Pharmaceutical composition for preventing and treating infectious-inflammatory diseases of various origins by oromucosal administration
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, and concerns a pharmaceutical composition in the form of tablets for oromucosal administration in treating infectious-inflammatory oropharyngeal diseases. The composition contains recombinant interferon specified in a group: recombinant interferon alpha, recombinant interferon beta, recombinant interferon gamma; amino acid specified in a group: arginine, histidine, glycine, glutathione, lysine, methionine, cysteine; an antiseptic, a preserving agent, flavours specified in a group: tea tree oil, eucalyptus leaf oil, mint leaf oil and a consistence base.
EFFECT: invention makes the composition applicable in fragile and frequently ill patients for reducing a disease recurrence.
7 cl, 1 ex
The invention relates to the field of medicine and for the prevention and treatment of infectious and inflammatory diseases of different etiology of upper respiratory tract, oral cavity and pharynx in children and adults by oromucosal the introduction of tablets.
The treatment of infectious-inflammatory diseases of the oral cavity and pharynx is a topical issue due to the wide spread of this disease in both adults and children.
The urgency of the problem determines a large assortment of drugs for local and General steps used in the treatment of these conditions (SU 1659054, EN 93041374, US 5248503).
One of the areas of search for such drugs is the creation of dosage forms for oromucosal route of administration that allows to increase the duration of the effects of medicinal substances on mucous membranes of the oropharynx due to slow dissolution in the mouth - dissolving tablets, drops, syrup. In the majority of antimicrobial agents local actions are antiseptics that may be a possible cause of adverse reactions, especially in children and patients with chronic diseases. In this regard, the widespread medicines, including herbal components (eucalyptus, mint, sage, St. John's wort, and others). Such as Sinupret, Tonsillar N, the Tone is iprit, Bronchipret (medi.ru, "Bionorica" in Ukraine "Herbal medicines for the treatment of colds"). Herbal remedies contain complexes of biologically active substances, similar to the metabolites of an organism, biologically compatible and have a normalizing influence on the modified functions of the body. These features allow virtually eliminate toxic and side effects.
The disadvantage of most common drugs of plant materials is that they have only local effect. Such treatment should be supplemented with total therapy, a large number of other anti-inflammatory drugs, antihistamines, vitamins and other
Infectious-inflammatory diseases, along with local antimicrobial and anti-inflammatory action, there is a need to restore homeostasis and mobilization adaptogenic abilities of the body and its immune responses. This purpose can be used multicomponent drugs, providing a comprehensive therapeutic effect.
In addition, there is a problem of reducing recurrence of the disease, since, as a rule, with the weakening of nonspecific resistance of the organism, as well as local immunity celebrated the re-development of acute respiratory infections, stomatitis, pharyngitis, tonsillitis, etc.,
Us our tasks is not only the treatment of acute infectious-inflammatory process, which is achieved is known for these purposes, antiviral and antiseptic, but also prevent recurrence of the disease due to the stimulation of local immunity.
You know the tool Inhalt containing streptocid soluble norsulfazol, thymol, eucalyptus and peppermint, alcohol, sugar, glycerol, tween-80 and water. Inhalt has antiseptic and anti-inflammatory effect and is used to tonsillitis, pharyngitis, laryngitis, and ulcer aphthous stomatitis (M. D. Mashkovsky "Drugs" Vilnius, 1993, H. 2, S. 245-246).
The closest in technical essence and the achieved result for the proposed tool can be considered as a tool for oromucosal injection in the treatment of infectious-inflammatory diseases of the oropharynx, containing interferon (US 2010/0111902 A1, 06.05.2010). However, this tool does not solve the problem of preventing recurrence of the disease due to the stimulation of local immunity.
Solved by the invention of the task and the expected technical result are the development of medicines for oromucosal route of administration in the form of absorbable tablets not only for treatment of acute infectious-inflammatory diseases of different etiology of upper respiratory tract, oral cavity and pharynx complex is ondastan on the body, but for prevention of repeated cases of these diseases, especially in immunocompromised patients due to the stimulation of nonspecific resistance of the organism, as well as local immunity.
