Early differential diagnostic technique for bipolar affective and recurrent depressive disorders

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to psychiatrics. A clinical examination is combined with recording an electroencephalogram (EEG); its spectral and coherent analyses are carried out. The following values are determined: T6-AA-lead power spectrum within the range of 3.5-5 Hz, F7-AA-lead power spectrum within the range of 2-3 Hz, T5-AA -lead power spectrum within the range of 23-24.5 Hz, hemispheric power asymmetry between F8-AA and F7-AA-leads within the range of 24.5-26 Hz, P4-C4-lead coherence within the range of 8-13 Hz, T4-F8 within the range of 23-24.5 Hz, T3-F7-lead power spectrum within the range of 26-27.5 Hz, T5-O1 within the range of 17-18.5 Hz, T3-F8 within the range of 20-21.5 Hz. Logarithms of the derived values are calculated. An integral diagnostic value is determined by mathematical formula taking into account the calculated logarithm and coefficient-corrective values. If the integral diagnostic value appears to be positive, a recurrent depressive disorder is diagnosed, while a bipolar affective disorder is shown by the negative integral diagnostic value.

EFFECT: method enables providing higher diagnostic reliability at the early stages of the disease that is ensured by the optimum selection of the values, and the mathematical calculation of the integral value.

2 ex

 

The invention relates to medicine, namely to psychiatry, and concerns the neurophysiology of mental disorders.

The problem of early differential diagnosis of bipolar and recurrent depressive disorders is relevant in the early stages, when the first attacks of the disease, which has implications for the choice of therapeutic management of a specified group of patients.

A known method of differential diagnosis of bipolar and recurrent depressive disorders by conducting clinical research (Krasnov Century. N. The affective disorder spectrum. - M.: Practical medicine, 2011, S. 51, 72). The disadvantages of this method are the subjectivity of the assessment, depending on the qualification of the doctor, as well as the difficulties of diagnosis in the initial stages of the disease.

A known method of differential diagnosis of bipolar and recurrent depressive disorders by electroencephalographic studies (EEG) with carrying out spectral analysis and inference of the regression equation (Melnikova I. S. Neurophysiological analysis of depression in patients with affective psychosis // Diss. on competition of a scientific degree of the doctor of biological Sciences. - M., 1992, S. 196, 197). The disadvantages of this method are the low diagnostic accuracy.

Technical is Kim a result of the proposed solutions is expanding Arsenal of diagnostic methods, improving the accuracy and objectivity for the early differential diagnosis of bipolar and recurrent depressive disorders, which contributes to the selection of adequate therapy.

This result is achieved in that in addition to clinical simultaneously carry out spectral and coherence analysis of the EEG, determine 9 the following figures (I-IX): spectral power at standard leads T6-AA in the range of 3.5-5 Hz (I), F7-AA in the range of 2-3 Hz (II), T5-AA in the range of 23-24,5 Hz (III); hemispheric asymmetry of power between the leads F8-F7 AA and AA in the range of 24.5-26 Hz (IV)coherence on leads P4-C4 in the range 8-13 Hz (V), T4 F8 in the range of 23-24,5 Hz (VI), T3-F7 in the range of 26-27,5 Hz (VII), T5-O1 in the range 17-18,5 Hz (VIII), T3-F8 in the range of 20-21,5 Hz (IX), compute the logarithms of the received indicators and indicators of coherence (Son) is pre-calculated according to the formula (Son2/(1-Son2)); integral diagnostic indicator (Y) is determined by the formula

Y=-1,274 Ln(I)+0,727 Ln(II)-0,898 Ln(III)-1,419 Ln(IV)+1,247 Ln(V2/(1-V2))+0,521 Ln(VI2/(1-VI2))+0,582 Ln(VII2/(1-VII2))+1,28 Ln(VIII2/(1-III2))-0,436 Ln(IX2/(1-IX2))-3,367,

Where Ln(I, II, III) - natural logarithm of indexes of spectral power at different leads;

Ln(IV) is the natural logarithm of asymmetry indexes spectral power, rasschitannogo standard formula [(Spectral power(F8-AA)/Spectral power(F7-AA)];

