Diagnostic technique for electrophysiological immaturity of newborn's brain
SUBSTANCE: invention refers to medicine, namely to neonatology and neurology. During a 300-second slow sleep recording, transitory patterns are recovered on the EEG: frontal sharp waves of an average duration of 0.13 seconds, spike acute waves of an average duration of 0.045 seconds, high-amplitude PTӨ-waves of an average duration of 0.1 seconds, STOP-wave patterns of an average duration of 0.1 seconds. Indices (K) are calculated for each pattern in percentage, as a relation of the number of patterns of 300 seconds multiplied by its average duration to the recording duration (300 seconds). If K of the most patterns determined is less than 1, a physiologic norm is diagnosed; K falling within the range of 1-2 shows a moderate neurophysiologic immaturity; and if K is more than 2, major disturbances of the electrobiologic brain activity are stated.
EFFECT: method enables assessing the electrobiologic brain maturity of newborns of different gestational age that is ensured by determining and considering the transitory age-related patterns in the EEG.
4 dwg, 3 ex
The invention relates to medicine, in particular for neurology and neonatology, and can be used for diagnostic electrophysiological immaturity brain of newborns.
A known method for the diagnosis of electrophysiological brain activity in infants by determining the characteristics of the transient pattern of electroencephalogram (EEG) slow vysokovoltnyh waves sawtooth form, localized in the temporal leads, registered in the fast stage of sleep. This method is determined by the duration of one pattern and the frequency of its registration in one minute recording stage REM sleep [Pear P. L., La Fleur B. J., S. Reigle C., Rich A-S. et. al. // Saw tooth wave density analysis during REM sleep in normal volunteers. // Sleep Medicine 2002; V3, 153, p255-258].
The disadvantage of this method is its low information content, since the duration of REM sleep in premature infants depends on the gestational age of the patient under examination, the number of transitive patterns in stage REM sleep significantly less than in the stage of slow wave sleep. In addition, the definition of only one transient pattern does not fully reflect the physiological immaturity of the brain. Another disadvantage of this method is that it defines the pattern rarely occurs in newborn EEG.
There is a method of determining characteristics the specifications specifications total spontaneous brain activity in infants by analyzing the frequencies and shapes of the main EEG rhythms in the stage of slow wave sleep (alpha, beta, theta and Delta rhythms) [Tolonen M, PalvaJ. M., Andersson, S., Vanhatalo S. // Development of the spontaneous activity transients and ongoing cortical activity in human preterm babies. // Neuroscience 2007;30;145(3):991-1006].
The disadvantage of this method is the lack of a definition of those transient EEG patterns, newborns, which reflect the degree of neurophysiological immaturity.
Closest to the claimed is a method of determining characteristics of the transient pattern of EEG acute frontal waves recorded during stage REM sleep. The method is quantitative counting only one, but frequent in newborns pattern (acute frontal waves) EEG for the entire duration of REM sleep [Ana Chrystina Crippa, Carlos Eduardo Sivado, Luciano de Paola, Rosana H. Scolaetal.// Analysis of Frontal Sharp Transients in 32 Neonatal Polysomnography in Healthy Fullterm Newborns.// Arq Neuropsiquiatr 2007;65(2-A):222-227].
The disadvantage of this method, selected as a prototype, is that the definition of transient pattern is carried out in stage REM sleep, the duration of which depends on the gestational age of the newborn child. In addition, it is known that the number of transitive patterns in stage REM sleep in normal less than in the stage of slow wave sleep, therefore, the probability of reception of transient patterns in the stage of slow wave sleep higher than in fast.
Another disadvantage of the prototype is that opredelyaytes the characteristics only of individual EEG patterns, that makes it difficult to determine the physiological maturity and thus reduces the diagnostic capability of the method.
The present invention is the advanced diagnostic capabilities of the method.
