Method for endoscopic bioplasty of gastroduodenal ulcers with complex bioplastic material
SUBSTANCE: what is performed is an endoscopic approach; further, biopsy forceps with a rolled complex bioplastic material cut in size of an ulcerous defect are introduced into a working path of a fibrogastroduodenoscope, laid on the ulcerous defect with the use of the biopsy forceps, and controlled with the use of an endoscopic examination 5-7 days later. The bioplastic material contains hyaluronic acid, a phosphate buffer system, omeprazole and clarithromycin taken in a certain equivalence ratio.
EFFECT: non-invasive treatment of ulcer and reduced length of mucosal tissue regeneration.
1 tbl, 2 ex
The invention relates to medicine, namely to abdominal surgery, gastroenterology, and may find application in the treatment of gastroduodenal ulcers.
Currently, modern trends in the treatment of gastric ulcer is aimed at developing methods, replacement surgical treatment is the creation of new drugs and new technologies for minimally invasive endoscopic techniques. Medical treatment of peptic ulcer includes two major pharmaceutical group - blockers, antacids and gastric secretion.
Antacids neutralize the hydrochloric acid that is part of the gastric juice. These drugs contain magnesium, aluminum, calcium, and combinations thereof. Secretomotor depressing effect on the mechanisms of secretion of hydrochloric acid. Among antiulcer drugs are blockers of N2-histamine receptors, prostaglandins, proton pump inhibitors.
Recently against peptic ulcer began to use antibiotics to get rid of its main causes - the bacteria Helicobacter pylori. Second, the Maastricht Treaty puts on the first place among the indications for antihelicobacter therapy of gastric ulcer and peptic ulcer disease duodenal ulcer, regardless of the phase of the disease (about ostrinia or remission), including their complicated forms (Malfertheiner p, Megraud F., S.' Morain et al. Current concepts in the management of Helicobacter pylori infection-the Maastricht 22000 Consensus Report. // Aliment oil displayed pure. Pharmacol. Ther. 2002. V.16. R). Stressed that eradication therapy for peptic ulcer disease is a medical event, and the validity of its use in this disease is based on the obvious scientific facts.
Drug treatment of peptic ulcer disease has a limitation related to the systemic effects of drugs on the body that is accompanied by the appearance of side effects, so the priority is the application of methods and means acting locally on the ulcerative process of the gastric mucosa. In this direction the most appropriate and promising is the use of endoscopic techniques in combination with the local drug action, i.e. delivery of drugs in the seat of the disease in the stomach (duodenum).
There is a method of endoscopic injections of the gastric mucosa drug (Patent RF №2179858, A61K 38/02, A61P 1/04). Spend transendoscopic around the ulcer drug splendid. Drug dose 115-230 mg diluted in 10 ml of 0.25%solution of novocaine or saline and inject 2-3 ml into three points on the edges of the ulcer into the submucosal layer. Treatment including the background of traditional protivoyazvennami, including H2blockers of histamine and H. pylori funds. Procedures injections conducted at intervals of 2-3 days, the number of treatments 4-6. The method provides a reduction of possible scarring ulcers.
The disadvantage of this method is the inability of long-term preservation of the drug at the disease site that requires frequent (4-6 per treatment). Manipulation invasive, possible complications, such as bleeding from the injection site. It should be noted that it is unpleasant and painful procedure.
The technical result of the proposed method endoscopic bioplastics gastroduodenal ulcers complex bioplastic material is minimally invasive (non-surgical) treatment of ulcers and reduction of tissue regeneration of the mucous membrane of the body.
The task is solved in that in the method of endoscopic bioplastics gastroduodenal ulcers complex bioplastic material, including endoscopic access to the working channel fibrogastroduodenoscopy enter biopsy forceps with rolled-integrated bioplastic material, cut to the size of the ulcer, stack on ulcerative defect using biopsy forceps, and control is carried out by endoscopic examination after 5-7 days, with bioplastic material contains hialuronowy acid, phosphate buffer system, omeprazole and clarithromycin in the following ratio, wt.%:
|phosphate buffer system||5|
Phosphate buffer system provides the neutralization of the excess of hydrochloric acid and protects the underlying mucosa of the stomach from the corrosive effect of gastric juice.
