Method of treatment of acute hepatosis in cats

FIELD: veterinary medicine.

SUBSTANCE: method comprises administering to the animals in the supine position, in addition to the general course of treatment during 5-7 days of 0.5% novocaine solution, depending on the age at a dose of 1.0-2.0 ml per kg of live body weight with adding 1.0 g of cefazolin in the region of the round ligament of the liver, the administration of novocaine solution with cefazolin. The injections are carried out in a cat in the supine position, at the point at 4.8-5.2 cm cranial to the umbilicus along the sagittal line of the abdomen in the dorsal direction. The puncture is made with the needle to the depth of 0.9-1.1 cm to the feeling of characteristic falling of the needle under the aponeurosis of the rectus abdominis muscle. The preparation solution is administered under pressure.

EFFECT: method is simple to use and highly effective for the treatment of acute hepatosis in cats.

2 tbl, 1 ex

 

The invention relates to veterinary medicine small animals, in particular for veterinary therapy, and can be used for the treatment of acute hepatosis in cats.

There are several different methods of treatment of laboratory cats. Basically, the treatment aims at the detoxification of the body and strengthening of the regenerative processes in the liver, leading to the restoration of its anatomical structure and functional activity. Apply a decoction of corn stigmas, immortelle, chamomile and other herbs. For normalization of liver function prescribed intravenous solutions of glucose, vitamin C, hexamethylenetetramine. Also used drugs (Essentiale, siripur, LIV-52 and others).

There is a method of treatment of laboratory cats, consisting in the use of the drug "Gepatit". In the preparation includes: phospholipids, methionine, L-ornithine, extract, milk Thistle and grass Immortelle. "Gepatit" is given orally in a dose of 0.3 ml/kg of body weight cats for 30 minutes before feeding. The duration of treatment cats using hepatomata - 30 days (per day used 3 times). The disadvantages of the method include a long course of treatment [1].

There is a method of treatment of laboratory cats with use of the drug "Heptral, which is recommended to be administered intravenously or intramuscularly at a dose of 100-200 mg (per day). Cf is to treatment is 2-3 weeks. The disadvantage of this method is the high cost of the drug and long term treatment [2].

There is a method of treatment of laboratory cats, including pathogenic therapy and the use of the drug "Essentiale Forte H" in injectable form. The drug is administered intravenously in doses of 0.05-0.1 ml per 1 kg of live weight, the treatment is 5-7 days [3, 4]. However, the effectiveness of this method of treatment for acute steatosis is not high enough.

The aim of the invention is to increase the efficiency of treatment of acute hepatosis in cats. This is achieved by the fact that the conventional treatment for steatosis in cats additionally include a single daily administration within 5-7 days 0.5% solution of novocaine with 1.0 g of Cefazolin dose of 1.0-2.0 ml/kg of body weight in the round ligament of the liver. Introduction solution of novocaine with Cefazolin, pre-warmed in a water bath to a temperature 38,0-38,5°C, hold the cat on his back at a point 4.8-5.2 cm more cranial to the umbilicus in the midline of the abdomen in dorsal direction, perpendicular to the anterior abdominal wall make the puncture needle of the average diameter to a depth of 0.9-1.1 cm to the feeling characteristic of dropping the needle under the aponeurosis of the rectus abdominis muscle, then the angle of advancement of the needle is changed to 43-47° in the direction of the liver and under the pressure of the injected drug solution. P is overca the proposed method of treatment of acute hepatosis cats on compliance with the conditions of patentability "novelty" shows what the prior art does not know such technical solutions similar to the claimed invention, including drug infusion in the region of the round ligament of the liver in acute hepatosis in cats.

The proposed method for the treatment of acute hepatosis in cats involves an inventive step, as for the specialist it is not obvious from the prior art. The introduction of a 0.5% solution of novocaine with Cefazolin in the region of the round ligament of the liver in cats when hepatosis so far not been used by specialists in veterinary practice. Our anatomical studies have shown that the round ligament of the liver (umbilical vein) cats over the age of 30 days completes the process of natural anatomical obliteration and 6 months is a connective tissue strand, surrounded by fatty tissue, isolated from the abdominal cavity on all sides parietal peritoneum. This morphological feature when infiltration in the region of the round ligament of the liver contributes to the directed distribution of infusion solution, in the direction of glassonby capsule of the liver, which are approved by the technique of phase-contrast - 30% solution of Urografin.

