Method of treating endogenous intoxication syndrome caused by hyperproteolysis
SUBSTANCE: antiproteolytic preparation Ambene in a dose of 50-250 mg is introduced intravenously by the stream infusion for at least three days every 3-4 hours in a combination with heparin. Heparin is introduced subcutaneously is a dose of 250 units 4 times a day.
EFFECT: effective treatment of endogenous intoxication syndrome caused by proteolysis by blocking fibrinolysis and enhancing the detoxifying and anti-inflammatory action of Ambene.
2 tbl, 2 ex
The invention relates to medicine, in particular to toxicology, and can be used for the treatment of syndrome of endogenous intoxication caused by hyperpreterism in the case of acute poisoning caused by neurotropic substances steps.
Known in vitro methods (hemosorption, limfosorbtsiya, hemofiltration, plasmapheresis) edema of endogenous intoxication in acute poisoning with sorbents (Lopatkin N.A., Lopukhin, Y.M. Efferent methods in medicine : theoretical and clinical aspects of in vitro treatment methods). - M.: Medicine, 1989. - 352). Their disadvantages are the possible adsorption of oxygen getting into the blood particles sorbents, activation of blood coagulation and fibrinolysis.
The physico-chemical ways to treat endogenous intoxication applied transcranial electrical stimulation (mesodiencephalic modulation), ultraviolet blood irradiation (Luzhniki E.A., Goldfarb US Physiogeography acute poisoning. - M.: Malpractice-M, 2002. 200 C.).
Their disadvantages are the complexity, low efficiency, the need for additional equipment.
As pharmacological methods of treatment of endogenous intoxication apply sodium hypochlorite, antioxidants (tocopherol), Immunostimulants (T-activin). To fault the m treatment with sodium hypochlorite include its ability, as a strong oxidant injury of blood corpuscles, the disadvantages of tocopherol, T-activin - a low efficiency.
Closest to the claimed is a method of treatment of endogenous intoxication caused by hyperpreterism, by applying a natural inhibitor of fibrinolysis kontrikala (Aprotinin), (Sitkovskiy NB, Hanes G.S., Kutsenko T.A. proteolysis Inhibitors in pediatric surgery. - Kiev: Health, 1977. - 87 S.).
The disadvantage of this method, selected as a prototype, is alien to the body kontrikala as antigen, the ability to cause allergic reactions need to use large doses and prolonged administration to obtain the desired clinical effect.
Other prototype disadvantages are its high cost, complexity of industrial production and purification of the drug.
The present invention is to increase the effectiveness of treatment of endogenous intoxication caused by hyperpreterism, and cheaper treatment method.
According to the invention, the problem is solved in that in the method of treating syndrome of endogenous intoxication caused by hyperpreterism, including standard detoxification therapy antiproteolytic drugs, as antiproteolytic drug use is comfort ambien, which is injected intravenous bolus at a dose of from 50 to 250 mg for at least three days with an interval of 3-4 hours in combination with subcutaneous injection of heparin.
Ambien inhibits proteolytic process by blocking plasminogen activators and inhibiting the action of plasmin. It inhibits fibrinolysis, competitive saturating lessinvasive receptors, through which the plasminogen (plasmin) is associated with fibrinogen (fibrin), which leads to more effective treatment of endotoxemia, and also inhibits the formation of biogenic peptide complexes that can influence the exudative phase of inflammation. Ambien improves blood rheology, has a beneficial effect on circulation in the damaged tissues, preventing the development of hypoxia.
Amben is a domestic product, it is easy to obtain. Compared to the equally effective doses kontrikala, ambien 100 times cheaper. The economic effect of the application of ambana obvious.
This action ambien has a dose of from 50 to 250 mg. Doses less than 50 mg does not cause the desired effect, whereas the introduction in doses exceeding 250 mg can cause side effects.
The combined introduction of heparin enhances the detoxifying and anti-inflammatory effect of Albena. Heparin as an activator of anti-thrombin III, blocks the action of thrombin, etc the other vitamin K-dependent proteases of the coagulation cascade, reduces platelet aggregation. Anti-inflammatory effect of heparin is associated with improvement of microcirculation in inflammation due to suppression of intravascular thrombosis, inhibition of chemotaxis of neutrophils, reduce their adhesion to the endothelium and other
The claimed frequency regime and the introduction of Albena and heparin due to their pharmacokinetic characteristics. Therapeutic concentration amben is created in the blood when a single-step introduction. When administered intravenously, the maximum concentration of drug in the blood is determined immediately after administration and lasts up to 3 hours followed by a decline to 4 th hour. Therefore, the time interval between the introduction of this drug should not exceed 4 hours.
