Pharmaceutical composition uberit for treatment of mastitis in cows based on n-tetradecyltributylphosphonium bromide
FIELD: veterinary medicine.
SUBSTANCE: pharmaceutical composition in the form of ointments for treatment of mastitis in cows comprises n-tetradecyltributylphosphonium bromide as active ingredient and petrolatum as an excipient at the ratio of 1:2000.
EFFECT: invention provides a pharmaceutical composition in the form of an ointment, which is new in mechanism of action, effective when applied topically at low therapeutic concentration.
The invention relates primarily to veterinary medicine and pharmacy, and in particular to means for the treatment of mastitis, which can be used as pharmaceuticals.
Improving the efficiency of treatment of mastitis in cows is a task that is important for ensuring high productivity of dairy cows and milk quality (Vasiliev, Century, Century, the Economic damage from the milk during mastitis in cows. // Veterinary medicine. - 2008. No. 1. - S. 32-34).
For the treatment of mastitis cows offered the use of antimicrobial drugs that are injected vnutrivenno (Sirenko, S. C. Treatment of cows with mastitis. / Sirenko, S. C., Safronov, S. L. // Agrarian Bulletin of the Urals. - 2006. No. 1. - S. 55-56).
There is a method of treatment of mastitis in cows medicinal drug Dipomat, containing in its composition dioxidine (2%), furatsilin (0,04%), beeswax and vaseline oil. In appearance it is a buttery yellow suspension which is produced in bottles of neutral glass 100 ml (20 doses) and the syringes 10 ml (2 doses). Enter intracisternal: if subclinical, serous, catarrhal mastitis in 5 ml of 1 times a day for 3-4 days; if purulent-catarrhal - first injection of 10 ml, then 5 ml with an interval of 24 hours for 5-6 days. Before the introduction of the drug from sick quarters of the udder secret vydavat and teats are disinfected with 70% atelevision. Preparation before applying heat to 36-39°C and shaken, then suck from the bottle with a sterile syringe and injected into the nipple of the affected quarter of the udder by means of a catheter (http://www.veterinar.ru/pharmacy/52/11/). The disadvantage of this method are: high cost, high concentrations of drugs in the drug, the need for special devices for administration of (syringes and dairy catheters), pre-treatment of the nipple ethyl alcohol, and the complexity vnutrivennogo (intracisternal) introduction, which is carried out by expert veterinarians.
There is a method of treatment of mastitis in cows (patent RU 2230571 published 20.06.2004). The method includes vnutriserdechne introduction staphylococcal and streptococcal anatoxins in a mixture with 25% solution of aspirin, at a dose of, respectively, 2 ml and 4 ml Method is highly effective in the treatment of mastitis coccal etiology of cows. The disadvantage of this method is the narrow spectrum of antimicrobial activity (only in respect of coccoid bacteria), while the cause of mastitis are not only streptococci and staphylococci, but also bacteria, coliform bacilli, found Corynebacterium, Mycoplasma, fungi of the genus Candida, Nocardia and others, as well as activators of specific infections (Guidance on the diagnosis, therapy and prevention of mastitis in cows. Min is Alhazred Russia, The Department of veterinary medicine, No. 13-5-2/1948, 30.03.2000, http://www.cap.ru/home/65/aris/bd/vetzac/document/371.html), and expensive due to the high content of dipyrone in pharmaceutical drug and complexity of introducing requiring special devices and participation veterinary specialists.
