Method of treating periodontitis

FIELD: medicine.

SUBSTANCE: method of treating periodontitis involves dental deposit removal, dental polishing, curettage of gingival pockets, functional dental grinding and photodynamic therapy with using a photosensitiser with performing a session of photodynamic therapy using 1% aqueous toluidine blue as a photosensitiser; for this purpose, a retraction cord is placed into 1% aqueous toluidine blue until immersed completely; an exposition time in the solution makes 7-10 minutes; thereafter, the retraction cord kept in 1% aqueous methylene blue is inserted onto a gum pre-isolated from saliva in the gingival pockets completely within an involved group of teeth for 5-7 min and removed then; further, the gingival pockets treated with the photosensitiser are exposed to a laser light.

EFFECT: possibility to avoid complications related to recurrent photodynamic procedures and occurred when using the gel and installation photosensitisers, enables maintaining the concentration of the drug introduced into the gingival pocket immediately, and higher effect of the photodynamic therapy on microbial flora of periodontal pocket biofilm.

2 ex

 

The present invention relates to medicine, in particular to the dentist, and can be used in the treatment of various forms of periodontitis.

Today periodontitis is one of the most common complaints of patients in dental practice. According to the Ministry of Health of the Russian Federation, more than half of the adult population and about one-third of children in our country suffer from inflammatory periodontal.

The main reason for the emergence and development of periodontitis is insufficient oral hygiene, irregular and insufficient cleaning of the teeth by brushing and flossing. The reasons also include hereditary factors, the rapid formation of Tartar, malocclusion and incorrect installation of crowns.

The initial stage of periodontal disease is provoked by the accumulation on the surface of the plaque - nutrient medium for pathogenic microbes. As a result, the gap between the tooth and the gum pocket is formed, it expands, penetrates deep down to the bone. It continues to evolve, causing further development of diseases and pathogens. The disease is accompanied by bleeding, severe pain in the gums, heavy breath. If untreated broken tooth fixation in the periodontium and, as a consequence, observed at the rata of a tooth.

Comprehensive treatment shown in this pathology includes many different components: professional oral hygiene, surgical techniques, drug therapy. Traditional methods of treating periodontal disease also include antibiotic therapy, ultrasonic treatment to cleanse the teeth, ozone therapy. More than 90% of cases, treatment is limited to the removal of dental plaque manual or ultrasonic instruments. However, this treatment does not allow you to achieve long-term stabilization process.

As the main triggering factor in the development of periodontal disease is pathogenic microflora, it is obvious that the main method of treatment is its destruction. Today, there are many ways to neutralize it, the leading of which is conducting photodynamic therapy using photosensitizers.

Photodynamic therapy (PDT) is a part of phototherapy in which to achieve therapeutic effect requires light of a certain wavelength, required drug, photosensitizer and oxygen.

The photosensitizer is a key element in the procedures PDT. A fundamental prerequisite for optimal response to photosensitization is the ability of cells (tissues)target store and with the collective to keep the photosensitizing compound. With the capture of photosensitizer, light energy transfer and transformation of light energy into chemical reaction in the presence of molecular oxygen leads to the formation of singlestage oxygen (1About2) or superoxide (O2-), which has a direct and indirect cytotoxic effect.

Used in the clinic drugs have a range of photodynamic treatment with highs in the field 620-690 nm. It is known that the maximum permeability of fabrics is in the far red and near infrared region 750-1500 nm. Currently being directed search of such photosensitizers among the derivatives of chlorin, bacteriochlorin, purpurin, benzoporphyrin, texaphyrins, tiopourinol, Naftali and phthalocyanines. Particular interest are the photosensitizers, which are able not only to quickly accumulate, but has a high rate of excretion.

Ideal photosensitizer should meet the criteria, which were formulated at the end of the last century, but it has not lost its relevance to the present. These include:

1) Low or zero dark toxicity;

2) High selectivity of accumulation in microbial and pathological tissues and rapid elimination from the body after PDT;

3) FS must have a permanent structure and can be pre is respectfully simple substance;

4) it is Desirable that FS had a high triplet quantum yield and efficient energy transfer to generate singlestage oxygen;

5), the Maximum absorption should occur in the red region of the spectrum, where the tissue is more transparent to light used(1, 2, 3,).

Despite the fact that the ideal FS is not yet established, however, these criteria provide General guidelines for comparison and further research. In our paper we use the photosensitizer toluidine blue as the most satisfying above criteria in relation to the treatment of periodontitis.