To achieve the technical result of the pharmaceutical composition in tablet form for oromucosal injection in the treatment of infectious-inflammatory diseases of the oropharynx, according to the invention, contains recombinant interferon selected from the group: recombinant interferon-alpha, interferon-beta, interferon-gamma; amino acid selected from the group: arginine, histidine, glycine, glutathione, lysine, methionine, cysteine; antiseptic, a preservative, an aromatic substance selected from the group of: tea tree oil, oil of leaves of eucalyptus, oil of peppermint, and consistentread the basis of the following ratio of components, in g per 1 g of a mixture of:
|recombinant interferon IU||100-10000000|
|amino acid||within 0.00001 to 0.5|
|antiseptic||within 0.00001 to 0.5|
|preservative||within 0.00001 to 0.5|
|aromatic substances||within 0.00001 to 0.5|
This pharmaceutical composition comprises a preservative selected from the group: lysozyme, bilateral, fusafungine, Amazon, benzyldimethyl-myristoylation-Propylamine, co-trimoxazole, amylmetacresol, dichlorobenzoyl alcohol, cetylpyridinium chloride, benzocaine chloride, chlorhexidine.
Optionally, the pharmaceutical composition may contain glycyrrhizinic acid or its salts in a quantity within 0.00001-0.5 g, and lecithin in an amount within 0.00001-0.5 g or dextran 60000 in number within 0.00001 to 0.5,
Optionally, the pharmaceutical composition may contain vitamins selected from the group of: beta-carotene, vitamin C, vitamin E, b vitamins: B1, B2, B5, B9, B13 in number within 0.00001 to 0.5,
As the preservative used is selected from the group of: benzalkonium chloride, parabens, boric acid in the amount of 0.0001-0.1 g, benzyldimethyl-myristoylation-Propylamine, benzoic acid, sodium benzoate.
As consistentarea framework contains components selected from the group: thiomersal, lactose monohydrate, mannitol, povidone, citric acid (anhydrous), magnesium stearate, microcrystalline cellulose, carmellose, talc.
The claimed means in the form of tablets intended for the prevention and treatment of nfection-inflammatory diseases of different etiology (angina, pharyngitis, chronic tonsillitis, acute respiratory diseases) by oromucosal introduction.
The dose for adults is 1 tablet 4-6 times a day.
The dose for children is 1 tablet 2-3 times a day.
Spent an analysis of the prior art, including searching by the patent and scientific and technical information sources, and identify sources that contain information about the equivalents of the claimed pharmaceutical compositions, has allowed to establish that the petitioners have not found a similar, characterized by signs, identical to all the essential features of the claimed pharmaceutical compositions.
The present invention is illustrated with specific examples of implementation, which, however, are not only possible, but clearly demonstrate the possibility of achieving the desired technical result.
Example 1. Getting a tablet form. Take interferon selected from the group of recombinant interferon-alpha, interferon-beta, interferon-gamma, amino acid selected from the group: arginine, histidine, glycine, glutathione, lysine, methionine, cysteine, antiseptics selected from the group: bilateral, fusafungine, Amazon, benzyldimethyl-myristoylation-Propylamine, cotrimoxazole, amylmetacresol, dichlorobenzyl the new alcohol, cetylpyridinium chloride, menoxenia chloride, chlorhexidine and aromatic substances selected from the group of: tea tree oil, oil of leaves of eucalyptus, oil of mint leaves. Mix these components with acceptable for this form consistentarea basis and tabletirujut mixture in a known manner.
These components take the following ratio of components in g per 1 g of a mixture of:
|option 1||option 2||option 3|
|recombinant interferon, ME||100||10000||10000000|
|the con is stenobrachius base||the rest is up to 1 g|
Example 2. Carried out analogously to example 1. Additionally, the composition of the claimed compositions include glycyrrhizinic acid or its salts in a quantity within 0.00001 to 0.5,
Example 3. Carried out analogously to example 1. Additionally, the composition of the claimed compositions include lecithin in the amount within 0.00001 to 0.5,
Example 4. Carried out analogously to example 1. Additionally, the composition of the claimed compositions comprise dextran 60000 in number within 0.00001 to 0.5,
Example 5. Carried out analogously to example 1. Additionally, the composition of the claimed compositions include vitamins selected from the group of: beta-carotene, vitamin C, vitamin E, b vitamins: B1, B2, B5, B9, B13 in number within 0.00001 to 0.5,
Treatment and prevention of infectious-inflammatory diseases of the oropharynx conducted in 50 patients aged 12 to 60 years. Included patients with various diseases of the oropharynx: stomatitis viral and bacterial etiology, pharyngitis, tonsillitis, acute respiratory infections. In the acute period of the disease in the treatment included the proposed tablets at a dose of 4-6 times a day. As a rule, acute symptoms were relieved in 3-4 days. However, in immunocompromised patients with frequent recurrences of acute respiratory infections, stomatitis, tonsillitis history treatment tablets continued for 10-14 days. 32 people were under observation during the course the e year, disease recurrence was not. In 23 of them, treated these tablets, the estimation of local immunity.
