Method for blood pressure normalisation

FIELD: medicine.

SUBSTANCE: pulse electric activity of sensorimotor central neurons is recorded in experimental animals adapted to hypoxia. The recorded activity frequency is modulated by a multivibrator and an electroacoustic transducer; the signals are copied and transferred onto a carrier. The patient is exposed to distant acoustic signals with the use of the laser generator. The exposure is sequential and starts with sessions at frequency 5-8 Hz for 5-7 minutes and follows with sessions at frequency 10-15 Hz for 5-8 minutes. The sessions are daily, one session a day; the therapeutic course is 10-14 sessions.

EFFECT: method enables using the drug-free modalities and normalise the blood pressure that is ensured by providing the mode and sequence of acoustic signal flow.

2 tbl, 3 ex

 

The invention relates to medicine and can be used in cardiology, clinical, aviation, space medicine.

There is a method of lowering blood pressure in the treatment of hypertension in patent RU 2196628, which includes a course of sessions remote effects on the body by the combined use dosed physical load and high gravity craniocaudal direction. For implementing the method using a centrifuge with a vertical axis of rotation on a horizontal platform which placed the patient with the head in the center of the axis of rotation, and the limb on the periphery. The rotational speed of the centrifuge is in the range from 0 to 45 revolutions per minute. To perform the muscle load on the platform centrifuges installed the simulator with a calibration coil springs, which provide the possibility of motion in the ankle, knee and hip joints. The duration of the daily session is from 6 to 12 minutes, the duration of 10-12 sessions.

It is assumed that active muscle work in conjunction with gravity load leads to an increase in the number of functioning blood vessels of the microvasculature and subsequent vasodilation, which allows for redistribution of blood volume in the main vascular bed is thereby reduce blood pressure.

The disadvantage of this method is the limited influence at the macro - and microcirculation, as there is direct action on the leading hemodynamic mechanism of formation of arterial hypertension - blood pressure; as well as the need to meet patients significant physical work to achieve a therapeutic effect.

Closest to the claimed invention by the technical result is a method of normalizing blood pressure neuroinformation acoustic signals (Showa H. A. Action neuroanesthesia signals on the physiological functions of the human body. Abstract. Diss., Maykop, 2011, S. 7-19).

The method includes remote effects on the human body neuroinformation acoustic signals, copied from a pulsed electrical activity of neurons in the cerebral cortex of experimental animals, after preliminary adapting animals to hypoxia in a pulsed mode of its origin, and subsequent modeling of the electrical signals of the neuron, transfer them to the media.

Study of the influence of the models of functioning of a neuron adapted to pulse hypoxia, was carried out on healthy people aged 19-23 years. The exposure was carried out for 10 days in 5 minutes a day n stochasticity rhythmic acoustic signals (up to 10 Hz), then within 10 days after 5 minutes a day of high-frequency arrhythmic acoustic signals (above 10 Hz), which reproduces the pulse parameters of electric activity of neurons adapted to pulse hypoxia. Investigated the dynamics of the minute volume of respiration (MOD) and the change in the concentration of carbon dioxide (CO2) in arterial blood.

It is established that under the influence of the tested models is a reduction in minute volume of respiration and physiological increase in the level of carbon dioxide in arterial blood, which leads to the removal of spasm of the vessels observed before stimulation electroacoustic arrhythmic signals. It increased adaptive and compensatory capacity of the organism.

The method has the following disadvantages:

1) there is no information about the normalization of AD patients with hypertension using this method, since the studies were carried out on healthy people aged 19-23 years, having a very narrow range of deviations of parameters from the norm (for example, total peripheral resistance vessels in normal physiological conditions is from 1200 to 1600 Dyne·s·cm-5and with hypertension this value may increase and range from 2200 to 3000 Dyne·s·cm-5; pulse pressure normal costs the t 40-45 mm RT.art., as with hypertension, this value can reach 50-70 mm RT.V.);

2) the complexity of the practical implementation of the method for medicinal purposes, as it does not specify a specific value of the stimulation modes arrhythmic signals depending on the stage of the disease (specified low-frequency signals up to 10 Hz and the high frequency is more than 10 Hz);

3) duration of study, providing for two stages in two different sessions: low-frequency (10 days) and high frequency (10 days):

The claimed invention solves the problem of extending the practical application of the method of remote influence on the human body for the treatment of cardiovascular diseases, as well as shorten the duration of treatment.

