Tableted antimicrobial composition
SUBSTANCE: tableted antimicrobial composition contains polyhexamethylene guanidine hydrochloride (PHMH) in a combination with at least one ingredient specified in a group: quaternary ammonium compound (QAC), N,N-bis-(3-aminopropyl)dodecylamine and persol, as well as with an alkaline metal iodide and ammonium iodide. The antimicrobial composition has the following ratio of ingredients: PHMH - 10 to 70 wt %; QAC, N,N-bis(3-aminopropyl)dodecylamine and/or persol - 1 to 30 wt %; an alkaline metal iodide and ammonium iodide - 0.1 to 20 wt %.
EFFECT: using the invention provides the fast-acting tableted antimicrobial composition having a wide antimicrobial spectrum and a higher level of biocidal activity.
5 cl, 2 tbl, 2 ex
The technical FIELD TO WHICH the INVENTION RELATES.
The invention relates to the field of medicine, sanitation and hygiene, and in particular to means for disinfection of surfaces of medical devices and other items in medical institutions, in the infectious foci, sanitary transport, food industry, public catering enterprises, utilities and other
The LEVEL of TECHNOLOGY
Known tablets disinfectants "Absolute hydroxy" and "PFC-T active substance which is peroxyde of potassium fluoride (see http://www.infodez.ru/product/33_absolyutsid_oksi.html, . Tablets of Absoluted hydroxy contain 24÷34% peroksigidrat potassium fluoride and dissolved in water at room temperature for 20÷22 minutes. Tablets PFC-T" contain 28÷38% of peroksigidrat potassium fluoride and dissolved within 15 minutes.
It is also known tablets disinfectant "designback-super (http://desinbak.ru/index.php?doc&id=1,6,8). It contains a stabilized mixture of peroxide compounds (26÷32%, in terms of hydrogen peroxide). In addition, the product contains a stabilizer (0,1÷0,3% alkyldimethylbenzylammonium), pH Adjuster (0,4÷0,8% borax), washing additive and flavoring. The tool is dissolved in water at room temperature for 22±2 minutes.
Despite the convenient consumer who Orme, all these tools have a strong corrosive properties and lack of antimicrobial activity, particularly against viruses.
Known tablets disinfectant means "Velta", representing almost pure clathrate Quaternary ammonium compounds with urea (see instructions for use http://www.dezreestr.ru/instr/Veltab.html). In contrast to the above means, it is recommended not only for disinfection of various objects, but also for the sterilization of medical products. The tool is dissolved in water at room temperature for 20÷22 minutes.
The modes of application of the tool shown in the above instructions should be critically evaluated because it is well known that Quaternary ammonium compounds have high activity against gram-positive bacteria, is much less active against gram-negative bacteria, mycobacteria and fungi, even less active against viruses (particularly ineffective against polioviruses) and are not sporocidal, i.e. unsuitable as sterilants (http://cmr.asm.org/content/1211/147.full.pdf+html). In addition, a significant drawback of all funds on the basis of a single Quaternary ammonium compound is the rapid emergence of resistant to strains of pathogenic microorganisms.
izvestno tablets disinfectant, containing as active substance polyhexamethylene guanidine hydrochloride (phmg), characterized in that it additionally contains a mixture of alkaline and acidic components in the following ratio of components: pgmg from 1 to 99 wt.%, the mixture alkaline and acidic components from 99 to 1 wt.% (RF patent for the invention №2452513). The alkaline component are alkali metal salts of carbonic acid, and the acid component selected from citric, tartaric, fumaric maleic, adipic, malic, sulfamic, oxalic, and (or) of boric acid. The mixture alkaline and acidic components can accelerate the dissolving tablets, facilitates the efficient dispersion of particles pgmg and their soopermexican with water, provides a neutral level of pH of the resulting solution (6,5÷7,0) due to selection of the desired ratio of components. The likely implementation of this patent is the "Notabs"containing 52% phmg (http://www.dezreestr.ru/instr/Neotbs.html'). It is soluble in water at room temperature for 5÷6 minutes.