Bioplastic material contains in its structure omeprazole, which inhibits the enzyme H+- +-ATPase ("proton pump") in the parietal cells of the stomach and blocks thereby the final stage of the synthesis of hydrochloric acid. This leads to reduced levels of basal and stimulated secretion, irrespective of the nature of the stimulus.
In addition, the composition of bioplastic material included clarithromycin, which has bactericidal activity against Helicobacter pylori, recognized by many researchers as a cause of the development of peptic ulcer. Clarithromycin, unlike most antibiotics, macrolides, is not subject to hydrolysis and is of Stoychev to the action of hydrochloric acid [Lapina TL, Ivashkin V.T. Modern approaches to the treatment of gastric ulcer and duodenal ulcer // Russian medical journal. - V.3, №1, 2001. - 10-15; Lapin TL Modern approaches to the treatment of acid-N. pylori-associated diseases // prospects of Clinical gastroenterology, Hepatology. 1, 2001. - 21-27].
Thus, for a new method of endoscopic bioplastics gastroduodenal ulcers is complex bioplastic material having the composition shown in the table.
|Component||Quantitative measure%||The function of the component|
|Hyaluronic acid||90||Matrix-carrier for Pharm. drugs effective regenerant. Provides adhesion (sticking) to the gastric mucosa and prolonged biodegradation (14 day)|
|Phosphate buffer system||5||Neutralization and protection from irritation of excess hydrochloric acid in the area of the ulcer|
|Omeprazole||2||Neutralization and protection from irritating dei is the conduct of excess hydrochloric acid in the area of the ulcer|
|Clarithromycin||3||Bactericidal activity against Helicobacter pylori|
Thanks to an extensive network of macromolecules of hyaluronic acid polymer capable of retaining the structure of the above components in an inert chemical status. Methods of analytical chemistry has been proven that in the polymeric matrix of hyaluronic acid does not occur chemical reactions, and omeprazole and clarithromycin remain chemically stable.
To date in the medical literature do not describe the methods endoscopic application of bioplastic materials in gastroduodenal ulcers, because not developed a comprehensive biomaterials with acid resistance, adhesion to the mucous membrane of the stomach and the long-term ability to remain in the area of the ulcer until full healing effect depo drug for omeprazole and clarithromycin.
Principal scientific innovation in the proposed method, the endoscopic bioplastics is integrated bioplastic material in endoscopic techniques in the treatment of gastroduodenal ulcers. Properties acid resistance and adhesion to the biomaterial to the mucosa allows the biomaterial long to be in the blast ulcer effect of its rapid regeneration.
In fact, there is an innovative solution to use complex bioplastic materials that provide a local therapeutic effect due to the presence in the composition of omeprazole and clarithromycin. It provides a prolonged effect of drugs and faster healing gastroduodenal ulcers, which ultimately prevents surgical treatment and significantly (60%) reduces the time of the patient's stay in hospital.
The method is as follows.
First, for a method of endoscopic bioplastics gastroduodenal ulcers is preparing a comprehensive bioplastic material as follows.
1. Prescription number of crystalline powder hyaluronic acid is diluted in 100 ml of distilled water, get viscous hydrocolloid, which is within 3 hours subjected to standard drying with an elastic film 100 sq., see (10×10 cm).
2. In 10 ml of phosphate buffer system is added to the prescription amount of omeprazole and clarithromycin, mix thoroughly.
3. The resulting mixture was poured into a flat glass dish, there is placed an elastic film of the polymer of hyaluronic acid, allowed to stand for 1 hour.
4. After one hour, the film completely absorbs 10 ml of a mixture of omeprazole, clarithromycin, and phosphate buffer systems. Comprehensive bioplastic material article which becomes ready for use.
Then in the working channel of fibrogastroduodenoscopy enter biopsy forceps with excretion lips forceps through the distal opening of the channel. Rolled in a tube fragment complex bioplastic material, cut to the size of the ulcer (1-2 cm in diameter), fixed biopsy forceps. Performed endoscopic examination, during which a comprehensive bioplastic material stack on ulcerative defect using biopsy forceps. The procedure is carried out once with the control endoscopic examination after 5-7 days. The method provides a reduction of possible scarring ulcers and scarring of the long-term healing of ulcers, not treatable by other means.
Examples of specific performance.
