Method for prevention and treatment of computer fatigue syndrome (cfs) and cellular transmission fatigue syndrome (ctfs)

FIELD: medicine.

SUBSTANCE: method involves administration of low-mineralised chloride-hydrocarbonate sodium, alkaline, boron high-magnesium, -iodine, -fluorine natural mineral water 'Lazarevskaya Tselebnaya' No.11-M of the Soloniki deposit and No. 84-M of the Volkonskoye deposit in Sochi. Mineral water is administered 17-19 minutes before meals in a dose of 170-190 ml in gulps at 23-24°C. The water is administered daily, six times a day for at least 24-30 days. The course of water administration is repeated every three months for three years.

EFFECT: method provides higher clinical effectiveness ensured by improving the metabolic processes in the brain.

2 cl, 7 tbl

 

blast technology

The invention relates to medicine, in particular, to the prevention and treatment of computer fatigue syndrome (CSS) or fatigue from cellular SWASS).

The level of technology

Prevention of computer fatigue symptom is called domestic and foreign researchers (O.A. Goldobina, V.A. Trestin, 2002 [Annex 1, item 9]; G.M. Dyukov, 2008 [Annex 1, item 11]; V. Klebanov, 2010 [Annex 1, item 5]; GV Kozlovskaya, L. F. Kremneva, 2012 [Annex 1, item 16]; B.D. Carter, 2005 [Annex 1, p]; W.G. Kronenberger, 2009 [Appendix 1, p] one of the most urgent problems of the present.

The Ministry of health of Russia has officially released guidelines (LN. Sobczyk, 2010 [Annex 1, p]), where on the basis of modern methods of psychological diagnostics provides information about what "computer fatigue syndrome and fatigue from the mobile communication affects every third user. According to local researchers (B.L. Vinokurov, S. Torosian, 2012 [Annex 1, item 6]) today updated the problem of non-pharmacological prevention of chronic fatigue, including development of special use bottled mineral water (labeled with the methodology of its reception, lifts the computer fatigue), and scientific projected circle of the Russian consumer the new rulers of the proposed method of treatment of this syndrome is about 23 million people daily. The above figure is not final, because according to the official statistics of the Russian Federation Ministry of health (V.I. Skvortsova, 2012 [Annex 1, paragraph 24]), the prevalence of fatigue syndrome (73.0 Z) in adults was estimated at 10,000 people (aged 18-49 years 186,37 cases of General and 115,62 cases primary disease) on the background of the fact that among the child and adolescent population of Russia (from 7 to 17 years) in 2012, a similar incidence per 10,000 person was 791,25 cases, and primary morbidity reached 318,46 cases".

According to S.N. Mamishev and N.P. Gorelova (2003 [Annex 1, paragraph 20]), "effects of prolonged computer work was (68-73%) headaches, memory loss, sleep disturbance, morning tension and generalized weakness. At the same time, in their research, GV Tavern (2006 [Appendix 1, 14]), in addition to these clinics, patients with the syndrome computer fatigue, notes (the duration of the disease from 3 to 5 years) "the emergence of painful lymph nodes and even the appearance of evening fever amid myalgia". As noted by M. Yusupov (2009 [Appendix 1, item 30]) "lymph node enlargement should be seen as a consequence of a General deformation of immune and biochemical status of patients with the syndrome computer fatigue that requires constant monitoring from either the performance FLOOR and responses in the antioxidant defense system (AOD)".

In this period, domestic researchers (NN. Shangina, 2007 [Appendix 1, p, clause 29]); E, Escapisim, 2011 [Annex 1, item 23]); MV Nikitin, 2012 [Annex 1, item 21]) use methods and means of treatment of computer fatigue syndrome, including:

- optimal optical correction spectacles or contact lenses for computer use;

- pharmacotherapy - prescribed vitamins for the eyes, as well as special drops, moistening the cornea and removes the sense of fatigue and dryness of the eyes;

- physical therapy: laser therapy, color therapy, electrotherapy, magnetotherapy, etc.

Own analytical review of relevant scientific publications raised the issue allowed the comparison of positive and negative consequences of the excessive enthusiasm of researchers number of foreign and domestic science schools only drug treatment regimens for patients with fatigue caused by prolonged computer work, and abuse duration of sessions (for a total of more than 3 hours per day) cellular communication, as shown in table 1.

Table 1
Information about the methods of pharmacological and non-pharmacological correction of the syndrome computer is fatigue.
The content of the official thematic publications in leading scientific schools:Interpretation of other authors sanatorium treatment of patients with computer fatigue:
1. Scheme pharmacokineti dyslipidemia (statins, fibrates or nicotinic acid gradually increase the daily dose to 3 g in the tech. months) by E.A. Walker (2005).1.1. Immunostimulating therapeutic effect as aeroionotherapy in combination with UHF-therapy reflexogenic zones Zakharyin-Ged (scheme NN. Longineu, 2007).
2. The use of pharmacotherapy antiaggregatory (pentoxifylline) and cerebral vasodilators (Cinnarizine) for prevention (A.V. Smulevich, 2007) deformation index of cerebral vascular resistance in a computer-based2.1. The decrease in the intensity of the manifestations of parasympathicotonia and the increased tolerance to physiological loads during low-frequency magnetotherapy sympathetic nodes on the dual unit "Magnet-Medeco" (EVGENIY Nut, 2006).

Basic research scientists Sochi research Center of balneology and physiotherapy, as well as the Sochi Institute of neuroactive and vosstanovitelem the th medicine (I.A. Balabanova, 2002 [Annex 1, p.2]; VV Bartashevich, 2006 [Annex 1, section 3]; B.A. Ermakov, 2007 [Annex 1, section 12]; GD Ibadova, 2008 [Annex 1, item 13]; AV Krinichanskii, 2010 [Annex 1, p.19] and others) identified the common clinical manifestations of computer fatigue syndrome (MCS) syndrome and fatigue from cellular SWASS), where prevalent symptoms:

1) headache, dizziness, tinnitus;

2) sleep disturbance, subjective feelings of fatigue;

3) reduction of memory.

One of the main areas of compensation elevated cerebral vascular resistance that occurs in both adults and children in the form of a reactive response to negative factors of computer effects caused by the prolonged work at the computer, had previously been medicated way of antiaggregative, i.e. prevention bonding (adhesion) of platelets to each other (including the use of pentoxifylline). Similar pharmacotherapy were actively promoted not only Ukrainian and Belarusian researchers (EV Korsun, 2005 [Annex 1, p]; A.V. Smulevich, 2007 [Appendix 1, 25]), but was supported by the Russian scientific schools (A.G. Galyamov, 2005 [Annex 1, section 8]). However, there were other (less successful) scientific direction of Russian schools physiotherapists actively publishing own the surveys (V.L. Kokorin, 2004 [Appendix 1, 17]; EVGENIY Smith, 2006 [Appendix 1, p.22]), where the decrease in the intensity of the manifestations of parasympathicotonia (i.e. a sharp increase in tone of the parasympathetic nervous system) in conjunction with increased tolerance to physiological stress was demonstrated using a low-frequency magnetotherapy sympathetic nodes on the dual unit "Magnet-Medeco".

The known method of prevention of computer fatigue syndrome called "Points Professor Pankov, where the light pulses emitted by the device, improve the blood circulation within the eye and stimulate drainage of eye fluid. Take this stimulant-BAD, patented under the name of "Balm Pankov, is an extract of Siberian herbs and various trace elements (see http://pankovmedikl.ru/Kompjuternaja-bolezn-glaza-a-13.html).

For the prevention and treatment of diseases associated with fatigue syndrome (specifically, chronic fatigue syndrome) have been developed and used methods of rehabilitation therapy of patients with CFS on the resort to ingestion of natural mineral waters. For example, known methods of treatment of CFS patent FGI "Pyatigorsk, GNIIT FMBA of Russia: No. 2305570 (2007.09.10) Method of treatment of patients with chronic fatigue syndrome [1]; No. 2256456 (2005.07.20) Method of correction of violations of adaptation in ill the x chronic fatigue syndrome [2]; No. 2406525 (2010.12.20) a Method of treating chronic fatigue syndrome (options) [3].

The above methods of treatment of computer fatigue syndrome does not include use for ingestion halogenated natural mineral waters resort of Sochi.

The mechanism of action of halogenated natural mineral waters is based on the ability of monovalent fluorine content in the chemical formula, for example, natural mineral water "lasarevskoye healing" reaches as a specific component of 3.5 mg/l in the total mineralization called water 5,9-6,1 mg/l, more actively than traditional medical schemes to optimize not only the oxygen saturation level of blood in the microcirculatory level circulation, but also to positively influence the difference of the optical properties of hemoglobin fractions contained in the tested blood volume (1 ml) patients with the syndrome computer fatigue syndrome and fatigue from cellular.

