Method for objective estimation of responses to orthopaedic alignment

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely dentistry. An encephalogram (EEG) is recorded in patients with the disturbed cerebral hemodynamics. The EEG is repeated with an occlusal load using 10-20 g of comb honey for 3-4 minutes. If a post-therapeutic alpha rhythm recovers or prevails on the EEG, the conducted orthopaedic alignment is considered to be effective.

EFFECT: method provides more reliable estimation of the orthopaedic alignment of dental patients suffering a cerebrovascular pathology that is ensured by using the occlusal load.

4 dwg, 1 ex

 

The present invention relates to medicine, namely to the dentist, and can be used to evaluate orthopedic treatment dentures patients with neurological profile.

The need for prosthetic defects of dentition removable dentures in patients after 50 years is 56%in patients of younger age (from 40 to 50 years) removable prostheses are also used quite often from 15 to 20%. This is due to early loss of teeth, destroyed by caries or trauma, or periodontal disease, etc. when for the preservation of healthy teeth, edge defect, I prefer removable prosthesis designed to achieve the maximum level of aesthetics. Prosthetics dentures need the vast majority of the elderly who have expressed vascular diseases of the nervous system. Chronic cerebral circulation insufficiency leads to very serious consequences - stroke and vascular dementia. Patients cerebrovascular pathology people aged 40 to 80 years. In dental research mainly this age is characterized by patients with partial loss of teeth. Indications for orthopedic treatment partial dentures such patients are high: on the defects of dentition bol is trolled length, bilateral and unilateral included defects of dentition intact when the abutment teeth, the end of the defects of dentition, periodontal disease, etc. So if orthodontic treatment is necessary to consider and assess the General condition of patients. A very important adaptation of patients with cerebrovascular pathology in orthopedic treatment of partial removable dentures.

There is a method of assessing the quality of life in patients with defects of dentition (RF patent No. 2406440, IPC AV 5/16, publ. in BI from 20.122.2010 year). The known method is that before and after orthopedic treatment surveys of patients, including the assessment of the clinical condition of dentition, symptoms, assessment of the impact of the defect of dentition (DER) on the physical condition of the patient (physical functioning), assessment of the impact of DER on the psycho-emotional state of the patient, assess the impact of DER on the social functioning of the patient, assessment of the impact on the patient's life of the orthopedic treatment. Each block consists of 5 questions, each answer is evaluated on a 5-point scale. The first question concerns the assessment of the state of dentition, the second violation of the functions of mastication, the third - psycho-emotional state, the fourth - social functioning and the fifth question is the effect of conducted cured the eat on the patient's life. The resulting points are added up. A survey carried out after 1, 2 and 3 months after treatment. The method allows on the basis of the proposed criteria to conduct an accurate assessment of the quality of life in patients with defects of dental rows.

However, the designed questionnaire does not take into account the effect of treatment on the General condition of patients, including patients with cerebrovascular disease.

A prototype of the invention is selected known method of objective evaluation of the results of orthodontic treatment, including research using hardware methods changes before and after treatment (RF patent No. 2444292, IPC AV 6/14, publ. from 10.03.2012). The known method is as follows. Receive and analyze lateral and pasnau teleroentgenograms head, jaws, pasnau and profile pictures of the patient's face. Evaluate disorders of the chewing-the vocal apparatus, the close positioning of the teeth, their retention and to edentulous patient treatment and after treatment. Identified characteristics of dentofacial anomalies assigns the first, second or third degree of the: before and after treatment. The data are summarized in table. In the vertical columns of the table presents the direction (sagittal, vertical and transverse), and horizontal-the prize is Aki, SCA (morphological, occlusive, aesthetic and functional). In the second part of the table in the vertical columns represent characteristics such as the close positioning of the teeth, their retention and edentulous, horizontal - their potential severity. On the comparison of the severity of the symptoms of SCA before and after treatment make a conclusion about the effectiveness of the treatment. The disadvantage of this method is the lack of accurate and unbiased assessment of the results of orthodontic treatment in patients with cerebral lesions of the brain.

The task of the invention is to improve the accuracy and objectivity of the evaluation of the effectiveness of orthopedic treatment of patients with concomitant diseases of the neurological profile.

The present invention relates to medicine, namely to the dentist, and can be used to evaluate orthopedic treatment dentures patients with neurological profile.

