Method for assessing light exposure on functional status of human brain

FIELD: medicine.

SUBSTANCE: invention refers to medicine and may be used for assessing the light exposure generated by a light-emitting-diode source on the functional status of human brain cortex. The white light exposure covers individual's open eyes at colour temperature 1700-10000 °K, illumination 80-300 lx at the eye level. That is followed by electroencephalogram recording and spectral analysis. If observing an increase or a decrease of alpha or teta wave spectral power by more than 25% of a baseline value, the light exposure is considered to be physiologically active, and by less than 25% - as physiologically neutral.

EFFECT: method provides more reliable assessment of the functional status of human brain that is ensured by biological activity rating within the alpha and teta wave range.

4 tbl, 4 ex

 

The invention relates to medicine and can be used to assess the impact on the functional status of a person by light radiation from the led source.

Currently, there is a wide spread of new light sources based on light-emitting diodes. Such semiconductor light sources have not only incredibly powerful, but if they are built on the principle of RGB mixing) and the ability to vary the quality (color, range), quantitative (intensity) and modulation (frequency of outbreaks) light parameters for a given algorithm. This quality is called "intellectual light".

The closest in technical essence and the achieved result is a way of assessing the impact on the functional state of a human light radiation (Martirosov V.G. and other "Physiological-hygienic estimation of radiation of led light sources". RBM. Turns Probl. Medicine". 2011, 26, 2, p.27-34).

The disadvantages of this method is the lack of information content and reliability of the assessment of the impact on the functional state of the human brain by light radiation.

The technical result, which directed the present invention is to improve the information content, accuracy and and reliability of the impact assessment of the functional condition of the person of light from an led source.

This technical result is achieved in that in the method of assessing the impact on the functional state of the human brain light radiation, including the effects of white light from the led light source according to the invention, the effects of exercise on the open eyes of a person with white light with a color temperature of 1700-10000 K, the illuminance at eye level 80-300 LK, record the electroencephalogram, conduct its spectral analysis and the increase or decrease in the spectral power of alpha or theta rhythm by more than 25% of the background values in most derivations light exposure estimate as physiologically active, and less than 25% of a physiologically neutral.

Conducted investigation of effects on the functional state of the human brain dynamically managed ("intellectual") of light from a semiconductor source with a color temperature varied in the range from warm 1700 to cool To 10000 K shades of white light.

Spectral analysis of EEG objectively possible to have change the main rhythms of electrical activity in the brain when exposed to light with variable color temperature.

In the course of the study tested a prototype of an led source of intellectual light is a, managed with the help of special software. The luminous flux of the light source depending on the color temperature was 1000-4000 LM. Color temperature of white light had changed and set temperature in the range 1700-10000 K. the color rendering Index for these color temperatures lying in the range of 80-90.

During the exposure of white light with various color temperatures were recorded electrical brain activity of the subject. The study involved 20 people ranging in age from 17 to 47 years (9 women, 11 men). The EEG recording was performed with an electroencephalograph "Telepathy-D" (, St. Petersburg) monopolar method according to the international system "10-20" points Fp1, Fp2, F3, F4, C3, C4, P3, P4, O1, O2, F7, F8, T3, T4, T5 and T6 by the indifferent electrodes placed on the earlobes. The sampling rate of the signals was 250 Hz, the bandwidth of the high frequency of 35 Hz, the time constant of 0.3 C.

As a control condition was used EEG with open eyes in dim light conditions of the room. Next subject, remaining with open eyes, were subjected to sequential exposure to 5 choices of lighting, different preset color temperature of the led source. The duration of recording in the background and samples with different swedenrockfestival 2 min in each case, the intervals between exposures of light also had a duration of 2 minutes

The study obtained data was carried out visually and by means of spectral analysis. Determined values of the spectral power of alpha, theta, Delta and beta rhythms in all recorded areas of the cerebral cortex in all the stages of registration of brain activity. Spectral analysis was carried out using electroencephalographic program WinEEG Version 1.3". Epoch analysis in the calculation of the spectra was 4 C. the Average spectral indices were calculated for the entire duration of recording in the background and EEG during exposure to light samples.

