Method of treating low-body-weight premature newborns
SUBSTANCE: invention refers to medicine, particularly to paediatrics and neonatology, and can be used for treating small premature infants at the hospital stage of developmental care. A therapeutic complex comprises administering a probiotic preparation into the newborns. The preparation is presented with a liquid probiotic containing E.faecium L3 109 CFU in 1 ml. If the enteral nutrition volume of the newborn is 5 ml or more, this preparation is orally administered in a dose of 0.5 ml 3 times a day for 14 days.
EFFECT: method is effective in children with a very low body weight, promotes normalising the intestinal microflora and reducing a rate of manifestations of infectious complications.
2 ex, 3 dwg, 3 tbl
The invention relates to medicine, in particular to the field of Pediatrics and neonatology, can be used to treat premature infants during the stationary phase of nursing.
There is a method of treatment of preterm infants with the use of probiotic preparations on the basis of lactobacilli and bifidobacteria (Tasheva NB Optimization in premature newborns with indirect hyperbilirubinemia and a violation of microbial colonization of the intestine: author. Diss. ... candles. the honey. Sciences. M; 2004. - 36 S.). However, despite the abundance of probiotic agents, treatment of premature children is not always successful, there are infectious complications such as intrauterine infection, vnutrietnicheskoe infection, necrotizing enterocolitis.
There is a method of treatment of functional disorders of the intestine and correction of the intestinal microflora in premature infants using a probiotic preparation Linex, which includes probiotic strains of B. infantis, L. acidophylus, E. faecium M74 (Gorobchenko Century, Kurashina I., Miller Y. Clinical and bacteriological efficacy of the probiotic "Linex" in premature infants. Doctor. 2008; No. 5. - P.70).
The disadvantage of this method is the use of freeze-dried and not liquid, forms of probiotic and to a much lesser dose (1,2×107SOME) put the m leaking capsules, that is not optimal, as well as the lack of data about the use of the drug Linex in the treatment of preterm infants during the stationary phase of nursing.
The purpose of the invention - expanding Arsenal of therapeutic tools for the treatment of preterm infants with very low birth weight conducive to the normalization of the intestinal microflora, and to improve treatment results in a reduction in the frequency of manifestation of infectious complications.
The purpose of the invention is achieved by including in the comprehensive treatment of the probiotic, and use liquid probiotic-based strain of E. faecium L3 containing 1 ml of 109KOE, and when the volume of enteral feeding newborn 5 ml and more the drug is administered orally in a dose of 0.5 ml 3 times a day for 14 days.
This probiotic form E. faecium L3 is a lactic acid ferment (no RU. 77.99.26.009.E.002272.02.11)used in the production of dairy products for therapeutic feeding in 1 ml contains 109SOME living microbial cells of Enterococcus.
The method is implemented as follows. Premature newborns with very low birth weight along with the standard treatment program include a comprehensive probiotic treatment, and use of liquid probiotic-based strain of E. faecium L3 containing 1 ml of 109SOME, and when the volume of enteral p is Tania newborn 5 ml and more the drug is administered orally in a dose of 0.5 ml 3 times a day for 14 days.
Dignity liquid probiotic forms of E. faecium L3 is the preservation of strains of probiotic bacteria active in a viable state.
Below is an example of practical realization of the proposed method of treatment.
Premature girl Efimova C. was treated at children's hospital No.1 in St. Petersburg in 2012 (history No. 777) with a clinical diagnosis of Prematurity, gestation 31 week. Outdoor aortic duct, medical closure. Early anemia of prematurity mild. Perinatal CNS hypoxic Genesis.