The technical result of the invention is achieved in that in the method for the diagnosis of electrophysiological immaturity brain of newborns using quantitative characteristics of transient age-dependent patterns, namely, that calculate transient pattern in the write period of sleep for a certain period of epoch EEG, within 300 seconds of recording slow wave sleep distinguish transitory patterns: frontal sharp waves average duration of 0.13 seconds, spike-sharp waves average duration of 0.045 seconds, high-amplitude PTΘ-wave average duration of 0.1 second, the pattern of STOP-wave average duration of 0.1 seconds; determine the index (K) for each selected transient pattern EEG premature baby by the formula:
where N is the number of the designated pattern for 300 seconds;
Y - the average duration of the defined pattern;
τ is the duration of a recording, equal to 300 seconds
and when the value To most defined transient patterns of less than 1 diagnose the physiological norm, when Velicina most defined transient patterns in the interval 1-2 diagnosed with moderate neuro-physiological immaturity, and when the value To most defined transient patterns more than 2 diagnose gross violations of electrobiological activity of the brain.
The choice of time period for determining the indices of transient patterns equal to 300 seconds, due to the relatively short duration of the stage of slow wave sleep in newborn infants (duration is on average about 10 minutes), rapid change her stage REM sleep, which comes the awakening of the patient. The duration of EEG recordings in 300 seconds is sufficient for the registration of transient patterns and fully reflects the characteristics of electrobiological activity of the brain of the patient. Therefore, improving the efficiency of the diagnosis.
Another distinctive feature of the proposed method is the measurement of transient EEG patterns, that allows you to create a quantitative description of each transient EEG pattern and to estimate the percentage of this pattern of EEG recordings, which reflects the degree of the physiological immaturity of the brain.
The method is as follows. The analysis of all transient EEG patterns.
Known average duration of each defined pattern of EEG recordings:
- average length of frontal sharp waves is 0.13 seconds;
- average permanent the ability spike and sharp waves is 0.045 seconds;
- the average duration RT-wave is 0.1 seconds;
- the average duration of the STOP-waves is 0.1 seconds.
Knowledge of the average duration of each transient pattern allows you to make calculations and to determine the percentage of this pattern in the EEG recordings.
In Fig.1 presents a plot of EEG recordings newborn registration frontal sharp waves.
In Fig.2 presents a plot of EEG recordings newborn registration pattern STOP (in the left occipital derivations).
In Fig.3 presents a plot of EEG recordings newborn registration pattern of the complex Delta-brushes, clearly defined in the right occipital leads and registration of multiple sporadic patterns of adhesions sharp waves.
In Fig.4 presents a plot of EEG recordings newborn registration pattern of high-amplitude RC in the temporal leads right hemisphere.
A study carried out in a period of slow sleep of a newborn is subject to mandatory standard conditions of EEG recordings, including: standard speed resolution / size of 30 mm/sec; sensitivity channels - 10 µv; recording time 60 minutes; recording be performed without the use of filters; the age of the subject in a premature infant to adjust with age, full-term newborn is 38-42 weeks. Check with the standing dream, wakefulness is carried out according to two criteria: surveillance for rapid movement of the eyeballs and the determination of changes in EEG activity in the form of high-amplitude slow waves.
For registration of EEG in the examined newborns should use a 13-electrode system, checkoway electrodes, mounted in a plastic frame. Use the international system of electrode placement in the neonatal modification (10-20) with the use of video monitoring of the patient and the use of mono - and bipolar leads. Indexes transient patterns determine the time interval of 300 seconds of EEG recordings in the stage of slow wave sleep.
Example 1. Patient B. (history No. 23740, D. R. 19.11.10) - premature girl, gestational age 34 weeks, he entered the Department of ORIT newborn SPb GPA on the 2nd day of life.
Diagnosis to conduct EEG research: hypoxic-ischemic brain damage in the first degree, early recovery period, the outer substitution hydrocephalus, demyelinization, motor disorders. In post-conceptual age 38 weeks performed EEG with video and the implementation of the method for the diagnosis of electrophysiologically immaturity brain of newborns using quantitative characteristics of transient age-dependent patterns and op is adelene their index in the period, equal to 300 seconds of EEG recordings in the stage of slow wave sleep.
