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Method of treating gastritis

IPC classes for russian patent Method of treating gastritis (RU 2519766):
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FIELD: medicine.

SUBSTANCE: 1 glass of an aqueous infusion of swallowwort herb or garden sage herb is orally administered daily on an empty stomach in the morning 1-2 hours before meals for 10 days. That is followed by administering an aqueous infusion of camomile blossom daily on an empty stomach for 10 days also. For the further 10 days, an aqueous infusion of plantain leaves is administered daily on an empty stomach; the infusions of chamomile blossom and plantain leaves are taken in a dose of 1/2 glass 3-5 times a day 30 minutes before meals. Administering the aqueous infusions is combined with orally daily administering an infusion of Saint-John's-wort for 30 days orally in a dose of 50 drops per 1/2 glass of water 3 times a day 30 minutes before meals. After that, the liquid biocomplex Normoflorin is orally administered 3 times a day daily for 4 weeks 30 minutes before meals in age doses. Normoflorin L is used for the first and second administration, and Normoflorin B - for the third one.

EFFECT: effective treatment ensured by Helicobacter pylori growth inhibition, antiseptic, anti-inflammatory herb action improving gastric mucosa trophism in a combination with the positive effect on the nervous system.

1 ex

 

The invention relates to medicine, in particular to a gastroenterologist, and can be used for the treatment of chronic gastritis in adults and children.

There is a method of treatment of chronic gastritis and peptic ulcer disease duodenal ulcer, characterized by the fact that the patient is orally administered a solution of bactisporin 3 doses 3 times a day before meals in the first 3 days, then 2 doses 2 times a 7 days. The method allows the influence of Helicobacter pylori infection and to stimulate the regeneration of the mucous membrane of stomach and duodenal ulcers, prevents the development of dizbakterioz [patent RU 2187318, 2002].

There is a method of treating periodontal disease, combined with gastric ulcer and duodenal ulcers, comprising the application on periodontal tissues and intake of 40% alcohol tinctures of medicinal collection, consisting of calendula flowers, chamomile flowers, grass, knotweed, taken in equal mass parts, with the dissolved ecdysterone to a 0.01% solution of [patent RU 2205653, 2003].

There is a method of treatment of chronic H. pylori-associated gastritis by monotherapy probiotic "Laminolact" in a dose of 3 pills 3 times a day for 1 month. The method ensures elimination of Helicobacter pylori infection on the background of activation of the local immune response in the gastric mucosa through environmenta is I on the microflora and the immune system of the colon [patent RU 2246957, 2005].

There is a method of treatment of erosive and ulcerative lesions of the gastric mucosa, characterized by the fact that prescribe esomeprazole dose of 20 mg 1 time a day before meals. Appoint a mixture of freeze-dried culture Lactobacterium plantarum 8P A3 at a dose of 4×1091 ml of suspension and Almagell in the ratio of 1:1. The mixture is prepared before use, the dose of 25 ml 3 times a day for 30-40 minutes after ingestion, the course of treatment is 21 days [patent RU 2449787, 10.05.2012].

The prototype of the invention is a method of treatment of Helicobacter pylori associated chronic gastric ulcer and duodenal ulcer, namely, that conduct medical therapy, including oral administration of bismuth subcitrate, omeprazole, amoxicillin and furazolidone, immunomodulator microbial origin and complex bifidobacteria and lactobacilli. As immunomodulator microbial origin enter ribomunyl at a dose of 750 mg In the first month 1 time per day in the morning on an empty stomach in the first 4 days of each week. In the next 2 months - the first 4 days of each month. The complex of bifidobacteria and lactobacilli (LB-complex) 5 ml, within 25 days from the first day of taking antibiotics. Admission 30 minutes before a meal. The content of microbial cells in 1 ml of the complex 1010-1012[patent RU 2416408, 2011]. The disadvantages of the top the fashion is a large drug loading and associated with the excretion of drugs functional overload of the liver and kidneys, also toxic effects on the gastrointestinal tract, Central nervous system, musculoskeletal, genito-urinary, hematopoietic system, and so on, the use of antibiotics causes resistance of microorganisms to them, the inability to penetrate through the protective layer of gastric mucus, which leads to the elimination of the normal microflora and the preservation of pathogenic (H. pylori colonize under a layer of mucus), which is the cause of dizbakterioz, immunodeficiency and reduced colonization resistance, preservation of pain and dyspeptic phenomena ("posteradication syndrome"), the timing of recovery of the gastric mucosa is questionable, used drugs should not be administered to children, besides the treatment of the prototype during pregnancy may be teratogenic factor.

