Microencapsulated insecticide with enhanced residual activity

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. The method includes providing at least one insecticide, at least one esterified fatty acid, where the esterified fatty acid is methyl oleate, at least one cross-linking agent and at least one type of monomer; mixing the insecticide, the esterified fatty acid, the at least one cross-linking agent and at least one type of monomer, and forming a polymeric microcapsule shell which at least partially encapsulates a portion of the insecticide and a portion of the esterified fatty acid to form a microencapsulated insecticidal formulation. The microencapsulated insecticidal formulation contains chlorpyrifos-methyl, methyl oleate and a microcapsule shell containing polyurea.

EFFECT: invention prolongs the field life of the insecticide.

16 cl, 9 tbl

 

Cross-reference to related applications

This application claims the priority of provisional patent application U.S. No. 61/157197, filed on March 4, 2009, the contents of which are fully incorporated into the present description by reference.

The technical field to which the invention relates.

Various aspects and embodiments of the present invention relate primarily to the drugs microencapsulating pesticides exhibiting useful biological, commercial and/or environmental properties, including effective long periods of insecticidal activity after their application.

Background of invention

Regulation of the insect population is important for modern agriculture, storage of food and hygiene. Currently a significant role in the regulation of insect play safe and effective encapsulated insecticidal preparations. Useful properties of the encapsulated insecticidal preparations include sufficient effectiveness against pests, to whom their impact, including sufficient initial toxicity against insects that are subject to impact, easy handling, stability, the effective residence time in the environment and, in some cases, long-term effectiveness of the initial period of insecticidal activity after their application to areas, the neighboring population of insects.

Almost all insecticidal drugs that lose their ability to kill insects or to regulate their numbers, you need to reapply, resulting in increased material costs and labor costs. In addition, the use of drugs with a short-term continuing activity after their application may be periods during which the surface adjacent to the insect population, are vulnerable to contamination by pests. There is therefore a need in insecticidal preparations which retains its activity over an extended period of time after their application. In the present description discloses various aspects and embodiments of the present invention, which is directed to meet the needs in insecticidal preparations which retains its ability to kill or repel insects for an extended period of time after application to the surface adjacent to the insect population.

The invention

One variant of implementation of the present invention is a method of obtaining drug microencapsulating insecticide, in which the drug retains its ability to kill or repel insects from the surface, SOS the days with the insect population, for at least 120 days after application on the surface. One such method includes following steps: providing at least one insecticide, esterified fatty acid, at least one monomer and cross-linking agent; mixing of insecticide, low-volatile component and at least one monomer; and condensation of the monomer with the formation of the polymer shell of the capsule, which at least partially encapsulates a portion of the insecticide and part of esterified fatty acids. In one embodiment, the present invention esterified fatty acid has the formula A, where a represents:

where R1represents an alkyl or alkenylphenol group with a straight or branched chain, having from 11 to 25 carbon atoms, and

R2represents an alkyl or alkenylphenol group with a straight or branched chain, having from 1 to 8 carbon atoms.

In one embodiment, the present invention ingredient of the drug, possess insecticidal activity, is organophosphate insecticide. In one embodiment, the present invention organophosphate insecticide selected from the group consisting of acetate, azinphos-methyl, Chlorfenvinphos, chlorethoxyfos, chlorine is perigosa, of diazinon, dimethoate, disulfoton, ethoprophos, fenitrothion, sanitary legislature, fenamiphos, fosthiazate, Malathion, methamidophos, methidathion, omethoate, oxydemeton-methyl, parathion, parathion-methyl, porata, phosmet, profenofos and trichlorfon.

In yet another embodiment of the present invention, the ingredient of the drug exhibiting insecticidal activity, is a chlorpyrifos-methyl.

In one embodiment of the present invention, the preparation includes the shell of the microcapsules, which at least partially contains the ingredient of the insecticidal activity and which is formed by interfacial polycondensation of at least one monomer, essentially insoluble in water, and one water-soluble monomer. Oil-soluble compounds that can be used for formation of the shell of the microcapsules, can be selected from the group consisting of diisocyanates, polyisocyanates, acid chlorides of decislon, acid chlorides of PolicyKit, sulphonylchloride and CHLOROFORMATES; water-soluble monomer, which can be used for formation of the shell may be selected from the group consisting of diamines, polyamines, water soluble diols and water soluble polyols. In some embodiments, implementation of the present invention phase interfacial polycondensation is carried out in risotti cross-linking agent, such as Amin.

In one embodiment, the present invention esterified acid in the product is methyl oleate.

One variant of implementation of the present invention involves the formation of microcapsules having a shell thickness of about 90 nm to about 150 nm. In yet another embodiment of the present invention, the shell of the microcapsules has a thickness from about 100 nm to about 130 nm. In yet another embodiment of the present invention, the shell of the microcapsules has a thickness of about 120 nm.

Another variant implementation of the present invention is a method of regulating the populations of insects that includes the following stages: providing insecticidal preparation that retains its ability to kill or repel insects on the surface adjacent to the insect population, for at least 120 days, and the application of the specified drug on the surface adjacent to the insect population. In yet another embodiment, the present invention specified drug retains its insecticidal activity or the ability to repel insects for at least 150 days, and in yet another embodiment of the present invention it retains its insecticidal activity for at least 170 days after application.

Od the n variant implementation of the present invention is a method of control of the insect population over an extended period of time after drug application, including the stage of providing insecticidal preparation having a shell of a microcapsule or a wall which at least partially surrounds the mixture containing the insecticide and esterified fatty acid (A), where

And represents:

where R1represents an alkyl or alkenylphenol group c straight or branched chain, having from 11 to 25 carbon atoms, and

R2represents an alkyl or alkenylphenol group c straight or branched chain, having from 1 to 8 carbon atoms.

