Composite material for replacement of bone tissue
SUBSTANCE: invention relates to medicine, in particular to the field of composite materials for manufacturing endoprostheses. A composite material for replacement of bone tissue contains a porous matrix from crystalline carbon fibres with an inter-plane distance 3.58…3.62 angstrom with a content of fibres 20…80 of its total volume and a filling material, which contains crystalline carbon with an inter-plane distance 3.42…3.44 angstrom. In creation of the composite material for bone tissue replacement with an elasticity modulus, corresponding to the human bone tissue, the filling material contains obtained by Bakelite carbonisation amorphous carbon in the form of coke in an amount of 10…20% and obtained by methane decomposition crystalline carbon in an amount of 70-50% respectively of the total volume of the matrix pores.
EFFECT: composite material has the elasticity modulus, corresponding to the elasticity modulus of the human bone tissue.
The invention relates to medicine, more specifically to the field of composite materials for the manufacture of implants.
Known composite material for bone tissue substitution containing a porous matrix of fibers of crystalline carbon with the interplanar distance to 3.58...3,62 Angstrom with a fiber content of 20...80% of its total volume and the material of the filler having a crystalline carbon with the interplanar distance of 3.42...3.44 Angstrom - patent RU No. 2260402 C1, publ. 20.09.2005.
By its characteristics and the achieved result, this composite material closest to the proposed and adopted for the prototype.
Known composite material used for the manufacture of implants humans and animals and is characterized by the modulus of elasticity 14...28 GPA.
A disadvantage of the known composite material is excessively high module of elasticity, significantly higher than the actual modulus of human bone tissue.
The endoprosthesis made of a known material, more rigid in comparison with the bone tissue of a person and its interaction with the latter there is a continuous movement of the mating surfaces, which leads to a gradual loosening of the endoprosthesis and poor germination bone in his pores.
In addition, the pair of hard surfaces endop is otesa with healthy bone of a man causes a decrease of healthy bones and inhibits the creation of a new homogeneous bone.
The technical result of the invention is to provide a composite material for bone tissue substitution with a modulus of elasticity which best matches the elastic modulus of human bone tissue.
The mentioned technical result is achieved due to the fact that in the composite material for bone tissue substitution containing a porous matrix of fibers of crystalline carbon with the interplanar distance to 3.58...3,62 Angstrom with a fiber content of 20...80% of its total volume, and the material is a filler having a crystalline carbon with the interplanar distance of 3.42...3.44 Angstrom, according to the invention the material of the filler contains obtained by carbonizing a phenol-formaldehyde binder of amorphous carbon in the form of coke in the amount of 10...20% and obtained by the decomposition of the hydrocarbon gas crystalline carbon number of 70...50% respectively of the total the pores of the matrix.
The production of the composite material for bone tissue substitution are as follows. First of fibers of crystalline carbon with the interplanar distance to 3.58...3,62 Angstrom is made of a porous matrix with the content of fibrous material 20...80% of its volume, which is then impregnated with the estimated number of precursor amorphous carbon - phenol-formaldehyde binder, on the example of bakelite, and subjected to polymerization.
The obtained carbon billet is subjected to carbonization at a temperature of 1200 K for 3 hours, thus obtaining an amorphous carbon in the form of coke in the amount of 10...20% of the total pore volume of the matrix (which is an approximation of the modulus of elasticity of the composite material to the elastic modulus of human bone tissue).
After that make the pores are filled crystalline carbon with the interplanar distance of 3.42...3.44 Angstrom-70...50% respectively of the total volume of pores of the matrix by decomposition of a hydrocarbon gas such as methane, at temperatures of 1173 1273...(which ensures the compliance of the elastic modulus of the obtained composite material of human bone tissue).
The invention is confirmed by the test results presented in the table.
Why were produced samples of composite material for bone tissue substitution with different content of amorphous and crystalline carbon and conducted tests to determine the modulus of elasticity of the material of each sample.
Test results shows that the samples containing amorphous and crystalline carbon in the claimed range (experiments No. 3, 4, 5)are the moduli of elasticity as of human bone tissue, and samples containing amorphous and crystalline carbon outside of the stated limit is in (experiments No. 1, 2 and 6, 7, 8, 9)are the moduli of elasticity, which does not coincide with the bone tissue of the person.
