Differential diagnostic technique for paranoid schizophrenia and schizo-affective disorder
SUBSTANCE: invention refers to medicine, namely to psychiatrics. In addition to the clinical study, an electroencephalography coherence analysis is conducted within the range of 30-45 Hz before psychotropic agents are prescribed. That is followed by determining middle zonal indices of the left and right hemispheres calculated between the midtemporal and following cortical regions: frontal, central, parietal, occipital, anteriofrontal and posteriofrontal in the homolateral direction. A hemispheric asymmetry factor (HAF) is calculated by dividing the middle zonal index of the left hemisphere by the middle zonal index of the right hemisphere. If the HAF value is less than 1, paranoid schizophrenia is diagnosed; and the value more than 1 shows schizo-affective disorder.
EFFECT: technique enables providing the more reliable differential diagnostics that is ensured by determining the zonal indices of the right and left hemispheres to calculate the hemispheric asymmetry factor.
The invention relates to medicine, namely to psychiatry, and for neurophysiology.
The problem of differential diagnosis of paranoid schizophrenia and schizoaffective disorder is relevant especially when the first episodes of the disease due to the complexity of the clinical picture that has implications for the selection of adequate therapy.
A known method for the diagnosis of paranoid schizophrenia and schizoaffective disorder by conducting clinical studies (In kN.: Guide to psychiatry. Edited Tiganov. Moscow, 1999. S. 407-666). The disadvantage of this method is the subjectivity of the assessment, depending on the qualification of the doctor.
There is a method of investigation of various forms of schizophrenia using spectral and coherence analysis of the EEG in the range of 30-45 Hz until the appointment of psychotropic drugs (Iznik A. F. Neurophysiology of schizophrenia. Guide to psychiatry. Edited Tiganov A. C. M., 1999. So 1. S. 503-504; Melnikova I. S., Lapin I. A., Sargsyan Century Century an overview of the use of a coherence analysis of EEG in psychiatry. Social and clinical psychiatry. 2009. So 19. No. 1. C. 90-94; Sagittarius Century B., Novototsky-Vlasov, C. Y., Golikova J. C. Cortical communication in schizophrenic patients with positive and negative symptoms. Journal of higher nervous activity. 2001. So 51, No. 4. S. 452-460). The disadvantage of this method is harmless to the high accuracy and the inability differential diagnosis of these diseases.
The technical result of the proposed solution is to expand the range of diagnostic methods, improving the accuracy and objectivity in diagnosis, especially during the initial admission that promotes proper selection of adequate therapy depending on the results of the study.
This result is achieved in that, in addition to a clinical study conducted EEG coherence analysis in the range of 30-45 Hz to destination psychotropic substances, determine the average zonal indices of the left and right hemisphere, calculated between sredniowiecznymi and the following cortical areas: frontal, Central, parietal, occipital, prednisonum and zadnevisochnoy homolateral, calculate the coefficient of interhemispheric asymmetry (KMA) by dividing the average of the zonal index of the left hemisphere on average zonal index of the right hemisphere and at KMA less than 1 diagnosed with paranoid schizophrenia, a value of more than 1 schizoaffective disorder.
Does not follow from the prior art is the fact that the value of KMA, calculated by dividing the average of the zonal index of the left hemisphere, on the average zonal index of the right hemisphere can serve as an objective criterion for the differential diagnosis of paranoid form of schizophrenia and schizoaffective disorders is.
The method is as follows.
Patient with a diagnosis of paranoid schizophrenia or schizoaffective disorder in addition to conduct clinical EEG study by a standard method using a coherent analysis of the electroencephalogram in the range of 30-45 Hz to destination psychotropic drugs (In kN.: "Clinical electroencephalography". Edited Rusinova C. S. Ed. "Medicine", M, 1973, S. 19-29). Determine the average zonal indices of the left and right hemispheres, calculated between sredniowiecznymi and the following cortical areas: frontal, Central, parietal, occipital, prednisonum and zadnevisochnoy homolateral, calculate the coefficient of interhemispheric asymmetry (KMA) by dividing the average of the zonal index of the left hemisphere on average zonal index of the right hemisphere and at KMA less than 1 diagnosed with paranoid schizophrenia, a value of more than 1 schizoaffective disorder.