In some embodiment, the insecticide is organophosphate insecticide, and a capsule formed by interfacial polycondensation of water-soluble monomer and the monomer is insoluble in water. Additional stages include, for example, application of the drug on the surface adjacent to the insect population.

In one embodiment of the present invention a method of regulating populations of insects includes microencapsulating preparation containing organophosphate insecticide. In one embodiment, organophosphate insecticide selected from the group consisting of acetate, azinphos-methyl, Chlorfenvinphos, chlorethoxyfos, chlorpyrifos, diazinon, dimethoate, disulfoton, ethoprophos, fenitrothion, sanitary legislature, tenamit the sa, fosthiazate, Malathion, methamidophos, methidathion, omethoate, oxydemeton-methyl, parathion, parathion-methyl, porata, phosmet, profenofos and trichlorfon. In yet another embodiment, organophosphate insecticide is a chlorpyrifos-methyl.

In one embodiment, the method of regulation of insect stage includes applying microencapsulating preparation of insecticide, in which the capsule shell is formed by interfacial polycondensation between at least one oil-soluble monomer selected from the group consisting of diisocyanates, polyisocyanates, acid chlorides of decislon, acid chlorides of PolicyKit, sulphonylchloride and chloroformiate, and at least one water-soluble monomer selected from the group consisting of diamines, polyamines, water soluble diols and water-soluble polyols, and the polycondensation is carried out in the presence of esterified fatty acids, having the formula A, where a represents:

where R1represents an alkyl or alkenylphenol group c straight or branched chain, having from 11 to 25 carbon atoms, and

R2represents an alkyl or alkenylphenol group c straight or branched chain, having from 1 to 8 carbon atoms.

In one embodiment, assests is of the product includes from about 3 to about 30% of the mass. esterified fatty acids. Another option exercise is a way to control the insect population on the land adjacent to the insect population, over an extended period of time after application of insecticidal preparation, including the next stage: providing microencapsulating insecticidal agent, which contains esterified fatty acid according to the formula A, wherein said drug continues to destroy or repel insects for at least 120 days after application. Another option exercise is a way to control the population of insects in this area, which includes the stage of applying microencapsulating insecticidal preparation, in which the microcapsule has a shell thickness of about 90 nm to about 150 nm, and applying microencapsulating of the drug on the plot adjacent to the insect population. In yet another embodiment, the shell or wall of the microcapsules has a thickness of about 120 nm.

In one embodiment of the present invention the polymer shell prolonged insecticidal preparation formed by cross-linking water-soluble monomer and the monomer is insoluble in water, in the presence of an amine, such as Diethylenetriamine, presets the following organophosphate insecticide and esterified fatty acids.

Another possible implementation is microencapsulating insecticidal product containing chlorpyrifos-methyl, methyl oleate and the polymer shell microcapsules containing a polyurea.

Detailed description

To facilitate understanding of the principles of the new technology this section provides the preferred options for its implementation with the use of special terminology to describe it. However, it should be understood that, without any limitations of the new technology is expected such changes, modifications, and additional applications of the principles of the new technologies that can perform expert in the technical field relates to a new method.

The terms "membrane" and "wall"used in this description in respect of the microcapsules, are used interchangeably, unless otherwise noted. These terms do not mean that the shell or wall necessarily completely homogeneous or that it completely covers the materials or components located inside the respective capsules, whatever they were.

The term "about" means the range of values plus or minus 20%, for example, the expression "approximately 1,0" includes values from 0.8 to 1.2 and all values within this range.

The need to periodically re-apply the many insecticidal preparations for regulating the ongoing intrusion of pests, or to prevent their occurrence leads to an increase in the number of insecticides, you need to use, and costs associated with shipping, handling and application. Unfortunately, most of insecticides, especially drugs on a liquid basis, lose its effectiveness soon after application, and for the regulation of insect populations, these drugs need to reapply. In accordance with these methods of obtaining drugs, insecticides, extending their effective action, be very beneficial for those industries and individuals that depend on the regulation of populations of insects.

Ways to extend the period of activity of insecticides after their applications include providing a powder or crystalline form of the active ingredients and their application to the areas adjacent to the insect, or areas susceptible to invasion by insects. Not all useful insecticides suitable for these applications, and some very useful insecticides are most effective in liquid or fluid form. Even when the connection is actively in crystalline or powdered form, there are situations in which dry drugs have their own restrictions, which include an increased tendency to accidental dispersal by wind or rain, or falling to the ground with a variety of raised surfaces, such to the to the leaves, stems and flowering parts of plants, where the specified connection can demonstrate the greatest usefulness. Another approach is the encapsulation of the active ingredient in the drug, intended to some extent to protect the active ingredient from drying, dilution and/or unwanted scattering. But in this case, many of the currently available encapsulated drugs of various insecticides still lose activity soon after their deposition on land adjacent to a population of insects.

Different ways of obtaining and applying microencapsulating insecticidal preparations disclosed in the present description, satisfy this need due to the fact that the drug they are at least partially encapsulate the active insecticide in the microcapsule together with non-volatile compound, such as esterified fatty acid. One group of insecticides, which positively affects their introduction to drugs such types are organophosphates. This class of insecticides include, but are not limited to, Arafat, azinphos-methyl, Chlorfenvinphos, chlorethoxyfos, chlorpyrifos, diazinon, dimethoate, disulfoton, ethoprophos, fenitrothion, fenthion, fenamiphos, fosthiazate, Malathion, methamidophos, methidathion, omethoate, oxydemeton-methyl, parathion, parathion-methyl, oral, phosmet, profenofos and trichlorfon. One particularly useful organophosphate insecticide, which has a positive effect on the inclusion in microencapsulating preparation containing a non-volatile component is chlorpyrifos-methyl.