The results of EEG studies:
During wakefulness is logged continuous activity, is dominated by Delta activity with a frequency of 2-3 Hz and amplitude up to 60 µv, theta activity in the form of groups of waves with a frequency of 4-5 Hz and amplitude up to 55 mV.
During slow sleep is logged dashed curve (tracealternant). Perspicacia intervals of depression rhythm is about 6 seconds. Interhemispheric synchronic is 85%.
Indexes transient patterns are: frontal sharp waves and 1.7%; RT - 2%; STOP - 1,66%, spike-waves - of 0.48%.
Conclusion according to the results of EEG: changes in the bioelectrical activity of the brain, moderate neuro-physiological immaturity (given that the values of the indexes of most transient patterns were in the range of 1-2 values).
The final diagnosis using EEG results: hypoxic-ischemic brain damage in the first degree, early recovery period, the outer substitution hydrocephalus, demyelinization, reasonable neurophysiological immaturity, motor disorders, the risk of developing moderate delay of psychomotor development.
Example 2. Patient L. (history No. 1230, D. R. 26.11.10) - a premature boy, gestational age 28/29 weeks, he entered the Department of ORI the newborn SPb GPA on the 3rd day of life.
Diagnosis to conduct EEG research: hypoxic-ischemic brain damage is severe, early recovery period, mixed substitution hydrocephalus, periventricular leucomalacia (stage cysts), hypoplasia of the corpus callosum, demyelinization, motor disorders (spastic tetraparesis), symptomatic epilepsy.
In post-conceptual age 40 weeks performed EEG with video recording and analysis the EEG results from the implementation of the method for the diagnosis of electrophysiologically immaturity brain of newborns using quantitative characteristics of transient age-dependent patterns and determine their index in the time interval of 300 seconds of EEG recordings in the stage of slow wave sleep.
The results of EEG studies:
During wakefulness is logged continuous activity, is dominated by Delta activity with a frequency of 3 Hz and amplitude up to 60 µv, theta activity in the form of groups of waves with a frequency of 4-5 Hz and amplitude up to 40 µv, irregular. Epileptiform activity is not logged.
During slow sleep is logged pattern dashed curve (tracealternant). Perspicacia intervals of depression rhythm is about 5 seconds. Interhemispheric synchronic outbreaks is 80%.
Indexes transient patterns accounted for the pose: frontal sharp waves - 2,38%; Θ - 2,33%; STOP - 8,66%, spike-waves - of 1.23%.
Conclusion according to the results of the EEG: a gross violation electrobiological activity of the brain, severe neuro-physiological immaturity (most index transient patterns exceeded the value of 2).
The final diagnosis using EEG results: hypoxic-ischemic brain damage is severe, early recovery period, mixed substitution hydrocephalus, periventricular leucomalacia (stage cysts), hypoplasia of the corpus callosum, demyelinization, motor disorders (spastic tetraparesis), symptomatic epilepsy, severe neuro-physiological immaturity, the risk of formation of a coarse delay of psychomotor development.
Example 3. Patient A. (history No. 2739, D. R. 28.04.11) - premature girl, gestational age of 35 weeks, he entered the Department of ORIT newborn SPb GPA on the 4th day of life.
Diagnosis to conduct EEG research: post-hypoxic brain damage is mild, early recovery period, external hydrocephalus in substitution type, motor disorders of mild severity. In post-conceptual age 38/39 weeks performed EEG with video recording and analysis the EEG results from the implementation of the method for the diagnosis of power is ideologicheskoi immaturity brain of newborns using quantitative characteristics of transient age-dependent patterns and determine their index in the period, equal to 300 seconds of EEG recordings in the stage of slow wave sleep.
The results of EEG studies:
During wakefulness is logged continuous activity, is dominated by Delta activity with a frequency of 3-4 Hz and amplitude up to 40 µv, theta activity in the form of groups of waves with a frequency of 4-5 Hz and amplitude up to 40 µv, fairly regular. Epileptiform activity is not logged.
During slow sleep is logged pattern dashed curve (trace alternant). Perspicacia intervals of depression rhythm is 3-5 seconds. Interhemispheric synchronic outbreaks is 80%.