Example 1. Patient K., 1963 R. History No. 584. Was admitted to the Department of the fgbi "Moscow research Institute of psychiatry of the Ministry (MNIIP) 28 March 2008. Diagnosis: Schizophrenia, paranoid form (F20.0).
Mentally ill since 2005, when there was a hearing true hallucinations, followed by pseudohallucinations commenting, then peremptory character, soprovozhdayas the ideational, motor and sensory automatisms. Expressed delusional ideas of persecution and impact. Yourself asked for help in Advisory Department MNIIP. Arrived for treatment in the clinic of the first psychotic episode.
After clinical studies prior to the appointment of psychotropic therapy, the patient was conducted EEG study, followed by coherent analysis of the EEG in the range of 30-45 Hz standard. Indicators of coherence in the left hemisphere was: between srednespisochnoe and frontal cortical area and 0.35 Hz, between srednespisochnoe and Central cortical area - 0,49 Hz, between srednespisochnoe and parietal cortical area - 0,57 between srednespisochnoe and occipital cortical area - 0,49 between srednespisochnoe and prednisone cortical area is 0.65, between srednespisochnoe and significanoe cortical area is 0.55. Average zonal index of the left hemisphere was(0,35+0,49+0,57+0,49+0,65+0,55)=3,1; 3,1:6=0,52.
Indicators of coherence in the right hemisphere: between srednespisochnoe and frontal cortical area was 0.39 Hz, between srednespisochnoe and Central cortical area of 0.53 Hz, between srednespisochnoe and parietal cortical area to 0.69 between srednespisochnoe and occipital cortical area is 0.55, between srednespisochnoe and prednisone cortical area - 0.76mm, between srednespisochnoe and significanoe cortical area is 0.67. The middle zone is the index of the right hemisphere was(0,39+0,53+0,69+0,55+0,76+0,67)=3,59; 3,59/6=0,59.
The coefficient of interhemispheric asymmetry (KMA) was 0.52 in/0,59=0,88 (less than 1).
Thus, the data obtained KMA less than 1 correspond to the diagnosis of schizophrenia, paranoid form, which coincides with the clinical diagnosis.
The patient is assigned Rispolept to 6 mg per day. Two weeks later the patient's condition has improved, delusions of influence and persecution was desacralization disappeared hearing pseudohallucinations. Criticism to the partial state. Discharged with recommendations supporting neuroleptic therapy. After discharge takes medicine continues to work, circle of friends and interests narrowed.
Example 2. Patient D., 1980, R. History No. 1056. Was admitted to the Department MNIIP 24.06. 2008. Diagnosis: Schizoaffective disorder (F 25).
Mentally ill since August 2007, when amid prolonged insomnia, anxiety, decreased mood appeared delusional ideas of relationships and the pursuit of sensual nature. It was noted depersonalization and derealization, symptom internetnorpace and "double". At the urging of relatives appealed to the Advisory Department MNIIP. Arrived for treatment in the clinic of the first psychotic episode.
After clinical studies prior to the appointment of psychotropic therapy, the patient was conducted EEG study, followed by coherent analysis of the range of 30-45 Hz standard. Indicators of coherence in the left hemisphere was: between srednespisochnoe and frontal cortical area - 0,29 Hz, between srednespisochnoe and Central cortical area is 0.37 Hz, between srednespisochnoe and parietal cortical area - 0,31 between srednespisochnoe and occipital cortical area - 0,26 between srednespisochnoe and prednisone cortical area of 0.53 between srednespisochnoe and significanoe cortical area is 0.35. Average zonal index of the left hemisphere was(0,29+0,37+0,31+0,26+0,53+0,35)=2,1; 2,1:6=0,35.
Indicators of coherence in the right hemisphere: between srednespisochnoe and frontal cortical area amounted to 0.15 Hz, between srednespisochnoe and Central cortical area to 0.18 Hz, between srednespisochnoe and parietal cortical area - 0,31 between srednespisochnoe and occipital cortical area to 0.14, between srednespisochnoe and prednisone cortical area - 0,32, between srednespisochnoe and significanoe cortical area to 0.21. Average zonal index of the right hemisphere was(0,15+0,18+0,31+0,14+0,32+0,21)=1,31; 1,31/6=0,22.
