Method for oxidative stress correction in preventing and treating iron-deficiency anaemia in calves exposed to chronic incorporated radiation

FIELD: medicine.

SUBSTANCE: invention refers to veterinary science, namely to clinical pharmacology and veterinary therapy. The method consists in administering the complex iron-dextran preparation Ferranimal-75M intramuscularly on the 5th day of calf's life in a dose of 3 ml in a combination with an intramuscular injection of the preparation Hydropeptone in a dose of 10 ml. Ferranimal-75M is injected 10 days later in a dose of 2 ml in a combination with an injection of Hyropeptone 5 ml intramuscularly in different points.

EFFECT: method provides higher antioxidative activity of calf's blood serum, reduced pro-oxidant action of iron and incorporated radionuclides, as well as higher iron accessibility in treating and preventing iron-deficiency anaemia in calves exposed to the chronic incorporated radiation.

 

The invention relates to the field of veterinary medicine, namely clinical pharmacology and therapy animals, relates to a method for the treatment and prevention of diseases of animals caused by a deficiency in their body iron, and correction side effects of iron supplements.

Iron plays an important role in the life of humans and animals. Change its contents can lead to various pathological conditions: iron deficiency develops iron deficiency anemia, whereas the excess of it causes hemochromatosis and hemosiderosis with severe lesions of various organs and systems. Causes of iron deficiency anaemia varied. It can be: "poverty" iron depot when insufficient the flow of food; increased the body's need for iron; inadequate absorption of iron in the gastrointestinal tract; excessive loss of iron by the body and other reasons. It is also known that in animals under conditions of constant incorporated exposure (ingestion of radionuclides in the body of the animal with food, dwelling in areas contaminated with radionuclides), there is a significant decrease in the concentration of iron in proteins of the bone marrow, resulting in impaired synthesis of hemoglobin and, therefore, reduced hemoglobin content in erythrocytes, at the same time, what about the decrease in the number of erythrocytes, that leads to the development of nutritional (iron deficiency) anemia [1].

For the treatment and prevention of nutritional anaemia in farm animals using iron supplements. Known drug usage Farmanimal-75 (synonym of Feroglobin-75), a colloidal solution of a complex of ferric hydroxide with low molecular weight dextran in water, for the prevention and treatment of iron deficiency anemia in all species of farm animals and fur-bearing animals [2]. The disadvantage of this drug before the drug, the proposed method is the absence in the composition of the trace elements copper and cobalt, contributing to increased absorption of iron, and also stimulating haematopoiesis, and the lack of selenium has antioxidant properties.

The prior art method of correction of antioxidant activity of the liquid portion of the blood of newborn calves with iron deficiency anemia, including the use of a solution Feroglobin-75 intramuscularly once daily in combination with oral application of glicerina [3]. The disadvantage of this method, selected as a prototype, is its application only to new-born calves with already developed anemia, which does not allow to use this method on other age groups of calves and to use this method to prevent anemia, and t is the train this method does not take into account prooxidant properties of iron, part of the preparation. In the proposed method, the correction is possible in the prevention and treatment of anemia, and applicable on the calves of different age groups (newborn calves, calves suckling period). In addition, our proposed method of correction of oxidative stress refers to animals under chronic incorporated irradiation.

One of the disadvantage of this method is the lack of essential amino acids contained in the hydrolyzate of soybean protein used in the inventive method.

The technical result of the claimed invention is to increase the antioxidant activity of the blood serum of calves, reduced prooxidant action of iron and of incorporated radionuclides, as well as increasing the absorption of iron in the treatment and prevention of iron deficiency anemia in chronic conditions incorporated irradiation.

The objective of the invention is to provide a method for correcting the level of antioxidant activity of blood serum and of lipid peroxidation in the prevention and treatment of iron deficiency anemia calves in conditions of chronic incorporated irradiation.

For the correction of oxidative stress in the prevention and treatment of iron deficiency anemia calves in conditions of chronic incorporando what about the radiation used drug Farmanimal-75M (active ingredients: iron (III) 75 mg dextranomer complex, 0.10 mg of copper (II) in dextranomer complex, 0.20 mg of cobalt (II) in dextranomer complex, 0.05 mg selenium(IV) stable [4]) in combination with Hydropeptide - hydrolyzed soy protein compensated for methionine in the form of solution for injection use, which contains all the essential amino acids and lower peptides. The simultaneous appointment of protein hydrolysate stimulates velocimeters function of the body, promote the absorption of trace elements entering into the composition of the drug Farmanimal-75M, while reducing their prooxidant actions and increase antioxidant activity in the blood serum. It is also possible supplemental vitamin B1 in the dose of 2.5 mg and vitamin PP in a dose of 3.7 mg