The lack of funds from the Russian patent for invention №2452513, you should consider the sensitivity to moisture of the air, as moisture initiates a chemical reaction between the alkaline and acidic components, resulting in the destruction of the tablets. When specified in the patent States that the use of PGMs ru is et to get the disinfectant with high activity against a broad spectrum of microorganisms, including their spore forms. This contradicts the common opinion that all known biocidal derivatives of guanidine low activity against mycobacteria, fungi, and especially viruses (some viruses such as the virus of foot and mouth disease - resistant pgmg) and do not have spores at room temperature (http://cmr.asm.Org/content/l12/1/147.full.pdf+html, http://www.infodez.ru/product/163_bior_1.html. http://www.infodez.ru/product/1311_polisept.html).
Although in example 4 of this patent States that when the concentration of PGMs in the working solution of 0.02% 100%destruction of tubercle bacilli occurs within 5 min, this information is questionable, as in other known disinfectants based on pgmg as the only active substance, such as Policept" and "BIOR-1", a similar result is achieved for 120 minutes at a concentration of PGMs 2%, or 30 minutes at a concentration of PGMs 5% (http://www.infodez.ru/product/1311_polisept.html, http://www.infodez.ru/product/l163_bior_1.html). Obviously, adding to pgmg such auxiliary components, as sodium bicarbonate and fumaric acid, cannot serve as a reason for such significant differences in tuberkulocide activity means to example 4 of the patent of the Russian Federation 2452513 and means "bear-1" and "Policept".
The modes of sterilization of medical devices described in the aforementioned application instructions "of Newtabs" vig is yadyat improbable: 60 min at a concentration of pgmg 0,04%, 30 min at a concentration of 0.05%, 15 min at a concentration of 0.1% and 5 min at a concentration of 0.2%, such as sporicidal activity does not possess even the drugs peracetic acid. Experimental verification showed that in fact "Notabs" does not provide for the sterilization of medical products.
DISCLOSURE of INVENTIONS
The objective of the invention is to provide a fast-acting antimicrobial compositions in the form of tablets, devoid of the above disadvantages of the known disinfectants and with a broad antimicrobial spectrum.
The problem is solved in that the inventive composition includes a synergistic complex of pgmg in combination with at least one component selected from the group of substances with antimicrobial activity:
- Quaternary ammonium compound (QAC),
and at least one mineral salt selected from the group:
iodide of an alkali metal,
iodide of ammonium,
in the following ratio of components:
- Pgmg from 1 to 70 wt.%;
HOURS, N,N-bis(3-aminopropyl)dodecylamine and/or Persol - from 1 to 30 wt.%;
iodide of an alkali metal and/or ammonium iodide is from 0.1 to 20 wt.%.
Non-limiting examples of the HOUR include, in particular, the pyridinium chloride, alkyldimethylbenzylammonium one chloride, alkyldimethyl(active compounds)ammonium chloride, didecylammonium chloride, didecylammonium bromide and pyridinium bromide. As percale can be used peroxyde urea and/or procovery mineral salts, such as perborate sodium, potassium persulfate, percarbonate sodium, peroxyde potassium fluoride or peroxyde of ammonium fluoride.
Source phmg is introduced into the formulation in the form of a fine powder of HOURS in individual form or in the form of clathrates with urea.
The compositions may also contain other ingredients, including detergent additives, stabilizers, corrosion inhibitors, complexing agents, pH regulators, dyes and flavoring.
In the patent literature describes a liquid antimicrobial composition comprising synergistic complexes pgmg+H (patent RU 2275193 C2), pgmg+N,N-bis-(3-aminopropyl)dodecylamine (patent RU 2172637 C1), pgmg+H+N,N-bis-(3-amino-propyl)dodecylamine (patent RU 2317950 C1) and pgmg+hydrogen peroxide (patent RU 2337714 S1). The iodides of alkali metals and ammonium iodide has not previously been used in the composition of disinfectants (the only exception is iodine tincture, which includes potassium iodide as a functional additive; see http://www.altermed.bv/index.php?item=prep&g=%D2&p=1521&ps=392877').