The need for prosthetic defects of dentition removable dentures in patients after 50 years is 56%in patients of younger age (from 40 to 50 years) removable prostheses are also used quite often from 15 to 20%. This is due to early loss of teeth, destroyed by caries or trauma, or periodontal disease, etc. when aiming with the retention of healthy teeth, edge defect, I prefer removable prosthesis designed to achieve the maximum level of aesthetics. Prosthetics dentures need the vast majority of the elderly who have expressed vascular diseases of the nervous system. Chronic cerebral circulation insufficiency leads to very serious consequences - stroke and vascular dementia. Patients cerebrovascular pathology people aged 40 to 80 years. In dental research mainly this age is characterized by patients with partial loss of teeth. Indications for orthopedic treatment partial dentures such patients are high: on the defects of dental rows wide range of bilateral and unilateral included defects of dentition intact when the abutment teeth, the end of the defects of dentition, periodontal disease, etc. So if orthodontic treatment is necessary to consider and assess the General condition of patients. A very important adaptation of patients with cerebrovascular pathology in orthopedic treatment of partial removable dentures.

There is a method of assessing the quality of life in patients with defects of dentition (RF patent No. 2406440, IPC AV 5/16, publ. in BI from 20.122.2010 year). The known method is that the before and after of tapeedikeskus the treatment of a survey of patients, including the assessment of the clinical condition of dentition, symptoms, assessment of the impact of the defect of dentition (DER) on the physical condition of the patient (physical functioning), assessment of the impact of DER on the psycho-emotional state of the patient, assess the impact of DER on the social functioning of the patient, assessment of the impact on the patient's life of the orthopedic treatment. Each block consists of 5 questions, each answer is evaluated on a 5-point scale. The first question concerns the assessment of the state of dentition, the second violation of the functions of mastication, the third - psycho-emotional state, the fourth - social functioning and the fifth question is the effect of treatment on the patient's life. The resulting points are added up. A survey carried out after 1, 2 and 3 months after treatment. The method allows on the basis of the proposed criteria to conduct an accurate assessment of the quality of life in patients with defects of dental rows.

However, the designed questionnaire does not take into account the effect of treatment on the General condition of patients, including patients with cerebrovascular disease.

A prototype of the invention is selected known method of objective evaluation of the results of orthodontic treatment, including research using hardware methods for the study of changes before and after treatment (RF patent No. 2444292, IPC A61 In 6/14, publ. from 10.03.2012). The known method is as follows. Receive and analyze lateral and pasnau teleroentgenograms head, jaws, pasnau and profile pictures of the patient's face. Evaluate disorders of the chewing-the vocal apparatus, the close positioning of the teeth, their retention and to edentulous patient treatment and after treatment. Identified characteristics of dentofacial anomalies assigns the first, second or third degree: before and after treatment. The data are summarized in table. In the vertical columns of the table presents the direction (sagittal, vertical and transverse), and horizontal-signs of SCA (morphological, occlusive, aesthetic and functional). In the second part of the table in the vertical columns represent characteristics such as the close positioning of the teeth, their retention and edentulous, horizontal - their potential severity. On the comparison of the severity of the symptoms of SCA before and after treatment make a conclusion about the effectiveness of the treatment. The disadvantage of this method is the lack of accurate and unbiased assessment of the results of orthodontic treatment in patients with cerebral lesions of the brain.

The task of the invention is to improve the accuracy and objectivity of the evaluation of the effectiveness of orthopedic treatment of patients with concomitant diseases of the neurological profile.

The problem is solved in that in the known method for objective evaluation of the results of the orthopedic treatment of patients with cerebrovascular disease, including hardware method of survey indicators of the patient before and after treatment in patients with cerebral hemodynamics as a hardware method use registration electroencephalogram (EEG), which after treatment with chewing load with 10-20 g of bee comb honey for 3-4 minutes and when restoring or predominance of alpha rhythm in the EEG after treatment assessed as effective.

The present invention meets the criterion of "novelty" and "inventive step", as held patent information research did not reveal sources of patent and scientific and technical expertise, which would discredit the novelty of the proposed method, as well as technical solutions with significant differences of the proposed method.