The method includes a preliminary measurement of systolic and diastolic blood pressure (BP) in the morning, on an empty stomach, consistently on the left and right hands of the patient, the calculation of the average systolic and average diastolic blood pressure according to the standard technique, and then conducting a remote session acoustic signals using the laser generator, the measurement after the end of the session, systolic and diastolic blood pressure consistently on the left and right hands of the patient, the calculation of mean values of systolic and diastolic blood pressure and a comparison showing the indices of arterial pressure, the resulting session, with the original indicators. The assessment results to assign the number of sessions of exposure is conducted according to the deviations of the obtained average values of arterial blood pressure from normal values.

The invention consists in that register pulsed electrical activity of neurons with sensorimotor cortex of experimental animals adapted to hypoxia, modeling frequency activity of the multivibrator and electroacoustic Converter, copy signals, transfer them to the media, and remote influence on the patient using the laser generator, and remote influence of acoustic signals is carried out sequentially: first sessions are conducted with a frequency of 5-8 Hz for 5-7 minutes, then the session with a frequency of 10-15 Hz for 5-8 minutes, every day, one session per day rate 10-14 sessions.

Integral indicator of the impact of acoustic signals is the decrease in blood pressure.

The technical result of the invention is the ability to normalize blood pressure in remote acoustic signals that affect the macro - and microcirculation of the body.

The reduction in the duration of treatment is ostiguy by reducing the number of sessions: one session per day, course 10-14 sessions.

We established that under the influence of infrasound signals is a decrease in the amplitude of the alpha rhythm in the electroencephalogram. Therefore, low-frequency acoustic signals can have a sedative effect on the cerebral cortex, thereby helping to reduce the voltage of the nervous system, including through the VASO-motor centre. Acoustic signals of frequency from 5 to 20 Hertz, acting on the nervous system, cause the tonus of the vagus nerve (n. vagus), which reduces vascular tone, causing bradycardia - decreased heart rate, decrease heart rate, which leads to lower blood pressure.

Received advice on modes of acoustic signals depending on the stage of the disease. The purpose of the impact - normalization of the blood pressure to a level: 120-135/80-90 mm RT.article.

The results are shown in table 1.

For carrying out the proposed method of electroacoustic signals (pulsed electrical activity and accompanying sound signals) were recorded in the sensorimotor areas of the cerebral cortex of experimental animals (rats "Wistar"), adapted to the interval rhythm (pulse) hypoxia, using microelectrode on the depth 750-850 μm, which was judged according to the testimony mi is remanipulate stereotaksicescuu installation. Pulsed electrical activity depends on the functional state of the neuron.

Record electroacoustic pulse signals of electrical activity in nerve cells of the cerebral cortex of experimental animals was carried out using a comprehensive electrophysiological microelectrode techniques, including: platinum microelectrode 2 microns in diameter, stereotactic cathode follower, the biopotential amplifier, the Registrar of bioelectric activity (show MT, Kurdanov H. A., Shikova O. C. Oxybiotic, electrophysiological and energetic adaptation mechanisms of nerve cells to hypoxia. Voronezh: "Scientific book", 2010. - S. 44-50).

Sound pulses derived from the electrical discharges of the plasma membrane of neurons, listened with connected to microelectrode receiver, which was part of electrophysiological techniques.

The main carrier of information is the frequency of the acoustic pulses that operate in the low-frequency mode, which is modeled using radio equipment, including pulse multivibrator and electro-acoustic transducer. Frequency acoustic pulses coincide with the frequency of the electrical discharges of nerve cells.