Novocaine has a complex action on the peripheral nervous system, which includes elements of inhibition and stimulation resulting in improvement of its trophic function. In addition, there is increased blood flow, which in turn contributes to the relief of muscle spasm. Local announcement of the antibiotic Cefazolin suppresses the infection and prevents reproduction of pathogenic microflora, as a function of the reticuloendothelial system when steatosis was reduced.

Novocaine from generating pulses at the end of the sensitive nerves and holding their nerve fibers, reduces the excitability of peripheral cholinergic systems. These factors lead to a rapid decrease of swelling of the liver parenchyma, reduce pain, prevent the development of pathogenic microflora, which contributes to the elimination of symptoms of General intoxication of the organism and to normalize the physiological functions of the body.

The claimed technical solution meets the condition of "industrial applicability"as a method of treatment of acute hepatosis in cats can be used in the practice of veterinary medicine.

The example run. To examine the efficacy of a treatment for acute hepatosis cats on the basis of the veterinary clinic, Dog training Center - Tair (, Zlatoust, Chelyabinsk region) experiment was carried out in 2012-2013. For experiment 20 cats with the observed diagnosis of steatosis were divided into 2 groups of 10 animals each, according to the principle of the steam-analogues. Ucayali the history, gender, age, disease duration, severity of the General condition of the pathology, the severity of clinical symptoms at the time of admission to the clinic.

Animals of the first group was treated by a commonly known method, including complex pathogenetic therapy. This regimen consisted of:

1. Supportive therapy - intravenous infusion:

a). Salt solution (saline, ringer's solution at a rate of 10-20 ml/kg, depending on the degree of dehydration);

b). Nutrient solutions (glucose 5%, Dualit based 6-20 ml/kg depending on the degree of malnutrition).

2. Vitamin therapy (catosal, the rate of 0.5 to 2.5 ml per animal, depending on the individual state, ascorbic acid 0.1 ml).

3. Hepatoprotective therapy (Essentiale Forte H rate of 0.05-0.1 ml / kg of body weight).

4. Antibiotic therapy (amoxicillin is known to be (clamoxyl LA) at a rate of 1 ml per 10 kg of body weight).

5. Antiemetic drugs (if necessary reglan rate of 0.05 ml/kg).

Cats of the second group treatment was supplemented with a daily injection of a 0.5% solution of novocaine at a dose of 1.0 ml/kg body weight with the addition of 1.0 g of Cefazolin, in the region of the round ligament of the liver, within 5-7 days.

The solution was prepared as follows: into a vial containing 1 g of Cefazolin, was added 5 ml of 0.5% solution of novocaine, D. who was idalis complete dissolution of crystals of antibiotic. The calculation of the dose of 0.5% solution of novocaine with dissolved 1 g of Cefazolin was performed: for cats with body weight 1-3 kg dose injection was 2-6 ml, animal with a live weight of 4-8 kg - 6-10 ml. Cats with body weight of more than 8 kg, you must enter a 10 ml Volume of 0.5% solution of novocaine with Cefazolin more than 10 ml type is not recommended because of possible sharp drop in blood pressure and collapse. The dose of 1.0-2.0 ml/kg of body weight is optimal.

Technique of introducing a 0.5% solution of novocaine with Cefazolin consisted of the following stages. Initially, the solution was pre-heated on a water bath until 38-38,5°C. Then the cat on his back on the middle line of the abdomen 5.0 cm above the navel, spent the puncture needle in the dorsal direction to a depth of 1.0 cm to the feeling characteristic of dropping the needle under the aponeurosis of the rectus abdominis muscle. Then using a constant finger pressure on the plunger of the syringe were injected with the drug solution.