Ln(V2/(1-V2)), (VI2/(1-VI2)), (VII2/(1-VII2)), (VIII2/(1-VIII2)), (IX2/(1-IX2))) is the natural logarithm of the indicators of coherence on different leads, calculated by the formula (Son2/(1-Son2));

(-1,274; 0,727; -0,898; -1,419; 1,247; 0,521; 0,582; 1,28; -0,436) - corrective coefficients indices;

(-3,367) - constant formulas;

and at positive values of the integral diagnostic indicator (Y more than zero) have a diagnosis of recurrent depressive disorder, negative (Y less than zero) bipolar affective disorder, with the subsequent appointment psychocorrection therapy.

The method is as follows.

The patient with a differential diagnosis of bipolar and recurrent depressive disorders in addition to conduct clinical EEG study using the standard method (Rusyn B. C. Clinical electroencephalography. - M.: Medicine, 1973, S. 19-29), while conducting spectral and coherence analysis of the EEG (Ivanov L. B. Applied computational electroencephalography. - M.: Publishing House. "Medical research firm NMG", 2004, S. 35-88; 89-181), determine 9 the following figures (I-IX): spectral power at standard leads - between the right posterior temporal and combined ear electrode (T6-AA) in the range of 3.5-5 Hz (I), between which the combat anterior temporal and combined ear electrodes (F7-AA) in the range 2-SGC (II), between the left posterior temporal and combined ear electrode (T5-AA) in the range of 23-24,5 Hz (III); hemispheric asymmetry of power between the right anterior temporal and combined ear electrode (F8-AA) and the left anterior temporal and combined ear electrodes (F7-AA) in the range of 24.5-26 Hz (IV), coherence in the leads between the right parietal and right Central (P4-C4) in the range of 8-13 Hz (V), between the right sredniowieczne and right prednisonum (T4 F8) in the range of 23-24,5 Hz (VI), between the left sredniowieczne and left prednisonum (T3-F7) in the range of 26-27,5 Hz (VII), between the left significany and left occipital (T5-01) in the range of 17-18,5 Hz (VIII), between the left sredniowieczne and right prednisonum (T3-F8) in the range of 20-21,5 Hz (IX). Compute the logarithms of the resulting figures, while the asymmetry of the spectral power is calculated by the standard formula [(Spectral power (F8-AA)/Spectral power (F7-AA)], and indicators of coherence pre-calculated according to the formula (Son2/(1-Son2)). Integral diagnostic indicator (Y) is determined by the formula

Y=-1,274 Ln(I)+0,727 Ln(II)-0,898 Ln(III)-1,419 Ln(IV)+1,247 Ln(V2/(1-V2))++0,521 Ln(VI2/(1-VI2))+0,582 Ln(VII2/(1-VII2))+1,28 Ln(VIII2/(1-VIII2))-0,436 Ln(IX2/(1-IX2))-3,367,

where Ln(I, II, III) - natural logarithm of indexes of spectral power at different leads;

n(IV) - the natural logarithm of asymmetry indexes spectral power calculated by the formula [(Spectral power(F8-AA)/Spectral power(F7-AA)];

Ln[(V2/(1-V2)), (VI2/(1-VI2)), (VII2/(1-VII2)), (VIII2/(1-VIII2)), (IX2/(1-IX2))] natural logarithms of the indices of coherence (V-IX) on different leads;

(-1,274; 0,727; -0,898; -1,419; 1,247; 0,521; 0,582; 1,28; -0,436) - corrective coefficients and (-3,367) - constant formulas calculated on the basis of statistical processing using discriminant analysis EEG data of 46 patients with clinically verified diagnosis of bipolar and 97 - recurrent depressive disorders.

At positive values of the integral diagnostic indicator (Y more than zero) have a diagnosis of recurrent depressive disorder, negative (Y less than zero) bipolar affective disorder, with subsequent assignment psychocorrection therapy.

Example 1. Patient E., 1958 R., medical card No. 02673/09. Entered 4 Department of the fgbi "MNIIP" Ministry of health of Russia 12.08.09. Diagnosis: Recurrent depressive disorder, current episode moderate severity of somatic symptoms? Bipolar affective disorder?