Composite material for bone tissue substitution in comparison with the prototype is characterized by a modulus of elasticity equal to the elastic modulus of human bone tissue lying within 13,8...and 19.4 GPA.
|no experience||The content of amorphous carbon, %||The content of crystallic. carbon, %||The modulus of elasticity, GPA||Result|
Composite material for bone tissue substitution containing a porous matrix of fibers of crystalline carbon with the interplanar distance to 3.58...3,62 Angstrom with a fiber content of 20...80% of its total volume and the material of the filler having a crystalline carbon with the interplanar distance of 3.42...3.44 Angstrom, characterized in that the material-filler contains obtained by carbonization of bakelite amorphous carbon in the form of coke in the amount of 10...20% and obtained by the decomposition of methane crystalline carbon number of 70...50% respectively of the total volume of pores of the matrix.
SUBSTANCE: invention refers to medicine, namely to orthopaedic dentistry. A method for making an intraosseous dental implant involves sand-blast finish of an implant surface by alimunium oxide particles, plasma-based layer-by-layer deposition of a system of biocompatible coatings containing mixed titanium or titanium hydride or calcium hydroxyapatite powders onto an implant carrier. The first layer consists of titanium or titanium hydride of dispersity 3-5 mcm at spraying distance 70-80 mm and thickness 5-10 mcm. The second layer is titanium or titanium hydride of dispersity 50-100 mcm at spraying distance 100 mm and thickness 50-115 mcm. The third layer represents mixed titanium or titanium hydride of dispersity 40-70 mcm and calcium hydroxyapatite of dispersity 5-10 mcm in ratio 60-80 and 20-40 wt % respectively, at spraying distance 80 mm and layer thickness 15 -20 mcm. The forth layer consists of calcium hydroxyapatite of dispersity 40-70 mcm at spraying distance 70 mm and layer thickness 20-30 mcm. Thereafter, the multilayered system of the biocompatible coatings is covered by a metal film consisting of a ferric triad (iron, cobalt or nickel) of thickness 20-35 nm by magnetron sputtering. A carbon nanocoating of thickness up to 1 mcm is prepared thereon. The carbon nanocoating represents carbon nanotubes and carbon nanofibres of diameter 50-200 nm.
EFFECT: method provides making the implant coated so that to promote the active growth of bone tissue.
3 cl, 1 tbl, 4 dwg
SUBSTANCE: invention refers to a method for preparing a biocompatible nanostructured conducting composite. The method involves preparing an ultra-disperse suspension of carboxymethyl cellulose and carbon nanotubes with the mechanical system of carbon nanotube structuring wherein nanostructuring is enabled by exposing the suspension to laser light in a continuous mode at generation wave lengths 0.81÷0.97 mcm and light intensity 0.5÷5 Wt/cm2.
EFFECT: invention provides preparing the high-conductivity bio-composite.
1 tbl, 1 ex
SUBSTANCE: invention relates to medicine, in particular to orthopedics, and can be applied in production of endoprosthesis of human joints and other products, as well as in different fields of technology. Carbon-carbon compositional material (CCCM) with filler in form of carbon tissue layers has pyrocarbon matrix, which additionally contains boron. Components in its matrix are in the following ratio, wt % boron - (1-19); pyrocarbon - the remaining part. In addition, into CCCM filler layers of titanium mesh can be additionally introduced between carbon tissue layers.
EFFECT: by means of invention increase of physical and mechanical properties of carbon-carbon composition materials is achieved.
2 cl, 2 tbl, 3 ex
SUBSTANCE: invention relates to laser equipment used for the purposes of nanotechnologies, particularly, to the methods of nanostructurisation of bulk bio-compatible nanomaterials by laser radiation. Nanostructurisation of the aforesaid materials is performed by laser irradiation of colloidal water-protein solution of carbon nanotubes till evaporation of the solution liquid component.
EFFECT: varying the properties of produced materials in a wide range and remote irradiation provides for biological purity of products.
FIELD: medicine; maxillofacial surgery.
SUBSTANCE: coal-plastic composition for bone defects elimination includes carbonic material "ТГН-2М" and polyamide film 12/10. The novelty consists in additional introduction of titanium powder; the ingredients proportion being as follows, in wt %: carbonic tissue "ТГН-2М" 57.5-62.5, titanium powder 2.5-7.5, polyamide film 12/10 the rest. Titanium powder particles size is 20 to 50 mcm.
EFFECT: radiodensity and biocompatibility increase, toxicity and carcinogenicity lowering.
