Diagnostic technique for disturbed vegetative regulation of heart rhythm in children with gastrooesophageal reflux disease
SUBSTANCE: intraoesophageal pH monitoring and Holter monitoring are recorded daily. The heart rate variability is estimated in the aggregate with an analysis of a nocturnal heart rate trend. If finding more than 5 episodes of high heart rate dispersion coinciding with reflux episodes, or if a nocturnal structure comprises more than 50% of the episodes, the disturbed vegetative regulation of heart rhythm related to gastrooesophageal reflux disease is diagnosed.
EFFECT: technique enables diagnosing the extra-oesophageal manifestations of gastrooesophageal reflux disease at the early stage of the disease after the subjective manifestations have been observed.
The invention relates to medicine, namely to Pediatrics.
Clinic gastroesophageal reflux disease (GERD) is the sum of esophageal and extraesophageal symptoms. Adults to extraesophageal symptoms of GERD include, in particular arrhythmia. In children with GERD arrhythmia detected relatively infrequently, however, there are disorders of autonomic regulation of heart rhythm, which may be associated with the implementation of esophagojejunal reflex during pathological reflux. Without correction of vegetative status cannot complete treatment of GERD in children.
A known method for the diagnosis of autonomic cardiac neuropathy in children with diabetes mellitus [Ivanov D.A., Gosev SF Method for early diagnosis of autonomic cardiac neuropathy in children with diabetes mellitus type I // Patent for the invention №2218864, Moscow, 2003]. During Holter monitoring is temporal and spectral analysis of heart rhythm, as well as trend analysis of heart rate (HR) during a night's sleep. Counts the number of periods of high variance (TTD) heart rate and the percentage of time that the DPP occupy in the structure of sleep a night. However, an increase in periods of high dispersion curves more than 5 episodes or more than 50% of the night's sleep was regarded as expressed vegetative down-regulation de the activity of the heart and an early sign of autonomic cardiac neuropathy. The disadvantage of this method is: use only in children with diabetes and only in the diagnosis of autonomic cardiac neuropathy; the failure time of the DPP with clinical manifestations of the underlying disease.
As the closest analogue (prototype) the selected method for the diagnosis of autonomic disorders in children with gastroesophageal reflux disease [Ivanov I.I., Gosev SF Features of the functioning of the autonomic nervous system in children and adolescents with acidic and alkaline gastroesophageal-reflux // Pediatrics. - 2010. No. 2. - P.17-23], which is associated with carrying out daily monitoring intraesophageal pH and Holter monitoring. It is shown that in children with acidic and alkaline gastroesophageal-reflux (compared to physiological change indicators of temporal and spectral analysis of heart rhythm. According to the simultaneous monitoring of pH and ECG revealed parallelism in the change in the spectral indices of the rhythm and the occurrence of acid reflux. The disadvantage of this method is that for the assessment of autonomic homeokinesis used indicators of temporal and spectral analysis of rhythm, which are calculated automatically by the program, and therefore, the possible error due to the frequent presence of children is of refacto. Also, do not use all the diagnostic possibilities of the method Holter monitoring.
The objective of the invention is to develop a method, which will reveal the instability of heart rhythm associated with impaired autonomic regulation due to GERD.
The problem is solved due to the fact that in the method for the diagnosis of impaired autonomic regulation of heart rhythm in children with gastroesophageal reflux disease, including daily monitoring intraesophageal pH and Holter monitoring with measurement of heart rate variability, has the following differences: advanced analysis of the trend of the heart rate during sleep at night by counting the number of episodes of PPD and their percentage in the structure of sleep a night.
The essence of the proposed method lies in the fact that the increase in the representation of the DPP more than 5 episodes or more than 50% during the night's sleep is a marker of impaired autonomic regulation of heart rhythm. The periods of instability of heart rhythm associated with the presence of pathological gastroesophageal reflux and may be predictors of arrhythmias. Their identification requires dynamic monitoring of the functional state of the cardiovascular system in children with GERD.
Between the combination of the substantial characteristics of the proposed facility and achievable technical result there is a causal relationship, namely, the increase in the representation of the DPP more than 5 episodes or more than 50% during the night indicates the presence of impaired autonomic regulation of heart rhythm in children with GERD.