The duration of drug injection (not less than three days) is related to the fact that in the early toxicogenic phase (first, second, third days after acute poisoning, when the venom is in the bloodstream) contents of oligopeptides as markers, reflecting the level of endogenous intoxication, reaches its maximum (especially in the first day). Ambien promotes the redistribution of markers of endotoxemia in the direction of reducing their content in erythrocyte membranes, accumulation in the plasma and their subsequent excretion in the urine.
The concentration of oligopeptides in the blood correlates with the degree is to prolong activation of fibrinolysis. The introduction of inhibitors of proteolysis, in particular amben, reduces severity of endogenous intoxication.
According to scientific-technical and patent literature, the use of amben in combination with heparin for the treatment of endogenous intoxication in acute poisoning in medicine is unknown. Therefore, the claimed invention meets the criterion of "significant differences".
The method is as follows. The patient with acute poisoning neurotropic substance intravenous bolus injected ambien in a dose of from 50 to 250 mg every 3-4 hours for at least 3 days in combination with subcutaneous injection of heparin.
Patient M., 38 years old was admitted to the Department for the treatment of acute poisoning with a diagnosis of acute poisoning substance neurotropic action (azaleptin) severe. Diagnosis of chemical-Toxicological investigation of biological media. The exposure time is longer than 6 hours. When entering a serious condition, consciousness at the level of coma I-II century Skin pale, mydriasis, respiratory rate of 25 per minute, heart rate of 115 beats per minute, blood pressure of 90 mm and 60 mm Hg heart sounds deaf. Abdomen palpation soft.
The patient was obtained by infusion of glucose, saline, poliglyukina, lasiks, prednisolone, dopamine. Conducted hemosorption. In the future priest who drank to intravenous introduction of Albena in the form of a 1% solution of 15 ml (150 mg) every 4 hours. In combination with ambeno was subcutaneously injected heparin 2500 UNITS 4 times a day. Assessed the level of consciousness on a scale Glasgow, hemodynamics, additional indicators of the level of oligopeptides in plasma and erythrocytes at admission of the patient, on the 1st, 3rd and 5th day. On the 1st day was marked improvement in the level of consciousness to spoor - somnolence (9-11 points on the scale of Glasgow). By the end of the first day there was a decrease in the concentration of oligopeptides on erythrocytes in 2 times to 0.31 g/l (0.74 g/l at admission), but simultaneously increased their content in plasma and urine compared with baseline at the time of hospitalization. This coincided with the beginning of stabilization of the main clinical indicators - consciousness and hemodynamics. Discharged after cupping intoxication on the 5th day after the poisoning.
Patient K., 46 years old, was admitted to the Department for the treatment of acute poisoning with a diagnosis of acute poisoning substance neurotropic action (phenazepam) severe. Diagnosis of chemical-Toxicological investigation of biological media. The exposure time of more than 12 hours. When entering a serious condition, consciousness level spoor coma I tbsp. Skin pale, dry, respiratory rate 16 per minute, pulse 96 beats per minute, blood pressure of 110 mm and 60 mm Hg heart sounds deaf. Conducted cured the e: glucose, poliglyukina, lasiks, prednisolone, dopamine, amben. Ambien was injected intravenously 10 ml 1% solution (100 mg) every 4 hours, heparin 2500 UNITS subcutaneously 4 times a day. On the first day was marked improvement in the level of consciousness to somnolencia (11-12 points on the scale of Glasgow), to the end of the first day was observed at 1.5 times the decrease in the concentration of oligopeptides on the erythrocytes to 0.33 g/l (0.54 g/l at admission). Discharged after cupping intoxication on the day 3 after poisoning.
Lower content of oligopeptides in the plasma of patients treated with ambeno, remained until 5 days of observation. Especially pronounced difference is observed for the 3-day hospital stay.