Not wishing to be limited to any particular theory is th, we assume that the addition of iodide turns pgmg and the aforementioned chloride and bromide Watch in appropriate iodine derivatives, molecules which have a greater positive charge of the cation, contributing to their adsorption on the negatively charged surface of microbial cells, and possess significantly greater lipophilicity, which facilitates their diffusion through the cell wall of microorganisms and enhances hydrophobic interactions with phospholipids and proteins of the cytoplasmic membrane. In addition, it is possible that oxidative enzymes of microorganisms transform ideny anion to molecular iodine (I2), which is a more powerful antiseptic than pgmg and Watch (http://wwwn.cdc.gov/publiccomrnents/comments/guidelines-for-the-prevention-of-intravascular-catheter-related-infections/2021.ashx).
The claimed composition was prepared by thorough mixing of all components, followed by pelletizing the mixture. The tablets are completely dissolved in water at room temperature for 12÷15 minutes.
The advantages of the proposed composition become apparent from the examples below.
The IMPLEMENTATION of the INVENTION
The following examples are given only to illustrate the inventive idea. Nothing in this section the description should not be construed as limiting the scope of the claims. It should be clear that the average person, the sign of the nd with the ideas of the present invention, can use its main features and to make equivalent replacements to achieve the target and without deviating from the spirit and scope of the present invention.
The tests were carried out by the method described in "Methods of testing disinfectants to assess their safety and effectiveness", M, 1998, am 2, near-real conditions of use of funds. As models were selected as the most resistant to cationic disinfectants types of microorganisms Mycobacterium tuberculosis and polio virus.
Used a tablet composition containing 40% pgmg, 40% of clathrate didecylammonium chloride, 8% N,N-bis(3-aminopropyl)dodecylamine, 5% ammonium iodide, 2% of the trylon B and 5% detergent additives. On cleansed and sterilized medical instruments caused a cell culture of Mycobacterium tuberculosis, and then process them by wiping with a solution containing 2 tablets of the claimed composition by mass of 1 g in 10 l of water. After 5 minutes registered 100%cell death B5.
Table 1 provides comparative data on tuberkulocide activity of this composition in comparison with the "Westbam" and "Neoteam".
|The concentration of working solution that provides 100%cell death within 5 minutes, g/l (in preparation)|
|The composition according to example 1||0,2|
On cleansed and sterilized medical instruments struck a culture of polio virus, and then process them by wiping with a solution containing 2 tablets of the claimed composition by mass of 1 g in 10 l of water. Each tablet contained 45% pgmg, 12% of pyridinium chloride, 20% percarbonate sodium, 15% potassium iodide, 1% of the trylon B, 5% corrosion inhibitors and 2% detergent additives. After 10 minutes registered 100%destruction of the virus.
Table 2 shows comparative data for virucidal activity of this composition in comparison with the "Westbam" and "Neoteam".
|The name means||The concentration of working solution that provides 100%destruction of the virus in 10 minutes g/l (in preparation)|
|The composition according to example 2 izobreteny the||0,2|
Tableted compositions of examples 1 and 2 do not disintegrate with prolonged stay in the open air, at least for 3 months and do not have strong corrosive properties.
Thus, the technical result of the invention is to provide a fast-acting antimicrobial compositions in the form of tablets, with a broad antimicrobial spectrum and a higher level of biocidal activity than the known tablets disinfectant.
1. Antimicrobial agent in the form of tablets containing polyhexamethylene guanidine hydrochloride (phmg)at least one antimicrobial substance is selected from the group consisting of Quaternary ammonium compounds (QAC), N,N-bis-(3-aminopropyl)dodecylamine and Persol, at least one iodide selected from the group consisting of alkali metal iodide and ammonium iodide, in the following ratio of components (wt.%): Pgmg - 1,0÷70, an antimicrobial substance - 1,0÷30, iodide - 0,1÷20.
2. The tool according to claim 1, in which the HOURS selected from the group consisting of pyridinium chloride, alkyldimethylbenzylammonium chloride, alkyldimethyl(active compounds)ammonium chlorine is IDA, didecylammonium chloride, didecylammonium bromide and pyridinium bromide.
3. A tool according to any one of claims 1 or 2, in which Persol selected from the group consisting of procalert urea, sodium perborate, potassium persulfate, percarbonate sodium, procalert fluoride of potassium and procalert of ammonium fluoride.
