Method for correction of morphofunctional status of sportsmen
SUBSTANCE: food ration is added with multi-component natural concentrated food products (NCFP) with high concentrations of biologically active substances (BAS) of herbal (HNCFP) and (or) protein-herbal (PHNCFP) raw material, for the purpose of nutritional support of sportsmen doing various sports, their individual physiological requirements; that results in recovering a set of characteristics of physiological functions and qualities determining a degree of activity of morphofunctional body systems, activities of daily living and professional performance, with providing preventing donozological and pathological conditions, achieving high sport scores. The above food products can be presented by NCFP Antitox and NCFP SportAtiv-2.
EFFECT: invention provides easier exercise tolerance and recovery thereafter, improving health in sportsmen.
The technical field to which the invention relates.
The invention relates to medicine, nutritional health, in particular to a method of correction of the functional state of athletes by including in their diet natural concentrated food (NCP) with high content of biologically active substances (BAS) and thereby replenish the physiological needs of the body the nutrients to achieve high results, save occupational health, prevention of psycho-physiological and pathological conditions.
The level of technology
The achievement of high results in sports depends mainly on genetic characteristics of the athlete, as well as morphological, physiological, psychological and metabolic characteristics of the organism that are necessary to ensure high performance during intense training and competition in a specific sport. Genetically gifted athletes need to train optimally, to increase physical strength, psychological readiness and technical advantage. Therefore many athletes and their coaches use a variety of strategies, implement measures to improve the organization and efficiency of the training process, the cat is who, they assume are effective, safe, ensuring optimal physical performance to achieve desired results in sports competitions and permitted by law .
To date, there are ways of correction of morphological or functional status of athletes (with emphasis on the regulation of emotional characteristics and (or) the effectiveness of muscle health) using tools and techniques of physiotherapy (Spa treatments, the effects of different light spectrum and the sound of different frequencies of the pulse and so on), psychotherapy and hypnosis, pharmacological effect.
A special place in achieving the desired results given the use by athletes of different feeding strategies, including the use of food additives (sports supplements), specialized food products (SEPS) with a given food and energy value, which ideally should take into account sports (including phases of athletic activity and the individual characteristics of the athlete, or should be presented in such a range that allows you to calculate the optimum combination of nutrients that meet the first two requirements [4, 18].
As examples, here are some of the local ways of influence on the organism of sportsmen for the purpose of correcting their psychosomatic, morphofunctional state and the subsequent increase efficiency, which can be considered as analogs of the present invention [7-12]:
- "The way to improve physical performance in athletes of high qualification" (EN 2016564 C1, 30.07.1994). The invention relates to medicine, physiotherapy, sports medicine to improve physical rehabilitation in athletes of high qualification. The essence of it is that the athletes after the first workout, and for 2 h until the next spend turpentine baths from yellow solution concentration of from 45 to 65 ml per 200 l of water with temperatures ranging from 38 to 41°C, the duration of 15-20 min, in the course of 6-8 treatments. The invention is intended to accelerate the recovery of athletes in improving their psychological state.
This method has the following disadvantages: first, the classical method of appointment and conduct turpentine baths provides a number of strict contra-indications, limitations and conditions (including, idiosyncrasy; strict individual approach (Zalmanov A.S. , Kaminsky V.B. have been
the founders of the method of application of turpentine baths; Internet resource http://www.domkurorta.ru/skipidar.html in observance of stages, time and temperature parameters vacation procedures; continuous monitoring of zaostajanjem patient and the conditions for termination of the procedure), which are not specified in the method; second, initially in the method adopted to use the upper levels of the yellow solution, water temperature and duration of the procedure, which can cause in the absence of strict medical control - the deterioration of the General condition, complications even in healthy athletes; third, the General procedure lasts 2-3 hours, taking into account the mandatory time to rest (at least 1-2 hours, based on the patient's condition) after taking a bath, which is extremely problematic in terms of the way - "...for 2 hours before the next trainings are carried out of the bath..."the more perform substantial physical activity immediately after the procedure , which is also not specified in the method; fourth, the purpose of impact is to correct only one functional parameter (recovery of athletes);
"Correction method of the autonomic balance of the body athletes" (EN 2373935 C1, 27.11.2009). The invention relates to medicine, namely to physiotherapy and sports medicine. Record the heart rate variability (HRV) at rest and hope: the ratio LF/HF index subcortical nerve centers (PPNC), tension index (ti), an index of autonomic balance (IIA), vegetative indicator rhythm (CDF), the adequacy is Rzeszow regulation (PAPR). Then repeat the survey after the presentation of mental exercise stress test and when at rest, the parasympathetic type regulation of the autonomic nervous system, when the LF/HF ratio is less than 0.5; and/or IN less than or equal to 50; and/or IIA is less than or equal to 35; and/or VIR less than or equal to 3.5; and/or VLF more than 150 points and/or by reducing PAPR after mental stress test exercise effect on the eye is red or orange. If the rest of the state of autonomic balance or sympathetic type regulation of the autonomic nervous system, when the LF/HF ratio greater than 0.5 and/or IN more than 50 and/or more than 35 PSI and/or VLOOKUP more than 3.5 and/or VLF less than 150 points, and/or increase PAPR after mental stress test affect eyes green or blue light. Sessions the impact of color carry out daily from the "ASEC", with repetition frequency of the pulse light of 9.2+0.2 Hz, a duration of 5-6 with, alternately on each eye for about 8 minutes in the first half of the day after a morning workout, a course of 10 treatments, daily. The method expands the Arsenal of tools for the correction of autonomic balance in the body of athletes.
This method has the following disadvantages: firstly, the way monofunctional, the purpose of which is to correct only one parameter - the autonomic balance of the body athletes; secondly, those which automatic difficult to implement, long time, the material is highly costly, requires complicated mathematical calculations to identify the various indices and indicators;
- "A way to improve the emotional state of the organism of athletes" (EN 2469730 C2, 20.12.2012). The invention relates to the field of sports medicine, in particular to the field of pharmacology sport. The method includes conducting psychotherapy. Additionally, drug use Cortexin, which is administered intranasally in two stages. During the first phase of Cortexin administered for 10 days at a dose of 0.5-2 mg for 30-40 minutes before the start of the training process. During the second stage of Cortexin enter within 10 days at a dose of 0.25 to 1 mg after 1.5-2 hours after completion of the training process. The method, according to the authors, allows to optimize the psycho-emotional status in athletes and to achieve high results during training and competition process.
