Method of treating initial caries involving preliminary assessment of reversible abnormal changes of enamel accompanying early cariosity
SUBSTANCE: method involves preliminary assessment of the reversible abnormal changes of enamel accompanying early cariosity. That is ensured by diagnostic tests of solid dental tissues conducted by using light-induced fluorescence and electrometric measurement techniques followed by therapy involving daily applications of the Radogel-GABA preparation. If observing visually detected changes with a current intensity of 0.21-1.99 mcA in the lesion and the presence of fluorescence, the preclinical changes of enamel are diagnosed requiring 5 therapeutic procedures with the above preparation. Visualised tarnishing of enamel accompanied by a current intensity of 2.00-3.99 mcA in the lesion and the presence of fluorescence, an early carious change of enamel at the stage of a dead spot is diagnosed, and 7 therapeutic procedures are conducted. If visualising a white spot of enamel accompanied by a current intensity of 4.00-5.99 mcA in the lesion and the presence of fluorescence, an early carious change of enamel at the stage of a white spot is diagnosed, and 10 therapeutic procedures are conducted. If visualising a white spot of enamel accompanied by a current intensity of 6.00-7.99 mcA in the lesion and the presence of fluorescence, an early carious change of enamel at the stage of an intense white spot is diagnosed, and 15 therapeutic procedures with the Radogel-GABA preparation are required.
EFFECT: method provides the high-effective therapeutic exposure on caries by the timely recovery of the protein dental matrix with simplicity and ease of use at massive dental visits.
The invention relates to medicine and can be used in practical health care in mass screening of patients for pre-clinical and early clinical diagnosis and treatment of initial caries using objective instrumental methods of examination and individualized treatment regimen.
It is known that early diagnosis of pathology of the hard tissues of the teeth can cut the development process at an early stage, which increases the quality of dental care [Sadovsky centuries the Use of high-tech methods in the diagnosis of diseases of the teeth / in. A. Sadowski, I. A. space through defence, B. R. the Shumilovich // Institute of dentistry. - 2008. No. 1. - S. 74-75. Modern methods of diagnostics and treatment of dental diseases / A. A. Kunin, L. I. lepekhina, C. A. Nekrasov, S. N. Pankov, I. A. Space Through Defence, B. R. The Shumilovich. - Voronezh, 2001. - 24 S. textbook stamped ULV].
Known methods luminous diagnosis of the early stages of dental caries using fiber optic light (FOL) in clinical karjalohja diagnostic purposes [Axelsson P. Diagnosis and risk prediction of dental caries/P. Axelsson // Quintessence Publishing. - 2000. - 307 p]. The study was conducted in a dark room with a light guide made of organic glass, attached to a dental mirror. The method of transillumination is, is that the tooth is illuminated with light and carious defects appear as dark spots. The effect is based on different porosity and the difference of the refractive index of light in healthy and diseased tissues.
However, transilluminated method does not allow to assess the surface condition of the affected area and set its depth. The presence of seals on the tooth significantly complicates diagnosis using this method.
Another diagnostic method for detection of caries based on light, a luminescent somatoscope [Kunin, A. A. dependence of the optical characteristics of hard tissues of a tooth from its morphological and chemical structure / Kunin, A. A., Moiseev, N. S., Kunin D. A. // journal of the Institute of dentistry (jubilee issue). Materials dental Congress on precautionary, preventive and personalized dentistry under the EPMA, dedicated to the 55th anniversary of the faculty of dentistry, ugma them. N. N. Burdenko, No. 3 (15), November, 2012], is based on the phenomenon of the effect of luminescence of hard tissue of teeth, arising under the influence of ultraviolet irradiation. The study was conducted in a darkened room, aiming at the dried tooth surface a beam of ultraviolet rays. The analyzed surface cover at a distance of 20-30 cm quartz lamp with a filter of dark purple glass. In the ultraviolet rays of healthy teeth flyuorestsiruyut snow-b is small shade and decayed areas and artificial teeth look darker with clear contours.
