Acyl hydrazones and semicarbazones, composition based thereon, zoospore, method of controlling oomycetes of false pathogenic fungus (versions) and plant disease control method

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. The compound is selected from a group including formula 1, formula 2, formula 3, formula 4, formula 5 and formula 6. Formula 1 is , where R1 = isobutyl, sec-butyl or tert-butyl-CH2; R2=H; n=0-25. Formula 2 is , where R1 = sec-butyl or tert-butyl-CH2; R2=H. Formula 3 is , where R1 = isobutyl, sec-butyl or tert-butyl-CH2; R2=H. Formula 4 is , where R1 = isobutyl; R2=H; R3 = n-alkyl containing 2-25 carbon atoms, except n-heptyl and n-undecyl, branched alkyl containing 4-25 carbon atoms, substituted or unsubstituted cycloalkyl containing 3-25 carbon atoms, or substituted or unsubstituted arylalkyl containing 12-26 carbon atoms; or R1 = sec-butyl or tert-butyl-CH2; R2=H; R3 = n-alkyl containing 1-25 carbon atoms, branched alkyl containing 3-25 carbon atoms, substituted or unsubstituted cycloalkyl containing 7-25 carbon atoms, or substituted or unsubstituted arylalkyl containing 7-25 carbon atoms; or R1 = isobutyl; R2 = methyl; R3 = n-alkyl, containing 2, 3, 6 and 12-25 carbon atoms, branched alkyl containing 3-25 carbon atoms, substituted or unsubstituted cycloalkyl containing 3-25 carbon atoms, or substituted or unsubstituted arylalkyl containing 7-25 carbon atoms. Formula 5 is , where R4=H, alkyl, haloalkyl, alkoxy, alkylthio, haloalkoxy or haloalkythio, each containing 1-4 carbon atoms, or halogen, hydroxyl group, nitro group, carboxylic acid group or cyano group; an either R1 = sec-butyl or tert-butyl-CH2; and R2=H; or R1 = isobutyl; and R2 = methyl; and formula 6 is , where R4 = H, alkyl, haloalkyl, alkoxy, alkythio, haloalkoxy, haloalkylthio, each containing 1-4 carbon atoms, or halogen, hydroxyl group, nitro group; carboxylic acid group or cyano group; and either R1 = isobutyl, sec-butyl or tert-butyl-CH2; R2=H; or R1 = isobutyl; and R2 = methyl. Said compounds are used to attract zoospores of plant pathogenic oomycetes of fungi or control plant diseases.

EFFECT: invention increases treatment efficiency.

17 cl, 2 dwg

 

Various aspects disclosed herein relate to new compositions which release the attractant fungal zoospores, which may work well for the introduction of the drug with fungicides in various compositions that can be used in the methods of control of fungi.

The level of technology

Economically important plants can be exposed to a variety of plant pathogens. Many of the diseases that are the result of such influence, called oomycete the pseudo fungi. A large number of diseases caused by pathogenic oomycetes, such as late blight of potato or tomato, downy mildew of grapes or peronospora vegetables, can be particularly harmful.

The life cycle of many pathogenic oomycetes includes a number of spore forms, which are very important for the development and spread of these diseases. For example, during the vegetative life cycle of a number of oomycete pseudagrion, such as Phytophthora infestans, which causes late blight of potatoes, and Plasmopara viticola, which causes downy mildew of grapes, pathogenic fungus produces a fixed spores called sporangia. In suitable conditions, the contents of the sporangium produces new spores, called zoospores. Zoospores have flagella and are able to swim in the water, that is they are mobile. AOR is disputes act as the main agents of infection, floating and encapsulates about stomata of plants or other suitable spots on leaves, stems, roots, seeds or tubers to infect plants. After that, the foliage of the germ tubes from germinating cysts enter the stomata on the surface of a leaf or root or in some cases, the germ tube of the encapsulated zoospores can directly penetrate the surface of the leaf or root.

Scientists have identified various chemical substances that attract zoospores mushrooms. These attractants zoospores in General can be described as a substance or compound that induces a chemotactic response of zoospores. Some examples of chemical compounds that are attractants zoospores described in the article "Fatty acids, aldehydes and alcohols as attractants for zoospores of Phytophthora palmivora" (Nature, Volume 217, page 448; Cameron and Carlile). Other examples of attractants zoospores provided in the articles "Biology of Phytophthora zoospores" (Phytopathology, Volume 60, pages 1128-1135; Hickman) and Chemotactic response of zoospores of five species of Phytophthora" (Phytopathology, Volume 63, page 1511; Khew). The content of each of the above articles are included in this description in its entirety by reference.

Usually these chemical compounds or substances, constitutes attractants zoospores are produced root part of the plant and may increase infectious process in the rhizosphere, allowing zoospores discover sites DL the infection. It is possible that the foliage of plants or specific sites on the leaves also produce substances that are attractive to zoospores. The ability of substances to attract zoospores through chemotaxis was tested using various methods described in the literature, such as methods using capillary, which secrete a substance to be tested. Such standard methods are applicable and described in various publications, including the following publications:

1. Donaldson, S.P. and J.W. Deacon. 1993.New Phytologist, 123: 289-295.

2. Tyler, B.M., M-H. Wu, J-M. Wang, W. Cheung and P.F. Morris. 1996.Applied and Environmental Microbiology, 62: 2811-2817.

3. Khew, K.I. and G.A. Zentmeyer. 1973.Phytopathology, 63: 1511-1517.

Typically, compounds that are tested for their ability to attract zoospores through chemotaxis, must have sufficient solubility in water or, in the case of low solubility in water, they should be placed in a suitable physical form or matrix to provide sufficient release of the tested compounds. The researchers found that some natural aldehydes and ketones with short-chain (C4-C8) are powerful attractants zoospores. It was further shown that these aldehydes and ketones increase the effectiveness of fungicides, with a characteristic toxic effect on pathogenic oomycetes, when used in see the sea with them. However, the applicability of aldehydes and ketones with a short circuit in most cases limited to certain physical properties, such as high volatility or high solubility in water.

The present invention provides new methods and compositions of the control of plant pathogenic oomycete mushrooms. The composition according to the invention typically comprises a composition suitable for control oomycete fungi capable of producing zoospores, and this composition includes an agronomically effective amount of a fungicide and at least one derived attractant zoospores obtained from a molecule of aldehyde or ketone attractant zoospores with a short chain.

The INVENTION

One variant of the invention is a composition suitable for the attraction of zoospores oomycete mushrooms. A derivative is hydrolyzed in water in time with the release of attractant zoospores. An additional variant embodiment of the invention is a mixture derived attractants zoospores and agronomically effective amount of a fungicide effective against oomycete mushrooms.