The coefficient of interhemispheric asymmetry (KMA) amounted to 0.35/0,22=1,59 (>1).
Thus, the data obtained KMA more than 1 meet the diagnosis of schizoaffective disorder, which coincides with the clinical diagnosis.
Patient treatment: antipsychotics - quetiapine 600 mg per day, zyprexa 20 mg per day, antidepressants - cipramil 30 mg per day.
H is the cut two weeks, the patient had marked improvement, disappeared affective tension and delusional idea of a relationship. By the end of the fourth week the mood smooth, delusional ideas are not expressed. Criticism to the full. Works returned to their former way of life.
In this way a differential diagnosis 29 patients with paranoid schizophrenia and schizoaffective disorder. The coincidence of the clinical and EEG data was noted in 79% of patients. The data obtained was statistically significant (p<0,05).
The proposed method has advantages over the known, which consists in increasing the accuracy and objectivity of diagnosis of patients with paranoid schizophrenia and schizoaffective disorder, which is set for the correct choice of therapeutic management, relapse prevention of these diseases, as well as expand the Arsenal of diagnostic methods.
The method of differential diagnosis of paranoid schizophrenia and schizoaffective disorder by clinical and EEG studies using coherent analysis of the electroencephalogram (EEG) in the range of 30-45 Hz to destination psychotropic substances, characterized in that in addition to the clinical study determine the average zonal indices of the left and right hemispheres, calculated between sredniowiecznymi and the following cortical areas: frontal, Central, those who nymi, occipital, prednisonum and zadnevisochnoy homolateral, calculate the coefficient of interhemispheric asymmetry (KMA) by dividing the average of the zonal index of the left hemisphere on average zonal index of the right hemisphere and at KMA less than 1 diagnosed with paranoid schizophrenia, a value of more than 1 schizoaffective disorder.
SUBSTANCE: invention refers to medicine, namely to psychiatrics. A clinical examination is combined with recording an electroencephalogram (EEG); its spectral and coherent analyses are carried out. The following values are determined: T6-AA-lead power spectrum within the range of 3.5-5 Hz, F7-AA-lead power spectrum within the range of 2-3 Hz, T5-AA -lead power spectrum within the range of 23-24.5 Hz, hemispheric power asymmetry between F8-AA and F7-AA-leads within the range of 24.5-26 Hz, P4-C4-lead coherence within the range of 8-13 Hz, T4-F8 within the range of 23-24.5 Hz, T3-F7-lead power spectrum within the range of 26-27.5 Hz, T5-O1 within the range of 17-18.5 Hz, T3-F8 within the range of 20-21.5 Hz. Logarithms of the derived values are calculated. An integral diagnostic value is determined by mathematical formula taking into account the calculated logarithm and coefficient-corrective values. If the integral diagnostic value appears to be positive, a recurrent depressive disorder is diagnosed, while a bipolar affective disorder is shown by the negative integral diagnostic value.
EFFECT: method enables providing higher diagnostic reliability at the early stages of the disease that is ensured by the optimum selection of the values, and the mathematical calculation of the integral value.