Closest to the claimed (prototype) is a drug for the treatment of mastitis in animals (patent RU 2200546 published 20.03.2003). The drug is in the form of ointment contains components in the following ratio, wt.%: colloid 1,5-2,0, salicylic acid 1.0 to 1.5, trimekain 0,45-0,55, Hemofarm or levamisole 0,03-0,5, carbon dioxide extract of chamomile 2.0 to 2.5, the juice of celandine 1,5-2,0, dimexide 29,0-33,0, anhydrous lanolin 46,9-47,65 distilled water - the rest. The drug improves the efficiency of treatment. The disadvantage of this drug are mnogonapravlennostj increasing as the cost of the drug, the risk of adverse reactions. So, when using levamisole may cause excitation, increased salivation, increased defecation and urination, ataxia (http://www.vetlek.ru/directions/?id=223). Lanolin may have allergenic and sensitizing effects (Technology of medicinal forms: a Textbook in 2 volumes. Volume 1 / T. S. Kondratyev, L. A. Ivanov, Y. I. Zelikson and others/ edited by T. S. Kondratieva. - M.: Medicine, 1991. - S. 285). When mixed with salts of heavy is yellow (in this example - silver contained in the product "colloid") lanolin its shades, and formed metallic Soaps increase the toxicity of ointments (Reference pharmacist. / Ed. by A. I. Tenzaloy. - M.: Medicine, 1981. - S. 14).
Thus, used drugs have one or more negative properties: high cost, complexity intracisternal introduction did, the activity in relation to a limited range of microorganisms, toxicity. Therefore, the creation of new efficient and easy to use domestic products for the treatment of mastitis in cows is important.
Objective of the claimed technical solution is the creation of effective drug for the treatment of mastitis in cows based on phosphonium salts of simultaneous antibacterial and antimycotic treatment steps, with high penetration and, consequently, low therapeutic doses.
Quaternary phosphonium salts of belong to the III and IV toxicity class - "moderately hazardous" and "toxic" substances, and possess high antibacterial and antimycotic activity against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis and Candida Albicans [Galkin I. C. Synthesis, structure and study of biological activity of phosphonium salts. / I. Galkina, Turi E. C., Bakhtiyarova Y. C., S. Egorova N., Galkin Century. And.// In the b.: Pharmacology and toxicology of organophosphorus compounds and other biologically active substances. Issue 4: proceedings of the Russian conference dedicated to the 75th anniversary of Professor I. A. Studentswas. - Kazan, 2008. - S. 23]. High antimicrobial, antifungal and antiparasitic activity of salts of Quaternary phosphonium determine the prospects of their application in medicinal forms of local action for treatment of mastitis in cows, in particular n-hexadecyltrimethylammonium bromide with LD502500 mg/kg
The technical result of the claimed invention is the creation of a new mechanism of action of the pharmaceutical composition effective for the treatment of mastitis in cows in the local application in the form of ointment at low (0.05%) of therapeutic concentration.
The claimed technical result is achieved by the use of a composition containing n-tetradecyltrimethylammonium bromide as the active component and the vaseline (excipient) at a ratio of 1:2000.
It is important that the salt of Quaternary phosphonium, in particular, n-tetradecyltrimethylammonium bromide, are stable amphiphilic detergents, interphase catalysts, working both in aqueous and fatty phase and, as a consequence, penetrating agents through biomembranes. As we have shown, Quaternary phosphonium salts of possess high antibacterial properties due to the interaction with the lipid to what components of cell membranes [Galkin, I. C., Melnikova N. B. Turi E. C., Galkin Century. And., Zhiltsov O. E., Zhukova O. C., S. Egorova N. The interaction of phosphonium salts with the lipid components of membranes. / Pharmacy, 2009 - No. 4. - S. 35-38].
Of the investigated prior art is not revealed information about the use of salts of Quaternary phosphonium for the treatment of mastitis in cows, which is proof of the compliance of the claimed technical solution to the criterion "novelty" requirements for inventions.
The active ingredient of the inventive compositions based on salts of Quaternary phosphonium n-tetradecyltrimethylammonium bromide and excipient vaseline in the ratio of 1:2000 used in the claimed technical solution for new purpose - as a drug for the treatment of mastitis in cows, which is obviously not obvious to a person skilled in the analyzed field of technology, thus, the claimed technical solution meets the criterion of "inventive step" requirements for inventions.