New features of the claimed method for the diagnosis of impaired autonomic regulation of heart rhythm in children with gastroesophageal reflux disease are:
1) expand diagnostic capabilities Holter monitoring - the use of trend analysis heart rate during sleep at night,
2) identify early signs of instability of heart rhythm in the absence of severe clinical symptoms of cardiovascular system in patients with GERD
3) identification of communication episodes TTD with the presence of pathological gastroesophageal reflux according to the daily pH-metry.
The method is developed based on the analysis of daily monitoring intraesophageal pH and Holter monitoring 69 children with GERD and 48 children with chronic gastroduodenitis. The diagnosis of GERD is exhibited on the basis of the clinical picture and confirmed by instrumental data. The study found that in children with GERD time episodes TTD in total amounted to 304 (240-354) minutes (indicated by the median and the interquartile scale), and in children with chronic gastroduodenitis - 252 (202-294) minutes (the difference statistician who Cesky significant p=0,021). Time TTD from the entire period of sleep was in children with GERD 58,0 (48,0 is 65.5)%, and in children with chronic gastroduodenitis - 46,8 (43,1-50,6)% (difference is statistically significant, p=0.002). Thus, when GERD have more severely impaired autonomic regulation of heart rhythm.
The proposed method for the diagnosis of impaired autonomic regulation of heart rhythm in children with gastroesophageal reflux disease is carried out in the following sequence:
When conducting daily monitoring intraesophageal pH and Holter monitoring conduct simultaneous analysis of reflux episodes and the RPE. Count the number of TTD and interest of their contents in the structure of sleep a night. If you have more than 5 episodes of the DPP or more than 50% of their representation in the structure of sleep talking about the violation of vegetative regulation of heart rhythm. At the same time pathological gastroesophageal reflux and Beijing believe that the instability of the heart rhythm is associated with reflux episodes. Clinical example.
Michael S., age 16. The diagnosis of GERD exhibited a year ago, the gastroenterologist is observed with 8-years of age. The main complaint at the time of the survey is heartburn. Clinical signs of GERD are supported by the data daily pH-metry: sour pathological reflux of 2 degrees. Signs of autonomic dysfunction neveragain, clinically determined atonia. According to kardiointervalografii - vagotonic with Hyper sympathicotonic reactivity. By Holter monitoring heart rate from 50 to 154 per minute during the day and from 53 to 88 per minute at night. Circadian index of 1.41 (within normal limits). Spectral analysis showed that the high-frequency component is only 8,8% of the total spectrum, despite the fact that during the whole day and night was periodically determined aetiology. The low-frequency component amounted to 22.2%, a component of very low frequencies - 68,9%. Index vagosympathetic interaction 2,52, the index of centralization of 0.45. These data suggest the involvement in the regulation of sympathetic autonomic nervous system and confirm the results of the WHALE on the availability of vagotonia with Hyper sympathicotonic reactivity. When analyzing the trend of the heart rate during sleep was determined to be only three periods of high variance, however, their total duration was more than half the night time. Identified violations sleep patterns, which in time are associated with the presence of night time acid reflux (according to the daily pH-metry), subjectively not weary child. In this case, we can conclude that the instability of heart rhythm associated with GERD. A comprehensive therapy and observation.
Thus, the image is eenie allows you to extend the diagnostic capabilities of Holter monitoring in the diagnosis of impaired autonomic regulation of heart rhythm in children with GERD, to establish the existence of unstable heart rhythm and to monitor the functional state of the cardiovascular system in patients.
A method for the diagnosis of impaired autonomic regulation of heart rhythm in children with gastroesophageal reflux disease, including daily monitoring of intraesophageal pH and Holter monitoring, wherein the heart rate variability assessed in conjunction with trend analysis of heart rate during sleep at night and if more than 5 episodes of periods of high variance in heart rate, coinciding with episodes of reflux, or their percentage representation of more than 50% in the structure of sleep at night diagnose violation of vegetative regulation of heart rhythm associated with gastroesophageal reflux disease.