Patient W., 39 years old, was admitted to the reception area 11.09.2012, with complaints of weakness, vomiting "coffee grounds". Ulcer history denies. Admission: state of moderate severity. Pale skin color. The heart rate of 108 beats / min, HELL 10/60 mm Hg Abdominal palpation soft, pain in the epigastrium. When the finger examination of the rectum on the glove defined black feces. Made fibrogastroduodenoscopy: on the back of the bulb of the duodenum revealed ulcerative defect to 1.5 cm in diameter to a depth of 0.5 cm with spots of hydrochloric acid gamut is on. Conclusion: chronic duodenal ulcer complicated by bleeding. Low risk of recurrence (Forrest IIC). Hospitalized in the surgical Department.
The branch was held conservative hemostatic therapy, antiulcer therapy (proton pump inhibitors in/in). Against the backdrop of ongoing conservative treatment condition improved. When control EGD after 24 hours, the bottom of the ulcer is covered by fibrin. On ulcerative defect produced endoscopic applique bioplastic material. In the future the patient received conservative antiulcer therapy at lower doses, including proton pump inhibitors oral and H. pylori drugs. Fibrogastroduodenoscopy control after 5 days after application - healing ulcers.
Patient D., 48 years old. Suffering from gastric ulcer for 6 years. Twice a year exacerbation of ulcer. Were outpatients and inpatient with temporary success. Last exacerbation with 15.10.2012, were outpatients received proton pump inhibitors oral and H. pylori drugs. Due to the lack of effect 30.10.2012 was admitted to the medical Department, where he received complex antiulcer drugs (blockers of the proton pump, antibiotics, antacids, vitamins). On a background of treatment pain decreased, but e is roscopically positive dynamics were absent. Fibrogastroduodenoscopy control from 10.10.2012, ulcer on the lesser curvature of the stomach 2 cm in diameter. Performed endoscopic applique bioplastic material on ulcerative defect. In the future the patient received conservative antiulcer therapy, including proton pump inhibitors oral and H. pylori drugs. Fibrogastroduodenoscopy control after 5 days after application: the defect was reduced to 1 cm, the bottom filled with granulation tissue. Fibrogastroduodenoscopy control within 10 days after application: the defect is healed.
Thus, compared with the prototype method endoscopic bioplastics gastroduodenal ulcers complex bioplastic material provides:
- improving the efficiency of endoscopic treatment of gastroduodenal ulcers;
- prevention of surgical operations;
- a significant reduction in terms of tissue regeneration of the mucous membrane of the body, and consequently the time of the patient's stay in hospital.
A method of endoscopic bioplastics gastroduodenal ulcers complex bioplastic material, including endoscopic access, characterized in that the working channel of fibrogastroduodenoscopy enter biopsy forceps with rolled-integrated bioplastic material, cut to the size of the ulcer, stack on ulcerative defect with the aid of the completion of the biopsy forceps;
and control is carried out by endoscopic examination after 5-7 days, with bioplastic material contains hyaluronic acid, a phosphate buffer system, omeprazole and clarithromycin in the following ratio, wt %:
|phosphate buffer system||5|
SUBSTANCE: 1 glass of an aqueous infusion of swallowwort herb or garden sage herb is orally administered daily on an empty stomach in the morning 1-2 hours before meals for 10 days. That is followed by administering an aqueous infusion of camomile blossom daily on an empty stomach for 10 days also. For the further 10 days, an aqueous infusion of plantain leaves is administered daily on an empty stomach; the infusions of chamomile blossom and plantain leaves are taken in a dose of 1/2 glass 3-5 times a day 30 minutes before meals. Administering the aqueous infusions is combined with orally daily administering an infusion of Saint-John's-wort for 30 days orally in a dose of 50 drops per 1/2 glass of water 3 times a day 30 minutes before meals. After that, the liquid biocomplex Normoflorin is orally administered 3 times a day daily for 4 weeks 30 minutes before meals in age doses. Normoflorin L is used for the first and second administration, and Normoflorin B - for the third one.
EFFECT: effective treatment ensured by Helicobacter pylori growth inhibition, antiseptic, anti-inflammatory herb action improving gastric mucosa trophism in a combination with the positive effect on the nervous system.