She was born at term pregnancy 31 week with weight 1340 was on the standard scheme for the nursing of premature infants receiving total parenteral nutrition with subsequent transition on partial parenteral nutrition and enteral nutrition (getting through the probe of breast milk and formula, Brenan) on day 6 of life. At the age of 7 days of life, given the good tolerance of the used mode of enteral nutrition in the child's diet was introduced liquid probiotic form on the basis of E. faecium L3 at a dose of 0.5 ml 3 times a day (using bolus in enteral probe during feedings). Therapy was carried out within 14 days. The total duration of mixed feeding through a tube (breast milk and supplementary feeding with a mixture of Brenan) amounted to 30 days. Next Devo the spacecraft was transferred to breast milk in the mode of physiological needs. Antibiotic therapy was given for 26 days with changing groups of drugs (at the time of standing Central venous catheter). In the observation period for a child there were increasing numbers of anemia of prematurity (hemoglobin with 172 g/l decreased to 106 g/l), and do not require replacement therapy; leukocytosis was not significantly increased (8,1*109/l to 11.2*109/l), neutrophil shift in leukocyte formula was not observed. Eosinophilia for discharge is not marked (the relative number of eosinophils in the blood was 4%). In repeated coprogrammed inflammatory changes were found. In the biochemical analysis blood was not recorded increase of ALT, AST, CRP.
According to the bacteriological examination of faeces for the admission of the child to inpatient treatment was marked by the growth of opportunistic flora: K. pneumoniae in high titer of 106CFU/g
The follow-up bacteriological examination of faeces (14 days after completion of therapy liquid probiotic form on the basis of E. faecium L3) K. pneumoniae was not detected. Evaluation of the indigenous intestinal microflora according to the study of faeces by PCR in real time after complex therapy with the use of the probiotic on the basis of E. faecium L3 in the number of lactobacilli and bifidobacteria corresponded to a sufficient level of 108To the E/g
The girl was discharged home with body weight 2010 at the age of 1 month 15 days. Side effects of combined therapy with the use of the probiotic on the basis of E. faecium L3 was not observed. The number of days of hospitalization was 45.
Clinical example 2 using the traditional method of treatment of extremely premature infants at the stage of nursing in the hospital shows less favorable results.
Premature girl Frolov D. was treated at children's hospital No.1 in St. Petersburg in 2011 (case history No. 11882) with clinical diagnosis of Prematurity, gestation 29 weeks. The syndrome of respiratory disorders. Early anemia of prematurity grade. Perinatal CNS hypoxic Genesis. Acute respiratory disease (rhinitis).
Born with gestational age 29 weeks with a weight of 1500 was on the standard scheme for the nursing of premature infants receiving total parenteral nutrition with subsequent transition on partial parenteral nutrition and enteral nutrition (getting through the probe nutrient mixture Prenan) on day 12. Received antibiotic therapy within 30 days from the change of groups of drugs (at the time of standing Central venous catheter). During the observation period, the child was noted to increase the overall leukocytosis (14.8*109/l to 19.9*109/l) without neutrophilic shift in leukocytospermia. There are also significant fall in hemoglobin level (with 158 g/l to 90 g/l); increased eosinophilia (from 4% to 20%), monocytosis (15%). In coprogrammed noted the presence of fungi of the genus Candida. According to biochemical analysis blood was not recorded increase of ALT, AST, CRP.
According to the bacteriological examination of faeces for the admission of the child to inpatient treatment there is a high titer of K. pneumoniae (106CFU/g). In future studies marked increase in titer of K. pneumoniae to 107CFU/g in Addition, selected in the re-examination of the faeces of a child opportunistic organism K. pneumoniae were characterized by a higher resistance to antimicrobial agents and bacteriophages. Evaluation of indigenous microflora of the intestine according to the study of faeces method of Poland in the real time dynamics monitoring showed a reduction in the level of bifidobacteria (108CFU/g to 107CFU/g).
The baby is discharged from hospital was delayed (despite the achievement level of body weight 2000) by reason of the accession of infectious process in the form of acute rhinitis.
The girl was discharged from hospital at the age of 1 month 26 days with body weight 2540, the Number of days of hospitalization was 57.
