Method of production of microemulsion cleaning cosmetic containing polyols, and agent obtained in this method

FIELD: cosmetology.

SUBSTANCE: invention is a method of production of microemulsion cleaning agent of epicutaneous application, comprising mixing the nonionic surfactants with the oil components to homogeneous state, and adding water and polyols, characterised in that 40-60 wt % water is preliminary mixed with polyols, it is added into the mixture of nonionic surfactants with oil components, stirred to homogeneous state, and the remaining quantity of water is added, at that the process is carried out under vigorous stirring and at room temperature.

EFFECT: obtaining cleanser in the form of stable microemulsion that has the advantages of oil cleanser with high cleaning properties while simultaneous improving its permeability and moisture capacity, providing restoring elasticity and regenerative capacity of the skin without leaving an unpleasant oil film on the skin surface.

7 cl, 11 ex, 1 tbl

 

The present invention relates to the field of cosmetology and relates to a method of obtaining a microemulsion cleansing cosmetic products containing polyols.

As is known, the skin proper care, then it will remain healthy and will look young for a long time.

One of the most common problems associated with the skin is dry.

Reasons contributing to the development of dry skin, a lot. Among the exogenous (external) factors - frequent contact with the cleaning and detergents. Among endogenous (internal) factors, disruption of water-retaining system of the stratum corneum (damage lipid barrier, lack of sebum, the deficit of the components of natural moisturizing factor).

Cleansing and detergent in contact with the stratum corneum, may impair water-retaining structure and the ability of the stratum corneum to retain water decreases.

On the other hand, the current trend towards sustainable decorative cosmetics, incorporating various elastomeric mixture, require ever more efficient and powerful cleansers, since the traditional tools cannot cope with this task.

The lack of proper cleansing causes a number of problems, such as the appearance of comedones, acne, premature aging to the I.

There are two main types of cleansers skin: soap - traditional detergents, representing a combination of surface-active substances (surfactants) and syndey, which contains softening ingredients (oils), counteracting the drying action of the surfactant.

And all modern cleansing compositions are divided into water and oil.

Example water cleansers are lotions and liquid gels, as oil funds are compositions cream type. Water resources are the problems associated with cleansing and moisturizing ability, so in recent years become more and more widespread oil cleanser.

They are great to remove any traces of makeup, but have the major disadvantage is the resulting unpleasant oily film on the skin after use.

So, it is known cosmetic milk containing stearin, stearate, lanolin, oil, perfume and water and, optionally, distilled monoglycerides, synthetic alcohols, microcrystalline cellulose, PENTAERYTHRITE, perfume oil, medical petrolatum, Tocopheryl acetate, potassium hydroxide, paraform, ethyl alcohol (U.S. Pat. RF 2073506).

Known cleansing cosmetic gel, which as active principles contains extracts of fruits of pineapple, papaya fruit, kiwi, abstractcontainer algae, green tea extract, Foundation and auxiliary substances (U.S. Pat. RF 2189245).

Famous facial wash that contains olive oil, stearin cosmetic, triethanolamine, stearates polyhydric alcohols, preservatives, flavoring and water, and as a fatty basis it also contains coconut oil, as stearates polyhydric alcohol is glycerol monostearate and oleate PEG-400, as preservatives - paraform and 2-bromo-2-nitropropanediol-1,3 and additionally emulsion waxes, glycerin, urea, Trilon B and surfactant sodium dodecyl sulfate and diethanolamide fatty acids of coconut oil (U.S. Pat. RF 2111739).

On the other hand, it is known the use of cosmetic and pharmaceutical preparations in the form of micro-emulsions (U.S. Pat. RF 2381023).

Microemulsions are isotropic, low-viscosity, transparent (or translucent) system of oil, water and surfactants (surfactant), often in combination with a co-surfactant.

Are formed under certain conditions, when the oil droplets in the emulsion can be quite small, due to which they will not refract light and, therefore, capable of forming a transparent system. This kind of variance is called the microemulsion, which is transparent due to the very small droplet size (approximately <100 nm).

Microemulsions require against the sustained fashion a large number of surfactants to stabilize a large interfacial surface, forming nanocable and demanding to adding a co-surfactant. In addition, they have a large solubilities capacity, thereby capable of solubilisate longest amount of oil or water and/or BAD (depending on the form of drops), in contrast to the usual solution of micelles.

Microemulsions - a dynamical system with continuous interfacial surface. Structurally, they are divided into oil-in-water (m/V), water-in-oil (W/m) and bicentenaria microemulsions. In microemulsions/m water droplets dispersed in a continuous oil phase, and in the case of microemulsion m/oil droplets dispersed in a continuous aqueous phase. In systems where the amount of water and oil equivalent, are formed bicentenary region of the microemulsion. In all three types of microemulsions interfacial surface stabilized by appropriate combinations of surfactants and/or co-surfactant.

Wide dissemination of microemulsions, of course, depends on the fact that at the macroscopic level they are homogeneous, but are heterogeneous in submicroscopic scale. The surfactant molecules are formed topologically ordered interfacial film, which due to its amphiphilicity forced to navigate in the microscopic surface water/oil. The nature and properties of these microscopic interfacial films important for microemulsions, as in a is m, and in particular, namely the most interesting features of microemulsions is their microstructure.