Another variant implementation of the invention is a derivative of attractant zoospores, which on exposure in water releases of attract the t zoospores. These derived attractants are usually acylhydrazone or semicarbazone and include compounds selected from the group comprising the compounds of formula 1, formula 2, formula 3, formula 4, formula 5 and formula 6, where

formula 1 represents a

where R1= isobutyl, sec-butyl or tert-butyl-CH2; R2=H; n=0-25;

formula 2 represents a

where R1= sec-butyl or tert-butyl-CH2; and R2=H;

formula 3 represents

where R1= isobutyl, sec-butyl or tert-butyl-CH2; and R2=H;

formula 4 is a

where R1= isobutyl, R2=H; R3=n-alkyl containing 2-25 carbon atoms, except h-gateleg or n-underyling of Akilov, alkyl branched chain, containing 4-25 carbon atoms, substituted or unsubstituted cycloalkyl that contains 3-25 carbon atoms, substituted or unsubstituted arylalkyl containing 12-26 carbon atoms; or R1= sec-butyl or tert-butyl-CH2, R2=H and R3=n-alkyl containing 1-25 carbon atoms, branched alkyl containing 3-25 carbon atoms, substituted or unsubstituted cycloalkyl containing 7 to 25 carbon atoms, substituted or nezamedin the th arylalkyl, containing 7 to 25 carbon atoms; or R1= isobutyl, R2= methyl and R3= n-alkyl containing 2, 3, 6 and 12-25 carbon atoms, the alkyl branched chain, which contains 3-25 carbon atoms, substituted or unsubstituted cycloalkyl that contains 3-25 carbon atoms, or a substituted or unsubstituted arylalkyl containing 7-25 carbon atoms;

formula 5 represents a

where R4=H, alkyl, halogenated, alkoxy, alkylthio, halogenoalkane or allogeneically, each of which contains 1-4 carbon atoms, halogen, a hydroxyl group, a nitrogroup, group, carboxylic acid group, carboxylic acid derivative, or cyano; or R1= sec-butyl, tert-butyl-CH2; and R2=H, or R1= isobutyl and R2= methyl;

formula 6 represents a

where R4=H, alkyl or halogenated, alkoxy or alkylthio, halogenoalkane or allogeneically, each of which contains 1-4 carbon atoms, or a halogen, a hydroxyl group, a nitrogroup, group, carboxylic acid group, carboxylic acid derivative, or cyano; or R1= isobutyl, sec-butyl or tert-butyl-CH2; R2=H; or R1= isobutyl and R2= methyl.

Another variant implementation of the invention presents a way to counter the La pathogenic fungus, including the following steps: applying at least one composition of the compounds according to formulas 1-6 mixed with agronomically effective amount of the fungicide on the area near the pathogenic fungus. In one embodiment of the invention pathogenic fungus is a pathogen oomycetes mushroom, and the above mixture is applied to plant tissue before the pathogenic fungus initiates the infection.

Another variant implementation of the invention is a drug for the control of fungus, comprising at least one compound selected from the group comprising compounds of formulas 1-6, and at least one fungicide. In yet another embodiment of the invention fungicide effective against the fungus that produces motile zoospores. In yet another embodiment of the invention, one or more fungicides selected(s) from the group that includes MANCOZEB, MANEB, zineb, thiram, propineb, metiram, copper hydroxide, copper oxychloride, Bordeaux liquid, Captan, folpet, amisulbrom, AZOXYSTROBIN, Trifloxystrobin, picoxystrobin, kresoxim-methyl, fluoxastrobin, pyraclostrobin, famoxadone, fenamidone, metalaxyl, mefenoxam, benalaxyl, having cymoxanil, propamocarb, dimethomorph, floorf, mandipropamid, iprovalicarb, benthiavalicarb-isopropyl, valerenal, zoxamide, ethaboxam, ziazia the ID, fluopicolide, fluazinam, CHLOROTHALONIL, dithianon, fosetyl-Al, phosphorous acid, tolylfluanid and 4-forfinal-(1S)-1-({[(1R,S)-(4-cyanophenyl)ethyl]sulfonyl}methyl)propellernet. In yet another embodiment of the invention fungicide is a systemic fungicide based on copper compounds. In yet another embodiment of the invention, the fungicide may be a compound of the formula I

where R1 represents ethyl, 1-octyl, 1 nonyl or 3,5,5-trimethyl-1-hexyl, R2 represents methyl, ethyl, 1-propyl, 1-octyl, trifluoromethyl or methoxymethyl.

Another variant implementation of the method of controlling a fungal infection includes the following stages: receiving at least one drug, comprising at least one compound selected from compounds of formulas 1-6, and at least one fungicide, and application of agronomically effective amount of the preparation or mixture on the area near the mushroom. In yet another embodiment of the invention, the mixture comprising attractant derivative and fungicide, applied at least on one plant, leaves at least one plant, the stem of the at least one plant, the fruits of at least one plant, the territory adjacent to at least one plant, soil, seeds, seedlings, roots, liquid and solid growth medium the nutrient solution for hydroponics at least one plant.

In one embodiment of the invention, the preparation comprising at least one derived attractant zoospores and at least one fungicide, effective against pathogenic oomycete mushrooms, adapted to control diseases caused by pathogenic oomycete fungi selected from the group includingPhytophthora infestans,Plasmopara viticola,Phytophthora capsici,Pseudoperonospora cubensis,Bremia lactucae,Phytophthora phaseoli,Phytophthora nicotianevar. parasitica,Sclerospora graminicola,Sclerophthora rayssiae,Phytophthora palmivora,Phytophthora citrophora,Sclerophthora macrospora,Sclerophthora graminicola,Phytophthora cactorum, Phytophthorasyringe,Pseudoperonospora humuliandAlbugo candida.

In another embodiment of the invention derived attractant zoospores can release attractants zoospores, such as C4-C8 aldehydes or ketones selected from the group comprising isovaleraldehyde, 2-methylbutyraldehyde, valeraldehyde, Isobutyraldehyde, Butyraldehyde, 4-methylpentyl, 3,3-dimethylbutyramide, 3-methylthiopyridine, 2-cyclopropylethyl, 3-methylcrotonylglycine, 2-tilkroliarord, CROTONALDEHYDE, 2-methylcrotonate, 3-indolylmaleimide, furfural (2-furaldehyde), 2-thiophenecarboxaldehyde, 2-ethylbutyraldehyde, cyclopropanecarboxaldehyde, 2,3-dimethylformaldehyde, 2-methylvaleraldehyde, tetrahydrofuran-3-carboxaldehyde, cyclopent carboxaldehyde, 3-methyl-2-pentanone, 4,4-dimethyl-2-pentanone, 3,3-dimethyl-2-butanone and 4-methyl-2-pentanone.

It is understood that the substances that cause encystation of zoospores, such as pectin, metal ions, and inorganic compound or inorganic salt compound selected from the group comprising Ca, Zn, Mg, Mn, NaNO3, KNO3and NaCl, may be added to compositions containing fungicide and derived attractant zoospores to further improve disease control.

BRIEF DESCRIPTION of DRAWINGS

The figure 1 presents some acylhydrazone and semicarbazone derivatives of aldehydes and ketones used in accordance with the methods described in this invention and tested for their ability to attract zoospores.

The figure 2 presents summary data obtained by testing the ability of various acylhydrazones and semicarbazone derivatives of aldehydes and ketones to attract motile zoosporesPhytophthora capsici(PHYTCA) andPlasmoparaviticola(PLASVI).

DESCRIPTION

To facilitate understanding of the principles of the new technologies will continue to be made by reference to a variety of typical examples of their implementation, and their descriptions will be used specific terminology. However, you should imagine that the following examples are not intended to limit the possible scope of the new technology, so the specialist technical field to which the new technology will be clear to the proposed changes, modifications and further applications of the principles of the new technologies that are usually.

The present invention relates to compounds, which are or are capable of forming derivative compounds, which are attractants zoospores, these derivatives release attractants zoospores and can be used to improve the efficiency of fungicides to control plant diseases caused by pathogenic oomycetes. The methods according to the invention include contacting plants at risk of getting sick from pathogens oomycete that produces zoospores, with a composition containing an effective amount of a fungicide and derived attractant zoospores. Alternatively, a mixture of different attractants zoospores and derived attractants zoospores can be applied with a fungicide or a mixture of different fungicides.