Presented in the tables, the results of clinical studies conducted in experimental (20 patients) and control group (10 patients), show a positive effect of the proposed method.
|The influence of Albena on the dynamics of the clinical course of intoxication|
|Index||The time from receipt of the patient in the office|
|1 h||1 day||3 day||5 day|
|Control, n=10||The monitoring group, amben n=20||Control, n=10||The monitoring group, amben n=20||Control, n=10||The monitoring group, amben n=20||Control, n=10||The monitoring group, amben n=20|
|Recovery of consciousness (number of patients)||0||0||3||11||8||18||9||19|
|Stabilization of hemodynamics (number of patients)||0||0||14||9||9||19||9||19|
|Dynamics of the content of oligopeptides (g/l) in RosNOU blood (M±n) in patients with acute severe poisoning|
|The study period||The concentration of oligopeptides, g/l|
|Control (n=10)||Amben (n=50)|
|3 day||determined as 0.720±to 0.108||0,37±0,03*|
|5 day||in 0.288±0,021||0,270±0,016|
|Note the: * - the difference with the control was statistically significant (p<0,05).|
The proposed treatment method carried out in 50 patients with acute poisoning.
The inventive method improves the clinical course of acute poisoning, reduces or eliminates the expression of endogenous intoxication, which allows survival of the patients in serious condition, shortens hospital stay.
Ambien as a product of domestic production is easy to obtain and manufacture. Compared to the equally effective doses of a natural inhibitor of fibrinolysis kontrikala amben 100 times cheaper, than its obvious economic benefits.
A method of treating syndrome of endogenous intoxication caused by hyperpreterism, including standard detoxification therapy antiproteolytic preparations, characterized in that as antiproteolytic of the drug to enter amben dose of 50-250 mg intravenous bolus over at least three days with an interval of 3-4 hours and additionally introducing heparin subcutaneously at a dose of 250 IU 4 times a day.
SUBSTANCE: what is described is a biodegradable haemostatic therapeutic agent for control of bleeding, which provides co-immobilising ε-aminocapronic acid 50 mg, lysozyme 5 mg in distilled water 6.5 l for 3 hours at room temperature for dialdehyde cellulose 1 g at a degree of oxidation 12%. The material is pressed out and dried to residual moisture no more than 10% in the air in darkness. After having dried, the material is milled in a fine mill to particles having a size of 20 to 50 mcm. A rate of control of bleeding is 102 seconds. A time of total resorption is 10 days.
EFFECT: agent provides a high degree of hydrolytic destruction and a good haemostatic activity.
4 cl, 2 ex
SUBSTANCE: invention represents a biodegradable haemostatic therapeutic agent for bleeding. Using the prepared haemostatic agent according to the declared method provides a rate of control of bleeding making 45±2 seconds.
EFFECT: higher rate of control of bleeding.
4 cl, 2 tbl
SUBSTANCE: agent further contains aluminium and/or magnesium oxides and satisfies the formula: CaO·(SiO2)m·(M)n·(H2O)k, where M is Al2O3 and/or MgO; m=0.5-3.0; n=0.01-0.05; k=0.2-1.2.
EFFECT: shorter time for onset of hemostasis and low exothermic effect during interaction with blood.
2 tbl, 9 ex
SUBSTANCE: invention refers to medicine, namely to hematology and oncology, and concerns correction of amegakaryocytic thrombocytopenia. That is ensured by introducing a platelet concentrate and performing autologous peripheral haemopoietic stem cell transplantation with performing a single subcutaneous injection of romiplostim 200-300 mcg on the day of the transplantation.
EFFECT: method provides reducing a risk of the haemorrhagic complications following the high-dose chemotherapy, ensured by the fast and effective platelet growth.
2 ex, 1 tbl
SUBSTANCE: agent contains chitosan salt 75-95 wt % of polydisperse powders of chitosan hydrochloride, hydrobromide, formate, acetate, succinate, citrate, glycolate or lactate and polyhexamethylene guanidine hydrochloride 4-20 wt %. The chitosan salt and polyhexamethylene guanidine hydrochloride are covalently cross-linked by a polyfunctional compound 1-5 wt % of glycidyl ethers. The chitosan salt is specified with an average particle size of 0.2÷2.0 mm, degree of chitosan deacetylation 0.75÷0.95, and molecular weight 10÷500 kDa. The above polyfunctional compound of glycidyl ethers is presented by a diglycidyl ether of butandiol, di- or triethylene glycol or propylene glycol, oligoethylene oxide, as well as triglycidyl ethers of glycerol or trimethylol propane.