The technical result in the use of the invention is the prevention of side effects of medicines, providing therapeutic effect of herbal extracts on the body as a whole system, the mucous of the stomach and improve the functional state of the stomach, the regulation of the Central nervous system, gastrointestinal tract and urinary system, natural stimulation of biological processes of the immune system, reducing the time of regeneration of the mucosa with minimal risk of metaplasia and carcinogenesis, the use in pediatric patients and patients with diseases of the kidneys and the liver

This technical result is achieved in that in the method of treatment of gastritis, including exposure to pathogens and colonization of the mucosa of the gastrointestinal tract lacto - and bifidobacteria, according to the invention for exposure to pathogens daily on an empty stomach in the morning for 1-2 hours before eating orally administered aqueous extract of the herb celandine or herb sage dose of 1 Cup for 10 days, then within 10 days daily on an empty stomach water infusion of chamomile flowers, in the next 10 days daily on an empty stomach aqueous extract of plantain leaves, and extracts of chamomile flowers and leaves of the plantain is administered at a dose of 1/2 Cup 3-5 times a day 30 minutes before meals, along with water infusions within 30 days daily orally administered tincture of St. John's wort dose of 50 drops in 1/2 glass of water 3 times a day 30 minutes before meals, after which to inhibit the growth of Helicobacter pylori and increased colonization potential of the mucous membrane of the gastrointestinal tract daily for 4 weeks, 30 minutes before meals 3 times a day orally administered solution of Normoflorin in age, dosage, and the first and second drug use Normalien L, and in the third Normalien B.

The proposed method for the treatment of gastritis as follows. In the background is edenia healthy lifestyle (daily regimen compliance, including avoiding stressful situations); the rational and full (balanced, benign) power; maximum limits, if possible cessation, alcohol intake, tobacco Smoking, taking synthetic drugs that cause changes of the gastric mucosa, sanation of an oral cavity, to restore the function of the digestive tract, urinary system and exposure to pathogens daily on an empty stomach in the morning, 1-2 hours before meals, disposable, the dose of one Cup (one teaspoon of dried herb without the top on the glass boiling water) orally administered aqueous extract of the herb or herb sage (one teaspoon of dried herb per Cup of boiling water) for 10 days, then within 10 days daily on an empty stomach water infusion of chamomile flowers, in the next 10 days (optionally following 40 days) daily on an empty stomach aqueous extract of plantain leaves, and extracts of chamomile flowers and leaves of the plantain is administered at a dose of 1/2 Cup (one tablespoon of dried herb per Cup of boiling water) 3-5 times a day 30 minutes before meals, at the same time for the regulation of the Central nervous system with water infusions within 30 days daily orally administered tincture of St. John's wort (50 g chopped dry grass St. John's wort infused 0,5 liters of 40% or 50% alcohol 4 weeks) at a dose of 50 drops in 1/2 glass of water 3 times a day for 30 minutes is about food, then for inhibiting the growth of Helicobacter pylori and increased colonization potential of the mucous membrane of the digestive tract daily for 4 weeks orally 3 times per day of liquid bio-complex Normoflorin in age, dosage, and the first and second drug use Normalien L, and in the third Normalien B: taken by mouth 30 minutes before a meal, immediately shake before use, dilute 1:3 any food liquid is not higher than 37°C.