SUBSTANCE: invention refers to medicine, labour safety, vocational selection of rescue workers. The invention can be used for vocational selection in the sectors of industry using personal protective equipment, as well as for the workers labour safety in the sectors of industry with harmful working conditions. The method involves vocational selection and duty control on the basis of electroencephalogram (EEG) values and cardiological findings. The examination is performed prior to and when using the personal protective equipment. The cardiological examination involves assessing the heart rate variability with using the amplitude-frequency spectrum Fourier analysis VLF at a vibration frequency within the range of 0.0033-0.04 Hz, LF - at a frequency of 0.05-0.15 Hz and HF - at a frequency of 0.16-0.80 Hz, and is five-staged: initial resting state, mental work load, recovery of mental work load, hyperventilation load, recovery of hyperventilation load. At the beginning, the heart rate variations and EEG are examined prior to using the personal protective equipment. If any of the five stages of the heart rate variation examination shows the pulse more than 90 beats per minute, as well as changes from the normal values of: approximating entropy - less than 180, LF - less than 6 point, an alpha wave amplitude - to 12 vibrations per second and the presence of the paroxysmal activity by EEG, the prevailing sympathetic nervous system is stated, or if any stage of the heart rate variation examination shows the pulse less than 60 beats per minute, as well as changes from the normal values of: blood pressure - more than 140/90 mmHg, VLF - more than 130 points, HF - more than 16 points, an alpha wave amplitude - less than 25 mcV, the prevailing parasympathetic nervous system is stated; a low level of adaptation to the personal protective equipment is predicted, and a rescue work is not recommended during the vocational selection; the examination is terminated. If the heart rate variation and EEG prior to using the personal protective equipment fall within the normal values, the heart rate variation when using the personal protective equipment is started with the patient examined when using the personal protective equipment and performing a cycle ergometer test, and recording the hyperadaptotic changes of the assessed values: VLF - more than 130 points in relation to the normal value when using the personal protective equipment and LF and HF vibrations; an incomplete or unfinished adaptation to the personal protective equipment, and the rescue worker is suspended from work for several hours; if VLF is more than 130 points recorded 10-15 min after activating the personal protective equipment, a good adaptation level to the personal protective equipment is predicted.
EFFECT: method enables assessing the vegetative nervous function and predicting the rescue workers' adaptation level to the personal protective equipment.
11 tbl, 5 ex
SUBSTANCE: patient is trained by challenging to imagine a paretic limb movement and controlling the imagined movement. An electroencephalography is recorded; the recorded data are transferred to a computer for synchronous processing, and arousal reaction signals of a sensorimotor rate responsible for the imagined movement are isolated by means of an EEG pattern classifier according to the Bayes method. Identification results of the mental challenge are presented to the patient by a visual feedback in the form of a mark on a monitor. The mark re-position testifies to accuracy of the challenge. The imagined movement challenge is presented for 10 seconds. The training course makes 6-12 days, one training a day, of the length of 20-30 minutes every 1 to 4 days.
EFFECT: method provides more effective rehabilitation that is ensured by the feedback training in the conditions enabling the patient controlling the imagined paretic limb movement visually.
3 dwg, 4 tbl, 2 ex
SUBSTANCE: method includes rendering an image which creates a depth and volume effect (IDE); detecting electrical activity (EEG) of the brain for white sheet (IWS) rendering and for image IDE rendering; calculating the sum of the overall coherence amplitude on all derivations and components of EEG rhythms, first for IWS rendering
EFFECT: method enables to obtain an objective evaluation of the capability for three-dimensional sensing of flat images, which is achieved owing to use of coherent EEG analysis.
SUBSTANCE: invention refers to medicine, and may be used in occupational pathology. Person's open eyes are exposed to a white light of a colour temperature varying within the range of 1700 K - 10000 K. An electroencephalogram is recorded; its spectral analysis is performed to state the effect to be activating as shown by a power spectrum of alpha and theta waves reducing by more than 25% of background values.
EFFECT: method enables an individual selection of a colour temperature having the activating effect.
2 tbl, 2 ex
SUBSTANCE: invention refers to medicine and may be used for assessing the light exposure generated by a light-emitting-diode source on the functional status of human brain cortex. The white light exposure covers individual's open eyes at colour temperature 1700-10000 °K, illumination 80-300 lx at the eye level. That is followed by electroencephalogram recording and spectral analysis. If observing an increase or a decrease of alpha or teta wave spectral power by more than 25% of a baseline value, the light exposure is considered to be physiologically active, and by less than 25% - as physiologically neutral.
EFFECT: method provides more reliable assessment of the functional status of human brain that is ensured by biological activity rating within the alpha and teta wave range.
4 tbl, 4 ex
SUBSTANCE: invention refers to medicine, and may be used for changing the functional status of an individual. The individual's open eyes are exposed to white light at colour temperature 1700 °K or 10000 °K, at lighting intensity 200 lx at the eye level. That is followed by electroencephalogram recording and spectral analysis. If an alpha wave spectral power increases by more than 50%, while a teta wave spectral power increases by more than 25% of a baseline value, the effect is considered to be relaxant.