Mentally ill since 1985, when disturbed sleep, appeared irritable, tired is here, lost weight, decreased appetite, disturbed anxiety, loss of enjoyment out of what had delighted, began to tire of their favorite work. It was treated at the neuropathologist, the mood returned to normal after 2 months. Since the spring of 2008 in the face of chronic stress began to experience bouts of anxiety, accompanied by trembling hands, feeling the heat in the chest, lifts HELL, during these periods, they called the ambulance, the doctors diagnosed anxiety disorder with panic attacks. From this time became closely relate to their health, avoided being away from home and places will not be able to help. In the summer of 2008 began to experience mild anxiety, decreased mood, "faded colors". In November 2008 he developed pancreatitis and was hospitalized. The mood is further decreased, appeared despair, began to withdraw into themselves, to listen to the sensations in the body. After discharge from the hospital every month for blood tests to check the function of the pancreas, have limited myself to eat, could not concentrate at work, all my thoughts were about his health, he feared the development of an attack of pancreatitis, felt the pressure behind the sternum - "heartache". In February 2009, appealed to the mental hospital at the place of residence, and forwarded to the fgbi "MNIIP" Ministry of health of Russia. Upon receipt 12.08.09 complained about the decrease in n the structure, "sinking" feeling, the mood was characterized by depressed-anxious affect, with a predominance of anxiety, felt worse in the morning, hypochondriasis was fixed on her current state, feared that the state "will further deteriorate". Sleep was characterized by multiple awakenings during the night, early morning awakening with anxiety and heat in the body. Noted discomfort in the chest: "heart sick".

After clinical examination, the patient was conducted EEG study using the standard method with the simultaneous holding of spectral and coherence analyses. Defined and calculated 9 EEG (I-IX):

(I) is the spectral power at standard lead (T6-AA) in the range of 3.5-5 Hz was 1,598; (II) is the spectral power at standard lead (F7-AA) in the range of 2-3 Hz was 2,009; (III) is the spectral power at standard lead (T5-AA) in the range of 23-24,5 Hz was 0,231; (IV) the asymmetry of power (F8-AA/F7-AA), in the range of 24.5-26 Hz was 2 (0,38/0,19); (V) - the coherence of the standard leads (P4-C4) in the range of 8-13 Hz was 0,768; (VI) the coherence of the standard leads (T4 F8) in the range of 23-24,5 Hz was 0,585; (VII) the coherence of the standard leads (T3-F7) in the range of 26-27,5 Hz was 0,677; (VIII) the coherence of the standard leads (T5-O1) in the range of 17-18,5 G who was 0,575; (IX) the coherence of the standard leads (T3-F8) in the range of 20-21,5 Hz was 0,123.

They were followed by taking the logarithm of the spectral indices analysis (I-III), asymmetry of the spectral power (IV) and coherence (V-IX).

The following results are obtained:

Ln(I)=Ln(1,598)=0,463;

Ln(II)=Ln(2,009)=0,698;

Ln(III)=Ln(0,231)=-1,465;

Ln(IV)=Ln(2)=0,693.

Indicators of coherence (V-IX) pre-calculated by the formula (Son2/(1-Son2)):

Ln(CohV2/(1-CohV2))=Ln(0,7682/(1-0,7682))=Ln(0,5898/0,4102)=Ln(1,4378)=0,363;

Ln(CohVI2/(1-CohVI2))=Ln(0,5852/(1-0,5852))=Ln(0,3422/0,6578)=Ln(0,5202)=-0,654;

Ln(CohVII2/(1-CohVII2))=Ln(0,6772/(1-0,6772))=Ln(0,4583/0,5417)=Ln(0,846)=-0,167;

Ln(CohVIII2/(1-CohVIII2))=Ln(0,5752/(1-0,5752))=Ln(0,3306/0,6694)=Ln(0,4939)=-0,705;

Ln(CohIX2/(1-CohIX2))=Ln(0,1232/(1-0,1232))=Ln(0,0151/0,9849)=Ln(0,0153)=-4,18.