In the proposed method of treatment, no toxic and immunosuppressive effects of pharmaceuticals obtained synthetically, used herbs and lacto - and bifidobacteria completely natural origin. Does not require preparation in the pharmacy environment.

Causes of chronic gastritis diverse and often combined, often inflammation of the gastric mucosa is the result of dysfunction of several organs and systems. For a full treatment of gastritis, it is important to restore the nervous system, urinary system, gastrointestinal system, histological and cellular levels.

Herbal medicines are easier digested and tolerated by the body (people genetically predisposed for the period of the centuries-old herbal treatments), have a wide therapeutic range and set the your therapeutic effects able to accumulate in the body, means to exert its therapeutic effect for a long time, and probiotics, in addition to restoring the natural microbial balance, possess bacteriostatic and immunomodulatory effects.

Therapeutic effect is achieved due to:

1. The regulation of the nervous system (Hypericum perforatum).

2. Restore the function of all organs of the gastrointestinal tract (full functioning of the glands, so digestion, intake of nutrients, movement of food grains in the gut and so on) and urinary system (to improve cellular metabolism, detoxification) - all used herbs;

3. Symptoms of chronic inflammation of the gastric mucosa, intestinal infusions of herbs:

1) disinfection, antiseptic, vasoconstrictor actions (greater celandine);

2) analgesic reducing inflammation (camomile);

3) promoting regeneration, improve the structure and slizeobrazovanie epithelium of the gastric mucosa (plantain);

4) exposure to pathogens and restore colonization potential of the mucous membrane of the digestive tract (stomach, mouth, intestines) normal microflora (lacto - and bifidobacteria).

Thus, the active components of the herb St. John's wort on anywayt a beneficial effect on the nervous system, of the herb can help to eliminate pathogenic organisms, including Helicobacter pylori. Provided that the inability or unwillingness use celandine, you can replace it with herb Salvia officinalis, has also antibacterial properties. Infusion of chamomile provides an analgesic effect and reduces inflammation, infusion of plantain promotes epithelialization and normalize the activity of the epithelium of the gastric mucosa. On the restored mucous membrane of the digestive tract creates favorable conditions for the colonization of the normal microflora.

It is known that often gastritis or acute, are psychogenic (somatoform disorders and peptic ulcer disease is psychosomatic disease (part of the "Chicago seven"). Hans Selye in his work on stress was noted that erosion is the result of the action of stress on the body. Thus, it is important to restore the functioning of the Central nervous system (antidepressant and calming, restoring balance sympathetic and parasympathetic nervous systems), further the nervous regulation of the digestive tract (motor function of all organs - peristalsis and elimination of spastic phenomena), the regulation of the functions of the digestive glands (secretion of all secrets in the stomach, liver, pancreas, intestine), improve blood circulation and microcircula the tion, neurological trophic transmission of impulses, reflexes, so use alcohol tincture of St. John's wort and extracts of selected herbs.

The herb St. John's wort has a calming, anti-inflammatory, antitumor, improves blood circulation, antiseptic, fungicidal, analgesic, astringent, wound healing, antihelminthic, antispasmodic, cholagogue, diuretic action. The major pharmacological effect of St. John's wort - the effect on levels of serotonin and melatonin in the Central nervous system, regulation of the noradrenergic neurotransmitter systems, which determines the antidepressant properties of plants. The most important ingredient of St. John's wort hypericin (soluble in alcohol) has a positive effect on the nervous system ("Velarium"), without side effects, unlike antidepressant drugs (pharmaceuticals). This substance has anti-microbial (including against Staphylococcus aureus), antiviral effect, improves glycogenolysis liver function, helps lower blood sugar levels, anti-inflammatory and tonic effect. Restores the capillaries due to vitamin e, and ascorbic acid. Vitamins and Pro-vitamins (a, E, PP) restore the metabolic processes of cells, affect the structure and function of the epithelium.