Know the use of chewing sample in the evaluation of masticatory function in patients with dentition defects (RF patent No. 2258468, publ. from 20.08.2005 year). The known method is that before, during and after orthopedic treatment simultaneously chewing sample, masticatory and registration somatovegetative indicators: arter the social pressure, the heart rate. Based on the data, calculate the index of the adaptive effect of mastication (ice) by the formula

where efficiency is the efficiency of the system chewing, calculated as the ratio of the mass passed through a sieve portion to the weight of the entire test product after chewing

q - the ratio of the minimum blood pressure during the trial and before it,

q is the ratio of the maximum arterial pressure during the test and to her,

qCC - the ratio of the heart rate per minute during the test and to her,

qv is the ratio of the number of chewing movements after implantation and prior to the event,

qt is the ratio of the duration of the chewing period after implantation and prior to the event,

if the index is

for fixed prosthesis- 0,4-0,5,
removable supported- 0,3-0,4,
removable popirayuschie- 0,15-0,2,

the effectiveness of the prosthesis is considered high, and the adaptation process of chewing function is completed; if the index value below about what timema efficiency, you should take measures to improve the quality of prosthetics or increasing adaptive abilities of the organism of the patient.

To estimate power consumption of an organism at different metered loads applied methods, which are based on measurement of parameters of the cardiovascular system. The physiological background of these methods is that any physical work is accompanied by an increase in oxygen consumption, and transport of blood is proportional to the number of heart contractions. Thus, indices of heart rate and blood pressure can serve as objective criteria level of energy and emotional state of the subject in the process of adaptation to dental prostheses, as well as the profitability of the system of mastication.

In the present invention using indicators of functional brain activity.

The EEG rhythms adult waking man:

Alpha (α)-rhythm. The frequency of 8-13 Hz, amplitude up to 100 µv. Logged in 85 to 95% of healthy adults. It is best expressed in the occipital sections, in a direction anterior to the amplitude gradually decreases. The highest amplitude of the alpha rhythm is in the calm state of relaxed wakefulness, especially with eyes closed in a darkened placed the I. Its amplitude, although it is on average relatively constant parameter for a given individual, significantly varies in time. In addition to the changes in the amplitude associated with the functional state of the brain, in most cases quite regularly observed spontaneous changes in the amplitude, the so-called modulation of α-rhythm, expressed in alternating increase and decrease in the amplitude of the waves with the formation of characteristic spindles, the duration of which often varies from 2 to 8 C. When the level of functional activity of the brain (suspense, intense mental work, the feeling of fear, anxiety), the amplitude of the α-rhythm is reduced, and it often disappears completely. On EEG appears high-frequency irregular activity. Automatic analysis shows that in the power spectrum of the EEG disappears dominant peak in α-rhythm and range is flattened with a uniform power distribution across all major frequencies, which confirms the physiological interpretation of this phenomenon as the desynchronization of activity of neurons. In short, suddenly appearing on the background of the rest of the external irritation (especially the flash of light) this desynchronization occurs abruptly, and if the irritation is not emotional nature, occurs quickly (within 0.5-2) Voss is the resolution of α-rhythm.

Beta(β)-rhythm. Frequency 14-40 Hz, amplitude of 15 mV. Best of β-rhythm is logged in the anterior region of the Central convolutions, however, extends to the rear of the Central and frontal gyrus. On EEG, allocated from the scalp, normally it is very poorly defined and in most cases has an amplitude 3-7 mV, i.e. a total of 2-3 times higher than the relative noise level of the amplifier electroencephalograph, and in the presence of EMG artifacts can they fully masked, β-rhythm is associated with somatic, sensory and motor cortical mechanisms and gives response to motor activation or tactile stimulation. When you run or even mental representation of the movement of the β-rhythm disappears in the zone corresponding cortical projection.

Theta(θ)activity. The frequency of 4-6 Hz, amplitude pathological theta activity exceeds 40 µv and often exceeds the amplitude of the normal electrical activity of the brain, reaching under certain pathological conditions 300 µv and more.

Delta(δ)-activity. The frequency of 0.5 Hz to 3 Hz, the amplitude is the same as theta activity. θ and δ-oscillations can in a small amount and at an amplitude not exceeding the amplitude of the α-rhythm, to meet on EEG adult waking man. In this case, they indicate some decline in the level of functional activity of the brain. The pathologist is ical consider EEG, containing θ - and δ-fluctuations exceeding in amplitude 40 mV, which occupies more than 15% of the total time of registration.

The present invention allows to obtain the following effect. This method gives the opportunity to assess the immediate and long-term results of orthopedic treatment removable dentures in patients with cerebrovascular disease. Neurological status of patients before and after orthopedic treatment is an indicator of efficiency in the absence of prosthetic teeth. How informative, simple to execute.