SUBSTANCE: invention proposes a detection method of proteins in amyloid state, in which a specimen of lysate of yeast culture or tissue of a mammal is obtained, ionic detergent is added to the specimen, proteins are concentrated in an amyloid shape on a cellulose acetate membrane, and they are detected by means of aptomeres, their conjugates or antibodies specific to amyloid shape of proteins. Besides, a set for detection of proteins in amyloid state is proposed.
EFFECT: invention can be used in medicine for diagnostics of amyloid diseases.
9 cl, 6 dwg, 7 ex
SUBSTANCE: invention relates to medicine, particularly to paediatrics. If ionised blood serum calcium is less than 0.9 mmole/l and the relation of ionised Ca/inorganic phosphorus is 0.3 or more, calcium gluconate 1.0 ml is introduced intramuscularly 7-10 times/day in a combination with the oral administration of 10% calcium chloride 5.0 ml 7-10 times/day and 0.5% alcohol solution of vitamin D2 8000 IU a day. If observing comorbid hypomagnesaemia (Mg below 0.66 mmole/l), 25% magnesium sulphate 1 ml is introduced intramuscularly once a day. If the calcium level is less than 0.9 mmole/l and the relation of ionised Ca/inorganic phosphorus is less than 0.3 instead of vitamin D20, Parathyreoidin 25-0.5 ml is administered intramuscularly 3 times a day. If ionised calcium is more than 1.1 mmole/l and magnesium is more than 0.66 mmole/l, 10% calcium chloride 5.0 ml is orally administered 7-10 times a day, and vitamin D2 8000 IU a day or substituting Parathyreoidin in a dose of 0.25-0.5 ml 3 times a day intramuscularly. After the calcium and magnesium levels are stably normalised, Parathyreoidin is replaced by 0.5% alcohol solution of vitamin D2.
EFFECT: using the method enables eliminating hypocalcemia considerably faster, recovering normal blood 25(OH)D that prevents recurrent convulsions.
2 tbl, 2 ex
SUBSTANCE: disclosed is a method of detecting urine, which involves: using a urine sensor having a matrix, the matrix containing a thermochromic substance distributed therein and a temperature varying means, where said temperature varying means is capable of either raising temperature or lowering temperature upon contact with urine so as to cause temperature change in the thermochromic substance, resulting in colour change; contacting the urine with the sensor matrix; and determining presence of urine based on colour change of the thermochromic substance. A sensor for determining presence or absence of urine is also disclosed.
EFFECT: high accuracy and reliability of detection.
11 cl, 7 ex, 2 dwg
SUBSTANCE: oral fluid is examined for the concentrations of mineral elements. A calcium/magnesium ratio is calculated, and if the value is 4.8-8.3, an increase of the saliva cadmium concentration and a propensity for developing chronic generalised periodontitis; the ratio of 8.4 and more, chronic generalised periodontitits is diagnosed if the saliva cadmium concentration exceeds 0.61 mcg/l.
EFFECT: higher diagnostic accuracy of chronic generalised periodontitis.
SUBSTANCE: newborn's umbilical blood is examined for a level of endogenous nitrite, blood flow between aortic cusps, blood flow between pulmonary artery cusps, systolic blood pressure; diagnostic indexes F1 and F2 are calculated by formulae: F1=34.06*ABF+0.89*SBP+65.96*PBF-0.43*NOE-74.67 F2=26.29*ABF+0.73*SBP+54.74*PBF-0.15*NOE-51.45 wherein NOs is the level of endogenous nitrite in umbilical blood (mcmole/l); ABF is blood flow between aortic cusps (m/s); PBF is blood flow between pulmonary artery cusps (m/s); SBP is systolic blood pressure (mm Hg). If F1 is more than F2, posthypoxic cardiopathy is predicted, while F1 less than F2 shows the absence of risk of developing cardiopathy.
EFFECT: use of the method provides predicting the neonatal cardiovascular disorders by non-invasive methods in newborns delivered by mothers suffering congenital cardiac failures.