SUBSTANCE: invention relates to granules as a laxative, containing particles of magnesium oxide of formula Mg2+ 1-xZn2+ x)O (1) with the average diameter of secondary particles 0.1-25 mcm and apparent specific volume 3-20 ml/g. In formula (1) X represents number from 0 to 0.02, content of magnesium oxide particles constitutes from 80 to 95 wt %. Granules also include mannitol and carmellose and have the average particle diameter 0.2-0.4 mm and bulk density 0.4-0.7 g/ml. Content of particles in granules, which have particle diameter from less than 500 mcm to not less than 355 mcm, constitutes from 30 to 45 wt %, content of particles, which have particle diameter from less than 355 mcm to not less than 180 mcm constitutes from 40 to 50 wt %, content of particles, which have particle diameter from less than 180 mcm to not less than 150 mcm, constitutes from 10 to 28 wt %.
EFFECT: granules of magnesium oxide possess good solubility, attractive taste and outlook and do not leave sense of roughness in the oral cavity.
4 cl, 7 tbl, 2 dwg, 7 ex
SUBSTANCE: group of inventions refers to compositions and methods of treating colitis and other inflammatory intestinal diseases. There are presented: using the compound of the formula (1) or a salt thereof for preparing a drug preparation for treating an inflammatory disease of intestinal epithelial tissue (particularly, indeterminate colitis, Crohn's disease, irritable colon syndrome and ischemic colitis) and a pharmaceutical composition for the same application. What is presented is the pharmaceutical composition for treating colitis containing the compounds of the formula (1) or the salt thereof.
EFFECT: achieving the declared application: what is shown is treating colitis and colon cancer.
35 cl, 3 dwg, 9 tbl
SUBSTANCE: human recombinant interferon alpha-2b is orally administered into a patient's body as an ingredient of an anti-acid protective medium in a dose of 500 thousand IU twice a day for at least 7 days. The length of the therapeutic course is no more than 14 days. As human recombinant interferon alpha-2b, the preparation contains Reaferon-EC or Reaferon-EC-Lipint; as the anti-acid protective medium, the preparation contains aluminium hydroxide and magnesium hydroxide in the following quantitative ratio: aluminium hydroxide - 25-35 mg/ml; magnesium hydroxide - 15-30 mg/ml; human recombinant interferon alpha-2b - 0.35·105-5·105 IU/ml.
EFFECT: using the given method enables providing higher clinical effectiveness in gastric or duodenal ulcer in a combination with reducing the content of human recombinant interferon alpha-2b in 4 times in a single dose, and in 2 times in a daily dose that is ensured by the preparation delivery directly into the ulcer.
3 cl, 1 tbl, 2 ex
SUBSTANCE: invention relates to compounds of general formula or , where Ar1 represents phenyl group, optionally substituted with one or several identical or non-identical halogen atoms; R1 represents hydrogen atom; R4, R5, R6a, R6b represent hydrogen atoms; Y, Z independently represent linear C1-4 alkylene group, optionally substituted with one linear C1-4 alkyl group; Ar2 stands for condensed with benzene 5-membered heterocyclic ring, containing one nitrogen atom and one sulphur atom, substituted with one linear C1-4 alkyl group, or derivative of 5- or 6-membered heterocyclic ring, containing one nitrogen atom and one sulphur atom, condensed with heteroaromatic 6-memebered ring, containing one or two nitrogen atoms, substituted with one linear C1-4 alkyl group, linear C1-4 alkoxygroup or group -NR7R8, where R7 and R8 independently stand for hydrogen atom, linear or branched C1-4 alkyl group, or R7 and R8 together with nitrogen atom form group of general formula , where R2, R3 represent linear C1-4 alkyl groups, A stands for group -CHR12, oxygen atom or group -NR9, where R12 and R9 stand for hydrogen atom or linear C1-4 alkyl group, m has value 1 or 2, n has value 1 or 2, o has value 0 or 1, p has value 0 or 1, Q stands for group -O-, group -N--H or group -N--CO-R10, where R10 stands for linear C1-4 alkyl group or -NH-R11 group, where R11 represents linear C1-4 alkyl group; and to their salts. Invention also relates to methods of obtaining therein and to based on them pharmaceutical composition, possessing antagonistic activity with respect to receptor CCR3.
EFFECT: obtained are novel compounds and based on them pharmaceutical compositions, which can be applied in medicine for obtaining medication, intended for treating asthma, allergic rhinitis, atopic dermatitis, eczema, inflammatory intestinal diseases, ulcerous colitis, Crohn's disease, allergic conjunctivitis, multiple sclerosis or HIV-infection and AIDS-associated diseases.