When this sensing derma laser source domestic analyzer LACC-02 (at wavelengths of radiation, the green part of the spectrum of 0.53 μm and the red part of the spectrum of 0.65 μm) in the framework of the optical tissue oximetry (GR), revealed a normalization index specific oxygen saturation of blood in the small venules, arterioles and capillaries of the skin izuchaemoj the contingent of patients from the main group observations (1,64±0,17 used when entering resorts to 2,39±0,08 at discharge from these same resorts). Note that the norm of this indicator varies in healthy individuals in the range of 2.3-2.5 usled [Annex 1.1].

On the basis of a mechanism to increase the oxygen saturation of the blood by the author for the first time the influence of drinking balneotherapy using mineralized hydrocarbonate-chloride sodium, alkaline, boric, with a high content of magnesium, iodine and fluoride in natural mineral water "lasarevskoye healing" wells No. 11-M field "Saloniki" and well No. 84-M Volkonsky field of Sochi (see "lasarevskoye" according to GOST R 54316-2011. Water natural mineral drinking. General specifications).

Prototype by the present invention no. The analysis of the problem and the data of their own research allowed the author to conclude whether treatment of the syndrome computer fatigue syndrome and fatigue from cellular communication to achieve high therapeutic effect claimed by way of drinking balneotherapy using natural mineral water "lasarevskoye healing".

The technical result

The technical result achieved by the claimed invention is to improve health outcomes, i.e. withdrawal headache, dizziness, tinnitus, h is WSTA fatigue, improved sleep, improved memory. Also the technical result is the fact that as a result of using the above copyright complex rehabilitation procedures 64,6% of adults (n=181, p<0.05) and 68.9% of the minors (n=193, p<0,05) from the main group at discharge from the health centers were classified as "healthy" according to the dynamics of their clinical and functional and laboratory values.

The essence of the invention.

The technical result is achieved by a method of prevention and treatment of the syndrome computer fatigue syndrome and fatigue from cellular communication includes the use of mineralized hydrocarbonate-chloride sodium, alkaline, boric, with a high content of magnesium, iodine and fluoride in natural mineral water "lasarevskoye healing" wells No. 11-M field "Saloniki" and well No. 84-M Volkonsky field of Sochi as follows: for 17-19 minutes before eating large gulps, six times a day, every day at 170-190 ml at t°=(23-24°C), for at least 24-30 days, with repeat treatment every three months for three years. The method includes the daily use of mineral water at 8.00, 10.00, 12.00, 14.00, 16.00, 18.00 hours.

Disclosure of the invention.

The inventive method includes scientifically based balneotherapy methods correct and consequences of generalized fatigue (R 53 ICD-X) for individuals abusers duration of sessions cellular (for a total of more than 3 hours per day) or forced to undergo a computer to effect more than 5 hours a day in an employment or academic employment.

Leading from these clinical manifestations are headache, dizziness, tinnitus, insomnia (especially phase of sleep), memory loss, subjective feeling sharp physical fatigue and psychological distress bordering on apathy (see below table 3).

The inventive method for the prevention and treatment of patients with the syndrome computer fatigue syndrome and fatigue from cellular communication includes the use of bicarbonate-sodium chloride, alkaline, boric, with a high content of magnesium, iodine and fluoride in natural mineral water "lasarevskoye healing" wells No. 11-M field "Saloniki" and well No. 84-M Volkonsky field of Sochi as follows: for 17-19 minutes before eating large gulps, 6 times a day, i.e. in 8-10-12-14-16-18 hours daily 170-190 ml at t°=(23-24)°C., the exchange rate is not less 24-30 days required repeat treatment on a quarterly basis within 3 years.

Drinking mineral water with the trade name "lasarevskoye healing" refers to waters with low mineralization Volkonsky mineral medical-table water "Lazarevski what I" and is extracted from the sources:

a) well No. 11-M Saloniki: (mineral water of low salinity, bicarbonate-sodium chloride, alkaline, boric, with a high content of fluorine);

b) well No. 84-M Volkonka: mineral water of low salinity, bicarbonate-sodium chloride, alkaline, boric, with a high fluorine content.

The formula of the ionic composition and other characteristics of the water are shown in table 2.

Table 2
No. SLE.Name of state registration and trade nameThe formula of the ionic compositionSpecificity, mg/DM3FLOW rate, m3/dUse
No. 11-M of Thessaloniki"Lasarevskoye healing"M2,6Cl70(HCO3-+CO32-)29Na99pH9,1H3BO3 310The filling plants, of the hospital (for General bathing, drinking, and local procedures).
150,8
F3 0
No. 84-M Volkonka"Lasarevskoye healing"M4,2Cl76(HCO3-+CO32-)23Na99pH8,7H3BO3569,5
274,4
F3,5

The content of Halogens (fluorine) in the chemical formula of natural mineral water "lasarevskoye healing" reaches as a specific component of 3.0-3.5 mg/l in the total mineralization called water 5,9-6,1 mg/l).

As mentioned above, the mechanism of action of halogenated natural mineral waters is based on the ability of monovalent fluorine more actively than traditional medical schemes to optimize not only the oxygen saturation level of blood in the microcirculation frame link guides the circulation, but also have a positive influence on the difference of the optical properties of hemoglobin fractions contained in the tested blood volume (1 ml) patients with the syndrome computer fatigue syndrome and fatigue from the provider.

The Federal service for supervision of consumer rights protection and human welfare (Rospotrebnadzor), signed by the chief sanitary doctor, Onishchenko issued a Certificate of state registration №U from 01.11.2006 that water mineral dining room "lasarevskoye healing" (THE 9185-002-95093915-06) passed the state registration, registered in the State register and approved for production on the territory of the Russian Federation, import and circulation on the territory of the Russian Federation (Annex 2). This certificate is issued on the basis of balneological conclusions SIC balneology and rehabilitation of the black sea zone control of specialized sanatorium of Ministry from 08.08.06, No. 75, Protocol ATL RDC "Quality" (№ ROSS RU.0001.2117) from 01.08.06, No. 1290. The validity of the certificate of state registration is set by the CPS for the entire period of the industrial production of Russian production or supply of imported goods (number of the certificate 0037130).

In addition, the Federal service for supervision in the sphere of protection of consumer rights is spruce and well-being on the water mineral table "lasarevskoye healing" (THE 9185-002-95093915-06) issued by the Sanitary-epidemiological conclusion No. T from 01.11.2006, on the compliance of this mineral table water of the state sanitary-epidemiological rules and norms SanPiN 2.3.2. 1078-01 "Hygienic requirements for safety and nutrition value of food products". This Sanitary-epidemiological conclusion is also signed by the head of Rospotrebnadzor, Onishchenko (Annex 3).

Using the proposed method with the specified modes drinking balneotherapy allowed to stop (in a period from 30 to 40 days of continuous reception) main manifestations of the syndrome computer fatigue syndrome and fatigue from a cellular connection, when the leading of these clinical manifestations were originally headaches, dizziness, tinnitus, insomnia (especially phase of sleep), memory loss, subjective feeling sharp physical fatigue and psychological distress bordering on apathy.

In addition, the claimed method at a statistically significant level observations (n=560, p<0,05) contributes to the positive dynamics of the kinetic tests and tests on mental health in conjunction with optimization of parameters of echoencephalography (table 4).

Regular use of the above methods of treatment of drinking natural mineral water "lasarevskoye healing" is in the form of innovation is echnology balneoprophylaxis myopia and hypermetropia in adults and children with a high degree of computer addiction or fatigue from cellular. The resulting component of this technology was normalization of ophthalmologist eyes, usually falling on 60-70% during prolonged work at the computer (table 5). The proposed method allows prophylaxis is observed at 68-72% of patients with the syndrome computer fatigue syndrome and fatigue from cellular the following clinical manifestations:

1) destabilization of the indicators of lipid peroxidation and blood rheological properties (table 6);

2) deformation characteristics of cerebral hemodynamics in contingency with the fall of the phagocytic activity of neutrophils in peripheral blood (table 7).

Illustration of therapeutic effectiveness of the proposed method is the fact that as a result of using the above copyright complex rehabilitation procedures 64,6% of adults (n=181, p<0.05) and 68.9% of the minors (n=193, p<0,05) from the main group at discharge from the health centers were classified as "healthy" according to the dynamics of their clinical and functional and laboratory parameters. In the control group where patients were treated on the same database research (CJSC "Sanatorium "lasarevskoye" (354200, Russia, Krasnodar region, Sochi, Sochi highway 6; the act of implementation No. 37 dated 23.01.2013); resort to them. N.A. Semashko health Ministry (354200, Russia, Sochi, Lazarevsky district, Uch-Dere; the act is nagrania No. 20 dated 22.01.2013); CJSC "Sanatorium "starfish" (354200, Russia, Sochi, Lazarevsky district, Pobeda str., 15; the act of implementation No. 98 dated 22.01.2013) standard therapies, i.e. without the use of natural mineral water "lasarevskoye healing", the number of healthy (both among adults and among children) were at discharge from resorts 2.1 times less than that presented in table 7.