Experience in the use of probiotics in premature infants includes Bifidumbacterin, Bifidumbacterin Forte, Probit is, Acipol, Azilect, Lactobacterin, Linex, Sifilis (www.disbak.ru). As of probiotics in preterm infants used probiotic strains B. bifidus, B. infantis, B. brevis, B. lactis, Str. thermophilus, L. acidophilus, L. casei, Lactobacillus GG, S. boulardii (Deshpande g, Rao s, Patole S. Probiotics for prevention of necrotising enterocolitis in preterm neonates with very low birth weight: a systematic review of randomised controlled trials. Lancet 2007; 369:1614-1620).
In the previous analogues in premature infants has not been used probiotic strain E.faecium L3.
To prove the possibility of industrial applicability of the proposed method was investigated treatment outcomes of premature infants at the stage of nursing in the hospital.
In the specialized neonatal care unit, children's multidisciplinary pediatric hospital in the process of nursing watched 55 preterm with very low birth weight (ONMT): 24 boys and 31 girls, born on 29,0±0,3 (M±M) weeks of gestation. Patients were enrolled from maternity wards and the intensive care unit of the hospital; the child's age at the time of admission was 3.3±0,5 DN., body weight - 1204,0±26,6 g; body length is 37.0±0.4 cm In the study did not include patients with gross malformations, severe perinatal lesions of the Central nervous system. Standard program in premature newborns with ANMT included: adequate primary resuscitation, respiratory support (primaveraestate), thermal regime, antibiotic therapy, early provision of nutrients, including total parenteral nutrition, then partial parenteral nutrition supplemented enteral nutrition. The transfer of children on enteral nutrition provided consistent use of nutrient formulas Alfare, Prenen, NAN Hypoallergenic (and/or breast milk).
The observed patients were randomized into two groups. Group 1 (n=26, the comparison group) received standard therapy. Group 2 (n=29, the main group) in the absence of signs of intolerance to enteral nutrition advanced through enteral tube had received liquid probiotic form on the basis of E. faecium L3 containing 1 ml of 109KOE, 0.5 ml 3 times a day for 14 days.
Efficiency programs nursing children with EMT was assessed by frequency of occurrence in children situations "power supply", the frequency of diagnosis of infectious complications, the nature of changes in hematological indices, duration of parenteral nutrition, duration of antibiotic therapy, length of hospital stay, the dynamics of the composition of the intestinal microbiota. To infectious complications attributed diagnosed viral intrauterine infection (IUI) in 9 children, vnutrietnicheskoe infection (VAI) 10 infants, necrotizing enterocolitis (ne is) - 2. The implementation of the programme of study was approved by the Committee on ethics.
Qualitative and quantitative composition of the intestinal microbiota in preterm children studied three times with an interval of 14 days according to the study of faeces methods real-time PCR and advanced bacteriological analysis with determination of the number of anaerobic and aerobic microorganisms (periods of research 1-2-3). Fence faeces for study 1 was made the next day after receipt of children. In group 1 study 2 was conducted after completion of therapy probiotic form on the basis of E. faecium L3. By the time of first sampling no child received probiotic preparations.
Study of clinical and paraclinical parameters were adapted for mathematical treatment and analyzed using simple methods (parametric and non-parametric statistics and multivariate statistical analysis.
Table 1 shows the frequency characteristics of the unfavourable flow of premature infants with very low birth weight in the comparison group (group 1) and experimental group (group 2).
The study of the characteristics common to the adverse currents of nursing observed in preterm children with EMT, revealed significantly higher frequency shown is th infectious complications in patients of group 1.
It should be noted that the NEC was diagnosed only in group 1 2 (7,7%) children. In this same group also noted the high frequency of occurrence of situations of "power supply"; leukocytosis, monocytosis (p<0.05) and eosinophilia in the blood. The incidence of bronchopulmonary dysplasia, neonatal jaundice in groups 1 and 2 did not differ significantly.
Comparison of used programs for the treatment of premature infants of group 1 and group 2 for the duration of inpatient treatment (52,5±2,8 days.; 54,2±4,1 days.; p>0.05), and the duration of parenteral nutrition (18,0±1,9 days.; 19,8±2,2 days.; p>0.05), and the duration of the period before the transition to full enteral nutrition (18,8±1,9 days.; 20,3±2,2 days.; p>0,05) showed no significant differences.