The claimed technical solution meets the criterion of "industrial applicability", presented to the invention, since the claimed composition can be obtained by using known components using standard equipment and known methods of pharmaceutical technology.
The essence of the claimed technical the definition of the solution is the creation of a pharmaceutical composition, containing n-tetradecyltrimethylammonium bromide as the active component and petrolatum at a ratio of 1:2000.
The claimed technical solution is as follows:
1. Receive the first component of the claimed composition halide salt of Quaternary phosphonium n-tetradecyltrimethylammonium bromide of General formula (I) by the method described in [Stark H. M. interfacial catalysis. Chemistry, catalysts and application. / Ed. H. M. Starks. M.: Chemistry, 1991. - 157 C.]:
where R1=C4H9C6H5; R2=C12H25With14H29With16H33; Hal=Br
2. Receive pharmaceutical composition through preparation of an ointment composition of 1:2000 of the component of formula I and vaseline.
Advantages of the proposed pharmaceutical composition in the form of ointments is that it is simple in manufacture, use and has therapeutic activity at low concentrations (0.05 per cent), making it a promising drug in veterinary medicine for the treatment of mastitis in cows.
The claimed technical solution is illustrated by the following examples, but is not limited to them.
Example 1. Obtaining a pharmaceutical composition for the treatment of mastitis in cows.
In a porcelain mortar weighed 1 g n-tetradecyltrimethylammonium bromide, pound and mix is with 100 g of vaseline until a homogeneous mass (concentrate). In the capacity maselesele weighed 1900 vaseline, heated to 40°C, stirred and gradually, in small portions when the stirrer type of mortar concentrate. The ointment is stirred for 20 minutes and Packed in glass jars.
Example 2. To study the efficacy of the pharmaceutical compositions of n-tetradecyltrimethylammonium bromide and vaseline (1:2000) for the treatment of mastitis in cows.
Test the effectiveness of the pharmaceutical compositions of n-tetradecyltrimethylammonium bromide and vaseline (1:2000) was performed in the treatment of catarrhal form of mastitis in 5 cows.
Ointment rubbed into the udder 2 times a day, after milking for 5 minutes, combined with massage of the udder.
The results of the study:
Day one: Udder inflamed, red, swollen nipple, painful, touching him cow kick, do not admit to themselves. Milk vydelaetsia with great difficulty. They received milk depending on the type of mastitis watery; contains flakes, or blood clots. Conducted test Trinity mastitis test revealed the presence of mastitis (by the presence of flakes and mucus in the sample of milk in connection with the reagent).
Day two: the Udder is still inflamed, red, swollen nipple, pain in durgiana. Milk vydelaetsia with difficulty, the first stream containing a small amount of flakes.
Day three Udder normal size, the redness is almost absent, nipple less swollen, the pain is negligible. The animal let to itself. Milk vydelaetsia with some difficulty, milk contains a small amount of flakes. Test with Trinity mastitis test shows the presence of mastitis; milk sample still slimy.
Day four: Udder normal size, painless, nipple normal size, blood is missing. Milk vydelaetsia easily and freely. They received milk from the affected quarter is no different from milk from healthy quarters. Test with Trinity mastitis test shows the presence of mastitis; milk sample contains a small amount of mucus.
Day five: Udder normal size, painless, local temperature is not increased, the nipple is normal in size. Milk vydelaetsia easily, they received milk, appearance and texture is no different from milk from healthy quarters. Conducted a test with Trinity mastitis test - mastitis test is negative.
Outcome: full clinical recovery. Consumption of pharmaceutical compositions of n-tetradecyltrimethylammonium bromide and vaseline (1:2000)100 g ointment in the treatment of 1 cow.
Pharmaceutical composition for treatment of mastitis in cows, containingn-tetradecyltrimethylammonium bromide as the active component and vaseline as an excipient in a ratio of 1:2000.