By radial immunodiffusion in gel was determined by the concentration of immunoglobulins A, G and lysozyme activity values method. Given that the most important gateway for the penetration of pathogenic microorganisms in the human body are the upper respiratory tract, in particular the mucous membrane, the estimation of local immunity prognostically significant. Indicators of lysozyme in the mucous averaged 6,83 µg/ml, sIgA - 549 mg/l, AsIgA - 0,089, suggesting a low degree of immune stress. After treatment these figures gradually came to normative values. To assess the state of local immunity was also used method smears, fingerprints from the mucous membrane of the nose.
Known studies confirm the effector function of neutrophils, which were the first to enter an inflammatory response, thereby making protection against bacterial agents. In this regard, to assess the state of local immunity we also used the method of smears, fingerprints from the mucous membrane of the nose. For the studied patients were characterized by destructive changes in the epithelial cells that determine adaptive reserve of local immunity in viral and other intracellular infections. Dynamic observation showed that during treatment with tablets and inflammation the number of modified neutrophils and epithelial cells was decreased, increased the percentage of cells with normal morphology.
Example 1. Patient, 30 years. Diagnosis: tonsillitis, pharyngitis, rhinitis. Complaint: pain in the fauces, headache, weakness, fever. History of frequent colds, acute tonsillitis.
When the examination is marked hyperemia and infiltration of heaven and palatal arches, signs of rhinitis, purulent follicles and caseous plugs in the gaps, increasing the submandibular lymph nodes. In addition to General symptomatic treatment, the patient was treated by the proposed tablets 1 tablet 5 times a day for 14 days. Each tablet firmly fixed on the sky and disappeared within 1.5 hours.
After treatment of the stated means of subjectively noted the rapid disappearance of unpleasant sensations in the oropharynx in the form of pain, burning and sore after an average of 3 days. Disappeared hoarseness, at the same time noted improvement in General condition disappeared weakness, headache, appetite improved. Objectively (pharyngoscope) noted the disappearance of hyperemia and infiltration of the Palatine arches (average 2 days) and the disappearance of purulent follicles and caseous plugs in Amanah (average 2 days). Disappeared hyperemia and granularity of the mucosa of the posterior pharyngeal wall, infiltrative changes and swelling of the granules. Positive dynamics from submandibular lymph nodes. For 4-5 hours application of funds marked reduction in size and reduction of morbidity. During the year of colds was not.
Thus, a pharmaceutical composition in the form of the dissolving tablets, expanding Arsenal of known means, has effective properties of complex effects on the body, including the processes of local immunity, providing conditions for rapid relief of acute inflammatory process and prevent recurrence of the disease by increasing the immunological reactivity and non-specific resistance of the organism of the sick.
1. Pharmaceutical composition in tablet form for oromucosal injection in the treatment of infectious-inflammatory diseases of the oropharynx, characterized in that it contains recombinant interferon selected from the group: recombinant interferon-alpha, interferon-beta, interferon-gamma; amino acid selected from the group: arginine, histidine, glycine, glutathione, lysine, methionine, cysteine; antiseptic, a preservative, an aromatic substance selected from the group what s: tea tree oil,
the oil of the leaves of eucalyptus, oil of peppermint, and consistentread the basis of the following ratio of components in g per 1 g of a mixture of:
|recombinant interferon IU||100-10000000|
|amino acid||within 0.00001 to 0.5|
|antiseptic||within 0.00001 to 0.5|
|preservative||within 0.00001 to 0.5|
|aromatic substances||within 0.00001 to 0.5|
2. The pharmaceutical composition under item 1, characterized in that as an antiseptic contains selected from the group lysozyme, bilateral, fusafungine, Amazon, benzyldimethyl-myristoylation-Propylamine, cotrimoxazole, amylmetacresol, dichlorobenzoyl alcohol, cetylpyridinium chloride, benzocaine chloride, chlorhexidine.