Sick of the SSI and SWASS was observed on three bases of the study. These bases of the study was three large resort Lazarevskoye recreation area Kuban, namely:

1) closed joint stock company "Sanatorium "starfish";

2) CJSC "Sanatorium "lasarevskoye";

3) children's sanatorium. N.A. Semashko health Ministry of the Russian Federation.

As the observation units were formed (during unintentional selection in the above resorts):

a) the main group of units of observation (n=560);

b) control group (n=560).

In each group of observations 50% (n=280) were adults aged 18-29 years, and 50% were children and adolescents of school age from 7 to 17 years (n=280). Characteristics of professional work (as selected as observation units adults were programmers, clerks-clerks, employees of large accounts, etc.) made these rabotaushi the individuals to conduct a computer to 6 hours per day. Observe the children and adolescents of school age (due to the performance of educational tasks or gaming computer addiction) held computers (according to data medico-sociological survey) 1.3 times more than adults surveyed, i.e. an average of 7.5 hours a day. In observation groups was 50% of men (boys) and 50% of women (girls).

To determine the functional status of patients with SSI and SWASS used step rating scale with standardized criteria for assessing the severity of each subjective symptom, and the sample Schulte mental performance using 5 standard tables. As kinetic samples used:

a) three passes - I finger the patient alternately touched II, III, IV and V fingers of the same hand, and then sorted through them in reverse order, starting with the fifth finger; when this was recorded, the time during which he managed to make three complete enumeration;

b) number of compressions of the brush 10 with each hand.

Called the assessment of neurological and physiological status of patients with the syndrome computer fatigue complemented by indicators of cerebral blood flow through the major arteries of the head on the basis of the ultrasonic Doppler (USDG) using domestic computerized echoencephalography the FA EHEDG-Complex-M and transcranial Doppler (TKD), pursued by a modified domestic methodology (BV Gaidar et al., 2004 [Annex 1, item 7]) with the location of the carotid arteries in the neck, middle, anterior, and posterior cerebral arteries, vertebral and main arteries. Estimated systolic, diastolic and average linear velocity of blood flow. Expected rate of peripheral resistance - pulsatile index Gosling (PI). To assess vasodi-etalonnage reserve (CR+) used a sample of breath, vasoconstrictor (Kr) - sample with hyperventilation. Calculate the index of vasomotor reactivity (IVMR), which is the integral index of cerebrovascular adaptation. To verify the extent of temporary vascular microsemi local areas of the cerebral cortex was performed MRI apparatus Somaton Emotion "Siemens" with a field strength of 0.2 Tesla. When morphometrics was determined by the width of the third ventricle at the level of the holes Monroe, lateral ventricles at the level of the anterior horns in transmisores and coronal planes, width silvamix furrows. The rheological properties of blood were assessed by indicators:

1) blood viscosity (VK), determined on capillary and rotational (ARC-2) viscometers (units VK - SP - antipapal);

2) hematocrit (HT) modified A.G. Amyntaio and co-authors of the methodology;

3) the content of fibrin the gene (FG), which dry air was investigated by the method according to R.A. Rutberg;

4) platelet aggregation is determined by the method G.Born, advanced J.O''brien when exposed to ADP and epinephrine;

5) the values of prothrombin index;

6) fibrinolytic activity (FA) blood and index of fibrinolysis (if) according to method E. Bidwell.

Cerebral hemodynamics was studied using the REG on the rheography brand 4-RG-1, is connected to the ECG recording was performed in frontolateral and occipitomastoid leads. Along with the visual characteristic eographically curves were performed quantitative analysis by the method of I.V. Sokolova. This was determined by the following parameters: the amplitude of the arterial components (A), a measure of peripheral vascular resistance (V/a), the rate of venous outflow (VO), asymmetry factor (KA). To assess the standard of EEG parameters in this study were used encephalograph brand AAGP 4-02 monitor THEM-789. Electroencephalography was performed in the state of quiet wakefulness (8 regions of the brain with the arrangement of the electrodes according to the international scheme 10-20: O2-A2, P4-A2, C4-A2, F4-A2, O1-A1 P3-A1, C3-A1, F3-A1). For the analysis used a 60-second bitartarate fragments of EEG, which was calculated spectra of absolute power in the range of 0.5 to 30.0 Hz increments of quantization of 0.4 Hz. While Oprah is the bookmark spectral characteristics applied the fast Fourier transform and a smoothing window Kaiser-Bessel. Within the presented study investigated the dynamics of processes of lipid peroxidation (LPO) and comparison of this indicator with the characteristic index of antioxidant activity (AOA) according to the method M.V. Bilenko (2001 [Annex 1, section 5]) and activity of ceruloplasmin in plasma by the method of SV Bestuzhev and VG Bulb (2002 [Annex 1, p.4]). To control for restorative treatment of the observed group of patients was studied phagocytic activity of neutrophils in the peripheral blood in the calculations (by the method V.V. Menshikov) the following phagocytosis indices: phagocytic index, opsonic index, absorption coefficient phagocytic number, index bactericides neutrophils, etc. determine the level of electric ophthalmologist (E) of the patient, conducting a computer for 6 hours or more, conducted when applying electrode domestic apparatus "3COM" to the temporal point of the century closed right eye, depending on the individual reaction of the patient at the time of flicker fusion of Fofana. A study of the critical frequency of flicker fusion (as a test professional activity of the visual analyzer) was performed using methods C.V. Golubtsova (2002 [Annex 1, paragraph 10]). Quantitative data were processed by the method of variation statistics with the definition: medium arithmet the ical (the difference was considered significant at p< 0,05); the materiality of differences and correlation coefficient Spearman rank on the IBM computer operating in the Windows environment using Microsoft Excel.

Treatment of patients with the syndrome computer fatigue and tiredness from cellular included the above method of assigning treatments drinking balneotherapy using bicarbonate-sodium chloride, alkaline, boric, with a high content of magnesium, iodine and fluoride in natural mineral water "lasarevskoye healing" wells No. 11-M field "Saloniki" and well No. 84-M Volkonsky field of Sochi by the following method: for 17-19 minutes before eating large gulps, 6 times a day, i.e. in 8-10-12-14-16-18 hours daily 170-190 ml at t°=23-24°C.

Taken into account that under the national Standard GOST R 54316-2011(natural mineral Water drinking) this mineral mineralization 5,0-6,0 g/DM3water does not imply limitations in daily and course doses consumption, and in the composition of its biologically active components present in industrial concentrations ions of boron, magnesium and fluoride.

Patients in the control group observations (both adults and children) during their stay in the resorts-bases research drinking balneotherapy has been used, and as outdoor hydrotherapy used standard pearl baths is based on sea water. Physiotherapeutic effect control group of patients was carried out using the procedures of electrosleep and transcerebral amplipulse therapy at the standard orbital and occipital method.

79±5
Table 3
Characteristics of neurological status (p<0,05)The main group (n=560)Control group (n=560)
before the treatmentafterbefore the treatmentafter
1. Headache, dizziness, tinnitus275±242±6271±394±4
263±435±3257±275±2
2. Sleep disturbance, subjective sense of tiredness279±129±2273±163±3
276±238±4269±1
3. Complaints about memory loss95,4% (267)10,7% (30)94,6% (265)30,3% (85)
of 92.9% (260)9,6% (27)to 92.1% (258)27,8% (78)

Note. Here and below: in the numerator adults (n=280); the denominator of the children (n=280). One patient was able to report two or more symptoms of computer fatigue.

Table 3 gives the comparison of the results of treatment of patients with fatigue due to prolonged work at a computer or fatigue from cellular (R 53 ICD-X) by the present method (Main group) and by well-known methods (Control group). As can be seen from table 3, the result of treatment by the present method more efficient than the traditional method of rehabilitation treatment in health resorts patients with the syndrome computer fatigue.

This is confirmed by the following result: if you enroll in a health database research among patients and control group observations (both adults and children) noted a significant percentage of persons suffering from headache, dizziness, tinnitus (96-98% of the total number of observations), PEFC is the implementation of the treatment by the present method similar symptoms (adults from the main group of observations has decreased by 6.5 times, and children have a 7.5 times. Even more convincing are the results of the survey, showing the relief of complaints about memory loss (due to computer tiredness or fatigue from provider), because after the completion of treatment by the present method similar symptoms were seen in only 10.7% of adults and 9.6% of children, although on arrival at the resort similar complaints were expressed by 95.4% of adults and 92.9% of children. Result result of all the above indicators was 1.5-2.1 times worse than patients of the control group treated in the same resorts, but according to traditional methods.