Figure 1 presents the evaluation of the dynamics of the number of bacteria (CFU/g) during periods 1, 2, 3 by the method of variance analysis according to the study of faeces by PCR in real time in premature infants with ANMT the comparison group and the experimental group.
Figure 2 presents the assessment of the dynamics in the number of lactobacilli (CFU/g) during periods 1, 2, 3 by the method of variance analysis according to the study of faeces by PCR in real time in premature infants with ANMT the comparison group and the experimental group.
Figure 3 presents the assessment of the dynamics of the number of Klebsiella (CFU/g) during periods 1, 2, 3 method of analysis of variance bacteriological data and the sequence of faeces in premature infants with ANMT the comparison group and the experimental group.
By variance analysis was to study the dynamics of the composition of the indigenous and conditionally pathogenic microflora in premature infants with EMT and installed the following. Unlike premature babies group 2, the number of bifidobacteria (Fig.1) and lactobacilli (Fig.2) between periods 1 and 2 in children of group 1 were significantly more. The number of Klebsiella between periods of studies 1 and 2 in group 1 was increased (Fig.3).
Table 2 presents the assessment of the dynamics of the composition of the intestinal microflora in paired samples using Wilcoxon'a premature infants of group 1.
Table 3 presents the assessment of the dynamics of the composition of the intestinal microflora in paired samples using Wilcoxon'a premature infants group 2.
Comparison of the dynamics of the composition of the indigenous and UPM intestines of premature infants with ANMT under the influence of various regimens method Wilcoxon'a (not limited by the normal distribution of the data for paired samples revealed that children in group 1 significant decrease (p<0,05) in the amount of bifidobacteria (periods 1-3) and the increase in the number of Klebsiella (p<0.05) in periods 1-2. In children of group 2 showed a significant increase (p<0,05) number of Klebsiella in periods 1-3.
Thus, during the nursing of premature infants in the hospital in both groups of patients on the background of the oppression of the indigenous flora was noted n is increased Klebsiella, which is the brightest representatives of nosocomial flora.
The use of probiotic forms of E. faecium L3 in premature infants with OMT group 2 inhibited the growth of pathogenic microorganisms on the background of antibiotic treatment that was one of the defining factors contributing to the decrease in the frequency of infectious complications in this group.
|The studied parameters||Group 1||Group 2||Pearson|
|Central venous access more than 10 days.||3 (11,5%)||23 (88.5 percent)||2 (6,9%)||27 (93,0%)||0,02||>0,05|
|Antibiotic therapy for more than 10 days.||2 (8,7%)||24 (92.3 per cent)||3 (10,3%)||26 (89,7%)||0,09||>0,05|
|The situation of power supply"||16 (61,5%)||10 (38,5%)||23 (79.3 percent)||6 (20,7%)||1,88||>0,05|
|VUI||20 (76,9%)||6 (23.1 per cent)||26 (89,7%)||3 (10,3%)||1,62||>0,05|
|VAI||19 (73.1 per cent)||7 (26.9 per cent)||26 (89,7%)||3 (10,3%)||2,53||>0,05|
|Infectious complications||12 (46,2%)||14 (53.8 per cent)||23 (79.3 percent)||6 (20,7%)||6,51||<0,05|
|Positive seeding from the blood||25 (96,2%)||1 (3,8%)||27 (93.1%)are||2 (6,9%)||0,24||>0,05|
|Leukocytosis||14 (53.8 per cent)||12 (46,2%)||17 (58.6 per cent)||12 (41.4 per cent)||0,06||>0,05|
|Anemia||4 (15,4%)||22 (84,6%)||4 (13,8%)||25 (86.2 per cent)||0,26||>0,05|