3. The pharmaceutical composition under item 1, characterized in that as preservative contains selected from the group of: benzalkonium chloride, parabens, boric acid in the amount of 0.0001-0.1 g, benzyldimethyl-myristoylation-Propylamine, benzoic acid, sodium benzoate.
4. The pharmaceutical composition is I p. 1, characterized in that it further contains glycyrrhizinic acid or its salts in a quantity within 0.00001 to 0.5,
5. The pharmaceutical composition under item 1, characterized in that it further comprises lecithin in the amount within 0.00001 to 0.5,
6. The pharmaceutical composition under item 1, characterized in that it further comprises dextran 60000 in number within 0.00001 to 0.5,
7. The pharmaceutical composition under item 1, characterized in that it further contains vitamins selected from the group of: beta-carotene, vitamin C, vitamin E, b vitamins: B1, B2, B5, B9, B13 in number within 0.00001 to 0.5,
FIELD: food industry.
SUBSTANCE: biologically active food additive strengthening the organism adaptive power and body defences and having anti-inflammatory and antioxidant activity contains vegetal origin components represented by a complex extract of devil's-club root, Rhaponticum carthamoides root, Hedysarum neglectum Ledeb root, celery roots and leaves, rhodiola rosea root, Japanese angelica tree roots, boschniakia rossica roots, Hungarian sainfoin herb, magnolia-vine fruits; additionally the additive contains chitosan, trepang fermentative hydrolysate, ascorbic acid, taurine, glutathione, nicotinamide, vitamin B1, vitamin B2, vitamin B6, vitamin B12, folic acid, anhydrous calcium chloride, magnesium chloride, zinc chloride, bee honey at preset ingredients ratio.
EFFECT: biologically active food additive promotes effective strengthening of the organism adaptive power and body defences and human aging retardation.
4 tbl, 6 ex
SUBSTANCE: invention relates to medical radiology and can be used for prevention of cerebral form of acute radiation sickness. Claimed is application of officinal drug pyrazinamide as medication for prevention of cerebral form of acute radiation sickness. Pyrazinamide has been used for treating tuberculosis.
EFFECT: preventing in 100% of cases development of early temporary incapacity in case of irradiation in dose 200 Gy, improvement of indices of behavioral and research activities in irradiated animals, in reduction of frequency of motor disorders, reduction of frequency and expression of convulsive-hyperkinetic syndrome and 9,5 fold increase of average life expectancy of irradiated animals Pyrazinamide is not inferior to drug - nicotinamide prototype in efficiency of radioprotective action.
4 tbl, 4 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine and represents a composition possessing the antioxidant and antibacterial activity and containing lithium ascorbate, differing by the fact that it additionally contains lithium benzoate in the following proportions, wt %: lithium ascorbate - 50; lithium benzoate - 50.
EFFECT: invention provides extending the range of antioxidants with antibacterial activity possessing normothymic activity.
1 ex, 2 tbl
SUBSTANCE: method for increasing the antitoxic body function in healthy individuals occupied in the chemical load environment involving administering an antioxidant water containing carrot juice, cod liver oil, olive oil, honey; the water is taken daily before the working shift for 10 days.
EFFECT: using the invention enhances the antitoxic body function by administering the water having high antioxidant properties.
1 tbl, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: what is described is using a pharmaceutical composition in the form of an orally disintegrated tablet containing 6-methyl-2-ethyl-3-hydroxypyridine succinate as an active substance and crospovidone as a disintegrating agent in ratio 2:1 respectively, as a motor stimulating and anorectic agent.
EFFECT: preparing motor stimulating and anorectic agent.