The prior art method of disinfection of wounds and lesions in the oral cavity, comprising applying an aqueous solution of photosensitizing compounds, in particular toluidine blue by local installations, with consequent impacts on the area damaged by laser irradiation so as to destroy microbes (US 5611793, 1997-03-18).

The main disadvantage of this method is the use of a photosensitizer in the form of installations, which does not allow to create effective for killing microorganisms concentration of photosensitizer (according to our data, the required concentration will be achieved by exposure of the photosensitizer in the oral cavity for at least 5-7 minutes) and, as a consequence the vié, does not allow you to destroy all pathogens, resulting in repeated sessions.

The closest technical solution is a method of treatment of inflammatory periodontal disease by photodynamic therapy using photosensitize - toluidine-blue gel on the basis of (Burgansky VG, the Possibility of using laser technology for the treatment and prevention of periodontal and surgical dental reception, Modern dentistry, 5/2009, S. 64-68).

The main disadvantage of this method is the use of photosense in the form of a gel that insufficient washing reduces (and it will always be because of periodontal pockets it is poorly washed) the efficiency of passage of the laser beam at 95% and, as a consequence, it is not possible to destroy all pathogens, resulting in repeated sessions.

The task of developing technical solutions is improving the efficiency of the method of treatment of periodontitis using photodynamic therapy.

The technical result is achieved due to the use of retraction threads, soaked in 1% toluidine blue in complex treatment of periodontal diseases, which allows you to:

1. To simplify the PDT photosensitizer.

2. To avoid complications associated with repeated treatments, PDT, issues when using photosensitizers as a gel base, and entered by installations.

3. To keep the concentration of an administered drug.

4. To enter the drug directly into the periodontal pocket.

5. To reduce the time to reach the value of the normalized fluorescence, which helps to reduce the duration of procedures PDT.

6. To increase the efficiency of the photodynamic effects on microbial biofilm flora of periodontal pockets.

The method consists in the following. After establishing a proper diagnosis of the patient was conducted professional hygiene of the oral cavity by means of an ultrasonic device, curets of Langer, polishing brushes and pastes. Was carried out in removing dental plaque in combination with curettage of periodontal pockets was Conducted functional electoral presledovanie teeth. Also given recommendations and implemented training individual oral hygiene with the mandatory introduction in the everyday care of personal hygiene.

On the next visit the patient held a session of photodynamic therapy with 1% toluidine blue as a photosensitizer in the area of the affected teeth.

Pre-retraction thread was placed in a 1% aqueous solution of toluidine blue to complete the submersible is tion. The exposure time of the yarn in the solution 7-10 minutes. The thread was removed from the solution, allowed to drain the excess, cut to the required length.

On a previously isolated from the saliva of the gums, the periodontal pockets in the area of the affected teeth was introduced retraction thread, pre-soaked in an aqueous solution of 1% toluidine blue, on the depth of your pockets. The thread remained in the pockets for 5-7 minutes Then the thread was deleted and conducted impact on treated areas gums laser radiation from a diode laser apparatus ALOG-01 series "Grenades" with output power of 0.4 watts with a wavelength of 689 nm in continuous mode. The energy density was 100 j/cm2. The exposure time of the laser radiation to the area of impact was 4-7 minutes.

In our work we used as a photosensitizer 1% aqueous solution of toluidine blue. Toluidine blue (toluidin blau) - main casinoby dye used in histological technique for staining nervous tissue, detection of cell nuclei and basophilic structures, as well as metachromatic substances. It is a dark-green powder. Easily soluble in water with a blue-purple color. The industrial drug available in powder form, Packed in vials of 1, For the preparation of 1% aqueous solution it is necessary to make 1 g of toluidine blue is in 99 ml of water, dissolve in water at low heat, after which the solution should be filtered through cheesecloth. The resulting solution is ready to use.

As retraction of the thread we used, for example, GIGNGI - CANCER Z - TWIIST - covered tissue retraction thread, made from 100% cotton. You can also use untreated cotton retractive yarn company Soft-Twist or Gingi-Pak.

To clarify accumulation maximum concentration of toluidine blue in the gum introduced by the retractive yarn and optimal solution concentration of photosensitizer, we previously conducted a study of local fluorescence diagnostics in the tissue of the gums.

Fluorescence diagnostics allows scanning spots of the exciting laser radiation on the surface of the fabric to determine fototermoakystika removal of the photosensitizer from the pathological tissue with the aim of optimising the photodynamic treatment and monitoring during PDT.

When using a laser excitation source in the red region of the spectrum with the help of the device "Range"Cluster" measured range of exogenous fluorescence of tissue and monitored values of the normalized fluorescence (FN) tissue.