|Monocytosis||0||26 (100%)||5 (17,2%)||24 (82,8%)||4,01||<0,05|
|Eosinophilia||12 (46,2%)||14 (53.8 per cent)||18 (62.1 per cent)||11 (37.9 per cent)||1,15||>0,05|
|Compare the characteristics and periods of studies of the intestinal microflora||Valid N||T||Z||p-level|
|Bifidobacteria (periods 1-2)||22||level 113.0||0,08||>0,05|
|Bifidobacteria (periods 1-3)||20||51,5||1,99||<0,05|
|Lactobacilli (periods 1-2)||18||of 60.5||0,39||>0,05|
|Lactobacilli (periods 1-3)||18||75,5||0,05||>0,05|
|Klebsiella (periods 1-2)||7||0,0||2,37||<0,05|
|Klebsiella (periods 1-3)||9||6,5||1,27||>0,05|
|Compare the characteristics and periods of studies of the intestinal microflora||Valid N||T||Z||p-level||Bifidobacteria (periods 1-2)||20||94,5||0,39||>0,05|
|Bifidobacteria (periods 1-3)||20||71,0||0,63||>0,05|
|Lactobacilli (periods 1-2)||20||94,5||0,39||>0,05|
|Lactobacilli (periods 1-3)||18||72,0||0,21||>0,05|
|Klebsiella (periods 1-2)||11||9,0||1,60||>0,05|
|Klebsiella (periods 1-3)||10||1,0||1,99||<0,05|
A method of treating premature babies with low birth weight by including in the comprehensive treatment of the probiotic, characterized in that use liquid probiotic-based strain of E. faecium L3 containing 1 ml of 109SOME, and when the amount of enteral the th power of the newborn 5 ml and more the drug is administered orally in a dose of 0.5 ml 3 times a day for 14 days.
SUBSTANCE: group of inventions relates to biotechnology and medicine. Disclosed is a polysaccharide which is isolated from the Bifidobacterium infantis NCIMB 41003 strain and has the structure [-β(1,3)-D-GalpNAc-β(1,4)-D-Glcp-]n, where said disaccharide unit repeats n times, which yields a polysaccharide with molecular weight greater than 100000 Da. The polysaccharide exhibits immunomodulating activity and is used in preparing medicinal agents for treating or preventing undesirable inflammatory activity, undesirable gastrointestinal inflammatory activity, rheumatoid arthritis and autoimmune disorders.
EFFECT: pharmaceutical composition for treating and preventing inflammatory disorders and a food product containing the isolated polysaccharide are disclosed.
9 cl, 6 dwg, 3 ex
SUBSTANCE: invention relates to a compound CL168 of general structural formula I where R is oxygen. The invention also relates to a method of producing a compound of formula I and use of the compound of formula I to produce a medicinal agent for preventing or treating tumorous and immunological diseases.
EFFECT: compound of formula I for producing a medicinal agent for preventing or treating tumorous and immunological diseases.
4 cl, 11 tbl, 19 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, namely to an immunomodulator. An immunomodulator for the immunocorrection accompanying the integrated treatment of chronic non-specific pulmonary diseases, chronic obstructive pulmonary disease, bronchial obstruction syndrome, chronic bronchial pneumonia, pulmonary fibrosis, tracheobronchitis, chronic laryngitis, pulmonary, tracheal and pharyngeal cancer; the immunomodulator is prepared by mixing a water infusion of rose bay leaves and a water infusion of yellow melilot taken in equal proportions, with a cattle lung and larynx powder, settling the prepared mixture, keeping on a boiling water bath, cooling; further, the mixture is filtered; the prepared solution is added with cattle blood serum containing leukaemia oncovirus antibodies, hemlock infusion, ascorbic and sorbic acids until all the ingredients fully dissolved; the prepared solution is placed in the water bath, cooled, filtered, sterilised under certain conditions.