2 cl, 1 tbl
FIELD: medicine; maxillofacial surgery.
SUBSTANCE: coal-plastic composition for bone defects elimination includes carbonic material "ТГН-2М"and polyamide film 12/10. Silver powder is additionally introduced; the ingredients proportion being as follows, in wt %: carbonic tissue "ТГН-2М" 57.5-62.5, silver powder 2.5-7.5, polyamide film 12/10 the rest. Silver powder particles size is 20 to 50 mcm.
EFFECT: radiodensity and biocompatibility increase, toxicity and carcinogenicity lowering, gaining anti-inflammatory and antiseptic properties.
2 cl, 1 tbl, 3 ex
SUBSTANCE: composition of black-reinforced plastic for bone defect correction contains carbon-base material "ТГН"-2M and polyamide film 12/10. Additionally composition contains powdered titanium and silicon at following ratio of components, wt %: carbon-base material "ТГН"-2M 60-64.5, powdered titanium 1.25-3.75, powdered silicon 1.25-3.75, and polyamide film 12/10 - the rest. Particle size of powdered silicon and titanium is 20-50 mcm.
EFFECT: higher radiopacity and biocompatibility, reduced toxicity and carcinogenicity of material.
3 cl, 1 tbl, 3 ex
SUBSTANCE: composition of black-reinforced plastic for bone defect correction contains carbon-base material "ТГН"-2M and polyamide film 12/10. Additionally composition contains powdered silicon at following ratio of components wt %: carbon-base material "ТГН"-2M 57.5-62.5, powdered silicon 2.5-7.5, and polyamide film 12/10 - the rest. Particle size of powdered silicon is 20-50 mcm.
EFFECT: higher radiopacity and biocompatibility, reduced toxicity and carcinogenicity of material.
2 cl, 1 tbl, 3 ex
FIELD: medical engineering.
SUBSTANCE: method involves precipitating pyrocarbon layer on graphite substrate surface by carrying out carbonaceous gas from gas flow in flow reactor, separating pyrocarbon layer from the substrate and mechanically manufacturing cusp with paired supporting projections. Constant graphite substrate orientation is provided with relative to gas flow direction in the reactor during the whole pyrocarbon layer sedimentation process. The paired supporting projections are arranged in a way that their imaginary axis remains coinciding with carbonaceous gas flow direction when precipitating pyrocarbon layer. Graphite substrates are mainly shaped as plates placed into flow reactor along its lateral walls without spaces available between them. Six and more plates are placed into the reactor. The most convenient carbon compound for producing pyrocarbon by decomposition is methane. Propane and trichloroboron availability in gas flow is desirable. Additional inert carrier gas like nitrogen is available in the gas flow in addition to active ingredients. Pyrocarbon sedimentation and its final characteristics are controlled by varying nitrogen and active substances proportion in the gas flow.
EFFECT: high reliability of design.
3 cl, 2 dwg
SUBSTANCE: invention relates to composition materials used in making endoprosthesis and in using the composition material for replacement of osseous tissue. The composition material for replacement of osseous tissue comprises a porous matrix made of carbon fiber and carbon material - a filling agent filling pores of matrix partially and wherein the interplanar distance d002 in carbon material crystal is 3.58-3.62 Å, and the interplanar distance d002 in carbon crystal-a filling agent is 3.42-3.44 Å in the total amount of carbon fiber 20-80%. Invention provides enhancing strength and safety of junction of endoprosthesis material with osseous tissue due to creature of the composition material for replacement of osseous tissue with the elasticity modulus equal with the human and animals elasticity modulus in the range 14-28 hPa.
EFFECT: improved and valuable properties of material.
SUBSTANCE: implant for maxillary sinus perforation closure represents an outer cylinder wherein an internal cylinder is mounted. The outer cylinder is made of BT-5 grade titanium and has a mesh structure with the diameter corresponding to the diameter of a perforated alveolar socket. The inner cylinder is made of BT-5 grade titanium and has a monolithic structure and has an internal conical thread hole for the screw with a retaining ring, two spikes on the side surfaces and a platform with a thread hole in the upper part for screwing in up to the retaining ring. The inner cylinder is vertically dissected into two equal portions to the platform which can be drawn apart with the spikes penetrating into bone walls of the alveolar socket. The length of the inner cylinder makes 2/3 of the length of the outer cylinder.
EFFECT: reducing the extent of the oral tissue injury and the time for dental restoration.