The main characteristic of this film is the average value of its curvature. By definition, the curvature of the amphiphilic film surfactant is positive, if it surrounds/contains oil (microemulsion m/C), and negative if it surrounds water microemulsion/m). Parameters which depend on the curvature of the amphiphilic film are: temperature, composition of the film itself, i.e. the dependence on nature, surfactants, electrolytes, etc.

The average curvature (N) is determined experimentally, methods of dispersion.

For temperature-sensitive systems, the composition of the oil-in-water microemulsions are formed at a low temperature, and with increasing formation of micro-emulsions water-in-oil due to changes in the average magnitude of the curvature (N) amphiphilic film. At low temperatures the amount of polar groups (heads) of the surfactant is greater than the size of the hydrophobic chains, which bend amphiphilic film around oil. With increasing temperature the amount of the polar groups of the surfactant is compressed due to dehydration (dehydration), whereas the size of the hydrophobic chains increases due to the increasing number of chain conformations and the increasing penetration of molecules of oil. Thus, (N) gradually change which is from H> 0 to N<0, that is, from the structures of the oil in water structures water in oil, through the structures of planar amphiphilic film, when N=0.

For other systems the change in the average value of the curvature of the interfacial film can be observed when varying the mass fraction of alcohol (increase), which acts as a co-surfactant. Knowing that the polar groups of the alcohols is less than the polar group of the surfactant (in this case, describes derivatives of esters of sugars), it can be noted that increasing the fraction of alcohol in a mixed border film causes a decrease in the average curvature from N>0, for microemulsions m/b to N<0 for microemulsions in/m

The resulting microstructure is a droplets or swollen micelles, consisting of oil or water centre, i.e. oil-in-water droplet or water-in-oil droplet, or nicontinamide phases that are formed by amphiphilic film, depending on the nature of surfactants and external conditions. Each such microcaps, forward or reverse type, surrounded by a mixed interfacial film in which the molecules of surfactant and co-surfactant alternate.

Molecules co-surfactants play an important role in the formation of such a unique microstructure. Incorporating into the surfactant monolayer, they thereby reduce the surface tension and the size dispersion of the droplets decreases. In addition, the presence of co-PA is doing interfacial film more flexible, which leads to the formation bycontinuing structures, which are characteristic of microemulsions.

"Spongy" structure bycontinuing systems leads to the formation of areas of oil and water, randomly organized and forming mutually penetrating the system, separated mobile amphiphilic surface. The structure of the microemulsion can be discontinuous or mutually continuous, depending on the concentration of oil, aqueous phase and surfactant.

The main advantages of microemulsions over other systems

Table 1
Comparison of microemulsions with other colloidal carriers
Microemu lsiiMicelleEmulsionLiposomesNano-emulsion
Thermodynamic stabilityYesYesNoNoTending to her
The range of particle sizes~50<10 nm0.5 to 5 nm of 0.025-25 nm20-200 nm
The content of surfactant>10%<5%1-20%-<10%
AppearanceP*P*M*M*PL*
P - transparent, M, muddy, PL - translucent

thermodynamic stability of microemulsions promotes the formation of stable colloidal system that holds this state for a long time.

Different structures of microemulsions can capture hydrophilic and hydrophobic BAD either individually or in combination, which makes them universal carriers and carriers of biologically active substances, increasing the capacity of their bioavailability.

Microemulsions are able to penetrate through skin and mucosal barriers, leading to increased therapeutic efficacy of biologically active substances.

The inherent thermodynamic stability of microemulsions, a large interfacial area and the small size of the droplets allows them hanging the ü as templates for surface synthesis of pharmaceutical nanoparticles, such as solid lipid nanoparticles and nanosuspension. In addition, microemulsions are nanoreactors, which can be adapted for the manufacture of pharmaceutical nanomaterials.

However, along with the many advantages of microemulsions, they have very serious disadvantages: unstable, often stratified, methods for their production is very complex, as in the formation of microemulsions, adding water to the mixture of surfactant and oil, there are various phase transitions. You can observe the transitions from phase micellar solutions to the phase reverse micellar solutions, to the lamellar phase, multicomponent phase (bicentenary patterns) and to the two-phase region.

Known methods for producing such microemulsions method of temperature inversion phase (U.S. Pat. RF 2381023).

At a certain temperature, some emulsion-based nonionic surfactants (nonionic surfactants) change their structure, namely the observed transition emulsion of m/emulsion/M. This process is reversible, and this means that upon cooling the emulsion below the so-called temperature inversion phase (TYPHOID), again leads to the formation of emulsion m/century Formation of the microemulsion through the FEVER often leads to the formation of a very good and stable for debt emulsions with particle sizes IU is 1 nm. The main requirement that must be fulfilled, is the formation of microemulsions between emulsion m/and/m Only, the formation of the blue emulsion FEVER with a range of particles of submicron size.