Table 4 shows the results of a study of the correction of the degree of fatigue during work or school employment in persons treated by the present method (main group)and traditional method (control group). This is confirmed by the fact that the samples Schulte, initially increased 1.4 times (compared to normal) in patients of both groups of observations decreased to the optimal values only in patients of the main group. In the control group similar physiological characteristics prior to the discharge of the resorts have continued to exceed the normal value of the sample Schulte and kinetics of samples 3 passes fingers (test correction generalized fatigue) in 1,2 times. This is about what was aktivizirovalasj indicators echoencephalography, when the index of vasomotor reactivity (together with dynamics 60-second bitartarate fragments EEG) normalized nearly 70% of patients from the main group observations, not even reaching the upper limit of normal in patients from the control group. Similar dynamics of indicators of the level of vasoconstrictor and vasodilatation reserve validly registered on the national computerized echoencephalography that simultaneously determine the pulsatile index Gosling and average linear velocity of blood flow.

54±5
Table 4
Figure (p<0,05)The main gr. (n=560)Control gr. (n=560)
before the treatmentafterbefore the treatmentafter
1. The dynamics of the kinetic tests and tests for mental capacity
Indicators sample Schulte on mental health (N=36-39)51±237±250±344±2
39±152±246±1
The kinetics of the samples three passes of fingers (N=10-11)27±411±226±518±1
29±612±228±318±2
2. Computerized performance echoencephalography:
Pulsatile index Gosling (PI), N=0,27-0,290,62±0,070,28±0,020,61±0,040,34±0,03
0,59±0,030,29±0,010,60±0,060,37±0,05
Assessment vasodilatation reserve breath (Cu+), N=67-69%51,7 (145)67,5 (189)51,4 (144)57,8 (162)
52,8 (148)66,0 (185)52,5 (147)57,1 (160)
Evaluation vasoconstric ktorego reserve hyperventilation (Kr-), N=34-37%26,7 (75)36,8 (103)27,1 (76)31,7 (89)
26,4 (74)26,0 (101)26,0 (73)30,7 (86)
An index of vasomotor reactivity (IVMR), N=69-71%53,9(151)69,6 (195)53,5 (150)59,6 (167)
53,2 (149)69,2 (194)52,8 (148)60,0 (168)
Dynamics 60-seconds bitartarate fragments EEG, N α-rhythm=9,0-10,2 Hz8,4±0,29,5±0,48,5±0,18,8±0,1
8,1±0,39,3±0,18,1±0,28,6±0,2
The average linear velocity of blood flow, N=67-68 cm/s64,02±0,0967,34±0,0364,13±0,0565,44±0,02
63,83±0,0467,21±0,0263,98±0,03 65,27±0,01

N=1,57-1,58 mm
Table 5
The effectiveness of balneotherapy event (P<0,05)The main group (n=560)Control gr. (n=560)
before the treatmentafterbefore the treatmentafter
1. Ophthalmologist81,4% (228)11,4% (32)80,7% (226)29,3% (82)
eyes when working on the computer decreases84,6% (237)12,5% (35)83,2% (233)32,5% (91)
2. A positive test for frequency of merge test flickering33,9% (95)89,6% (251)34,6% (97)67,8% (190)
35,3% (99)95,7% (268)35,7% (100)71,7% (201)
3. P is a positive test for attention and spatial orientation 28,2% (79)94,2% (264)28,9% (81)78,2% (219)
27,1% (76)to 92.1% (258)27,8% (78)73,2% (205)
Change of parameters of magnetic resonance imaging brain patients:
The width of the third ventricle0,53±0,010,42±0,010,50±0,020,47±0,01
N=0,40-0,42 mm0,51±0,020,42±0,020,51±0,020,46±0,01
The lateral ventricle on the right1,65±0,021,61±0,011,66±0,021,64±0,01
N=1,60-1,62 mm1,64±0,011,61±0,021,64±0,011,64±0,01
The lateral ventricle on the left1,67±0,021,58±0,011,67±0,011,61±0,01
1,68±0,011,57±0,021,68±0,021,62±0,01
The width of silvaloy furrow to the right, N=0,62-0.64 mm0,69±0,020,63±0,020,69±0,020,67±0,01
0,68±0,010,61±0,02of 0.66±0.010,65±0,01
The width of silvaloy furrows left, N=0,71-0,73 mm0,76±0,020,72±0,010,75±0,020,74±0,01
0,76±0,010,71±0,010,76±0,020,74±0,01

According to table 5 follows the direct correlation of the indicators of the level of electrical ophthalmologist and tests of professional activity of the visual analyzer with changes in magnetic resonance imaging of brain in children and adolescents with a high degree of computer addiction or fatigue from cellular. In this regard, a positive test for frequency of merge test blinks (initially reduce the Naya in both groups of observations to the level of 33-35%) achieved at discharge from resorts in patients of the main group 89,6% (children 95,7%), keep adults from the control group at the level 67,8% and 71.7% for minors.

The results of the study are summarized in table 6, indicate the ability to use natural mineral water "lasarevskoye healing" for normalization of lipid peroxidation (LPO). It States the fact that the content of ceruloplasmin in the blood plasma of patients with the syndrome computer fatigue from the main group of observations was at an extract from a database of research-level 2B,98±0.23 mg % in adults and 2B,71±0.18 mg % in children, although the treatment of these patients called the figure was more than 30 mg % (N=26-27 mg %).

Table 6
Clinical and laboratory characteristics (p<0,05)The main group (n=560)Control gr. (n=560)
before the treatmentafterbefore the treatmentafter
Blood plasma:
ceruloplasmin, mg % (N=26-27)30,85±0,64 26,98±0,2330,76±0,4428,82±0,11
a 30.39±0,5626,71±0,1830,27±0,1228,51±0,13
FLOOR, E=232/220 (usld):
heptane phase (N=0,77-0,79)0,96±0,080,78±0,020,92±0,060,84±0,01
0,95±0,040,77±0,010,90±0,050,86±0,02
isopropanolate phase0,48±0,050,38±0,010,47±0,030,43±0,01
(N=0,36-0,38)0,47±0,020,37±0,020,46±0,020,42±0,02
State rheological and coagulation properties of blood in a computer-based fatigue:
The content of fibrinogen by the method of R.A. Rutberg, N=2.0 to 2.4 g/l 3,6±0,42,3±0,13,5±0,22,9±0,2
3,4±0,22,2±0,13,4±0,12,8±0,1
The hematocrit (Ht,%),45,8±0,740,5±0,345,9±0,642,2±0,3
N=40,4 of 40.845,2±0,540,6±0,145,1±0,442,1±0,2
Platelet aggregation according to the method of G. Born with adrenaline, N=41,3 of 41.647,6±0,341,4±0,247,4±0,543,0±0,6
47,5±0,441,5±0,247,3±0,342,9±0,1

The same factor, i.e. the recommended drinking according to the invention the appointment of the natural mineral water "lasarevskoye healing" was a factor in compensation patients of the main group viewers the deposits initially deformed rheological and coagulation properties of blood. The content of fibrinogen in the blood plasma and the level of platelet aggregation significantly elevated at admission on the basis of the study, were restored upon completion of the above copyright schemes sanatorium rehabilitation, while standard approaches to treatment in health resorts of the same group of patients managed in the control group observations) only identify trends to improve the mentioned biochemical characteristics.