Integral diagnostic indicator (Y) calculated by the formula

Y=-1,274 Ln(I)+0,727 Ln(II)-0,898 Ln(III)-1,419 Ln(IV)+1,247 Ln(V2/(1-V2))++0,521 Ln(VI2/(1-VI2))+0,582 Ln(VII2/(1-VII2))+1,28 Ln(VIII2/(1-VIII2))-0,436 Ln(IX2/(1-IX2))-3,367=(-1,274)×0,463+0,727×0,698-0,898×(-1,465)-1,419×0,693+1,247×0,363+0,521×(-0,654)+0,582×(-0,167)+1,28×(-0,705)-0,436×(-4,18)-3,367==(-0,59)+0,507+1,316-0,983+0,453-0,341-0,097-0,902+1,822-3,367=-2,182.

The data obtained (Y less than 0) correspond to the diagnosis of bipolar disorder. Was assigned as psychokinetically antidepressant and normotonic in the medium therapeutic doses, which contributed to the normalization of the state and formation of drug remission. The follow-up period of 4.5 years. The patient appeared hypomanic episodes and mixed States, the last episode of hypomania in February-March 2010.

Example 2. Patient S., 1974, p., medical card No. 2325/08. Entered 4 Department of the fgbi "MNIIP" Ministry of health of Russia 08.12.08.

Diagnosis: Recurrent depressive disorder, current episode moderate severity of somatic symptoms? Bipolar affective disorder?

Mentally ill since the autumn of 2005, when from heart failure, his mother died of the patient. Acutely experienced loss, felt that "a good life is over", appeared suicidal thoughts. Sought help from a psychiatrist, took alprazolam and pirazidol, after 2 months in a normal condition, continued to work. Within 2 years, felt good. Since the autumn of 2007 began to notice intermittent periods of depression caused by memories of the past (childhood, illness of the mother), this deterioration occurred 2-3 times per week. Since February 2008 have problems at work, within 6 months was a reorganization, "the situation was uncertain". Felt a sense of hopelessness, despair, failure to take their shooting". With June came the state of extreme depression, felt nespos is the competitiveness to cope with the situation, broken concentration. The times noted the emergence of anxiety at this time "ran out from work, phone calls to his father, to relieve the tension". In September 2008 he started a new job, but was not able to adapt, to understand new material, has exacerbated the feeling of depression, anxiety, felt its failure appeared severe sleep disorders. November 6, lost his job, after which the condition was further exacerbated by increased thoughts of their own inadequacy, I kept thinking about the loss of a job, there was a feeling of heaviness, squeezing in the chest. Spoke to the psychiatrist, took pirazidol to 125 mg per day., lerivon 15 mg overnight, alprazolam, Eglon, without any significant effect. 08.12.08 addressed in the fgbi "MNIIP" health Ministry of Russia for selection of therapy. At admission were complaining of low mood, extreme depression, expressed anxiety, chest pain, weakness, difficulty concentrating, dizziness, sleep disturbance, poor appetite. Objectively noted a strong anxiety that is close to the state of agitation, was fixed on the negative feelings about the lack of work, "of its own insolvency, the incurability of his condition". With distrusted the prescribed therapy, doubted the success of the treatment. After clinical examination, pain is WMD was conducted EEG study using the standard method with the simultaneous holding of spectral and coherence analyses. Defined and calculated 9 EEG (I-IX):

(I) is the spectral power at standard lead T6-AA in the range of 3.5-5 Hz was 1,684; (II) is the spectral power at standard lead F7-AA in the range 2-SGC amounted to $ 1,656; (III) is the spectral power at standard lead T5-AA in the range of 23-24,5 Hz was 0,991; (IV) the asymmetry of power (F8-AA/F7-AA), in the range of 24.5-26 Hz was 0,821 (0,495/0,603); (V) the coherence of the standard abstraction (P4-C4) in the range of 8-13 Hz was 0,873; (VI) the coherence of the standard leads (T4 F8) in the range of 23-24,5 Hz was 0,975; (VII) the coherence of the standard leads (T3-F7) in the range of 26-27,5 Hz was 0,784; (VIII) the coherence of the standard leads (T5-O1) in the range of 17-18,5 Hz was 0,539; (IX) the coherence of the standard leads (T3-F8) in the range of 20-21,5 Hz was 0,207.