For sick animals clinical observation. To assess health took blood samples for laboratory tests on the day of receipt, on the sixth and twelfth days from the start of therapy.

When the clinical observation drew attention to the General condition of the animals, change of appetite, vomiting, change in fluid intake, status is e skin and mucous membranes (yellowness), conducted macroscopic assessment of physiological excrement.

The improvement of the General condition of the animals was ascertained by the reduction or disappearance of icteric staining of the skin and visible mucous membranes, dyspeptic phenomena, the reduction of pain on palpation of the liver, the normalization of the General clinical-physiological state cats, as well as the emergence of positive dynamics in biochemical analysis of blood serum samples.

The recovery is considered full restoration of all physiological functions of organs and systems of the body with regard to laboratory data.

The analysis of the clinical results of treatment of cats the first group showed the following: through the days that have passed since the beginning of the complex conservative therapy, the improvement of the General condition of the animals was not observed, one cat died, the two cats came deterioration of the clinical condition.

On the second day, improvement was observed in three animals, one cat died. On the third day, was seen the following picture: the improvement occurred in two cats, two animals were no positive changes, one animal died.

On the fourth day changes the dynamics of the disease was not observed in any other cats. On the fifth day of conservative treatment, the remaining 7 cats showed a clinical improvement: alive is fair became more active, all disappeared vomiting, decreased daily fluid intake, appetite. Yellowness of the skin and visible mucous continued to persist. Dark urine and agalychnis chair remained.

6-8 day special dynamics of clinical signs were not observed. 9-10 day yellowness of the skin and mucous membranes in all tested cats first group decreased. Urine became lighter, the chair took a normal color.

On 11-12 day, clinical recovery was observed in two cats, five slight yellowness of the skin and mucous membranes. To 15 days, two cats recovered. For 18 days, recovery was observed in the remaining three animals.

Analysis of clinical findings in the treatment of cats second experimental group revealed the following: for the third day, having passed since the beginning of the treatment proposed method of treatment, including conventional therapeutic measures, supplemented by drug infiltration of the round ligament of the liver, improving the General condition occurred in nine animals. They became more active, appetite disappeared thirst at one cat. Specific dynamics of clinical symptoms were not observed.

By the fifth day, the General condition improved in all ten animals, five cats significantly decreased interesest (yellowness) of the visible mucous membranes, has brightened the urine, cal took the usual natural color.

For 7-8 days, three cats recovered, the remaining seven animals yellowness decreased. To 10-12 days, all tested animals a second experimental groups were recovered.

Clinical data of the comparative analysis of results of treatment of cats first and second (experimental) groups with a diagnosis of acute steatosis presented in table No. 1.

Table 1. Comparison of clinical results of treatment in cats
GroupObservation days
1-4 day observation5-8 night surveillance9-12 day observationmore 12 days of observation
The first group5 cats - improvement, 3 cats died, 2 cats - without speakers7 cats were observed clinical improvementthe 2 cats were observed recovery5 cats recovered
The second group9 cats - improvement, 1 cat - unchanged3 cats in what was Zdorovie, 7 cats - observed clinical improvementthe remaining cats recoveredanimal studies have not left

From an analysis of the table shows that in animals treated with additional infusions in the region of the round ligament of the liver, there was no mortality, compared with three cases in the first group. Significantly faster improvement of the General condition of the animals and their recovery: 12 days passed from the beginning of therapy, all cats from the second group recovered, whereas the recovery of the animals of the first group was delayed until 18 days.

These laboratory methods for monitoring sick animals in the dynamics presented in table No. 2.

From the data presented in table No. 2, it is evident that by the sixth day of observation, the cat of the second group of indicators were normalized total protein, glucose, creatinine, lactate dehydrogenase, cholinesterase, indicating a more rapid reparative processes in the liver of these animals. Normalization of parameters of cholinesterase, erythrocyte sedimentation rate, C-reactive protein in animals of the second experimental group indicate a weakening of the inflammatory process in the liver to this day in comparison with indicators of the cats from the first experimental group. By the 12th day of disease on the background of therapy in alive is the shaft of the second experimental group was normalized all the blood counts, and cats first experimental group indicators such as hemoglobin, ESR, total protein, bilirubin, alkaline phosphatase, AST, Alt, cholinesterase remained pathologically altered. Comparative evaluation of the presented data suggests that the functional capacity of the liver in cats the second experimental group recovered significantly faster than animals receiving conventional therapy for acute hepatosis.

