Medical wipe for external use

FIELD: medicine.

SUBSTANCE: dressing represents a knitted mesh fabric coated with a composition of a biocompatible film-forming polymer of polyvinyl pyrrylidone and drug preparations: iodine, novociane, carboxymethyl cellulose sodium salt, of the following formulation (mg/cm2): iodine 0.0282±20%; polyvinyl pyrrylidone (Mr 20000) 1.2±20%; novociane 0.426±20%; carboxymethyl cellulose sodium salt 1.6-1.9.

EFFECT: using the wipe provides antimicrobial, antiseptic, disinfecting, antifungal and antiprotozoal action ensured by the fact that a polyvinyl pyrrylidone matrix retains iodine in the wipe and promotes its release on the skin.

 

The invention relates to chemical-pharmaceutical industry, namely to the production of dressing materials (napkins, bandages and so on)for wound closure in the provision of surgical, combustionengines assistance, and medical assistance in disaster medicine and pharmacy of extreme situations. In General, the invention is multifunctional and is used to treat wounds and burns in all phases of wound healing by application to the wound.

Currently, there are many dressing materials used in operations and dressings for drainage of wounds, stop bleeding, prevent infection of the wound. For dressing tools include gauze, bandages, napkins.

On the Russian pharmaceutical market presents dressings LLC Paul Hartman. This dressing Peruvian balsam Branolind N. balsam of Peru has antiseptic and wound-healing effects, so it is used for treatment of burns, venous and diabetic ulcers, decubitus ulcers, abscesses, boils, grazes and other poorly healing wounds. The disadvantage of these dressings is their high cost (on average 30-50 rubles per piece).

Among Russian manufacturers on the market dressing devices lead headbands ZAO Biotechpark" (Vecoplan, Paliparan, Geel Is Pran and others). In these tissues the basis of beeswax introduced medications, providing wound healing and analgesic effects. Beeswax is a product of beekeeping with the whole spectrum of biologically active substances. However, it is the basis of waxes consisting of esters of palmitic, neoceratodus, melissinos acid, imparts hydrophobicity. When the bandage is on bee wax on the wound occur processes mikroarmirovanie wounds that adversely affects the healing process.

Napkin "Al" group of companies "Altex" RF patent No. 2101033 "dressings with prolonged therapeutic effect" from 10.01.1998, is the closest analogue to the claimed technical solution. This napkin is made of knitted fabric, which caused the composition of the biocompatible gel-forming polymer and drugs: chlorhexidine, furagin, lidocaine. The cloth has a long-lasting antimicrobial action due to the content of chlorhexidine and furagin, and basic wound healing and analgesic action due to lidocaine. It is designed for first aid and treatment of limited household burns I-III A degree.

However, we noted that antiseptic and wound-healing properties of the tissues under the patent of R. the No. 2101033 not optimal.

The task of the invention is to make the dressing tool complex antiseptic, anesthetic, improved sorption and atraumatic properties, ensuring low cost of treatment and increase the shelf life of the dressing tool.

The technical result is that provided antimicrobial, antiseptic, disinfectant, antifungal and Antiprotozoal actions due to the fact that the matrix polyvinylpyrrolidone holds the iodine in the tissue and contributes to its release on the skin. While in the nearest analogue is provided only antiseptic and antimicrobial action due to the pharmacological properties chlorexidine and furagin.

This technical result is achieved by the inventive napkin, comprising a carrier coated with a complex of a biocompatible polymer and a drug, characterized in that it contains as a carrier knitted mesh fabric coated with the composition of the biocompatible film-forming polymer is polyvinylpyrrolidone and drugs: iodine, procaine, sodium carboxymethyl cellulose, of the following composition (in mg/cm2):

Iodine0,0282±20%
Polyvinylpyrrolidone (Mr 20000)1,2±20%
Novocaine0,426±20%
Sodium salt of carboxymethylcellulose1,6-1,9

Cotton mesh fabric has a weight of 180 g/m2size 10∗10.