EFFECT: method possesses high blood sorption capacity, rapid hemostasis time and high antimicrobial activity.
3 cl, 2 tbl, 12 ex
SUBSTANCE: invention represents a hemostatic preparation containing a complex of aminocaproic acid and ferric iron stabilised with sodium chloride in the isotonic concentration. The invention aims at wound healing, small hemostasis at administering the first medical aid at the pre-hospital emergency evacuation.
EFFECT: what is provided is preparing the preparation very soluble in water and possessing high hemostatic activity, low costs and extended storage period.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to an antiseptic drug with haemostatic action for wound cleaning. The drug contains ingredients in the following ratio, wt %: an antimicrobial substance - 0.01-3, an active complex - 1-25, glycerol - 2-35 and water - up to 100. The antimicrobial substance is specified in a group consisting of cetyl pyridinium or cetyl methyl ammonium halogenide, chlorhexidine, miramistin and other quaternary bases applicable in medical practice to treat burns and to clean open wounds, and the active complex is presented by a haemostatic preparation in the form of a mixed-ligand chelated complex of zinc, ethylene diamine tetraacetic acid and ε - aminocapronic acid. The invention also refers to a method for preparing the antiseptic drug with haemostatic action. The method consists in the fact the active complex is prepared in a water-glycerol mixture while stirring by dissolving ε - aminocapronic acid, then zinc oxide, adding powdered ethylene diamine tetraacetic acid and after dissolved completely, adding a liquid solution of the antimicrobial substance in the water-glycerol mixture.
EFFECT: preparing the antiseptic drug with haemostatic action for wound cleaning.
2 cl, 9 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutics. There are developed agent for forming a biogel, biogels for hemostasis, wound closure, tissue engineering and targeted drug delivery. The agent contains a soluble carrier whereon a number of fibrinogen-binding groups is immobilised. The biogel that contains fibrinogen molecules and a number of soluble carriers applicable for intravenous and/or local administration; each carrier comprises a number of fibrinogen-binding groups immobilised on the carrier, and each fibrinogen molecule is bound to at least two fibrinogen-binding groups so that the fibrinogen molecules occurs to be bound to each other through the carriers by non-covalent bonds between the fibrinogen-binding groups and the fibrinogen molecules. The biogel containing fibrin monomers and a number of soluble carriers applicable for intravenous and/or local administration, wherein each carrier comprises a number of fibrinogen-binding groups immobilised on the carrier, while the fibrin monomers are bound to each other through the carriers by non-covalent bonds between the fibrinogen-binding groups and the fibrinogen monomers. The biogel containing fibrin and a number of soluble carriers applicable for intravenous and/or local administration, wherein each carrier comprises a number of fibrinogen-binding groups immobilised on the carrier with the fibrin monomers in fibrin are covalently bound to each other by peptide bonds, and the fibrin monomers in fibrin are bound to each other through the carriers by non-covalent bonds between the fibrinogen-binding groups and the fibrinogen monomers. A method for forming the biogel involving a contact of the fibrinogen molecules with a number of soluble carriers. A method for hemostasis by topical administration of the biogel at a haemorrhage or a wound. Using a number of soluble carriers applicable for intravenous and/or local administration. A pharmaceutical formulation for topical administration containing the biogel, agent or a number of soluble carriers.
EFFECT: using the declared invention enables preparing the agents requiring no toxic reagents to be used, have a minimal risk of allergic reactions, and are easy to prepare and use.
2 tbl, 4 dwg, 5 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to chemical-pharmaceutical industry, and represents a haemostatic agent used in small cuts, characterized by the fact that it is represented in the form of a match with its head having the following formulation, wt %: sodium chloride - 0.58 - 0.71; ε-aminocaproic acid - 2.14 - 3.25; purified water - 60.93 - 73.98; aluminium potassium sulphate - 19.65 - 32.84; lanolin - 1.77 - 2.92.
EFFECT: invention provides creating the agent which has the non-burning haemostatic agent when applied on the small cuts.
SUBSTANCE: group of inventions refers to medicine and aims at conducting the endoscopic hemostasis in gastric-duodenal hemorrhages. For the purpose of conducting the hemostasis, the capillary hemostasis liquid "Hemostab" is used and accompanied by the injection compression infiltration of paravasal and periulcerous regions. "Hemostab" is introduced within a hemorrhage point that is followed by the argon-plasma coagulation.