14 cl, 3 tbl, 26 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed is application of preparation DAM+™ for injection treatment of gastroesophageal reflux (gastroesophageal reflux disease).
EFFECT: described is recovery of locking function of gastroesophageal junction with absence of migration, which contributes to extension of arsenal of medications used for treatment of the disease.
5 dwg, 1 tbl
SUBSTANCE: group of inventions relates to biotechnology and medicine. Disclosed is a polysaccharide which is isolated from the Bifidobacterium infantis NCIMB 41003 strain and has the structure [-β(1,3)-D-GalpNAc-β(1,4)-D-Glcp-]n, where said disaccharide unit repeats n times, which yields a polysaccharide with molecular weight greater than 100000 Da. The polysaccharide exhibits immunomodulating activity and is used in preparing medicinal agents for treating or preventing undesirable inflammatory activity, undesirable gastrointestinal inflammatory activity, rheumatoid arthritis and autoimmune disorders.
EFFECT: pharmaceutical composition for treating and preventing inflammatory disorders and a food product containing the isolated polysaccharide are disclosed.
9 cl, 6 dwg, 3 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to using mixed metal compounds for preparing a drug preparation for neutralisation of gastric acid or buffer action thereon, as well as for treatment of a condition or a disease related to high gastric levels of acid. The mixed metal compound is a compound of formula (I): MII 1-aMIII aObAn- c.zH2O (I), wherein MII and MIII mean a two-valence and three-valence metal respectively, An- means an n-valence anion, 0.2≤a≤0.4, 0.2≤b≤1.5, 2+a is equal to 2b+Σcn, Σcn<0.9a, and z is equal to 2 or less. According to the invention, the mixed metal compound is presented in the form of a granulated material, wherein a diametre of 50 wt % of the granules makes 106 to 1180 mcm with the material comprising 50 wt % of the mixed metal compound, 3 to 12 wt % of noncovalent water and no more than 47 wt % of an excipient on granulated material weight basis. The mixed metal compound in the form of the granulated material represents a compound of formula (I) or a compound of formula (III): MII 1-xMIII x(OH)2An- y·mH2O (III) ; wherein MII and MIII mean a two-valence and three-valence metal respectively, An- means an n-valence anion, x=Σyn, 0<x≤0.4, 0<y≤1, and 0≤m≤10.
EFFECT: invention provides the buffer action on gastric acid, causing no effect of rebound acid hypersecretion.
46 cl, 3 tbl, 1 dwg
SUBSTANCE: present invention relates to organic chemistry and specifically to substituted imidazo[1,2-a]pyridines of formula I
where R is -CH2COOH or -COOH. The invention also relates to a method of producing a compound of formula I and use of the compound of formula I.
EFFECT: obtaining novel substituted imidazo[1,2-a]pyridines, which inhibit exogenically or endogenically stimulated secretion of gastric acid and which can be used in preventing or treating diseases associated with gastric acid, and inflammatory gastrointestinal diseases.
6 cl, 3 ex
SUBSTANCE: present invention relates to a novel prostaglandin I2 derivative or a pharmaceutically acceptable salt thereof, specifically a 7,7-difluoro-PCl2
(formula (1)) derivative, where R1 and R2 each independently denote a hydrogen atom or an alkyl group with a straight chain, having 1-3 carbon atoms, R3 is a hydrogen atom, an alkyl group, having 1-4 carbon atoms, as well as a medicinal agent based on compounds of formula 1 for treating and preventing various diseases of the gastrointestinal system.
EFFECT: obtaining a novel prostaglandin I2 derivative or a pharmaceutically acceptable salt thereof.
22 cl, 23 ex, 4 tbl, 12 dwg
SUBSTANCE: claimed invention relates to biocompatible polyisocyanate macromer or mixture of macromers for application as glue or sealant for internal application, represented by formula: , where f equals two or more; a in the range from 1 to 5 and R1 represents , where d is in the range from 0 to 5 and c can be in the range from 1 to 100; R2 represents , where R3 represents linear or branched residue of water-soluble polymer, which forms ester bonds with R4 and urethane bonds with R1, when a equals one or more; and R4 represents linear or branched organic residue, which contains two or more carboxylate terminal groups, and x gives the number of repeating R4 and is in the range 2≤x≤6. Also described are biocompatible elastic gel, obtained by polymerisation of said macromer, composition, applicable for medicine, and method of internal wound closing.