This method has the following disadvantages: first, as discussed above, in its impact is monofunctional, the purpose of which is to correct only one parameter - the achievement of an optimal emotional state of the organism of sportsmen; secondly, in addition to the basic psychotherapeutic effects of organizersmartdraw in the way of use and the pharmacological through neuropeptide drug Cortexin (affects the nerve cells of the brain), which, as the drug has not only the indications for use, but also contraindications (in particular, individual intolerance of the drug) and at least limit, or do not always installed in the development and production of medicines, side effects. In the description of Cortexin as side effects are specified allergic reactions (online resource: webapteka.ru, womenhealthnet.ru, risnet.ru), is released from pharmacies by prescription;
"The method of using dietary supplements in the diet of athletes" (EN 2156086 C1, 20.09.2000). The invention relates to the field of food industry. During peak loads in the diet of athletes enter in the amount of 4-5 mg per 1 kg of body weight of the athlete preparation containing adaptogens, detoxifier, vitamins, micro - and macronutrients. As adaptogene use artichoke syrup. As a detoxifier use shell yeast Saccharomyces cerevisiae with electrokinetic potential from 15 to 75 mV. The drug contains artichoke syrup in the amount of from 28.5 to 32.5 wt.%, and shell yeast - from 32,4 up to 47.2 wt.%. And as a source of multivitamins, as well as micro - and macro use vegetables and fruits in powder form. It has the ability to overcome the state of immuno is eficit in athletes during peak loads on his body.
This method has the following disadvantages: first, as all the previous ones, its impact is monofunctional, the purpose of which the adjustment of only one parameter - the state of immunosuppression in athletes; secondly, the method involves the use of the additive as an additional power athletes without regard to physiological needs and characteristics of their body and only in a limited area of the training process (peak);
"Product "sportmen for power athletes" (EN 2306720 C1, 27.09.2007). Purpose and content of this method is to provide the body easily and quickly by protein substrates (amino acids - donators energy), improving muscle health by accelerating the recovery of the energy potential of protein cells after physical exertion, with the use of the product based on amino acids, with the addition of the complex of plant dietary fiber. Intended for use as an additional power athletes.
This method has the following disadvantages:
its impact is monofunctional, the aim of which one correction parameter is increased muscle health of athletes through the replacement and / or maintenance, higher is the major physical exertion, the energy needs of the muscle;
judging from the ingredients and in the host parameter of the purpose of, for correction of a status of an organism of sportsmen in the way it uses the protein product is not fully digested proteins which in the form of fragments of their chains of polypeptides, can cause allergic reactions  (long-term use, individual characteristics of the organism);
the method involves the use of the product as an additional power athletes;
adopted in the way the product is formed mainly due to the synthetic protein complex with the addition of vegetable dietary fiber (including, flavoring additives), which are always simple chemical substances;
in the formulation of the product is missing a vitamin-mineral complex and minor components that significantly affect the metabolic processes of the body, which also significantly reduces its functionality;
- "Specialized protein for power athletes" (EN 2375923 C2, 20.12.2009). Purpose and content of this method is to provide the body protein substrates and other components (vegetable dietary fiber, vitamin and mineral premixes for the normalization of the state of protein metabolism and increase the nutritional value of the product is, taste and aroma additives)that contribute to enhancing muscle mass and recovery process after exercise, reducing the period of adaptation to physical loads and environmental conditions, to maintain immunity and decrease in body fat, increase explosive muscular strength and endurance, improve mental stability and health of athletes. Intended for use as an additional power athletes.
This method of correction of athletes through the use of sports nutrition product has several disadvantages:
the leading method in the end is to improve the health of athletes on the basis of the normalization condition only protein metabolism. Possible changes of other States of the body (muscle mass, adaptation to physical activity, maintaining the immune system, increase explosive muscular strength and so on) are treated in the way as an intermediate phase in the achievement of the leading purposes and are not intended to replace many other important physiological needs, prevention of psycho-physiological and pathological conditions;
as in the previous method, based on the composition of ingredients and the host parameter of the purpose of, for correction of a status of an organism of athletes use protein product of the E. fully digested proteins which in the form of fragments of their chains - polypeptides, can cause allergic reactions ;
the method involves the use of the product only as additional power athletes;
adopted in the way the product is formed mainly due to the synthetic protein and vitamin-mineral complexes (including, flavoring additives), which are always simple chemical substances; in addition, according to some authors, synthetic vitamins can cause toxic reactions .
The principal difference of the invention from the other ones is the fact that by the inclusion in the diet of athletes multicomponent NCP with a high content of biologically active substances from plant (NCPRS) and (or) protein and vegetable raw materials (NCPPS), is the restoration of the totality of characteristics of the morphological status and physiological functions, which determine the level of activity of functional systems of the body, especially the activity and status of occupational health, ensuring the prevention of psycho-physiological and pathological conditions and thus the achievement of high sports results athletes of different sports.
The closest analogue of the present invention on the objectives, principles and means of its achievement are the two who is "Specialized protein for power athletes" (EN 2375923 C2, 20.12.2009), which is adopted for the prototype (discussed above).
Disclosure of inventions
A promising direction for effective problem solving correction of functional state of organism of athletes (mainly catalytic needs) is to optimize their nutrition by including in the diet of food with high content of biologically active substances of natural origin from vegetable or plant-protein raw materials, first of all vitamins, minerals and protein of animal origin.
The role of vitamins in sports nutrition is described in detail in the scientific literature. It is known that lack of vitamins disrupts metabolism. The specific function of most vitamins is that they are in the form produced from them in the body of coenzymes or prosthetic groups are part of the active centers of proteins, coenzymes and thus participate in the mechanisms of enzymatic catalysis of various reactions of metabolism that underlie all life processes and functions of the organism . This fact is crucial for the maintenance of homeostasis and the regulation of metabolism, since the biosynthesis of a protein part of the enzyme and its functioning as a whole are the main points ol the provisions diverse regulatory mechanisms integration of metabolism and its adaptation to changing internal needs and external conditions . The role of individual vitamins in certain biochemical processes in the body.
The main food sources of vitamins are vegetables, fruits, berries, vegetable and animal oils, meat, milk.
Minerals along with protein, carbohydrates, fats and vitamins are vital components of human food needed to build chemical structures of living tissues and implementation of biochemical and physiological processes that underlie the functioning of the body. Minerals perform plastic function in the vital processes of the body. Their deficit violates the most important metabolic processes in the body water and electrolyte, acid-base, many enzymatic processes. Especially important for athletes provision of such minerals as iron, copper, manganese, because of their deficiency leads to iron deficiency status and associated with erythropoiesis, tissues and cells with oxygen and physical health.
Minerals in the body act as activators or inhibitors of various enzymes. State of deficiency, excess or imbalance of minerals in which organisme lead to microelementoses, reflecting on human health, including athletes [14, 15].
To compensate for vitamin and mineral deficiency of the body at the present time quite often, including in sports nutrition, use synthetic vitamin-mineral complexes. However, they are inferior to natural, because the synthetic product is always simple, chemical, and natural - is a complex mixture of related substances. Synthetic vitamins can cause toxic reactions, while natural vitamins, even in large enough doses that do not cause. Although synthetic vitamins and minerals gave satisfactory results, the benefits of natural vitamins more on many levels. Chemical analysis of both types of nutrients may seem the same, but this is not all that there is in natural vitamins, and not everything that is connected with these substances in nature. Synthetic vitamin C is only ascorbic acid and nothing else. Natural vitamin C from rosehips contain bioflavonoids, a complex of vitamin C, making it much more efficient. Natural vitamin E, which can include all the Tocopherols, not just alpha-tocopherol is more effective than its synthetic counterpart. Many, CT who have tried both types of substances, I can confirm that after taking natural substances was observed less gastro-intestinal disorders. And, most importantly, synthetic vitamins can cause toxic reactions, while natural vitamins are not, even when they are taken in doses more than usual .