However, fluorescent somatoscope too time-consuming to conduct mass dental reception. In addition, its implementation is much more difficult, as it requires a special dental equipment. The disadvantages of the method also applies a low percentage of the reliability of the research.
Another diagnostic method is a method of diagnosis of caries, which is based on laser fluorescence [LussiA., Hibsi R., Paulus R. DIAGNOdent: an optical methods for caries detection //J. Dent. Res. - 2004. - Vol.83, Spec. Iss. C. - P. 80-83, Zaitseva E. C. Development of method for fluorescent diagnostics of hard tissues of the tooth with a carious lesion (experimental clinical research): Dis. Kida. the honey. Sciences. M - 2000. - S. 188, Morozova O. A. Experimental validation of the Express-method of laser fluorescent diagnostics of diseases of microbial nature: author. dis. Kida. the honey. Sciences. M - 2001. - C.-25]. The method consists in the irradiation of the tooth using a laser diode and a wavelength of 655 nm and the power light is less than or equal to 1 mW. Allows to detect the initial fissure caries and vestibular surfaces of the teeth, but the high cost of dental equipment and the complexity of the procedures for the preparation, consisting in cleaning the tooth before diag is asticheskoe manipulation, do not allow to implement it everywhere. The above methods are most effective when clinically detectable caries process, to clarify the extent defeat the purpose of monitoring the results of prevention and treatment. Data diagnostic methods do not take into account subtle reversible changes of enamel occurring on the pre-clinical stage development of the caries process.
With regard to the methods of caries prevention, known methods remineralizing effects of drugs on the basis of calcium and fluoride on the hearth affected the enamel surface, such as a 10% solution of calcium gluconate 2% solution of sodium fluoride. However, treatment-and-prophylactic therapy of the initial decay time-consuming, as it requires at least 30 applications preventive medication every day and not always effective, because it is proved by the lack of positive effects of fluoride on the enamel of the teeth of patients aged 18 years and older [Cahen et al. //Community Dent Oral Epidemiol, 1982, 10: 238-241, Kunin, A. A. et al.//Clinical dentistry, №4(36) 2005: 60-63].
Another preventive method over the initial decay is the use of drugs of amino silver ("Saforide" company "Too Seiyaku, Argent one-component" company "Vladiv"), combining the antimicrobial effect of silver ions with the effects of fluoridation and seal the enamel. Report, is that a 3-5 daily applications of amino silver twice a year allows you to achieve a 54% reduction of caries. Negative effects of drugs of silver is considered sustainable change in color of the treated tissue of the tooth to black [Popruzhenko T. C. Prevention of dental caries with the use of products containing fluoride, calcium and phosphate: textbook.-method. manual /So Century. Popruzhenko, M. I. Klenovsky. - Minsk: bgmu, 2010. - S. 42-43].
The technical result - the development of ways to improve the efficiency of diagnosis and primary prevention of dental caries with high precision grade, reversible changes of enamel on the pre-clinical stage development of the caries process. The method is distinguished by the simplicity of performing diagnostic procedures, usability techniques for mass dental reception due to the combined use of two diagnostic methods - svetoindutsirovannoi fluorescence and conductivity, as well as highly effective therapeutic and preventive therapy aimed at restoring the protein matrix of the tooth.
The proposed method for early diagnosis and prevention of dental caries is as follows.
To assess the fluorescence of hard tissue surface visually intact teeth are dried by a stream of air. Then, in the mode of emission of green color at a wavelength of not less than 530 nm, illumination not less than 10 000 Lux, with the density of the radiation power of 140 mW/cm
In addition to fluorescence for research use electrometric apparatus, for example, "Dentist" CJSC "Geosites, Russia. For measuring conductivity of the enamel surfaces of the teeth: the vestibular surface, cutting edge, chipped enamel, cervical region, intact another border with seal - thoroughly dried by turondale and air jet. Sensitivity set on the instrument panel not less than 1:100. Passive electrode, which is dental mirror, placed in the mouth, ensuring good contact with the soft tissues of the oral cavity. In microspec, displacement, for example, 2 ml, which acts as the active electrode, trying to enter the electrolyte solution consisting of a 0.9% physiological solution of sodium chloride and glycerine in equal proportions 1:1, so that at the end of the needle formed a meniscus of the electrolyte. The active electrode is set to a thoroughly dried investigated area of the tooth, the readings recorded. The measurements were carried out at constant voltage of at least 4.26 deaths Volts, and the results of measurements per is read in microampere.