When statistical processing of obtained results was calculated the average values of the analyzed characteristics, their standard deviation, standard error of the mean. Determination of the degree of reliability of the differences between averages were performed in the statistical software package Statistica 6" at the level of p<0.05 using Wilcoxon criterion.

Visual analysis of EEG dynamics during expositions of white light with variable color temperature showed the presence of mixed reactions in the group examined in the light from the led source. In some cases, there has been a visible increase in the representation of α-rhythm and strengthening its re is warnotte, which corresponds to an increase in the stability of the overall functional state of the brain, while others, conversely, reduced expression of alpha-rhythm with a tendency to transition from the constant activity to episodic outbreaks and irregular waves.

Spectral analysis of EEG allowed to objectively evaluate changes in the basic rhythms of electrical activity in the brain when exposed to light with variable color temperature. Most notable are two types of changes in the EEG. It was noted any increase in the spectral power of the alpha rhythm and a small but significant increase in the power of theta, Delta rhythms on a number of leads, or the reducing power of the alpha rhythm and a moderate decrease in the power of theta rhythm. It should be emphasized that both types of reaction to light exposure was determined by the dynamics of alpha and theta rhythms, changes in the spectra of the Delta rhythm joined in only one type of reaction. Any significant impact imposed on the light on the power of beta rhythms are not apparent. Thus, the main criteria for exposure to light can be considered an increase or decrease in spectral power it is the alpha and theta rhythms.

The method of assessing the impact on the functional state of the human brain, and light emission is illustrated by examples.

Example 1.

In the group of 1 people with an average age 30.80±3.21 years (3 women and 7 men) were exposed to white light with a color temperature of 10000 K for 120 s, this was done by registration of the EEG. Calculated spectral power of alpha and theta rhythms.

The rate of change of the averaged spectral power of alpha and theta rhythms under the influence of the light relative to the background values of the indicators in the state of quiet wakefulness shown in table 1. Average EEG spectral power increased by more than 25% in the range of the alpha rhythm in all leads and in the range of theta rhythm in most leads. In part these derivations significant increase (p<0.05 using Wilcoxon criterion); - relevant trends. In General, the detected level of changes in the spectral power of alpha and theta rhythms in excess of background values by more than 25%, confirms the influence of light with 10000 K on the functional state of the human brain, and therefore, this light effect is physiologically active.

Table 1
Changes in spectral power of alpha and theta rhythms when exposed to light with a color temperature of 10000 K
Leadα-rhythmθ-the ITM % change
BackgroundLightBackgroundLightα-rhythmθ-rhythm
Fp16.22±1.7218.39±2.233,11±0,674,69±0,9334,9050,87
Fp25.51±1.628.39±2.01*3,00±0,653,97±0,7452,3232,68
F37.29±2.259.99±2.783,26±0,684,63±0,74*37,1242,23
F46.14±1.799.40±2.00*3,31±0,633,71±0,4153,0212,17
C37.74±2.2712.02±3.862,91±0,463,98±0,54*55.2637,01
C47.19±2.03http://10.96i2.76±2,96±0,593,22±0,3152,358,88
P39.4±3.4118.55±6.67*2,71±0,443,66±0,5997,2334,86
P47.87±2.30http://14.29ib3.73*±2,83±0,523,03±0,3181,467,15
O112.84±5.35At 25.52±9.44*2,24±0,412,98±0,5098,7433,32
O218.09 the 11.07 28.90±10.43*2,69±0,573,01±0,4959,7812,04
F73.72±1.075.01±1.181,84±0,362,97±0,63*34,6661,72
F83.20±0.754.48±1.112,27±0,493,12±0,7740,1537,53
T34.16±1.117.39±2.701,69±0,302,09±0,2177,4424,04
T42.89±0.614.72±1.04*1,35±0,211,71±0,1763,7126,92
T55.2±1.499.77±3.282,23±0,28*87,5533,92
T64.32±1.287.83±1.89*1,44±0,251,70±0,1281,0718,27
Note:1- average values of the spectral power of rhythm and their standard errors; * p<0.05 in comparison with the background values.