SUBSTANCE: non-stimulated oral fluid is collected on an empty stomach and analysed for the concentrations of sodium, potassium, calcium, phosphorous and lactic acid bacilli. The relations Ca/P and Na/K are calculated. The values Ca/P 0.63, Na/K 1.2 and lactic acid bacilli count 103-104 enables diagnosing a risk of caries and inflammatory diseases of periodontium tissues; the values Ca/P 1.3, Na/K 0.9 and lactic acid bacilli count 105-106 enables diagnosing a risk of developing caries and no risk of inflammatory diseases of periodontium tissues; while the values Ca/P 1.1, Na/K 1.2 and lactic acid bacilli count 105-106 provides diagnosing a risk of caries and inflammatory diseases of periodontium tissues.
EFFECT: technique enables accurate diagnosis of a risk of developing caries and inflammatory diseases of periodontium tissues in screening programs.
SUBSTANCE: content of sodium, potassium, calcium, ratio of sodium concentration to content of potassium in saliva of examined person are determined. If calcium content is more than 0.07 g/l and value of Na/K ratio is 0.12 and less -diabetes mellitus of 2-nd type is diagnosed.
EFFECT: method application allows to increase efficiency of diagnosing diabetes mellitus of second type.
3 tbl, 1 ex
SUBSTANCE: milled samples of biological material are poured with physiological solution for 24 hours at room temperature, filtered through wadding, centrifuged for 20 min at 3-4 thousand revolutions per minute. After that 1.5% solution of lauryl sulphate per 1.5% solution of caustic soda is added to sediment, kept for 20 minutes, centrifuged for 20 minutes at 3-4 thousand revolutions per minute, sediment is washed with physiological solution 2-3 times and inoculated on nutrient medium.
EFFECT: application of method allows to optimise pre-inoculation processing of biomaterial, and increase efficiency of bacteriological diagnostics of tuberculosis.
1 ex, 1 tbl
SUBSTANCE: invention relates to medicine, in particular to urologic diagnostics and is intended for evaluation of prognosis of unilateral or bilateral stone formation development. Laboratory test of patient's urine is performed, by results PHU, MGU, R% and CH CAOX are obtained and linear classification discriminant functions are calculated by the following formulae: F1=-2076.27+22.89* PHU-9784.25* MGU+41.33* R%-2.76* CH CAOX, F2=-2068.17+23.82* PHU-9952.00* MGU+41.20* R%-2.98* CH CAOX, where: F1 - first classification discriminant function corresponds to group of patients with unilateral affection of kidneys, F2 - second discriminant function corresponds to group of patients with bilateral affection; PHU - pH of urine; MGU is concentration of urine magnesium, mole/l; R% is relative tubular reabsorption, %; CH CAOX is degree of urine saturation with calcium oxalate. After that obtained values of the first and second discriminant functions are compared, function whose value turns out to be higher, points to patient's belonging to corresponding group of patients.
EFFECT: method ensures increase of accuracy of unilateral or bilateral nephrolithiasis development.
1 dwg, 4 tbl, 2 ex
SUBSTANCE: prediction of increasing the functional class of chronic cardiac failure (FC CCF) within the next year is ensured by determination of serum magnesium in blood serum (mmol/l) (XI), potassium of blood serum (mmol/l) (X2) and encephalic natriuretic peptide (pg/ml) (X3), observed diastolic dysfunction of left ventricle (LV) (1 - shown by cardiac ultrasound; 0 - not shown) (X4), high-grade ventricular premature beats (1 - shown by cardiac electrocardiogram; 0 - not shown) (X5) and cardiac fibrillation (1 - shown by cardiac ultrasound; 0 - not shown) (X6). The probability is calculated by formula Prob (event)=exp(eta)/(1+exp(eta)), where Prob (event) is probability of CCF progression, eta=-0.332674+2.12648*X1+6.34589*X2-0.00574387*X3+3.38776*X4=1-0.574371*X4+2-3.01702*X5=0; if Prob (event) is equal to 0, increasing the functional class is not expected; if Prob (event) is equal to 1, increasing the functional class by one unit is observed.
EFFECT: application of the method allows improving effectiveness of prediction of chronic cardiac failure progression.