According to the manufacturer's instructions for the size range of indicators electrodiagnostic apparatus "DENTIST" the following: 0 to 0.2 µa - intact mineralized enamel; 3.9 to 7.9 MCA - initial caries; 8,0-27,7 MCA - surface caries; 27,8-50 µa average caries; more 50,0 MCA - deep caries.
The manufacturer's instructions does not interpret the gradation state of the enamel in the range of the current strength of 0.2-3.9 μa, which prompted us to develop our own classification. In the process of the research work declared by the manufacturer in the range 0-0,2 µa fluorescent glow, we did not observe. When 0,21-3,99 MCA degree luminosity was increased in direct proportion to the value of the current intensity in the lesion, which allowed us to develop our own data table, which evaluates the presence of luminescence (see tab.1).
The ratio of state to tooth enamel and measurement readings of current and fluorescence
|The condition of the enamel||The average value of the current strength in the lesion (µa)||Light-induced fluorescence (530 nm) strengthening glow|
|Preclinical changes EMA and||0,21 - 1,99|
|Initial changes enamel|
|matte stain||2,00 - 3,99|
|white spot||4,00 of 5.99|
|intense white spot||6,00-7,99|
From table 1 it is seen that the fluorescence of damaged tissues is only when damage to the enamel, healthy tooth tissue fluorescence is absent.
Healthy enamel - insulator, increasing the digital readout electrometric device indicates the presence of caries process.
Patients with diagnosed using diagnostic instruments initial carious process - pre-clinical, frosted, white or bright white carious changes enamel is directed at treatment and preventive therapy drug "Radael-GABA containing essential amino acids and hyaluronic acid.
Remineraliziruyuschy gel Radael-GABA" domestic developments, water-based contains a range of essential amino acids: lysine 0.3%, arginine 1,2%, histidine 0,1%, the optimal ratio which gives the content of inorganic fillers component of tooth properties of the osmotic membrane, a natural fabric barrier for microorganisms.
The presence of ions of calcium together with vitamin D contributes to the formation of the mineral component of the tooth, strengthening the enamel. Formulated with vitamin B12 activates the processes of mineral metabolism in the enamel. Hyaluronic acid (0,5%), together with the amino acid contributes to the formation of a tissue barrier besprizornyh spaces enamel.
The prevention of dental caries was carried out according to the following procedure: teeth with a focal demineralization identified methods and Electrometry svetoindutsirovannoi fluorescence, isolated from saliva. The surface of the affected teeth mechanically cleaned of soft plaque, were treated with an antiseptic solution, such as 5% solution of hydrogen peroxide or 3% sodium hypochlorite solution, and dried by a stream of air. On the prepared surface of the affected enamel inflicted drug "Radael-GABA" according to the manufacturer's instructions and left on the tooth surface for 25-30 minutes. The remnants of the gel was removed with a cotton swab. The course of treatment was for preclinical changes enamel, amperage of 0.21 - 1.99 MCA and the presence of fluorescence - 5 procedures for carious changes on stage matte stains, amperage 2,00 - 3,99 MCA and the presence of fluorescence - 7 procedures; for carious changes at the stage of white spots, the power toka,00 - 5,99 MCA and the presence of fluorescence - 10 procedures; for carious changes at the stage of intense white spots, amperage 6,00 - 7,99 MCA and the presence of fluorescence - 15 appliqués, held every day.