The basic method TYPHOID can be used to obtain microemulsions. If the microemulsion-based nonionic surfactants, in the process of microemulsion at room temperature can be obtained microemulsion m/C. With increasing temperature according to the properties of nonionic surfactants, they become less hydrophilic, resulting in inversion of the phases and the transition from microemulsions m/in/m

When such a transition can occur clouding of the system, i.e. the formation of emulsions, which upon further cooling, again returned in original condition - transparent/opalescense system microemulsions, as a rule, more stable and with a higher transparency than the original.

When creating microemulsions method TYPHOID indicator temperature must be strictly controlled for a specific product.

The disadvantage of TYPHOID is its high energy consumption, since to obtain a microemulsion in a similar way, first it is necessary to heat the mixture of surfactants, oil components to a temperature of merge phases (40-99°C). Then the mixture must ohla who raised to room temperature.

The technical task of the present invention is to provide opportunities for cleansing cosmetics skin actions in the form of a microemulsion, the development of the method of receipt of such funds.

The technical goal of the invention is providing a method to obtain cleansing products in the form of a stable microemulsion with the benefits of oil cleansing with high cleansing properties while increasing its absorption and water holding capacity, which restores elasticity and regenerative capacity of the skin, does not leave an unpleasant oily film on the skin surface, as well as funds received in this way.

To achieve this goal, a method for obtaining a microemulsion cleaning cosmetics skin application comprising a mixture of nonionic surfactants, oil components until smooth and add water and polyols, with pre-mixed 40-60 wt.% water with polyols, add it to the mixture of nonionic surfactants, oil components, mix until smooth and enter the remaining amount of water, when this process is carried out under vigorous stirring and at room temperature (20-23°C).

As neinogennye surface is IDT-active agents (nonionic surfactants), it is preferable to use PEG-8 Glyceryl of Isostearate, and/or PEG-20 Glyceryl of Isostearate, and/or PEG-8 Caprylic/Capric Triglycerides.

As the polyols, it is preferable to use butyleneglycol and/or dipropyleneglycol.

As the oil component, it is preferable to use cetyl ethylhexanoate, and/or Cetearyl octanoate, and/or Cyclopentasiloxane.

Thus, as nonionic surfactants can be used ethoxylated glyceriae esters of fatty acids and/or propilenglikolem esters of fatty acids and their derivatives, as well as oil components, you can use vegetable or synthetic oils.

As vegetable oils can be used sunflower oil and/or olive oil and/or soybean oil and/or canola oil and/or almond oil and/or jojoba oil and/or corn oil, and/or avocado oil and/or castor oil and/or sesame oil.

As synthetic oils you can use isopropylmyristate, and/or tetrachromat, and/or isocetyl isostearate, and/or Cetearyl octanoate, and/or octyl isopleth, and/or silicone oil.

The authors propose to protect cleansing facial cosmetic cutaneous application, obtained by the proposed method.

Preferably the cleansing cosmetic cutaneous application contains, in wt.%:

Nonionic surfactants (nonionic surfactants)20-30
Oil components10-68
The polyols4-10
Water100

When this cleansing cosmetic preparation may additionally contain active additives, pH regulators, such as plant extracts, vitamins, arginine or triethanolamine, citric or lactic acid.

The proposed method is as follows:

First mixed nonionic surfactants (nonionic surfactants) with oil components, then add water and polyols.

In this advance in a separate container prepare a solution of polyols with water. The amount of water in this case is 40-60 wt.%, in the calculation of the total mass of water in the medium. Then, under vigorous stirring, at room temperature, add the resulting solution to a pre-mixture of surfactants, oil components, and then adding to the mixture of the remaining quantity of water.

As the nonionic surfactants can be used a mixture of nonionic surfactants, namely ethoxylated glyceriae esters of fatty acids obtained by the accession of ethylene oxide and propylene is Nikolaeva esters of fatty acids and their derivatives obtained by the esterification of fatty acids with propylene glycol.

The content in the structure of ethoxylated nonionic surfactants groups increases their solubilizing ability, because the presence of such groups makes the substance more hydrophobic and contributes to its collapse in the excess oil. The remaining mixture of surfactants are more hydrophilic than the primary surfactant. To intensify the hydrophilic or hydrophobic properties of nonionic surfactants by using raise the temperature: when the temperature of the nonionic surfactants is more lipophilic.

This behavior is opposite ionic surfactants, which, on the contrary, become more hydrophilic with increasing temperature. The addition of electrolytes makes them more hydrophobic due to the increasing competition of ions of salts with protivoanemi and polar groups.

Another important parameter for SAS when creating a microemulsion is the value of the products HLB. Its value can be judged on the type of microemulsion - oil-in-water (m/W) or water-in-oil (W/m).

Surfactants with low products HLB preferred microemulsions/m, while surfactants with high value products HLB preferred microemulsions m/C. the Most effective is a combination of hydrophilic surfactants with a high products HLB values and lipophilic surfactants with a low value products HLB to obtain a microemulsion.

In our case, preferred are products HLB values in the range from 6 to 14.