4. A tool according to any one of claims 1 or 2, additionally comprising at least one substance selected from the group consisting of detergent additives, stabilizers, corrosion inhibitors, complexing agents, pH regulators, dyes and fragrances.
5. The tool according to claim 3, additionally comprising at least one substance selected from the group consisting of detergent additives, stabilizers, corrosion inhibitors, complexing agents, pH regulators, dyes and fragrances.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to disinfection, and can be used for disinfection of livestock buildings, vehicles, various equipment and equipment. The disinfectant represents a micronised powder of a particle size up to 20 mcm, containing phosphogypsum (CaSO4*2H2O) - 25-70%, calcium carbonate (CaCO3) - 15-30%, kaolin (Al2Si2O7*2H2O) - 10-40%, zinc sulphate (ZnSO4*7H2O) - 0.1-1%, copper sulphate (CuSO4*5H2O) - 0.1-1%, ferric sulphate (FeSO4*7H2O) - 0.2-2%, chloramine (C6H5SO2N(Na)Cl*3H2O) - 0.1-0.5% and natural essential oils - 0.1-0.5%.
EFFECT: invention enhances the bactericidal activity of the disinfectant on gram-positive and gram-negative microorganisms with reducing the concentrations of the active substances and increasing the storage period of the ready product.
SUBSTANCE: group of inventions relates to water treatment. The water treatment composition contains an active component and a base, where the active component is a liquid organic compound in form of oil, and the base is a ceramic or solid organic compound selected from a group comprising wax, fat, plastic, lubricant substances and mixtures thereof. Said active component is essentially insoluble in water. The group of inventions also relates to a water treatment method, involving addition of said water treatment composition to water.
EFFECT: group of inventions provides water treatment and enables to maintain water purity for a long period of time.
11 cl, 20 tbl, 14 ex
SUBSTANCE: algicide has the following composition, wt %: partial manganese-zinc salt of polyacrylic acid 1.88-2.5; sodium salicylate 37.88-38.25; sodium citrate 22.73-23.12; quaternary ammonium salt having the composition: [(C10H21-C18H37)(CH3)2(CH2C6H5(N]+Cl- 35.25-36.50; water - the rest. Process solution are used in concentration of 0.01-0.25 wt %.
EFFECT: algicide has high solubility in water and is more effective compared to existing compositions on its effect on microalgae.
1 tbl, 6 ex
SUBSTANCE: invention refers to the area of medicine. It describes the support with electrob donor surface, on the surface of which there are metallic particles containing palladium and at least one metal chosen out of group consisting of gold, ruthenium, rhodium, osmium, iridium and platinum, and amount of said metallic particles is approximately from 0.001 to 8 mcg/cm2. The examples of devices with such coating include contact lenses, cardiac stimulators, electrodes for cardiac stimulators, stents, dental implants, hernial nets and meshworks, equipment for blood centrifugation, surgical instruments etc.
EFFECT: surface properties modification of the support influencing its biocompatibility and antimicrobial properties.
18 cl, 4 tbl, 17 ex
SUBSTANCE: inventions can be used to disinfect and decontaminate drinking water in extreme conditions, in field conditions or when consuming water from surface sources in population centres without centralised water treatment and supply systems. The solid composition contains a chlorine-containing disinfectant - sodium or potassium salt of dichloroisocyanuric acid (5-25 pts.wt), alkali metal chloride (10-75 pts.wt), additives which intensify disinfectant action - alkali metal salt of acetic or phosphoric acid or trichloroisocyanuric acid (1-30 pts.wt), as well as dechlorinating additives (4.5-50 pts.wt), where the dechlorinating additives used are cysteine and/or ascorbic acid, alkali or alkali-earth metal salts thereof, as well as mixtures thereof. The composition can be prepared in form of a single unit package or in form of a two-component unit package. The composition additionally contains binding substances, dispersants, dye and a fragrance component.
EFFECT: composition is cheap, nontoxic and provides high biocidal effectiveness, cuts decontamination time compared to other existing agents, provides fast and quantitative neutralisation of active chlorine, which, as a result of treatment, enables to obtain decontaminated, high-quality drinking water.