As illustrated in table 1, the preparations of such insecticides like chlorpyrifos-methyl, can be enclosed in microcapsules through education of the capsules in the presence of an inert liquid, such as esterified fatty acid, soybean oil or polyglycol. The methods presented in the experimental part of the present description, were synthesized various preparations made with methyl oleate or without it.

Drugs organophosphate insecticides, such as microencapsulating the chlorpyrifos-methyl, after applying typically lose their activity.

Table 1
Compositions of representative drugs in the calculation of the ingredients used for the manufacture of microcapsules
The batch numberABCDEF
The desired diameter of the capsule (m) 121212121212
The desired wall thickness of the capsules (nm)1208012080120120
The chlorpyrifos-methyl (g)480486,6796,4897,8296,4896,48
1 Nonanal (g)9,69,731,931,961,931,93
Solvesso 150 (g)470,4476,9394,5595,8694,5594,55
The methyl oleate (g)--95,0496,36--
With Evoe oil (g) ----95,04-
Polyglycol P-2000 (g)-----95,04
PAPI 27 (g)40,0026,6712,008,0012,0012,00
Diethylenetriamine (g)10,99-3,30-3,303,30
The Ethylenediamine (g)-6,40-1,92
Gohsenol GL03 (g)25,0025,007,507,507,507,50

Veegum (g)13,0013,003,903,903,903,90
Kelzan S (g)1,621,620,490,490,490,49
Atlox 4913 (g)13,9113,914,174,174,174,17
Water (g)1087,481130,06317,80305,40317,80317,80
The measured diameter of the capsule (m)11,311,811,411,812,2the 11.6

Notes to the trade names and abbreviations used in table 1.

Solvesso 150 aromatic solvent xiaobao type, Exxon

Polyglycol P-2000 - poly(propylene glycol), DowChemical

PAPI 27 - polymethylene-polyphenylisocyanate, Dow Chemical

Gohsenol GL03 - polyvinyl alcohol, Nippon Gohsei

Veegum is a bentonite clay, R. T. Vanderbilt

Kelzan S - xanthan gum, Kelco

Atlox 4913 - polymer surfactant, Croda

Referring now to table 2, it should be noted that there were determined the size of the microcapsules and to them were given single-letter codes. In addition, to measure the effectiveness of these drugs then sprayed on the surface adjacent to the insect.

Table 2
Microcapsules of the chlorpyrifos-methyl, obtained with non-volatile solvents and without them
Code medicationSolventsAminParticle size (VMD m)Wall thickness (nm)
ASolvesso 150DETA12120
BSolvesso 150EDA1280
Cthe methyl oleate, Solvesso 150DETA 12120
Dthe methyl oleate, Solvesso 150EDA1280
Esoybean oil, Solvesso 150DETA12120

Hsoybean oil, Solvesso 150EDA1280
Fpolyglycol P-2000, Solvesso 150DETA12120
Ipolyglycol P-2000, Solvesso 150EDA1280

Qualitative characteristics of some components microencapsulating preparations insecticides, formed with an inert non-volatile components, such as soybean oil, polyglycol or esterified fatty acids, or without them.

Table 3
Application data pre is Arata, including the dilution of the drug prior to its application and rate of application of the drug is used for testing of different drugs on different surfaces
Code medicationProduct (g/l) C-MThe amount of sample added to water (ml)Rate of application (ml/m2)
A2404,17 in 45,8350 ml
B2404,17 in 45,83
C1506,67 in 43,33
D1506,67 in 43,33
E1506,67 in 43,33
F1506,67 in 43,33
G750 g/kg2,68 g was added to 50 ml
Untreated control--

To test the effectiveness microinch polirovannyj drugs disclosed in the present description, the drugs with the reference drugs were applied to the surface of plaster, wood and clay. The activity of the preparations was subjected to monitoring with the reference drugs against the mosquito species Anopheles arabiensis. Research conducted during the 170-day period; the data collected in these tests are presented in tables 4-8, their synthesis is given in table 9.

td align="center" morerows="7"> Tree
Table 4
The results of determining the mortality of Anopheles arabiensis
Post-processingThe test surfaceThe code sampleThe number of paralyzed individuals 15The number of dead individuals from 15
Re-calculations after 30 minA total of 60Re counts after 24 hA total of 60
1234123 4
1 dayGypsumA2431101515151560
B11131210461515151560
C4979291515151560
D1415141356151515 1560
E4536181515151560
F14141514571515151560
G12131116511515151560
Control-----10034
A109287341515151560
B12131115511515151560
C89710341515151560
D12131314521515151560
E 14101211471515151560
F15141515591515151560
G10131110441515151560
Control-----01113
1 dayClay A2431101515151560
B11131210461515151560
C4979291515151560
D14161413561515151560
E4 536181515151560
F14141514571515151560
G12131115511515151560
Control-----10034

The results of determining the mortality of Anopheles arabiensis defined after 1 day after application of the drug on the surface is to be pests.

td align="center"> 0
Table 5
The results of determining the mortality of Anopheles arabiensis
Post-processingThe test surfaceThe code sampleThe number of paralyzed individuals 15The number of dead individuals from 15
Re-calculations after 30 minA total of 60Re counts after 24 hA total of 60
12341234
1 monthGypsumA0000015151515 60
B000001515151560
C000001515151560
D203161515151560
E000001515151560
F 000001515151560
G212271515151560
Control-----02125
TreeA000001515151560
B00001515151560
C000001515151560
D3542141515151560
E000001515151560
F000 001515151560
G000001515151560
Control-----11136
1 monthClayA0000013157944
B00 0006159434
C00000156151551
D00000732012
E00000613151246
F00000 1010011
G000001514121556
Control-----00123