Indexes transient patterns are: frontal sharp waves - 1,03%; RT - 1%; STOP - 0,66%, spike-waves - 0,76%.
Conclusion according to the results of EEG: neurophysiological maturity corresponds to the age norm (index values of most transient patterns within the unit).
The final diagnosis using EEG results: post-hypoxic brain damage is mild, early recovery period, external hydrocephalus in substitution type, motor disorders of mild severity, neurophysiological maturity corresponds to the post-conceptual age.
The proposed method allows for a universal approach to the quantitative assessment of the characteristics of all transient patterns of e is G a stage of slow wave sleep, that gives the opportunity to assess the degree of maturity electrobiological maturing brain of newborns of different gestational age to assess the degree and level of functional changes in the Central nervous system, which, in turn, gives the possibility to predict the likely neurological complications caused by immaturity of the child and related to the immaturity of pathological conditions of the Central nervous system, and external adverse factors.
This method allows you to identify possible cerebral disorders and to develop new approaches in the treatment of brain pathology in newborns of different gestational age. In addition, the inventive method allows to assess the adaptive capacity of the brain of a newborn child when his damage in terms of practical medicine.
Method for the diagnosis of electrophysiological immaturity brain of newborns using quantitative characteristics of transient age-awesime patterns, namely, that calculate transient pattern in the write period of sleep for a certain period of epoch EEG, characterized in that during the 300 seconds of recording slow wave sleep distinguish transitory patterns: frontal sharp waves average long is inetu of 0.13 seconds
spike-sharp waves average duration of 0.045 seconds, high-amplitude RC-wave average duration of 0.1 second, the pattern of STOP waves average duration of 0.1 seconds; determine the index (K) for each selected transient pattern of EEG premature baby by the formula:
N is the number of the designated pattern for 300 seconds;
Y - the average duration of the defined pattern;
τ is the duration of a recording, equal to 300 seconds,
and when the value To most defined transient patterns of less than 1 diagnose the physiological norm, when the value To most defined transient patterns in the interval 1-2 diagnosed with moderate neuro-physiological immaturity, and when the value To most defined transient patterns more than 2 diagnose gross violations of electrobiological activity of the brain.
SUBSTANCE: invention refers to medicine, namely to psychiatrics. In addition to the clinical study, an electroencephalography coherence analysis is conducted within the range of 30-45 Hz before psychotropic agents are prescribed. That is followed by determining middle zonal indices of the left and right hemispheres calculated between the midtemporal and following cortical regions: frontal, central, parietal, occipital, anteriofrontal and posteriofrontal in the homolateral direction. A hemispheric asymmetry factor (HAF) is calculated by dividing the middle zonal index of the left hemisphere by the middle zonal index of the right hemisphere. If the HAF value is less than 1, paranoid schizophrenia is diagnosed; and the value more than 1 shows schizo-affective disorder.
EFFECT: technique enables providing the more reliable differential diagnostics that is ensured by determining the zonal indices of the right and left hemispheres to calculate the hemispheric asymmetry factor.
SUBSTANCE: invention refers to medicine, namely to psychiatrics. A clinical examination is combined with recording an electroencephalogram (EEG); its spectral and coherent analyses are carried out. The following values are determined: T6-AA-lead power spectrum within the range of 3.5-5 Hz, F7-AA-lead power spectrum within the range of 2-3 Hz, T5-AA -lead power spectrum within the range of 23-24.5 Hz, hemispheric power asymmetry between F8-AA and F7-AA-leads within the range of 24.5-26 Hz, P4-C4-lead coherence within the range of 8-13 Hz, T4-F8 within the range of 23-24.5 Hz, T3-F7-lead power spectrum within the range of 26-27.5 Hz, T5-O1 within the range of 17-18.5 Hz, T3-F8 within the range of 20-21.5 Hz. Logarithms of the derived values are calculated. An integral diagnostic value is determined by mathematical formula taking into account the calculated logarithm and coefficient-corrective values. If the integral diagnostic value appears to be positive, a recurrent depressive disorder is diagnosed, while a bipolar affective disorder is shown by the negative integral diagnostic value.