Without going into theoretical basis, it is considered that the insert part of the fungicide derived attractant zoospores, coated or surrounded by particles of fungicide derived attractant zoospores to obtain a concentration gradient of attractant zoospores around the particle fungicide, which attracts zoospores to the fungicide may increase the power of the composition. By attraction of zoospores to the particles fungicide is possible to increase the area of disease control, to reduce the dose of fungicide or increase the duration of disease control. In addition, can be used over a wide range of fungicides, including fungicides, which have a limited redistribution on the surface of plants.

Without theory it is believed that using the derived attractant zoospores can improve the efficiency of fungicides active against zoospores, such as THIOCARBAMATE, for example, MANCOZEB, MANEB, zineb, thiram, propineb or metiram; fungicides based on copper compounds such as copper hydroxide, copper oxychloride or Bordeaux liquid; phthalimide fungicides, such as Captan or folpet; amisulbrom; strobilurin, for example, AZOXYSTROBIN, Trifloxystrobin, picoxystrobin, kresoxim-methyl, fluoxastrobin, pyraclostrobin and others; famoxadone; fenamidone; metalaxyl; mefenoxam; benalaxyl; having cymoxanil; propamocarb; dimethomorph; plumart; mandipropamid; iprovalicarb; benthiavalicarb-isopropyl; valerenal, zoxamide; ethaboxam; cyazofamid; fluopicolide; platinum; CHLOROTHALONIL; dithianon; fosetyl-Al, phosphorous acid; tolylfluanid or aminosulfonyl, such as 4-forfinal-(1S)-1-({[(1R,S)-(4-cyanophenyl)ethyl]sulfonyl}methyl)propellernet, or below triazolopyrimidine connection for example, the compounds of formula I:

where R1 represents ethyl, 1-octyl, 1 nonyl or 3,5,5-trimethyl-1-hexyl; and R2 represents a methyl, ethyl, 1-propyl, 1-octyl, trifluoromethyl or methoxymethyl.

Applicable derived attractants zoospores and attractants that they release can vary depending on the type of plant pathogenic fungus and environmental conditions. Typical attractants zoospores may include, for example, derivatives of C4-C8 aldehydes or C4-C8 ketones. Derived attractants zoospores can also be absorbed or incorporated into an inert substrate, such as PergoPak M, cornstarch, clay, latex agglomerates or particles of fertilizer.

Derived attractants zoospores can be used for such purposes as controlled release attractant molecules. Derived attractants zoospores are chemical compounds are usually obtained or produced from the molecules of the attractant zoospores. Derived attractants zoospores can be used in combination with attractants zoospores and fungicides. The appropriate derived attractants zoospores, such as acylhydrazone or semicarbazone various derivatives of aldehydes and ketones, can be less volatile and/or soluble in water than the corresponding aldehyde or ketone. Etoposide can produce or release attractants zoospores in contact derived from water on the surface of plants or area adjacent to the plant. Examples of technology gerasinomova derivative included in the PCT Patent Application No. WO2006016248 and an article entitled "Controlled release of volatile aldehydes and ketones by reversible hydrazone formation - 'classical' profragrances are getting dynamic" (Levrand et al., Chemical Communications (Cambridge, United Kingdom) 2006, pages 2965-2967 (ISSN: 1359-7345)). The content of each of the above publications are thus included in this description by reference. Various methods of synthesis of new and/or applicable acylhydrazones and semicarbazone derivatives presented in this description.

Reaction 1 below describes how the total derived attractant zoospores, which are presented above in formulas 1 through 6, releases the attractant zoospores upon contact with water. The receive rate of the attractant zoospores depends on many factors, including the physicochemical properties derived attractant zoospores, the composition of the drug-containing derivative, the presence and duration of presence of water on the surface of plants, as well as temperature, humidity and other environmental factors in the area of application. As you can see, the hydrolysis reaction is theoretically reversible, but this reversibility in real agricultural conditions will likely be low.

Reaction 1

The above derived attractants, top the R when used in combination with fungicides can provide particularly effective disease control, caused by pathogensPhytophthora infestans,Plasmopara viticola,Phytophthora capsiciandPseudoperonospora cubensis. Other pathogens that may also be controlled on various plants, such as tomatoes, potatoes, peppers, grapes, melons, lettuce, beans, sorghum, corn, citrus, grass, pecans, apples, pears, hops and plants of the cabbage family includeBremialactucae,Phytophthora phaseoli,Phytophthora nicotianevar. parasitica,Sclerospora graminicola,Sclerophthora rayssiae,Phytophthora palmivora,Phytophthora citrophora,Sclerophthora macrospora,Sclerophthora graminicola,Phytophthora cactorum,Phytophthora syringe,Pseudoperonospora humuliandAlbugo candida.

An effective amount derived attractant zoospores, which should be used often depends on the type of plant, growth stage of the plants, the severity of environmental factors, pathogenic fungus and conditions of use. Typically, a plant that needs protection from fungi, control fungi or their destruction, is subjected to contacting with the number derived attractant zoospores in the range of from about 1 to about 5000 ppm, preferably from about 10 to about 1000 ppm derived attractant zoospores. The contacting can be carried out in any effective way. For example, any open part of the plant, such as leaves or stems, you can spray proizvodnym of attractant zoospores in a mixture with effective doses of the fungicide. Derived attractant can be added to the drug itself with agronomically acceptable carrier and can be from 1 to 95% by weight of the preparation. One or more derived attractants can be co-injected into the drug with one or more attractants zoospores and one or more fungicides in the form of liquid or solid substances, where the attractant, derived attractant or a mixture of one or more attractants or derived attractant is from 1 to 50% of the drug.

The above-mentioned fungicides added derived attractant zoospores can be applied to the foliage of plants or to the soil or territory adjacent to the plant. In addition, fungicides added derived attractant zoospores can be mixed or used with any combination of herbicides, insecticides, bactericides, nematicides, miticides, biocides, termiticides, rodenticides, molluscicides, arthropodicides, fertilizers, growth regulators and pheromones.

Experimental part

The General scheme of the synthesis of various acylhydrazones and semicarbazones some derivatives of aldehydes and ketones according to the present invention is presented below in figure 1.

Scheme 1

Scheme 1 R1represents alkyl, R2represents hydrogen and methyl, R3represents an aliphatic group, n is 0-8.

The synthesis of compounds 10 and 12

Briefly, a mixture of 10.0 g (51,5 mmol) bisherige isophthalic acid, 150 ml of absolute ethanol and 124 mmol of aldehyde refluxed for 8-24 hours. Analysis by TLC indicates complete consumption of the original hydrazide. The mixture allow to cool to room temperature for several hours and then filtered. The resulting product in the form of a white solid is washed with ethanol and dried to constant weight in a vacuum oven at 40-50°C. the Product obtained in the form of a white solid, analyzed by NMR spectroscopy and elemental analysis, the results of the analyses confirm that the product meets the specified structure. Also determine the melting temperature.