The study presents statistically significant evidence (table 7) the effectiveness of the proposed method in the study of health outcomes in different age groups of the population with the syndrome computer fatigue or tiredness from cellular. You should pay attention to the dependence of the characteristics of the REG-cerebral hemodynamics and intensity of application of the developed methods for the treatment of SSI and SWASS. Illustration of therapeutic effectiveness of the proposed method compared with the traditional serve as comparative data recovery schemes physiological constants in adults and children, vulnerable to computer fatigue syndrome and the syndrome of fatigue from cellular (R 53 ICD-X), are given in table 7.

no
Table 7
Physiological constants (p<0,05)The main group (n=560)Control gr. (n=560)
before the treatmentafterbefore the treatmentafter
Leading characteristics of cerebral hemodynamics in adults with the syndrome computer fatigue
(*frontolateral and **occipitomastoid REG - derivations):
Indicator of peripheral vascular resistance (And %)57,2±0,4*to 91.1±0,6*57,9±0,8*69,7±0,2*
58,2±0,3**93,5±0,2**58,6±0,5**70,9±0,1**
The amplitude of the arterial components (A, Ω)was 0.138±0,03*rate £ 0.162±0,01*0,137±0,04*0,150±0,02*
0,141±0,02**0,164±0,01**0,143±0,02**0,151±0,01*
The ratio of cerebral asymmetry (KA %)36,7±1,2*24,4±0,6*36,4±0,9*30,5±0,2*
29,2±1,0**19,1±0,2**29,0±0,3**24,7±0,2**
Optimization of phagocytic activity of neutrophils in peripheral blood:
Phagocytic index, 120 minutes incubation (N=90-92%)96,4±0,291,5±0,296,2±0,1to 94.3±0,2
to 96.8±0,4the 90.8±0,396,7±0,294,0±0,1
Index bactericides neutrophils (N=66-68%)76,5±0,666,9±0,576,8±0,471,7±0,1
76,3±0,266,4±0,276,6±0,370,8±0,2
Criteria.list objective health outcomes at discharge from health centers:
Healthy64,6% (181)no30,7% (86)
68,9% (193)31,4% (88)
Improvement31,1% (87)of 58.9% (165)
25,7% (72)57,5% (161)
Without improvements4,3% (12)10,4% (29)
5,4% (15)11,1% (31)

As can be seen from table 7, the peripheral vascular resistance, the amplitude of the blood components and the ratio of cerebral asymmetry exceeded 1.3-1.4 times in the main group of the study is similar to rates in patients from the control group. Moreover, patients from the main group of observation the recommended technology for treatment of drinking natural mineral water "lasarevskoye healing" was the base ingredient of non-pharmacological normalization of the characteristics of non-specific immunity, including the index bactericides neutrophils, as one of the CL the clinical manifestations of the syndrome computer fatigue syndrome and fatigue from cellular. In the control group the same indicator had only a tendency to optimization. The result of the proposed method can be considered as the following: 64,6% of adults (n=181, p<0.05) and 68.9% of the minors (n=193, p<0,05) from the main group at discharge from the health centers were classified as "healthy" according to the dynamics of their clinical and functional and laboratory parameters. In the control group the number of healthy (both among adults and among children) were at discharge from health centers - research databases, which were three large resort Lazarevskoye recreation area Kuban, namely: 1) closed joint stock company "Sanatorium "starfish"; 2) CJSC "Sanatorium "lasarevskoye"; 3) children's sanatorium. N.A. Semashko health Ministry of the Russian Federation, 2.1 times less.

Examples of the method.

Example 1. Patient Micah minerals, 32, and/b No. 781, was treated at CJSC "Sanatorium "lasarevskoye" (354200, Russia, Krasnodar region, Sochi, Sochi highway 6) 03.12.2012 on 27.12.2012. Diagnosis on arrival at the sanatorium map: computer fatigue syndrome associated with professional activities. Over 10 years working as a programmer in a large Krasnodar firm producing product for distance learning students of technical universities. In the last 5 years she is : a headache, dizziness, tinnitus, insomnia (especially in the phase of falling asleep). Is in the dispensary in the municipal health care institution of the place of residence in the last 3 years about the syndrome computer (chronic) fatigue. The treatment was carried out using cerebral vasodilators (Cinnarizine), nicotinic acid. Also used the method as aeroionotherapy in combination with UHF-therapy reflexion Zakharyin-Ged by the classical scheme NN. Longineu (2007). In the absence of planned therapeutic effect was sent to the municipal health care institution Krasnodar on the course of balneotherapy in CJSC "Sanatorium "lasarevskoye" (Sochi). On arrival he complained of headache, dizziness, tinnitus, subjective sense of tiredness and memory loss. Objectively: the patient is a proper physique, thin (height 176 cm has a weight of 68.3 kg). The vesicular breathing, wheezing no. Heart sounds rhythmic, somewhat muted. Percutere: the borders of relative heart dullness in normal, wet tongue coated whitish bloom. The abdomen is soft, painless. Percutere border of the liver on the edge of the costal arch. Chair - irregular (the tendency to constipation). Urination free, painless, Newcastle. Symptom PA is ternasco negative on both sides. Urine color is straw-yellow.

Laboratory tests: complete blood count - hemoglobin 134 g/l, CVP,9, platelets 210×109the leukocytes of 5.4×109, EOS. 3, PAL. 1, segm. 73, limp. 26, mon. 8, ESR 15 mm/h; absence - tank weight 1012, transp. full reacts. sour, no protein, no sugar, an epithelium flat, small Qty, leukocytes 2-4 p/TREN., no mucus.

Kinetic tests and tests on mental health: 1) sample Schulte 51±2 when N=36-39; 2) the kinetics of the samples of the three passes of the fingers 27±4 when N=10-11 C.

Computerized performance echoencephalography: pulsatile index Gosling (PI), and 0.62±0,07 when N=0,27-0,29 (PI); an index of vasomotor reactivity (IVMR), 53,9% when N=(69-71)%; dynamics of 60 seconds. bitartarate fragments EEG=8,4±0.2 Hz for N α-rhythm =(from 9.0 to 10.2) Hz.

Clinical and laboratory characteristics: GENDER, E=232/220 (used): - heptane phase 0,96±0,08 when N=0,77-0,79); - isopropanolate phase of 0.48±0.05 at N=0,36-0,38. Platelet aggregation according to the method of G. Born with adrenaline, 47,6±0,3 N=41,3 of 41.6 g/l Indicator of peripheral vascular resistance (V/a, %): frontolateral REG - derivations 57,2±0,4%; occipitomastoid REG - leads to 58.2 ą 0.3. Index bactericides neutrophils 76,5±0.6 N=(66-68)%.

According to history, clinical, laboratory, instrumental and functional studies for admission to the sanatorium diagnosed with si the drôme computer fatigue, marked clinical course on the background of the decrease of the kinetic tests and tests for mental capacity. Clinical and functional deformity (deterioration) indicators of echoencephalography, characteristics, GENDER, cerebral hemodynamics, blood rheological properties and index bactericides neutrophils.

Assigned treatment method: gently-training mode of physical activity, indifferent air baths (each=21-23C°) mode sebadinamita, free swimming in the waters of the sea of medical beach duration 3-5-7 minute on the rise when the water temperature t=23°C and above. Modes drinking balneotherapy using bicarbonate-sodium chloride, alkaline, boric, with a high content of magnesium, iodine and fluoride in natural mineral water "lasarevskoye healing" wells No. 11-M field "Saloniki" Volkonsky field of Sochi by the following method: for 17 minutes before eating large gulps, 6 times a day, i.e. in 8-10-12-14-16-18 hours a day, in 170 ml at t°=23°C, directional reception 24 days.

As a result of the treatment: normalization of sleep (fall asleep fast, sleep at least 8 hours, sleep is restful, dreamless); headache, dizziness, tinnitus is not noted. Subjective notes the disappearance of forgetfulness on small household episodes, i.e. notes improvement is the memory. Objective: indicators sample Schulte mental performance recovered to 37±2, N=36-39 C. Computerized indicators of echoencephalography: pulsatile index Gosling =0,28±0,02 (PI) for N=0,27-0,29 (PI); an index of vasomotor reactivity (IVMR)=69.6 per cent for N=69-71%; dynamics of 60 seconds. bitartarate fragments EEG=9,5±0,4 Hz when N α-rhythm =(from 9.0 to 10.2) Hz. Clinical and laboratory characteristics: GENDER, E=232/220 (used): - heptane phase was 0.77±0,01 N=0,77-0,79 used; - isopropanolate phase 0,38±0,01 N=0,36-0,38 used platelet Aggregation according to the method of G. Born with epinephrine =41,4±0.2 at N=41,3 of 41.6 g/l Indicator of peripheral vascular resistance (V/a, %): frontolateral REG - leads to 91.1±0,6% when N=(90-92)%; occipitomastoid REG - derivations 93,5±0,2% when N=(93-94)%. Index bactericides neutrophils 66,9±0.5% for N 66-68%. Thus, according to the existing criteria of objective health indicators patient Micah minerals, 32, and/b No. 781, which took place course of treatment in CJSC "Sanatorium "lasarevskoye" (354200, Russia, Krasnodar region, Sochi, Sochi highway 6) 03.12.2012 on 27.12.2012 at discharge from the sanatorium is recognized as healthy. Recommendation - binding repeat treatment every three months for 3 years.