The lipophilic group of the nonionic surfactants, ispolzuemykh for the preparation of compositions, can be linear and/or branched, saturated and/or unsaturated alkyl type, preferably C8-C22 carbon atoms, as it contributes to the increase in the average area of a surfactant with boundary layer. In the framework of the present invention can be used, for example, glyceriae esters of polyethylene glycol ezoterikovou, Caprylic and capric acids.

The authors used PEG-8 Glyceryl of Isostearate, PEG-20 Glyceryl of Isostearate and PEG-8 Caprylic/Capric Triglycerides.

The quantitative content of the nonionic surfactants to create the composition varies in the range from 20 to 30 wt.%, calculated on the total weight of the composition.

The use of surfactants upon receipt of the microemulsion is necessary to reduce the magnitude of the interphase tension at the boundary of the oil-in-water. Very often surfactant itself may not result in the necessary reduction of the interphase surface tension, therefore, to use a mixture of nonionic surfactants are the most desirable. In this invention to obtain a cleansing cosmetic composition in the form of a microemulsion, a mixture of two nonionic surfactants in a ratio of 2:1.

Moreover, lower values of the interphase surface tension helps add to the system of so-called solvents. They can serve as polyhydric alcohols - polyols.

As polyols in the considered image is hetenyi use - butyleneglycol, dipropyleneglycol.

The quantitative content of the polyol in the aqueous phase of the composition is from 4 to 10 wt.%, calculated on the total weight of the composition. If the content is less than the above range, the effect of the present invention, in some cases, it may be difficult, while if the content is higher than the above range, the applicability in some cases may be degraded due to unpleasant, irritating effect on the skin.

Once in the system, polyols adsorbiruta at the interface with surfactant, thereby changing the density of their packing, which is important.

With increasing hydrocarbon chain (n-butanol<n-pentanol<n-hexanol<n-heptanol) increases the lipophilicity of the polyols. Lipophilic effect of such alcohols, such as n-butanol, such as long-chain alcohols portion of the hydrocarbon chains swells more than the polar part (the head). While the hydrophilic effect is achieved, so-called solvent - ethylene glycol, butoxyethanol. In homological series of polar groups such short-chain alcohols swell better (more)than the tails. It turns out that adding the polyols, it is possible to facilitate the formation of micro-emulsions water-in-oil or oil-in-water.

Polio the s adsorbed at the interface, thus reducing the stiffness of the interphase boundaries, and inhibit the formation of lamellar liquid crystals.

As the oil component of the composition can contain at least one non-polar or polar oil component, which can be natural or synthetic. Polar oil components can be selected from vegetable oils, such as sunflower oil, olive oil, soybean oil, rapeseed oil, almond oil, jojoba oil, corn oil, avocado oil, castor oil, sesame oil, and synthetic - isopropylmyristate, tetrachromat, isocetyl isostearate, Cetearyl octanoate, octyl isopleth and/or silicone oils, which may be cyclic or linear, for example a linear dimethylpolysiloxane. Non-polar oil components can be selected from liquid paraffin oils, isoparaffin oils, for example, isohexadecane, hydrogenated polyalkenes.

In view of the present invention, namely, the cleansing of the microemulsion, the choice of the oil components is very important. Effective cleansing composition should contain a high percentage of oil components, however, not to leave traces of stickiness after washing away. Therefore, the recommended input oil components for this composition is from 10 to 68 wt.%, calculated on the total wt is the song.

In this invention, the authors used as oil components cetyl ethylhexanoate, and/or Cetearyl octanoate, and/or Cyclopentasiloxane.

Example 1, 2 and 3 demonstrate the cleansing composition in the form of microemulsions.

The resulting compositions are transparent, liquid system, stable for 3 months at room temperature (20-23°C), which corresponds to the properties of the microemulsions described above.

Example 1.

The entire process is conducted under normal conditions, the temperature of 20-23°C.

16.7 g of PEG-8 Glyceryl of Isostearate and 8.3 g of PEG-20 Glyceryl of Isostearate, represent nonionic surfactants defined above, is mixed with heavy use of mixer until smooth. Then in the resulting homogeneous mixture was added 8 g Cetearyl of octanoate and 12 g of Cyclopentasiloxane. Again include a mixing device and high speed stirred to obtain a homogeneous mixture. In a separate container parallel to prepare a solution of polyols consisting of 24.5 g of Water and 3 g of Butyleneglycol and 3 g of Dipropyleneglycol. The resulting solution of polyol added to the homogeneous mixture of surfactants, oil components under vigorous stirring. Intensively stirred for 10-15 minutes, but visually you can see the formation of a transparent solution turbid. After when int is newnam stirring, add the remaining estimated amount of water for this composition. At this stage you can enter a water-soluble active additives, pH regulators.

Example 2.