16 dwg, 34 tbl, 13 ex
SUBSTANCE: for the purpose of post-surgical treatment of cerebral tumours, memantine is prescribed in a dose of 10 mg daily for 5-7 days before radiation therapy, and in a dose of 20 mg during radiation therapy 4-6 hours before the radiation session. On completing the course of radiation therapy, memantine is prescribed in patients aged up to 60 years old in a dose of 10 mg for 2-3 months daily, in patients aged 60 and older in a dose of 20 mg for 5-6 months daily.
EFFECT: method enables providing the higher patients' quality of life with a view to cancellation of glucocorticoids, ensuring higher clinical effectiveness ensured by an increase of the medullary substance to radiation.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to the pharmaceutical industry, namely to an agent with an antidyslipidemic and analgesic effect. The method for preparing the phytocomplex with the antidyslipidemic and analgesic effect, involving: a) grinding peeled bergamot fruit to prepare an undegraded mixture, b) introducing pectinolytic enzymes into the mixture; c) reducing pulp content; d) inactivating the above enzymes added at the stage b), to prepare a degraded mixture; e) performing ultrafiltration of the degraded mixture through membranes isolating the substances having a molecular weight of over 30,000 Da, to prepare a transparent solution; f) introducing the transparent solution on a polyphenol absorption column; g) washing the polyphenol absorption column with water and increasing pH to prepare an aqueous polyphenol fraction; h) transmitting the aqueous polyphenol fraction to cationic resin to recover the phytocomplex in an aqueous phase; i) drying the phytocomplex in the aqueous phase. The phytocomplex in the aqueous phase with the antidyslipidemic and analgesic effect. The phytocomplex with the antidyslipidemic and analgesic effect. A pharmaceutical composition with the antidyslipidemic effect containing the phytocomplex, and pharmaceutically acceptable additives. A pharmaceutical composition with the analgesic effect containing the phytocomplex, and pharmaceutically acceptable additives.
EFFECT: phytocomplex described above possesses the evident antidyslipidemic and analgesic effect.
SUBSTANCE: method involves preliminary intraperitoneal single administration of 5% aqueous alloxan in a dose of 15 mg/kg of body weight into a rat's body on an empty stomach. That is followed by administering afobazol under conditions of oxidative stress after observing the rat's blood glucose gain at least twice. Afobazol is administered subcutaneously in a dose of 10 mg/kg of body weight once a day for 30 days with underlying administration of L-arginine in a dose of 10 mg/kg of body weight or with underlying NG-nitroarginine methyl ester (L-NAME)-inhibitor of NOS-3 enzyme in a dose of 25 mg/kg of animal's weight.
EFFECT: method enables correcting the oxidative stress and NO-producing endothelial dysfunction accompanying vascular complications of diabetes mellitus.
1 dwg, 6 tbl, 1 ex
SUBSTANCE: invention concerns an antioxidant representing the amino acid glycine immobilised on the detonation-synthesised nanodiamond particles of 2-10 nm in size.
EFFECT: higher efficacy.
4 cl, 5 dwg, 7 tbl, 3 ex
SUBSTANCE: improving the functional result of a low resection of rectum in the patient suffering from rectum cancer is ensured by prescribing the drug preparation Laviocard+ 1 capsule 2 times a day with food for the pre-operative radiation course, one day before the operation and for 30 postoperative days to the extent of the low resection of rectum.
EFFECT: invention enables reducing a rate and degree of defecation and continence dysfunctions following the low resection of rectum and the radiation therapy.
1 tbl, 1 ex
SUBSTANCE: pathogenetic treatment of chronic tonsillitis and/or hypertrophy of palatine tonsils in preschool children suffering from lymphoproliferative syndrome is ensured by the palatine tonsils debridement. An interleukin-1β(IL-1β) level is measured in the palatine tonsils washing. If the measured value is less than 5.8 pg/ml, recombinant interleukin-1β (IL-1β) is to be administered orally by phonophoresis with the use of the Tonsillor MM apparatus. Two courses of 10 procedures every 14 days are performed. The clinical effectiveness is assessed if observing a positive dynamics of IL-1β measured in the palatine tonsils washing 17 and 41 days after the beginning of the immunomodulatory therapy.
EFFECT: higher clinical effectiveness ensured by the differentiated selection of children for carrying out the immunomodulatory therapy, reducing a rate of infectious involvements of the palatine tonsils in the declared group of patients by the pathogenetically reasoned application of recombinant IL-1β.