It is known that for normal functioning of the body and all its systems are required not only vitamins and minerals (balanced vitamin-mineral complexes), and a much wider complex of natural components of the food to which people adapted, in particular minor substances, which are present only in plant material. The latter, not having the energy and plastic values, have diverse physiological effect on the body. So, bioflavonoids have antioxidant properties by inhibiting the oxidation of low density lipoproteins and endogenous vitamin E, formation of chelate complexes with metal ions and binding of free radicals; preventing the formation and release factors to the promoters of inflammation and destruction of tissue; regulating the activity of enzymes in the metabolism of xenobiotics. Dietary indoles and isothiocyanates able to induce the activity of the monooxygenase system, enzyme inducers II the basics of metabolism of xenobiotics .
The achievement of high sports results associated with significant physical and psychological stress, which are constantly subject to professional athletes. Sports of the highest achievements comes amid maximum use of functional resources of the body, which affects the health, quality of life athletes. Biochemical mechanism of metabolic disorders in the body when stress has a universal character: intensifies the formation of oxidative free radicals, which becomes avalanche-like character. Free oxidative radicals damage the cell membrane, lipid structure, result in a violation of homeostasis. So important is the inclusion in the diet food components that play an important role in protecting the body from free radical processes. Among them vitamins (a, C, E, folic acid and others), minerals (selenium, zinc, manganese, iron and others) and minor components of food plants (bioflavonoids, carotenoids, indoles, and other) .
The main source of vitamins, minerals and minor components are plants and, consequently, plant foods .
Optimal systems, including all these elements - NCP from vegetable or protein-vegetable raw materials produced by technology of cryo the military grinding. In addition to vitamins and minerals, the content of which is 6-8 times higher than their content in the feedstock, these NCPP contain the body needs dietary fiber and minor substances.
The final products from vegetable raw materials, processed by the method of low-temperature drying followed by grinding at low temperatures are fine klopotoski, which have a higher bioavailability of biologically active substances when they are eaten. The use of one gram of the concentrate is similar to the use of 700-1000 grams of fresh fruit or vegetables .
Research bioproof-readers showed that as a result of implementation of the whole technological cycle of processing on the proposed technology is an increase in the content of biologically active substances in the final product: for example, in the course of the experiment in black mountain ash content of carotenoids increased by 1.84 times, thiamine - 16,0 time, vitamin E - 10.0 times; in cranberries content of thiamine increased 11.0%, Riboflavin - 12.0 times.
The removal of moisture from the vegetables and fruits significantly increases the extraction properties of the product and the degree of assimilation. Concentration of dietary fiber, microstructurally and therefore a large active surface NCP gives them the properties of the sorbents.
Special studies have shown bi the sorption activity of some bioproof-readers in relation to toxic metals lead and cadmium. Most effectively absorb and excrete these toxins can the following bioproof-readers: eggshell (88% and 94%, respectively), pumpkin (80 and 86%), parsley (94 and 86%), celery (93 and 88%), blueberries (70 and 85%), oats (82 and 88%), raspberry (75 and 77%), dill (63 and 73%), Jerusalem artichoke (67 and 86%), carrots ( 62%and 42%), Apple (52 and 73%), Aronia (63 and 72%).
The present invention is to develop a method of correction of the functional state of athletes, ensuring the prevention of the development in their body psycho-physiological and pathological conditions and consequently the achievement of high sports results. The problem is solved by the proposed method, based on the restoration of the totality of characteristics, physiological functions and qualities that determine the level of activity of functional systems of the body, especially the activity and status of occupational health of athletes.
The technical result of the present invention is the rationale, development and inclusion in the diet of multicomponent natural concentrated food (NCP) with high content of biologically active substances (BAS) of the plant (NCPRS) and protein-vegetable raw materials (NCPPS) taking into account the purposes of nutrien the active support of athletes of different sports, their individual physiological needs and characteristics.
The proposed method in comparison with analogues and prototype technically simple and psihofiziologicheskie adapted to everyday life and activities of a person of any profession (any occupation, in our case - athletes of various sports); does not require any additional tests and complex calculations in the formation of even a multicomponent NCP; no need for additional psychotherapy, hypnosis, and other effects and, most importantly, the use of any pharmaceutical products; allows you to simultaneously perform the correction of the aggregate indicators of the functional state of athletes, using only NCPP from vegetable or protein-vegetable raw materials with high content of biologically active substances, and NCPP, manufactured by cryogenic technologies have a higher biodecomposition BAS when they are eaten than any other product.
The achievement of the technical result is ensured by the fact that in the method for the correction of the functional state of athletes in the diet include multicomponent natural concentrated foods with a high content of biologically active substances of vegetable and protein-vegetable raw materials with regard to CE is her nutriention support of athletes of different sports, their individual physiological needs; the consequence of which is to restore the totality of characteristics, physiological functions and qualities that determine the level of activity of functional systems of the body, especially the activity and status of occupational health and ensuring the prevention of psycho-physiological and pathological conditions, the achievement of high sports results.
The present invention is fundamentally different from the prototype that we developed an original method for correcting a set of indicators of the functional state of athletes on the basis of use as the base of their food NCP with a high content of biologically active substances.
In addition, it is important to note that this method mainly differs from analogs and prototypes that:
- for the correction of the functional state of athletes use only NCPP from vegetable or protein-vegetable raw materials with a high content of biologically active substances, including minor components manufactured by cryogenic technology; and exclude the use of any pharmacological agents and flavoring additives;
- for the correction of the functional state of athletes in this way there is no need for additional psychotherapeutic, hypnotizes the m etc. effects;
- way allows you to adjust the morphological and functional state of organism of athletes as a whole;
the method allows to correct morpho-functional state of sportsmen of various kinds of sports.
The implementation of the invention
The use of the proposed method is carried out in the process of conducting training and competition cycle, aimed at the development of resistance to high and prolonged physical stress, increase efficiency, maintain morphological conditions and physiological functions of the body at the optimum genetically prescribed level. The implementation of the method and the evaluation results of the example.
On the basis of informed consent 15 athletes in rowing accept NCP (main group - experience), and 15 athletes constitute the control group. The age of the comparison group was 16.1±0,4 years (experience) and 16.5±1,0 years (control). Athletes of the main group every day one drink 10.0 g NCP "Antitox and 10 g NCP "Sportaction-2".
Study design: the primary examination intermediate examination (within 15 days of receiving NCP) and 1 month after receiving NCP (final).
The rationale for the composition used NCPRS and NCPPS
Because rowing requires the most physical exertion, the required composition NCP containing animal protein (NCPPS "Sportaction-2").