Synthesis of compound 5

Briefly, in a dry round bottom flask of 250 ml, equipped with a magnetic stirrer, thermometer and reflux condenser, charged 10.0 g (57,4 mmol) dihydrazide adipic acid, 0.5 ml of glacial acetic acid and 150 ml of absolute ethanol. After dissolution, the greater part of the solids in the flask was added to 13.5 ml (126 mmol) of isovaleraldehyde and then the contents refluxed for 4 hours. The progress of the reaction is controlled via gra the ICA aliquots of the reaction mixture and HPLC. After the reaction proceeds almost to the end, the mixture is cooled to room temperature. The obtained solid is collected by vacuum filtration, washed with hexane and dried in vacuum at 40°C. Receive approximately 0.16 g of product as white solid (90% yield). Product structure corresponds to the structure of compound 5, as determined by analysis of 300 MHz1H-NMR and HPLC/MS. Melting point equal 204-206°C. Similar to the methods used to obtain compounds 1 through 9 and the compound (11), presented in figure 1.

Plan analysis activity attractant zoospores

Connection represented on figure 1, are tested for their ability to attract motile zoospores of two different fungi:Phytophthora capsici(PHYTCA) andPlasmopara viticola(PLASVI). Connection with sufficient solubility in water testing in the form of 5 mm solutions. Compounds with poor solubility crushed and tested in the form of a 10% suspension concentrates. Solutions, suspension concentrates are placed in a 1.0 cm capillary tube Drummond Size 2 microcap. The tube is placed in the hole 12-hole tablet and fix in place with a small drop of vacuum grease Dow Corning.

Briefly, for use in these analysesPhytophthora capsicigrown on V-8 agar. When the culture reaches the age of 5-7 days and abundantly produces sporangia, producerof is their zoospores initiated by adding 15 ml of sterile water onto the tablet. After 10 minutes at room temperature submerged tablet is placed in a refrigerator at 4°C and kept in the refrigerator for 20 minutes. The tablet then again incubated at room temperature for 30-60 minutes. After a suspension of zoospores filtered through filter paper Whatman 113V.

To initiate the production of zoosporesPlasmopara viticolasporangia collected from three grape leaves (Vitis Vinifera cv Carignane)is completely positive for the abundant sporulation. Infected leaves are placed in deionized water and the sporangia are removed from the leaves easy cleaning leaves. The solution containing sporangia were removed, incubated at room temperature for 10 minutes. After this, the solution is transferred into a refrigerator and kept in the refrigerator at 4°C for 20 minutes and then at room temperature for 60 to 90 minutes, which is formed in the solution a large number of zoospores. A suspension of zoospores then filtered through filter paper Whatman 113 V.

About 1 ml of a suspension of zoospores placed in wells containing capillaries with chemicals, attractant activity which is subject to investigation. After 60 to 90 minutes level interchannel activity determined by visual inspection of the capillary tube and the solution under microscopy is ω and comparing the number of zoospores, which floats in the capillary tube, with the number of zoospores in the external solution. This ratio semiquantitative estimate on a scale from 1 to 10, where 1 corresponds to no accumulation of zoospores inside the capillary, 2 represents the accumulation of zoospores inside the capillary, approximately equal to the density of zoospores in the external solution, 5 represents an accumulation, about 5 times greater than the density of the external solution, and 10 represents complete filling of the capillary zoospores with a density that is too large to quantify. The average score in the range of 1-3 defines weak attractant activity; the average score in the range of 4-7 classified as moderate attractant activity; the average score in the range of 8-10 classified as high attractant activity. The obtained results are shown in figure 2. Alternatively, this method techniques attractants ability against zoospores that are specified in the section "prior art", are also generally applicable and can be successfully applied.

Compounds according to the present invention, having the properties of attractant zoospores may preferably be combined with a number of fungicides, in particular fungicides, which are active against pathogenic oomycete mushrooms. Apply fungicides include fungicides, selected the s of MANCOZEB, of MANEB, zineb, Tirana, propineb, metiram, copper hydroxide, copper oxychloride, Bordeaux liquid, Captan, folpet, amisulbrom, AZOXYSTROBIN, Trifloxystrobin, picoxystrobin, kresoxim-methyl, fluoxastrobin, pyraclostrobin, famoxadone, fenamidone, metalaxyl, mefenoxam, benalaxyl, cymoxanil, propamocarb, dimethomorph, plumeria, mandipropamid, iprovalicarb, benthiavalicarb-isopropyl valerenal, zoxamide, ethaboxam, cyazofamid, fluopicolide, fluazinam, CHLOROTHALONIL, dithianon, fosetyl-Al, phosphorous acid, tolylfluanid, 4-forfinal-(1S)-1-({[(1R,S)-(4-cyanophenyl)ethyl]sulfonyl}methyl)propylgallate and triazolopyrimidine compounds, such as compounds represented by the formula I:

where R1 represents ethyl, 1-octyl, 1 nonyl or 3,5,5-trimethyl-1-hexyl, R2 represents methyl, ethyl, 1-propyl, 1-octyl, trifluoromethyl or methoxymethyl.

Compounds according to the present invention is preferably applied in the form of a composition containing one or more compounds of formulas 1-6 and acceptable for vegetation media. The compositions are either concentrated preparations, which are dispersed in water or other liquid for use, or dusty or granular products, which are used without further about the processing. The compositions have, in accordance with techniques which are conventional in the field of chemistry, but which are new and important due to the presence of compounds according to the present invention. Some descriptions of obtaining the compositions presented below to ensure that experts in the field of Agrochemistry can easily get the desired composition.

Dispersion, in which the applied compounds are often aqueous suspension or emulsion, obtained from concentrated preparations of compounds. Such water-soluble, suspendiruemye in water or emulsifiable in water preparations are solid, usually known as wettable powders, or liquids, usually known as emulsion concentrates or aqueous suspension. The present invention involves all media, with which the compounds according to the present invention can be formulated for delivery with a fungicide. It is easy to understand that can be used any material to which these compounds may be added, if it results in the desired application without significant effect on the activity of the compounds according to the present invention.

Wettable powders, which can pressoffice with the formation of water-dispersible granules are uniform cosbyology active substances, inert carrier, and surfactants. The concentration of the active ingredient usually makes up from about 1% to about 95% wt./mass., more preferably from about 1% to about 50% wt./mass. Upon receipt of the compositions in the form of wettable powders, the active compound may be combined with any fine solids, such as profilic, talc, chalk, gypsum, mullerova earth, bentonite, attapulgite, starch, casein, gluten, montmorillonite clay, diatomaceous earth, purified silicates, etc. In such operations, the finely ground carrier is ground or mixed with the active compound in a volatile organic co-solvent. Effective surfactants, comprising from about 0.5% to about 10% wettable powder, include from sulphonated lignins, naphthalenesulfonate, alkylbenzenesulfonate, alkyl sulphates and nonionic surfactants, such as the reaction products of the accession of ethylene oxide and alkyl phenols.

Emulsion (emulsifiable) concentrates of the compounds according to the present invention include the compounds in suitable concentrations, for example, from about 10% to about 50% wt./mass., in a suitable liquid. Compounds are dissolved in an inert carrier, which is either cm is simoudis with water, the solvent, or mixture is not miscible with water and organic solvents and emulsifiers. The concentrates can be diluted with water and butter to create mixtures for spraying in the form of emulsions of the type oil-in-water". Applicable organic solvents include aromatic hydrocarbons, in particular, high-boiling naphthalene and olefinic petroleum fractions such as heavy aromatic naphtha. Can use other organic solvents, such as, for example, terpene solvents, including derivatives of rosin, aliphatic ketones, such as cyclohexanone, and complex alcohols such as 1-ethoxyethanol.