The results of determining the mortality of Anopheles arabiensis defined through 1 month after drug application to the surface of pests.

td align="center"> 0
Table 6
The results of determining the mortality of Anopheles arabiensis
Post-processingThe test surfaceThe code sampleThe number of paralyzed person is from 15 The number of dead individuals from 15
Re-calculations after 30 minA total of 60Re counts after 24 hA total of 60
12341234
2 monthsGypsumA000001515151560
B000001515151560
C0 00001515151560
D203161515151560
E000001515151560
F000001515151560
G212 271515151560
Control10113
TreeA000001515151560
B000001515151560
C00001515151560
D3542141515151560
E000001515151560
F000001515151560
G0000015 15151560
Control02103
2 monthsClayA0000091591245
C000001112151351
E00000 89151547
G00000131091345
Control02125

The results of determining the mortality of Anopheles arabiensis, some 2 months after drug application to the surface of pests.

2
Table 7
The results of determining the mortality of Anopheles arabiensis
Post-processingThe test surfaceThe code sampleThe number of paralyzed individuals 15 The number of dead individuals from 15
Re-calculations after 30 minA total of 60Re counts after 24 hA total of 60
12341234
A000001412131049
B000001515151560
C000/td> 001515151560
4 monthsGypsumD20316374518
E000008105932
F000001014101347
G21271515151560
Control-----01113
TreeA00000325313
B000001515151560
C000 001515151560
D00000142310
E000004116829
F00000216312
G000001 14141558
Control-----01012
4 monthsClayA00000233715
C00000864321
E0000 23218
G000007115831
Control0000022015

The results of determining the mortality of Anopheles arabiensis, some 4 months after drug application to the surface of pests.

Table 8
The results of determining the mortality of Anopheles arabiensis
Post-processingThe test surfaceThe code sampleThe number of paralyzed individuals is C 15 The number of dead individuals from 15
Re-calculations after 30 minA total of 60Re counts after 24 hA total of 60
12341234
5 months and 3 weeksGypsumA0000097111037
B0000010691338
C 000001515151560
F0000033219
G000001515151560
Control-----10214
TreeA0 0000598628
B000001415151559
C00000151151560
G000001514151559
Control--- --10102
5 months and 3 weeksClayA00000412310
B00000371213
C00000586423
Control00 00001135

The results of determining the mortality of Anopheles arabiensis defined in 5 months and 3 weeks after application of the drug on the surface of pests.

The summation of the results of measurements of residual insecticidal activity conducted on the mosquitoes. These values were determined after the application of different microencapsulating drugs, containing organophosphate insecticide such as chlorpyrifos-methyl. Some of the drugs contained esterified fatty acid, although other preparations did not contain this compound.

Referring now to table 9, it should be noted that of all the tested drugs are the most effective long periods of activity after the application had drugs, containing esterified fatty acids. Other non-volatile components, such as soybean oil and polyglycol, not extended effective field term insecticide to the same extent as did esterified fatty acids. The results demonstrate that adding Eteri tirovannoj fatty acids to the microcapsule, which contains organophosphate insecticide creates microencapsulating the drug retains its insecticidal activity to 150 days after application.

Experimental part

Materials and methods

The suspensions of microcapsules

Referring now to table 1, it should be noted that it shows the number of all components used for the synthesis of representative suspensions of capsules. The methodology that was followed to obtain the compounds listed in table 1 was as follows. Various preparations were made by changing the composition of the reaction mixture. The organic phase was obtained by mixing the specified amount of isocyanate monomer PAPI 27 (Dow Chemical) with 50%of the mass. a solution of chlorpyrifos-methyl in Solvesso 150, containing also 1 nonanal as preservative. The methyl oleate, soybean oil or polyglycol P-2000 was introduced, as shown in table 1. The mixture was stirred until homogeneity. Got the aqueous phase, containing given amounts of polyvinyl alcohol (PVA, Gohsenol GL03, Nippon Gohsei), Veegum(R. T. Vanderbilt) and Kelzan S (Kelco) as indicated in table 1 by the number of deionized (DI) water except its number, which is used to prepare a 10%aqueous solution of amine, described below. The aqueous phase was added to the organic phase to obtain a two-phase mixture. Obtained from the ect was mulgirigala, using a high-speed mixer Silverson L4RT-A standard mixing head, collected with an emulsion sieve. Emulsification was carried out by first mixing at relatively low speed (~1000 rpm) to achieve complete emulsification, placing the tip of the injector head in the aqueous phase, to guide her in the organic phase. Then the speed was increased in discrete parsimonies. After each level increases the speed and determination of particle size the mixer was stopped. This process is continued until the desired particle size. Usually to achieve the desired size of the required speed ~4500-7500 rpm Cross-linking amine (Diethylenetriamine (DETA) or Ethylenediamine (EDA), Aldrich), was added dropwise in the form of a 10%aqueous solution under stirring at a reduced speed, supporting good mixing. After adding the amine resulting from the suspension of capsules was stirred for an additional minutes, added the specified number of Atlox 4913 and have a little final homogenization to complete the process of obtaining a suspension of capsules.