Example 2. Patients To the VA for 23 years, and a/b No. 733 was treated at CJSC "Sanatorium "lasarevskoye" (354200, Russia, Red is Arsk region, Sochi, Sochi highway 6) 29.10.2012 on 21.11.2012. Diagnosis on arrival at the sanatorium map: fatigue syndrome from cellular associated with professional activities. Over the last 4 years working as a Secretary, which (according to the conditions of professional activity) requires it to carry out during the day sessions cellular communication with clients of the firm. The total duration of the talks on the cell phone per day is every day more than 7 hours Complains of headaches, sleep disturbances (especially in the phase of falling asleep), noise in the ears, dizziness. Is for 4 years at the dispensary with a neurologist in the municipal health care institution of the place of residence (Moscow) with the diagnosis of the Syndrome of fatigue from cellular". Treated with medication (statins, fibrates or nicotinic acid gradually increase the daily dose to 3 g in the tech. mon., cerebral vasodilators, including Cinnarizine to prevent deformation index of cerebral vascular resistance in fatigue from the provider). In the absence of planned therapeutic effect was sent to the municipal health care institution Moscow on the course of balneotherapy in CJSC "Sanatorium "lasarevskoye" (Sochi). On arrival he complained of headache, is golovokrugenie, tinnitus, subjective sense of tiredness even when short on time sessions cellular, irritability, social conflict in small domestic disputes, the feeling of mental fatigue bordering on apathy. Objectively: the patient the right physique. In the lungs vesicular breathing, wheezing no. Heart sounds rhythmic, somewhat muted. Percutere: the borders of relative heart dullness within norms, language and wet clean. The abdomen is soft, painless. Percutere border of the liver on the edge of the costal arch. Chair - regular. The consistency and color of the stool is not changed. Urination free, painless, Newcastle. Symptom of Pasternack negative on both sides. Urine color is straw-yellow.

Laboratory tests: complete blood count - hemoglobin 150 g/l, Cup 1,0, platelets 208×109the leukocytes of 5.6×109, EOS. 4, PAL. 1, segm. 68, limp. 23, mon. 6, the sedimentation rate of 14 mm/h; absence - tank weight 1011, transp. full reacts. sour, no protein, no sugar, an epithelium flat, small Qty, leukocytes 2-4 p/TREN., no mucus.

Kinetic tests and tests on mental health: 1) sample Schulte 54±5 N=36-39; 2) the kinetics of the samples of the three passes of the fingers 29±6 when N=10-11 C.

Computerized performance echoencephalography: pulsatile index Gosling (PI), and 0.9±0,03 N=0,27-0,29 (PI); an index of vasomotor reactivity (IVMR), 53.2 per cent for N=69-71%; dynamics of 60 seconds. bitartarate fragments EEG=8,1±0,3 Hz when N α-rhythm =9,0-10,2 Hz.

Clinical and laboratory characteristics: GENDER, E=232/220 (used): - heptane phase of 0.95±0.04 with N=0,77-0,79); - isopropanolate phase of 0.47±0,02 N=0,36-0,38. Platelet aggregation according to the method of G. Born with adrenaline, and 47.5±0,4 N=41,3 of 41.6 g/l Indicator of peripheral vascular resistance (V/a,%): frontolateral REG - derivations 57,9±0,2%; occipitomastoid REG - derivations of 58.6±0,1. Index bactericides neutrophils 76,3±0.2 at N=66-68%.

According to history, clinical, laboratory, instrumental and functional studies for admission to the sanatorium diagnosed fatigue Syndrome from cellular expressed clinical course on the background of the decrease of the kinetic tests and tests for mental capacity. Assigned treatment method: gently-training mode of physical activity, indifferent air baths (eat=21-23°C) mode sebadinamita, free swimming in the waters of the sea of medical beach duration 3-5-7 minute on the rise when the water temperature t=23°C and above. The mode of drinking balneotherapy using bicarbonate-sodium chloride, alkaline, boric, with a high content of magnesium, iodine and fluoride in natural mineral water "Lazare is led healing" wells No. 84-M Volkonsky field of Sochi, according to the following procedure: for 19 minutes before eating large gulps, 6 times a day, i.e. in 8-10-12-14-16-18 hours daily for 190 ml at t°=24°C, course admission within 30 days.

As a result of the treatment: there is positive dynamics of subjective symptoms: no complaints on headache and a feeling of tiredness when talking on cellular communication. Normalization of sleep in all its phases. Kinetic tests and tests on mental health: 1) sample Schulte 37±1 for N=36-39; 2) the kinetics of the samples of the three passes of the fingers 10±1 for N=10-11 C. Computerized indicators of echoencephalography: pulsatile index Gosling =0,29±0,01 (PI) for N=0,27-0,29 (PI); an index of vasomotor reactivity (IVMR)=69,2% when N=69-71%; dynamics of 60 seconds. bitartarate fragments EEG=9,3±0.1 Hz, N α-rhythm =9,0-10,2 Hz. Clinical and laboratory characteristics: GENDER, E=232/220 (used): - heptane phase 0,78±0,01 N=0,77-0,79 used; - isopropanolate phase 0,37±0,02 N=0,36-0,38. used platelet Aggregation method G.Born with epinephrine =41,5±0.2 at N=41,3 of 41.6 g/l Indicator of peripheral vascular resistance (V/a, %): frontolateral REG - derivations of 91.6±0.3% at N=90-92%; occipitomastoid REG - derivations 93,2±0,1% for N=93-94%. Index bactericides neutrophils B6,4±0,1% for N 66-68%. Thus, according to the existing criteria of objective health indicators PA who ienda To the Islands, 23, and a/b No. 733, which took place course of treatment in CJSC "Sanatorium "lasarevskoye" (354200, Russia, Krasnodar region, Sochi, Sochi highway 6) 29.10.2012 on 21.11.2012. on 27.12.2012 at discharge from the sanatorium is recognized as healthy. Recommendation - binding repeat treatment every three months for 3 years.

These data allow us to conclude about the efficiency of the proposed method for the prevention and treatment of computer fatigue syndrome (MCS) syndrome and fatigue from cellular SWASS) using drinking mineral water with the trade name "lasarevskoye healing" resort on the stage. The recommended method can be carried out in an identical mode phase of outpatient treatment of patients with SSI and SWASS in clinics.

SOURCES of INFORMATION

1. RF patent №2305570 (2007.09.10) Method of treatment of patients with chronic fatigue syndrome.

2. RF patent №2256456 (2005.07.20) Method of correction of violations adaptation in patients with chronic fatigue syndrome.

3. RF patent №2406525 (2010.12.20) a Method of treating chronic fatigue syndrome (options).

Appendix 1

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1. Method of prevention and treatment of the syndrome computer fatigue syndrome and fatigue from cellular communication, including ingestion of mineralized hydrocarbonate-chloride sodium, alkaline, boric, with a high content of magnesium, iodine and fluoride is a natural mineral water "lasarevskoye healing" wells No. 11-M field "Saloniki" and well No. 84-M Volkonsky field of Sochi as follows: for 17-19 minutes before eating large SIPS, six times a day, every day at 170-190 ml at a temperature of 23-24°C for at least 24 to 30 days, with repeat treatment every three months for three years.

2. The method according to claim 1, including daily consumption of mineral water at 8.00, 10.00, 12.00, 14.00, 16.00, 18.00 o'clock



 

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26 cl, 60 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to treatment of neurological diseases of central nervous system. Method of treatment of neurological disorder of central nervous system in patient includes introduction of therapeutically active quantities of composition including: a) at least one complex, which includes therapeutic polypeptide and block copolymer, where said block copolymer includes at least one water-soluble non-ionic segment and at least one poly-ionic segment, where said poly-ionic segment includes at least one charge, opposite to charge of therapeutic polypeptide, where said complex has morphology core-shell, where core contains water-soluble non-ionic segment of block copolymer, and where shell contains water-soluble non-ionic segment of block copolymer and b) at least one pharmaceutically acceptable carrier, where said at least one complex penetrates blood-brain barrier. Method of treating neurological disorder of central nervous system in patients includes introduction of therapeutically active quantities of composition including: a) isolated cells, containing at least one complex, which includes therapeutic polypeptide and block copolymer, where said block copolymer includes at least one water-soluble non-ionic segment and at least one poly-ionic segment, where said poly-ionic segment includes at least one charge, opposite to charge of therapeutic polypeptide, where said complex has morphology core-shell, where core contains therapeutic polypeptide and poly-ionic segment of block copolymer and where shell contains water-soluble non-ionic segment of block copolymer, and b) at least one pharmaceutically acceptable carrier, where said cells penetrate blood-brain barrier. Isolated cell, which contains at least one complex, containing at least one protein and block copolymer, where said copolymer includes at least one water-soluble non-ionic segment and at least one poly-ionic segment, where said poly-ionic segment contains at least one charge, opposite to charge of said protein, where said complex has morphology core-shell, where core contains therapeutic polypeptide and poly-ionic segment of bloc copolymer and where shell contains water-soluble non-ionic segment of block copolymer. Composition, containing said isolated cells and at least one pharmaceutically acceptable carrier. Method of protein delivery through blood-brain barrier into central nervous system, including introduction of said composition to subject. Method of protein delivery through blood-brain barrier into central nervous system, including introduction to patient of composition, containing: a) at least one complex, including therapeutic polypeptide and block copolymer, where said block copolymer includes at least one water-soluble non-ionic segment and at least one poly-ionic segment, where said poly-ionic segment includes at least one charge, opposite to charge of therapeutic polypeptide, where said complex has morphology core-shell, where core contains therapeutic polypeptide and poly-ionic segment of block copolymer and where shell contains water-soluble non-ionic segment of block copolymer, and b) at least one pharmaceutically acceptable carrier.