EFFECT: method enables assessing the action of colour temperature individually that can cause the relaxant effect on an individual.
2 tbl, 2 ex
SUBSTANCE: invention refers to medicine, namely dentistry. An encephalogram (EEG) is recorded in patients with the disturbed cerebral hemodynamics. The EEG is repeated with an occlusal load using 10-20 g of comb honey for 3-4 minutes. If a post-therapeutic alpha rhythm recovers or prevails on the EEG, the conducted orthopaedic alignment is considered to be effective.
EFFECT: method provides more reliable estimation of the orthopaedic alignment of dental patients suffering a cerebrovascular pathology that is ensured by using the occlusal load.
4 dwg, 1 ex
SUBSTANCE: invention refers to medicine and may be used to estimate the indications for prescribing drug preparations incompatible with alcohol ingestion, in addictology, psychiatry, as well as psychotherapy. There are performed electroencephalography and psychological testing: the first stage involves electroencephalography (EEG) in the patients diagnosed with alcohol dependence syndrome for the presence of short wave, desynchronosis and asymmetric bioelectric brain activity, disturbed alpha activity; the given study aims at finding the presence or absence of an organic pathology of brain functioning related to disturbed bioelectric activity. At the second stage, the patients with EEG findings showing no signs of an organic brain involvement are estimated considering the personal nonverbal emotional attitude system using colour repertory grid (CRG) techniques with using groups of alcohol-related objects and displaying Luscher colour cards. Pearson linear correlation coefficients of the elements and constructs to be further processed using a principal component analysis procedure. The detected factor loadings of the two most important components are used as two-dimensional element coordinates when constructing a graphical model of the attitude system of the person being tested. The presence of high conformity in the two representational personal emotional attitude system (verbal and nonverbal) gives evidence of the intact and adequate personality motivation sphere and serves as an indication for prescribing drug preparations of opioid receptor antagonists (naltrexone) and a cognitive behaviour therapy of alcohol dependency. The presence of low conformity is a sign of such disturbances of the motivation sphere that neutralise possibilities of psychotherapeutic methods and serves as a proof for prescribing drug preparations incompatible with alcohol ingestion (disulphiram, cyanamide).
EFFECT: method enables the objective and accurate estimation of the correctness of indications in predicting the effective use of drug preparations incompatible with alcohol ingestion, within the alcohol dependence therapy.
SUBSTANCE: invention refers to medicine, namely to anaesthesiology, and may be used in assessing an adequate general anaesthesia in the children aged from 4 to 14 years old. That is ensured by pre-anaesthetic and intra-anaesthetic intraoperative recording of long-latency auditory evoked potentials. That is followed by summing up initial latencies of first three pre-anaesthetic peaks (P1, N1, P2) to calculate sum A, subtracting the sum of the latencies of the first three intraoperative peaks (P1, N1, P2) to calculate sum B. The A to B relation is multiplied by 100. A percentage of the latencies of the intra-anaesthetic peaks P1, N1, P2 to the pre-anaesthetic values is considered as the adequate general anaesthesia. For the children of the first age group of 4-6 years old, the general anaesthesia is considered to be adequate, if the percentage is 140-253%; for the children of the second age group of 7-9 years old, the adequate general anaesthesia is shown by the percentage of 133-253%; for the children of the third age group of 10-12 years old, the adequate anaesthesia is shown by the percentage of 159-190%; and the percentage of 125-271% provides the adequate general anaesthesia for the children of the fourth age group of 13-14 years old.
EFFECT: method provides the adequate and easy assessment of the anaesthesia ensured by reducing a time of examination and simplicity of data interpretation in the form of one three-peak wave.
1 ex, 6 tbl
FIELD: medicine, neurology, psychopathology, neurosurgery, neurophysiology, experimental neurobiology.
SUBSTANCE: one should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another.
EFFECT: higher accuracy of diagnostics.
5 dwg, 1 ex, 1 tbl
FIELD: medicine, neurology.