Example 2.

In the group of those same 10 people with an average age of 30.8±03.21 years (3 women and 7 men) were exposure to white light with a color temperature of 7000 K for 120 s, while there have been recorded EEG. Was determined spectral power of alpha and theta rhythms.

The rate of change of the average values of the spectral power of EEG rhythms when exposed to light, calculated with respect to their original level, are given in table 2. The table shows that the spectral power of alpha and theta rhythm on any of the leads has not changed by more than 25% neither downward nor upward. Indeed, all leads dynamics unreliable (p>0.05). Low level changes not exceeding 25%, does not allow the us to talk about the significant influence of light with 7000 K on the functional state of the human brain, and therefore, this light effect is physiologically neutral.

Table 2
Changes in spectral power of alpha and theta rhythms when exposed to light with a color temperature of 7000 K
Leadα-rhythmθ-rhythm% change
BackgroundLightBackgroundLightα-rhythmθ-rhythm
Fp1of 8.47±1,927,28±1,71the 4.29±0,774,47±0,62-14,03as 4.02
Fp26,92±1,916,13±1,223,50±0,623,69±0,44-11,455,33
F39,05±2,007,63±1,51 4.26 deaths±0,853,90±0,50-15,66-8,48
F47,70±1,697,07±1,233,38±0,433,93±0,44-8,1416,16
C39,20±2,208,55±1,97to 3.58±0,813,27±0,29-7,06-8,52
C4the 7.85±1,738,13±1,583,32±0,593,39±0,393,512,14
P3of 13.27±3,0214,56±4,993,86±0,963,00±0,349,75-22,31
P49,73±2,2410,48±2,023,17±0,623,17±034of 7.64-1,68
O122,07±6,94 22,33±8,733,26±0,762,65±0,451,16-18,81
O224,10±10,8422,80±remaining 9.083,30±0,77was 2.76±0,42-5,40-16,24
F74,99±0,864,36±0,872,64±0,532,92±0,49-12,7410,27
F84,63±1,093,93±0,862,67±0,622,46±0,33-15,23-7,91
T3to 5.21±1,114,42±1,141,92±0,371,66±0,20-15,06-13,82
T4of 3.46±0,751,08±0,801,79±0,261,50±0,1417,93-16,02
T5 7,32±1,747,19±2,01of 2.06±0,441,91±0,35-1,70-7,22
T6and 4.68±1,175,43±0,931,70±0,301,53±0,1715,93-10,12
Note: symbols are the same as in table 1.

Example 3.

In a group of 10 people with an average age 26.30±3.26 years (6 women and 4 men) were exposed to white light with a color temperature of 3800 K for 120 s, when this was carried out registration of the EEG. Calculated spectral power of alpha and theta rhythms.

Quantitative evaluation of changes in spectral power of EEG rhythms when exposed to light relative to their initial level shown in table 3. The table shows that in the range of theta rhythm, there was no increase or decrease in the spectral power of more than 25%. However, the light beam has an impact on alpha activity in the right occipital, srednespisochnoe and significanoe areas where the spectral power of the alpha rhythm decreased by more than 26%. In the derivations of T4 and T6 dynamics pokazatel the th has reached the level of significance (p< 0.05). A local decrease in the spectral power of the alpha rhythm indicates a significant influence of the light from the 3800 To the functional status of the right hemisphere of the human brain, and therefore, this light effect is physiologically active.