EFFECT: group of inventions ensures increased efficiency of treatment of neurological diseases.

39 cl, 23 dwg, 14 tbl, 12 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions relates to peptides, isolated from human basic proline-rich lacrimal protein (BPLP), in particular to opiorphin, and is intended for application in manufacturing medication for treatment or prevention of such disease as obsessive-compulsive disorder, narcolepsy, hypersomnia, reduction of vigilance, deficit of attention in children, bipolar disease, dysthymic disorder and cyclothymic disorder.

EFFECT: application of group of inventions ensures application of peptides, which do not have at all or have very weak side effects.

15 cl, 3 dwg, 6 tbl, 7 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of general formula (1), in which Y1, Y1', Y2, Y2', Y3, Y3', Y4 and Y4' denote -H; R1 and R2 denote an unsubstituted -C1-8-aliphatic; R3 denotes an unsubstituted -C6-16-aryl; R4 denotes -H or -C(=O)R0, where R0 denotes -C1-8-aliphatic, unsubstituted or mono- or polysubstituted with substitutes independently selected from a group consisting of -F, -Cl, -Br, -I and -CN; Q denotes unsubstituted -C1-8-aliphatic-heteroaryl; X denotes =O, =CR6R7 or =N-R6, wherein R5 denotes -NH2, -NH-(unsubstituted-C1-8-aliphatic) or -N-(unsubstituted-C1-8-aliphatic)2, if X denotes =O, or R5 and R6 together form a 5-member ring in which the remaining ring atoms independently denote C, N, S or O, wherein the 5-member ring denotes 1,3,4-oxadiazolyl, 1,2,4-oxadiazolyl, oxazolyl or thiazolyl, in each case unsubstituted or monosubstituted with unsubstituted C1-C8aliphatic or =O, or unsubstituted tetrazolyl, if X denotes =N-R6, or R5 and R6 together form unsubstituted phenyl, and R7 denotes -H, if X denotes =CR6R7, where "aliphatic" in each case represents a branched or straight, saturated hydrocarbon residue; "aryl" in each case independently denotes a carboxylic ring system containing at least one aromatic ring which does not contain heteroatoms, where the aryl may be optionally condensed with other saturated, (partially) unsaturated or aromatic ring systems; "heteroaryl" denotes indolyl; in the form of a separate stereoisomer or a mixture thereof, in the form of free compounds and/or physiologically compatible salts thereof. The compound of formula

is used to obtain a medicinal agent having affinity for the µ-opioid receptor and the ORL1-receptor, and for treating pain.

EFFECT: substituted cyclohexyldiamines, having affinity for the µ-opioid receptor and the ORL1-receptor.

7 cl, 1 tbl, 29 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel compounds of general formula (1), which possess affinity for µ-opioid receptor and ORL1-receptor, to medications, containing said compounds, and to application of said compounds for obtaining medications, suitable for treating pain, fear, stress and other diseases or conditions. In general formula (1) Y1, Y1', Y2, Y2', Y3, Y3', Y4 and Y4' stand for -H; R1 and R2 independently on each other stand for -H or -CH3; on condition that R1 and R2 both simultaneously do not stand for -H; Q stands for: -C6-16-aryl, non-substituted or mono- or poly-substituted with -F, -Cl, -Br or -I; or heteroaryl; R3 stands for: -C1-8-alkyl, non-substituted or mono- or poly-substituted -OR0, where R0 stands for non-substituted -C1-3-alkyl; non-substituted -C3-6-cycloalkyl-C1-4-alkyl; non-substituted -C1-4-alkyl-C3-6-cycloalkyl; -C6-16-aryl, non-substituted or mono- or poly-substituted with -F, -Cl, -Br, -I, -CN, -R0 or -OR0, where R0 stands for non-substituted -C1-8-alkyl; or heteroaryl; n stands for 0; X stands for -NRA-; RA stands for -H or -R0; where R0 stands for non-substituted -C1-4-alkyl; and RB stands for -C(=O)R0; where R0 stands for non-substituted -C2-8-alkenyl-C6-16-aryl or non-substituted -C1-8-alkyl-(C6-16-aryl)1-2.

EFFECT: obtaining compounds for obtaining medications, suitable for treatment of pain, fear, stress and other diseases or conditions.

10 cl, 14 tbl, 164 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to methods of treating or relieving severity of disease in patient, where disease is selected from mucoviscidosis, hereditary emphysema, chronic obstructive pulmonary disease (COPD), "dry eye" disease. Methods include introduction of effective amount of N-(5-hydroxy-2,4-di-tert-butylphenyl)-4-oxo-1H-quinoline-3-carboxamide or pharmaceutical composition, containing said compound, to patient.

EFFECT: treatment of relief of disease severity in patient, where disease is selected from mucoviscidosis, hereditary emphysema, chronic obstructive pulmonary disease (COPD), "dry eye" disease.

16 cl, 15 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the chemical-pharmaceutical industry and represents an orally disintegrating tablet composition, which includes particles of a therapeutic preparation, containing: a therapeutically effective quantity of, at least, one therapeutic preparation; 0.5-3% ODT binding polymer; sugar alcohol and/or saccharide; and a disintegrant, with particles of the therapeutic preparation being prepared by granulation of, at least, one therapeutic preparation, sugar alcohol and/or saccharide and the disintegrant in the presence of the ODT binding polymer, where the composition mainly disintegrates within approximately 30 seconds after contact with saliva in the oral cavity or in testing by a disintegration test <USP 701>.

EFFECT: drug form can be applied in elderly patients and patients with swallowing disorders.

28 cl, 8 dwg, 13 tbl, 5 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel 3-phenyl-3-methoxypyrrolidine derivatives of formula , to any of its enantiomers or any mixture of its enatiomers, or its N-oxides, or its deuterated analogues, or its pharmaceutically acceptable salts, where R1 stands for F, Cl; R2 stands for F, Cl; R3 stands for H, CH3 or CH2CH3; on condition that the said compound does not represent 3-(2,4-difluorophenyl)-3-methoxypyrrolidine and 3-(3,5-difluorophenyl)-3-methoxypyrrolidine.

EFFECT: compounds are useful for a modulation of extracellular levels of dopamine and norepinephrine catecholamines in areas of the mammalian brain cortex, which makes it possible to use them for treatment of the nervous system disorders.

11 cl, 1 tbl, 51 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine and deals with an application of an antibody, which binds with residues of 1-5 or 3-7 A-beta, to reduce vascular amyloid in a patient with cerebral amyloid angiopathy, with the antibody being introduced intravenously or subcutaneously.

EFFECT: invention provides purification of the patient's vessels from amyloid deposits.

9 cl, 2 ex, 6 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to using 1-{4-[1-(4-cyclohexyl-3-trifluoromethylbenzyloxyimino)-ethyl]-2-ethylbenzyl}azetidine-3-carboxylic acid or its pharmacologically acceptable salt in treating demyelinated peripheral neuropathy specified in chronic inflammatory demyelinated polyradiculoneuropathy, multifocal motor neuropathy with conduction block or paraproteinemic demyelinated peripheral neuropathy.

EFFECT: using 1-{4-[1-(4-cyclohexyl-3-trifluoromethylbenzyloxyimino)-ethyl]-2-ethylbenzyl}azetidine-3-carboxylic acid for treating demyelinated peripheral neuropathy .

4 dwg, 2 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: halogenated hydrocarbonate chloride sodium, alkaline, boron, high-magnesium, iodine and fluorine natural mineral water 'Lazarevskaya Tselebnaya' No. 84-E of the Volkonskoye deposit in Sochi is taken according to the following procedure: 18-20 minutes before meals in small sips, 6 times a day daily in a dose of 180-200 ml at t=24-25°C for 40 days every 3-5 days with taking the above natural halogenated mineral water in the same amounts for the following 45 days. The therapeutic course makes 3 years and repeats every 3 months.

EFFECT: method enables reducing metabolic disorders by a systemic insulin-producing effect in a combination with a hypolipidemic and diuretic component.