Table 2. Data hematological and biochemical studies of blood serum of cats
Metric unitsNORMA1 dayday 6day 12
1 gr.2 gr.1 gr.2 gr.1 gr.2 gr.
1. Hemoglobin, g/l80,0-150,070,065,068,964,570,2±3,2786,6
2. ESR, mm/h0,0 is 13.025,019,018,915,016,8±1,1510,0
3. Total protein, g/l54,0-77,045,050,0to 47.271,0±4,2450,063,3
4. Glucose, mol/l3,3-6,33,22,9±0,893,05,83,04,8
5. Creatinine, mol/l70,0-165,065,370,065,880,0±4,4966,884,0
6. Urea, mmol/l5,4-12,15,8a 4.96,18,95,010,0±0,15
7. Bilirubin, mol/l3,0-12,080,6101,975,921,4±2,3530,213,8
8. Gamma - glutamyltransferase, IU/l1,0-10,07,9±1,166,26,98,4±0,136,99,1±0,15
9. Alkaline phosphatase, IU/l39,0-55,060,055,651,3±3,2955,2to 58.154,0
10. ACT, IU/l9,0-29,0of 58.962,750,138,932,025,0
11. ALT,IU/l19,0-79,0301,2±12,1330,8203,4±11,3108,1120,062,0
12. LDH, IU/l55,0-155,0the amount of 203.9230,1180,8160,9165,0±5,25156,0
13.
Cholinesterase, u/l
2000,01100,01400,01200,0±62,382050,0±147,81900,02100,0
14. C-reactive protein, mg/l0,08,0to 12.08,0±1,33,02,50,0
Authentically p<0,05

This manipulation is contraindicated in cats that have not reached the age of 6 months who have not yet completed natural morphogenesis of the round ligament of the liver.

We have developed a method for the treatment of acute hepatosis in cats is an effective, low-cost and simple from the point of view of its technical application. This manipulation allows for local transport of therapeutic substances to the affected organ, thus reducing the cost of drug substances is TBA for additional absorption in the organs of the body, that provides clinical recovery in a short time in the tested animals. A method of treating acute hepatosis in cats recommended widely used in veterinary practice.

The list of references

1. Klimov PV Efficiency new hepatoprotective drug "Gepatit" in the treatment of laboratory dogs and cats / PV Klimov A. Fedosov // Questions of normative-legal regulation in veterinary medicine. - 2011. No. 2. - P.42-44.

2. Gary D. Norsworthy the Feline Patient. Fourth Edition. WileyBlackwell. A. John Willey and Sons, Inc., Publication, 2010. - 1052 p.

3. Clinical gastroenterology animals / I.I. Kalyuzhny, N Barinov, FI fedyk and others; Ed. by I.I. Kalyuzhny. - M.: Colossus, 2010. - 568 S.

4. Handbook of diseases of dogs and cats / Series "veterinary science and animal husbandry". - Rostov n/A.: "Phoenix", 2000. - 352 S.

A method of treating acute hepatosis in cats, including complex pathogenetic therapy, characterized in that the animals in the supine in addition to the General course of treatment for 5-7 days is injected 0.5% solution of novocaine, depending on age at a dose of 1.0-2.0 ml per kg of body weight with the addition of 1.0 g of Cefazolin in the region of the round ligament of the liver, the introduction of a solution of novocaine with Cefazolin hold the cat on his back, at the point 4.8-5.2 cm more cranial to the umbilicus on the sagittal line of the abdomen in dorsal direction is the situation, puncture doing needle to a depth of 0.9-1.1 cm to the feeling characteristic of dropping the needle under the aponeurosis of the rectus abdominis muscle and under the pressure of the injected drug solution.