Transcript of audio recording of impulse the th electrical activity to determine the frequency of the pulses was performed using a radio installation consisting of a pulse of the multivibrator and electro-acoustic transducer, thus made a physical model of the established frequency acoustic signals of nerve cells. Then made up electro-acoustic signals in a digital format and then transfer the simulated electrical signals from neuron to storage media (flash card). As a generator of acoustic signals used laser system - micro system MMK - 625 U (manufacturer Mystery electronics co., Ltd.), which consists of an electronic control unit and two speakers; media serves as a flash card. The generator was located at a distance of 2-2,5 meters from the subject patient. The impact indicator signals was the change in blood pressure.

The study of the mechanisms of adaptation of nerve cells to pulsed hypoxia indicates that the electrical activity of nerve cells often reaches a stable level with the dominance of two modes: continuous rhythmic succession of pulses of low frequency (less than 10 pulses per second) and discharges electric pulses of a higher frequency (more than 10 pulses per second).

Nerve cells generate low-frequency pulsed electrical discharges in terms normoxia formed the OJ under the influence of sessions of intermittent hypoxia. Electric pulses of higher frequency neurons generate under the influence of acute hypoxia in the formation process of adaptation and adaptation in a sharp decline in oxygen tension below normal. Information in pulsed electrical activity of a neuron controls the oxygen regime in the cell, maintaining it in a state of normoxia and protecting vital organs from hypoxia, which is the main cause of hypertension (show MT, Kurdanov H. A., Shikova O. C. Oxybiotic, electrophysiological and energetic adaptation mechanisms of nerve cells to hypoxia. Voronezh: "Scientific book", 2010. - S. 95-104).

Statistical processing were subjected to the observation of 50 patients aged 19 to 65 years with arterial hypertension (AH) 1-2 degrees. The diagnosis of hypertension was verified modern methods of examination including echocardiography, daily monitoring of ECG and blood pressure, study of the level of hormones, the study of the fundus. Was conducted computer or magnetic resonance tomography. Before the beginning of the treatment session in the morning from 8 to 9 hours on an empty stomach, and after the end of the session, all patients were measured sequentially on the left and right hands, indices of systolic and diastolic blood pressure. Precision measurement is possible HELL ±2 mm RT.article Expected average systolic blood pressure and mean diastolic blood pressure before and after the session. The indicators of the survey were processed using the computer program Statistica (USA). Dynamics of changes in blood pressure (mean values) are presented in table 2.

Under the influence of the acoustic signal generator is a decrease and stabilization of indices of systolic and diastolic BP, mean BP was maintained during the action.

Examples of specific performance

Example 1. Examined the patient S., aged 28 years, the diagnosis of arterial hypertension of the 1st degree. Complaints about persistent headaches. The measured parameters of blood pressure fasting: on the left hand: 142/93 mm RT.article; on the right hand: 139/87 mm RT.art., average AD: to 140.5/90 mm RT.article.

Conducted 10 sessions acoustic signals: 5 sessions with a frequency of 5 Hz for 5 minutes and 5 sessions a frequency of 10 Hz for 6 minutes. The sessions were held 1 time per day, indoors in a quiet, steady breathing, comfortable condition of the patient located at a distance of 2 m from the signal generator.

Indicators HELL after the first session: on the left hand: 132/87 mm RT.article; on the right hand 130/85 mm RT.article; mean BP: 131/86 mm RT.article.

Indicators HELL after 10 sessions: on the left hand: 123/85 mm RT.article; on the right hand 125/85 mm RT.art., mean BP: 124/85 mm RT.art./p>

Decreased intensity of headaches, no dizziness.

Control examination after 6 months: mean HELL 125/78 mm RT.article.

The values of blood flow within normal limits.

Example 2. Examined the patient K., aged 47 years, the diagnosis of arterial hypertension of the 1st degree. Complaints about persistent headaches, dry mouth, lethargy. Excess body weight 27 kg

Parameters HELL on an empty stomach: on the left hand: 153/98 mm RT.article; on the right hand: 157/97 mm RT.article; mean BP: 155/97,5 mm RT.article.

Conducted 12 sessions acoustic signals: 6 sessions a frequency of 7 Hz for 7 minutes and 6 sessions frequency of 12 Hz for 6 minutes. The sessions were conducted 1 time a day and took place in a closed room with a quiet, steady breathing, comfortable condition of the patient located at a distance of 2.2 m from the signal generator.