Physical activity contribute to the violation of antioxidant defenses. In connection with this diet, you must enter NCP with antioxidant properties (NCPRS "Antitox").
NCPRS "Antitox". Composition: klopotoski red grapes, artichokes, beets, parsley.
Red grapes - the richest spectrum of bioflavonoids, polyphenols and proanthocyanidins (anthocyanins, proanthocyanins, anthocyanidins, tannins, catechins, dihydroquercetin, resveratrol etc) enhance detoxification and antioxidant function of cells. Due to high content of vitamins, anthocyanidins, anthocyanins, dihydroquercetin, resveratrol and essential for the metabolism of the human body easily digestible salts of trace elements such as iron, copper, cobalt and zinc, have beneficial effects on all the metabolic processes in the human body, and provide powerful antioxidant protection, regeneration of liver cells, protect cell membranes from destruction under the influence of adverse conditions (infection, radiation, toxicity, elevated oxidative processes), normalize blood pressure, stimulates the activity of the heart muscle and improve processes kravet is rhenium. Polyphenols are one of the most powerful antioxidants found in nature. Their antioxidant activity exceeds the activity of vitamin E is 50 times and vitamin C 20 times. In total red grapes contains not less than 300 compounds with radioprotective, antilocality, antibacterial, antioxidant, neurostimulation, tonic and other functional properties.
The Jerusalem artichoke has strong antioxidant properties and successfully displays the body of the radionuclides, toxins and heavy metals. Dietary fiber and pectin stimulates the contractile ability of the intestinal wall, gently cleanse the intestines. Of Jerusalem artichoke inulin promotes the normalization of the intestinal microflora, the elimination of toxins and improves the functioning of the pancreas. Has a beneficial effect on the cardiovascular system. It is recommended to use for hypertension, atherosclerosis, tachycardia and coronary heart disease. A decoction of the Jerusalem artichoke has a hypoglycemic ability, this is the best treatment for ainsliewood diabetes. Recommended for the treatment of anemia, obesity and arthritis (prevents the deposition of salts, has anti-inflammatory action).
Beets - thanks to the presence of betaine and betanin improves digestion of proteins and is involved in the formation of choline - matter, aviaudio activity of liver cells. Beets also increases peristalsis (due to the presence of fiber and organic acids), thereby facilitating the movement thereon of food, stimulates liver, a diuretic, a light laxative, analgesic and anti-inflammatory, lowers blood pressure. As a vegetable rich in iodine, beets useful in patients with thyrotoxicosis. Active substance beets also stimulate the cleansing of interstitial fluid from toxic substances. Has a tonic effect, stimulates metabolism, increases the hemoglobin content in the blood, improves its structure, etc.
Parsley essential oil (myristicin, limonene, eugenol, alpha-thujone) and flavonoids (apiin, apigenin, luteolin, chrysoeriol) possess diuretic, choleretic, spasmolytic effects and detrimental effect on pathogens. Parsley has a positive effect on oxygen exchange and maintains the normal functioning of the brain, adrenal and thyroid glands. Due to the high content of vitamin C, a powerful antioxidant protector of the body from free radicals, vitamin C helps to prevent the development and progression of atherosclerosis, diabetes, asthma, needed by the body for healthy functioning of the immune system. Beta-carotene is converted in the organisme in vitamin a, normalizes the function of the immune system. Parsley is rich in vitamins b, PP, and K, contains many minerals and trace elements necessary for human body, iron, phosphorus, zinc, calcium, magnesium.
NCPPS "Sportaction-2". Composition: klopotoski rabbit meat, celery, onion, pumpkin, rose hips.
Rabbit meat contains all the essential amino acids required for the human body; absorbed 90%; Allergy-tested. In the vitamin and mineral composition of rabbit meat is superior to all other species and contains vitamin B1B2In3In5B6B9In12and minerals (per 100 g of product) - potassium (239 mg), calcium (13 mg), magnesium (19 mg), sodium (41 mg), phosphorus (213 mg), iron (1,57 mg). Rabbit meat is an ideal diet product contains almost no cholesterol, that is a good prevention of arteriosclerosis; able to normalize fat metabolism, has a beneficial effect on the digestive tract, stimulating the secretion and restoring the normal functioning of the entire digestive system. A good antioxidant, enhances DNA synthesis and myelin. When acute or chronic hypoxia increases consumption in the cells of oxygen.
Celery stimulates the production of androgen (male sex hormone), resulting in increases in muscle mass.
Essential oil of villages who Dere simultaneously and provides a calming, and tonic effect on the Central nervous system. B vitamins also help to improve the functioning of the nervous system.
Onions have high levels of zinc, which promotes effective increase muscle mass and strengthen the immune system.
Pumpkin has a high sorption activity against cholesterol, toxins, harmful metabolic waste products and salts of heavy metals, activates the detoxification function of the liver and contributes to the restoration of hepatocytes, normalizes the function of the biliary tract. Beta krotin promotes antioxidant protection of the organism.
Rose - contains vitamins C, E, P, carotenoids and bioflavonoids, which help increase the body's defenses, possess a strong antioxidant effect. Magnesium salts cause a choleretic effect of rosehip and its beneficial effects on the cardiovascular system.
All of the subject was made a General analysis of the blood on generalizatio "Hemalux 19". We investigated the main indicators of the blood, the hemoglobin concentration, the number of erythrocytes, the average amount of hemoglobin in the erythrocyte, the average volume of erythrocytes, color index, the content of iron in the serum, hematocrit, white blood cell count. Laboratory studies were performed the ü certified and standardized methods.
Biochemical research methods
Indicators of carbohydrate metabolism
To determine the concentration of glucose in blood serum was used glucoseoxidase method Trinder (TrinderP., 1969). Used set of reagents company "olivex diagnosticum".
The level of lactate in blood plasma were determined by enzymatic colorimetric method using lactate dehydrogenase using a set of reagents "Lactat FS" company "Dia Sys Diagnostic Systems GmbH, Germany.
Determined total cholesterol (LDL), cholesterol, low-density lipoprotein (LDL-C), cholesterol high density lipoprotein (HDL-C), triglycerides (TG). Were used kits company "olivex diagnosticum". Total cholesterol and triglycerides were determined by enzymatic colorimetric method Trinder to determine LDL-C and HDL-C were used precipitating reagent with subsequent determination of total cholesterol.
Indicators of protein metabolism
The concentration of uric acid was determined by enzymatic colorimetric method without deproteinization, creatinine - pseudoceramides method based on the Jaffe reaction without deproteinization. Total protein in serum was determined by biuret method (Weichelbaum IE, 1946). To determine these parameters were used kits company "olivex diagnosticum".
It is ncentratio myoglobin, troponin 1, ferritin, erythropoietin and C-reactive protein in the serum was determined by enzyme-linked immunosorbent assay using a reagent kit for the company "Vector-best". For the study of C-reactive protein used set of "SLO-ELISA - the BEST (highly sensitive)".