In normal gingival mucosa's fluorescent extremely weak (FN 0.1 to 0.4, the Lin - wave 590-640 nm), likely due to pathogenic microorganisms that are present in the microbial plaque, which is able to produce proto - and coproporphyrin.

Conducting fluorescence diagnosis with periodontal disease showed that in catarrhal gingivitis value of the normalized fluorescence (FN) averaged - 0,61±0,001; mild periodontitis - 0,91±0,003; periodontitis moderate - 1,19±0,003

According to the fluorescent diagnosis was established that the value of the normalized fluorescence (FN) after application of the drug with retraction of the thread (toluidine blue 1%) periodontitis were highest for 7 min, after which its value has stabilized and has not been changed. The maximum level was noted at 7 min after application of the photosensitizer in the periodontal pocket.

Thus, it was found that the maximum fluorescence of the photosensitizer in the tissue of the gums for inflammation in the periodontal occurs within 5-7 minutes after it is made and not subsequently changed, indicating that the maximum saturation of the gum tissue preparation. The optimal concentration corresponded to a 1% solution, because a large concentration did not change the time of saturation, and a smaller increased in size from 5 to 8 minutes.

The data obtained was used as a basis time apply the purpose of the photosensitizer in PDT, which was 5-7 minutes.

The suitability of the method is confirmed by the following clinical examples.

The patient Sapphire T.V., 36 years old, came with complaints of discomfort and discomfort in the mouth, bleeding gums when brushing your teeth and biting hard food.

Objectively: In the field 44, 43, 42, 41, 31, 32, 33, 34 teeth above - and subgingival dental plaque, periodontal pocket depth of 4 mm, mainly in the field of interdental spaces, mobility of teeth, their offset is expressed, celebrated bleeding, During inspection observed phenomena catarrhal gingivitis: it is revealed hyperemia, swelling of the gingival papillae. General condition is not violated. The radiological examination shows the initial degree of destruction of bone tissue interdental septa. The height of the interdental septa reduced by 1/3.

Diagnosis: Chronic generalized periodontitis mild severity.

Treatment: Initially assesses the condition of the oral hygiene of the patient, thus to control the used sanitary index. For the assessment of periodontal status were used index bleeding of Meulemann (SBI) in the modification Cole and index PMA, modified C.Parma (1960). To assess the hygienic condition of the mouth was used simplified index OHI-S for Greene-Vermillion (1964). In the CEN OHI-S was 1,62, its value was 3 times higher than normal; periodontal index PI was equal to 3.7; index bleeding SBI was 1.02.

Was carried out sanitation of the oral cavity. Recommendations were given, training, personal hygiene of the oral cavity, with the obligatory introduction to the everyday care of personal hygiene. The patient was conducted professional hygiene of the oral cavity by means of an ultrasonic device, monospecific curets of Langer, polishing brushes and pastes. Dental plaque removal by curettage of periodontal pockets. Conducted functional electoral presledovanie teeth.

On the next visit the patient held a session of photodynamic therapy with 1% toluidine blue as a photosensitizer.

Retraction thread previously were placed in a 1% solution of toluidine blue to full immersion. The exposure time of the yarn in the solution for 10 minutes. The thread was removed from the solution, allowed to drain the excess, cut off the required length.

On a previously isolated from the saliva of the gums, periodontal pocket was introduced retraction thread, pre-soaked in 1% solution of toluidine blue, on the depth of the pocket. The thread remained in the periodontal pocket for 5 minutes Then the thread was deleted. According to the fluorescent diagnosis was established that the value of normier the Anna fluorescence (FN) after application of the drug reached a maximum for 5 minutes. Then there was the impact on the treated areas of the gums laser radiation from a diode laser apparatus ALOG-01 series "Grenades" with output power of 0.4 watts with a wavelength of 689 nm in continuous mode. The energy density was 100 j/cm2. The exposure time of the laser radiation to the area of impact was 7 minutes.

After the treatment with photodynamic therapy, the patient had no complaints, and showed normalization of the clinical condition of the periodontium. The mucous membrane of the gums were pale pink, moderately moist, with no signs of edema, gingival margin densely covered teeth.

The hygiene index OHI-S was decreased in 5 times and its importance was 0,33; periodontal index PI was equal to 0; index bleeding SBI was 0.

Long-term (3 months) the presence of dental plaque was observed. The hygiene index OHI-S was 0,35; periodontal index PI was equal to 0 periodontal pockets are not detected; the index bleeding SBI was 0.