3 cl, 4 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: according to one version, the method involves studying the heart rate variability and a motion state, dietary nutrition, baths with mineral water, mineral water intake, physiotherapeutic procedures. The dietary regimen is specified taking into account the measured immunoglobulin IgG values to detect food intolerance and elimination thereof from the nutrition. Low-salt sulphate calcium-magnesium-sodium mineral water is taken. The baths are taken with mineral water from a water-bearing formation of Middle Devonian at a depth of 1100-1278 m by using mineral water representing a salt brine of Devonian Sea M 240-260 g/dm3 of sodium-chloride composition Cl>95, Na++K+>80 mg-eq.%, with an acid reaction of the medium, at pH 4.7-5.5. According to the other version, the method additionally contains massage sessions and acupuncture taking into account the patient's heart rate variability.

EFFECT: group of inventions provides more effective health improvement by taking into account individual food intolerance and the patient's autonomic nervous system features.

2 cl, 3 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a method of obtaining mineral silicic water (MSW), intended for application for medical purposes. The method of obtaining includes hydrolysis of tetraethoxysilane in the TEOS mixture: ethanol: water, acidified by HCl. Nanosol is obtained at a temperature of 55-65°C for 1.5 hours with evaporation of ethanol to the volume reduction by 1/3, then, dilution of the obtained nanosol with a physiological solution NaCl is carried out in 2 steps with equal portions of the physiological solution, preliminarily heated to 40-50 in a ratio of volumes of the initial nanosol: physiological solution 1:7 with 15-minute interval. After each dilution a temperature of the solution is kept in the range of 55-65°C.

EFFECT: increase of the compound application efficiency.

1 ex

FIELD: medicine.

SUBSTANCE: halogen-containing hydrocarbonate chloride sodium, alkaline, boron high-magnesium, iodine and fluorine natural mineral water 'Lazarevskaya Tselebnaya' No. 84-E of the Volokonskoye deposite in Sochi is taken according to the following procedure: 30-35 minutes before meals in small sips, six times a day daily in a dose of 200-250 ml at t°=(23-24)°C, for 45 days every 2-3 days with taking the above natural halogen-containing mineral water in the same volumes for the following 45 days. The therapeutic course makes 3 years.

EFFECT: method enables improving the health status in the individuals subject to the hazardous effect of radionuclides taken with water or food.

2 cl, 6 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to a method of preventing complications of rhinitis or an influenza-like syndrome. The method of preventing complications of rhinitis or the influenza-like syndrome consists in the following: an isoosmotic ionic sea water-based solution with osmolarity, equal to 250-350 mOsm/kg, is introduced daily into each nostril of patients suffering from rhinitis or the influenza-like syndrome, and at the remission stage in the certain regimens.

EFFECT: increased method efficiency.

9 cl, 13 dwg, 13 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: method involves a dietary therapy, taking mineral water in an amount of 100-150 ml, 3 times a day and exposure to a physical factor. What is used is the Pevzner's diet No. 5. Karachinskaya chloride-hydrocarbonate sodium gas-free mineral water of total mineralisation up to 3 g/dm3, at a temperature of 38-40°C is taken 30-40 minutes before a meal. The physical factor represents a magnetic laser therapy and an EHF therapy. The contact magnetic laser therapy covers three zones sequentially at a frequency of 5 Hz: an epigastric zone and the right and left upper hypochondria along the midclavicular lines, for 4 minutes for each zone within the course of 10 procedures. The EHF therapy involves combined exposure on two projection zones: in the right hypochondrium and on the sternum generated by a broadband noise emitter at an emission frequency of 40-63 GHz, for 20 minutes, every day within the course of 10 procedures.

EFFECT: method provides more effective rehabilitation treatment following endoscopic cholecystectomy ensured by the early integrated therapeutic exposure.

2 ex, 4 tbl

FIELD: medicine.

SUBSTANCE: method involves the intake of low-mineralised low-carbonate sulphate-hydrocarbonate sodium-calcium mineral water of Slavyanovskiy source. The mineral water is taken 45 minutes before meals, in a dose of 3.3 g/kg of body weight per one intake, 3 times a day. That is combined with a partial-load physical activity, dietary therapy No. 5, mineral baths with the above mineral water at temperature 36-37°C, for 15 minutes, every second day; the therapeutic course involves 10 procedures; that is also combined with a dynamic electrical nerve stimulation (DENS) according to the schedule. The therapeutic exposure is segmental at frequency 7710 Hz for 10 minutes. The therapeutic exposure covers a projection of a liver at frequency 10 Hz for 5-10 minutes. The therapeutic exposure covers a projection of a pancreatic gland 77 Hz for 10 minutes and biologically active points (BAPs) GI-4(He Gu) and RP(sang-yin-jiao). The BAP exposure with programmed minimum effective dose (MED) is alternated every second day. The therapeutic course is 10 procedures.

EFFECT: method provides relieving pain and dyspeptic syndrome, improving the functional status of the pancreatic gland, regulating the digestion process and stimulating the adaptive reserves.

3 ex, 4 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely gynaecology, physiotherapy. A method involves the integrated treatment of the patients with genital endometriosis and hysteromyoma. The treatment involves taking mineral water, observing a biologically programmed light pattern, taking radon baths and radon gynaecological irrigations and small enemas, as well as conducting a laser therapy of biologically active points (BAPs). The patients take carbonated chloride-hydrocarbonate-sulphate sodium-calcium warm Narzan water taken from sources No. 4, No. 7 and No. 24, 3.4 mg per kg 3 times ad day, 40 minutes before meals. The radon baths are taken with the radon concentration of 1.5 kBq/l. The radon gynaecological irrigations and microenemas are performed with the radon concentration of 6.5 kBq/l, temperature 36°C, for 15 minutes within the course of 10-12 procedures. The BAP laser therapy is conducted in an autoresonant mode. The BAPs of anterior median meridian are covered, including: 1-2 (qu-gu), 1-3 (zhong-ji), 1-4 (guan-yuan), 1-5 (shi-men), 1-7 (yin-jiao); renal meridian: R-12 (da-ho), R-13 (qi-xu), R-14 (si-man), R-15 (zhong-zhu), R-16 (huang-shu); bladder meridian: V-31 (shang-liao), V-32 (ci-liao), V-33 (zhong-liao), V-34 (xia-liao); posterior median meridian: T-2 (yao-shu), T-3 (yao-yang-guan), T-4 (min-man), T-5 (xuan-shu). Using the radon baths of the different radon concentrations 'softens' an effect of the absorbed radiation dose on the homeostasis systems and preserves an effect of a high absorbed dose on the genital system. The laser therapy in the autoresonant mode within pathological BAPs improves the accuracy of the exposure on the pathological processes within a target organs.

EFFECT: method prolongs the remission, normalises the hormonal ratios in the remote period.

2 dwg, 4 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to physiotherapy, balneotherapy. Taking baths is realised. Bath includes gas-saturated water, and beer. Saturation with gas is performed by addition of fresh non-filtered beer in ratio 1:10 and supply of air, heated to 25°C from bottom to top. 1/2 part of water, heated to 40°C is poured into bathtub. After that, beer is added and then water, heated to 40°C, in amount of remaining 1/2 part. Bathtub is made from oak with holes.

EFFECT: method increases efficiency of bath realisation due to complex impact on organism with thermal and chemical factors and aeromassage.

FIELD: medicine.

SUBSTANCE: invention refers to medicine, and aims at treating irritable bowel syndrome with diarrhoea. What is used is a low-mineralised sodium hydrocarbonate Abalakhskaya mineral water (AMW) with an faintly alkaline reaction of aqueous medium. The complex therapeutic course makes 21 days including drinking therapy - 18 days, a single drinking dose of AMW of temperature 38-40°C is gradually increased from 50-80 ml to 180-200 ml; the procedures of duodenal drainage are performed with the use of AMW of temperature 37-38°C in the amount of 200 ml of a single dose; for the procedures of intestinal irrigations, AMW is pre-heated to 40-42°C, while a single dose makes 500 ml gradually increased to 800 ml; the procedures of intestinal irrigations are alternated with baths.

EFFECT: method provides higher clinical effectiveness in irritable bowel syndrome, normalised intestinal motility.

2 ex

FIELD: medicinal microbiology, medicine, pharmacy.

SUBSTANCE: invention relates to agents used for enhancing sensitivity of microorganisms to antibacterial preparations. Invention involves applying hydrocarbonate chloride-sodium drinking mineral water "Obukhovskaya" with the total mineralization 1.8-2.2 g/l as an agent for enhancing sensitivity of microorganisms to antibacterial preparations that is used early for treatment of atopic dermatitis and as an agent for treatment of iodine-deficient states. It has been found by method using disks that mineral water "Obukhovskaya" provides enhancing sensitivity of microorganisms to such antibacterial preparations as antibiotics and specific preparations against yeast-like fungi.

EFFECT: improved and valuable agent.

6 tbl, 6 ex

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