When creating this dressing material was taken into account the fact that iodine is a well known drug and is widely used in medicine as a solution of iodine alcohol for local and external applications. The complex of iodine with polyvinylpyrrolidone based drug yodopiron with antiseptic due to iodine and wound through polyvinylpyrrolidone actions. The use of novocaine provides an analgesic effect.

The advantage of this dosage form in front of the closest analogue is that in its composition a complex of iodine with polyvinylpyrrolidone. Matrix polyvinylpyrrolidone holds the iodine in the tissue and contributes to its release on the skin. Due to this mechanism are provided antimicrobial, antiseptic, disinfectant, antifungal and Antiprotozoal activities. While in the nearest analogue is provided only antiseptic and antimic is one of action due to the pharmacological properties of chlorhexidine and furagin.

The analgesic properties of tissues can be achieved by the introduction into it of the local anesthetic products - novocaine. The choice of novocaine compared with lidocaine is preferred due to the fact that the toxicity of novocaine for exterior use less. Molecule novocaine has a greater ability to form intermolecular bonds at the expense of primary aromatic amino groups, ester, tertiary amino groups, which determines its complexation with iodine and better absorption from the surface.

The finished form of the dressing material is a cloth with antiseptic, antimicrobial, disinfectant, antifungal and antibacterial action on cotton knitted base impregnated with a biocompatible, gel-forming polymer and incorporating the complexes of iodine-novocaine and iodine-polyvinylpyrrolidone. Optimal characteristics due to the composition, gives the product a high value of absorption (sorption capacity of 3.7 and selective sorption, antimicrobial and local anestesiologia action.

As a result of this complex action of the components of the proposed dressing tool, healing is much faster.

Use this dressing tool externally for first aid, on which I treat cuts, cracks, ulcers, nonhealing wounds, diaper rash, burns third degree.

Getting burns drug "Novocom" local actions for external use occurs in several stages.

The first step is the synthesis of this complex, which in turn consists of several stages: mixing in the mixer powdered polyvinylpyrrolidone with a molecular weight of 20,000 (930 g), finely ground crystals of iodine (60 g) and procaine (200 g) for 1 h at room temperature, then heated in the mixer to a temperature of 75°C for 5 h, and further cooling the mixture in a dark place. Synthesized the drug in appearance is amorphous brown powder, soluble in water and in ethanol.

The second stage is actually making napkins. To do this, on the basis of the obtained powder to prepare a solution of 3,3% concentration. The cloth is made of fibrous-porous fabric measuring 3×3 cm, made by soaking the resulting solution and further drying at a temperature of 25°C during the day.

To determine the concentration of ingredients in the mixture used titrimetric methods. The quantitative content of substances meets the requirements of the state Pharmacopoeia of the Russian Federation XI edition.

Medical napkin made sagarminaga dressing material with the application of a complex of iodine, novocaine, polyvinylpyrrolidone. The product has a selective sorption of pathogenic microflora and atraumatic properties, providing mariliana products to the wound, it creates an optimal microclimate. The invention provides for obtaining a dressing tool having a high burn-activity, low cost and long shelf life.

The dressing material comprising a carrier coated with a complex of a biocompatible polymer and a drug, characterized in that it contains as a carrier knitted mesh fabric coated with the composition of the biocompatible film-forming polymer is polyvinylpyrrolidone and drugs: iodine, procaine, sodium carboxymethyl cellulose, of the following composition (in mg/cm2):

Iodine0,0282±20%
Polyvinylpyrrolidone (Mr 20000)1,2±20%
Novocaine0,426±20%
Sodium salt of carboxymethylcellulose1,6-1,9



 

Same patents:

FIELD: medicine.

SUBSTANCE: postoperative period involves tamponage with Coletex-AGGDM wet tissue within middle nasal passages. The tamponage area is exposed to laser light in the infrared band at a wave length 0.95 mcm at the output power of 2-3 mWt for 4-5 min. After the exposure, the tissue is left for one day. The following procedures are performed with the tissues placed in the middle nasal passage within a natural fistula and on a mucous membrane of a hard palate in a projection of a maxillary sinus bottom. The tamponage area and skin in the projection of the maxillary sinus within an anterior sinus wall are exposed. 2-3 procedures are performed at the output power of 5-7 mWt for 7-10 min for one field. 4-6 procedures are performed at the power of 15-20 mWt for 3-10 min for each field. After the exposure is terminated after each procedure, the endonasal tissue is left for 6-8 hours.