In the Center of individual prevention-based dental clinic Voronezh state medical Academy named. N. N. Burdenko conducted a comprehensive clinical dental examination 50 patients. According to a survey of somatic pathology in the acute stage of the surveyed were not. Identified pre-clinical and early clinical carious changes enamel using svetoindutsirovannoi fluorescence and Electrometry, then surveyed the patients were divided into two groups. The first group included 20 patients, prophylaxis was performed according to the proposed scheme, select the number of treatments using therapeutic and prophylactic drug therapy "Radael-GABA". In the second group, consisting of 30 people, medical therapy was performed according to the standard scheme with a 2% solution of sodium fluoride (see tab.2).
The dynamics of the patient depending on patterns of use of preventive and curative drug
|The condition of the enamel||To the l-in procedures||is Electrometry in the lesion (µa)||Patients ' complaints|
|before therapy||after therapy|
|The proposed method|
|Preclinical changes enamel||5||1,2||0||no|
|Early clinical changes enamel||matte stain||7||2,5||0||no|
|intense white spot||15||6,5||0,1||no|
|The known method|
|Preclinical changes enamel||-||-||-||-|
|Early clinical changes enamel||matte stain||15||2,5||0||unpleasant taste, increased salivation after 7-8 procedures|
|white spot||15||4,5||0,09||unpleasant taste, increased salivation after 7-8 procedures|
|intense white spot||15||6,5||0,1||unpleasant taste, increased salivation after 7-8 procedures|
Table 2 shows that as a result of preventive and curative treatment of the proposed method achieved a marked positive therapeutic effect, clinically proven results of the diagnostic methods - svetoindutsirovannoi fluorescence and electromedical diagnostics. A detailed study found that patients treated in a known manner, on the stages of the treatment complained of unpleasant is sushenya in the mouth, increased salivation during the procedure and dryness in the mouth after 3-4 hours after its execution. In the study group, which used a differentiated scheme dosed treatment-and-prophylactic drug, complaints were absent.
Thus, the use of the proposed differential scheme for the diagnosis and treatment of initial caries in contrast to the known increases the effectiveness of early diagnosis of caries detection of preclinical forms of caries process, thereby eliminating low-quality diagnostics and contributing to the early prevention of dental caries.
The method of treatment of initial caries, including preliminary assessment of reversible changes of enamel in the initial stages of the carious process, characterized in that conduct diagnostic testing of hard tissues of teeth using svetoindutsirovannoi fluorescence and Electrometry, and subsequent therapy by daily applications of the drug "Radael-GABA", and in the absence of visually detectable changes amperage in the lesion of 0.21-1.99 MCA and the presence of a fluorescent glow diagnose preclinical changes in enamel and spend 5 therapy procedures specified medication; when visually detectable loss of gloss enamel, amperage in the lesion 2,00-3,99 MCA and the presence of fluore the interest of the glow diagnosed early initial carious changes enamel - stage matte spots and spend 7 therapy procedures; when visually defined white spot enamel amperage in the lesion of 4.00 to 5.99 × µa and the presence of a fluorescent glow diagnosed early initial carious change of enamel white spot and spend 10 sessions of therapy; when visually defined white spot enamel amperage in the lesion 6,00-7,99 MCA and the presence of a fluorescent glow diagnosed early initial carious changes enamel - bright white spot and spend 15 procedures of drug therapy "Radael-GABA".
SUBSTANCE: formulation of initial ingredients of the presented tooth paste for treating and preventing dento-facial inflammatory diseases involves a tissue regeneration stimulator specified in hyaluronic acid or sucralfate, or ε-acetylaminocapronic acid sodium salt, the enzymes lysozyme, papaine and hyaluronidase, as well as an abrasive ingredient, a moistening agent, hydrocolloid, a surfactant, sodium fluoride, tetrapotassium pyrophosphate, a preserving agent, a flavouring agent and water in certain amounts.
EFFECT: effective oral cleaning and removal of plaque, reduced bleeding gum and oral inflammations, faster dento-facial regeneration in the inflammations.