13 cl, 10 ex
SUBSTANCE: invention refers to technology of disinfectant polymer materials and can be used in chemical industry as a filter medium or an additive for mixed filter mediums or a component of filter composites for disinfecting and treating of fluids, mainly potable water, or gases. The material consists of a solid, water insoluble, polymer material containing chlorine atoms reversible connected with nitrogen and phosphorus atoms of oxidation degree +5, and cross-linked by linking phosphor-containing ions with melamine links of polymer chains. The method for making the material implies chlorination of the solid water insoluble cross-linked polymer material prepared by condensation of phosphate melamine and paraform or water soluble inorganic phosphate, melamine and paraform. Cross-linking of said material is ensured by linking phosphor-containing ions with melamine links of polymer chains directly during production of said product.
EFFECT: material is autooxidation resistanct, recovers active chlorine in controlled concentration and inactivates microorganisms in direct contact in liquid and gaseous mediums.
16 cl, 8 tbl, 13 ex
SUBSTANCE: invention concerns an oligodynamic composite material representing a layer of polymer material with electret properties wherein there is one first discrete element coming on one working surface of the electret material and made of metal particles of various electronic work function and able to show oligodynamic action. The composite material can also contain the other discrete elements representing a drug dispenser or absorption aids.
EFFECT: composite material distinguishes itself with high efficiency ensured by synergy effect of the electret material and the metal showing oligodynamic action.
17 cl, 4 dwg, 1 tbl, 18 ex
SUBSTANCE: invention concerns disinfectants on the basis of hydrogen peroxide, intended for disinfection of bacteriemically infected surfaces, potable water, systems of drinking and technical water supply, water in swimming pools, sewage. The concentrate contains, wt %: hydrogen peroxide 35-59 (in recalculation on 100% peroxide), soluble salt of silver 5-10-6-1.5 (in recalculation on metal silver), acidity regulator - to pH not higher than 4, complexing agent - to an equimolar parity with silver cations, dimethylsulfoxide (DMSX) - 0.1-5, water - the rest. At use on a place of work, a concentrate is diluted with water to demanded working concentration.
EFFECT: reception of disinfectant solutions which, at simplification and reduction of the "know-how" of a concentrate in price, possess high stability and penetrating ability, and also the raised bactericidal activity, especially in the presence of organic pollution.
5 ex, 1 tbl
SUBSTANCE: disinfecting tablets for water processing include homogenous mixture from not less than 75% by weight of hydrogenated calcium hypochlorite and not less than 25% by weight of heptahydrate of magnesium sulfate, and mixture contains water in amount not less over than 17% of all mixture weight; and average rate of tablet dissolution is less than 150 grammes a day. Also described is disinfecting tablet for water processing, including homogeneous mixture from not less than 75% by weight of hydrogenated calcium hypochlorite and not less than 25% by weight of heptahydrate of magnesium sulfate, and mixture contains water not less than 17% of total mixture weight and contains lime from 0.1% to 10% of total weight of hydrogenated calcium hypochlorite and of heptahydrate of magnesium sulfate.
EFFECT: tablets according to invention are rather slow-dissolving and have higher safety.
10 cl, 7 tbl
FIELD: water treatment.
SUBSTANCE: invention, in particular, relates to disinfection of drinking water under extremal conditions, under field conditions, or when consuming water from surface sources in residential sites having no centralized water-treating and water-supply systems. Solid composition comprises chlorine-containing disinfectant: dichloroisocyanuric acid sodium or potassium salt (2-25%), sodium or potassium chloride (10-75%) and additionally acetic or phosphoric acid alkali metal salt or trichloroisocyanuric acid (1-30%). Proposed composition can be used in the form of dispensable dozed packaging as powder, granules, capsules, or tablets. Composition is further supplemented with binding agents, dispersants, colorant, odorant, whereas activated carbon is added to neutralize excess active chlorine formed. Composition of invention is inexpensive and nontoxic preparation, easy to use, and providing higher biocide efficiency, shortened disinfecting time, and lower concentration as compared to known compositions based on hypochlorites and dichloroisocyanurates.
EFFECT: increased water disinfection efficiency and reduced cost.