EFFECT: method enables providing higher diagnostic reliability at the early stages of the disease that is ensured by the optimum selection of the values, and the mathematical calculation of the integral value.
SUBSTANCE: invention refers to medicine, labour safety, vocational selection of rescue workers. The invention can be used for vocational selection in the sectors of industry using personal protective equipment, as well as for the workers labour safety in the sectors of industry with harmful working conditions. The method involves vocational selection and duty control on the basis of electroencephalogram (EEG) values and cardiological findings. The examination is performed prior to and when using the personal protective equipment. The cardiological examination involves assessing the heart rate variability with using the amplitude-frequency spectrum Fourier analysis VLF at a vibration frequency within the range of 0.0033-0.04 Hz, LF - at a frequency of 0.05-0.15 Hz and HF - at a frequency of 0.16-0.80 Hz, and is five-staged: initial resting state, mental work load, recovery of mental work load, hyperventilation load, recovery of hyperventilation load. At the beginning, the heart rate variations and EEG are examined prior to using the personal protective equipment. If any of the five stages of the heart rate variation examination shows the pulse more than 90 beats per minute, as well as changes from the normal values of: approximating entropy - less than 180, LF - less than 6 point, an alpha wave amplitude - to 12 vibrations per second and the presence of the paroxysmal activity by EEG, the prevailing sympathetic nervous system is stated, or if any stage of the heart rate variation examination shows the pulse less than 60 beats per minute, as well as changes from the normal values of: blood pressure - more than 140/90 mmHg, VLF - more than 130 points, HF - more than 16 points, an alpha wave amplitude - less than 25 mcV, the prevailing parasympathetic nervous system is stated; a low level of adaptation to the personal protective equipment is predicted, and a rescue work is not recommended during the vocational selection; the examination is terminated. If the heart rate variation and EEG prior to using the personal protective equipment fall within the normal values, the heart rate variation when using the personal protective equipment is started with the patient examined when using the personal protective equipment and performing a cycle ergometer test, and recording the hyperadaptotic changes of the assessed values: VLF - more than 130 points in relation to the normal value when using the personal protective equipment and LF and HF vibrations; an incomplete or unfinished adaptation to the personal protective equipment, and the rescue worker is suspended from work for several hours; if VLF is more than 130 points recorded 10-15 min after activating the personal protective equipment, a good adaptation level to the personal protective equipment is predicted.
EFFECT: method enables assessing the vegetative nervous function and predicting the rescue workers' adaptation level to the personal protective equipment.
11 tbl, 5 ex
SUBSTANCE: patient is trained by challenging to imagine a paretic limb movement and controlling the imagined movement. An electroencephalography is recorded; the recorded data are transferred to a computer for synchronous processing, and arousal reaction signals of a sensorimotor rate responsible for the imagined movement are isolated by means of an EEG pattern classifier according to the Bayes method. Identification results of the mental challenge are presented to the patient by a visual feedback in the form of a mark on a monitor. The mark re-position testifies to accuracy of the challenge. The imagined movement challenge is presented for 10 seconds. The training course makes 6-12 days, one training a day, of the length of 20-30 minutes every 1 to 4 days.
EFFECT: method provides more effective rehabilitation that is ensured by the feedback training in the conditions enabling the patient controlling the imagined paretic limb movement visually.
3 dwg, 4 tbl, 2 ex
SUBSTANCE: method includes rendering an image which creates a depth and volume effect (IDE); detecting electrical activity (EEG) of the brain for white sheet (IWS) rendering and for image IDE rendering; calculating the sum of the overall coherence amplitude on all derivations and components of EEG rhythms, first for IWS rendering
EFFECT: method enables to obtain an objective evaluation of the capability for three-dimensional sensing of flat images, which is achieved owing to use of coherent EEG analysis.
SUBSTANCE: invention refers to medicine, and may be used in occupational pathology. Person's open eyes are exposed to a white light of a colour temperature varying within the range of 1700 K - 10000 K. An electroencephalogram is recorded; its spectral analysis is performed to state the effect to be activating as shown by a power spectrum of alpha and theta waves reducing by more than 25% of background values.