Indicators HELL after the first session: on the left hand: 138/88 mm RT.article; on the right hand 136/85 mm RT.article; mean BP: 137/86,5 mm RT.article.

The parameters of blood pressure after 12 sessions: on the left hand: 128/84 mm RT.article; on the right hand 126/85 mm RT.article; mean BP: 127/84,5 mm RT.article.

Decreased intensity of headaches, increased activity.

Control examination after 6 months: mean HELL 128/82 mm RT.article.

The values of blood flow within normal limits.

Example 3. Examined the patient R. aged 56 years, the diagnosis: hypertension 2, article is fine. Complaints flooded headaches, weakness. Sick 6 years. Parameters HELL on an empty stomach: on the left hand 165/108 mm RT.article; on the right hand 167/100 mm RT.article; mean BP: 166/104 mm RT.article.

Held 14 sessions acoustic signals: 7 sessions frequency of 8 Hz for 7 minutes and 7 sessions with a frequency of 15 Hz for 8 minutes. The sessions were held 1 time per day, indoors, during quiet breathing of the patient located at a distance of 2.5 m from the signal generator.

Indicators HELL after the first session: on the left hand: 140/92 mm RT.article; on the right hand 144/90 mm RT.art., mean BP: 142/91 mm RT.article.

Indicators HELL after 14 sessions: on the left hand: 130/86 mm RT.article; on the right hand 132/87 mm RT.article; mean BP: 131/86,5 mm RT.article.

Decreased intensity of headaches, no dizziness, increased activity and performance. Control examination after 6 months: mean BP 130/80 mm RT.article The values of blood flow in normal, hypertensive crises were not observed.

The advantages of the proposed method in comparison with the prototype is the ability to normalize blood pressure in violations and the risk of hypertension. The method does not cause overstimulation of the Central nervous system, has no harmful side effects, the most simple, safe, available for use at any time, in any place, for the Aulnay of any age. The method is suitable for the prevention of heart attacks, strokes, coronary heart disease.

The way to normalization of blood pressure, including registration pulsed electrical activity of neurons with sensorimotor cortex of experimental animals adapted to hypoxia, modeling frequency activity of the multivibrator and electroacoustic Converter, copy signals, transfer them to the media, and remote influence on the patient using a laser generator, wherein the remote influence of acoustic signals is carried out sequentially: first sessions are conducted with a frequency of 5-8 Hz for 5-7 minutes, then the session with a frequency of 10-15 Hz for 5-8 minutes, every day, one session per day rate 10-14 sessions.



 

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FIELD: medicine.

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3 dwg, 4 tbl, 2 ex

FIELD: medicine.

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4 ex, 2 tbl

FIELD: medicine.

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FIELD: medicine.

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13 cl, 4 tbl, 4 dwg

FIELD: medicine.

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1 ex

FIELD: medicine; physiology and therapy.

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6 dwg

FIELD: medicine, neuroophthalmology.

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2 ex

FIELD: medical engineering.

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2 cl, 6 dwg

FIELD: medicine.

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FIELD: medicine.

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1 dwg, 2 ex

FIELD: medicine.

SUBSTANCE: recent comatose condition is detected; magnetic resonance imaging shows centres of cerebral structural changes; electroencephalography shows epileptiform activity, diffuse sharp waves, spikes, reduced complexes, high-amplitude low activity paroxysmal events, frequent paroxysmal events of 'peak-slow wave' and 'spike-slow wave' complexes. The EEG also shows irritant activity, local transient high-frequency beta-activity, advanced transient low-amplitude and advance continuous long-term high-amplitude activity. The presence of an aetiological agent of the disease caused by tick-borne encephalitis or the presence of encephalitis of other and uncertain aetiology is stated. The derived data are scored depending on the presence, absence and manifestations thereof. The derived data are used to calculate linear classification functions and to detect the favourable (LCF1) outcome of encephalitis without symptomatic epilepsy (SE) progression and the unfavourable (LCF2) outcome of encephalitis with SE progression. If LCF1>LCF2, the encephalitis outcome without SE progression is predicted, while LCF2>LCF1 shows the unfavourable outcome with SE progression.