EFFECT: above preparation provides higher effectiveness and reduces the length of treating the above diseases, and ensures the higher immunobiological properties of the human body.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, namely to an extract of one or more bacterial strains Lactobacillus. The extract of one or more bacterial strains Lactobacillus representing a soluble extract, wherein the extract contains chemically modified bacterial molecules prepared by the action of an alkaline medium on one or more bacterial strains Lactobacillus; the extract is effective in treating diseases associated with the anti-inflammatory cytokine production imbalance. A method for preparing the extract of one or more bacterial strains Lactobacillus. A pharmaceutical composition effective for reducing at least one symptom associated with at least one condition specified in a respiratory disorder, an allergic condition, an urinary disorder and a gastric disorder, containing the extract. A nutritional composition. A pharmacological composition effective in treating the diseases associated with the anti-inflammatory cytokine production imbalance, containing the extract. A method of relieving the above symptoms. The extract prepared by the above method.
EFFECT: extract is effective in treating the diseases associated with the anti-inflammatory cytokine production imbalance.
21 cl, 7 dwg, 23 tbl, 5 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to medicine, namely to using at least one immunomodulatory compound of general formula (1) or a pharmaceutically acceptable, solvate or isomer thereof for preparing a pharmaceutical composition for treating a disease or disorder specified in asthma, atopic dermatitis, allergic rhinitis, inflammatory intestinal disease, diabetes or rheumatoid arthritis in homoiothermal animal, including a human. What is also presented is using (5S,11R)-1-amino-5-[(R)-3-dodecanoyloxytetradecanoylamino]-6-oxo-7-aza-11-[(R)-3-hydroxytetradecanoylamino]dodecan-12-ol-12-dihydrophosphate (OM-294-BA-MP (S,R)) or a pharmaceutically acceptable salt, solvate or isomer thereof for preparing the pharmaceutical composition.
EFFECT: group of inventions provides treating the above diseases by modulating the TH1/TH2 cytokine balance by reducing TH2-cytokine release and enhancing TH2-cytokine production.
11 cl, 16 dwg, 14 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biotechnology, more specifically to preparing interferonogenic antiviral agents of yeast RNA, and may be used in medicine. The IFN-γ inducer is presented by a soapy amphiphilic complex of high-polymer Saccharorayces cerevisiae RNA and oleic acid penetrating easily through biological membranes in the following proportions: high-polymer RNA - 80-90%, oleic acid - 10-20%.
EFFECT: invention enables inducing interferon γ (IFN-γ) production effectively with using available and low-cost ingredients.
2 tbl, 5 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, namely a method for preparing an agent possessing immunomodulatory activity. The method for preparing an agent possessing immunomodulatory activity characterized by the fact that herbal composition containing common motherwort herb, knotgrass herb, pot marigold blossom, licorice rhizome and root, Alexandrian laurel rhizome and root, rosehip, schizandra fruit, linseeds, sequentially twice extracted in 60-70% ethanol, twice in 40-50% ethanol, and once in purified water under specific conditions; then the aqueous-alcoholic extracts are concentrated in vacuum; the aqueous still residues are combined with the aqueous extract, then filtered, boiled out, purified by separation, boiled out additionally, dried in a vacuum dryer and further milled.
EFFECT: method enables preparing the agent possessing manifested immunomodulatory activity with the high content of active substances.
13 tbl, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pyridine derivatives of formula (I) wherein A, R1, R2, R3, R4, R5, R6 and R7 are presented in the description, preparing and using them as pharmaceutically active compounds possessing SP1/EDG1 receptor agonist activity.
EFFECT: using the declared compounds or pharmaceutically acceptable salts thereof for preparing a pharmaceutical composition for preventing or treating the diseases or disorders associated with the activated immune system.
13 cl, 76 ex, 2 tbl
SUBSTANCE: hemorrhagic pancreonecrosis is preliminarily modelled on animals. After that, tamerit in dose 2 mg/kg is introduced intramuscularly. After that, histological analysis of pancreas tissue after the first, third and seventh day is performed and its results are used to make conclusion about sufficiency and efficiency of performed treatment.