This technical result is achieved in the following way. To increase the antioxidant activity of blood serum, lower level of lipid peroxidation and increase the absorption of iron appoint injected intramuscularly on days 3-5 of life drug Farmanimal-75M dose of 3 ml, and then repeat injection after 10 days at a dose of 2 ml, simultaneously with the first injection Farmanimal-75M intramuscularly in another place impose drug Hydropath in the dose of 10 ml simultaneously with the second injection Farmanimal-75M, also intramuscularly in another place impose drug Hydropath at a dose of 5 ml

The method is as follows. The calf in the appointment injected intramuscularly on days 3-5 of life zhelezobaktery drug Farmanimal-75M dose of 3 ml, and then repeat injection after 10 days at a dose of 2 ml, simultaneously with the first injection Farmanimal-75M, intramuscularly in another place impose drug Hydropath in the dose of 10 ml, representing a protein hydrolysate compensated for methionine, simultaneously with the second injection Farmanimal-75M, also intramuscularly in another place impose drug Hydropath at a dose of 5 ml

As a result of application of this method found that when radiation absorbed dose for internal radiation, equal to 12-18 mGy/year137Cs, on the 15th and 25th day of life calves significantly increased level of antioxidant activity of blood serum, and decreased the number of primary products of lipid peroxidation. So the number of diene conjugates on the 15th 0.6% opt.PL/ml and in the control of 1.1% opt.PL/ml, on the 25th day, the number of diene conjugates constituted 0.7% of the protected area.PL/ml and in the control of 1.3% opt.PL/ml Number tranovich conjugates on the 15th was 0.3% opt.PL/ml and in the control of 0.8% opt.PL/ml, on the 25th day, the number tranovich conjugates amounted to 0.4% of the protected area.PL/ml and in the control of 0.9% opt.PL/ml Number oxadiazole conjugates on the 15th 0.5% opt.PL/ml and in the control of 1.1% on the so PL/ml, on the 25th day, the number oxadiazole conjugates was 0.5% opt.PL/ml and in the control of 1.0% of the protected area.PL/ml Number of Schiff bases on the 15th 0.5% opt.PL/ml and in the control of 1.3% opt.PL/ml, on the 25th day, the number of Schiff bases amounted to 0.6% of the protected area.PL/ml and in the control of 1,4 units of the Park.PL/ml Level of antioxidant activity on the 15th day life in the blood serum of calves from the experimental group amounted to 18.0±1,2%, while in the control group calves level of antioxidant activity was significantly lower and amounted to 13.6±0.9 per cent. After the second injection the level of antioxidant activity continued to increase and amounted in the experimental group and 24.6±3.6%, and in the control of 15.3±1,1%.

As can be seen from the presented data, in animals treated according to the proposed method in comparison with control, significantly higher level of antioxidant activity of blood serum and below the level of the primary products of peroxidation, indicating a high activity of the claimed method for use in the treatment and prevention of iron deficiency anemia in chronic conditions incorporated irradiation.

The use of the proposed method of correction of the level of antioxidant activity of blood serum and of lipid peroxidation in the prevention and treatment of iron deficiency anemia calves in conditions of chronic inkorporira the aqueous exposure will help to avoid the negative effects of ferreteria and reduce the impact of chronic incorporated irradiation, interferes with normal absorption of iron and contributing peroxide oxidation of lipids, which increases the health, productivity and growth of animals, renders prophylactic action onset of the disease and reduces recovery time.

Literature

1. A. N. Urazaev, A. A. Dealers, L. P., Parasyuk, R. D. Urazayeva. The biological role of iron. The use of iron preparations in veterinary medicine: a monograph. - M.: Kolos, 2010, - 17 S., 41 C., 50 C.).

2. Found on the Internet: http://webmvc.com/vet/leki/17/abio/ferran.php.

3. The patent RU 246910 C1, publ. 20.12.2012.

4. Found on the Internet: http://www.vetlek.ru/directions/7icH646.

The correction method of oxidative stress in the prevention and treatment of iron deficiency anemia calves in conditions of chronic incorporated irradiation, including the introduction of a comprehensive geisterstreiber drug Farmanimal-75M, intramuscularly, on the 5th day of life of the calf, at a dose of 3 ml, along with intramuscular injection of the drug Hydropath in the dose of 10 ml, and the injection Farmanimal-75M repeated after 10 days at a dose of 2 ml, simultaneously with the injection of 5 ml of Hydropeptide, intramuscularly in different places.



 

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5 cl, 1 tbl, 2 ex

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