They were followed by taking the logarithm of the performance of spectral analysis, the asymmetry of the spectral power and coherence.

The following results are obtained:

Ln(I)=Ln(1,684)=0,521;

Ln(II)=Ln(1,656)=0,504;

Ln(III)=Ln(0,991)=-0,009;

Ln(IV)=Ln(0,821)=-0,197.

Indicators of coherence (V-IX) pre-calculated by the formula

(Son2/(1-Son2)).

Ln(CohV2/(1-CohV2))=Ln(0,8732/(1-0,8732))=Ln(0,7621/0,2379)=Ln(3,2034)=1,164;

Ln(CohVI2/(1-CohVI2))=Ln(0,9752/(1-0,9752))=Ln(0,951/0,049)=Ln(19,408)=of 2.966;

Ln(CohVII2/(1-CoVII 2))=Ln(0,7842/(1-0,7842))=Ln(0,6147/0,3853)=Ln(1,595)=0,467;

Ln(CohVIII2/(1-CohVIII2))=Ln(0,5392/(1-0,5392))=Ln(0,2905/0,7095)=Ln(0,416)=-0,877;

Ln(CohIX2/(1-CohIX2))=Ln(0,2072/(1-0,2072))=Ln(0,0428/0,9572)=Ln(0,045)=-3,101.

Integral diagnostic indicator (Y) calculated by the formula

Y=-1,274 Ln(I)+0,727 Ln(II)-0,898 Ln(III)-1,419 Ln(IV)+1,247 Ln(V2/(1-V2))+0,521 Ln(VI2/(1-VI2))+0,582 Ln(VII2/(1-VII2))+1,28 Ln(VIII2/(1-VIII2))-0,436 Ln(IX2/(1-IX2))-3,367=-1,274×0,521+0,727×0,504-0,898×(-0,009)-1,419×(-0,197)+1,247×1,164++0,521×2,966+0,582×0,467+1,28×(-0,877)-0,436×(-3101)-3,367==-0,664+0,366+0,008+0,28+1,452+1,545+0,27-1,123+1,352-3,367=0,119.

The data obtained (Y greater than 0) correspond to the diagnosis of recurrent depressive disorder. Patient assigned psycho therapy antidepressant and tranquilizer (ludiomil 50 mg 3 times a day, clonazepam 1 mg at night).

In the first week of therapy has reduced the phenomenon of anxiety, but the mood remained depressed, with no one talked, most of the time spent in the chamber, obsessive thoughts about the job search. At the end of 2 weeks of therapy noted improvement has leveled the mood became more relaxed, took a painful experience, it became easier to focus on reading, literature in their field. Became more active, sociable, improved appetite, increased mood. 29.12.08 issued under observing the local psychiatrist at the place of residence. The follow-up period of 4.5 years. Confirmed the correctness of electroencephalographic diagnosis: during this period, the patient underwent two more major depressive episode of moderate severity of somatic symptoms and depressed-anxious leading affect.

In this way a differential diagnosis 143 patients. The coincidence of the clinical and EEG data observed in 97.9% of patients. The data obtained was statistically significant (p<0,05).

The proposed method has advantages over the known, which consists in the ability to diagnose in the early stages of the disease, improving the accuracy and objectivity of diagnosis of patients with bipolar and recurrent depressive disorders that is set for the correct choice of therapeutic management, relapse prevention of these diseases, as well as expanding the range of diagnostic methods for this group of patients.