EFFECT: method ensures correction of the course of acute phase of systemic inflammatory reaction syndrome, which leads to stimulation of migration of immunocompetent cells into necrosis foci, acceleration of formation of granulation tissue with proliferation of cells of fibroblast line without phenomena of purulent inflammation, stimulation of proliferation of pancreas duct structures.
SUBSTANCE: invention relates to field of medicine and is intended for treatment of vaginal infections. Method includes complex therapy with application of immunocorrector. As immunocorrector solution of medicine Betaleukin, introduced intravaginally during 40-90 minutes daily at least during 5 days, is applied.
EFFECT: method is highly efficient in complex therapy of vaginal infections.
SUBSTANCE: invention provides crystalline solid form of (S)-4-((2S,3S)-7-carbamoyl-1,1-diethyl-3-methoxy-1,2,3,4-tetrahydronaphthalin-2-ylamino)-2-cyclohexylmethyl-butyric acid or crystalline hydrochloride of (S)-4-((2S,3S)-7-carbamoyl-1,1-diethyl-3-methoxy-1,2,3,4-tetrahydronaphthalin-2-ylamino)-2-cyclohexylmethyl-butyric acid. Invention relates to pharmaceutical composition, possessing antagonistic activity with respect to mu-opioid receptor, which contains therapeutically effective quality of crystalline solid form.
EFFECT: invention provides methods of applying claimed crystalline solid forms in treatment of diseases associated with activity of mu-opioid receptors and methods of obtaining claimed crystalline solid forms.
27 cl, 9 dwg, 17 ex
SUBSTANCE: invention refers to veterinary science. A preparation for the prevention of diarrhoeas in newborn calves containing acid hydrolysate of animal blood, lactic, benzoic, succinic acids, additionally contains acetic acid, in the following ratio, wt %: acetic acid 0.4-0.5, lactic acid 0.05-0.06, benzoic acid 0.04-0.05, succinic acid 0.02-0.03, acid hydrolysate of animal blood - the rest.
EFFECT: invention provides a lower probability of diarrhoeas in the newborn calves and reducing a mortality rate.
3 tbl, 6 ex
SUBSTANCE: invention refers to medicine and may be used for relieving abdominal murmur. That is ensured by the oral administration of the bacteria Bifidobacterium animalis in dose 1×109 CFU a day. The bacteria are administered every day, for at least 15 days.
EFFECT: method provides relieving abdominal murmur in a healthy individual that is ensured by the developed dose schedule and specific rate of administration of the above prebiotic.
10 cl, 1 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutics, namely to a composition for preventing and/or treating respiratory pathologies and/or infections and for improving intestinal functions. Using a symbiotic composition for preparing a drug preparation for preventing and/or treating the respiratory pathologies and/or infections. The symbiotic composition containing an active ingredient presented by a) a mixture containing the following bacterial strains: Lactobacillus plantarum LMG P-21020; Lactobacillus plantarum LMG P-21021; Lactobacillus rhamnosus DSM 16605; Lactobacillus rhamnosus DSM 19739; Bifidobacterium lactis LMG P-21384 and b) a prebiotic ingredient containing at least one scFOS (short-chain fructooligosaccharide) or GOS (galactooligosaccharide).
EFFECT: using the declared method enables more effectively preventing and/or treating the respiratory pathologies with simultaneously improving and/or controlling the intestinal functions.
11 cl, 2 tbl, 2 ex
SUBSTANCE: invention refers to medicine, particularly gastroenterology, and may be applied in treating secondary lactase deficiency. For this purpose, with underlying diet and drug-induced therapy, bifiform 1 tablet 2-3 times a day and No-spa 1-2 tablets 3 times a day are additionally administered. The therapeutic course makes 14 days.
EFFECT: method enables higher clinical effectiveness in secondary lactase deficiency.
SUBSTANCE: invention provides using a prepared compound of a ghrelin splicing version for preparing an effective drug preparation activating body weight and food intake gain and/or stimulating growth hormone release, as well as for treating or preventing cachexia, lipodystrophy and muscle atrophy.