4 cl, 9 tbl, 3 ex
SUBSTANCE: formulation for the prevention of dental and parodontal diseases comprises inula rhizome and root tea, sodium benzoate, sorbitol, a flavour and water in the following proportions, wt %: inula rhizome and root tea 0.3-20.0; sodium benzoate 0.1-0.3; sorbitol 14.0-35.0; flavour 0.3-2.0; water - the rest. The formulation can be used for a wide circle of patients, including in paediatric dentistry, for people suffering chronic cardiovascular diseases, and for drivers.
EFFECT: pronounced preventive and therapeutic effect, particularly anti-caries and anti-inflammatory one.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutics and represents a method of treating periodontitis by instillations of the Cholisal gel into the gingival pockets and gingival applications 2-3 times a day for 20 days; the method differs by prescribing the Calcium-vit D3C preparation 1 capsule twice a day for one month, with the therapeutic course repeated 6 months later.
EFFECT: invention provides the higher effectiveness of the method of treating periodontitis by achieving the osteotropic and immunotropic action alongside with the local bactericidal and anti-inflammatory effect.
3 ex, 3 tbl
SUBSTANCE: invention refers to medicine, namely to dentistry, and can be used for the preventing and treating infectious processes accompanying dental surgeries. That is ensured by intraoperative administration of a therapeutic antibacterial preparation of penicillin and an antibacterial preparation of the third-generation cephalosporin. The above preparation is administered daily for 3-5 postoperative days. The above preparation is administered intra- and post-operatively once a day intravenously drop by drop for 15-35 minutes in a dose of 30-55% of the recommended daily dose.
EFFECT: invention enables reducing a possibility of antibiotic dosage with complete withdrawal of repeated intra- and post-operative one-day administration of the antibiotics, with avoiding the developing early and late postoperative infectious-inflammatory complications.
3 cl, 5 ex
SUBSTANCE: invention represents a tooth paste for treating and preventing dentoalveolar inflammatory diseases with its initial formulation containing: (0.001-5.0 carbamide ozonide, 0.01-0.5 potassium dihydrophosphate, 0.01-0.5 sodium hydroxide) or (0.001-5.0 calcium pyrrolidone carboxylate, 0.001-2.0 polyethylene glycol chitosan, 0.001-0.5 proline, 0.001-0.5 lysine, 0.001-0.5 arginine) or (0.001-5.0 D-panthenol, 0.001-0.5 magnesium ascorbyl phosphate, 0.001-5.0 sodium hydrocarbonate), 0.01-5.0 lysozyme; 0.01-5.0 papain; 2.00-20.00 abrasive; 5.00-20.88 humidifying agent; 0.05-5.0 hydrocolloid; 0.10-2.00% surfactant; 0.10-0.32 sodium fluoride; 0.50-5.00 tetrapotassium pyrophosphate; 0.15-0.40 preserving agent; 0.05-1.50 flavouring agent; water - the rest.
EFFECT: invention provides normalising saliva and oral fluid pH, reducing inflammations and accelerating the regeneration processes in the dentoalveolar tissues accompanying inflammatory diseases.
4 cl, 10 tbl, 3 ex
SUBSTANCE: invention aims at treating active chronic generalised gingivitis. What is used is immobilised nimesulide in the form of 20-minute gingival applications for 3-6 days.
EFFECT: method provides higher clinical effectiveness and reduced length of treatment.
SUBSTANCE: endodontic treatment stage involving retrieval and dilation of a root canal is performed. Gluftored liquid is introduced into the root canal of the tooth. A fibre cable is placed above a tooth canal orifice, and the liquid is reflected by means of a laser light for 30-60 seconds. The root canal is dried with a paper point. Pre-shaken Gluftored suspension is introduced into the root canal. The fibre cable is placed above the tooth canal orifice, and the suspension is reflected by means of the laser light for 30-60 seconds. The root canal is dried and filled.