EFFECT: creation of glue or sealant for internal application, preserving ability for manipulations and smoothing, which fills internal sinuses and empty spaces, penetrates and tightly fits cavities and pores of tissue before hardening or setting, and is biologically decomposable.
9 cl, 3 tbl, 3 ex
SUBSTANCE: thread is produced from polyethylene of super-high molecular weight with characteristic viscosity of 8-40 dl/g. Note here that said thread features creep rate defined at 70°C and 600 MPa equal to at most 5-10-6s-1. Complex thread produced from polyethylene of super-high molecular weight with characteristic viscosity of 8-40 dl/g containing 0.2-10 alkyl groups C1-C4 per 1000 atoms of C features creep rate defined at 70°C and 600 MPa equal to at most 3-10-6s-1. Invention covers also semi-finished articles including said thread, particularly, super-strong ropes, bullet-proof modules, medical implants.
EFFECT: better thread characteristics.
14 cl, 4 dwg, 5 tbl, 28 ex
FIELD: technological processes.
SUBSTANCE: invention is related to medicine. Biodegradable and biocompatible single-core fibres and netted implants from them are described, preserving high strength properties for a long period of time. Surgical fibre is described on the basis of a biodegradable polymer with absolute strength of at least 306 MPa, consisting of a copolymer 3-hydroxybutyrate and 3-hydroxyvaleriate and containing 3-hydroxyvaleriate in amount from 5 to 95 mol %. Copolymer has molecular weight of at least 600 kDa. Copolymer has an extent of crystallinity of not more than 60%. The method is described to produce medical sutural fibre, including melting of copolymer 3-hydroxybutyrate and 3-hydroxyvaleriate, extrusion and alignment of single-core fibre.
EFFECT: production of surgical fibre of different diameter with high strength parameters, which preserves integrity and strength when implanted into a body for a long period of time and suitable for use as surgical sutural threads and surgical netted implants.
8 cl, 8 dwg, 6 ex
SUBSTANCE: connecting element (10) is described, in particular a suture material for surgical application, which contains the first material (12) which is substantially rigid when its opposite sides are affected with respectively short-term tensile load, and the second material (11) connected with first material. The second material is substantially rigid when its opposite sides are affected with tensile load, and is made with the ability for slow shortening during the second period of time, longer than the first period of time.
EFFECT: connecting element shrinks over long periods of time and is rigid at short-term fast-increasing loads.
23 cl, 22 dwg
SUBSTANCE: invention relates to a method of obtaining polysaccharide fibre for making materials, specifically for making surgical suture materials absorbable in a human and a mammal body, absorbable and non-absorbable dressing material and absorbable textile matrix materials. The method is characterised by that 2.4-4.0 wt % solution of polysaccharide in dimethylacetamide which contains 4.56-10.00 wt % lithium chloride is mixed with 1.0-5.0 wt % poly-N-vinylpyrrolidone with molecular weight of 8-35 kDa or a metallopolymer complex - fine-grained silver stabilised by poly-N-vinylpyrrolidone in such an amount that, content of fine-grained silver relative polysaccharide dissolved in spinning solution ranges from 0.07 to 0.87 wt %. Mass ratio of polysaccharide: metallopolymer complex equals 88.0-99.0:1.0-12 wt %. The mixture is intensely stirred, held, filtered, degassed and the obtained spinning solution is extruded at room temperature into an alcohol deposition tank in form of water-soluble aliphatic C2 and C3 alcohols. The fibre is then processed in plastification and washing tanks and dried.
EFFECT: obtaining fibre with good deformation and strength properties.