The patient Vasyutin, VA, age 37, had complained of bleeding gums, presence of dental calculus in the field 15, 14, 13, 12, 11, 21, 22, 23, 24, 25,

Objectively: In the field 15, 14, 13, 12, 11, 21, 22, 23, 24, 25, supra - and subgingival dental plaque identified periodontal pocket depth of 6 mm, mobility of teeth of the first degree, marked bleeding. During the inspection noted the effect catarrhal gingivitis: it is revealed hyperemia, swelling of the gingival papillae. General condition is not violated. The radiological examination revealed the destruction of bone interdental septa. The height of the interdental septa reduced from 1/3 to 1/2.

Diagnosis: Chronic generalized periodontitis of moderate severity.

Treatment: Initially assessed the status of oral hygiene of the patient, thus to control the used sanitary index. For the assessment of periodontal status used the index bleeding of Meulemann (SBI) in the modification Cole and index PMA, modified C.Parma (1960). To assess the hygienic condition of the mouth was used simplified index OHI-S for Greene-Vermillion (1964). Index OHI-S was 2,16; periodontal index PI was equal 4,48; index bleeding SBI amounted to 2.1.

Was carried out sanitation of the oral cavity. Recommendations were given, training, personal hygiene of the oral cavity, with the obligatory introduction to the everyday care of personal hygiene. The patient was conducted professional hygiene of the oral cavity by means of an ultrasonic device, monospecific curets of Langer, polishing brushes and pastes. Dental plaque removal by curettage of periodontal pockets under anesthesia. Conducted functional electoral presledovanie teeth.

On the next visit the patient who has held a session of photodynamic therapy with 1% toluidine blue as a photosensitizer.

Retraction thread previously were placed in a 1% solution of toluidine blue to full immersion. The exposure time of the yarn in the solution for 10 minutes. The thread was removed from the solution, allowed to drain the excess, cut off the required length.

On a previously isolated from the saliva of the gums, periodontal pocket was introduced retraction thread, pre-soaked in 1% solution of toluidine blue, on the depth of the pocket. The thread remained in the periodontal pocket for 7 minutes Then the thread was deleted. According to the fluorescent diagnosis was established that the value of the normalized fluorescence (FN) after application of the drug reached a maximum of 7 minutes. Then there was the impact on the treated areas of the gums laser radiation from a diode laser apparatus ALOG-01 series "Grenades" with output power of 0.4 watts with a wavelength of 689 nm in continuous mode. The energy density was 100 j/cm2. The exposure time of the laser radiation on the area of exposure was 6 minutes.

After the treatment with PDT in a patient with no complaints, improved oral hygiene and showed normalization of the clinical condition of the periodontium. The mucous membrane of the gums were pale pink color, with no signs of edema, gingival margin densely covered teeth.

The hygiene index OHI-S decreased 6 times and it is value amounted to 0.35; periodontal index PI was equal to 1.13; index bleeding SBI was 0.

Long-term (3 months) the presence of dental plaque was observed. The hygiene index OHI-S were 0.37; periodontal index PI was equal to 1.2, periodontal pockets are not detected; the index bleeding SBI was 0.

Additionally, I would like to note that this treatment was applied in 50 patients with satisfactory results.

For example, in patients with mild degree of severity of periodontal disease before treatment, there were complaints about bleeding gums when brushing.

After the treatment with PDT in patients with no complaints, and showed normalization of the clinical condition of the periodontium.

Inspection showed that the mucous membrane of the gums were pale pink color, with no signs of edema, gingival margin densely covered teeth.

After 12 months, according to the results of clinical examination of patients was determined condition clinically healthy periodontium.

X-ray picture was characterized by a decrease foci of osteoporosis, compaction compact plates, a suspension of bone resorption millionary partitions.

Thus, the clinical picture was characterized by persistent positive clinical dynamics.

A similar picture is also observed and the ri treatment of periodontitis of moderate severity.

In groups, where in the complex treatment was applied PDT achieved positive dynamics of clinical periodontal status was more stable.

A method of treating periodontal disease comprising removing the patient's dental plaque, tooth polishing, curettage of periodontal pockets, functional presledovanie teeth and photodynamic therapy using a photosensitizer, wherein the patient treatment with photodynamic therapy using an aqueous 1% solution of toluidine blue as a photosensitizer, for this pre-retraction thread is placed in a 1% aqueous solution of toluidine blue to complete immersion in the solution, the exposure time of the yarn in the solution is about 7-10 minutes, after which the previously isolated from the saliva of the gums, the periodontal pockets in the area affected teeth group, enter the retraction thread previously sustained in an aqueous solution of 1% toluidine blue, the entire depth of the pockets, the thread is left in the pockets for 5-7 minutes and then remove it, then hold the action of laser radiation on the processed photosensibilisation periodontal pockets.