EFFECT: using the declared group of inventions is effective for the hemostasis in gastric-duodenal hemorrhages; it has the positive local effect on the clinical course of the pathological process, reduces the length of recovery of the defects caused the hemorrhage with no toxicity of the above preparation and no allergies.
1 ex, 3 dwg, 6 cl
SUBSTANCE: reparative-reconstructive stage of the oviduct operation is followed by introducing an indigo carmine coloured saline into the abdominal cavity. Catheters are placed transvaginally into the uterine cavity within internal openings of the oviducts to be fixed to the inner thighs. That is followed by an intraoperative two-sided block of mesosalpinx within the isthmic oviduct by introducing an anaesthetic 2.0-3.0 ml. The postoperative period involves a two-sided block of a round ligament of the uterus by introducing an anaesthetic 10.0 ml every 4-6 hours. If observing the coloured solution in the catheter 24 hours later, the preserved oviduct transport function is diagnosed. If observing no inflow of the coloured solution into the catheters, the oviduct transport dysfunction is diagnosed.
EFFECT: more reliable diagnosis of the oviduct transport dysfunction, including the intramural portion by eliminating spasms of corners of the uterus.
SUBSTANCE: method involves introducing the preparation Cytoflavin. A mixture of therapeutic substances consisting of Cytoflavin 5.0 ml and 0.5% Novocaine 5.0 ml is introduced by lymphotropic interstitial injection in the anteriolateral or posteriolateral surface of the upper or middle segments of the shin after preliminary local anaesthesia of the injection area with 0.5% Novocaine 5.0 ml.
EFFECT: method provides more effective treatment of obliterating diseases of lower extremity arteries, manages or relieves rest pains, increases a pain threshold, enlarges a painless walking distance, presents an alternative to the intravenous route of administration of Cytoflavin, causes no post-infusion headaches.
FIELD: veterinary medicine.
SUBSTANCE: method comprises administering to the animals in the supine position, in addition to the general course of treatment during 5-7 days of 0.5% novocaine solution, depending on the age at a dose of 1.0-2.0 ml per kg of live body weight with adding 1.0 g of cefazolin in the region of the round ligament of the liver, the administration of novocaine solution with cefazolin. The injections are carried out in a cat in the supine position, at the point at 4.8-5.2 cm cranial to the umbilicus along the sagittal line of the abdomen in the dorsal direction. The puncture is made with the needle to the depth of 0.9-1.1 cm to the feeling of characteristic falling of the needle under the aponeurosis of the rectus abdominis muscle. The preparation solution is administered under pressure.
EFFECT: method is simple to use and highly effective for the treatment of acute hepatosis in cats.
2 tbl, 1 ex
FIELD: chemistry, pharmacology.
SUBSTANCE: pharmacological composition for preparing drug forms in form of powder, solution or bandage consists of biocompatible film-generating polymer polyvinylpyrrolidone (Mm 20000), iodine and Novocain, taken in quantities, given in the invention formula. Pharmaceutical composition is intended for processing wound surface and treatment of burns. Composition possesses antiseptic, local anesthetic and wound-healing action.
EFFECT: water-soluble form of medication possesses high anti-burn activity, low cost and long storage term.
SUBSTANCE: invention relates to medicine, namely to surgery, and can be applied for treatment of combined and cavernous hemangiomas of difficult anatomical localisation. For this purpose hormonal therapy and influence by cold on a pathological focus are performed. Hormonal therapy is carried out by infiltration of hemangioma tissue with prednisolone in a dose 3-4 mg per 1 kg of body weight, dissolved in 2% solution of novocaine with ratio 1:1, by 1-4 injections. As a cold agent applied is snow of carbonic acid, from which a cylinder with diameter 0.5-0.7 cm is formed. The cylinder base is placed on the periphery of a tumour in 1-6 points alternately. Exposition of application in each point constitutes 10-12 seconds.
EFFECT: implementation of the method ensures extension of arsenal of means for treating hemongiomas of the given localisation and a possibility of carrying out sparing physiological cryoapplications with high anaesthetic effect and good cosmetic and functional results.