EFFECT: method enables an individual selection of a colour temperature having the activating effect.
2 tbl, 2 ex
SUBSTANCE: invention refers to medicine and may be used for assessing the light exposure generated by a light-emitting-diode source on the functional status of human brain cortex. The white light exposure covers individual's open eyes at colour temperature 1700-10000 °K, illumination 80-300 lx at the eye level. That is followed by electroencephalogram recording and spectral analysis. If observing an increase or a decrease of alpha or teta wave spectral power by more than 25% of a baseline value, the light exposure is considered to be physiologically active, and by less than 25% - as physiologically neutral.
EFFECT: method provides more reliable assessment of the functional status of human brain that is ensured by biological activity rating within the alpha and teta wave range.
4 tbl, 4 ex
SUBSTANCE: invention refers to medicine, and may be used for changing the functional status of an individual. The individual's open eyes are exposed to white light at colour temperature 1700 °K or 10000 °K, at lighting intensity 200 lx at the eye level. That is followed by electroencephalogram recording and spectral analysis. If an alpha wave spectral power increases by more than 50%, while a teta wave spectral power increases by more than 25% of a baseline value, the effect is considered to be relaxant.
EFFECT: method enables assessing the action of colour temperature individually that can cause the relaxant effect on an individual.
2 tbl, 2 ex
SUBSTANCE: invention refers to medicine, namely dentistry. An encephalogram (EEG) is recorded in patients with the disturbed cerebral hemodynamics. The EEG is repeated with an occlusal load using 10-20 g of comb honey for 3-4 minutes. If a post-therapeutic alpha rhythm recovers or prevails on the EEG, the conducted orthopaedic alignment is considered to be effective.
EFFECT: method provides more reliable estimation of the orthopaedic alignment of dental patients suffering a cerebrovascular pathology that is ensured by using the occlusal load.
4 dwg, 1 ex
SUBSTANCE: invention refers to medicine and may be used to estimate the indications for prescribing drug preparations incompatible with alcohol ingestion, in addictology, psychiatry, as well as psychotherapy. There are performed electroencephalography and psychological testing: the first stage involves electroencephalography (EEG) in the patients diagnosed with alcohol dependence syndrome for the presence of short wave, desynchronosis and asymmetric bioelectric brain activity, disturbed alpha activity; the given study aims at finding the presence or absence of an organic pathology of brain functioning related to disturbed bioelectric activity. At the second stage, the patients with EEG findings showing no signs of an organic brain involvement are estimated considering the personal nonverbal emotional attitude system using colour repertory grid (CRG) techniques with using groups of alcohol-related objects and displaying Luscher colour cards. Pearson linear correlation coefficients of the elements and constructs to be further processed using a principal component analysis procedure. The detected factor loadings of the two most important components are used as two-dimensional element coordinates when constructing a graphical model of the attitude system of the person being tested. The presence of high conformity in the two representational personal emotional attitude system (verbal and nonverbal) gives evidence of the intact and adequate personality motivation sphere and serves as an indication for prescribing drug preparations of opioid receptor antagonists (naltrexone) and a cognitive behaviour therapy of alcohol dependency. The presence of low conformity is a sign of such disturbances of the motivation sphere that neutralise possibilities of psychotherapeutic methods and serves as a proof for prescribing drug preparations incompatible with alcohol ingestion (disulphiram, cyanamide).
EFFECT: method enables the objective and accurate estimation of the correctness of indications in predicting the effective use of drug preparations incompatible with alcohol ingestion, within the alcohol dependence therapy.
FIELD: medicine, neurology, psychopathology, neurosurgery, neurophysiology, experimental neurobiology.
SUBSTANCE: one should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another.
EFFECT: higher accuracy of diagnostics.
5 dwg, 1 ex, 1 tbl
FIELD: medicine, neurology.