The early differential diagnosis of bipolar and recurrent depressive disorders by clinical and electroencephalographic studies of spectral and coherence analysis of the electroencephalogram (EEG), characterized in that in addition to clinical simultaneously carry out spectral and coherence analysis of the EEG, determine 9 the following figures (I-IX): spectral mo is the ability for standard leads T6-AA in the range of 3.5-5 Hz (I), F7-AA in the range of 2-3 Hz (II), T5-AA in the range of 23-24,5 Hz (III); hemispheric asymmetry of power between the leads F8-F7 AA and AA in the range of 24.5-26 Hz (IV)coherence on leads P4-C4 in the range of 8-13 Hz (V), T4 F8 in the range of 23-24,5 Hz (VI), T3-F7 in the range of 26-27,5 Hz (VII), T5-O1 in the range 17-18,5 Hz (VIII), T3-F8 in the range of 20-21,5 Hz (IX), compute the logarithms of the received indicators and indicators of coherence (Son) is pre-calculated according to the formula (Son2/(1-Son2)); integral diagnostic indicator (Y) is determined by the formula
Y=-1,274 Ln(I)+0,727 Ln(II)-0,898 Ln(III)-1,419 Ln(IV)+1,247 Ln(V2/(1-V2))+0,521 Ln(VI2/(1-VI2))+0,582 Ln(VII2/(1-VII2))+1,28 Ln(VIII2/(1-VIII2))-0,436 Ln(IX2/(1-IX2))-3,367,
where Ln(I, II, III) - natural logarithm of indexes of spectral power at different leads;
Ln(IV) is the natural logarithm of asymmetry indexes spectral power;
Ln[(V2/(1-V2)), (VI2/(1-VI2)), (VII2/(1-VII2)), (VIII2/(1-VIII2)), (IX2/(1-IX2))] is the natural logarithm of the indicators of coherence (V-IX) on different leads, calculated by the formula (Son2/(1-Son2));
(-1,274; 0,727; -0,898; -1,419; 1,247; 0,521; 0,582; 1,28; -0,436) - correction factors indicators; (-3,367) - constant formulas;
and at positive values of the integral diagnostic indicator (Y more than zero) diagnose p is currentnode depressive disorder, when negative (Y less than zero) bipolar affective disorder, with the subsequent appointment psychocorrection therapy.



 

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1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to anaesthesiology, and may be used in assessing an adequate general anaesthesia in the children aged from 4 to 14 years old. That is ensured by pre-anaesthetic and intra-anaesthetic intraoperative recording of long-latency auditory evoked potentials. That is followed by summing up initial latencies of first three pre-anaesthetic peaks (P1, N1, P2) to calculate sum A, subtracting the sum of the latencies of the first three intraoperative peaks (P1, N1, P2) to calculate sum B. The A to B relation is multiplied by 100. A percentage of the latencies of the intra-anaesthetic peaks P1, N1, P2 to the pre-anaesthetic values is considered as the adequate general anaesthesia. For the children of the first age group of 4-6 years old, the general anaesthesia is considered to be adequate, if the percentage is 140-253%; for the children of the second age group of 7-9 years old, the adequate general anaesthesia is shown by the percentage of 133-253%; for the children of the third age group of 10-12 years old, the adequate anaesthesia is shown by the percentage of 159-190%; and the percentage of 125-271% provides the adequate general anaesthesia for the children of the fourth age group of 13-14 years old.

EFFECT: method provides the adequate and easy assessment of the anaesthesia ensured by reducing a time of examination and simplicity of data interpretation in the form of one three-peak wave.

1 ex, 6 tbl

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to neurophysiological methods of examination. Registration of EEG is carried out, total power of modal fluctuation in alpha-rhythm range in one of leads is determined and FRα1 index is calculated as ration of said power to total power of all alpha range fluctuations in the same lead. Value of the sum of power of fluctuations, located ±0.5 Hz on the right and on the left from maximal power value, including maximal value, is determined, and FRα2 index is calculated as ratio of the obtained sum of power to total power of all fluctuations of alpha-range in the same lead. Intensity of brain affection is determined by comparison of obtained FRα1 and FRα2 values with standard values.

EFFECT: method makes it possible to determined quantitative ratio of alpha-rhythm, characteristic of separate nosologic units in psychiatry.

2 tbl, 1 dwg

FIELD: medicine, neurology, psychopathology, neurosurgery, neurophysiology, experimental neurobiology.

SUBSTANCE: one should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another.

EFFECT: higher accuracy of diagnostics.

5 dwg, 1 ex, 1 tbl

FIELD: medicine, neurology.