The use of celandine large shopping Mall is in medicine is based on its antispasmodic, hypotensive, antibacterial, antifungal, antiviral, diuretic, antihelminthic, diuretics, cytostatic, cytotoxic (ability to retard the growth of malignant tumors) actions to reduce the reactivity of the autonomic nervous system. A positive property of the herb is that it helps to increase hemoglobin and red blood cells. Helicobacter pylori to maintain its growth can absorb dietary iron, leading to iron deficiency anemia. Used dose grass celandine is not toxic for oral administration.

The chamomile is known antispasmodic, anti-inflammatory, analgesic, soothing, softening, diuretic, choleretic, astringent, hemostatic, a light laxative properties. Chamazulene and azulene enhance regenerative processes, weakens allergic reactions, have a local anesthetic effect, inhibiting lipid peroxidation, have antioxidant effects.

The active substance of plantain inhibit the growth of pathogenic microflora, have a sedative, antispasmodic, hypotensive, anti-allergic, anti-tumor effects. Hemostatic properties are manifested due to the factor T, which improves blood clotting.

Flavonoids contained in herbs, eliminate dyspeptic symptoms in the gastrointestinal tract, have antispasmodic effect on the smooth muscles of the bile ducts, intestines, blood vessels and ureters, anti-inflammatory, wound-healing effect. Alkaloids have a stimulating effect, increase the tone of smooth muscle, stimulate the intestinal peristalsis, bile secretion, the secretion of pancreatic juice (which is important for the timely emptying of the stomach), as well as the secretion of saliva, reduce the proteolytic activity of pepsin, have also expressed, morphine, anesthetic effects, normalize blood pressure and heart rate.

Antacid properties of the extracts is due to two components: increased mucus secretion and enveloping, tanning properties. Reduce the secretion of gastric juice with stress and change its chemical composition to less aggressive contribute to the sedative properties of chamomile.

Characteristic herbs healing effect is achieved by the tanning erosive areas, restore the function of the epithelium (also atrial cilia), vasostimulant granulations and to prevent petechial hemorrhages maseribane surface.

Active substances of the herbs have diuretic and disinfectant urinary tract is a function effectively, what is important to eliminate toxins that have accumulated as the result of dysfunction of the digestive tract, and improve metabolic processes in the body.

Antioxidant activity of herbal extracts, Normoflorins and pronounced antihypoxic effect of plantain important when poor blood supply to the gastric mucosa (tissue hypoxia), ulcers not associated with Helicobacter pylori ("senile plagues").

Another advantage is the cumulative effect of vasoconstrictors, anti-inflammatory, antitoxic, strengthen the vascular wall of the effects of infusions and influence on the chemical composition of mucus lacto - and bifidobacteria, decreasing the concentration of inflammatory mediators. Infusions of medicinal plants have a stimulating effect on the biological activity of lactobacilli, increasing specific, antagonistic, adhesive, lactobacilius activity, antibiotic resistance and resistance to fluids of the gastrointestinal tract of the host. The products of metabolism of flavonoids by lactobacilli possess high antibacterial and fungistatic activity. In addition, lacto - and bifidobacteria can affect different parts of the immune system, regulating, and non-specific cellular and humoral immunity, which provides the power treatment in inflammation and host. Due to the selection of antibiotic like substances, bacteriocins, lactic acid creates a protective biofilm on the mucous membrane of the digestive tract, protecting from viruses, bacteria, fungi, protozoa, saved the presence of colonizing potential. Lactobacilli can colonize even the stomach, which is of great importance for their antagonistic action against H. pylori. In the genome of L.acidophilus (Normalien L) encoded resistance to the acidic environment. Adapted to extreme conditions L.acidophilus, can contribute to growth inhibition and elimination of H. pylori in the stomach. Bacteria Normoflorins L and B are biologically active, start working from the first minute of contact with the mucosa, stimulate the phagocytic activity of neutrophils, macrophages, synthesis of immunoglobulin And participate in the formation of interferon, are able to suppress the production of Ig E, then there is a natural immunomodulator and reduce the sensitization of the organism (as a result of sensitization of the organism H. pylori leads to the formation of abnormally high levels of Ig (E). The product of domestic production, antagonistically active against opportunistic pathogenic flora of our region.