By carefully adjusting the duration of the mixing process and/or by adjusting the speed of the mixer can produce encapsulated organophosphate insecticidal preparations to maintain the AMI of various sizes, with different shell thickness. Similarly, to create microencapsulating organophosphate insecticide with different capsules with shells of different thickness, it is possible to regulate the quantity of monomer, cross-linking agents, humectants, buffers, etc.

The final composition of microcapsules equivalent to or almost identical to the relative proportions of the materials used for their formation. Accordingly, the composition of these drugs are very similar, if not identical, to the composition of the reaction mixtures used for their education (table 1).

Measurement of particle size in suspensions of microcapsules

The distribution of particle size in suspensions of capsules was determined on the device for the determination of particle size on scattering Malvern Mastersizer 2000 with a cell for samples of small volumes using software version 5.12. Before measurement, the samples were shaken or thoroughly mixed to ensure homogeneity. For each drug listed above in the "Materials"section, shows the distribution of average (median) volume (volume median distribution, VMD).

Calculation of wall thickness capsules

The calculation of the number of components of the walls of capsules needed to obtain the desired wall thickness, were based on the geometric formula relations the volume of the mA of the sphere to its radius. Assuming such a morphology of the shell and the core in which the core contains insoluble components are not able to form wall (chlorpyrifos, solvent), and the membrane formed from the polymerized materials (oil - and water-soluble monomers), then fairly equation (1)connecting ratio of total volume of core (Vc) and the volume of the shell (Vs) to the volume of the core with their respective radii, where rsrepresents the radius of the capsule, including the shell, and lsrepresents the thickness of the shell:

The transformation of equation (1) for the volume of the shell gives the following expression:

Substitution mass (mi) and density (diinstead of their respective volumes (ms/ds=Vsand mc/dc=Vcwhere the subscript "s" or "c" refers to the shell or the core (core), respectively), and the transformation of this equation for the mass shell, network:

The assumption that the ratio of densities of the ds/dcapproximately one adopted to simplify the calculation, and the direct use of the respective masses of the components of the core and the shell of the capsule, has led to equation (4):

Postano the Ki m c=mO-mOSM, ms=mO+(fWSM/OSM))mOSM-mcand fWSM/OSM=mWSM/mOSM(the ratio of water-soluble monomer to the oil-soluble monomer), where mOrepresents the total weight of the oily component (chlorpyrifos, solvent, oil-soluble monomer), mOSMrepresents the mass of the oil-soluble monomer, and mWSMrepresents the mass of the water-soluble monomer, and the transformation for mOSMgives:

When determining the mOSMfor convenience in the calculations used the total number of mWSM. In the present study for all drugs suspensions of capsules used the ratio of the equivalent mass of water-soluble monomer and an oil-soluble monomer is 1:1.

List of various synthesized and tested products; also see table 1

A contains 22.4% wt./mass. (240 g/l) chlorpyrifos-methyl.

B contains 22.4% wt./mass. (240 g/l) chlorpyrifos-methyl.

C contains a 14.6% wt./mass. (150 g/l) chlorpyrifos-methyl.

D contains a 14.6% wt./mass. (150 g/l) chlorpyrifos-methyl.

E contains a 14.6% wt./mass. (150 g/l) chlorpyrifos-methyl.

F contains a 14.6% wt./mass. (150 g/l) chlorpyrifos-methyl.

DDT-G contains 750 g/kg trichloro(chlorophenyl)ethane.

Testing methods

Tests for insecticidal knockdown etc who were taken using a modified version of the laboratory Protocol WHO. In these tests, as the test insects used female mosquitoes aged 1-5 days. As the test surfaces used clay from Nduma, Tanzania, wood and plaster. The clay used in these tests was from the same source of the clay used to build some primitive dwellings in Nduma. Clay plates were made by mixing the soil and tap water and placing the mixture in a plastic form. The surface is made flat and the plate was left to dry. The formed fractures filled with clay. Gypsum plates were made by mixing the gypsum with tap water, using the same or essentially the same form as used for manufacturing test clay surfaces. Samples of various drugs were diluted with tap water in the ratios shown in table 3, and inflicted gun-spray aerographics type.

Plaster and wooden plates were sprayed and the next day there was the first session of exposure. Testing effects on insects was repeated, using the same surface, at the following intervals: one month, two months, four months and five months and 3 weeks (approximately 170 days). In connection with the duration of the test and limited availability of female mosquitoes aged 1-5 days this t the article was divided into two series.

When applying each sample was also processed eight sheets of filter paper. These sheets were placed in a low temperature refrigerator at -27C for analysis at the end of the following periods after treatment: one day, one month, two months, four months and five months and three weeks. After each session effects were calculated paralyzed individuals and endured mosquitoes in glass containers. Glass containers covered with gauze (organdy), secured with an elastic band. On top of the gauze was placed a piece of cotton wool soaked in 5%sugar solution as feed. Repeated sessions of exposure was carried out on those surfaces where the mortality obtained in the previous session exposure exceeded 70%, or wherever it was deemed necessary in the course of conducting these experiments.

Additional features and advantages of the present invention will be described in the subsequent application and will partly be obvious to experts in the art from the present description or recognized on the basis of the practical application of the present invention, as described in the present description, including a description of the subsequent application, the claims and the attached drawings.

Although new technology is illustrated and described in detail in the subsequent description stated the key using figures and the previous descriptions, it should be considered as illustrative and no restrictive, and it should be understood that the shown and described only the preferred embodiments of the present invention and that all changes and modifications which do not depart from the substance of the present invention, should also be included in the scope of protection. In addition, although new technology is illustrated with concrete examples, theoretical arguments, calculations and illustrations these illustrations and the accompanying discussion in no way should be interpreted as limiting the present invention. All patents, patent applications and references to the texts, scientific papers, publications, etc. given in this description are included in the present description in its entirety by reference.