SUBSTANCE: invention relates to novel hexasubstituted para-aminophenols: where R=C6H5, C6H4Cl, C6H4Br, C6H4CH3, with arylamide groups in 2,6 positions with respect to hydroxyl, which demonstrate antibacterial activity.
EFFECT: hexasubstituted para-aminophenols with arylamide groups in 2,6 positions with respect to hydroxyl, possessing high bactericidal and bacteriostatic activity.
1 tbl, 4 ex
SUBSTANCE: invention relates to veterinary, in particular to obstetrics, gynecology and reproduction biotechnology, and can be used for treating animals in case of clinical mastitis. Medication for treating animals with clinical mastitis includes: trivit - 10.0 ml, cefotaximum - 750 mg, prednisolone - 10.0 mg, nystatin - 325.0 ml. Medication is introduced to ill animals intracycternally in dose 10.0 ml with interval 12 hours after milking.
EFFECT: invention provides increased efficiency of treating clinical mastitis by complex impact on all sides of pathological process.
4 tbl, 3 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, more specifically to new dosage forms of cephem compounds effective for treating bacterial infections.
EFFECT: dosage forms are stable; they show the improved solubility and are especially applicable for parenteral administration.
9 cl, 29 tbl, 8 ex
SUBSTANCE: invention relates to field of veterinary and is intended for treatment and prevention of postpartum acute mastitis in cows. Medication contains antimicrobial, anti-inflammatory preparations and distilled water. Medication additionally contains licorice root. As antimicrobial preparation it contains metronidazole. as anti-inflammatory preparation it contains ciprofloxacin, with the following component ratio, g/l: licorice root 80-85 g; metronidazole 3.5-4.0 g; ciprofloxacin 2.0-2.5 g; distilled water - the remaining part.
EFFECT: application of claimed medication provides expressed antimicrobial and anti-inflammatory effect with simultaneous reduction of organism's response to histamine, release of spasm of smooth muscles and reduction of permeability of capillaries.
4 tbl, 10 ex
SUBSTANCE: method involves prescribing proton pump inhibitor with one antibiotic in a dual therapy and with two antibiotics with a triple therapy twice a day within the course of 7-10 days. Helicobacter is eradicated by the separate administration of drugs. The proton pump inhibitor (omeprazole or pantoprazole) is administered two hours before the antibiotic in the dual therapy and four hours before the second antibiotic in the triple therapy. The drugs are taken for the second time 12 hours after the first one. The antibiotics (clarithromycin, amoxicillin or fromilid) are taken with water 250ml.
EFFECT: invention enables providing the more effective eradication of Helicobacter by the exposure of total therapeutic bioavailability of each preparation with underlying permanent gastric alkaline environment.
2 cl, 3 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to the pharmaceutical industry and represents a cream for medical application for local treatment of bacterial infections and for wound healing, which contains fusidic acid in an amount of 0.1 wt % to 25 wt % and a biopolymer, preferentially chitosan; fusidic acid is formed in situ in an oxygen-free medium; the above cream contains fusidic acid formed in situ by transforming sodium fusidate at adding the acid slowly, with a particle size of an active agent of the substance of 2.33 mcm to 16.3 mcm, while the biopolymer is introduced into a cream base containing at least one ingredient of each type: primary and secondary emulsifying agents specified in a group containing ketostearyl alcohol, ketomacrogol-1000, polysorbate-80, Span-80, paraffin as a wax product, a combined solvent specified in a group containing propylene glycol, hexylene glycol, polyethylene glycol-400, nitric acid or lactic acid and water.
EFFECT: invention provides the high stability of the active ingredient during the whole shelf life.