Emulsifiers that can be successfully used in this invention can be easily determined by the expert of the art, and include various nonionic, anionic, cationogenic, amphoteric emulsifiers or a mixture of two or more emulsifiers. Examples of nonionic emulsifiers which can be used in the production of emulsion concentrates, include simple polyalkylene glycol ethers and condensation products of alkyl - and kilfenora, aliphatic alcohols, aliphatic amines or fatty acids with ethylene oxide, propyleneoxide, such as ethoxylated alkyl phenols, and esters of carboxylic acids, solubilization polyhydric alcohol or polyoxyalkylene Cationogenic emulsifiers include Quaternary ammonium compounds and salts of fatty amines. Anionic emulsifiers include soluble in oil salt (e.g. calcium) alkylarylsulfonates, soluble in oils simple salt of the sulfated polyglycolic esters, and suitable salts of simple phosphated polyglycolic ether.

Typical examples of organic liquids that can be used for emulsion concentrates according to the present invention are aromatic liquids such as xylene, propylbenzene fraction or mixed naphthalene fractions, mineral oils, liquid substituted aromatic compounds, such as dioctylphthalate, kerosene and dialkylamide various fatty acids; in particular dimethylamide different fatty glycols and glycol derivatives, such as a simple n-butyl ether, simple ethyl ester or a simple methyl ether of triethylene glycol. For emulsion concentrates are often used a mixture of two or more organic liquids. Preferred organic liquids are xylene and propylbenzene faction, and xylene is preferred. In liquid compositions, as a rule, applied surface-active dispersing agents in an amount of from 0.1 to 20 percent by weight based on the total weight of dispersing agent and an active connection. Active is oppozitsii can also contain other compatible additives, for example, plant growth regulators and other biologically active compounds used in agriculture. It is understood that the substances that cause encystation of zoospores, such as pectin, metal ions, and inorganic compound or salt of inorganic compounds selected from the group comprising Ca, Zn, Mg, Mn, NaNO3, KNO3and NaCl, may be added to the composition containing the fungicide and derived attractant zoospores, to further improve disease control.

Aqueous suspensions include suspension of water insoluble compounds according to the invention dispersed in an aqueous medium in a concentration in the range from 5% to 50 wt%./mass. Suspension get thin grinding compound and thoroughly mixing it with a carrier comprising water and a surface-active substances selected from the above surfactants. Inert ingredients, such as inorganic salts and synthetic or natural resins, can also be added to increase the density and viscosity of aqueous media. Often the most effective is the simultaneous grinding and mixing of compounds through the cooking water mixture and homogenizing it in a suitable equipment, such as a sand mill, a ball mill or a homogenizer of porn the new type.

Connections can also be used in the form of granular compositions that are especially useful for soil. Granular compositions typically contain from about 0.5% to about 10% wt./mass. compounds dispersed in an inert carrier which is completely or mostly consists of roughly crushed attapulgite, bentonite, diatomaceous earth, clay or similar inexpensive substances. Such compositions are generally obtained by dissolving the compound in a suitable solvent and applying the solution on granular media, which is then ground to particles of a suitable size in the range from 0.5 to 3 mm, Such compositions can also be obtained through the dough or paste, which consist of media and connections, and grinding and drying to obtain granulated particles of the desired size.

Dusty containing compounds, produced simply by thorough mixing of compounds in powder form with a suitable agricultural carrier in the form of dust, such as, for example, kaolin, crushed volcanic rock, etc. Dusty can suitably contain from about 1% to about 10% wt./mass. connection.

The active composition may contain a surface-active adjuvants to enhance deposition, wetting and penetration of composers who s in the target culture and the body. Such surface-active adjuvants may optionally be used as a component of the drug or as a mixture, obtained in a separate container. The amount of surface-active adjuvant will vary in the range from 0.01 percent to 1.0 percent.about. based on the volume of water for spraying, preferably in the range from 0.05 to 0.5 percent. Suitable surface-active adjuvants include ethoxylated nonylphenols, ethoxylated synthetic or natural alcohols, salts of esters sulfonterol acid, ethoxylated organic sulfolane, ethoxylated fatty amines and mixtures of surface-active substances with mineral or vegetable oils.

The composition may optionally contain fungicidal combinations that include at least 1% of one or more compounds according to the present invention with another pesticide compound. Such additional pesticidal compounds may include fungicides, insecticides, nematicides, miticide, arthropodicides, bactericides or combinations thereof that are compatible with the compounds according to the present invention in the medium selected for application, but are not antagonists in relation to the activity of the compounds according to the present invention. Accordingly, in such embodiments, domestic the invention other pesticide compounds are used as an additional toxicant for the same or other pesticide applications. Usually compounds in combination may be present in a ratio of from 1:10 to 100:1.

The present invention includes within its scope methods of control or prevent exposure to fungi. These methods include the application in the center of the spread of fungi or in a place that should be protected from contamination (for example, coating the potatoes, tomatoes, pumpkin or plants of grapes), an effective amount of one or more compounds according to the present invention and an agronomically effective amount of the fungicide active against oomycete mushrooms. Compounds according to the present invention are suitable for processing various plants, if you are low phytotoxicity with respect to those plants. Compounds according to the present invention are used in any of many known methods as compounds or compositions comprising these compounds. For example, the compounds can be applied to the foliage, flowers, stems, fruits, plants, the area adjacent to the plant, soil, seeds, seedlings, roots, liquid and solid culture media and nutrient solutions for hydroponics for control of various fungi without prejudice to the commercial value of the plants. Materials are used in the form of the preparation of any of the commonly used types of drugs, for example, in the form of solutions, gusto is, wettable powders, flowable concentrates or emulsion concentrates. These materials are conveniently used various known methods.

Compounds according to the present invention have a wide range of effective antifungal drugs. The exact amount derived attractant zoospores, which are to be applied, depends not only on the specific derived attractant zoospores, which will be applied, but also on the specific desired actions, species of fungi to be controlled, the stage of their growth, as well as parts of the plant or other object that may come in contact fungicide effective ingredient. Thus, the compounds according to the present invention and compositions containing these compounds, may not have equal effectiveness in similar concentrations or against the same type of fungus. Compounds according to the present invention and their compositions in mixtures with fungicides effective against plants in terms of inhibition of disease in filologicheskie acceptable quantities.

Although new technology has been illustrated and described in detail using the drawings the above description, the drawings and description should be considered illustrative, and not having restrictive, it should be present, what could the t to be shown and described only various typical examples of embodiments of the invention and that all changes and modifications which relate to the field of new technology must be protected. In addition, while new technology was illustrated by concrete examples, and theoretical evidence, calculations and illustrations these illustrations and the accompanying discussion in no way should be construed as limiting this technology. All patents, patent applications, and links to texts, scientific treatises, publications, etc. mentioned in this application are included in this description in its entirety by reference.