EFFECT: method enables providing higher clinical effectiveness by antibacterial, antiseptic, anti-oedematous effects, recovering the ciliary transport function without injuring the ciliated epithelium; eliminating the postoperative complications, such as sinus bleeding and cicatrical deformity of the mucous membrane.

2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry and represents a copper-bearing cellulosic material possessing the fungicidal, bactericidal and deodorant properties, containing a cellulose matrix coated with copper particles prepared by chemical reduction of copper ions absorbed in the cellulose matrix, differing by the fact that the copper ions absorbed in the cellulose matrix are reduced in micelle solution of a cationic surfactant; the material contains copper and copper oxide nanoparticles with the size of 5-19 nm and has a composition as follows, wt %: cellulose matrix 99.5-98.0, copper nanoparticles 0.5-2.0.

EFFECT: said materials can find application in manufacturing sanitary products.

2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine. What is described is a method for preparing a transdermal therapeutic system based on poly(lactic-co-glycolic acid) involving dissolving poly lactide-co-glycolide and a pharmaceutically active substance in an organic solvent, mixing the prepared solution until dissolved completely, hot air drying until dry completely and having a constant weight to prepare a film, cutting the film into sections and packing, with the relation of lactide and glycolide varying within the range of 95:5 to 5:95 (versions).

EFFECT: preparing the transdermal therapeutic system based on poly(lactic-co-glycolic acid) that is biodegradable.

33 cl, 1 dwg, 3 tbl, 6 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to traumatology and orthopaedics, enabling preparing a biologically active preparation of autoblood for enhancing neogenesis processes. The presented technique involves sampling whole blood, centrifuging, selecting a middle layer of plasma so that to avoid the erythrocyte ingress. The centrifuged platelet concentrate is frozen in a cold room at temperature below minus 1 C°, dried for at least three minutes within the temperature range of 2 C° to 52 C°; the lyophilisate is sterilised before use.

EFFECT: technique of platelet-rich plasma lyophilisation enables preserving the TGF PDGF VEGF factor viability min 1,5 months from the moment of blood sampling.

1 tbl

FIELD: medicine.

SUBSTANCE: what is presented is a boric coating containing a barrier material and an adhesive material. The barrier material and adhesive material are applicable for combined or sequential postoperative application on the mucosal tissue. Such application provides a multilayer film dressing containing a layer of the above barrier material and a layer of the above adhesive material contacting with the barrier material and mucosal tissue. The dressing is left unmoved in place for 48 hours after the postoperative application of the multilayer film on the mucosal tissue. The dressing is absorbed for 14 days. The multilayer film dressing has an external rim surrounding a tonsil bed and a concave centre shaped after the tonsil bed.

EFFECT: reducing or eliminating pain sensations following the mucosal operations, including tonsilectomy, adenoidectomy or other pharyngeal operations.

19 cl, 17 dwg, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, more specifically to dressings used in general surgery, traumatology, obstetrics, gynaecology, proctology, dentistry for closure and healing of wounds (including post-operative), bed-sores, ulcers, burns, complicated purulent and putrid infections with an evident purulo-necrotic layer. A wound and burn closure and healing dressing containing a wound or burn facing therapeutic layer consisting of a therapeutic and sorption agent that is a layer of paste-like gel of iron or aluminium gel with added graphite carbon at 1 g of the additive per 100 ml of the gel, of the thickness of 0.5 cm providing a sorption ability not less than 10 g/g.

EFFECT: preparing the wound and burn dressing possessing high antimicrobial activity and analgesic characteristics, improved sorption ability and atraumatic properties.

7 tbl, 23 dwg

Wound tissue // 2483755

FIELD: medicine.