SUBSTANCE: invention refers to medicine, namely to gastroenterology, and may be used for treating pain syndrome accompanying pancreatitis in oesophagogastroduodenoscopy. That is ensured by an endoscopic gastric and duodenal pH-metry; and if the derived pH in a duodenal cap and outside is 5 or less, 4% sodium bicarbonate 20-60 ml is introduced intraduodenally, and if the pH value is more than 5, 0.25% novocaine 20-60 ml is introduced.
EFFECT: method enables reducing pain syndrome in 95% patients suffering pancreatitis.
2 ex, 3 dwg, 2 tbl
SUBSTANCE: suppurative focus is exposed, drained and sanitated. That is followed by the postoperative subcutaneous administration of drug preparations on the border of middle and lower thirds of leg according to the following regimen: First Lydase dissolved in 0.25% novocaine 2 ml is administered first. After 5-10 minutes, third-generation Cephalosporin 1000 mg dissolved in 0.25% novocaine 5 ml for 5 days is administered. That is followed by administering 4 injections of derinate 5 ml every two days.
EFFECT: invention provides the lymphatic canal sanitation and the recovery of its function with reducing a quantity of recurrences and postoperative complications in the patients with paraproctitis.
SUBSTANCE: invention refers to medicine, namely medicine, and may be used for treating urethral syndrome in females with using the antibacterial preparation gentamycin. Gentamycin is introduced into a urethral wall in the amount of 80 mg dissolved in anaesthetic solution 2 ml. The above preparation is introduced in parallel with the urethral wall. The anaesthetic is presented by 0.25% Novocaine. That is followed by a vulvar exposure to an infrared laser light at wave length 0.82 mcm, frequency 3000 Hz, and power 10 mWt. A procedure length makes 5-6 minutes; the therapeutic course is 8-10 procedures.
EFFECT: method is well tolerated, accessible and high effective by providing the high gentamycin concentration in the area of inflammation and stimulating repair processes.
1 ex, 2 tbl, 1 dwg
SUBSTANCE: invention refers to medicine and aims at treating amnestic syndrome. A local anaesthesia is applied by infiltration of the tissues surrounding the external auditory canal with 0.5% novocaine along an anteromedial surface of the mastoid process bypassing the eardrum directly into the ear. The therapeutic effect is implemented by administering 1 g of streptomycin dissolved in 1 ml of physiological saline, intratympanic from one or both sides once a day every 2-3 days, with the manipulations performed 2 to 5 times per a course during 10-20 days. The transcranial exposure is generated by direct electric current at the intensity of 200-600 mA in the mid-temporal area of the head for 20-40 minutes daily for 8-10 days, repeated 2-3 times every 1-2 months. The electric exposure is generated by applying lead electrodes with each electrode having an area of 400-600 mm.
EFFECT: method enables improving associative cortex activity and improving the clinical effectiveness.
3 cl, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to veterinary science. The agent contains, wt %: wildflower honey 3.0-5.0, pine turpentine 5.0-8.0, melted (cow) butter 12.0-15.0, anaesthesine 0.5-1.0, glycerol 0.5-1.5, ethanol 20.0-25.0, potassium iodide 2.0-2.5, salicylic acid 3.0-5.0, 9% vinegar 6.0-8.0, Novocaine (powder) 1.0-1.5, distilled water - the rest.
EFFECT: use of the declared agent enables higher clinical effectiveness in actinomycosis and necrobacteriosis, improved immunobiological properties of animal's body, reduced length of recovery.
1 tbl, 4 ex
FIELD: medicine, oncology.
SUBSTANCE: the present innovation deals with treating patients with uterine cervix cancer with relapses in parametral fiber and in case of no possibility for radical operative interference and effect of previous radiation therapy. During the 1st d of therapy one should intravenously inject 30 mg platidiam incubated for 1 h at 37 C with 150 ml autoblood, during the next 3 d comes external irradiation per 2.6 G-r. During the 5th d of therapy one should introduce the following composition into presacral space: 60 ml 0.5%-novocaine solution, 1 ml hydrocortisone suspension, 2 ml 50%-analgin solution, 1 ml 0.01%-vitamin B12 solution, 1.6 g gentamycine, 800 mg cyclophosphan, 10 mg metothrexate. These curative impacts should be repeated at mentioned sequence four times. The method enables to decrease radiation loading and toxic manifestations of anti-tumor therapy at achieving increased percent of tumor regression.
EFFECT: higher efficiency of therapy.