The entire process is conducted under normal conditions, the temperature of 20-23°C. 13.3 g of PEG-8 Glyceryl of Isostearate and 6.7 g of PEG-20 Glyceryl of Isostearate, represent nonionic surfactants defined above, is mixed with heavy use of mixer until smooth. Then in the resulting homogeneous mixture was added 8 g Cetearyl of octanoate and 12 g of Cyclopentasiloxane. Again include a mixing device and high speed stirred to obtain a homogeneous mixture. In a separate container parallel to prepare a solution of polyols consisting of 28 g of Water and 2 g of Butyleneglycol and 2 g of Dipropyleneglycol. The resulting solution of polyol added to the homogeneous mixture of surfactants, oil components under vigorous stirring. Intensively stirred for 10-15 minutes, but visually you can see the formation of a transparent solution turbid. After intensive stirring, add the remaining estimated amount of water for this composition. At this stage you can enter a water-soluble active additives, pH regulators.

Example 3.

The entire process is conducted under normal conditions, the temperature of 20-23°C. 20 g of PEG-8 Glyceryl of Isostearate and 10 g of PEG-8 Caprylic/Capric Triglycerides represent the battle of nonionic surfactants, as defined above, is mixed with heavy use of mixer until smooth. Then in the resulting homogeneous mixture was added 4 g of Cetyl of ethylhexanoate and 6 g of Cyclopentasiloxane. Again include a mixing device and high speed stirred to obtain a homogeneous mixture. In a separate container parallel to prepare a solution of polyols consisting of 26 g of Water and 4 g of Butyleneglycol and 4 g Dipropyleneglycol. The resulting solution of polyol added to the homogeneous mixture of surfactants, oil components under vigorous stirring. Intensively stirred for 10-15 minutes, but visually you can see the formation of a transparent solution turbid. After intensive stirring, add the remaining estimated amount of water for this composition. At this stage you can enter a water-soluble active additives, pH regulators.

As a result, three of the above examples was obtained microemulsions, which are characterized by the following properties: represent a clear liquid, stable at room temperature (20-23°C) for 3 months. Visual evaluation was carried out after 3 months of exposure of samples in a heating Cabinet. All samples were turbid and was observed stratification. When cooled to room temperature (20-23°C) samples spent the NGOs spontaneously became transparent, that is, the acquired properties of the microemulsion, stable in time.

All samples microemulsions were percentagevalue at 6000 rpm for 5 minutes. All samples were stable.

In the case of changing the order of mixing, add features formed turbid solutions, which are stratified, i.e. the formation of microemulsions is not happening according to the properties of the microemulsions described above.

I. Consider the similar case of the example compositions No. 1.

The entire process is conducted under normal conditions, the temperature of 20-23°C. 16.7 g of PEG-8 Glyceryl of Isostearate and 8.3 g of PEG-20 Glyceryl of Isostearate, represent nonionic surfactants defined above, is mixed with heavy use of mixer until smooth. In separate tanks in parallel, prepare a solution of polyols consisting of ½ part Water, in the calculation of the total amount of water for this composition, and 3 g of Butyleneglycol and 3 g of Dipropyleneglycol, as well as a mixture of oil components by mixing 8 g Cetearyl of octanoate and 12 g of Cyclopentasiloxane. Then surfactant to the mixture add a solution of polyols consisting of 3 g of Butyleneglycol, 3 Dipropyleneglycol and 24.5 g of Water, with vigorous stirring. After the resulting homogeneous mixture is added a mixture of oil components under vigorous stirring. Intensively AC who're asked for 10-15 minutes. After intensive stirring, add the remaining estimated amount of water for this composition. At this stage you can enter a water-soluble active additives, pH regulators.

II. Options for obtaining a microemulsion in example No. 1 without preparation of a solution of polyols with ½ part Water, in the calculation of the total amount of water for this composition.

The entire process is conducted under normal conditions, the temperature of 20-23°C. 16.7 g of PEG-8 Glyceryl of Isostearate and 8.3 g of PEG-20 Glyceryl of Isostearate, represent nonionic surfactants defined above, is mixed with heavy use of mixer until smooth. Then in the resulting homogeneous mixture was added 8 g Cetearyl of octanoate and 12 g of Cyclopentasiloxane. Again include a mixing device and high speed stirred to obtain a homogeneous mixture. Then in the resulting homogeneous mixture with heavy use of mixing devices add the calculated amount of water and mix. Next, add 3 g of Butyleneglycol and 3 g of Dipropyleneglycol and intensively stirred for 10-15 minutes. At this stage you can enter a water-soluble active additives, pH regulators.

In the proposed methods I and II receive turbid solutions, unstable in time (delamination occurs in ECENA several hours). This suggests that to obtain a microemulsion of these methods is impossible, and that the order of mixing the components of the microemulsion is an important criterion for its receipt.

It is important to note that not only changing the order of mixing of the components affects the formation of the microemulsion, and the process conditions of mixing of the components, in particular if we start the process with heating (above 20-23°C) and/or with cooling (below 20-23°C).

Example 4, 5, 6, 7 and 8 illustrate compositions that are not microemulsions. Song data demonstrate the importance of the surfactant concentration in the composition of the microemulsion and its relationship with other components. In the present compositions, the surfactant content is less than 20 wt.%, calculated on the total weight of the composition, which is not recommended to obtain cleansing products in the form of a microemulsion. The amount of oil components in the compositions vary and are value - 20 wt.%, calculated on the total weight of the composition, and 15 wt.%, calculated on the total weight of the composition is 10 wt.%, calculated on the total weight of the composition is 10 wt.%, calculated on the total weight of the composition, and 8 wt.%, calculated on the total weight of the composition, respectively.