12 cl, 18 tbl, 2 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biotechnology and represents a composition for inducing an immune response against Staphylococcus aureus (versions), a method for inducing the immune response against Staphylococcus aureus, and a method for eliciting passive immunity against Staphylococcus aureus in an individual. The composition contains an effective amount of the recovered capsular polysaccharide 5 S. aureus conjugated with the CRM197 carrier protein, an effective amount of the recovered capsular polysaccharide 8 S. aureus conjugated with the CRM197 carrier protein, and at least one ingredient specified in a group consisting of an effective amount of the recovered polypeptide of the clumping factor A (ClfA) of S. aureus, an effective amount of the recovered polypeptide of the clumping factor B (ClfB) of S. aureus (ClfB) and an effective amount of the recovered protein MntC of S. aureus. The capsular polysaccharide type 5 represents a capsular polysaccharide of high molecular weight from 70 to 300 kD. The capsular polysaccharide type 8 represents a capsular polysaccharide of high molecular weight from 70 to 300 kD, wherein from 5 to 23 lysines in CRM197 are conjugated. The CP5 and CP8 conjugates have the molecular weight from approximately 200 kD to approximately 5000 kD.
EFFECT: presented invention enables eliciting the improved immune response against Staphylococcus aureus.
25 cl, 29 dwg, 26 tbl, 32 ex
SUBSTANCE: method involves immunising with 5×107 microbial cells Vibrio cholerae 5879; 10 days later, a common pool of anticholeraic Ig is recovered from enteric washing liquid. That is combined with producing the primary enterocyte culture from intact mice. Thereafter, the doubly-diluted anticholeraic Ig are applied in an amount of 3 ml on a monolayer of erythrocytes formed in wells of culture panels. The latter are added with alive choleraic vibrions of the strain Vibrio cholerae 5879, 40 m.c. per 1 erythrocyte and incubated for 3 hours. Then, the panels are washed three times, fixed with ethanol for 20 minutes and stained by Romanowsky-Giemsa. Local humoral anticholeraic immunity is assessed under the microscope by the number of vibrions stained in dark blue and attached to one erythrocyte.
EFFECT: method enables assessing specific local humoral immunity and intensifying the anti-adhesive activity of the common pool of anticholeraic immunoglobulin.
4 cl, 2 ex, 2 tbl
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to new bacitracin compounds with antibiotic activity
wherein at least one of R1, R2 and R3 represents -CH=CH2 and wherein R1, R2 and R3 independently represent -H, -CH3 or -CH=CH2.
EFFECT: preparing the new bacitracin compounds.
13 cl, 8 dwg, 7 tbl, 5 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to new compounds of formula I and their pharmaceutically acceptable salts, method for preparing them by the fermentation of a microorganism of the species Streptomyces (PM0626271/MTCC 5447), and to their pharmaceutical compositions containing one or more compounds of formula I as an active ingredient.
EFFECT: compounds of formula I are used for treating and preventing the diseases caused by bacterial infections.
4 cl, 3 dwg, 6 tbl, 9 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, and concerns a pharmaceutical composition in the form of tablets for oromucosal administration in treating infectious-inflammatory oropharyngeal diseases. The composition contains recombinant interferon specified in a group: recombinant interferon alpha, recombinant interferon beta, recombinant interferon gamma; amino acid specified in a group: arginine, histidine, glycine, glutathione, lysine, methionine, cysteine; an antiseptic, a preserving agent, flavours specified in a group: tea tree oil, eucalyptus leaf oil, mint leaf oil and a consistence base.
EFFECT: invention makes the composition applicable in fragile and frequently ill patients for reducing a disease recurrence.
7 cl, 1 ex
SUBSTANCE: pathogenetic treatment of chronic tonsillitis and/or hypertrophy of palatine tonsils in preschool children suffering from lymphoproliferative syndrome is ensured by the palatine tonsils debridement. An interleukin-1β(IL-1β) level is measured in the palatine tonsils washing. If the measured value is less than 5.8 pg/ml, recombinant interleukin-1β (IL-1β) is to be administered orally by phonophoresis with the use of the Tonsillor MM apparatus. Two courses of 10 procedures every 14 days are performed. The clinical effectiveness is assessed if observing a positive dynamics of IL-1β measured in the palatine tonsils washing 17 and 41 days after the beginning of the immunomodulatory therapy.