SUBSTANCE: one should establish neurological status, bioelectric cerebral activity, availability of perinatal and ORL pathology in patients, establish their gradations and numerical values followed by calculation of prognostic coefficients F1 and F2 by the following formulas: F1=-31,42+1,49·a1-2,44·a2+0,2·а3+1,63·a4+0,62·а5+3,75·a6+1,8·а7-3,23·a8-0,8·а9-1,32·а10+3,26·а11+8,92·a12-2,0·a13+3,88·а14+1,79·a15+0,83·a16-2,78·a17; F2=-27,58+1,43·a1+3,31·а2+0,08·а3+3,05·а4-0,27·а5+2,69·а6+3,11·а7-6,47·a8-6,55·a9+1,99·а10+5,25·а11+7,07·a12-0,47·a13+0,13·a14+4,04·a15-1,0·a16-1,14·а17, correspondingly, where a1 - patient's age, a2 - studying either at the hospital or polyclinic, a3 - duration of stationary treatment (in days), a4 - unconscious period, a5 - terms of hospitalization since the moment of light close craniocerebral trauma, a6 - smoking, a7 - alcohol misuse, a8 - arterial hypertension, a9 - amnesia, a10 - close craniocerebral trauma in anamnesis, a11 - psychoemotional tension, a12 - meteolability, a13 - cervical osteochondrosis, a14 - ORL pathology, a15 - availability of perinatal trauma in anamnesis with pronounced hypertension-hydrocephalic syndrome, a16 - availability of paroxysmal activity, a17 - availability and manifestation value of dysfunction of diencephalic structures. At F1 ≥ F2 on should predict the development of remote aftereffects in young people due to evaluating premorbid background of a patients at the moment of trauma.
EFFECT: higher reliability of prediction.
2 ex, 1 tbl
FIELD: medicine; medical engineering.
SUBSTANCE: method involves doing multi-channel recording of electroencephalogram and carrying out functional tests. Recording and storing rheoencephalograms is carried out additionally with multi-channel recording of electroencephalogram synchronously and in real time mode in carotid and vertebral arteries. Electroencephalograms and rheoencephalograms are visualized in single window with single time axis. Functional brain state is evaluated from synchronous changes of electroencephalograms, rheoencephalograms and electrocardiograms in response to functional test. The device has electrode unit 1 for recording bioelectric brain activity signals, electrode unit 2 for recording electric cardiac activity signals, current and potential electrode unit 3 for recording rheosignals, leads commutator 4, current rheosignal oscillator 5, synchronous rheosignal detector 6, multi-channel bioelectric brain activity signals amplifier 7, electrophysiological signal amplifier 8, demultiplexer 9, multi-channel rheosignal amplifier 10, multi-channel analog-to-digital converter 11, micro-computer 12 having galvanically isolated input/output port and personal computer 13 of standard configuration.
EFFECT: enhanced effectiveness of differential diagnosis-making.
11 cl, 6 dwg
FIELD: medicine; medical engineering.
SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.
EFFECT: wide range of functional applications.
15 cl, 10 dwg
FIELD: medicine, psychiatry.
SUBSTANCE: one should conduct EEG-testing to detect total value of the indices of spectral power or percentage spectral power of delta- and teta-rhythms due to spectrometric technique in frontal, parietal, central and temporal areas both before and during emotional-negative loading when visual emotionally negative stimuli are presented followed by their imaginary reproduction. In case of higher indices to visual stimuli being above 15% against the background one should diagnose epilepsy. The method enables to increase the number of diagnostic means, increase accuracy and objectivity in predicting epilepsy with polymorphic paroxysms at dissociation of clinical and EEG-values.
EFFECT: higher efficiency of diagnostics.
1 ex, 1 tbl
FIELD: medicine, neurophysiology.
SUBSTANCE: one should carry out EEG survey to detect spectrometrically the index of full range if alpha-rhythm both before and after therapy. Moreover, power index of full range of alpha-rhythm and the index of 9-10 Hz-strip's spectral power should be detected in occipital cerebral areas. One should calculate the value of the ratio of the index of 9-10 Hz-strip's spectral power to the index of full range of alpha-rhythm and at the increase of this value by 20% against the background it is possible to evaluate positive result of therapy. The method increases the number of diagnostic means applied in evaluating therapeutic efficiency in the field of neurophysiology.