The activity of alanine aminotransferase (Alat), aspartate aminotransferase (AST) were determined by enzymatic kinetic method using a reagent kit for the firm "DEACON-DS". The activity of lactate dehydrogenase (LDH), MB fraction of creatine kinase (ck-MB) - kinetic UV method using a reagent kit for the company "Vector-best".
Indicators of hormonal status
To evaluate hormonal status in the serum was determined by the content of cortisol and insulin enzyme-linked immunosorbent assay using a reagent kit for the company "Vector-best" and "Accu-Bind ELISA Microwells INSULIN" BY Monobind Inc., USA.
Indices of antioxidant system
To assess the state of the antioxidant system in blood serum were used to define the total antioxidative and oxidative status using a set of reagents "Im AnOx (TAS/TAC) Kit", "Per Ox (TOS/TOC) Kit" company "Immundiagnostik Germany.
Evaluation of humoral immunity
To assess humoral immunity in serum was conducted studies globulin fractions - gG, IgA by ELISA using kits company "Vector-best".
Determination of trace elements in blood serum
For the determination of trace elements in blood serum were used kits company "olivex diagnosticum".
Inorganic phosphorus in the serum was determined by a spectrophotometric method without deproteinization. Sodium concentration was determined by colorimetric method using a precipitating reagent.
The chloride concentration was determined by colorimetric method using thiocyanate mercury.
Sanitary-chemical methods of research
Assessment of vitamin saturation of the body (vitamins a, E, B1and B2 in the blood) was performed on the analyzer bioliquids "Fluorat-02-ABLF-T - luminescent-photometric.
Determination of trace elements (zinc, copper, iron) in serum was performed using atomic absorption spectrometer "quantum-2A" with a fiery way atomization of the sample and the deuterium background corrector.
Estimated indicators of physical health: forces leading brush and indicators exercise load.
Statistical data processing was carried out using the software package Statistica 6,0.
The results of the study on the impact of NCPPS and NCPPS on morphofunctional status is e athletes
Before you start taking NCPPS and NCPPS in athletes rowing - 22,2% was excessive MT and at 5.6%, which is lower MT.
The content of vitamin B1in the serum of all athletes was reduced. The saturation of the body with vitamin a of 10.0% was reduced from 10.0% level was at the lower limit of normal. The content of vitamin E was reduced from 40.0% of athletes rowing. However, 13.3% of the body saturation was reached just by 60.0% (45,0-68,8%) from the norm. The saturation of the body with vitamin b3was reduced in 43,3% and the maximum reduction from the level of the standards reached 2.5 times.
The copper content in the serum was normal only 70,0%. The rest of the copper deficiency has reached 21.4 per cent.
Biochemical indices in 20-30% of the surveyed persons identified exceeding the upper limit of normal creatine kinase-MB, asparaginases and lactate dehydrogenase, indicating that the voltage of the activity of cardiac muscle.
On the negative changes in the antioxidant protection of the organism testified excess at 46.7% of the content of malondialdehyde, catalase activity - of 20.0%, 20.0% by concentrations of metabolites of nitrogen.
In the evaluation of carbohydrate metabolism is determined that the glucose concentration was above or within the upper limits of the rate of from about 30.0%, the concentration of cortisol was approaching the upper limit of p is parentage values, 16.7% was exceeded by 5-13% of the upper boundary of the acceptable level, i.e. to 46.7% of the athletes were in a state of tension and stress. The concentration of lactic acid in half of the surveyed persons in 10-60% was above the upper limit of the reference values of them at 53.3%-1.5-2.0 times.
At the first examination of athletes in almost all subjects of the experimental and control groups the concentration of cortisol was approaching the upper limit of reference values, and 3 athletes experimental and 2 control groups the concentration of cortisol exceeded 5,0-13,0% the upper limit of the allowable level. These data suggested that the athletes in training and competition period was in a state of prestress and stress.
The analysis of the dynamics of the concentration of lactic acid showed that half of the respondents the level exceeded for 10-60% of the upper limit of the reference values. In individuals, the concentration of lactate was achieved 32-36 µmol/l, that is 2 times the upper limit of normal. In 9 subjects of the experimental and 7 control group, there was an increase in serum lactic acid to 22.4±4,8, 21,2±7,3 mmol/L.
Evaluating the performance of erythropoiesis, the athletes noted a decrease in the level of iron in 36.7% of patients. They noted decreased levels of erythropoietin and ferritin. The obtained data suggested the presence of STRs is Tsenov placentero and latent iron-deficient erythropoiesis.
At 20.0% of the athletes were revealed increased values of total cholesterol, in 6.7%-LDL.
23.3% of the surveyed identified an increased level of C - reactive protein, indicating the presence of inflammatory processes.
The level of immunoglobulin G was above the upper border of 10-12%and 50,0% of them - 42.9-59,4%.
At the end of the reception NCP "Antitox and Sportaction-2" (despite intensive training and participation during the 2 days before the examination in the qualifying competition) reliable dynamics is defined by the following parameters of the body:
Indicators of vitamin a saturation of an organism
1. The increase in the serum concentration of vitamin a by 40.0%. The maximum increase is determined in individuals for whom initially, this level was below normal or within the lower limit of normal - 4.3-2.3 times.
By the end of the observation level of vitamin a in the serum of the main group was significantly higher than that in the initial state, 27.7%.
In the control group, a positive dynamics in the observation period is not defined.
2. Of 68.7% increase in the concentration of vitamin E1; the maximum increase in the concentration of vitamin E was reached 4.2 times. By the end of the study, the concentration of vitamin B1increased 26.4%. Positive dynamics in the control group is not defined.
Indicators of the mineral is Noah saturation of an organism
Increased levels of iron 23.2-42,2% (in the control group did not change). Important was the fact that after the event in the control group it was observed a significant decrease in the level of potassium (20.4%), calcium (5.2%), sodium (11.0%) and chloride (22.3%). In the experimental group reduce the level of these minerals have not been identified.
Indicators of the state of the cardiovascular system (CVS)
There was a positive dynamics in athletes, characterizing the state of the CAS. The positive dynamics was noted in the average value of the indicators, and the frequency of their deviations from the reference values. After taking NCPP in the experimental group decreased activity asparaginases (AST), creatine kinase MB fraction (ck-MB) and lactate dehydrogenase (LDH), respectively 1.5 times, while in the control group, the activity of these enzymes was kept at the same level. 10 times the subjects of the experimental group decreased the concentration of troponin 1, whereas in the control it only went down 3 times.
By the end of the observation level of AST in the control group increased in individuals of the group experience was within the reference limits.
Indices of antioxidant status
All subjects of the experimental group with a high content of malondialdehyde were identified its significant reduction, reduction the act is vnesti catalase.
In the recovery period showed a significant decrease in the level of malonic aldehyde in individuals of the main group of control changes were observed. While the athletes of the main group twice (in comparison with the previous study) decreased the proportion of those with level of malonic aldehyde, exceeding the upper limit of normal; in the control group it is 17.9% higher than in the main group.
Indicators of carbohydrate metabolism and euroamericana
Persons main group normalization of glucose levels. Increased levels of the hormone insulin after administration NCP on the background of normal glucose testified stimulation of anabolic processes in the body.