Table 3
Changes in spectral power of alpha and theta rhythms when exposed to light with a color temperature of 3800 K
Leadα-rhythmθ-rhythm% change
BackgroundLightBackgroundLightα-rhythmθ-rhythm
Fp112,65±4,5011,73±3,965,56±0,836,11±1,14-7,269,96
Fp212,22±4,0612,46±14,076,01±1,056,13±1,19 1,911,99

F314,52±4,3614,94±5,125,79±0,887,13±1,632,9422,97
F414,52±4,1214,53±lower than the 5.376,35±1,08to 6.88±1,490,058,39
C3of 21.50±6,0519,52±7,525,52±0,956,36±1,73-9,2115,05
C4http://21.00i5.63±18,13±6,875,97±0,966,13±1,45-13,682,64
P327,38±8,0325,48±-9,196,15±1,046,04±1,59-6,94-1,80
P425,73 the 6,91 22,24±7,225,76±0,956,24±1,54-13,58to 8.41
O139,44±br12.6232,53±12,075,35±0,844,91±1,00-17,51-8,26
O241,31±13,2430,35±9,406,15±1,156,10±1,70-26,53-0,74
F78,01±2,617,58±2,493,26±0,49of 3.60±0,65-5,4010,59
F88,21±3,028,05±2,943,85±0,824,01±10,81-1,88or 4.31
T39,75±12,149,01±2,643,15±0,503,22±0,57-7,582,04
T48,11±2,395,98±1,52*2,92±0,472,79±0,55-26,25-4,27
T513,89±of 13.0512,89±3,563,35±0,523,09±0,57-7,25-7,68
T615,61±4,8210,80±3,22*2,69±0,363,06±0,73-30,8013,67
Note: symbols are the same as in table 1.

Example 4.

In a group of 10 people with an average age 30.80±3.21 years (3 women and 7 men) were exposure to white light with a color temperature of 1700 K, duration 120 sec, it was recorded EEG. Next carried out the calculation of the spectral power of alpha and theta rhythms.

Quantitative changes in the mean values of the spectral power of EEG rhythms when exposed to light relative to their initial level in the state of quiet wakefulness presented in table 4. The table shows that the average spectral power of the alpha rhythm in Fp1, Fp2, F4, R, O1, O2, F7, F8, T3, T5 and the average spectral power of theta rhythm in Fp1, F3, P3, O1, F7, T4 increased by more than 25%. In parts of these areas improvements achieved reliable values (p<0.05). Thus, the exposure had an impact on cerebral electrical activity in the majority of EEG, not referring only P4 and T6. In General, the detected level of changes in the spectral power of alpha and theta rhythms in excess of background values by more than 25%, confirms the influence of light from 1700 K on the functional state of the human brain, and therefore, this light effect is physiologically active.

24,10±10,84
Table 4
Changes in spectral power of alpha and theta rhythms when exposed to light with a color temperature of 1700 K
Leadα-rhythmθ-rhythm% change
BackgroundLightBackgroundLight α-rhythmθ-rhythm
Fp16,22±1,72of 8.47±1,923,11±0,67the 4.29±0,7736,0537,95
Fp2the 5.51±1,626,92±1,913,00±0,653,50±0,6225,7116,99
F37,29±2,259,05±2,003,26±0,684.26 deaths±0,8524,1430,65
F46,14±1,797,70±1,693,31±0,633,38+0,4325,312,31
C37,74±2,279,20±2,20 to 3.58+0,8118,87of 23.11
C47,19±2,03the 7.85±1,732,96±0,593,32±0,599,2012,14
P39,41±3,41of 13.27±3,922,71±0,443,86±0,9641,0742,16
P47,87±2,309,73±2,242,83±0,523,17±0,6223,6011,75
O112,84±5,3522,07±6,94*2,24±0,413,26±0,7671,9245,76
O218,09±11,072,69±0,573,30±0,7733,2422,62
F73,72±1,074,99±0,861,84±0,362,64±0,53*34,3243,78
F83,20±0,754,63±1,092,27±0,492,67±0,6244,8017,57
T34,16±1,11to 5.21±1,111,69±0,301,92±0,3725,0914,00
T42,89±0,61of 3.46±0,751,35±0,211,79±0,26*19,9432,67
T5to 5.21±1,497,32±1,741.66±0,30of 2.06±0,4440,4223,90
T64,32±1,28and 4.68±1,171,44±0,251,70±0,30compared to 8.2618,31
Note: symbols are the same as in table 1.