EFFECT: higher clinical effectiveness ensured by the differentiated selection of children for carrying out the immunomodulatory therapy, reducing a rate of infectious involvements of the palatine tonsils in the declared group of patients by the pathogenetically reasoned application of recombinant IL-1β.
3 cl, 2 tbl, 1 ex
SUBSTANCE: present invention refers to medicine. The preparation contains the active substance furacilin (nitrofural, 2-[(5-nitro-2-furanyl)methylen]hydrazine carboxamide), the excipient - sodium chloride, a gas-forming mixture, an acidity regulator for reducing pH from 6.5 to 7.5 and a lubricant if needed. The gas-forming mixture consists of an organic acid and sodium hydrocarbonate. According to the method for preparing effervescent tablets of furacilin, furacilin and sodium chloride are milled in a combination; all the ingredients are placed into a mixer, and the prepared mixture is tabletted by direct compression. The antimicrobial therapeutic preparation of furacilin in the form of effervescent tablets is used for septic wounds, bed sores, small skin damages, including scratch marks, abrasions, cuts; infectious-inflammatory oral and throat diseases, including acute tonsillitis, stomatitis, gingivitis and tonsillitis. The effervescent tablets of furacilin are storage-stable for two years and water-soluble at room temperature for 5 minutes.
EFFECT: preparing the antimicrobial therapeutic preparation in the form of the effervescent tablets used for preparing the solution for local and external application.
4 cl, 6 tbl, 3 ex
SUBSTANCE: biologically active additive Laviocard+ is prescribed orally 1 capsule 2 times a day with food for 21 days. That is combined with daily wound irrigations with neutral analyte of anhydrohexitol nucleic acid with leaving a sterile gauze bandage impregnated with neutral analyte of anhydrohexitol nucleic acid in the wound until it is clean. That is followed by daily bandaging with Lavitol cosmetic dihydroquercetin powder applied on the wound surface 1-2 mm thick until the wound is healed.
EFFECT: reduced length of wound healing by stimulating the regeneration processes in tissues.
1 ex, 3 tbl
SUBSTANCE: inorganic clay, represented by sodium-calcium, and/or calcium and/or ferrous forms of montmorillonite, is modified with a water solution of silver nitrate with a concentration 0.16-9.9 wt % in a weight ratio clay:water solution of silver nitrate 1:5. Modification is carried out with mixing from 3 to 7 hours at a temperature in the interval from 10°C to the temperature of boiling. The obtained material is washed with distilled water to pH ≈6-5, until excess of silver nitrate is removed, stood at room temperature and decanted. The material is dried at a temperature of 20-160°C.
EFFECT: obtaining an efficient antibacterial material for traditional and veterinary medicine.
2 tbl, 5 ex
FIELD: veterinary medicine.
SUBSTANCE: agent for prevention of mastitis in dairy cows in the dry period, characterised in that it contains as ingredients the polymer PVP/VA, silicone, polyhexamethylene biguanide, ethyl alcohol, glycerol - as emollient component, gelation agents - triethanolamine and carbopol and purified water in the following ratio of ingredients, %: polymer PVP/VA 9-10; silicone 5-6; ethyl alcohol 35-40; polyhexamethylene biguanide 0.008-0.01; glycerol 5; gelation agents - triethanolamine and carbopol 0.1; purified water - the rest.
EFFECT: method enables to minimise or eliminate the use of chemotherapeutic agents, antibiotics and their derivatives, sulphonamides, nitrofurans and eliminate the side effect of the agent on animal body, as well as to reduce the number of visits of the veterinarian during the dry period of cows, to improve the preventive efficacy.