Indicators of erythropoiesis
After applying NCP increased iron concentration in the serum level of erythropoietin and ferritin in the experimental group. In the control group had a significant decrease in the level of ferritin (rising phenomena of iron deficiency anemia).
By the end of the observation period in the control group has doubled the proportion of individuals with iron levels below the norm.
Indicators of protein metabolism
In the experimental group after receiving NCPP an increase in the fraction α1-globulin (29,0%) and the fraction of γ-globulin (13.3%), which persisted until the end of the observation period. In the control GRU is PE change in the ratio of protein fractions was observed.
In the experimental group decreased cholesterol (LDL) by 10.8%, cholesterol of low-density lipoprotein (LDL-C) - 30.9%, triglycerides (TG) had a tendency to decrease. In the control group the values of cholesterol and LDL-C remained at the same level, and TG increased in 1.7 times.
Indicators reflecting the state of the liver, kidneys
Changes in the activity of enzymes Alt and GGT, reflecting the state of the liver, was not identified. In the experimental group did not show any deviations in the content of urea and creatinine, indicating the normal functioning of the kidneys. In the control group revealed a slight but significant increase relatively experienced group of urea.
Indicators of humoral immunity
There is a tendency to normalization of the levels of immunoglobulin G, the concentration of immunoglobulin a is normalized. In the control group showed a clear reduction in all fractions of immunoglobulins G and A - to the lower limit of normal, suggesting a clear trend to immunodeficiency.
Autonomic nervous system
In athletes of the main group were found significant changes in percentages in the direction of increasing the contribution of HF and reduced percentage contribution of power very low frequency (VLF), which can be seen as put the function dynamic shift of activity towards the parasympathetic division of the autonomic regulation of the heart rate in these athletes.
When conducting psychophysiological testing installed more pronounced increase in the rate of simple visual-motor reaction in a group experience compared to the control group.
Indicators of physical health
1. In evaluating the performance of forces leading brush in athletes, their increase in individuals of the control group by the end of the observation was not determined. The athletes of the group experience is defined as the increase in the strength of the leading brush 9.0%; it increased to 50.0% of patients.
2. In athletes of the experimental group was significantly more increased power exercise work in the control and tended to decrease. While the subjects of the experimental group HR urials, in control - remained unchanged. The increase in maximal oxygen consumption testified to more efficient energy demands of athletes group experience on muscular work. The sportsmen group experience did more load with less effort in the control group, on the contrary. This proves more significant increase in performance in subjects of group experience. During the reception NCPP all athletes noted more easy portability loads and recovery, improvement of health.
Summarizing the research, the following can be stated:
- athletes rowing in radiorefrakternae and competitive periods identified expressed in varying degrees: lack of vitamin a security body; reduced levels of copper in serum (deficit affects the blood, the absorption of iron, the condition of the connective tissue, the processes of myelination in the nervous system, increases the predisposition to cardiomyopathy and others ); presence of signs of iron deficiency erythropoiesis; the voltage of the cardiovascular system; violation of antioxidant protection and humoral immunity; the presence of inflammatory processes in the body; "voltage" carbohydrate and lipid metabolism, signs of hypoxemia. State "voltage (the level of the hormone cortisol in the body is defined at 100.0% of athletes; in the study of blood serum after the competition had a significantly lower level of potassium, sodium, chloride and calcium in individuals of the control group, indicating that the disturbance of the electrolyte balance of the body;
- when included in the diet of athletes in rowing two NCPP: NCPRS "Antitox" and NCPPS "Sportaction-2" is defined accurate dynamics on growth of vitamin sufficiency of the organism (100.0% level of vitamin E in normal B2- 26.4%); increase iron levels to 42.2%, erythropoietin level and ferritin (leveling characteristics predlojennoi anemia); positive dynamics in the function of the CCC, carbohydrate, lipid metabolism, autonomic the nervous system and physiological indicators; normalization of antioxidant protection of the body and stimulation of humoral immunity, decrease inflammation, normalization of electrolyte balance.
The above results confirm the relevance of the presented correction method of the functional state of athletes and efficiency NCP.
Inclusion in the diet of athletes NCP restores metabolic processes of the body that is in normalizing its functions and increase efficiency. Against this background, perhaps other methods of correction of functional state of athletes.
Sources of information
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1. Method of correction of the functional state of athletes, namely, that in the diet include multicomponent natural concentrated foods (NCP) with high content of biologically active substances (BAS) of the plant (NCPRS) and (or) protein and vegetable raw materials (NCPPS), taking into account the objectives nutriention support of athletes of different sports, their individual physiological needs; the consequence of which is to restore the totality of characteristics, physiological functions and qualities that determine the level of activity of functional systems of the body, especially the activity and status of occupational health and ensuring the prevention of psycho-physiological and pathological conditions, the achievement of high sports results.
2. The method according to claim 1, characterized in that the correction of the functional state of athletes use only NCPP from plant and (or) protein-vegetable raw materials with a high content of biologically active substances, including minor components manufactured by cryogenic technology; and exclude the use of any pharmacological agents and flavoring additives.
3. The method according to claim 1, characterized in that Thu is for the correction of the functional state of athletes in this way eliminates additional psychotherapeutic, hypnotic effects.
4. The method according to claim 1, characterized in that allows you to simultaneously adjust the morphological and functional state of organism of athletes in General.
5. The method according to claim 1, characterized in that allows you to adjust the morphological and functional state of athletes of different sports.
SUBSTANCE: method involves preliminary intraperitoneal single administration of 5% aqueous alloxan in a dose of 15 mg/kg of body weight into a rat's body on an empty stomach. That is followed by administering afobazol under conditions of oxidative stress after observing the rat's blood glucose gain at least twice. Afobazol is administered subcutaneously in a dose of 10 mg/kg of body weight once a day for 30 days with underlying administration of L-arginine in a dose of 10 mg/kg of body weight or with underlying NG-nitroarginine methyl ester (L-NAME)-inhibitor of NOS-3 enzyme in a dose of 25 mg/kg of animal's weight.
EFFECT: method enables correcting the oxidative stress and NO-producing endothelial dysfunction accompanying vascular complications of diabetes mellitus.
1 dwg, 6 tbl, 1 ex
SUBSTANCE: invention refers to medicine, namely to rehabilitation medicine and concerns prevention of meteopathic reactions. That is ensured by administering an adaptogene agent presented by a phytococktail containing mixed 70% tinctures of eleuterococcus, common licorice and rhodiola rosea in the ratio of 2:1:1. The cocktail is introduced in a dose of 10-15 drops for two weeks once a day, taking into account an individual's chronotype. That is followed by a magnetic-infrared-laser exposure covering the acupuncture points Tr(X)5 - Wai Guan, E(III)36 - Zuo San Li, Tr(X)15 - Tian Liao and MC(IX)5 - Jian Shi through an applicator wetted in the phytococktail containing 70% alcoholates of rhodiola rosea, common licorice, yellow starwort and spiny eleuterococcus in the ratio of 2:2:1:1, in a combination with an aromatherapy with Atlas cedar oil.
