Method for ferrocene encapsulation

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry and represents a method for drug encapsulation by non-solvent addition; the method is characterised by the fact that the above drug is presented by ferrocene, while a coating is carrageenan precipitated from a butanol solution by adding ethanol as a non-solvent and water at room temperature.

EFFECT: invention provides simplifying and accelerating the microencapsulation process, reducing the microencapsulation loss (higher weight yield).

2 ex, 2 dwg

 

The invention relates to the field of encapsulation.

Previously known methods for producing microcapsules of salts.

In Pat. 2359662, IPC A61K 009/56, A61J 003/07, B01J 013/02, A23L 001/00 published 27.06.2009, the Russian Federation proposed a method of producing microcapsules of sodium chloride with the use of spray cooling in the spray tower Niro under the following conditions: air temperature at the inlet 10C, the temperature at the outlet 28C, the speed of rotation of the spray drum 10000 rpm Microcapsules according to the invention have improved stability and provide adjustable and/or prolonged release of the active ingredient.

Disadvantages of the proposed method are the duration of the process and the use of special equipment, a set of conditions (temperature of inlet air 10C, the temperature at the outlet 28C, the speed of rotation of the spray drum 10,000 rpm).

The closest method is the method proposed in U.S. Pat. 2134967, IPC A01N 53/00, A01N 25/28 published 27.08.1999, Russian Federation (1999). Water is dispersed solution of a mixture of natural lipids and a PYRETHROID insecticide in the weight ratio of 2-4:1 in an organic solvent, which leads to simplification of the method of microencapsulation.

The disadvantage of this method is the dispersion in the aquatic environment, which makes the proposed the manual is not applicable to obtain microcapsules of water-soluble drugs in water-soluble polymers.

The technical objective is the simplification and acceleration of the process of production of microcapsules, the reduction of losses upon receipt of the microcapsules (increase in mass).

The solution of the technical problem is achieved by the method of encapsulation of ferrocene, characterized in that as the shell of the microcapsules is carragenan when receiving the encapsulated particles by precipitation with nerastvorim with the use of ethanol as a precipitator, the process of production of microcapsules is carried out without special equipment.

A distinctive feature of the proposed method is to obtain microcapsules by precipitation with nerastvorim using ethanol as a precipitator, and the use of carrageenan as a shell particles, which have a supramolecular properties.

The result of the proposed method are obtaining microcapsules salts in the water-soluble polymer shell.

In Fig.1 - confocal image of the fractal composition from a solution of microcapsules of ferrocene in the shell carrageenan at a concentration of 0.5%, the increase in 2830 times.

In Fig.2 - confocal image of the fractal composition from a solution of microcapsules of ferrocene in the shell carrageenan at a concentration of 0.25% will: (a) increase in 505 times, b) the increase in 620 times) increase in 930 times, g) increase in 1200 time, d) the increase in the 1770 times e) increase in 2830 times.

EXAMPLE 1. Obtaining microcapsules of ferrocene in carragenine

A suspension of 100 mg of ferrocene in 2 ml of butanol was dispersed in a solution of carrageenan in butanol containing 300 mg of the polymer in the presence of 0.01 g of the drug Is (ester of glycerol with one or two molecules of dietary fatty acids and one or two molecules of citric acid, and citric acid as Tihonova can be etherification other glycerides and as oxanilate - other fatty acids. Free acid groups can be neutralized with sodium) under stirring 1200 Rev/sec. Then poured 5 ml of ethanol and 0.5 ml of water. The resulting suspension is filtered and dried at room temperature.

Received 0,368 g of powder of microcapsules. The yield was 92%.

EXAMPLE 2. The study of self-organization of the particles from solutions

From a powder of microcapsules obtained by the method described in example 1, there were prepared aqueous solutions of concentrations 1%, 0,5%, 0,25%, 0,125% etc., by dilution of the solution twice. A drop of each of the prepared solutions were placed on a glass slide prior to complete drying and the dried surface was carried out confocal scanning microscopy.

Thus, the obtained microcapsules of ferrocene with high yield without special equipment within 10 minutes Obrazovanie.igraju occurs spontaneously due to non-covalent interactions and this suggests that they are characterized by self-Assembly. Presented on Fig. 1, 2 structures are ordered, then they have the self-organization. Therefore, encapsulated by carrageenan ferrocene has supramolecular properties.

The obtained microcapsules salts with high outputs. The proposed method is quite suitable for application on an industrial scale due to minimal losses and ease of execution.

The method of encapsulation of a medicinal product by precipitation with aristotelem, characterized in that the medicinal product is used ferrocene, as the shell - carrageenan, which precipitated from solution in butanol by adding as herstories ethanol and water at room temperature.



 

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