3 cl, 2 tbl, 1 ex
SUBSTANCE: present invention refers to medicine. The preparation contains the active substance furacilin (nitrofural, 2-[(5-nitro-2-furanyl)methylen]hydrazine carboxamide), the excipient - sodium chloride, a gas-forming mixture, an acidity regulator for reducing pH from 6.5 to 7.5 and a lubricant if needed. The gas-forming mixture consists of an organic acid and sodium hydrocarbonate. According to the method for preparing effervescent tablets of furacilin, furacilin and sodium chloride are milled in a combination; all the ingredients are placed into a mixer, and the prepared mixture is tabletted by direct compression. The antimicrobial therapeutic preparation of furacilin in the form of effervescent tablets is used for septic wounds, bed sores, small skin damages, including scratch marks, abrasions, cuts; infectious-inflammatory oral and throat diseases, including acute tonsillitis, stomatitis, gingivitis and tonsillitis. The effervescent tablets of furacilin are storage-stable for two years and water-soluble at room temperature for 5 minutes.
EFFECT: preparing the antimicrobial therapeutic preparation in the form of the effervescent tablets used for preparing the solution for local and external application.
4 cl, 6 tbl, 3 ex
SUBSTANCE: biologically active additive Laviocard+ is prescribed orally 1 capsule 2 times a day with food for 21 days. That is combined with daily wound irrigations with neutral analyte of anhydrohexitol nucleic acid with leaving a sterile gauze bandage impregnated with neutral analyte of anhydrohexitol nucleic acid in the wound until it is clean. That is followed by daily bandaging with Lavitol cosmetic dihydroquercetin powder applied on the wound surface 1-2 mm thick until the wound is healed.
EFFECT: reduced length of wound healing by stimulating the regeneration processes in tissues.
1 ex, 3 tbl
SUBSTANCE: inorganic clay, represented by sodium-calcium, and/or calcium and/or ferrous forms of montmorillonite, is modified with a water solution of silver nitrate with a concentration 0.16-9.9 wt % in a weight ratio clay:water solution of silver nitrate 1:5. Modification is carried out with mixing from 3 to 7 hours at a temperature in the interval from 10°C to the temperature of boiling. The obtained material is washed with distilled water to pH ≈6-5, until excess of silver nitrate is removed, stood at room temperature and decanted. The material is dried at a temperature of 20-160°C.
EFFECT: obtaining an efficient antibacterial material for traditional and veterinary medicine.
2 tbl, 5 ex
FIELD: veterinary medicine.
SUBSTANCE: agent for prevention of mastitis in dairy cows in the dry period, characterised in that it contains as ingredients the polymer PVP/VA, silicone, polyhexamethylene biguanide, ethyl alcohol, glycerol - as emollient component, gelation agents - triethanolamine and carbopol and purified water in the following ratio of ingredients, %: polymer PVP/VA 9-10; silicone 5-6; ethyl alcohol 35-40; polyhexamethylene biguanide 0.008-0.01; glycerol 5; gelation agents - triethanolamine and carbopol 0.1; purified water - the rest.
EFFECT: method enables to minimise or eliminate the use of chemotherapeutic agents, antibiotics and their derivatives, sulphonamides, nitrofurans and eliminate the side effect of the agent on animal body, as well as to reduce the number of visits of the veterinarian during the dry period of cows, to improve the preventive efficacy.
1 tbl, 3 ex
SUBSTANCE: invention refers to the veterinary science, particularly to substances used in treating purulent-necrotic involvements of bovine's distal extremities, including digital dermatitis. A preparation for treating bovine digital dermatitis in the form of an ointment consists of an excipient, containing an ointment base, and an active ingredient - zinc oxide and copper sulphate in the following proportions, wt %: zinc oxide 9-11, copper sulphate 35-45, the ointment base - the rest.
EFFECT: invention provides higher clinical effectiveness with cost cutting for the ointment preparation.