EFFECT: integrated exposure in the developed mode provides higher non-specific body resistance to meteorological factors.
2 ex, 3 tbl, 8 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: there are presented: using a compound of formula (1) or its salt for preparing a drug for increasing HIF-1α stabilisation in a cell, as well as for preparing a drug enhancing the immune response in an individual, for preventive management of a wound to avoid an infection, for treatment of the microbial infection, for improvement of efficacy of a vaccine for management of the wound in the individual. What is presented is a pharmaceutical composition containing the above HIF-1α prolyl hydroxylase inhibitor and one or more additives. What is shown is achieving the declared applications by using the new compound of formula (1) with the HIF-1α prolyl hydroxylase (HIFPH2 (EGLN1)) inhibitor. It makes it applicable for treating HIF-1 alpha activity related diseases, conditions and/or syndromes.
EFFECT: preparing the drug for increasing HIF-1α stabilisation in a cell.
26 cl, 20 dwg, 8 tbl, 13 ex
SUBSTANCE: what is used is a 20% alcoholic tincture (1:10) of medicinal herbs in the following weight proportions: Rhaponticum carthamoides roots and rhizomes - 2, tormentil roots - 1, peppermint leaves - 3. A mouthwash is prescribed before a dentist's appointment for 3-4 days 3 times a day, as well as 10-15 minutes before an impression manipulation.
EFFECT: method provides reducing intensity a gag reflex accompanying dental manipulations.
SUBSTANCE: what is presented is a method for stimulating the post-traumatic spinal cord regeneration consisting in a single-stage transplantation of human umbilical cord blood mononuclear cells pre-transduced with recombinant adenovirus with a cloned gene of glial derived neurotrophic factor (gdnf), in the damage area.
EFFECT: using the invention enables providing a better outcome of the post-traumatic spinal cord regeneration, reduced length of staying in hospital of patients suffering from a spinal cord injury and improving the patients' quality of life.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to the pharmaceutical industry, particularly to a pharmaceutical composition for dehydration, atrophy and removal of abnormal tissues, and to using it. The pharmaceutical composition for dehydration, atrophy and removal of abnormal tissues contains a composite of an inorganic polymer iron salt as an active ingredient; the composite of the inorganic polymer iron salt is polymer ferrous sulphate silicate (PFSS), or polyferrous silicate chloride (PFSC), or polyphosphate ferrous sulphate (PPFS). Using the pharmaceutical composition consists in preparing the drug for dehydration, atrophy and removal of abnormal tissues.
EFFECT: pharmaceutical composition is effective for dehydration, atrophy and removal of abnormal tissues in treating haemorrhoids, haemangiomas, varicose veins, burns, bleeding traumatic wounds, local wounds caused by chemicals or microorganisms.
9 cl, 12 dwg, 2 tbl, 7 ex
SUBSTANCE: group of inventions relates to medicine and can be used for modification of eating behaviour in a subject. For this purpose peripheral introduction of PYY in an amount, efficient for achieving physiological levels of PYY3-36 in blood, plasma and serum, determined after food intake, is performed; or performed is peripheral introduction of PYY agonist in an amount, efficient for imitation of physiological levels of PYY3-36 in blood, plasma or serum, determined after food intake with modification of eating behaviour, by reducing intake of calories, food consumption or appetite reduction or increase of energy consumption in the subject. Also claimed is application of PYY or its agonist as an active ingredient in production of medication.
EFFECT: group of inventions provides weight reduction in the subject due to reduction of intake of calories, appetite reduction or increase of energy consumption in the subject.
50 cl, 9 dwg, 6 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to chemical-pharmaceutical industry and represents a preparation for involving a mesenchymal stem cell of the bone marrow into peripheral blood from the bone marrow, which is introduced into the blood vessel or muscle and which contains any of components: (a) protein HMGB1; (b) HMGB1 protein-secreting cell; (c) a vector, into which HMGB1 protein-coding DNA is inserted; (d) protein HMGB2; (e) HMGB2 protein-secreting cell; (f) a vector, into which HMGB2 protein-coding DNA is inserted; (g) protein HMGB3; (h) HMGB3 protein-secreting cell; and (i) a vector, into which HMGB3 protein-coding DNA is inserted.
EFFECT: elaboration of the preparation for involving the mesenchymal stem cell of the bone marrow into peripheral blood from the bone marrow.
3 cl, 6 ex, 1 tbl, 14 dwg
SUBSTANCE: invention refers to medicine, namely immunology, and may be used for reducing eosinophil count in a human body. That is ensured by the parenteral administration of approximately 0.01 mg/kg to approximately 0.25 mg/kg of a monoclonal chimeric humanised antibody or a human antibody which binds to IL-5P and contains an immunoglobulin Fc fragment and is fucose-free; the administered antibody reduces the peripheral blood circulating eosinophil count below the detection threshold, and the circulating eosinophil calculation level remains below the detection threshold for approximately 28 days after antibody dosing.
EFFECT: using the given method leads to fast and prolonged reduction of peripheral blood eosinophils.
9 cl, 14 ex, 31 dwg, 1 tbl
FIELD: chemistry, pharmacology.
SUBSTANCE: invention relates to field of pharmacology and medicine and deals with application of halogenides of 1,3-disubstituted 2-aminobenzimidazolium, of general formula I as inhibitors of Na+/H+-exchange, as well as novel 1,3-disubstituted halogenides of 2- aminobenzimidazolium.
EFFECT: increased efficiency of inhibitors.
3 cl, 1 tbl, 2 ex
SUBSTANCE: group of inventions refers to medicine, particularly to an advanced increase of nicotine concentrations in a gas carrier. The method aims at nicotine delivery for the therapeutic action at various diseases, particularly for stopping, substituting and/or reducing a damage of consuming tobacco products. Besides, the group of inventions refers to various devices and design principles of the device for practical application of the given method.
EFFECT: group of inventions enables preparing the aerosol for pulmonary delivery without the need of excipients and other additives, including solvents.
46 cl, 18 tbl, 16 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: there are offered: using an agent improving absorption and containing an ester of fatty hydroxy acid and polyethylene glycol 660 (particularly Solutol® HS15) as a part of a pharmaceutical composition as the agent improving absorption of the therapeutic agent through a mucous membrane, wherein the therapeutic agent has the value log P less than approximately 1 and (a) represents a peptide, a protein, a nucleic acid, an antigen or a vaccine; and/or (b) is other than a P-glycoprotein (P-Gp) substrate. The pharmaceutical composition of the above substances (versions), a method for preparing it and a method for administering, and using the ester of fatty hydroxy acid and polyethylene glycol 660 for preparing the above therapeutic agent are also presented.
EFFECT: higher insulin absorption from the declared agent vs absorption thereof from a formulation with PEG and PEG-hydroxystearic acid has been shown, with Solutol® HS15 having the slight effect on opening the tight contacts of epithelial cells.