1. The method of producing drug microencapsulating insecticide, which includes stages:
providing at least one insecticide, at least one esterified fatty acid, where the esterified fatty acid is a methyl oleate at least one cross-linking agent and at least one type of monomer;
mixing insecticide, esterified fatty acid, at least one cross-linking agent and at least the underwater type monomer; and
the formation of the polymer shell microcapsules, which at least partially encapsulates a portion of the insecticide and part of esterified fatty acids, forming microencapsulating insecticidal drug where microencapsulating insecticidal drug retains its ability to control insects for at least 120 days after drug application to the area adjacent to the insect population.

2. The method according to claim 1, where the insecticide is organophosphate insecticide.

3. The method according to claim 2, where organophosphate insecticide selected from the group consisting of acetate, azinphos-methyl, Chlorfenvinphos, chlorethoxyfos, chlorpyrifos, diazinon, dimethoate, disulfoton, ethoprophos, fenitrothion, sanitary legislature, fenamiphos, fosthiazate, Malathion, methamidophos, methidathion, omethoate, oxydemeton-methyl, parathion, parathion-methyl, porata, phosmet, profenofos and trichlorfon.

4. The method according to claim 3, where organophosphate insecticide is chlorpyrifos-methyl.

5. The method according to claim 1, where the polymer shell is formed by interfacial polycondensation, and at least one type of monomer includes:
at least one oil-soluble monomer selected from the group consisting of diisocyanates, polyisocyanates, acid chlorides of decislon, acid chlorides of PolicyKit, sulphonylchloride and is of lahorites; and
at least one cross-linking agent selected from the group consisting of diamines, polyamines, water soluble diols and water soluble polyols.

6. The method according to claim 1, where the shell of the microcapsules has a thickness of from about 90 to about 150 nm.

7. The method according to claim 1, where the shell of the microcapsules has a thickness of about 120 nm.

8. The method according to claim 5, where the cross-linking agent is Diethylenetriamine.

9. The method of regulation of the insect population, which includes stages:
providing microencapsulating insecticide according to claim 1, containing:
at least one esterified fatty acid, where this acid is a methyl oleate;
at least one organophosphate insecticide and a polymer shell microcapsules, which at least partially encapsulates the insecticide and esterified fatty acid; and
applying microencapsulating of the drug on the plot adjacent to the insect population, where microencapsulating the drug retains its insecticidal activity for at least 120 days after application on a site adjacent to the insect population.

10. The method according to claim 9, where organophosphate insecticide selected from the group consisting of acetate, azinphos-methyl, Chlorfenvinphos, chlorethoxyfos, chlorpyrifos, diazinon, dimethoate, dis is hoton, ethoprophos, fenitrothion, sanitary legislature, fenamiphos, fosthiazate, Malathion, methamidophos, methidathion, omethoate, oxydemeton-methyl, parathion, parathion-methyl, porata, phosmet, profenofos and trichlorfon.

11. The method according to claim 9, where organophosphate insecticide is chlorpyrifos-methyl.

12. The method according to claim 9, where the wall of the capsule is formed by interfacial polycondensation of at least one oil-soluble monomer selected from the group consisting of diisocyanates, polyisocyanates, acid chlorides of decislon, acid chlorides of PolicyKit, sulphonylchloride and CHLOROFORMATES; and at least one water-soluble monomer selected from the group consisting of diamines, polyamines, water soluble diols and water soluble polyols.

13. The method according to claim 9, where the cross-linking agent is Diethylenetriamine.

14. The method of claim 8, where the wall of the microcapsules has a thickness of from about 90 nm to about 150 nm.

15. The method of claim 8, where the wall of the microcapsules has a thickness of about 120 nm.

16. Microencapsulating insecticidal preparation containing:
the chlorpyrifos-methyl,
the methyl oleate and
shell microcapsules containing a polyurea.



 

Same patents:

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. The compound is selected from a group including formula 1, formula 2, formula 3, formula 4, formula 5 and formula 6. Formula 1 is , where R1 = isobutyl, sec-butyl or tert-butyl-CH2; R2=H; n=0-25. Formula 2 is , where R1 = sec-butyl or tert-butyl-CH2; R2=H. Formula 3 is , where R1 = isobutyl, sec-butyl or tert-butyl-CH2; R2=H. Formula 4 is , where R1 = isobutyl; R2=H; R3 = n-alkyl containing 2-25 carbon atoms, except n-heptyl and n-undecyl, branched alkyl containing 4-25 carbon atoms, substituted or unsubstituted cycloalkyl containing 3-25 carbon atoms, or substituted or unsubstituted arylalkyl containing 12-26 carbon atoms; or R1 = sec-butyl or tert-butyl-CH2; R2=H; R3 = n-alkyl containing 1-25 carbon atoms, branched alkyl containing 3-25 carbon atoms, substituted or unsubstituted cycloalkyl containing 7-25 carbon atoms, or substituted or unsubstituted arylalkyl containing 7-25 carbon atoms; or R1 = isobutyl; R2 = methyl; R3 = n-alkyl, containing 2, 3, 6 and 12-25 carbon atoms, branched alkyl containing 3-25 carbon atoms, substituted or unsubstituted cycloalkyl containing 3-25 carbon atoms, or substituted or unsubstituted arylalkyl containing 7-25 carbon atoms. Formula 5 is , where R4=H, alkyl, haloalkyl, alkoxy, alkylthio, haloalkoxy or haloalkythio, each containing 1-4 carbon atoms, or halogen, hydroxyl group, nitro group, carboxylic acid group or cyano group; an either R1 = sec-butyl or tert-butyl-CH2; and R2=H; or R1 = isobutyl; and R2 = methyl; and formula 6 is , where R4 = H, alkyl, haloalkyl, alkoxy, alkythio, haloalkoxy, haloalkylthio, each containing 1-4 carbon atoms, or halogen, hydroxyl group, nitro group; carboxylic acid group or cyano group; and either R1 = isobutyl, sec-butyl or tert-butyl-CH2; R2=H; or R1 = isobutyl; and R2 = methyl. Said compounds are used to attract zoospores of plant pathogenic oomycetes of fungi or control plant diseases.