SUBSTANCE: one should establish neurological status, bioelectric cerebral activity, availability of perinatal and ORL pathology in patients, establish their gradations and numerical values followed by calculation of prognostic coefficients F1 and F2 by the following formulas: F1=-31,42+1,49·a1-2,44·a2+0,2·а3+1,63·a4+0,62·а5+3,75·a6+1,8·а7-3,23·a8-0,8·а9-1,32·а10+3,26·а11+8,92·a12-2,0·a13+3,88·а14+1,79·a15+0,83·a16-2,78·a17; F2=-27,58+1,43·a1+3,31·а2+0,08·а3+3,05·а4-0,27·а5+2,69·а6+3,11·а7-6,47·a8-6,55·a9+1,99·а10+5,25·а11+7,07·a12-0,47·a13+0,13·a14+4,04·a15-1,0·a16-1,14·а17, correspondingly, where a1 - patient's age, a2 - studying either at the hospital or polyclinic, a3 - duration of stationary treatment (in days), a4 - unconscious period, a5 - terms of hospitalization since the moment of light close craniocerebral trauma, a6 - smoking, a7 - alcohol misuse, a8 - arterial hypertension, a9 - amnesia, a10 - close craniocerebral trauma in anamnesis, a11 - psychoemotional tension, a12 - meteolability, a13 - cervical osteochondrosis, a14 - ORL pathology, a15 - availability of perinatal trauma in anamnesis with pronounced hypertension-hydrocephalic syndrome, a16 - availability of paroxysmal activity, a17 - availability and manifestation value of dysfunction of diencephalic structures. At F1 ≥ F2 on should predict the development of remote aftereffects in young people due to evaluating premorbid background of a patients at the moment of trauma.
EFFECT: higher reliability of prediction.
2 ex, 1 tbl
FIELD: medicine; medical engineering.
SUBSTANCE: method involves doing multi-channel recording of electroencephalogram and carrying out functional tests. Recording and storing rheoencephalograms is carried out additionally with multi-channel recording of electroencephalogram synchronously and in real time mode in carotid and vertebral arteries. Electroencephalograms and rheoencephalograms are visualized in single window with single time axis. Functional brain state is evaluated from synchronous changes of electroencephalograms, rheoencephalograms and electrocardiograms in response to functional test. The device has electrode unit 1 for recording bioelectric brain activity signals, electrode unit 2 for recording electric cardiac activity signals, current and potential electrode unit 3 for recording rheosignals, leads commutator 4, current rheosignal oscillator 5, synchronous rheosignal detector 6, multi-channel bioelectric brain activity signals amplifier 7, electrophysiological signal amplifier 8, demultiplexer 9, multi-channel rheosignal amplifier 10, multi-channel analog-to-digital converter 11, micro-computer 12 having galvanically isolated input/output port and personal computer 13 of standard configuration.
EFFECT: enhanced effectiveness of differential diagnosis-making.
11 cl, 6 dwg
FIELD: medicine; medical engineering.
SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.
EFFECT: wide range of functional applications.
15 cl, 10 dwg
FIELD: medicine, psychiatry.
SUBSTANCE: one should conduct EEG-testing to detect total value of the indices of spectral power or percentage spectral power of delta- and teta-rhythms due to spectrometric technique in frontal, parietal, central and temporal areas both before and during emotional-negative loading when visual emotionally negative stimuli are presented followed by their imaginary reproduction. In case of higher indices to visual stimuli being above 15% against the background one should diagnose epilepsy. The method enables to increase the number of diagnostic means, increase accuracy and objectivity in predicting epilepsy with polymorphic paroxysms at dissociation of clinical and EEG-values.
EFFECT: higher efficiency of diagnostics.
1 ex, 1 tbl
FIELD: medicine, neurophysiology.
SUBSTANCE: one should carry out EEG survey to detect spectrometrically the index of full range if alpha-rhythm both before and after therapy. Moreover, power index of full range of alpha-rhythm and the index of 9-10 Hz-strip's spectral power should be detected in occipital cerebral areas. One should calculate the value of the ratio of the index of 9-10 Hz-strip's spectral power to the index of full range of alpha-rhythm and at the increase of this value by 20% against the background it is possible to evaluate positive result of therapy. The method increases the number of diagnostic means applied in evaluating therapeutic efficiency in the field of neurophysiology.