 

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3 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: claimed invention relates to chemical and pharmaceutical industry and deals with composition containing ceftriaxone (usually as sodium ceftriaxone) and sulbactam (usually as sodium sulbactam), which additionally includes gelating preparation of aminocarboxylic acid, for instance ethylenediaminetetraacetic acid (EDTA) or its pharmaceutically acceptable salt, for prevention of beta-lactamase-mediated resistance to antibiotics, intended for injection acceptable for its pharmaceutical application. Said compositions proved useful for intramuscular and intravenous introduction as antibiotics for inpatients with serious infections. It has been found that claimed pharmaceutical compositions usually increase resistance to formation of solid particles in solutions for parenteral introduction. Composition can be made in form, which is preserved in hermetically closed container and is to be restored before application. In addition, invention relates to method of said compositions manufacturing. Claimed is method of treating patient with state or disturbance, in which treatment with application of sodium ceftriaxone and/or sodium subactam is indicated.

EFFECT: composition possesses high stability during storage and does not form solid particles when diluted.

10 cl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to surgery and intensive therapy, and can be used in treating endotoxicoses caused by septic conditions. That is ensured by removal of a destruction area to be thereafter sanitised and drained. It is followed with lymphostimulating therapy by introduction of 0.25% Novocaine 60 ml with dissolved 0.1 g of Lydase and 1.0 ml of Pentoxifylline into the interspinous spaces in number of 1-3 injections. Further, discrete plasmapheresis in amount 400 ml for severe patients and 800 ml in moderate patients is applied in number of 1-8 procedures. The lymphostimulating therapy is alternated every second day with lymphotropic extracorporal pharmacoimmunotherapy with using a medicated mixture prepared by incubation of 40-60 ml of the patient's plasma with received plasma of the patient with Roncoleukin in dosage 500-1 million UN and Cefabol in dosage 1 g for 45 min at 37°C. In peritonitis and peritoneal sepsis, the medicated mixture is introduced in the bolus form in the retroperitoneal fat. The destructive processes in the pleural cavity require introduction of said mixture in the axillary cavity.

EFFECT: method provides endotoxin weakening in the bloodstream, intertissue spaces and cavities due to combined multidirectional local and system effect on the lymphoid system.

3 cl, 8 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely to combustiology, intensive and efferent therapy and can be used for treatment of children with a serious thermal trauma. For this purpose anticoagulant therapy is performed to patients for maintenance of hypocoagulation and level of molecules of average mass (AMM) at a wavelength of 254 nanometres are defined in a blood plasma. Treatment is performed at its value from 0.31 to 0.39 standard units, provided that accumulation of AMM prevails in plasma and on erythrocytes, or, at AMM level more than 0.39 standard units, and at AMM accumulation on erythrocytes, in plasma and urine. Infusion of crystalloid solutions in volume of coming hemoexfusion is preliminary performed. Then procedure of discrete centrifugal plasma depletion by unitary hemoexfusion in volume of 10-12% of volume of circulating blood, its gravitational separation and plasma excision is performed. After that 2 ml of the 1% ATP solution and an antibiotic from a number of cephalosporins of III generation in the higher single dose for children in are consistently entered into the received autocell mass.

EFFECT: working out of a way which allows preventing possible complications at treatment of children with the given pathology at the expense of a cryoplasm transfusion exception and other albuminous preparations and also to lower level of an endogenous intoxication, to simplify procedure of extracorporal haemocorrection at conservation of high degree of effect of detoxicating.

2 tbl, 2 ex

FIELD: chemistry, pharmacology.

SUBSTANCE: pharmacological composition for preparing drug forms in form of powder, solution or bandage consists of biocompatible film-generating polymer polyvinylpyrrolidone (Mm 20000), iodine and Novocain, taken in quantities, given in the invention formula. Pharmaceutical composition is intended for processing wound surface and treatment of burns. Composition possesses antiseptic, local anesthetic and wound-healing action.

EFFECT: water-soluble form of medication possesses high anti-burn activity, low cost and long storage term.

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