Spectral analysis of EEG allowed to objectively evaluate changes in the basic rhythms of electrical activity in the brain when exposed to light with variable color temperature.

Based on our data, we can conclude that when exposed to open a person's eye white light with a color temperature of 1700-10000 K, the illuminance at eye level 80-300 LK, spectral analysis of the electroencephalogram showed that with the increase or decrease in the spectral power of alpha or theta rhythm by more than 25% of the background values of light exposure is assessed as physiologically active, and less than 25% of a physiologically neutral.

The proposed pic is b allows selection of the color temperature, affecting functional status of a person, when exposed to light radiation from the led source.

The method of assessing the impact on the functional state of the human brain light radiation, including the effects of white light from an led source, characterized in that the impact of exercise on the open eyes of a person with white light with a color temperature of 1700-10000 K, the illuminance at eye level 80-300 LK, record the electroencephalogram, conduct its spectral analysis and the increase or decrease in the spectral power of alpha or theta rhythm by more than 25% of the background values of light exposure is assessed as physiologically active, and less than 25% of a physiologically neutral.



 

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1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to anaesthesiology, and may be used in assessing an adequate general anaesthesia in the children aged from 4 to 14 years old. That is ensured by pre-anaesthetic and intra-anaesthetic intraoperative recording of long-latency auditory evoked potentials. That is followed by summing up initial latencies of first three pre-anaesthetic peaks (P1, N1, P2) to calculate sum A, subtracting the sum of the latencies of the first three intraoperative peaks (P1, N1, P2) to calculate sum B. The A to B relation is multiplied by 100. A percentage of the latencies of the intra-anaesthetic peaks P1, N1, P2 to the pre-anaesthetic values is considered as the adequate general anaesthesia. For the children of the first age group of 4-6 years old, the general anaesthesia is considered to be adequate, if the percentage is 140-253%; for the children of the second age group of 7-9 years old, the adequate general anaesthesia is shown by the percentage of 133-253%; for the children of the third age group of 10-12 years old, the adequate anaesthesia is shown by the percentage of 159-190%; and the percentage of 125-271% provides the adequate general anaesthesia for the children of the fourth age group of 13-14 years old.

EFFECT: method provides the adequate and easy assessment of the anaesthesia ensured by reducing a time of examination and simplicity of data interpretation in the form of one three-peak wave.

1 ex, 6 tbl

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to neurophysiological methods of examination. Registration of EEG is carried out, total power of modal fluctuation in alpha-rhythm range in one of leads is determined and FRα1 index is calculated as ration of said power to total power of all alpha range fluctuations in the same lead. Value of the sum of power of fluctuations, located ±0.5 Hz on the right and on the left from maximal power value, including maximal value, is determined, and FRα2 index is calculated as ratio of the obtained sum of power to total power of all fluctuations of alpha-range in the same lead. Intensity of brain affection is determined by comparison of obtained FRα1 and FRα2 values with standard values.

EFFECT: method makes it possible to determined quantitative ratio of alpha-rhythm, characteristic of separate nosologic units in psychiatry.