1. A compound selected from the group including formula 1, formula 2, formula 3, formula 4, formula 5 and formula 6, where the formula 1 represents a

where R1= isobutyl, sec-butyl or tert-butyl-CH2;
R2=H;
n=0-25;
formula 2 represents a

where R1= sec-butyl or tert-butyl-CH2;
R2=H;
formula 3 represents a

where R1= isobutyl, sec-butyl or tert-butyl-CH2;
R2=H;
formula 4 is a

where R1= isobutyl;
R2=H;
R3= n-alkyl containing 2-25 carbon atoms, with the exception of n-heptyl and n-undecyl, branched alkyl containing 4-25 carbon atoms, substituted or unsubstituted what th cycloalkyl, contains 3-25 carbon atoms, or a substituted or unsubstituted arylalkyl containing 12-26 carbon atoms;
or
R1= sec-butyl or tert-butyl-CH2;
R2=H;
R3= n-alkyl containing 1-25 carbon atoms, branched alkyl containing 3-25 carbon atoms, substituted or unsubstituted cycloalkyl containing 7-25 carbon atoms, or a substituted or unsubstituted arylalkyl containing 7-25 carbon atoms;
or
R1= isobutyl;
R2= methyl; and
R3= n-alkyl containing 2, 3, 6 and 12-25 carbon atoms, branched alkyl containing 3-25 carbon atoms, substituted or unsubstituted cycloalkyl that contains 3-25 carbon atoms, or a substituted or unsubstituted arylalkyl containing 7-25 carbon atoms;
formula 5 is a

where R4=H, alkyl, halogenated, alkoxy, alkylthio, halogenoalkane or allogeneically, each of which contains 1-4 carbon atoms, or a halogen, a hydroxyl group, a nitro-group, a carboxylic acid group, or cyano;
and either
R1= sec-butyl or tert-butyl-CH2;
R2=H;
or
R1= isobutyl; and
R2= methyl; and
formula 6 is a

where R4= H, alkyl, halogenated, alkoxy, alkylthio, halogenoalkane, allogeneically, each the first of which contains 1-4 carbon atoms, or halogen, a hydroxyl group, a nitro-group is a carboxylic acid group, or cyano; and
or
R1= isobutyl, sec-butyl or tert-butyl-CH2;
R2=H;
or
R1= isobutyl; and
R2= methyl.

2. The compound according to claim 1, where R1 is isobutyl and R2 represents a hydrogen in formulas 1, 3, 4, and 6.

3. The way to attract zoospores of plant pathogenic oomycete fungi, comprising applying a compound according to claim 1.

4. The method according to claim 3, where the zoospores are disputes of at least one plant pathogenic oomycete fungus selected from the group including Phytophthora infestans, Plasmopara viticola, Phytophthora capsici, Pseudoperonospora cubensis, Bremia lactucae, Phytophthora phaseoli, Phytophthora nicotiane var. parasitica, Sclerospora graminicola, Sclerophthora rayssiae, Phytophthora palmivora, Phytophthora citrophora, Sclerophthora macrospora, Sclerophthora graminicola, Phytophthora cactorum, Phytophthora syringe, Pseudoperonospora humuli and Albugo Candida.

5. The method according to claim 3, in which zoospores are disputes of at least one plant pathogenic oomycete fungus selected from the group including Phytophthora infestans, Plasmopara viticola, Phytophthora capsici and Pseudoperonospora cubensis.

6. The method of controlling plant pathogenic oomycete fungus, comprising the following stages:
software composition containing at least one compound according to claim 1 and at least one fungicide, where the fungicide is effective against Pato is built oomycete mushrooms, and,
application of agronomically effective amount of the composition to the plant.

7. The composition for controlling plant pathogenic oomycete fungus, including
at least one compound according to claim 1 and
at least one fungicide.

8. The composition according to claim 7, where the fungicide is effective against plant pathogenic oomycete fungus that produces motile zoospores.

9. The composition of claim 8, where the fungicide is selected from the group consisting of MANCOZEB, MANEB, zineb, thiram, propineb, metiram, copper hydroxide, copper oxychloride, Bordeaux liquid, Captan, folpet, amisulbrom, AZOXYSTROBIN, Trifloxystrobin, picoxystrobin, kresoxim-methyl, fluoxastrobin, pyraclostrobin, famoxadone, fenamidone, metalaxyl, mefenoxam, benalaxyl, having cymoxanil, propamocarb, dimethomorph, floorf, mandipropamid, iprovalicarb, benthiavalicarb-isopropyl, valerenal, zoxamide, ethaboxam, cyazofamid, fluopicolide, fluazinam, CHLOROTHALONIL, dithianon, tolylfluanid, 4-forfinal-(1S)-1-({[(1R,S)-(4-cyanophenyl)ethyl]sulfonyl}methyl)propellernet and triazolopyrimidine the compounds of formula I:

where R1 represents ethyl, 1-octyl, 1 nonyl or 3,5,5-trimethyl-1-hexyl, R2 represents methyl, ethyl, 1-propyl, 1-octyl, trifluoromethyl or methoxymethyl.

10. The composition according to claim 7, where the composition additionally who cancel at least one derived attractant zoospores.

11. The composition according to claim 7, where the fungicide is not a fungicide based on copper compounds.

12. The composition according to claim 7, where the fungicide is selected for control of diseases caused by plant pathogenic oomycete fungi selected from the group including Phytophthora infestans, Plasmopara viticola, Phytophthora capsici, Pseudoperonospora cubensis, Bremia lactucae, Phytophthora phaseoli, Phytophthora nicotiane var. parasitica, Sclerospora graminicola, Sclerophthora rayssiae, Phytophthora palmivora, Phytophthora citrophora, Sclerophthora macrospora, Sclerophthora graminicola, Phytophthora cactorum, Phytophthora syringe, Pseudoperonospora humuli and Albugo Candida.

13. The composition of claim 10, where the derived attractant oomycete zoospores releases C4-C8 aldehyde selected from the group comprising isovaleraldehyde, 2-methylbutyraldehyde, valeraldehyde, Isobutyraldehyde, Butyraldehyde, 4-methylpentyl, 3,3-dimethylbutyramide, 3-methylthiopyridine, 2-cyclopropylethyl, 3-methylcrotonylglycine, 2-tilkroliarord, CROTONALDEHYDE, 2-methylcrotonate, 3-indolylmaleimide, furfural (2-furaldehyde), 2-thiophenecarboxaldehyde, 2-ethylbutyraldehyde, cyclopropanecarboxaldehyde, 2,3-dimethylformaldehyde, 2 - methylvaleraldehyde, tetrahydrofuran-3-carboxaldehyde and cyclopentanecarboxaldehyde.

14. The composition of claim 10, where the derived attractant oomycete zoospores releases C4-C8 ketone.

15. The method of controlling a fungal infection, comprising the following stages:
providing at least one from the tava according to claim 9;
application of agronomically effective amount of the specified drug sensitive plants or to the area near the plant pathogenic oomycete fungus.

16. The method of controlling plant diseases caused by plant pathogenic oomycete mushrooms, which includes the following stages:
receiving the drug, comprising the composition according to claim 7,
application of agronomically effective amount of the drug on at least one of the following: plant, leaf, flower, stem, fruit plants, the area near the plants, the soil near the plants, seeds, seedlings, roots, liquid and solid growth media and solutions for hydroponics.

17. The method according to clause 16, where the plant is a grape, potato, tomato, cucumber, pumpkin or other squash plant, cabbage, or other plant of the cabbage family, lettuce, beans, corn, soybean, pepper, or hops.