SUBSTANCE: invention refers to medicine, to preparing a therapeutic and preventing agent for treating radioreactions accompanying the course of radiotherapy. A wound tissue contains a textile fibre-porous material with a viscose component coated with a polymer and a drug preparation introduced therein; the novel is the fact that it is suggested to use the textile material which is made of flax-viscose fibres in ratio of components of flax:viscose 40 - 70 and 60-30, respectively. The fibre-porous material is prepared by needle suturing and has area density 180 g/m2 - 260 g/m2. The coating polymer is sodium alginate, while the drug preparation is introduced in the concentration of 0.25-30 wt %. The drug preparation coating the suggested flax-viscose carrier is presented by poorly soluble preparations of Furaginum, metronidazole, 5-fluoruracil, antioxidant Mexidol, biologically active substances - propolis, sea buckthorn and blackberry extracts.

EFFECT: presented drug preparation has proved itself to be easy to use, enabling higher clinical effectiveness, increasing a prolongation time.

6 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry and represents a sorption plate containing furacilin, differing by the fact that a process for making it involves using the additional excipient therapeutic powdered Kimmeridge clay (blue) Undorovskaya, chitosan solution, dimethylsulphoxide, glycerol, acetic acid and purified water in the following proportions (wt %): furacilin 0.75 - 1.5; dimethylsulphoxide 2.5 - 5.0; blue clay 7.5 - 8.5; 98% acetic acid 1.5 - 3.0; chitosan 2.5 - 4.5; glycerol (7.5 - 8.5); purified water up to 100.0.

EFFECT: invention provides making sorption plates for ensuring wound-healing, anti-inflammatory action in medical practice and higher sorption activity.

9 dwg, 1 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine. What is described is a composition for preparing a polyurethane foam dressing which contains the ingredients in the composition in the following ratio, weight fractions: low-molecular polyesterpolyol No. 1 - 75-90, low-molecular polyesterpolyol No. 2 - 10-25, water - 1.0-2, a foaming agent - 1.0-3.0, an urethane formation catalyst - 0.05-0.3, a co-catalyst - 0.05-0, a foam regulator - 2.0-7.5, a bactericidal additive - 1.0-1.2, aromatic diisocyanate - 30-60.

EFFECT: requiring no additional fixation, the medical dressing is easily applied on a wound surface regardless of a configuration and a size of the injured area, and is formed directly on the patient's wound, providing a sterile surface and an anaesthetic effect; its open porous structure absorbs various wound discharges.

3 tbl

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to method of obtaining medical napkin for treatment of wounds and burns. In method of obtaining medical napkin, which includes carrying out textile material padding in solution of medication with the following drying in the air, padding is carried out in solution of sodium alginate polysaccharide with content of 18-22% dimexide, and after drying by method of textile printing water solution of polymer composition containing 18-22% of urea, 5-7% of sodium alginate is applied on textile carrier, with following drying of processed material in the air. Method makes it possible to considerably increase concentration of medication in napkin, considerably extend spectrum of applied medications, including by low-soluble, as it does not require presence of functional groups in medication for immobilisation on functional groups of fibre.

EFFECT: method is simpler in realisation, less durative, does not require additional processing of textile material, ie more manufacturable and economical.

2 ex

FIELD: medicine.

SUBSTANCE: what is described is a coating in the form of a film which contains the following ingredients, wt %: low-molecular edible chitosan 5.3-5.7, glycerol 2.2-2.8, ceruloplasmin 0.06-0.08, L-asparaginic acid 0.04-0.06, a solvent with pH 5-7 - the rest. What is described is a method for preparing the coating consisting in the fact that a chitosan weigh is diluted in the solvent at 1000 mg of the weigh to 15 ml of the solvent, mixed and placed in a thermostat at a temperature of 37-42°C for 1-2 hours. The mixture is added with ceruloplasmin diluted in the solvent at 1:10 to form a homogenous hydrogel. L-asparaginic acid is diluted in the solvent pre-heated to 37-40°C and added to the mixture to provide pH of the mixture 5-7. A plasticising agent in the form of glycerol is added in the amount of 2.2-2.8% of total volume of the prepared biomass The prepared biomass is placed into containers to form a uniform layer of the coating 3-5 mm high and to form a film by drying the biomass for 18-24 hours in the thermostat at a temperature of 37-40°C.