2 cl, 3 dwg
SUBSTANCE: group of inventions refers to medicine, specifically dentistry, and is applicable for dental implantation. An osseous dental implant comprises the first and second osseous grafts. The first osseous graft is adjusted by the size and shape so that to fit a buccal surface of a periodontal alveolar surface about at least one tooth and to repair at least one portion of one or more periodontal bone defects. The second osseous graft is adjusted by the size and shape so that to fit a lingual/palatal surface of the periodontal alveolar surface about at least one tooth and to repair at least one additional portion of one periodontal bone defect. The above portion and additional portion together complementary close one or more periodontal bone defects. The group of inventions also involves the second version of the dental osseous implant and two versions for making them.
EFFECT: making the osseous graft adjusted by the size and shape to fit the surfaces of the periodontal alveolar surface for treating loss of tooth substance in the newly formed bone defect.
22 cl, 16 dwg
SUBSTANCE: calcaneal implant is presented in the form of a solid structure of a porous NiTi reinforced plate and consists of a horizontal platform and a vertical rod. The vertical rod is presented in the form of a parallelepiped and separates the horizontal platform on a posterior shoulder and an anterior shoulder. The posterior shoulder has a length less than that of the anterior shoulder, and a transverse through canal, which is connected with two holes perpendicular thereto. The anterior shoulder has a width and height decreasing to an end face step-like. The horizontal platform has grooves formed along its lateral areas, and a number of through holes arranged along the edges of the lower and upper plates. The through holes are inserted into the groove.
EFFECT: more effective rehabilitation and reduced length of treatment of the patients after the partial and total calcaneal resection by replacing the calcaneal or its defect using the porous NiTi implant.
2 ex, 9 dwg
SUBSTANCE: subtalar implant comprises a body in the form of a truncated cone threaded on an external surface and having a key hole along the axis. The body comprises three long slots equally spaced and dividing the body on three equal parts. The slots in the screwing off direction has platforms lowered by a height of a thread tooth, while teeth from the opposite side of the slot are rounded at a radius.
EFFECT: device provides more reliable fixation, prevents its migration from a subtalar sinus and provides the stable correction of the talocalcanean joint in the correct position.
SUBSTANCE: invention refers to medicine, namely to traumatology and biotechnology, and may be used for the biocompatible polymeric structure formation in bone tissues. That is provided by a puncture approach to a filled cavity in the bone tissues. That is followed by filling the cavity with a polymeric gel compound containing 55-97.7 wt % of the biocompatible polymer polylactide of a particle size of 50 to 100 mcm, 0.3-45 wt % of magnetic nanoparticles of ferric oxide of a particle size of 10 to 100 nm, the gelling agent maltodexrin in the amount of 0.5 to 50 wt % of the weight of mixed polymer and magnetic nanoparticles, as well as distilled water in the amount of 0.5 to 100 wt % of the weight of a dry mixture of the polymer, magnetic nanoparticles and gelling agent. A solid three-dimension structure is formed. That is accompanied with heating the compound throughout by exposing to an alternating magnetic field at frequency 500 kHz and amplitude 500 E for 3-5 minutes. Where appropriate slow down the process of heating the compound, it is additionally exposed to a direct magnetic field at amplitude 1000 E applied either to the whole formed volume, or locally depending on the problem to be solved.
EFFECT: method enables forming the biocompatible three-dimension structure in the specified cavity of the bone tissue with minimum surgical intervention.
SUBSTANCE: what is described is a method for making endosseous implants involving a plasma lamination of a biologically active coating on a metal base of the implant; titanium is sprayed remotely as the first and second layer, while the third layer is a mechanical mixture of titanium and hydroxyapatite powders; the fourth layer is formed on the basis of hydroxyapatite or aluminium oxide by mixing a boehmite powder of dispersity no more than 50 nm with hydroxyapatite or aluminium oxide powders in the amount of 5-20% of the boehmite powder of total substances; boehmite is taken in the form a suspension prepared by adding a surfactant dissolved in distilled water in the concentration of 0.25-5%, treated in an ultrasonic bath; then, the prepared suspension of boehmite and hydroxyapatite or aluminium oxide is treated in the ultrasonic bath, dried, tempered and milled.
EFFECT: endosseous implants have the high-strength biocompatible coating.
5 cl, 2 dwg
FIELD: process engineering.