SUBSTANCE: invention refers to medicine, namely to otorhinolaryngology, and may be used for the preoperative preparation of the patients suffering a perforated nasal septum. Intranasal silicone splints are placed 10 days before the operation. The splint is incised from one side within a perforation border. A 30° endoscope is used to assist a 7-day daily nasal perforation rinsing with chlorhexidine. A suction unit is used to evacuate mucosal secretion; synthomycin ointment is introduced through the incision in the silicone splint to the perforation region. The nasal cavity is irrigated daily with antiseptic and vasoconstrictive preparations. On the 7th day, the intranasal splints are removed.
EFFECT: method enables relieving the mucosal inflammation within the perforation, promotes the prolonged drug retention in the introduction place, ensures avoiding an overlay of a secondary infection, improves the functional state of ciliated epithelium.
SUBSTANCE: invention refers to medicine, namely to surgical dentistry and maxillofacial surgery, and is applicable in maxillary sinusotomy with fistula repair. A mucous membrane is incised to a bone under an intubation narcosis after a two-fold preparation of a surgical area. A D-shaped flap is cut out within an alveolar socket of an extracted tooth to be extended along a mucobuccal fold of an upper jaw on one side to a second incisor, and on the other side - to a third molar. The flap together with the periosteum is separated and retracted upwards with exposing a canine fossa and the alveolar socket of the extracted tooth. A hole is created within the canine fossa. Pathologically changed tissues or all sinus mucosa is scooped with a bone curette through the created hole. The alveolar socket of the extracted tooth is inspected. After the cavity has been scooped, an artificial hole is created towards a nasal cavity through an inferior nasal meatus. The sinus cavity is packed with a iodoform cotton swab; an end of the cotton swab is laid thoroughly on a sinus bottom, namely within the defect; the end of the cotton swab is brought out into a nose. A mucoperiosteal flap is mobilised within the alveolar socket of the extracted tooth, laid on the alveolar socket; the wound is closed completely. In the postoperative period, the cotton swab is removed from the sinus on the 9-10th day. The sutures are removed on the 10-11th day.
EFFECT: method enables reducing an incidence of recurrent oroantral communications in the postoperative period ensured by a compact packing of the sinus, and the antiseptic and regeneration effect of iodoform on the maxillary sinus.
SUBSTANCE: invention relates to veterinary science, namely to obstetrics and gynaecology. A preparation for treating and preventing sub-clinical, clinical, acute and chronic mastitis in farm and domestic animals contains an active substance that is - triphenyl-(3,5-di-tert-butyl-4-hydroxybenzyl)phosphonium bromide and a pharmaceutically acceptable carrier that is Vaseline in ratio 1:2000.
EFFECT: invention provides the higher antimicrobial effectiveness and the lower toxicity of the ointment with the lower concentration of the active substance.
3 tbl, 5 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to an antiseptic drug with haemostatic action for wound cleaning. The drug contains ingredients in the following ratio, wt %: an antimicrobial substance - 0.01-3, an active complex - 1-25, glycerol - 2-35 and water - up to 100. The antimicrobial substance is specified in a group consisting of cetyl pyridinium or cetyl methyl ammonium halogenide, chlorhexidine, miramistin and other quaternary bases applicable in medical practice to treat burns and to clean open wounds, and the active complex is presented by a haemostatic preparation in the form of a mixed-ligand chelated complex of zinc, ethylene diamine tetraacetic acid and ε - aminocapronic acid. The invention also refers to a method for preparing the antiseptic drug with haemostatic action. The method consists in the fact the active complex is prepared in a water-glycerol mixture while stirring by dissolving ε - aminocapronic acid, then zinc oxide, adding powdered ethylene diamine tetraacetic acid and after dissolved completely, adding a liquid solution of the antimicrobial substance in the water-glycerol mixture.
EFFECT: preparing the antiseptic drug with haemostatic action for wound cleaning.
2 cl, 9 ex
SUBSTANCE: inventions refers to medicine, namely to pulmonology, and can be used for treating a pulmonary disorder in a patient. That is ensured by administering an effective dose of the nebulised liposomal amikacin formulation of 100 to 2,500 mg daily within the cycle of treatment, which involves the period of administration from 15 to 75 days and the following withdrawal period from 15 to 75 days. The cycle of treatment repeats at least twice.
EFFECT: invention provides improving the pulmonary function, which is supported for at least 15 days after the termination of treatment, and increasing the one-second forced expiratory volume (FEV1).
28 cl, 16 tbl, 11 dwg, 3 ex