EFFECT: higher clinical effectiveness.
6 cl, 6 dwg, 13 ex
SUBSTANCE: what is presented is the use of the strain Lactobacillus johnsonii in preparing a probiotic composition for prevention of postoperative abdominal and pelvic infections caused by pelvic liquid accumulation, anastomosis leakage, or caused by bacterial translocation.
EFFECT: colonic L Johnsonii Lai colonisation in the patients underwent colectomy for colorectal adenocarcinoma.
11 cl, 1 dwg, 1 tbl, 2 ex
SUBSTANCE: there are offered: application of a water-soluble indigestible saccharide for preparing a composition wherein the composition is introduced in a pregnant woman for improving the developing intestinal microflora of an expected newborn; reinforcing the immune system and/or preventing the diseases associated with the immune system of the expected newborn; or reinforcing the immune system of the foetus (versions). What is also presented is the application of the water-soluble indigestible saccharide wherein the saccharide is a galactose-containing saccharide containing at least 50% of galactose units of the total amount of monosaccharide units found in the saccharide for preparing the composition for reinforcing the immune system of the pregnant woman; improving the vaginal flora of the pregnant woman wherein the composition is introduced in the pregnant woman.
EFFECT: increased percentage of bifidus bacteria and lactic acid bacilli in the intestinal flora of pregnant women, intestinal colonisation of the newborn by lactic acid bacilli and reinforcement of the immune system.
11 cl, 2 ex
SUBSTANCE: invention relates to veterinary science. A method includes the administration of a medicinal agent. The medicinal agent is presented by 0.25% alcohol solution of Chlorophyllipt 3 ml in normal saline 57 ml which is introduced intravenously twice a day for 2-3 days in dose of 60 ml per a calve if observing simple dyspepsia and four times if observing toxic dyspepsia. It is combined with the oral introduction of 1% alcohol solution of Chlorophyllipt 10 ml at 900 ml in normal saline prescribed twice a day in dose 1000 ml in both forms of dyspepsia.
EFFECT: method provides higher therapeutic effectiveness, reduces length of treatment, has no side action on calve bodies, eliminates recurrences.
SUBSTANCE: strain Bifidobacterium longum B-NH is recovered from a healthy infant, actively propagates in a nutrient medium with accumulation of an production biomass in a short 12-18-hour period of cultivation time of the high bifidus bacteria concentration, is able to sour milk. The Bifidobacterium longum B-NH strain exhibits acid-forming activity, pathogen and opportunistic pathogen antagonist activity. It makes it possible to use the strain Bifidobacterium longum B-NH as an ingredient of bifidus products - bacterial preparations, biologically active food additives, fermented and non-fermented foodstuff, toiletry and care preparations enabling normalised human body microbiocenosis, including gastrointestinal and urogenital tracts, skin and mucous membranes, and extends the range of products for correction of human microflora. The strain Bifidobacterium longum B-NH is deposited in Russian National Collection of Industrial Microorganisms, No. VKPM Ac-1876.
EFFECT: invention provides higher activity of bifidus products.
2 tbl, 5 ex
SUBSTANCE: invention refers to medical devices, particularly to drug delivery devices. The device comprises an expandable element having an external surface contacting surrounding tissue. A liquid formulation of a therapeutically active substance is connected to the external surface. The liquid formulation contains rapamycin in a pharmacologically effective dosage, ethanol in a trough concentration of approximately 1.57 mass percent, vitamin E TPGS in an amount of approximately 6.55 mass percent and water in an amount of approximately 90.51 mass percent. The liquid formulation contains a finishing solution of rapamycin in a span of concentrations from approximately 4 mg/ml to approximately 15 mg/ml. The expandable element can represent, e.g. a stent.
EFFECT: device provides the local and regional delivery of the therapeutically active substances for inhibiting body reaction to introducing the device, thereby preventing thrombosis, treating restenosis, and atherosclerotic plaques in the patients suffering diabetes mellitus.
6 cl, 111 dwg, 23 tbl