 

Same patents:

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a compound presented by formula

,

wherein A1 means benzene or heterocycle specified in a group consisting of pyridine, pyrazine, imidazole, thiazole, pyrimidine, thiophen, pyridazine, benzoxazine and oxobenzoxazine; A2 means benzene, if needed substituted by fluorine, or thiophen; B1 means hydrogen, lower alkyl, if needed substituted by piperazinyl or morpholino, halogen-substituted lower alkyl, lower alkoxy substituted by carbamoyl, acylamino, carbamoyl or lower alkylcarbonyloxy (provided A1 means thiazole, B1 does not mean acylamino); B2 means hydrogen or a functional group containing at least one nitrogen atom specified in a group consisting of acylamino, pyrrolidinyl, morpholino, piperidinyl, if needed substituted by acyl, piperazinyl, if needed substituted by lower alkyl or acyl, pyrazolyl, diazabicyclo[2.2.1]heptyl, if needed substituted by acyl, and di-(lower alkyl)amino, if needed substituted by amino or acylamino (provided A1 means thiazole, B2 does not mean acylamino); Y means a group presented by formula

,

wherein J means ethylene or lower alkynylene; L means a bond; M means a bond; X means -(CH2)m-, -(CH2)m-O- or -(CH2)m-NR2- (wherein m is an integer of 0 to 3, and R2 means hydrogen); D means -NR3-, wherein R3 means hydrogen; and E means amino, or its pharmaceutically acceptable salt. The compounds of formula (I) are used for preparing a pharmaceutical agent or a pharmaceutical composition for treating or preventing the VAP-1 related diseases.

EFFECT: benzene or thiophen derivative as a VAP-1 inhibitor.

13 cl, 25 tbl, 125 ex

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of general formula III and their pharmaceutically acceptable salts, A represents (C1-C6)alkyl-O-, phenyl-(C1-C6)alkyl-O-; aryl, selected from phenyl, naphthyl, and which is possibly substituted by 1-3 substituents, given in the invention formula; or heteroaryl, which has four or five carbon atoms and one heteroatom, selected from oxygen, nitrogen and sulphur, which is possibly substituted by 1-3 substituents, given in the invention formula; B represents phenyl, possibly substituted by 1-3 substituents, where substituents are selected from (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkyl-O-, hydroxy, amino and halogeno; and R1 and R2 independently represent (C1-C6)alkyl, phenyl-(C1-C6)alkyl-, hydroxy-(C1-C6)alkyl, (C3-C7)cycloalkyl, (C2-C6)alkenyl or (C2-C6)alkynyl; on condition that R1 is different from R2; where absolute configuration of asymmetric R1 and R2 -carrying carbon atom is mainly R-configuration. Invention also relates to pharmaceutical composition, possessing ability to modulate gene expression, methods of modulation of gene expression in host cell, method of regulating expression of endogenous or heterologous gene in transgenic subject, method of regulating transgenic expression in transgenic subject, method of polypeptide production and to method of obtaining formula IV compound. Method includes stages: a) interaction of formula V compound with formula IV compound with obtaining formula VII compound; b) reduction of formula VII compound with obtaining formula VIII compound, b) interaction of formula VIII compound with formula B-CO-LG compound, where B has values, given above, and LG is leaving group representing -F, -Cl or -Br, with formation of formula IX compound, d) removal of group R7CO2- from formula IX compound with obtaining formula X compound, e) interaction of formula X compound with formula A-CO-LG compound, where A has values, given above, and LG is leaving group, representing -F, -Cl or -Br, with obtaining formula IV compound ( compounds of formulas V, VI, VII, VIII, IX, X are given in the invention formula).

EFFECT: obtaining formula III compounds, possessing ability to modulate gene expression.

19 cl, 4 ex, 2 tbl, 78 ex

FIELD: chemistry.

SUBSTANCE: invention claims a new method of obtaining 3,5-diamino-6-(2,3-dichlorphenyl)-1,2,4-triazine of high purity degree by reaction of 2,3-dichlorbenzoylcyanide with 1-2 mol equivalents of dimethylase aminoguanidine salt in the presence of 3-6 mol equivalents of methanesulfoacid, with further addition of 2-5 mol equivalents of magnesium oxide to the reaction mix. The process is performed at 50-80°C, and target product is recrystallised from acetone.

EFFECT: improved efficiency of compounds.

5 cl, 3 ex

The invention relates to compounds of the formula

where R represents hydrogen or CO2CH(CH3)2

The invention relates to a method for producing crystals aminoguanidine-bicarbonate interaction of an aqueous solution of cyanamide and an aqueous solution of hydrazine hydrate is added in the presence of CO2where the process is carried out with a small deficit of cyanamide in relation to its stoichiometric amount in molar ratio cyanamide/hydrazine from 0.8 to 0.99

Aminoguanidinium // 2162462

The invention relates to new methods of producing pharmaceutically active bicyclic amidinothiourea of amidinohydrolase, and to new bicyclic to hydroxyamides, which are intermediate compounds for obtaining pharmaceutically active bicyclic amidinothiourea of amidinohydrolase, in the form of various tautomeric forms, as well as a mixture of tautomers; and/or, if they euda soleobrazutaya group, in the form of salts

The invention relates to compounds having the structural formula I, where X, Y, R and Z are defined in the description of the application

The invention relates to derivatives of amino, aminopentanoic, aminohexanoic acids of General formula I

< / BR>
where R1- A-COOR10; - (CH2)m-CONHOR10, -CONHNHR10, -(CH2)nSR50or-Y-P (OR51)2; m = 0, 1, 2; n = 0-3; each R2, R3, R4, R5, R6and R7independently is hydrogen, C1-8 alkyl, C2-8 alkenyl, -OR11, -SR11, -NR12R13, Cycle 1, C1-8 alkyl, substituted OR11, -SR11, -NR12R13, -COR14, guanidino or Cycle 1, or C2-8 alkenyl, substituted OR11, -SR11, -NR12R13, -COR14, guanidino or Cycle 1, or R3and R4taken together, represent a C1-8 alkylene, R5and R6taken together, represent a C1-8 alkylene, R3and R6taken together, represent a C1-8 alkylene, R2and R3taken together, represent a C2-8 alkylene, R4and R5taken together, represent a C2-8 alkylene or R6and R7taken together, represent a C2-8 alkylene, or (1) R8represents 1) hydrogen, 2) C1-8 alkyl, 3) C1-8 alkoxycarbonyl, 4) C1-8 alkyl, substituted OR26, -SR26, -NR27R28ips.ru/fullimg4/rupat5/2003/11/01/2215735-2t.gif" ALIGN="ABSMIDDLE">< / BR>
(2) R8represents a

< / BR>
< / BR>
R9represents 1) a C1-8 alkyl, 2) C1-8 alkoxy, 3) C1-8 alkoxy, substituted Cycle 2, 4) C1-8 alkyl, substituted OR26, -SR26, -NR27R28, -COR29or Cycle 2, or

5)< / BR>
A - C3-15mono-, bi - or tricarboxylic or 5-18 membered mono - bi - or trigeneration ring containing 1 to 4 nitrogen atoms, 1 to 2 oxygen atoms and/or 1 to 2 sulfur atoms or its non-toxic salts, and the inhibitor of matrix metalloproteinases, containing as active ingredient a compound I

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. The fungicidal composition contains tolclofos-methyl, polyoxyethylene polyaryl phenol phosphate, a polyoxyethylene and polyoxypropylene block-copolymer, a polyoxyethylene ester of a fatty alcohol and water.

EFFECT: invention improves stability of the composition at high temperature.

6 cl, 2 tbl, 4 ex

FIELD: chemistry.

SUBSTANCE: invention relates to halogen-6-(aryl)-4-iminotetrahydropicolinic acids of formula I, where R represents -OS(O)2R1 or -OC(O)R1; R1 represents C1-C4-alkyl or phenyl, substituted with C1-C4-alkyl; R2 represents C1-C4-alkyl; Q represents Cl or Br; W represents H, F or Cl; X represents H or C1-C4-alkoxygroup; Y represents a halogen atom; and Z represents H or F. The invention also relates to herbicidal compositions based on the claimed formula (I) compound.