12 cl, 1 tbl, 7 ex
SUBSTANCE: invention relates to the field of poultry industry and is intended for sanation of poultry hatching eggs. The method comprises processing the egg surface with aqueous solution of preparation based on milk whey with lactulose and quaternary ammonium compound trimethyloctadecyl ammonium bromide. As the aqueous solution of the preparation based on milk whey with lactulose and quaternary ammonium compound trimethyloctadecyl ammonium bromide 0.1-0.2% aqueous solution of the preparation is used, taken in equal proportions and diluted with water in a ratio of 1:10. Hatching eggs are processed 2-4 hours prior to their laying for incubation.
EFFECT: use of claimed method enables to carry out effectively sanation of poultry hatching eggs.
1 tbl, 1 ex
SUBSTANCE: agent comprising ethanol, glycerol, Carbopol ultrese and softened water according to the invention comprises aminomethylpropanol, essential oil selected from the group: eucalyptus essential oil, lemon essential oil, peppermint essential oil, anise essential oil, jasmine essential oil with the following ratio of components in g per 100 g of gel: ethanol 65.0-66.0; glycerol 1.0-2.0; Carbopol ultrese 0.16-0.18; aminomethylpropanol 0.06-0.08; essential oil 0.005-0.03; softened water - up to 100.0.
EFFECT: invention has a high antimicrobial activity against pathogenic bacteria, fungi and viruses and provides safety for life and health of people without causing allergy.
4 cl, 4 ex
SUBSTANCE: biocidal composition for soaking napkins contains benzethonium chloride, sodium hydroxymethylglycinate, glycerine, decyl polyglucose, niacinamide, liposentol hydro, phenylmethanol and distilled water. Components are used in a defined ratio given in wt %.
EFFECT: invention improves biocidal properties of the napkin soaking composition.
3 tbl, 1 ex
SUBSTANCE: invention discloses a disinfectant and can be used in prevention and treatment facilities, at first aid facilities, disinfection facilities, child care centres, public catering facilities, public utilities, transportation, veterinary, agriculture, food industry enterprises and other sectors, as well as for pre-sterilisation cleaning of medical items, including surgical and dental instruments, rigid and flexible endoscopes and other instruments. The disinfectant contains catamine AB, isobornyl acetate, isopropanol, α-pinene, glutaric aldehyde, glycerine, a nonionic surfactant and water in defined ratios.
EFFECT: disinfectant does not cause corrosion in articles made of metal and decomposition of metals and endoscope units; does not cause organic contamination.
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to medicine, namely to clinical allergology, and may be used for extracorporeal allergen denaturation. That is ensured by treating a surface of objects with an allergen-denaturing composition. The composition contains calcium chloride or calcium acetate and lanthanum chloride or lanthanum nitrate in certain proportions.
EFFECT: combinations of the above metal salts selected in certain proportions provide the effective allergen denaturation ex vivo by a synergistic denaturation action of the given ingredients.
9 cl, 4 tbl
SUBSTANCE: synergistic antimicrobial composition contains a zinc salt of glyphosate and thiabendazole, wherein the weight ratio of thiabendazole to the zinc salt of glyphosate is from 0.1:1 to 10:1. A method of inhibiting the growth or controlling the growth of microorganisms in a construction material involves the step of adding the synergistic antimicrobial composition. A coating composition comprises the given synergistic antimicrobial composition. A dry film is made by a process comprising applying a layer of the synergistic composition to a substrate and drying.
EFFECT: controlling the growth of microorganisms, fungi, algae on the finish surfaces of the construction materials.
SUBSTANCE: described is a method of producing a highly purified disinfectant which contains polyhexamethylene guanidine hydrochloride, characterised by that flush water from production of polyhexamethylene guanidine hydrochloride in solid form is used. The flush water is mixed with 25% NaCl solution in ratio of 1:1 (polyhexamethylene guanidine hydrochloride solution with impurities: NaCl solution) while stirring constantly for 1 hour at temperature in the range of 50-60°C. Stirring is stopped and the mixture is cooled to 5°C, thereby dividing the mixture into two parts; the bottom part is drained, neutralised and sent for recycling and the top part containing up to 60-70% polyhexamethylene guanidine hydrochloride is further diluted to 50% with an aqueous solution of quaternary ammonium salts (QAS) to QAS concentration of not higher than 5%.