 

Same patents:

FIELD: medicine.

SUBSTANCE: method of treating periodontitis involves dental deposit removal, dental polishing, curettage of gingival pockets, functional dental grinding and photodynamic therapy with using a photosensitiser with performing a session of photodynamic therapy using 1% aqueous methylene blue as a photosensitiser; for this purpose, a retraction cord is placed into 1% aqueous methylene blue until immersed completely; an exposition time in the solution makes 7-10 minutes; thereafter, the retraction cord kept in 1% aqueous methylene blue is inserted onto a gum pre-isolated from saliva in the gingival pockets completely within an involved group of teeth for 5-7 min and removed then; further, the gingival pockets treated with the photosensitiser are exposed to a laser light.

EFFECT: possibility to avoid complications related to recurrent photodynamic procedures and occurred when using the gel and installation photosensitisers, enables maintaining the concentration of the drug introduced into the gingival pocket immediately, and higher effect of the photodynamic therapy on microbial flora of periodontal pocket biofilm.

2 ex

FIELD: medicine.

SUBSTANCE: chewable substrate contains a chewable base and an herbal extract as an active substance, wherein as the extract, the substrate contains a condensed red-haw hawthorn polyextract 10.0 g dried to residual humidity 25%, while the base is presented by sorbitol 40.0 g, apricot gum 15.0 g, gelatin 10.0 g, citric acid 1.0 g and purified water 100.0 g. The chewable substrate is applied 3 times a day for 15 minutes for 2 weeks, taken in a quantity of 1 substrate chewable until dissolved completely at an average weight of one substrate of 4.0 g.

EFFECT: using the method enables reducing oral xerosis, prolabium, coated tongue, rate of burning mouth syndrome, burning sensation and bad taste, normalising physical-chemical characteristics of the oral fluid.

4 tbl, 1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to the field of antimicrobial preparations and deals with compositions, which contain an antimicrobial agent and a compound, which is efficient for enhancement of the antimicrobial agent action. A composition for prevention and/or treatment of oral cavity diseases contains a carrier, an antimicrobial preparation and a compound, selected from the group of chalcones, consisting of 3-(4'-hydroxy-3'-methoxyphenyl)-1-(2'-hydroxy-5'-methoxyphenyl)prop-2-en-1-one, 3-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-prop-2-en-1-one, 3-(2",3"-dimethoxyphenyl)-1-furan-2-yl-prop-2-en-1-one, 3-(2",5"-dimethoxyphenyl)-1-(1H-pyrrol-2-yl)prop-2-en-1-one and their mixtures. The composition is preferably made in the form of a tooth-cleaning preparation.

EFFECT: application of the said chalcones in a combination with antimicrobial preparations considerably enhances efficiency of the antimicrobial preparations.

15 cl, 12 tbl, 16 ex

FIELD: medicine.

SUBSTANCE: method of treating apical periodontitis involves necrectomy from root canals, mechanical treatment thereof, root canal widening with multiple administration of a solution therein, insertion of a drain sponge wetted with the solution into the root canals left until the next doctor's appointment, root canal orifice closure with a dressing, root canal opening 48 hours later, dressing removal from the root canals, processing with 2% aqueous sodium hypochlorite, and gutta-percha filling. Mechanical treatment involves multiple introduction of a butol solution; mechanical treatment is followed by inserting drain sponges wetted in the butol solution into the root canals, or by introducing mixed zinc sulphate cement with butol with using a root canal filling instrument.

EFFECT: provided haemostatic effect in the root canal, optimal drug diffusion into the root canal tissues, and an anti-inflammatory action.

2 ex

FIELD: chemistry.

SUBSTANCE: group of inventions relates to compositions of materials, containing basic aminoacid arginine, and their application for coating devices intended for application in the oral cavity, or for manufacturing such devices. One of composition versions contains basic amino acid arginine, in free form or in form of salt, placed in biodegradable polymer, selected from polyacrylates, polymethacrylates or their copolymers. The other composition version contains matrix with pores from 10 to 70 mcm and basic amino acid arginine, located inside said pores, with matrix representing plastic, selected from polyethylene, polymethylmethacrylate, polyurethane, polyethylene terephthalate, polypropylene, polystyrene, polyamides, bioplastic. Also claimed is application of said compositions of material in production of device for application in the oral cavity, as well as device for application in the oral cavity (for instance, toothbrush, tongue scraper, mouthguard, orthodontic correcting device), which has a surface coated with any of said compositions, and methods of delivery of basic amino acid arginine by means of such device into the oral cavity of a subject, requiring it.