The resulting compositions are turbid solutions, stratifying within a few hours up to a month at room temperature (20-23°C). Such certificate is of listwhat about which song data are not microemulsions and that education cleansing compositions in the form of microemulsions requires that the quantitative content of the surfactant was varied in the range from 20 to 30 wt.%, calculated on the total weight of the composition.

Example 4.

The entire process is conducted under normal conditions, the temperature of 20-23°C. 10 g of PEG-8 Glyceryl of Isostearate and 5 g PEG-20 Glyceryl of Isostearate, represent nonionic surfactants defined above, is mixed with heavy use of mixer until smooth. Then in the resulting homogeneous mixture was added 8 g Cetearyl of octanoate and 12 g of Cyclopentasiloxane. Again include a mixing device and high speed stirred to obtain a homogeneous mixture. In a separate container parallel to prepare a solution of polyols consisting of 27,5 Water and 5 g of Butyleneglycol and 5 g of Dipropyleneglycol. The resulting solution of polyol added to the homogeneous mixture of surfactants, oil components, with vigorous stirring. Intensively stirred for 10-15 minutes. After intensive stirring, add the remaining estimated amount of water for this composition. At this stage you can enter a water-soluble active additives, pH regulators.

Example 5.

The entire process is conducted under normal conditions, the temperature of 20-23°C. 9 g is AG-8 Glyceryl of Isostearate and 4 g of PEG-8 Caprylic/Capric Triglycerides represent nonionic surfactants defined above, is mixed with heavy use of mixer until smooth. Then in the resulting homogeneous mixture was added 6 g of Cetyl of ethylhexanoate and 9 g of Cyclopentasiloxane. Again include a mixing device and high speed stirred to obtain a homogeneous mixture. In a separate container parallel to prepare a solution of polyols consisting of 32 g of Water and 4 g of Butyleneglycol and 4 g Dipropyleneglycol. The resulting solution of polyol added to the homogeneous mixture of surfactants, oil components under vigorous stirring. Intensively stirred for 10-15 minutes. After intensive stirring, add the remaining estimated amount of water for this composition. At this stage you can enter a water-soluble active additives, pH regulators.

Example 6.

The entire process is conducted under normal conditions, the temperature of 20-23°C. 10 g of PEG-8 Glyceryl of Isostearate and 5 g PEG-20 Glyceryl of Isostearate, represent nonionic surfactants defined above, is mixed with heavy use of mixer until smooth. Then in the resulting homogeneous mixture was added 4 g Cetearyl of octanoate and 6 g of Cyclopentasiloxane. Again include a mixing device and at high rpm mix to obtain omogenei mixture. In a separate container parallel to prepare a solution of polyols consisting of 32,5 Water and 5 g of Butyleneglycol and 5 g of Dipropyleneglycol. The resulting solution of polyol added to the homogeneous mixture of surfactants, oil components under vigorous stirring. Intensively stirred for 10-15 minutes. After intensive stirring, add the remaining estimated amount of water for this composition. At this stage you can enter a water-soluble active additives, pH regulators.

Example 7.

The entire process is conducted under normal conditions, the temperature of 20-23°C. 10 g of PEG-8 Glyceryl of Isostearate and 5 g PEG-20 Glyceryl of Isostearate, represent nonionic surfactants defined above, is mixed with heavy use of mixer until smooth. Then in the resulting homogeneous mixture was added 3.2 g of Cetearyl of octanoate and 4.8 g of Cyclopentasiloxane. Again include a mixing device and high speed stirred to obtain a homogeneous mixture. In a separate container parallel to prepare a solution of polyols consisting of 34,5 g of Water and 4 g of Butyleneglycol and 4 g Dipropyleneglycol. The resulting solution of polyol added to the homogeneous mixture of surfactants, oil components under vigorous stirring. Intensively stirred for 10-15 minutes. After vigorous stirring dobavlyaetsya the estimated amount of water for this composition. At this stage you can enter a water-soluble active additives, pH regulators.

Example 8.

The entire process is conducted under normal conditions, the temperature of 20-23°C. 6.7 g of PEG-8 Glyceryl of Isostearate and 3.3 g of PEG-20 Glyceryl of Isostearate, represent nonionic surfactants defined above, is mixed with heavy use of mixer until smooth. Then in the resulting homogeneous mixture was added 4 g Cetearyl of octanoate and 6 g of Cyclopentasiloxane. Again include a mixing device and high speed stirred to obtain a homogeneous mixture. In a separate container parallel to prepare a solution of polyols consisting of 37 g of Water and 3 g of Butyleneglycol and 3 g of Dipropyleneglycol. The resulting solution of polyol added to the homogeneous mixture of surfactants, oil components under vigorous stirring. Intensively stirred for 10-15 minutes. After intensive stirring, add the remaining estimated amount of water for this composition. At this stage you can enter a water-soluble active additives, pH regulators.