1 tbl, 3 ex
SUBSTANCE: invention refers to the veterinary science, particularly to substances used in treating purulent-necrotic involvements of bovine's distal extremities, including digital dermatitis. A preparation for treating bovine digital dermatitis in the form of an ointment consists of an excipient, containing an ointment base, and an active ingredient - zinc oxide and copper sulphate in the following proportions, wt %: zinc oxide 9-11, copper sulphate 35-45, the ointment base - the rest.
EFFECT: invention provides higher clinical effectiveness with cost cutting for the ointment preparation.
SUBSTANCE: invention refers to medicine, namely to otorhinolaryngology, and may be used for the preoperative preparation of the patients suffering a perforated nasal septum. Intranasal silicone splints are placed 10 days before the operation. The splint is incised from one side within a perforation border. A 30° endoscope is used to assist a 7-day daily nasal perforation rinsing with chlorhexidine. A suction unit is used to evacuate mucosal secretion; synthomycin ointment is introduced through the incision in the silicone splint to the perforation region. The nasal cavity is irrigated daily with antiseptic and vasoconstrictive preparations. On the 7th day, the intranasal splints are removed.
EFFECT: method enables relieving the mucosal inflammation within the perforation, promotes the prolonged drug retention in the introduction place, ensures avoiding an overlay of a secondary infection, improves the functional state of ciliated epithelium.
SUBSTANCE: invention refers to medicine, namely to surgical dentistry and maxillofacial surgery, and is applicable in maxillary sinusotomy with fistula repair. A mucous membrane is incised to a bone under an intubation narcosis after a two-fold preparation of a surgical area. A D-shaped flap is cut out within an alveolar socket of an extracted tooth to be extended along a mucobuccal fold of an upper jaw on one side to a second incisor, and on the other side - to a third molar. The flap together with the periosteum is separated and retracted upwards with exposing a canine fossa and the alveolar socket of the extracted tooth. A hole is created within the canine fossa. Pathologically changed tissues or all sinus mucosa is scooped with a bone curette through the created hole. The alveolar socket of the extracted tooth is inspected. After the cavity has been scooped, an artificial hole is created towards a nasal cavity through an inferior nasal meatus. The sinus cavity is packed with a iodoform cotton swab; an end of the cotton swab is laid thoroughly on a sinus bottom, namely within the defect; the end of the cotton swab is brought out into a nose. A mucoperiosteal flap is mobilised within the alveolar socket of the extracted tooth, laid on the alveolar socket; the wound is closed completely. In the postoperative period, the cotton swab is removed from the sinus on the 9-10th day. The sutures are removed on the 10-11th day.
EFFECT: method enables reducing an incidence of recurrent oroantral communications in the postoperative period ensured by a compact packing of the sinus, and the antiseptic and regeneration effect of iodoform on the maxillary sinus.
SUBSTANCE: invention relates to veterinary science, namely to obstetrics and gynaecology. A preparation for treating and preventing sub-clinical, clinical, acute and chronic mastitis in farm and domestic animals contains an active substance that is - triphenyl-(3,5-di-tert-butyl-4-hydroxybenzyl)phosphonium bromide and a pharmaceutically acceptable carrier that is Vaseline in ratio 1:2000.
EFFECT: invention provides the higher antimicrobial effectiveness and the lower toxicity of the ointment with the lower concentration of the active substance.
3 tbl, 5 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to manufacturing pharmaceutical drugs. A drug represents a solution of N,N'-diaminodiphenylsulphone in a mixture of solvents: ethanol and water and at least one of the solvents specified in a group including propylene glycol, benzyl alcohol and glycofurol. Preferentially, the solution contains ethanol 25%, propylene glycol 58%, benzyl alcohol 1%, glycofurol 5% and water 11%.
EFFECT: what is prepared is the dosage form of N,N'-diaminodiphenylsulphone used for cerebral infarction, epilepsy, a traumatic marrow injury, a craniocerebral injury, leprosy, pneumocystis carinii infections, and any condition requiring fast and full absorption of the formulation.
13 cl, 6 dwg, 1 ex