SUBSTANCE: invention relates to medical equipment. An ECG monitoring system for detecting infarct-related coronary artery associated with acute myocardial infarction comprises the number of electrodes for data collection by electrical cardiac activity from various observing points spaced from the heart. An ECG data collection unit is related to the electrodes. An ECG processor responses to electrode signals to form a set of lead signals and detects ST rises in the lead signals. The display responses to the detected ST rises and graphically displays each set of the given ST rise in relation to the anatomical positions of the leads. The graphical display identifies the suspected infarct-related coronary artery or branch associated with acute ischemic stroke. The ECG signals is n-leads are received. The ECG signals are analysed for the consistency with the ST rise data. The each set of ST rises is graphically displayed in relation to the anatomical body positions. The stages of receiving and analysing are repeated some time later. The each set of ST rises derived some time later are graphically displayed and compared to the previous displayed ST rises. A comparative graphic display is used to display the time variation of a coronary disease symptom associated with the specifically identified coronary artery or branch.
EFFECT: using the invention enables reducing the length of diagnosing.
15 cl, 18 dwg
SUBSTANCE: invention relates to medicine, namely to cardiology. ECG examination is performed to patient. Registration of signal-averaged ECG and transesophageal electrocardiostimulation (TE ECS) are carried out. Duration of filtered wave "P" (FiP-P) of signal-averaged ECG, dispersion of wave "P" (Pd), frequency threshold of arrhythmia induction (FTAI) and its duration are determined by means of TE ECS, risk of atrium fibrillation development (RAFD) being determined by original mathematical formula. If RAFD values are to 0.5, high during 1-3 months risk of AF development is identified. If values are from 0.5 to 1.5 - average from 3 months to 1 year risk of AF development. If values are higher than 1.5 - low, more than 1 year risk of AF development is identified after the first examination of patient.
EFFECT: method increases accuracy of determining risk of AF development after the first examination due to analysis of interaction of ECG and TEECS indices.
5 tbl, 4 ex
SUBSTANCE: invention refers to medicine, specifically surgery and functional diagnostics. The supine heart rate is recorded and represents a baseline test, while the standing heart rate measured is an orthostatic test for 30 sec. The regulatory system activity index (RSAI) is described in points 1 to 10. An increase of this value relates to the deteriorating body adaptive possibilities; the RSAI value of 3-10 points enables predicting the postoperative wound complications.
EFFECT: method enables predicting the postoperative complications following the replacing hernia repair for postoperative hernias.
4 dwg, 3 tbl
SUBSTANCE: invention relates to medicine, particularly endocrinology and diabetology. There are involved examining heart rate variability (HRV) followed by spectroscopic analysis and functional testing. Those are added with determining non-linear values: deterrent fluctuation analysis (DFA) and approximated entropy (ApEn). If observing the initial amplitude decay of the HRV spectral components - VLF less than 30 points, LF less than 15 points, HF less than 15 points, DFA more than 0.7, ApEn less than 180, lack of functional response - autonomic cardiac sympathovagal neuropathy is diagnosed. If observing the normal amplitude of the HRV spectral component -VLF more than 30 points, low LF values less than 15 points, HF less than 15 points, DFA more than 0.7, ApEn less than 180, lack of functional response LF, HF - autonomic cardiac vagal neuropathy is diagnosed. If observing the initially normal amplitudes of the HRV spectral component -VLF more than 30 points, LF more than 15 points, HF more than 15 points, DFA more than 0.7, ApEn more than 180, lack of functional response LF, HF - autonomic cardiac subclinical neuropathy is diagnosed.
EFFECT: method enables early diagnosing and typing of autonomic cardiac neuropathy for the purpose of specifying a therapeutic approach.
3 tbl, 3 ex
SUBSTANCE: invention relates to medicine, namely to neurology, therapy, family medicine, and can be used for selection of tactics for treatment of tension headache. For this purpose level of peripheral heart vegetative balance is determined in patient by analysis of index of sympathetic-parasympathetic relationship (LF/HF) in spectral analysis of cardiac rhythm. If LF/HF index increases higher than 2.0 conv. units, psychotropic drugs are introduced into therapy for relief of anxiety and/or depression.
EFFECT: method ensures possibility to stratify patients, requiring introduction of psychotropic drugs, thus making it possible to optimise treatment and increase its efficiency due to account of individual peculiarities of heart vegetative balance.
