catheter during the examination and treatment of the urogenital system, characterized in that it contains hypromellose, boric acid and consistantness the basis of the following ratio of components in g per 1 ml of a mixture of:

hypromellosewithin 0.00001 to 0.5
boric acidwithin 0.00001 to 0.5
consistentarea baserest

2. Antiseptic drug under item 1, characterized in that it further includes benzocaine or lidocaine as an anesthetic in the amount within 0.00001 to 0.5,

3. Antiseptic drug on PP. 1-2, characterized in that as consistentarea framework contains macrogol 400, or macrogol 1500, or macrogol 4000.



 

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