EFFECT: application of such devices, manufactured with application of said compositions, ensures release of arginine into the oral cavity within a long period of time.

22 cl, 5 ex

FIELD: medicine.

SUBSTANCE: method of treating periodontitis provides professional hygienic oral cleansing, antiseptic therapy, local drug-induced therapy. The local drug-induced therapy is two-staged with the use of zeolite-containing fossil flour with particle size of 0.3-0.4 mm. The first stage involves gingival infriction of a mixture consisting of zeolite-containing fossil flour and distilled water taken in equal weight parts for 10-15 min; the second stage includes applications of tampons impregnated with a mixture containing 2.5-3 weight parts of fossil flour and 1-1.5 weight parts of distilled water on the affected gingiva; the length of the local drug-induced therapy is 12-14 days.

EFFECT: effective treatment of periodontitis enables stable reduction of periodontal inflammation, fastening the remission time and reducing the number of aggravations.

2 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: what is used is a preparation in the form of an ointment of the following composition: 70% infusion of Rhaponticum carthamoides rhizomes and roots or Silene tatarica herb - 10.0 ml, 70% infusion of St. John's wort herb - 5.0 ml, 70% infusion of calendula - 5.0 ml, 70% infusion of spiraea - 5.0 ml, clove essence - 1.0 g, Vaseline - 35.0 g, lanolin - 39.0 g used to coat a mucous membrane of the hypertrophied gingiva as an applicate for 15-20 minutes once a day for 14 days; abstaining from food for 2 hours is recommended.

EFFECT: manifested therapeutic effect in treating hypertrophic gingivitis, particularly by providing anabolic, capillary strengthening, anti-inflammatory action with retention of the effect for a long period of time.

2 ex

FIELD: medicine.

SUBSTANCE: method for prevention of dental caries with using a suspension of the biologically active additive 'Epsorine' involves applications of the suspension either daily, or every second day; the daily procedures contain min 4 applications of the total treatment time up to 20 minutes; the prevention course makes 10 procedures. Besides, the prevention course is repeated 2-3 times a year every 3-4 months for the main indication.

EFFECT: higher caries stability of dental tissue.

3 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to dentistry and concerns preparing an oral care agent. For this purpose, a kit comprising an optically transparent composition containing a photosensitising dye, and a light-emitting device emitting light at a wave length and over a period of time sufficient to activate the photosensitising dye is presented. The above dye is specified in a group consisting of chlorophyllin sodium copper salt, tartrazin (FD&C yellow No.5), riboflavin-5'-monophosphate sodium salt, Allura Red AC (FD&C red No.40), new coccine (CI 16255, edible red 7), chromotrope FB (CI 14720, edible red 3), indigo carmine, erioglaucine disodium salt (FD&C blue No.1), fast green FCF (FD&C green No.3), lissamine green B, naphthol green or acid green, cochineal, carmoisine azorubin, amaranth, brilliant scarlet 4R, complexes of copper and chrolophyl, brilliant black BN (PN), chocolate brown HT, β-carotin, bixin, lycopene, betanin, Erythrosin B sodium salt and mixtures thereof. The optically transparent oral care composition contains a negligible amount of titanium dioxide and 3% or less of silicone dioxide.

EFFECT: invention provides effective treatment and/or prevention of conditions caused by microorganisms by creating strong antibacterial activity with non-toxicity and safety of the used dyes.

16 cl, 3 ex, 14 tbl

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely therapeutic dentistry and may be used for treating destructive forms of chronic periodontitis. That is ensured by administering a therapeutic preparation into a root canal. A sonic phoresis of the therapeutic preparation Beresh plus drops is preceded by coating the skin surrounding a causative tooth with a therapeutic mixture containing the preparation Beresh plus drops, 10% calcium gluconate and Vaseline oil. Thereafter, an emitter is used to process the area. The sonic phoresis is followed by a root canal obturation with calcium hydroxide. That is combined with administering ascorbic acid in a daily dose of 50-100 mg and the preparation Beresh plus drops 1 drop per 2 kg of body weight a day orally. The therapeutic course is 5-8 procedures.

EFFECT: invention enables arresting the inflammatory process in the aggressive lesion, reducing the number of complications and aggravations ensured by accelerating the repair processes in the apical aggressive lesion.

2 dwg

FIELD: medicine.