EFFECT: obtained are novel compounds and based on them herbicidal compositions, which can be applied in agriculture for the suppression of undesirable vegetation.

4 cl, 3 tbl, 19 ex

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. Fungicidal composition contains: A) copper salicylate, which has the following molecular formula C7H4O3Cu·(H2O) (I), where n represents 0, 1, 2 or 3; B) copper hydroxide Cu(OH)2 (II); C) copper salt, which has the following formula 3Cu(OH)2·X(Y)m (III), where: X represents copper ion Cu2+; Y stands for chloride-ion Cl-; m represents integer number, equal 2; possibly in presence of dispersants, diluents, surface-active substances and/or agronomically acceptable coformulants.

EFFECT: invention makes it possible to increase composition and preparation activity.

10 cl, 1 tbl, 12 ex

FIELD: agriculture.

SUBSTANCE: rodenticide composition comprises the active ingredient - poison of acute action, the gelling agent, the dye. As the poison of acute action it comprises zinc phosphide or glyfluor or monofluoride or fluoroacetamide, or barium fluoroacetate, additionally as gelling agent it comprises a mixture of xanthan and carob gum, taken in weight ratio equal to (1-9):(1-9), respectively, or a mixture of carrageenan and carob gum, taken in weight ratio equal to (1-9):(1-9), respectively, or a mixture of xanthan and guar gum, taken in weight ratio equal to (1-9):(1-9), respectively, also comprises water, or milk, or milk whey in the following ratio, wt %: poison of acute action 0.5-5.0; mixture of xanthan and carob gum, taken in weight ratio equal to (1-9): (1-9), respectively, or a mixture of carrageenan and carob gum, taken in weight ratio equal to (1-9):(1-9), respectively, or a mixture of xanthan and guar gum, taken in weight ratio equal to (1-9):(1-9), respectively, 0.3-15; dye 0.02-0.05; water, or milk, or milk whey - the rest.

EFFECT: invention enables to use the composition in subzero temperatures.

7 cl, 331 ex

FIELD: agriculture.

SUBSTANCE: invention relates to agriculture. For controlling the agricultural crop induced with pathogen of disease, the identification of one or several plants is carried out, with the risk of development of the disease from the pathogen resistant to Qo inhibitor, and contacting of the said one or several plants with a composition comprising an effective amount of Qi inhibitor.

EFFECT: invention enables to implement the specified assignment.

14 cl, 3 tbl, 2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. Fungicidal composition contains:

A) tetrazolyloxime derivative of formula ,

where A represents tetrazoyl group of formula ,

where Y represents alkyl group; and - Het represents pyridyl group of formula ,

where Z represents group of formula QC(=O)NH-, where Q. represents alkoxyl group, having from 1 to 8 carbon atoms; and B) fungicidal compound, selected from the list, consisting of bixafen, boscalid, azoxystrobin, fluoxastrobin, pyraclostrobin, trifloxystrobin, fluazinam, fludioxonil, iprodione, propamocarb, propamocarb hydrocloride, prothiocozanole, tebuconazole, iprovalicarb, chlorothalonil, mancozeb, propineb, N-[2-(1,3-dimethylbutyl)phenyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide, cymoxanil, fosetyl aliminium, fosetyl calcium, fosetyl sodium and propamocarb fosetylate, with weigh ratio A/B in the range from 1/0,01 to 1/100 Application of agronomically efficient and in fact non-phytotoxic quantity of said composition is carried out to treat seeds, apply on leaves, and apply on stems and trunks.

EFFECT: invention makes it possible to increase treatment efficiency.

20 cl, 6 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. The high-viscosity oil-based agrochemical composition includes (a) biocides, (b) hydrophobic carriers and (c) polymers selected from a group consisting of poly(meth)acrylates, polymaleates and polyfumarates.

EFFECT: invention increases viscosity of the composition.

14 cl, 3 tbl, 3 ex, 1 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. A composition for stabilising an agriculturally active compound contains an oil-in-water emulsion which includes an oil phase and an aqueous phase. The oil-in-water emulsion contains sodium chloride, at least one agriculturally active compound, at least one nonionic lipophilic surfactant having hydrophilic-lipophilic balance in the range of 2 to 5, at least one nonionic hydrophilic surfactant having hydrophilic-lipophilic balance in the range of 8 to 12, at least one ionic surfactant and at least polymeric surfactant. The composition is deposited on fungi, soil, plants, seeds and an insect, weed, bacteria, rodent and termite control area.

EFFECT: invention increases stability of agriculturally active compounds.

26 cl, 6 tbl, 3 ex

FIELD: chemistry.

SUBSTANCE: invention relates to biocides. The synergetic antimicrobial composition contains: (a) a hydroxymethyl-substituted phosphorus compound, which is a tetrakis(hydroxymethyl)phosphonium salt, and (b) a second biocide selected from a group comprising (1) hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine, (2) 2,6-dimethyl-1,3-dioxan-4-ylacetate and (3) ortho-phenylphenol or alkali metal salts or ammonium salts thereof. The weight ratio of the hydroxymethyl-substituted phosphorus compound to hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine ranges from 15:1 to 1:15. The weight ratio of the hydroxymethyl-substituted phosphorus to 2,6-dimethyl-1,3-dioxan-4-ylacetate ranges from 15:1 to 1:15. The weight ratio of hydroxymethyl-substituted phosphorus compound to ortho-phenylphenol or alkali metal salts or ammonium salts thereof ranges from 15:1 to 1:5.

EFFECT: invention increases effectiveness of the composition.

7 cl, 6 tbl, 6 ex

FIELD: chemistry.

SUBSTANCE: preparation can be applied for elimination of fungi and in treatment of diseases, caused by fungi, as well as for the prevention of damage by fungi to different materials and agricultural products. The fungicidal preparation represents an associate of 5-[3,5-dichloro-2-hydroxybenzylidine)amino]-4-hydroxy-1H-pyrimidine-2-one with 1,2,3,4,5-pentahydroxy-6-methylaminohexane and corresponds to the following formula: . Compounds were obtained in the crystalline form, and their structure is proved by spectra of proton magnetic resonance in dimethylsulphoxide.

EFFECT: preparation has a wide spectrum of action and high solubility, which increases efficiency of its application in the form of solutions.

2 tbl, 6 ex

FIELD: chemistry.

SUBSTANCE: invention relates to agriculture. Fungicidal composition contains:

A) tetrazolyloxime derivative of formula ,

where A represents tetrazoyl group of formula ,

where Y represents alkyl group; and - Het represents pyridyl group of formula ,

where Z represents group of formula QC(=O)NH-, where Q. represents alkoxyl group, having from 1 to 8 carbon atoms; and B) fungicidal compound, selected from the list, consisting of bixafen, boscalid, azoxystrobin, fluoxastrobin, pyraclostrobin, trifloxystrobin, fluazinam, fludioxonil, iprodione, propamocarb, propamocarb hydrocloride, prothiocozanole, tebuconazole, iprovalicarb, chlorothalonil, mancozeb, propineb, N-[2-(1,3-dimethylbutyl)phenyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide, cymoxanil, fosetyl aliminium, fosetyl calcium, fosetyl sodium and propamocarb fosetylate, with weigh ratio A/B in the range from 1/0,01 to 1/100 Application of agronomically efficient and in fact non-phytotoxic quantity of said composition is carried out to treat seeds, apply on leaves, and apply on stems and trunks.

EFFECT: invention makes it possible to increase treatment efficiency.

20 cl, 6 tbl

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