EFFECT: higher efficiency of evaluation.
FIELD: medicine, neurology.
SUBSTANCE: method involves carrying out the standard vascular and nootropic therapy. Diazepam is administrated under EEG control with the infusion rate that is calculated by the following formula: y = 0.0015x - 0.025 wherein y is the rate of diazepam administration, mg/h; x is an average EEG amplitude, mcV. Method provides enhancing the effectiveness of treatment of patients. Invention can be used for treatment of patients in critical severe period of ischemic insult.
EFFECT: enhanced effectiveness of treatment.
2 tbl, 1 dwg, 1 ex
SUBSTANCE: method involves selecting signals showing patient consciousness level and following evoked auditory potentials as responses to repeating acoustic stimuli, applying autoregression model with exogenous input signal and calculating AAI index showing anesthesia depth next to it.
EFFECT: quick tracing of unconscious to conscious state and vice versa; high accuracy of measurements.
9 cl, 3 dwg
FIELD: medicine; experimental and medicinal physiology.
SUBSTANCE: device can be used for controlling changes in functional condition of central nervous system. Device has receiving electrodes, unit for reading electroencephalograms out, analog-to-digital converter and inductor. Low noise amplifier, narrow band filter linear array which can be program-tuned, sample and store unit, online memory, microcontroller provided with controlled permanent storage, liquid-crystal indicator provided with external control unit are introduced into device additionally. Receiving electrodes are fastened to top part of patient's head. Outputs of electrodes are connected with narrow band filters linear array through electroencephalograph. Output of linear array is connected with input of input unit which has output connected with input of analog-to-digital converter. First bus of analog-to-digital converter is connected with online storage. Recording/reading bus of microcontroller is connected with control input of input unit and its starting bus is connected with address input of online storage. Third control bus is connected with narrow band filters linear array. Second control bus is connected with liquid-crystal indicator. Output bus is connected with inductor. External control (keyboard) of first control bus is connected with microcontroller. Output of online storage is connected with data input of microcontroller through 12-digit second data bus. Efficiency of influence is improved due to getting specific directed influence being based onto general technological transparency of processing of human brain's signals and strictly specific influence based on the condition of better stimulation.
EFFECT: increased efficiency.
3 cl, 1 dwg, 1 tbl
FIELD: medicine, neurology, professional pathology.
SUBSTANCE: one should carry out either biochemical blood testing and electroencephalography or SMIL test, or ultrasound dopplerography of the main cranial arteries, rheoencephalography (REG) to detect the volume of cerebral circulation and hypercapnic loading and their digital values. Then it is necessary to calculate diagnostic coefficients F by the following formulas: Fb/e=6.3-0.16·a1+0.12·a2-1·a3+0.2·a4, or FSMIL=9.6+0.16·a5-0.11·a6-0.14·a7+0.07·a8, or Fhem=48.6-0.04·a9+0.15·a10+13.7·a11-0.02·a12+24.7·a13, where Fb/e -diagnostic coefficient for biochemical blood testings and EEG; FSMIL - diagnostic coefficient for SMIL test; Fhem - diagnostic coefficient for hemodynamic testing; 6.3; 9.6 and 48.6 - constants; a1 - the level of vitamin C in blood; a2 - δ-index by EEG; a3 - atherogenicity index; a4 - the level of α-proteides in blood; a5 - scale 3 value by SMIL; a6 - scale K value by SMIL; a7 - scale 5 value by SMIL; a8 - scale 7 value by SMIL; a9 - the level of volumetric cerebral circulation; a10 - the value of linear circulatory rate along total carotid artery, a11 - the value of resistive index along total carotid artery; a12 - the value for the tonicity of cerebral vessels at carrying out hypercapnic sampling by REG; a13 - the value for the intensity of cerebral circulation in frontal-mastoid deviation by REG. At F value being above the constant one should diagnose toxic encephalopathy, at F value being below the constant - discirculatory encephalopathy due to applying informative values.
EFFECT: higher accuracy of diagnostics.
6 ex, 1 tbl