3 tbl, 2 ex
SUBSTANCE: invention relates to field of medicine, namely to neurology and hepatology. Multi-level neurodynamic analysis of cardiorhythmograms is registered and realised by means of rhythmocardiograph and hardware and software complex "Omega-C". Determined are indices, reflecting: "A" - association of all, but mainly peripheral rhythmic processes, "B1" - degree of equilibration of sympathetic and parasympathetic effects on sinus node of heart, "C1" - state of central subcortical regulation, "D1" - state of central cortical regulation. Diagnostics index (YHE-L) is calculated in patients with chronic liver diseases by formula: YHE-L= -1.5 + 0.003*A + 0.013*B1 + 0.006*C1 + 0.053*D1. If YHE-L value is from -0.47 to 0.49, hepatic encephalopathy of latent stage in patients with chronic liver diseases is determined.
EFFECT: method makes it possible to increase reliability of diagnostics of hepatic encephalopathy of latent stage.
8 tbl, 2 ex
SUBSTANCE: invention refers to occupational medicine. Individual state and performance values are estimated by four-score scale. Zero points if no symptoms observed, 1 point - the symptom is slightly manifested, 2 - moderately, 3 - significantly. A fatigue index (FI) is calculated as an arithmetic mean value. Electrocardiography is recorded to estimate cardiac rhythm variability, to calculate Am, Si, LF, heart rate. A modification coefficient (M) is calculated for each value by formula: wherein Ai is a value of one of the following signs, Amax and Amin are change ranges; : Am min 3.5, Am max - 98; Si min - 2, Si max - 950; LF min - 5, LF max - 90; heart rate min - 40, heart rate max -120; a vegetative regulation index (VRI) is calculated by formula: If the FI value is 0.6 points or less, and the VRI value is 10 or less, the state is considered to be optimal; the FI value 0.6 points or less and the VRI value more than 10 show the borderline state; the FI value more than 0.6 points and the VRI value is 10 or less means the satisfactory state; while the FI value exceeding 0.6 points and the VRI value exceeding 10 providing stating defatigation.
EFFECT: method extends the range of products for detecting defatigation in operators.
7 tbl, 2 ex
SUBSTANCE: invention refers to medicine, namely cardiology, normal physiotherapy, pathological physiotherapy. A daily curve of blood pressure is recorded. It is followed by spectral analysis by the method of continuous wavelet transformation. A frequency power of the blood pressure curve a is determined in the moment b by mathematical formula. Scalograms are drawn on the basis of the wavelet coefficient on the segment [bj, bj] by mathematical formula. Physiologically relevant frequency ranges are selected at the scalograms on the basis of distances between adjacent local minimums on the scalogram curve by formula.
EFFECT: method provides weak influence of vegetative nervous system and humoral effects on the blood pressure curve at the various stages of ontogenesis, in health and disease, both in rest, and in transition processes.
1 ex, 2 dwg
SUBSTANCE: invention refers to rehabilitation and preventive medicine, cardiology, therapy. It involves drug-induced therapy and a course of cardiorespiratory training with biological feedback (BF) presenting a cardiorhythmography (CRG) and a reference cyclic curve (RCC) to the patient to be matched under continuous visual control. It is followed by active (BF-assisted) and non-active (BF-unassisted) 2-minute tests with the first and last test of each session are non-active (NT). The first NT involves recording reference data of patient's cardiorespiratory system with evaluating the parameters as follows: RCC amplitude, period and continuous component matched with average heart rate on the following active test (AT). The test are automatic, individual for the patient as for the moment of testing with the use of an apparatus for functional psychophysiological correction comprising units described in the patent claim. Each following AT requires forming RCC with the use of average heart rate, amplitude and period on the basis of spectral analysis of CRG and CC of the previous AT. In the beginning of the procedure, the patient is set up to successful completion of the task, 5 s after the beginning of each AT, an audio signal (1 kHz, 300 ms, 30 dB above a threshold of audibility) is supplied. Before the beginning of the course and after each session and the whole course, the patient is tested to determine a level of reactive and personal anxiety and depression by stating the required number of sessions for recovery of cardiorespiratory synchronisation and normal heart rate and blood pressure. Before the first NT and after each AT, capnometry is used to determine the concentration of CO2 in expired air. If observing decrease, respiratory depth is corrected. If maintaining CO2 in expired air after each following AT less than 95% from reference, respiratory depth is corrected during the following AT under control of capnometry to achieve the concentration of not less than 95% from reference. The therapeutic course includes at least 5 sessions, 1 session daily or every second day to recover the respiratory pattern lost due to the disease and the biorhythmological structure of heart rate.