EFFECT: method provides higher clinical effectiveness in the patients with dental pulp and periodontal diseases by activating the course of chemical reactions in mineralising liquid and suspension, crystal obturation of dentine tubes and closing a microbial invasion propagation path into the periodont to be protected against toxins and tissue disintegration products, forming a single mineral complex of the liquid, suspension and dentine of the root canal of the tooth, photobiostimulation of periodontal microcirculation by means of low intensity laser light energy, the presence of copper ions provides the permanent bactericidal effect.
10 dwg, 1 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions relates to composition for oral cavity care and method of its application Claimed composition includes therapeutically efficient quantity of, at least, one carbonate compound, selected from
and, at least, one excipient, where composition for oral cavity care possesses antimicrobial activity and activity in prevention biofilm attachment Also claimed is method of providing favourable effects in oral cavity care, including introduction of claimed composition into oral cavity.
EFFECT: application of, at least, one of said compounds as component of composition for oral cavity care provides efficient antimicrobial activity and inhibition of biofilm formation.
4 cl, 1 tbl, 2 ex
SUBSTANCE: as a medication, arresting inflammatory phenomena immobilised tin fluoride is used. The medication represents a composition, prepared from 3 g of a polysorb powder and 100 ml of a 0.63% solution of tin fluoride. The composition is introduced in the form of applications or on turundas, providing action of the solution for 20 minutes.
EFFECT: method increases efficiency of disease treatment with reduction of its labour consumption.
3 cl, 2 ex
SUBSTANCE: method of treating periodontitis involves dental deposit removal, dental polishing, curettage of gingival pockets, functional dental grinding and photodynamic therapy with using a photosensitiser with performing a session of photodynamic therapy using 1% aqueous toluidine blue as a photosensitiser; for this purpose, a retraction cord is placed into 1% aqueous toluidine blue until immersed completely; an exposition time in the solution makes 7-10 minutes; thereafter, the retraction cord kept in 1% aqueous methylene blue is inserted onto a gum pre-isolated from saliva in the gingival pockets completely within an involved group of teeth for 5-7 min and removed then; further, the gingival pockets treated with the photosensitiser are exposed to a laser light.
EFFECT: possibility to avoid complications related to recurrent photodynamic procedures and occurred when using the gel and installation photosensitisers, enables maintaining the concentration of the drug introduced into the gingival pocket immediately, and higher effect of the photodynamic therapy on microbial flora of periodontal pocket biofilm.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to the pharmaceutical industry, particularly to a composition for treating Helicobacter pylori. The pharmaceutical composition, which contains S-allyl-L-cysteine or its pharmaceutically acceptable salt, or their solvate, or their hydrate for preparing a therapeutic agent for Helicobacter pylori in preventing or treating gastrointestinal disorders which have Helicobacter pylori as a factor making a major contribution to the progression thereof. The pharmaceutical composition for Helicobacter pylori. The nutrient composition for Helicobacter pylori. Using S-allyl-L-cysteine or their pharmaceutically acceptable salt, or their solvate, or hydrate for preparing the therapeutic agent for Helicobacter pylori. Using S-allyl-L-cysteine or their pharmaceutically acceptable salt, or their solvate, or hydrate for preparing a nutritional composition for treating Helicobacter pylori.
EFFECT: compositions are effective for Helicobacter pylori in preventing or treating the gastrointestinal disorders.
14 cl, 18 dwg, 3 tbl, 7 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutics and medicine, and concerns an injectable insulin preparation for reducing an individual's blood glucose level. The preparation contains an insulin compound, a nicotinic acid compound and arginine.
EFFECT: invention provides the fast absorption of the insulin compound, a possibility to administer the preparation closer to a meal, as well as reduces a risk of hypoglycemia following meals.
14 cl, 5 dwg, 3 tbl, 4 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to the pharmaceutical industry and medicine. What is presented is using treo-3-phenylglutamic acid dimethyl ester hydrochloride of the following structural formula: as an agent possessing cardioprotective properties under stress stimulation.
EFFECT: treo-3-phenylglutamic acid dimethyl ester hydrochloride possesses the high cardioprotective activity.