1 dwg, 4 tbl, 29 ex
SUBSTANCE: invention relates to technology of obtaining complex fibres from high-quality polyethylene. Method includes obtaining polyethylene solution with superhigh mole weight in solvent; formation of fibres from solution through forming plate with at least 5 spinning holes, and through air clearance, drawing out obtained liquid elementary fibres with drawing out degree in liquid medium DR liquid.; cooling of liquid elementary fibres with obtaining gel-like elementary fibres containing solvent; extraction of solvent and performing drawing out of elementary fibres in at least one stage before, during and/or after extraction of solvent with degree of drawing out DRsolid., equal to at least 4. Each spinning hole includes zone of narrowing characterised by specific size and further zone characterised by diametre Dn and length Ln with value Ln/Dn within the range from 0 to 25, with obtaining as a result degree of drawing out DRliquid=DRs.h×DRa.c., equal to at least 150, where DRs.h. - degree of drawing out in spinning holes, exceeding 1, and DRa.c. - degree of drawing out in air clearance, equal to at least 1. From obtained complex fibres from high-quality polyethylene semi-finished products or products of consumptive use, including ropes and bulletproof composites, are produced.
EFFECT: elaboration of efficient technology of obtaining complex fibres from high-quality polyethylene.
30 cl, 4 dwg, 5 tbl, 29 ex
SUBSTANCE: invention can be used for production human and mammal body absorbable surgical suture materials and absorbable wound textiles. Milled chitin-containing natural raw materials (for example, crab shells) are processed many times at 4-10°C, preferable at 4-5°C using aqueous solutions of hydrochloric acid and alkali, then rinsed with water, aqueous solution of weak acid, water, acetone. Produced dry product is dissolved in dimethylacetamide containing lithium chloride 4.56-10.0 wt % to produce chitin solution 2.4-4.0 wt %. Produced solution is extruded at room temperature to alcoholic setting bath, passed through aqueous stretch and rinsing baths; thus alcoholic setting bath is water-soluble aliphatic alcohols C1-C3, preferably C2 and C3.
EFFECT: sufficient elongation and durability especially for surgical suture material.
1 tbl, 1 dwg, 13 ex
FIELD: medicine, surgical materials.
SUBSTANCE: the present innovation deals with surgical suturing material that includes ligature consisting of the nucleus out of polyamide twisted or woven ligature with membrane out of chitosan at addition of antibiotic as medicinal preparation; it has been described surgical suturing material that includes ligature consisting of the nucleus out of polyamide twisted or woven ligature with chitosan membrane with addition of antibiotic preparation and biologically active substances based upon the biomass of Aralia-group plants or monohydrate-1-hydroxygermatran; it has been suggested surgical suturing material that includes ligature consisting of the nucleus out of polyamide twisted or woven ligature with chitosan membrane with addition of antibiotic preparation, biologically active substances based upon the biomass of Aralia-group plants or monohydrate-1-hydroxygermatran and anti-tumor preparation. The innovation provides combined biological action upon wound surface and favors rapid treatment and healing of wounds.
EFFECT: higher efficiency.
3 cl, 19 ex, 1 tbl
SUBSTANCE: method involves producing superficial scleral flap and creating intraocular fluid discharge zone. Sinustrabeculectomy is carried out or non-penetrating sclerectomy. Scleral bed is sutured with 7-10 stitches making step of 0.5-1.5 mm in continuous suture from polymer suture material of 7/0-9/0 in longitudinal and transverse direction. The suture goes outside scleral bed boundaries by 5-8 mm on each side. Then, the superficial scleral flap is fixed.
EFFECT: increased anterior and posterior intraocular fluid discharge; enhanced effectiveness in preventing sclero-conjunctival cicatrisation of peripheral filtering cushion.
SUBSTANCE: surgical thread is provided with inclined protrusions-notches formed as conical burrs with sharpened plastoelastic ends and sequentially positioned lengthwise of thread. Burrs are positioned at one or both sides of thread section (for example in staggered arrangement) with alternating inclination of burrs. Thread is not attached to surgical needle and is introduced into soft tissues through injection needle clearance.
EFFECT: increased efficiency by using protrusions formed as burrs allowing rupture strength of thread to be kept and functional designation, that is, usage in conducting of aesthetic cosmetic operations, to be fulfilled.
6 cl, 8 dwg
SUBSTANCE: compounds can be applied for treatment of oncologic and autoimmune diseases. Invention also characterises method of obtaining conjugates, pharmaceutical composition and medication, which contains modified proteins. In general formulae 1 or 2 , R1 is selected from the group representing (CH3)2N-,
R2 is selected from the group representing where R3 as terminal substituent represents -NH2, or and R4 represents H or C1-C3alkyl.
EFFECT: novel compounds possess affinity for CD16a receptor.
18 cl, 20 dwg, 3 tbl, 19 ex