The treatment can be carried out in an outpatient setting - allows you to reduce the inflammation, to achieve a rapid regeneration of the mucous membrane and d is sustained fashion remission of the disease. Treatment of gastritis in this way ensures the prevention of complications of the disease, as prevention of erosive gastritis, gastric ulcer, intestinal metaplasia and dysplasia, polyps, gastric bleeding, stomach cancer, anemia, beriberi, dizbakterioz intestine.

In this way treated 18 patients. In all cases, was achieved this technical result.

The invention is illustrated by the following example.

ASF, born in 1972, after the stress has made a complaint to: the feeling of heaviness and discomfort in the upper abdomen, belching air, bloating, rumbling, unstable stool, loss of appetite. Intolerance of antibacterial drugs ("hives"). The results FGS: erosive gastritis, duodenal ulcer.

Appointed adherence to routines, including avoidance of stressful situations; rational and nutrition; treatment: to restore the function of the digestive tract, urinary system and exposure to pathogens daily on an empty stomach in the morning, 1-2 hours before meals, disposable, the dose of one Cup (one teaspoon of dried herb without the top on the glass boiling water) orally to enter the aqueous extract of the herb celandine within 10 days, then within 10 days daily on an empty stomach water infusion of chamomile flowers during the following 10 days daily on an empty stomach aqueous extract of plantain moreover, infusions of chamomile flowers and leaves of plantain to enter at a dose of 1/2 Cup (one tablespoon of dried herb per Cup of boiling water) 3-5 times a day 30 minutes before meals, at the same time to regulate the functioning of the nervous system with water infusions within 30 days of daily oral to enter a tincture of St. John's wort (50 g chopped dry grass St. John's wort infused with 0.5 liters of 40% or 50% alcohol 4 weeks) at a dose of 50 drops in 1/2 glass of water 3 times a day 30 minutes before meals, after which to inhibit the growth of Helicobacter pylori and increased colonization of the mucous membrane potential coat of stomach daily for 4 weeks orally 3 times per day of liquid bio-complex Normoflorin in age, dosage, and the first and second drug use Normalien L, and in the third Normalien B: taken orally 30 minutes before a meal.

Within 2 weeks, decreased irritability, discomfort and heaviness in the epigastrium, bloating. By the end of treatment were stopped all symptoms during the year recurrence was not observed. When the control endoscopy after 3 months: the healing of erosions of the stomach and ulcer on the mucous membrane of the duodenal bulb.

A method of treating gastritis, including exposure to pathogens and colonization of the gastrointestinal tract mucosa lacto - and bifidobacteria, different t is m, for exposure to pathogens daily on an empty stomach in the morning for 1-2 hours before eating orally administered aqueous extract of the herb celandine or herb sage dose of 1 Cup for 10 days, then within 10 days daily on an empty stomach water infusion of chamomile flowers, in the next 10 days daily on an empty stomach aqueous extract of plantain leaves, and extracts of chamomile flowers and leaves of the plantain is administered at a dose of 1/2 Cup 3-5 times a day 30 minutes before meals, along with water infusions within 30 days daily orally administered tincture of St. John's wort dose of 50 drops per 1/2 Cup water 3 times a day 30 minutes before meals, after which to inhibit the growth of Helicobacter pylori and increased colonization potential of the mucous membrane of the gastrointestinal tract daily for 4 weeks, 30 minutes before meals 3 times a day orally administered solution of Normoflorin in age, dosage, and the first and second drug use Normalien L, and in the third Normalien B.

 

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