EFFECT: extracting highly purified, concentrated high-molecular weight polyhexamethylene guanidine hydrochloride from flush water, reducing the amount and toxicity of waste water, improving disinfecting properties and increasing output of the commercial-grade product when producing polyhexamethylene guanidine hydrochloride in solid form, reducing cost.
1 cl, 1 ex, 2 tbl
SUBSTANCE: invention refers to disinfection. The experimental method for the elimination of pathogenic and opportunistic microorganisms is characterized by the fact that a mixture containing the pathogenic and opportunistic microorganisms are processed with a disinfection composition which is metal oxyhydrate gel prepared by alkaline metal chloride deposition by 2% ammonia in a min. 5-litre reactor; fresh metal oxyhydrate 20-10-6 m3 is placed in an electrochemical cells with graphite electrodes of a charged cluster metal particle generator; what is added is a bacterial solution of the medium of 105 microbial cells in 1 ml dissolved in distilled water 10 ml; the medium is exposed to polarized currents of the cluster oxyhydrate particles of metal oxyhydrate gel for 2 to 6 hours; metal oxyhydrate gels are prepared by using metal chloride salts presented by zirconium or iron chloride salts with the electrode distance no more than 70 mm.
EFFECT: invention provides the more effective inactivation of pathogenic and opportunistic microorganisms that are infectious agents in human and animals.
7 tbl, 2 dwg, 6 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions discloses an antiviral agent (versions) able to inactive a virus. The antiviral agent characterised by containing the basic substance, cuprous microparticles, and inorganic microparticles to fix the cuprous microparticles on the basic substance. The inorganic microparticles are coupled together by chemical bonds formed between silane monomers found on the surface, and each of the inorganic microparticles is coupled with the basic substance by a chemical bond between silane monomer and the basic substance for the purpose of forming the areas wherein the above cuprous microparticles are expected to be accumulated.
EFFECT: group of inventions provides high antiviral activity.
16 cl, 3 tbl, 7 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to chemical-pharmaceutical and cosmetic industry and represents a hygienic handwash, preferentially before using contact lenses. The hygienic handwash contains ethanol, glycerol, 1,2-propylene glycol, Pherol A, Aloe Vera extract, a flavour and water; as an antibacterial additive, the product contains polyhexamethylene biguanidine hydrochloride, while a moisturising supplement - KM-25 (water/propylene glycol extract of glucomannan) in the following proportions, wt %: Rectified ethanol 56.0-65.0; Glycerol 0.6-2.0; 1,2-propylene glycol 0.7-1.2; KM-25 (water/propylene glycol extract of glucomannan) 0.009-0.012: Pherol A 0.009-0.015; Aloe Vera extract 0.008-0.02; Flvour 0.05-0.07; Polyhexamethylene biguanidine hydrochloride 0.1-0.5; Water - up to 100%.
EFFECT: invention provides developing a product for effective hand protection and cleansing.
2 cl, 1 tbl
SUBSTANCE: invention relates to agriculture. Concentrated liquid mineral composition, containing the following components is applied for spraying leaves: total ammonia nitrogen (%) 0.08-2%, potassium, expressed as K2O (%) 3-6%, magnesium, expressed as MgO (%) 0.4-0.8%, sodium, expressed as Na2O (%) 1-2%, calcium, expressed as CaO (%) 0-0.5%, total phosphates, expressed as SO3 (%) 3-6%, total phosphorus, expressed as P2O5 (%) 0%, chlorides Cl (%) 1-2%, bicarbonates (in % HCO3) 1.2-3.0%, boron (%) 0.1-0.2%, copper (%) 0.018-0.03%, manganese (%) 0.00005-0.006%, iodine (%) 0.02-0.04%, zinc (%) 0.00005-0.006%, iron 0.0002-0.003, water to 100%. Percent content is expressed in weight percent relative to the total composition weight.
EFFECT: invention makes it possible to improve adaptive response of plants to change of the environmental conditions.
9 cl, 5 dwg, 1 tbl, 6 ex