EFFECT: wound coating provides the highest clinical effect.

6 cl, 6 dwg, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry and medical equipment and may be used in preparing multifunctional biological active structures for the fixation of dressings and objects. The fixation device consists of a paper carrier made of cellulose and viscous fibres impregnated with a special preparation, dried; with its one side of the prepared carrier coated with an adhesive and with its other side coated with a primer and an adhesive.

EFFECT: improved drape effect, enhancement, easier and faster usage.

6 cl, 1 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine. What is described is a superabsorbent polymer composite containing superabsorbent polymers and cellulose nanofibrils having a diameter of 100 nm or less. The composite may be presented in the form of either particles, or foam. There are also described methods for preparing the composite and absorbent products containing the superabsorbent polymer composite.

EFFECT: cellulose nanofibrils improve the gel strength of the superabsorbent polymer.

23 cl, 6 dwg, 6 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to surgery, burn and radiation therapy. A dressing contains rayon fabric which at the first stage of carbon cloth production is exposed to ionising radiation of a high-speed electron bunch in cathode-ray current (1-3) mca and power (0.5-0.7) MeV when transported through an electron accelerator exposure chamber at rate (1-4) m/min; the produced carbon cloth is characterised by density 1.3-1.4 g/cm3; surface density 2.5-3.5 m2/g; carbon content 99.6-99.9 wt %; ash content 0.1-0.4 wt %; chlorhexidine absorption 0.6-0.7 g/g if continuously coating the wound surface for 4 days.

EFFECT: dressing is characterised by high sorption dynamics, does not stick to the damaged skin, and does not scar after burns, cleans the wound surface so that reduces a time for wound preparation for closure in 1,5-2 times due to its high mechanical strength and chemical resistance of the carbon cloth after graphitisation at 2400°C; the dressings are re-useable.

3 ex

FIELD: biotechnologies.

SUBSTANCE: medicine is proposed for limitation of calorie consumption in a patient in need of that, including efficient quantity of a polymer hydrogel prepared by the method including stages of aqueous solution production, including polysaccharide and citric acid; and heating of this solution for removal of water and realisation of cross linkage of polysaccharide with citric acid to form the polymer hydrogel. Also the medicine versions are proposed, in which the polysaccharide is carboxymethylcellulose.

EFFECT: limitation of calorie consumption.

37 cl, 2 dwg, 8 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine. What is described is a solution for preparing a chitosan material, methods for preparing the haemostatic material of the solution and a medical device with using chitosan fibres. The solution consists of the following ingredients in ratio of total amount of the solution, wt %: dry chitosan with a degree of deacetylation - not less than 80%: 4-8 at dry basis, an aqueous solution of a polymer or a mixture of polymers: 1-10 at dry basis, an aqueous solution of an organic acid or a mixture of organic acids in the concentration of 50 - 80% - the rest. The method for preparing the haemostatic material of the aqueous-acidic solution containing a polyelectrolyte complex of chitosan and a water-soluble polymer comprising the electrochemical treatment of the chitosan solution in an electric field with a conductive substrate. The electrospun fibres have the following characteristics: viscosity - 1.4-2.5 Pa·s, surface tension - 31-35 mN/m and electrical conductivity no more than 2.3 mSm/cm due to the use of a viscoelastic solution.

EFFECT: method enables the chitosan fibre of a thinner diameter.

45 cl, 20 dwg, 6 tbl, 16 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine. What is described is a haemostatic composition containing a biologically absorbable material and hyaluronic acid or a derivative thereof. There are described methods for preparing the given compositions, and there are described the applications of the given compositions. Particularly, the method for preparing the above haemostatic composition involves the dry heat treatment at temperature 110 to 200°C.

EFFECT: compositions exhibit the enhanced haemostatic properties.

68 cl, 1 tbl, 8 ex

Wound tissue // 2483755

FIELD: medicine.