SUBSTANCE: method of treating periodontitis involves dental deposit removal, dental polishing, curettage of gingival pockets, functional dental grinding and photodynamic therapy with using a photosensitiser with performing a session of photodynamic therapy using 1% aqueous methylene blue as a photosensitiser; for this purpose, a retraction cord is placed into 1% aqueous methylene blue until immersed completely; an exposition time in the solution makes 7-10 minutes; thereafter, the retraction cord kept in 1% aqueous methylene blue is inserted onto a gum pre-isolated from saliva in the gingival pockets completely within an involved group of teeth for 5-7 min and removed then; further, the gingival pockets treated with the photosensitiser are exposed to a laser light.

EFFECT: possibility to avoid complications related to recurrent photodynamic procedures and occurred when using the gel and installation photosensitisers, enables maintaining the concentration of the drug introduced into the gingival pocket immediately, and higher effect of the photodynamic therapy on microbial flora of periodontal pocket biofilm.

2 ex

FIELD: medicine.

SUBSTANCE: method involves a dietary therapy, taking mineral water in an amount of 100-150 ml, 3 times a day and exposure to a physical factor. What is used is the Pevzner's diet No. 5. Karachinskaya chloride-hydrocarbonate sodium gas-free mineral water of total mineralisation up to 3 g/dm3, at a temperature of 38-40°C is taken 30-40 minutes before a meal. The physical factor represents a magnetic laser therapy and an EHF therapy. The contact magnetic laser therapy covers three zones sequentially at a frequency of 5 Hz: an epigastric zone and the right and left upper hypochondria along the midclavicular lines, for 4 minutes for each zone within the course of 10 procedures. The EHF therapy involves combined exposure on two projection zones: in the right hypochondrium and on the sternum generated by a broadband noise emitter at an emission frequency of 40-63 GHz, for 20 minutes, every day within the course of 10 procedures.

EFFECT: method provides more effective rehabilitation treatment following endoscopic cholecystectomy ensured by the early integrated therapeutic exposure.

2 ex, 4 tbl

FIELD: medicine.

SUBSTANCE: postoperative period involves tamponage with Coletex-AGGDM wet tissue within middle nasal passages. The tamponage area is exposed to laser light in the infrared band at a wave length 0.95 mcm at the output power of 2-3 mWt for 4-5 min. After the exposure, the tissue is left for one day. The following procedures are performed with the tissues placed in the middle nasal passage within a natural fistula and on a mucous membrane of a hard palate in a projection of a maxillary sinus bottom. The tamponage area and skin in the projection of the maxillary sinus within an anterior sinus wall are exposed. 2-3 procedures are performed at the output power of 5-7 mWt for 7-10 min for one field. 4-6 procedures are performed at the power of 15-20 mWt for 3-10 min for each field. After the exposure is terminated after each procedure, the endonasal tissue is left for 6-8 hours.

EFFECT: method enables providing higher clinical effectiveness by antibacterial, antiseptic, anti-oedematous effects, recovering the ciliary transport function without injuring the ciliated epithelium; eliminating the postoperative complications, such as sinus bleeding and cicatrical deformity of the mucous membrane.

2 ex

FIELD: medicine.

SUBSTANCE: pathological vertical venovenous reflux is eliminated by laser obliteration of subcutaneous veins. The laser obliteration is preceded and followed by an endovenous electrical myostimulation.

EFFECT: method enables eliminating the pathological vertical venovenous reflux effectively accompanying chronic venous insufficiency, providing higher clinical effectiveness, reducing the number of injuries and a probability of a thermal injury of paravasal tissues.

3 cl, 2 ex, 2 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medical equipment, namely to devices for laser irradiation of biological objects when exposed to a damaging effect of ionising radiation in experiment. The device comprises an emitter and an adapter supply unit. The emitter consists of four emitting assemblies comprising laser modules at wavelength 650 nm having the same powers ensured by individual adjustable resistors, through which they are connected to the adapter, and divergent lenses. On a supply input, there is a timer connected to the adapter. The timer sets a time providing irradiation of biological objects by a laser irradiation dose of 1 mJ/cm2.

EFFECT: using the device enables the one-start radiation of a greater area of the object in an accurate effective dose.

2 dwg, 1 tbl

FIELD: medicine.

SUBSTANCE: invention relates o medicine and can be applied in treating varicose disease of veins of lower extremities with application of endovenous laser vein coagulation (ELVC). For this purpose skin area, which is subjected to operation, is processed with antiseptic solution. Under control of ultrasonic apparatus into vessel lumen introduced is catheter, through which light-conductor is passed to saphenofemoral fistula. After that, tumescent anesthesia is performed by creation of water "cushion", at that applying cold, ozonised 0.9% physiological solution with temperature 5-7°C, ozone concentration 4-5 mcg/ml and time of saturation with ozone 5-8 minutes. Or ozonised 0.1% lidocaine solution with temperature 5-7°C, ozone concentration 4-5 mcg/ml and time of saturation with ozone 5-8 minutes is introduced. After that, pathological vessel is exposed to laser energy. If necessary, applications of 50 ml ozonised heparin-containing gel are made after procedure in projection of coagulated vein with exposition 60-90 minutes until ozone concentration of gels reaches 6500-7000 mcg/ml.