SUBSTANCE: one should establish neurological status, bioelectric cerebral activity, availability of perinatal and ORL pathology in patients, establish their gradations and numerical values followed by calculation of prognostic coefficients F1 and F2 by the following formulas: F1=-31,42+1,49·a1-2,44·a2+0,2·а3+1,63·a4+0,62·а5+3,75·a6+1,8·а7-3,23·a8-0,8·а9-1,32·а10+3,26·а11+8,92·a12-2,0·a13+3,88·а14+1,79·a15+0,83·a16-2,78·a17; F2=-27,58+1,43·a1+3,31·а2+0,08·а3+3,05·а4-0,27·а5+2,69·а6+3,11·а7-6,47·a8-6,55·a9+1,99·а10+5,25·а11+7,07·a12-0,47·a13+0,13·a14+4,04·a15-1,0·a16-1,14·а17, correspondingly, where a1 - patient's age, a2 - studying either at the hospital or polyclinic, a3 - duration of stationary treatment (in days), a4 - unconscious period, a5 - terms of hospitalization since the moment of light close craniocerebral trauma, a6 - smoking, a7 - alcohol misuse, a8 - arterial hypertension, a9 - amnesia, a10 - close craniocerebral trauma in anamnesis, a11 - psychoemotional tension, a12 - meteolability, a13 - cervical osteochondrosis, a14 - ORL pathology, a15 - availability of perinatal trauma in anamnesis with pronounced hypertension-hydrocephalic syndrome, a16 - availability of paroxysmal activity, a17 - availability and manifestation value of dysfunction of diencephalic structures. At F1 ≥ F2 on should predict the development of remote aftereffects in young people due to evaluating premorbid background of a patients at the moment of trauma.

EFFECT: higher reliability of prediction.

2 ex, 1 tbl

FIELD: medicine; medical engineering.

SUBSTANCE: method involves doing multi-channel recording of electroencephalogram and carrying out functional tests. Recording and storing rheoencephalograms is carried out additionally with multi-channel recording of electroencephalogram synchronously and in real time mode in carotid and vertebral arteries. Electroencephalograms and rheoencephalograms are visualized in single window with single time axis. Functional brain state is evaluated from synchronous changes of electroencephalograms, rheoencephalograms and electrocardiograms in response to functional test. The device has electrode unit 1 for recording bioelectric brain activity signals, electrode unit 2 for recording electric cardiac activity signals, current and potential electrode unit 3 for recording rheosignals, leads commutator 4, current rheosignal oscillator 5, synchronous rheosignal detector 6, multi-channel bioelectric brain activity signals amplifier 7, electrophysiological signal amplifier 8, demultiplexer 9, multi-channel rheosignal amplifier 10, multi-channel analog-to-digital converter 11, micro-computer 12 having galvanically isolated input/output port and personal computer 13 of standard configuration.

EFFECT: enhanced effectiveness of differential diagnosis-making.

11 cl, 6 dwg

FIELD: medicine; medical engineering.

SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.

EFFECT: wide range of functional applications.

15 cl, 10 dwg

FIELD: medicine, psychiatry.

SUBSTANCE: one should conduct EEG-testing to detect total value of the indices of spectral power or percentage spectral power of delta- and teta-rhythms due to spectrometric technique in frontal, parietal, central and temporal areas both before and during emotional-negative loading when visual emotionally negative stimuli are presented followed by their imaginary reproduction. In case of higher indices to visual stimuli being above 15% against the background one should diagnose epilepsy. The method enables to increase the number of diagnostic means, increase accuracy and objectivity in predicting epilepsy with polymorphic paroxysms at dissociation of clinical and EEG-values.

EFFECT: higher efficiency of diagnostics.

1 ex, 1 tbl

FIELD: medicine, neurophysiology.

SUBSTANCE: one should carry out EEG survey to detect spectrometrically the index of full range if alpha-rhythm both before and after therapy. Moreover, power index of full range of alpha-rhythm and the index of 9-10 Hz-strip's spectral power should be detected in occipital cerebral areas. One should calculate the value of the ratio of the index of 9-10 Hz-strip's spectral power to the index of full range of alpha-rhythm and at the increase of this value by 20% against the background it is possible to evaluate positive result of therapy. The method increases the number of diagnostic means applied in evaluating therapeutic efficiency in the field of neurophysiology.