EFFECT: method eliminates subjectivity of the respiratory parameters specified by a searcher, and hyperventilation syndrome due to objective control of respiratory depth with improved heart rate variability.
1 ex, 3 tbl, 3 dwg
SUBSTANCE: group of inventions relates to medicine and medical equipment, namely, to systems of image obtaining, in particular, to computed tomography. In first version of implementation system of image obtaining contains component of window management, which receives ECG signal, which contains premature cardiac cycle and preliminarily obtained X-ray projection data of beating heart. ECGF signal is synchronised with the time of preliminarily obtained X-ray projection data of beating heart. Component of window management places first reconstruction window within the limits of the first cardiac cycle to correspond desirable cardiac phase of preliminarily obtained X-ray projection data, when premature cardiac cycle ensures correspondence of the first reconstruction window to another cardiac phase. Such system contains device of reconstruction which reconstructs projection data, corresponding to multitude of windows of reconstruction of different cardiac cycles to create image data, characteristic of desirable heart phase. In second version of implementation system contains component of window management which deletes first reconstruction window corresponding to suboptimal cardiac phase of preliminarily obtained X-ray projection data of beating heart resulting from abnormal signal in ECG signal. ECG signal is presented in time with preliminarily obtained X-ray projection data of beating heart on multitude of heart cycles, and component of window management adds replacing reconstruction window to optimise set of data for reconstruction, basing on abnormal signal and available preliminarily obtained projection. System also contains reconstruction device which reconstructs set of data for reconstruction in order to create image data characteristic of desirable phase of heart beating. In third version of implementation system contains recommendation component which recommends reconstruction window for cardiac phase within the multitude of preliminarily obtained successive cardiac cycles based on ECG signal and arrhythmia in it, and device of reconstruction, which reconstruct data corresponding to data for each cycle, corresponding to reconstruction window. ECG signal is obtained with simultaneous scanning of beating heart by of computed tomographic scanner. In fourth version of implementation system contains component of window management which automatically changes location or moves first window of reconstruction for cardiac cycle on the basis of premature cardiac cycle within ECG, which is signal synchronised with preliminarily obtained X-ray projection data of beating heart; recommendation component which automatically recommends, at least, one additional reconstruction window, on the basis of premature cardiac cycle; and reconstruction device which reconstructs data, corresponding to reconstruction windows. In order to obtain image received is ECG signal which contains premature cardiac cycle, ECG signal is synchronised in time with preliminarily obtained X-ray projection data of beating heart by multitude of cycles of heart beating. After that, first reconstruction window is moved within the limits of first cardiac cycle, which corresponds to data, different from desirable cardiac phase as a result of premature cardiac cycle. Each from multitude of cardiac cycles contains reconstruction window. Then preliminarily obtained projection data, corresponding to multitude of reconstruction windows, are reconstructed to create image data, characteristic of desirable phase of heart beating. Group of inventions also contains computer-readable data carrier, which stores commands, which, when performed by computer, make computer perform claimed method of image obtaining.
EFFECT: application of claimed group of inventions will make it possible to increase quality of resulting data of reconstructed image.
34 cl, 10 dwg
FIELD: medicine, cardiology.
SUBSTANCE: one should register rhythmocardiogram, measure current total power in low-frequency and high-frequency areas of dynamic row of cardiointervals. Evaluation of psychophysiological state should be performed by the value of stress index S calculated due to original mathematical formula by taking into account the power of low-frequency and high-frequency constituents of the range of dynamic row of cardiointervals. In case of standard conditions of measurement - the rest lying at one's back position the value of S stress index should be considered to be equal to 1. The method enables to rapidly and noninvasively detect and range human psychophysiological state.
EFFECT: higher accuracy of evaluation.
2 dwg, 1 ex, 2 tbl