35 cl, 8 dwg, 9 ex
FIELD: chemistry, pharmacology.
SUBSTANCE: pharmacological composition for preparing drug forms in form of powder, solution or bandage consists of biocompatible film-generating polymer polyvinylpyrrolidone (Mm 20000), iodine and Novocain, taken in quantities, given in the invention formula. Pharmaceutical composition is intended for processing wound surface and treatment of burns. Composition possesses antiseptic, local anesthetic and wound-healing action.
EFFECT: water-soluble form of medication possesses high anti-burn activity, low cost and long storage term.
FIELD: medicine, pharmaceutics.
SUBSTANCE: there are presented: a composition for treating cancer containing (a) a conjugate containing (i) a polypeptide vector containing an amino acid sequence min. 70% identical to AngioPep-2 (SEQ ID NO: 97); and (ii) paclitaxel or a paclitaxel analogue conjugated with the above polypeptide; (b) an optional tonicity agent; (c) a buffer agent; (d) an excipient; (e) a polyoxyethylene ester of fatty acid; and (f) 0.01-8% DMSO (versions), a method for preparing (versions), a method of treating cancer, a container comprising the above composition, and a kit comprising the container with the above composition.
EFFECT: invention differs by the fact that the declared conjugates (eg ANG 1005) may pass through the hematoencephalic barrier, be characterised by high absorption by the targeted cells, manifest higher stability or be removed from the cell in a lesser degree, while the based compositions may be dissolved in an aqueous solution; they differ by stability and the minimal decomposition at temperatures within the range of 40°C and 50°C.
53 cl, 3 dwg, 28 tbl
SUBSTANCE: present invention relates to a method of increasing water solubility of a low-solubility substance used in pharmaceutical products, veterinary pharmaceutical products, cosmeceuticals, cosmetic products, food products, agricultural chemicals etc. The method of increasing water solubility involves depositing a coating of microparticles of a low-solubility calcium compound, e.g. calcium phosphate or calcium carbonate, on the surface of particles of a low-solubility substance using mechanical energy to allow microparticles of the low-solubility calcium compound to penetrate particles of the low-solubility substance used in pharmaceutical products, veterinary pharmaceutical products, cosmeceuticals, cosmetic products, food products, agricultural chemicals etc.
EFFECT: high water solubility of the low-solubility substance.
14 cl, 99 tbl, 8 ex, 20 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed is application of preparation DAM+™ for injection treatment of gastroesophageal reflux (gastroesophageal reflux disease).
EFFECT: described is recovery of locking function of gastroesophageal junction with absence of migration, which contributes to extension of arsenal of medications used for treatment of the disease.
5 dwg, 1 tbl
SUBSTANCE: invention relates to chemical-pharmaceutical and food industry and specifically to production of powdered and encapsulated forms of preparations, having antihypoxic and antioxidant action. The molecular complexes are capable of solubilisation in water and are more stable (protected from oxidation) compared to water-insoluble and rapidly oxidisable free reduced coenzyme Q10. Also disclosed is a method of producing said substance, which contains "reduced coenzyme Q10 - β-cyclodextrin" complexes, which comprises consecutive steps of (i) obtaining a reduced form of coenzyme Q10 in the presence of excess ascorbic acid; (ii) mixing the reaction solution obtained at step (i) with aqueous solution of β-cyclodextrin to obtain molecular inclusion complexes; (iii) cooling and crystallising the mixture obtained at step (ii) and removing solvent and water.
EFFECT: substance obtained according to the present invention is a biologically active powdered form of sufficiently stable molecular inclusion complexes of the reduced coenzyme Q10 in β-cyclodextrin with particle size of up to 70-100 mcm, which is tenfold less capable of oxidation compared to free reduced coenzyme Q10 and is easily transferred in an aqueous solution into a solubilised form with particle size of 200-700 nm.
15 cl, 5 ex
SUBSTANCE: present invention refers to fumaryldiketopiperazine (FDKP) microparticles applicable for pulmonary delivery and having a specific surface area within the range of 15 m2/g to 67 m2/g and a diameter within the range of 0.5 mcm to 10 mcm. The invention also refers to a dry powder comprising said microparticles that is also applicable for pulmonary delivery, to an inhalation system comprising a powder inhalation apparatus and the above dry powder, as well as to a method for delivering an active agent being an ingredient of the dry powder by inhalation of the above dry powder. There are also disclosed methods for forming the FDKP microparticles, first of which comprises dissolving FDKP in aqueous ammonia, adding an acidic solution to aqueous ammonia at temperature up to 12°C to 26°C and collecting a precipitate containing the FDKP microparticles after rinsing with deionised water. A second method for forming the FDKP microparticles involves supplying equal portions of 10.5 wt % of an acetic acid solution and 2.5 wt % of a FDKP solution at temperature 14-18°C through a high-shear mixer.
EFFECT: invention aims at preparing the FDKP microparticles applicable for pulmonary delivery that have the good aerodynamic performance and provide the enhanced drug absorption.
18 cl, 4 tbl, 9 dwg, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to chemical-pharmaceutical industry, particularly to a method for preparing a powder. The method involves the stages of providing at least one first ingredient that has a consistence of viscous fluid and that has an initial melting point within the temperature range of 15°C to 40°C, providing at least one second ingredient that has a melting point, particularly within the range above an ambient temperature up to 120°C, preparing a homogenous liquid mixture containing one first ingredient and one second ingredient by mixing and heating the mixture to a temperature or maintaining a temperature of the mixture within the range above the melting point. Supplying the liquid mixture to an irrigation hardening unit and extracting the powder prepared by irrigation hardening. In addition, the present invention refers to the method for preparing the solid dosage form containing the powder prepared by the method described above.
EFFECT: improvement of the method.
17 cl, 6 ex, 2 tbl
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, namely a method for preparing a biologically active complex containing serotonin. The method for preparing the biologically active complex containing serotonin involves milling a herbal raw material that is young sprouts of sea buckthorn collected in the early spring and containing 0.9%-1.1% of serotonin in a cutting mill; mixing the milled herbal raw material and ascorbic acid in a blade mixer; carrying out solid-phase mechanochemical treatment in a roll mill in the intensive mechanical environment in the presence of solid edible agents specified in: citric acid - sodium chloride at a dry substance (1:0.5)-(1:1), or acid, alkaline and phosphate-containing agents to prepare a fine powder at particle size 125 mcm.
EFFECT: ensured simplifying the technology, improving the production rate, as well as higher yield of the end product per a unit of raw material, and providing the chemical production safety.
5 cl, 1 dwg, 5 tbl
SUBSTANCE: agent contains three active substances: polyhexamethylene guanidine hydrochloride, alkyldimethylbenzylammonium chloride and N,N-bis(3-aminopropyl)dodecylamine. The agent also contains liposentol hydro, lactic acid, a fragrance and water, with a defined amount of components in wt %.
EFFECT: agent has a wide range of disinfecting action, low toxicity and negative effect on skin.
3 tbl, 1 ex