EFFECT: method ensures effective treatment of said pathology due to selection of most optimal type of anesthesia and following therapy, which contribute to reduction of pains, local manifestations of inflammation, activation of processes of focal and marginal epithelisation processes.

2 cl

FIELD: medicine.

SUBSTANCE: photosensitiser Photosense is administered. The patient is irradiated with using an optical fibre with a lens on a distal end in contact with a chest wall along intercostal spaces in 8-10 random positions for 1 therapeutic session. A light dose of one position of the laser radiation is 100 J, and an output power is 200-250 mWt,.

EFFECT: method provides regression of the tumoural process, obliteration of the pleural cavity without the aggressive intrapleural intervention, and eliminates potential infections.

2 ex

FIELD: medicine.

SUBSTANCE: with underlying antiviral therapy, blood is exposed intravenously to wave length 365 nm first, emission power 2 mWt, exposure 2 minutes. On the next day - at wave length 530 nm, emission power 2 mWt, exposure 8 minutes. There are 15 sessions of intravenous laser blood irradiation prescribed.

EFFECT: terminated reactivation of urogenital cytomegaloviral infection, reduced length of the following recurrent cases, prolongs an intercurrent period and promotes the clinical course of the viral infectious process transformed into a persistence ensured by stimulation of an inadequate immune response, normalises the interferon status and suppression of the hyperactive processes.

2 ex

FIELD: medicine.

SUBSTANCE: starch or sorbite photosensitiser powder is administered into a laryngeal pharynx that is further exposed to laser light. The laser light exposure is performed at wave length 0.685 mcm, powder 18-20 mWt, energy density 18-28.8 J/cm2.

EFFECT: implementing the method provides the reliable laryngeal fixation of the photosensitiser, maintains the constant concentration of the photosensitiser for the whole therapeutic session, and thereby faster reduction of the inflammatory process.

2 cl, 4 ex

FIELD: medicine.

SUBSTANCE: method involves reflex therapy (RT) alternated with taking general baths every second day. The RT is conducted by inserting needles into corporeal points and microneedles into auricular points of the systemic effect on the 1, 5, 9, 13, 17, 21 procedures and executing the electric acupuncture of the paravertebral points on the 3, 7, 11, 15, 19 and 23 procedures. If the patients shows predominating psychoasthenic symptoms, iodine bromine baths are taken. The baths contains potassium iodide 50 mg/l and potassium bromide 125 mg/l. Water temperature is 36-37°C. If the vegetative imbalance predominates in the patients, radon baths with the radon concentration of 40-80 nCu/l are taken. Water temperature is 26-28°C. That is combined with the following laser therapy. The laser therapy is generated by Mlada apparatus. What is used is a continuous infrared light at wavelength 0.85 mcm, total output power of the two emitters 30 mWt. The patient is exposed by the standard procedure. The exposure covers 4 fields: a collar, an apex of heart, a middle one-third of chest and a left infrascapular region. The exposure length is 1 minute from 1st to 3rd procedure, 2 minutes from 4th to 6th procedures, and 3 minutes starting from the 7th procedure.

EFFECT: method improves the psychoemotional state of the patients thereby normalising the vegetative balance, and improves the working efficiency.

FIELD: medicine.

SUBSTANCE: method of treating periodontitis involves dental deposit removal, dental polishing, curettage of gingival pockets, functional dental grinding and photodynamic therapy with using a photosensitiser with performing a session of photodynamic therapy using 1% aqueous methylene blue as a photosensitiser; for this purpose, a retraction cord is placed into 1% aqueous methylene blue until immersed completely; an exposition time in the solution makes 7-10 minutes; thereafter, the retraction cord kept in 1% aqueous methylene blue is inserted onto a gum pre-isolated from saliva in the gingival pockets completely within an involved group of teeth for 5-7 min and removed then; further, the gingival pockets treated with the photosensitiser are exposed to a laser light.

EFFECT: possibility to avoid complications related to recurrent photodynamic procedures and occurred when using the gel and installation photosensitisers, enables maintaining the concentration of the drug introduced into the gingival pocket immediately, and higher effect of the photodynamic therapy on microbial flora of periodontal pocket biofilm.

2 ex

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