SUBSTANCE: complex of biologically active preparations containing glutamic acid, glycine, cysteine, a pectin enterosorbent, a selenium polyvitamin-polymineral complex, a calcium preparation, as well as a cod liver oil preparation rich in nonesterified fatty acids omega 3 is administered. This complex is prescribed as a course of treatment once or twice a year for 4-6 weeks daily in the doses to provide the amounts of glycine of 300 mg, cysteine - 600 mg, glutamic acid - 4 g, selenium - 100 mcg, calcium - 4 g, cod liver oil - 25 ml with 12-15% nonesterified fatty acids omega 3, pectin - 4-5 g, as well as other microelements and vitamins in the doses to fill the normal physiological needs of the body.
EFFECT: lower adverse effects of the general toxic and genotoxic action of nanosilver on the body by normalising lipid peroxidation and the morphofunctional state of the liver and spleen, a lower degree of the DNA fragmentation.
FIELD: veterinary medicine.
SUBSTANCE: agent for optimisation of the reproductive function of cows comprises fumaric, ascorbic, succinic, and citric acid, based on the dose, mg/kg live body weight: fumaric acid - 3.0-5.0; ascorbic acid - 4.5-7.5; succinic acid - 6.0-10.0; citric acid - 1.5-2.5. The agent is environmentally safe, and its effect on the body of animals is characterized by physiological ability. It activates erythropoiesis and optimizes the redox processes, stabilizes glucose values, total lipids and cholesterol within the preferred physiological standards, supports at high level indicators of components of non-enzymatic link of the antioxidant defence system (vitamins A, C, ceruloplasmin) than consistently provides the content of toxic products of lipid peroxidation (malondialdehyde) within the physiological standards and the optimal level of non-specific resistance of animals after calving.
EFFECT: agent provides optimisation of the reproductive function of cows, reducing the time of involution of genital organs of cows after calving, increasing rate of fertilization and reduction of the length of the service period.
7 tbl, 4 ex
SUBSTANCE: invention refers to medicine, namely to gastroenterology, and can be used for providing the higher clinical effectiveness in the patients suffering dyspepsia syndrome combined with overweight. The method involves measuring an anxiety level (HARS) and a depression level (HDRS) according to Hamilton rating scales, assessing nutritional status by bioimpedancemetry, a degree of manifestation of sleep disorders, measuring glucose, testing glucose tolerance, immunoreactive insulin, cholesterol, high-density lipoprotein (HDLP), triglyceride in venous blood. If the patient is observed to suffer dyslipidemia and impaired glucose tolerance or variations of immunoreactive insulin, the preparation Dibikor is administered in a dose of 500 mg a day for three months. The patient suffering dyslipidemia and both of the disorders stated above requires administering Dibikor 1000 mg a day for three months. If the patient suffers an overweight with a body weight index falling within the range of 27 to 29.9 standard units and an active cell mass (ACM) percentage of 45 to 55 per cent as shown by bioimpedancemetry, the preparation Dietressa is administered in a dose of 1 tablet 3-4 times a day for three to six months. If the patient suffers an overweight with a body weight index falling within the range of 27 to 29.9 standard units and an active cell mass (ACM) percentage of 45 to 55 per cent as shown by bioimpedancemetry, the preparation Dietressa is administered in a dose of 2 tablet 3-4 times a day for three to six months. If the patient suffers mild and moderate sleep disorders and shows an emotive type of eating behaviour combined with mild affective disorders, the anti-depressant Valdoxane in a single dose of 25 mg a day for the night for two weeks. The course of the disease is followed by the anxiety and depression levels two weeks after the beginning of the therapy, with the positive progression of the diseases, the 25mg dose of Valdoxane remains unchanged to the end of the therapeutic course for three to six months. If no progression is exhibited, the dose is to be increased to 50 mg a day, and the therapy is continued from four to eight months. If the patient suffers severe sleep disorders and shows an emotive type of eating behaviour combined with moderate affective disorders, the anti-depressant Valdoxane in a single dose of 50 mg a day for the night for two to three months.