SUBSTANCE: invention relates to medicine. Proposed method can be used in stomatology and orthopedics for production of medical materials stimulating recovery of bone tissue defects, for making dental stopping and dental pastes. It comprises preparation of mix containing compounds of calcium, phosphorus, silicon and sodium, impregnation of bioinertial incombustible porous matrix with made mix, matrix is composed of ceramics from aluminium or zirconium oxides followed by calcination. Note here that silicon compound represents tetraethoxysilane. Note also that phosphoric acid ether is used as phosphorus compound. Calcium and sodium compounds are represented by their carboxylates in polar organic solvent. This method includes making the thin layers on more strong bioinertial porous ceramics. Note also that said process involves no special complicated equipment and expensive reagents.
EFFECT: production of glass ceramics directly from solution omitting sol preparation stage, simplified and accelerated process.
7 cl, 5 ex
SUBSTANCE: invention refers to medicine. What is described is Brushite water cement for bone tissue repair containing α-tricalcium phosphate powder and a tempering fluid representing a magnesium phosphate solution in phosphoric acid, wherein the cement powder contains calcium carbonate granules 50-100 mcm in size in the following proportions: α-tricalcium phosphate - 90-95 wt %, calcium carbonate - 5-10 wt %. What is described is Brushite water cement for bone tissue repair containing α-tricalcium phosphate powder and a tempering fluid representing a magnesium phosphate solution in phosphoric acid, wherein the cement powder contains calcium carbonate granules 50-100 mcm in size in the following proportions: α-tricalcium phosphate - 90-95 wt %, carbonated hydroxyapatite - 5-10 wt %.
EFFECT: calcium phosphate cements are characterised by a combination of an ability to reaction hardening, an ability to be shaped, biocompatibility, the absence of toxic side effects, as well as a potential to be replaced by the newly formed bone tissue.
2 cl, 4 ex
SUBSTANCE: invention refers to medicine. A prosthesis, particularly for at least a partial replacement of a long tubular bone comprises an insertion joint for connection of a pin with the other prosthesis part. The insertion joint is formed by an axial projection and a pocket. The pin comprises a transverse drill hole, while the other part accommodates a projecting non-pivotal rod wherein there is a lateral axis. The above lateral axis is engaged behind the projection and has a central axis which has an axial displacement (d) with respect to the axis of the transverse drill hole. A clamping element with its inserted end being engaged with the transverse drill hole is introduced into the lateral axis.
EFFECT: when using the insertion joint with the unitised prosthesis connection, the invention provides such holding of the insertion joint to enable the effort generation under all circumstances, including unfavourable intraoperative conditions, such as an inadequate approach to the operation site.
11 cl, 6 dwg
SUBSTANCE: invention refers to a device and method of treating bacterial diseases. The device comprises a trocar, a perforator, a pusher, a silver electrode, a temporary electrode, a needle made of a biocompatible material having a negative electric potential to silver, one or more second electrodes made of the same material as the needle, an external DC voltage, and a conductivity metre. The method using the device involves the stages of drilling a hole in an infected bone or within an infected area, implanting the small silver electrode therein, placing the temporary electrode in the hole above the silver electrode in close contact therewith, establishing an electrical connection of the temporary electrode to a first clamp of the conductivity metre, establishing an electrical connection of the needle to a second clamp of the conductivity metre, touching the skin surface with the needle in a point close to the hole and measuring the path conductivity from the silver electrode to the needle, restarting a touch pitch in various skin locations as long as the path having the highest electrical conductivity is found, and marking the corresponding needle location, disconnecting the conductivity metre from the temporary electrode and removing the conductivity metre and the needle, introducing the second electrode subcutaneously in the marked location, establishing an electrical connection of one clamp of the DC voltage to the temporary electrode, and its second clamp - to the second electrode, passing the current of less than 0.5 mA for 5-120 s between the silver electrode and the second electrode, disconnecting the second clamp of the DC voltage from the second electrode, removing the temporary electrode and the DC voltage.
EFFECT: using the invention provides a prolonged antibacterial effect which has a preventive effect and after completion of the therapeutic course of infection.
18 cl, 13 dwg
FIELD: medical engineering.
SUBSTANCE: device has periosteal part, intraosseous pedicle and a member manufactured from porous material. The pedicle is tube having longitudinally split and outward bent leaflets manufactured from material possessing shape memory properties. The porous member is coaxially arranged in the tube.
EFFECT: reliable primary self-locking features and secondary fixation features in remote period.
2 cl, 3 dwg