EFFECT: invention increases treatment efficiency.

17 cl, 2 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. The fungicidal composition contains tolclofos-methyl, polyoxyethylene polyaryl phenol phosphate, a polyoxyethylene and polyoxypropylene block-copolymer, a polyoxyethylene ester of a fatty alcohol and water.

EFFECT: invention improves stability of the composition at high temperature.

6 cl, 2 tbl, 4 ex

FIELD: chemistry.

SUBSTANCE: invention relates to halogen-6-(aryl)-4-iminotetrahydropicolinic acids of formula I, where R represents -OS(O)2R1 or -OC(O)R1; R1 represents C1-C4-alkyl or phenyl, substituted with C1-C4-alkyl; R2 represents C1-C4-alkyl; Q represents Cl or Br; W represents H, F or Cl; X represents H or C1-C4-alkoxygroup; Y represents a halogen atom; and Z represents H or F. The invention also relates to herbicidal compositions based on the claimed formula (I) compound.

EFFECT: obtained are novel compounds and based on them herbicidal compositions, which can be applied in agriculture for the suppression of undesirable vegetation.

4 cl, 3 tbl, 19 ex

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. Fungicidal composition contains: A) copper salicylate, which has the following molecular formula C7H4O3Cu(H2O) (I), where n represents 0, 1, 2 or 3; B) copper hydroxide Cu(OH)2 (II); C) copper salt, which has the following formula 3Cu(OH)2X(Y)m (III), where: X represents copper ion Cu2+; Y stands for chloride-ion Cl-; m represents integer number, equal 2; possibly in presence of dispersants, diluents, surface-active substances and/or agronomically acceptable coformulants.

EFFECT: invention makes it possible to increase composition and preparation activity.

10 cl, 1 tbl, 12 ex

FIELD: agriculture.

SUBSTANCE: rodenticide composition comprises the active ingredient - poison of acute action, the gelling agent, the dye. As the poison of acute action it comprises zinc phosphide or glyfluor or monofluoride or fluoroacetamide, or barium fluoroacetate, additionally as gelling agent it comprises a mixture of xanthan and carob gum, taken in weight ratio equal to (1-9):(1-9), respectively, or a mixture of carrageenan and carob gum, taken in weight ratio equal to (1-9):(1-9), respectively, or a mixture of xanthan and guar gum, taken in weight ratio equal to (1-9):(1-9), respectively, also comprises water, or milk, or milk whey in the following ratio, wt %: poison of acute action 0.5-5.0; mixture of xanthan and carob gum, taken in weight ratio equal to (1-9): (1-9), respectively, or a mixture of carrageenan and carob gum, taken in weight ratio equal to (1-9):(1-9), respectively, or a mixture of xanthan and guar gum, taken in weight ratio equal to (1-9):(1-9), respectively, 0.3-15; dye 0.02-0.05; water, or milk, or milk whey - the rest.

EFFECT: invention enables to use the composition in subzero temperatures.

7 cl, 331 ex

FIELD: agriculture.

SUBSTANCE: invention relates to agriculture. For controlling the agricultural crop induced with pathogen of disease, the identification of one or several plants is carried out, with the risk of development of the disease from the pathogen resistant to Qo inhibitor, and contacting of the said one or several plants with a composition comprising an effective amount of Qi inhibitor.

EFFECT: invention enables to implement the specified assignment.

14 cl, 3 tbl, 2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. Fungicidal composition contains:

A) tetrazolyloxime derivative of formula ,

where A represents tetrazoyl group of formula ,

where Y represents alkyl group; and - Het represents pyridyl group of formula ,

where Z represents group of formula QC(=O)NH-, where Q. represents alkoxyl group, having from 1 to 8 carbon atoms; and B) fungicidal compound, selected from the list, consisting of bixafen, boscalid, azoxystrobin, fluoxastrobin, pyraclostrobin, trifloxystrobin, fluazinam, fludioxonil, iprodione, propamocarb, propamocarb hydrocloride, prothiocozanole, tebuconazole, iprovalicarb, chlorothalonil, mancozeb, propineb, N-[2-(1,3-dimethylbutyl)phenyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide, cymoxanil, fosetyl aliminium, fosetyl calcium, fosetyl sodium and propamocarb fosetylate, with weigh ratio A/B in the range from 1/0,01 to 1/100 Application of agronomically efficient and in fact non-phytotoxic quantity of said composition is carried out to treat seeds, apply on leaves, and apply on stems and trunks.

EFFECT: invention makes it possible to increase treatment efficiency.

20 cl, 6 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. The high-viscosity oil-based agrochemical composition includes (a) biocides, (b) hydrophobic carriers and (c) polymers selected from a group consisting of poly(meth)acrylates, polymaleates and polyfumarates.

EFFECT: invention increases viscosity of the composition.