Example 9, 10 and 11 show the influence of the concentration of polyols in the formation of microemulsions. In the case of obtaining a cleanser in the form of a microemulsion recommended input polyols is 4-10%. When the content of the glycol in which notizie is 13 wt.%, calculated on the total weight of the composition, i.e. above the recommended values, the resulting composition shows all the properties characteristic of microemulsions, transparent, stable system over time. The main disadvantage of this composition - eye irritation due to the high content of glycol, which is unacceptable for cleansing cosmetics in the form of a microemulsion. In the case when the content of the glycol in the composition is 2 wt.%, calculated on the total weight of the composition, and 2.5 wt.%, calculated on the total weight of the composition, i.e. below the recommended values, then the resulting composition is a microemulsion, as it is a cloudy solution, stratifying time at room temperature (20-23°C).

Example 9.

The entire process is conducted under normal conditions, the temperature of 20-23°C. 13.3 g of PEG-8 Glyceryl of Isostearate and 6.7 g of PEG-20 Glyceryl of Isostearate, represent nonionic surfactants defined above, is mixed with heavy use of mixer until smooth. Then in the resulting homogeneous mixture was added 8 g Cetearyl of octanoate and 12 g of Cyclopentasiloxane. Again include a mixing device and high speed stirred to obtain a homogeneous mixture. In a separate container parallel to prepare a solution of polyols consisting of 23,5 g of Water and 6.5 g of Butyleneglycol and 6.5 g of Dipropyleneglycol. The resulting solution of polyol added to the homogeneous mixture of surfactants, oil components, with vigorous stirring. Intensively stirred for 10-15 minutes at this visually, you can see the formation of a transparent solution turbid. After intensive stirring, add the remaining estimated amount of water for this composition. At this stage you can enter a water-soluble active additives, pH regulators.

Example 10.

The entire process is conducted under normal conditions, the temperature of 20-23°C. 20 g of PEG-8 Glyceryl of Isostearate and 10 g of PEG-8 Caprylic/Capric Triglycerides, represent nonionic surfactants defined above, is mixed with heavy use of mixer until smooth. Then in the resulting homogeneous mixture was added 4 g of Cetyl of ethylhexanoate and 6 g of Cyclopentasiloxane. Again include a mixing device and high speed stirred to obtain a homogeneous mixture. In a separate container parallel to prepare a solution of polyols consisting of 29 g of Water and 1 g of Butyleneglycol and 1 g of Dipropyleneglycol. The resulting solution of polyol added to the homogeneous mixture of surfactants, oil components under vigorous stirring. Intensively stirred for 10-15 minutes. After intensive stirring, add the remaining estimated amount of water is for this composition. At this stage you can enter a water-soluble active additives, pH regulators. The resulting turbid solution is unstable over time at room temperature (20-23C).

Example 11.

The entire process is conducted under normal conditions, the temperature of 20-23°C. 13.3 g of PEG-8 Glyceryl of Isostearate and 6.7 g of PEG-20 Glyceryl of Isostearate, represent nonionic surfactants defined above, is mixed with heavy use of mixer until smooth. Then in the resulting homogeneous mixture was added 8 g Cetearyl of octanoate and 12 g of Cyclopentasiloxane. Again include a mixing device and high speed stirred to obtain a homogeneous mixture. In a separate container parallel to prepare a solution of polyols consisting 28,75 g of Water and 1.25 g of Butyleneglycol and 1.25 g of Dipropyleneglycol. The resulting solution of polyol added to the homogeneous mixture of surfactants, oil components under vigorous stirring. Intensively stirred for 10-15 minutes. After intensive stirring, add the remaining estimated amount of water for this composition. At this stage you can enter a water-soluble active additives, pH regulators. The resulting turbid solution is unstable over time at room temperature (20-23°C).

1. A method of obtaining a microemulsion cleaning the th cosmetic cutaneous application, comprising a mixture of nonionic surfactants, oil components until smooth and add water and polyols, wherein the pre-mix 40-60 wt.% water with polyols, add it to the mixture of nonionic surfactants, oil components, mix until smooth and enter the remaining amount of water, when this process is carried out with vigorous stirring at room temperature.

2. The method according to claim 1, characterized in that as neinogennye surfactants (nonionic surfactants) used PEG-8 Glyceryl of Isostearate, and/or PEG-20 Glyceryl of Isostearate, and/or PEG-8 Caprylic/Capric Triglycerides.

3. The method according to claim 1, characterized in that the polyols used butyleneglycol and/or dipropyleneglycol.

4. The method according to claim 1, characterized in that the oil component used cetyl ethylhexanoate, and/or Cetearyl octanoate, and/or Cyclopentasiloxane.

5. Cleansing cosmetic cutaneous application, obtained by the method according to claim 1.

6. Cleansing cosmetic skin application according to claim 5, characterized in that it contains, in wt.%:

Surface active substances (SAS)20-30
M is Kanye components 10-68
The polyols4-10
Water100

7. Cleaning microemulsion cosmetic skin application according to claim 6, characterized in that it further contains active additives, pH regulators.