EFFECT: in each specific case, the method enables providing faster reduction of the clinical symptoms, including body fat weight reduction and active cell mass and water normalisation, normalising circadian rhythms of the vegetative balance, as well as prolonging the remission.
3 tbl, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to pharmaceutics and concerns a solid pharmaceutical product, a solid composition applicable in methods for photodynamic diagnosing of cancer, pre-cancer and non-cancer conditions of the lower gastrointestinal system. The solid pharmaceutical composition and pharmaceutical product contain an active ingredient representing 5-aminolevulinic acid (5-ALA), or 5-ALA ester, or their pharmaceutically acceptable salts, as well as one or more triglycerides and one or more non-ionic emulsifiers and additionally one or more enteric coating. Further, the invention refers to a method for photodynamic diagnosing of cancer, pre-cancer and non-cancer conditions of the lower gastrointestinal tract, wherein the above solid pharmaceutical compositions and pharmaceutical products are applicable.
EFFECT: group of inventions provides the effective concentration of 5-ALA in the lower gastrointestinal tract, the homogenous distribution of 5-ALA, ease of use.
17 cl, 3 ex, 9 dwg
SUBSTANCE: rats are being cooled at temperature -15°C for 3 hours a day throughout 4 weeks. The cooling session is preceded by daily oral administration of the preparation molluskam 10 mg/kg of body weight.
EFFECT: method provides the tissue-protective effect on the prostate, higher adaptive capability of the prostate in the extremely low temperature environment.
4 dwg, 2 tbl,1 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to pharmaceutics and medicine, and concerns a semi-solid composition and a semi-solid pharmaceutical product applicable in photodynamic therapy (PDT) of cancer, pre-cancer and non-cancer conditions of a female reproductive system, an anus and a penis, and contain an active ingredient which represent 5-aminolevulinic acid (5-ALA) ester or its pharmaceutically acceptable salts, one or more triglycerides, one or more viscosity enhancers specified in cellulose or its derivatives, synthetic polymers, polyethylene glycols, vegetable gums, starch and starch derivatives, carrageenan, agar, gelatine, wax and waxy solid substances. Further, the invention refers to a kit for photodynamic therapy.
EFFECT: group of inventions provides stability of the composition and product at room temperature, ease of use for a patient.
19 cl, 2 dwg, 10 tbl, 5 ex
SUBSTANCE: what is described is a biodegradable haemostatic therapeutic agent for control of bleeding, which provides co-immobilising ε-aminocapronic acid 50 mg, lysozyme 5 mg in distilled water 6.5 l for 3 hours at room temperature for dialdehyde cellulose 1 g at a degree of oxidation 12%. The material is pressed out and dried to residual moisture no more than 10% in the air in darkness. After having dried, the material is milled in a fine mill to particles having a size of 20 to 50 mcm. A rate of control of bleeding is 102 seconds. A time of total resorption is 10 days.
EFFECT: agent provides a high degree of hydrolytic destruction and a good haemostatic activity.
4 cl, 2 ex
SUBSTANCE: invention is related to systems of magnetic impedance tomography. The system comprises an excitation system having several exciting coils to generate a magnetic excitation field intended to induce eddy currents in a surveyed volume, a measurement system with several measuring coils to measure the fields generated by the induced eddy currents, at that the measuring coils are placed in a volumetric (3D) geometrical assembly and a reconstruction device intended for the receipt of measurement data from the measurement system and for the reconstruction of the object imaging in the surveyed volume against the measured data. Each measuring coil covers an area and is oriented in essence transversely to the magnetic field power lines in the exciting coils, separate measuring coils cover jointly the area corresponding to the volumetric (3D) geometrical assembly, at that the exciting coils cover the area where the measuring coils are placed. The area covered by each of the separate measuring coils is oriented perpendicular to the area covered by the exciting coils.
EFFECT: usage of the invention allows improving the quality of imaging for volumetric objects.
8 cl, 2 dwg