EFFECT: method provides more reliable assessment of the SE progression in encephalitis that is ensured by taking into account additional EEG data and calculating the linear classification functions.

2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to neonatology and neurology. During a 300-second slow sleep recording, transitory patterns are recovered on the EEG: frontal sharp waves of an average duration of 0.13 seconds, spike acute waves of an average duration of 0.045 seconds, high-amplitude PTӨ-waves of an average duration of 0.1 seconds, STOP-wave patterns of an average duration of 0.1 seconds. Indices (K) are calculated for each pattern in percentage, as a relation of the number of patterns of 300 seconds multiplied by its average duration to the recording duration (300 seconds). If K of the most patterns determined is less than 1, a physiologic norm is diagnosed; K falling within the range of 1-2 shows a moderate neurophysiologic immaturity; and if K is more than 2, major disturbances of the electrobiologic brain activity are stated.

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4 dwg, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to psychiatrics. In addition to the clinical study, an electroencephalography coherence analysis is conducted within the range of 30-45 Hz before psychotropic agents are prescribed. That is followed by determining middle zonal indices of the left and right hemispheres calculated between the midtemporal and following cortical regions: frontal, central, parietal, occipital, anteriofrontal and posteriofrontal in the homolateral direction. A hemispheric asymmetry factor (HAF) is calculated by dividing the middle zonal index of the left hemisphere by the middle zonal index of the right hemisphere. If the HAF value is less than 1, paranoid schizophrenia is diagnosed; and the value more than 1 shows schizo-affective disorder.

EFFECT: technique enables providing the more reliable differential diagnostics that is ensured by determining the zonal indices of the right and left hemispheres to calculate the hemispheric asymmetry factor.

2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to psychiatrics. A clinical examination is combined with recording an electroencephalogram (EEG); its spectral and coherent analyses are carried out. The following values are determined: T6-AA-lead power spectrum within the range of 3.5-5 Hz, F7-AA-lead power spectrum within the range of 2-3 Hz, T5-AA -lead power spectrum within the range of 23-24.5 Hz, hemispheric power asymmetry between F8-AA and F7-AA-leads within the range of 24.5-26 Hz, P4-C4-lead coherence within the range of 8-13 Hz, T4-F8 within the range of 23-24.5 Hz, T3-F7-lead power spectrum within the range of 26-27.5 Hz, T5-O1 within the range of 17-18.5 Hz, T3-F8 within the range of 20-21.5 Hz. Logarithms of the derived values are calculated. An integral diagnostic value is determined by mathematical formula taking into account the calculated logarithm and coefficient-corrective values. If the integral diagnostic value appears to be positive, a recurrent depressive disorder is diagnosed, while a bipolar affective disorder is shown by the negative integral diagnostic value.

EFFECT: method enables providing higher diagnostic reliability at the early stages of the disease that is ensured by the optimum selection of the values, and the mathematical calculation of the integral value.