EFFECT: higher efficiency of evaluation.
FIELD: medicine, neurology.
SUBSTANCE: method involves carrying out the standard vascular and nootropic therapy. Diazepam is administrated under EEG control with the infusion rate that is calculated by the following formula: y = 0.0015x - 0.025 wherein y is the rate of diazepam administration, mg/h; x is an average EEG amplitude, mcV. Method provides enhancing the effectiveness of treatment of patients. Invention can be used for treatment of patients in critical severe period of ischemic insult.
EFFECT: enhanced effectiveness of treatment.
2 tbl, 1 dwg, 1 ex
SUBSTANCE: method involves selecting signals showing patient consciousness level and following evoked auditory potentials as responses to repeating acoustic stimuli, applying autoregression model with exogenous input signal and calculating AAI index showing anesthesia depth next to it.
EFFECT: quick tracing of unconscious to conscious state and vice versa; high accuracy of measurements.
9 cl, 3 dwg
FIELD: medicine; experimental and medicinal physiology.
SUBSTANCE: device can be used for controlling changes in functional condition of central nervous system. Device has receiving electrodes, unit for reading electroencephalograms out, analog-to-digital converter and inductor. Low noise amplifier, narrow band filter linear array which can be program-tuned, sample and store unit, online memory, microcontroller provided with controlled permanent storage, liquid-crystal indicator provided with external control unit are introduced into device additionally. Receiving electrodes are fastened to top part of patient's head. Outputs of electrodes are connected with narrow band filters linear array through electroencephalograph. Output of linear array is connected with input of input unit which has output connected with input of analog-to-digital converter. First bus of analog-to-digital converter is connected with online storage. Recording/reading bus of microcontroller is connected with control input of input unit and its starting bus is connected with address input of online storage. Third control bus is connected with narrow band filters linear array. Second control bus is connected with liquid-crystal indicator. Output bus is connected with inductor. External control (keyboard) of first control bus is connected with microcontroller. Output of online storage is connected with data input of microcontroller through 12-digit second data bus. Efficiency of influence is improved due to getting specific directed influence being based onto general technological transparency of processing of human brain's signals and strictly specific influence based on the condition of better stimulation.
EFFECT: increased efficiency.
3 cl, 1 dwg, 1 tbl
FIELD: medicine, neurology, professional pathology.
SUBSTANCE: one should carry out either biochemical blood testing and electroencephalography or SMIL test, or ultrasound dopplerography of the main cranial arteries, rheoencephalography (REG) to detect the volume of cerebral circulation and hypercapnic loading and their digital values. Then it is necessary to calculate diagnostic coefficients F by the following formulas: Fb/e=6.3-0.16·a1+0.12·a2-1·a3+0.2·a4, or FSMIL=9.6+0.16·a5-0.11·a6-0.14·a7+0.07·a8, or Fhem=48.6-0.04·a9+0.15·a10+13.7·a11-0.02·a12+24.7·a13, where Fb/e -diagnostic coefficient for biochemical blood testings and EEG; FSMIL - diagnostic coefficient for SMIL test; Fhem - diagnostic coefficient for hemodynamic testing; 6.3; 9.6 and 48.6 - constants; a1 - the level of vitamin C in blood; a2 - δ-index by EEG; a3 - atherogenicity index; a4 - the level of α-proteides in blood; a5 - scale 3 value by SMIL; a6 - scale K value by SMIL; a7 - scale 5 value by SMIL; a8 - scale 7 value by SMIL; a9 - the level of volumetric cerebral circulation; a10 - the value of linear circulatory rate along total carotid artery, a11 - the value of resistive index along total carotid artery; a12 - the value for the tonicity of cerebral vessels at carrying out hypercapnic sampling by REG; a13 - the value for the intensity of cerebral circulation in frontal-mastoid deviation by REG. At F value being above the constant one should diagnose toxic encephalopathy, at F value being below the constant - discirculatory encephalopathy due to applying informative values.
EFFECT: higher accuracy of diagnostics.
6 ex, 1 tbl