EFFECT: higher efficiency of evaluation.

1 ex

FIELD: medicine, neurology.

SUBSTANCE: method involves carrying out the standard vascular and nootropic therapy. Diazepam is administrated under EEG control with the infusion rate that is calculated by the following formula: y = 0.0015x - 0.025 wherein y is the rate of diazepam administration, mg/h; x is an average EEG amplitude, mcV. Method provides enhancing the effectiveness of treatment of patients. Invention can be used for treatment of patients in critical severe period of ischemic insult.

EFFECT: enhanced effectiveness of treatment.

2 tbl, 1 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: method involves selecting signals showing patient consciousness level and following evoked auditory potentials as responses to repeating acoustic stimuli, applying autoregression model with exogenous input signal and calculating AAI index showing anesthesia depth next to it.

EFFECT: quick tracing of unconscious to conscious state and vice versa; high accuracy of measurements.

9 cl, 3 dwg

FIELD: medicine; experimental and medicinal physiology.

SUBSTANCE: device can be used for controlling changes in functional condition of central nervous system. Device has receiving electrodes, unit for reading electroencephalograms out, analog-to-digital converter and inductor. Low noise amplifier, narrow band filter linear array which can be program-tuned, sample and store unit, online memory, microcontroller provided with controlled permanent storage, liquid-crystal indicator provided with external control unit are introduced into device additionally. Receiving electrodes are fastened to top part of patient's head. Outputs of electrodes are connected with narrow band filters linear array through electroencephalograph. Output of linear array is connected with input of input unit which has output connected with input of analog-to-digital converter. First bus of analog-to-digital converter is connected with online storage. Recording/reading bus of microcontroller is connected with control input of input unit and its starting bus is connected with address input of online storage. Third control bus is connected with narrow band filters linear array. Second control bus is connected with liquid-crystal indicator. Output bus is connected with inductor. External control (keyboard) of first control bus is connected with microcontroller. Output of online storage is connected with data input of microcontroller through 12-digit second data bus. Efficiency of influence is improved due to getting specific directed influence being based onto general technological transparency of processing of human brain's signals and strictly specific influence based on the condition of better stimulation.

EFFECT: increased efficiency.

3 cl, 1 dwg, 1 tbl

FIELD: medicine, neurology, professional pathology.

SUBSTANCE: one should carry out either biochemical blood testing and electroencephalography or SMIL test, or ultrasound dopplerography of the main cranial arteries, rheoencephalography (REG) to detect the volume of cerebral circulation and hypercapnic loading and their digital values. Then it is necessary to calculate diagnostic coefficients F by the following formulas: Fb/e=6.3-0.16·a1+0.12·a2-1·a3+0.2·a4, or FSMIL=9.6+0.16·a5-0.11·a6-0.14·a7+0.07·a8, or Fhem=48.6-0.04·a9+0.15·a10+13.7·a11-0.02·a12+24.7·a13, where Fb/e -diagnostic coefficient for biochemical blood testings and EEG; FSMIL - diagnostic coefficient for SMIL test; Fhem - diagnostic coefficient for hemodynamic testing; 6.3; 9.6 and 48.6 - constants; a1 - the level of vitamin C in blood; a2 - δ-index by EEG; a3 - atherogenicity index; a4 - the level of α-proteides in blood; a5 - scale 3 value by SMIL; a6 - scale K value by SMIL; a7 - scale 5 value by SMIL; a8 - scale 7 value by SMIL; a9 - the level of volumetric cerebral circulation; a10 - the value of linear circulatory rate along total carotid artery, a11 - the value of resistive index along total carotid artery; a12 - the value for the tonicity of cerebral vessels at carrying out hypercapnic sampling by REG; a13 - the value for the intensity of cerebral circulation in frontal-mastoid deviation by REG. At F value being above the constant one should diagnose toxic encephalopathy, at F value being below the constant - discirculatory encephalopathy due to applying informative values.

EFFECT: higher accuracy of diagnostics.

6 ex, 1 tbl

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