2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, labour safety, vocational selection of rescue workers. The invention can be used for vocational selection in the sectors of industry using personal protective equipment, as well as for the workers labour safety in the sectors of industry with harmful working conditions. The method involves vocational selection and duty control on the basis of electroencephalogram (EEG) values and cardiological findings. The examination is performed prior to and when using the personal protective equipment. The cardiological examination involves assessing the heart rate variability with using the amplitude-frequency spectrum Fourier analysis VLF at a vibration frequency within the range of 0.0033-0.04 Hz, LF - at a frequency of 0.05-0.15 Hz and HF - at a frequency of 0.16-0.80 Hz, and is five-staged: initial resting state, mental work load, recovery of mental work load, hyperventilation load, recovery of hyperventilation load. At the beginning, the heart rate variations and EEG are examined prior to using the personal protective equipment. If any of the five stages of the heart rate variation examination shows the pulse more than 90 beats per minute, as well as changes from the normal values of: approximating entropy - less than 180, LF - less than 6 point, an alpha wave amplitude - to 12 vibrations per second and the presence of the paroxysmal activity by EEG, the prevailing sympathetic nervous system is stated, or if any stage of the heart rate variation examination shows the pulse less than 60 beats per minute, as well as changes from the normal values of: blood pressure - more than 140/90 mmHg, VLF - more than 130 points, HF - more than 16 points, an alpha wave amplitude - less than 25 mcV, the prevailing parasympathetic nervous system is stated; a low level of adaptation to the personal protective equipment is predicted, and a rescue work is not recommended during the vocational selection; the examination is terminated. If the heart rate variation and EEG prior to using the personal protective equipment fall within the normal values, the heart rate variation when using the personal protective equipment is started with the patient examined when using the personal protective equipment and performing a cycle ergometer test, and recording the hyperadaptotic changes of the assessed values: VLF - more than 130 points in relation to the normal value when using the personal protective equipment and LF and HF vibrations; an incomplete or unfinished adaptation to the personal protective equipment, and the rescue worker is suspended from work for several hours; if VLF is more than 130 points recorded 10-15 min after activating the personal protective equipment, a good adaptation level to the personal protective equipment is predicted.

EFFECT: method enables assessing the vegetative nervous function and predicting the rescue workers' adaptation level to the personal protective equipment.

11 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: patient is trained by challenging to imagine a paretic limb movement and controlling the imagined movement. An electroencephalography is recorded; the recorded data are transferred to a computer for synchronous processing, and arousal reaction signals of a sensorimotor rate responsible for the imagined movement are isolated by means of an EEG pattern classifier according to the Bayes method. Identification results of the mental challenge are presented to the patient by a visual feedback in the form of a mark on a monitor. The mark re-position testifies to accuracy of the challenge. The imagined movement challenge is presented for 10 seconds. The training course makes 6-12 days, one training a day, of the length of 20-30 minutes every 1 to 4 days.

EFFECT: method provides more effective rehabilitation that is ensured by the feedback training in the conditions enabling the patient controlling the imagined paretic limb movement visually.

3 dwg, 4 tbl, 2 ex

FIELD: physics.

SUBSTANCE: method includes rendering an image which creates a depth and volume effect (IDE); detecting electrical activity (EEG) of the brain for white sheet (IWS) rendering and for image IDE rendering; calculating the sum of the overall coherence amplitude on all derivations and components of EEG rhythms, first for IWS rendering (Σ(CHАIWS)), and then for image IDE rendering (Σ(CHАIDE)). If the value Σ(CHАIDE) is greater than Σ(CHАIWS) by 1.8 times or more, the capability for three-dimensional sensing of flat images is determined.

EFFECT: method enables to obtain an objective evaluation of the capability for three-dimensional sensing of flat images, which is achieved owing to use of coherent EEG analysis.

2 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, and may be used in occupational pathology. Person's open eyes are exposed to a white light of a colour temperature varying within the range of 1700 K - 10000 K. An electroencephalogram is recorded; its spectral analysis is performed to state the effect to be activating as shown by a power spectrum of alpha and theta waves reducing by more than 25% of background values.

EFFECT: method enables an individual selection of a colour temperature having the activating effect.

2 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine and may be used for assessing the light exposure generated by a light-emitting-diode source on the functional status of human brain cortex. The white light exposure covers individual's open eyes at colour temperature 1700-10000 °K, illumination 80-300 lx at the eye level. That is followed by electroencephalogram recording and spectral analysis. If observing an increase or a decrease of alpha or teta wave spectral power by more than 25% of a baseline value, the light exposure is considered to be physiologically active, and by less than 25% - as physiologically neutral.

EFFECT: method provides more reliable assessment of the functional status of human brain that is ensured by biological activity rating within the alpha and teta wave range.

4 tbl, 4 ex

FIELD: medicine, neurology, psychopathology, neurosurgery, neurophysiology, experimental neurobiology.

SUBSTANCE: one should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another.

EFFECT: higher accuracy of diagnostics.

5 dwg, 1 ex, 1 tbl

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