SUBSTANCE: invention refers to medicine, to preparing a therapeutic and preventing agent for treating radioreactions accompanying the course of radiotherapy. A wound tissue contains a textile fibre-porous material with a viscose component coated with a polymer and a drug preparation introduced therein; the novel is the fact that it is suggested to use the textile material which is made of flax-viscose fibres in ratio of components of flax:viscose 40 - 70 and 60-30, respectively. The fibre-porous material is prepared by needle suturing and has area density 180 g/m2 - 260 g/m2. The coating polymer is sodium alginate, while the drug preparation is introduced in the concentration of 0.25-30 wt %. The drug preparation coating the suggested flax-viscose carrier is presented by poorly soluble preparations of Furaginum, metronidazole, 5-fluoruracil, antioxidant Mexidol, biologically active substances - propolis, sea buckthorn and blackberry extracts.

EFFECT: presented drug preparation has proved itself to be easy to use, enabling higher clinical effectiveness, increasing a prolongation time.

6 ex

FIELD: medicine.

SUBSTANCE: present invention refers to medicine, particularly to a method for making hydrogel wound dressings of polyvinylpyrrolidone or its monomer, agar, distilled water, ethylene or propylene, polyglycols, silver using ionising radiation wherein a complex of cationic polysaccharide, preferably chitosan, and silver is prepared by mixing AgNO3 with chitosan powder characterised by an average molecular weight of 40000 to 200000, previously degraded by irradiation with beam energy 10 MeV; the deposition is filtered, washed with distilled water and added to a mixture consisting of, wt %: 2-10% of polyvinylpyrrolidone or monomer, max. 5% of agar, at least 75% of distilled water and 1-3% of ethylene or propylene polyglycols, and gel prepared thereby is cross-linked by ionizing radiation of a dose of 20-30 kGy, preferentially 25 kGy.

EFFECT: provided high biological activity and long effective use of surgical dressings.

3 cl, 6 ex

FIELD: medicine.

SUBSTANCE: composition of forming solution for formation of biopolymeric fibres includes polyethylene oxide, chitosan, organic acid and water. Or composition of forming solution for formation of biopolymeric fibres includes chitosan, water and component, selected from polyethylene oxide, polyvinyl alcohol or polyvinylpyrrolidone. Chitosan with molecular weight 30-40 kDa and polyethylene oxide with molecular weight 2000-8000 kDa are used. Composition additionally contains cellulose diacetate and biologically active substances. Method of forming solution preparation includes mixing of components in powder-like state and their dissolution with mixing to homogenous state. Linen of biomedical purpose, formed from biopolymer chitosan-based fibres, in order to obtain from it bandage for wound treatment, is subjected to swelling in physiological solution or distilled water. Additionally linen of biomedical purpose is subjected to thermal processing, after which it is placed into distilled water or physiological solution for swelling. Or linen is additionally processed with alkaline reagent, with further washing with distilled water, after which it is placed into distilled water for swelling. For wound treatment linen of biomedical purpose is applied on wound in form of biological bandage.

EFFECT: invention makes it possible to obtain biopolymer fibre with application of optimal compositions of textile composition based on chitosan and non-toxic polymer for stable electroformation of defect-free fibres, methods of modification of linen of biomedical purpose for obtaining bandage in form of wound covering are ecologically clean and economical.

2 tbl, 73 ex, 5 dwg

FIELD: medicine.

SUBSTANCE: agent contains chitosan salt 75-95 wt % of polydisperse powders of chitosan hydrochloride, hydrobromide, formate, acetate, succinate, citrate, glycolate or lactate and polyhexamethylene guanidine hydrochloride 4-20 wt %. The chitosan salt and polyhexamethylene guanidine hydrochloride are covalently cross-linked by a polyfunctional compound 1-5 wt % of glycidyl ethers. The chitosan salt is specified with an average particle size of 0.2÷2.0 mm, degree of chitosan deacetylation 0.75÷0.95, and molecular weight 10÷500 kDa. The above polyfunctional compound of glycidyl ethers is presented by a diglycidyl ether of butandiol, di- or triethylene glycol or propylene glycol, oligoethylene oxide, as well as triglycidyl ethers of glycerol or trimethylol propane.

EFFECT: method possesses high blood sorption capacity, rapid hemostasis time and high antimicrobial activity.

3 cl, 2 tbl, 12 ex

Up!