2 tbl, 1 dwg

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to pediatrics and can be used in neurology, medical psychology and psychiatry. Clinical examination of children is carried out by complaints, anamnestic information and data of physical examination. Assessed are: symptoms of vegetative manifestations at the moment of examination and peculiarities of sensomotor reactions: weight and length of body at birth, gestation age, response to stimulation in children of first year of life, sleep in children of first year of life, EEG in children of early age, parasomnia, enuresis, meteosensitivity, headaches, vessel lability, vestibulopathy, peculiarities of motor sphere, feeding behaviour, skin manifestations, course of infectious and somatic diseases, menstrual disorders in adolescent girls, brain ultrasound examination. Connection of said disorders with predominant dysfunction of right or left brain hemispheres is determined.

EFFECT: method makes it possible to increase reliability of diagnostics, which is achieved due to taking into account vegetative reactions and disorders in child of first year of life.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to oncologic neurosurgery, neurology, psychiatry and functional diagnostics. Electroencephalographic examination is carried out. Level of coherent connection between pole-frontal and anterior temporal regions of cerebral cortex on the right is calculated in beta-range. If said parameter is higher than 0.52, Korsakoff's syndrome is diagnosed.

EFFECT: method makes it possible to increase reliability of Korsakoff's syndrome diagnostics.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to drug-free methods for activation of the cerebral verbal functions. Cerebral signals are recorded. Their duration is measured. A related verbal stimulus is established for the derived wave duration and has an effect on the patient. That is followed by measuring the duration of the next current wave through a time interval not less than the maximum duration of the used verbal stimuli, and the patient is exposed to the verbal stimulus corresponding to the current wave. According to the other version of implementing the method, the duration of the current wave is measured, and the corresponding verbal and contextually harmonised visual stimuli are set for the above duration. The patient is exposed thereto. That is followed by measuring the duration of the regular current wave through a time interval not less than the maximum duration of the used verbal stimuli, and the patient is exposed to the verbal and contextually harmonised visual stimuli corresponding to the current wave.

EFFECT: invention enables acceleration the process of verbal development in children.

1 dwg, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to neurology, psychiatry and pediatrics. Factors of perinatal pathology risk are determined: extragenital diseases of mother during pregnancy and labour, complications of pregnancy and labour, low gestational age, estimation by Apgar scale and compromised obstetric history. Also determined is presence of neurological malfunctions during 1-st year of life: syndromes of motor malfunctions, increased neuroreflex excitability, vegetative-visceral disorders, depression, retardation of physhomotor and speech development; and in older age - cerebrosthenic syndrome and syndrome of child dysphasia in structure of symptom complex of MBD, epileptiform activity by EEG. Results of questionnaire for MBD detection are evaluated in points. Prognostic coefficients F1 and F2 are calculated in discriminating equations. If F1 is higher than F2, favorable courseof MBD is predicted, if F1 is less than F2, unfavorable course of MBD is predicted.

EFFECT: method makes it possible to increase reliability of MBD course prediction.

2 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine. Electroencephalogram (EEG) is registered in background mode, spectrograms are calculated by means of wavelet conversion with Morlet mother function. Frequency ranges of leading EEG rhythms are determined by finding values of coordinate minimums by frequency of envelope projections of wavelet spectrograms on "amplitude-frequency" coordinate plane. In frequency ranges times Ti of spectrogram peak appearance are determined by values of positions of maximums on envelope projection of wavelet spectrograms. Frequencies Fi and amplitudes Ai of peaks of spectrograms, which correspond to values of times of their appearance in each frequency range, are determined. For each discretisation window with ΔT, ΔF parameters, obtained by fragmentation of duration T and frequency range F of EEG registration, values ΣAi of sums of amplitudes of spectrogram peaks are calculated. If frequency increases, range of frequencies of peaks expands, interhemispheric asymmetry of electric activity is detected, early stage of Parkinson disease is diagnosed.

EFFECT: method makes it possible to increase reliability of determination of early stage of PD.

4 cl, 9 dwg, 1 ex

FIELD: medicine, neurology, psychopathology, neurosurgery, neurophysiology, experimental neurobiology.

SUBSTANCE: one should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another.

EFFECT: higher accuracy of diagnostics.

5 dwg, 1 ex, 1 tbl

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