14 cl, 3 tbl, 3 ex, 1 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. A composition for stabilising an agriculturally active compound contains an oil-in-water emulsion which includes an oil phase and an aqueous phase. The oil-in-water emulsion contains sodium chloride, at least one agriculturally active compound, at least one nonionic lipophilic surfactant having hydrophilic-lipophilic balance in the range of 2 to 5, at least one nonionic hydrophilic surfactant having hydrophilic-lipophilic balance in the range of 8 to 12, at least one ionic surfactant and at least polymeric surfactant. The composition is deposited on fungi, soil, plants, seeds and an insect, weed, bacteria, rodent and termite control area.

EFFECT: invention increases stability of agriculturally active compounds.

26 cl, 6 tbl, 3 ex

FIELD: chemistry.

SUBSTANCE: invention relates to biocides. The synergetic antimicrobial composition contains: (a) a hydroxymethyl-substituted phosphorus compound, which is a tetrakis(hydroxymethyl)phosphonium salt, and (b) a second biocide selected from a group comprising (1) hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine, (2) 2,6-dimethyl-1,3-dioxan-4-ylacetate and (3) ortho-phenylphenol or alkali metal salts or ammonium salts thereof. The weight ratio of the hydroxymethyl-substituted phosphorus compound to hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine ranges from 15:1 to 1:15. The weight ratio of the hydroxymethyl-substituted phosphorus to 2,6-dimethyl-1,3-dioxan-4-ylacetate ranges from 15:1 to 1:15. The weight ratio of hydroxymethyl-substituted phosphorus compound to ortho-phenylphenol or alkali metal salts or ammonium salts thereof ranges from 15:1 to 1:5.

EFFECT: invention increases effectiveness of the composition.

7 cl, 6 tbl, 6 ex

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. The pesticide composition contains a synergetically effective amount of at least one anthranyl amide compound or salt thereof, and another pesticide. The anthranyl amide compound is N-[2-bromo-4-chloro-6-[[(cyclopropylmethyl)amino]carbonyl]-phenyl]-3-bromo-1-(3-chloro-2-pyridyl)-1H-pyrazole-5-carboxamide.

EFFECT: invention enables to increase efficiency of pest control.

16 cl, 51 tbl, 6 ex

The invention relates to the derivatives of aminothiophene F.-ly (R1O)(R2S)P(O)-N[(CH2)nCN] C(O)R3(II) where R1is methyl or ethyl; R2- n-propyl or sec-butyl; R3- (C1- C4-alkoxygroup; (C1- C4-allylthiourea, phenyl, phenoxy; n = 1 or 2, which are active in the fight against harmful insects, nematodes and mites at low acute toxicity towards mammals

The invention relates to compounds having the structural formula I, where X, Y, R and Z are defined in the description of the application

The invention relates to the field of organic chemistry, in particular 4-phenyl-4-diisopropylphenyl-3-diisopropylamino - fan formula

(i-C3H70)OC3H7-i , (1) with astragalina activity on the sunflower

The invention relates to the derivatives of aminothiophene F.-ly (R1O)(R2S)P(O)-N[(CH2)nCN] C(O)R3(II) where R1is methyl or ethyl; R2- n-propyl or sec-butyl; R3- (C1- C4-alkoxygroup; (C1- C4-allylthiourea, phenyl, phenoxy; n = 1 or 2, which are active in the fight against harmful insects, nematodes and mites at low acute toxicity towards mammals

The invention relates to the field of organic chemistry, in particular, butyl ether, 4-isopropyl-4-diethylthiophosphoryl acid formula

(C2H5O)NH-OC4H9-H , (1) with insecticide and acaricide activity

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. Agronomical composition includes (a) biocides and (b) products of alkoxylation of esters of di- or oligosaccharides.

EFFECT: invention makes it possible to increase composition stability.

11 cl, 4 tbl, 6 ex, 2 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to biocides. A synergic antimicrobial composition contains: (a) hydroxymethyl-substituted phosphorus-containing compound, which represents tetrakis(hydroxymethyl)phosphonium salt; and (b) cis-1-(3-chloroallyl)-3,5,7-triaza-1-azonium-adamantane chloride. A weight ratio of (a) and (b) in the composition constitutes from 15:1 to 1:15. To inhibit growth of microorganisms in a medium, which has a temperature at least 60C and content of sulphides at least 4 ppm, the said composition is added.

EFFECT: invention makes it possible to increase the composition activity.

10 cl, 2 tbl, 1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. A pesticidal preparation contains a pesticide and a polymer fraction. The polymer fraction contains at least approximately 60 wt % of copolymer of maleic/itaconic acids, including fragments of maleic acid and itaconic acid. The total weight of the said polymer fraction constitutes 100 wt %.

EFFECT: invention makes it possible to increase the preparation efficiency.

30 cl, 3 tbl, 3 ex

FIELD: chemistry.

SUBSTANCE: invention relates to biocides. Biocidal composition contains gluteraldehide and biocidal oxazolidine compound. To realise control over microorganisms in water or water-containing system in the process of oil or gas extraction the system is processed with composition, containing gluteraldehide and biocidal oxazolidine compound. Oxazolidine compound represents 4,4-dimethyloxazolidine. Weight ratio of gluteraldehide to 4,4-dimethyloxazolidine is in the range from 6:1 to 1:9. Oxazolidine compound represents 7-ethylbicyclooxazolidine. Weight ratio of gluteraldehide to 7-ethylbicyclooxazolidine is in the range from 20:1 to 1:20. Water or water-containing system contains sulfides. Microorganisms to be eliminated represent sulfate-reducing bacteria.

EFFECT: invention makes it possible to increase efficiency of control over microorganisms in water or water-containing systems, such as systems, detected in the process of oil or natural gas extraction.

3 cl, 7 tbl, 3 ex

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