 

Same patents:

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutics and represents a diagnostic technique for oral hygiene in an individual that implies sampling of a gingival crest fluid from the individual and analysing the sample for one or more metabolites.

EFFECT: periodontal disease or oral health is diagnosed in the individual on the basis of the detected metabolite.

7 cl, 1 ex, 5 tbl

FIELD: chemistry, cosmetology.

SUBSTANCE: invention discloses a mineral-containing base for decorative cosmetics, which includes natural zeolite powder, characterised by that it contains powder of an inorganic sunscreen additive, an inorganic pigment and mica mineral, wherein components of the base are in a defined ratio in wt %.

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4 cl, 5 ex

Leather cleaner // 2521302

FIELD: process engineering.

SUBSTANCE: invention relates to leather conditioner comprising a fibrous substrate and cleaning composition activated by dampening with water with subsequent mechanical effects that allow production of cleaning foam. It differs from known designs in that said substrate is composed by a pad based on cotton fibre braided by water jets of mass varying from 100 g/m2 to 300 g/m2. Note here that cleaning composition contains at least one surfactant in amount of 15-35 wt % with respect to total mass of glycerine and glycerine in amount of 55-75 wt %. Amount of water at substrate is 25% smaller than article mass. This article contains 0.1-1.2 g of active material of said composition per 1 g of said substrate. Note here that article strength in machine direction after its dampening is at least 10% higher than that before dampening.

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11 cl, 1 tbl, 3 dwg

FIELD: medicine, pharmaceutics.

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24 cl, 9 ex, 8 tbl, 2 dwg

FIELD: chemistry.

SUBSTANCE: group of inventions relates to precipitated materials from silicon dioxide for application as abrasive substances or thickening agents in preparations for tooth care, which are simultaneously efficient for closing dentinal tubules in order to reduce dentin sensitivity. The claimed precipitated material from silicon dioxide has an average size of particles from 1 to 5 microns and contains a metal adduct, present on at least a part of its surface for formation of a metal adduct-processed precipitated material from silicon dioxide, which demonstrates more than 10% reduction of zeta-potential in comparison with precipitated material from silicon dioxide of the same structure but without the metal adduct. Also claimed are: versions of tooth care preparation, containing the said precipitated material from silicon dioxide and a method of processing teeth of a mammal with application of such preparations.

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19 cl, 11 tbl, 10 ex, 6 dwg

FIELD: medicine, pharmaceutics.

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11 cl, 3 dwg, 1 tbl, 2 ex

FIELD: chemistry.

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26 cl, 2 tbl, 7 ex

FIELD: medicine, pharmaceutics.

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17 cl, 1 ex, 1 tbl

FIELD: chemistry.

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22 cl, 5 ex

FIELD: chemistry.

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13 cl, 7 dwg, 1 ex, 1 tbl

FIELD: cosmetology.

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4 cl, 4 ex

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FIELD: medicine.

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7 ex

FIELD: chemistry.

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1 tbl, 4 ex

FIELD: medicine.

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14 cl, 10 dwg, 6 ex

FIELD: medicine.

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13 tbl, 3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to the pharmaceutical industry, namely to an agent with an antidyslipidemic and analgesic effect. The method for preparing the phytocomplex with the antidyslipidemic and analgesic effect, involving: a) grinding peeled bergamot fruit to prepare an undegraded mixture, b) introducing pectinolytic enzymes into the mixture; c) reducing pulp content; d) inactivating the above enzymes added at the stage b), to prepare a degraded mixture; e) performing ultrafiltration of the degraded mixture through membranes isolating the substances having a molecular weight of over 30,000 Da, to prepare a transparent solution; f) introducing the transparent solution on a polyphenol absorption column; g) washing the polyphenol absorption column with water and increasing pH to prepare an aqueous polyphenol fraction; h) transmitting the aqueous polyphenol fraction to cationic resin to recover the phytocomplex in an aqueous phase; i) drying the phytocomplex in the aqueous phase. The phytocomplex in the aqueous phase with the antidyslipidemic and analgesic effect. The phytocomplex with the antidyslipidemic and analgesic effect. A pharmaceutical composition with the antidyslipidemic effect containing the phytocomplex, and pharmaceutically acceptable additives. A pharmaceutical composition with the analgesic effect containing the phytocomplex, and pharmaceutically acceptable additives.

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11 cl

FIELD: medicine, pharmaceutics.

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EFFECT: method enables effective recovery of the biologically active substances from roots and/or leaves of quick grass.

2 cl, 2 tbl, 2 ex

FIELD: medicine.

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2 ex

FIELD: medicine, pharmaceutics.

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EFFECT: method enables reducing labour input, reducing time and stages of the process, and decreasing the analyte loss.

1 dwg, 1 ex

FIELD: medicine.

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EFFECT: minimally painful keratoma removal.

3 ex

FIELD: medicine, oncology, amino acids.

SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.

EFFECT: valuable medicinal antitumor properties of preparation.

8 cl, 4 tbl, 2 dwg, 4 ex

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