To confirm the positive effect of orthopedic treatment were conducted clinical trials on the basis of the Nizhny Novgorod regional hospital and the Department of prosthetic dentistry GOU VPO Nigga University. Observed patients were divided into groups depending on the stage dyscirculatory encephalopathy:

group 1 - dyscirculatory encephalopathy stage 1 - 50 people.

group 2 - dyscirculatory encephalopathy stage 2 - 45 people.

group 3 - control, consisted of 15 healthy people.

All patients received orthopedic treatment of partial removable dentures. Neurological diagnosis is made on the basis of data from the medical history, examination by a neurologist, cranial dopplerography vessels in the brain, electroencephalography. Dental diag the lake was developed on the basis of the oral cavity examination and radiography. All the data of the clinical examination were recorded in the maps examination of the patient, the dental status was recorded in the dental outpatient patient's record.

More than half of the patients were older than 55 years, and in all age groups marked female predominance. Hospital patients were examined by a neurologist, therapist, ophthalmologist.

All patients carried out the data collection of the history of life and illness complaints at the time of admission, blood pressure measurement on the hands, assessment of neurological, medical and dental status.

All underwent electroencephalography.

Alpha and theta rhythm were recorded in two groups - first and second. In the first group before treatment, the decrease in the amplitude of the alpha rhythm was dominated by one-third of patients, theta rhythm was recorded in individual patients. After the prosthetic treatment with removable partial dentures a few months later, in 70% of patients of the first group was observed recovery of the amplitude of the alpha rhythm. In the second group before treatment, the inhibition of the amplitude of the alpha rhythm was half of the patients theta rhythm recorded in one third of patients of the second group. A few months after prosthetic treatment with removable partial dentures in the second group 40% of patients there was a decrease in the amplitude of alpha-R the TMA and 60% of patients were recorded theta rhythm. In the control group after the chewing load for 3-4 minutes was observed a predominance of alpha-rhythm in 50% of patients, indicators of EEG remained unchanged in the other half of the patients of the control group. Based on the testimony of electroencephalography in all groups it is possible to draw a conclusion about the functional state of the brain, the meaning of which is shown in Fig. 1, 2, 3.

Figure 1 shows the dynamics of the functional state of the brain in the first group of patients after treatment.

Figure 2 shows the dynamics of the functional state of the brain in the second group of patients after treatment.

Figure 3 shows the dynamics of the functional state of the brain in the control group of patients after treatment.

4 shows an orthopantomogram of the patient

The method of objective evaluation of the results of the orthopedic treatment of dental patients with cerebrovascular disease is as follows. Before the start of the orthopedic treatment of the patient with cerebral hemodynamics perform electroencephalographic study and record the performance of the alpha rhythm. After orthopedic treatment EEG study was conducted with the chewing load with 10-20 g of bee comb honey for 3-4 minutes. When you restore the situation or the dominance of the alpha rhythm in the EEG after treatment estimate orthopedic treatment as effective.

Examples of specific performance are given in the form of extracts from the history.

NAME Pestov S.E., 1957 birth.

Diagnosis: partial loss of teeth in the upper and lower jaw.

Complaints: difficulty chewing, lack of teeth.

'an. Morbi:

Patients consider themselves to be about two years, when he lost the side group of the teeth of the lower jaw. Not previously protezirovanija

An.vitae:

Health care for the mouth - regular, once a day, spends tools and hygiene items.

Temporary and permanent teeth portabales in terms corresponding to the physiological norm.

Bad habits - Smoking, for about 10 years.

Background diseases: chronic encephalopathy stage 2.

Nutrition - regular, diet - with a predominance of carbohydrate food.

Occupational hazards none

The mother in pregnancy diseases can not stand.

Hereditary anamnesis is not burdened

Allergic anamnesis is not burdened

Tuberculosis, syphilis, HIV, hepatitis denies.

Patient survey

External examination:

The skin of the face and the visible part of the neck - natural color, marked asymmetry of the face, scars and fistulous passages on the skin there.

Regional lymph nodes are not palpable.

The red border of the lips bright pink, moist, scales, Korach is to and other items of no defeat.

Inspection of the actual mouth:

The mucous membrane of the hard palate is dark red, moderately moist, pathological elements no.

Orthopantomogram (figure 4). Resorption megaloblastnoy partitions on 1/3.

Treatment plan:

1. The sanitation of the oral cavity. Professional hygiene of the oral cavity, replacing old fillings with the new ones.

2. Orthopedic treatment partial dentures upper and lower jaw.

3. Consult a neurologist regarding the treatment of the underlying disease.

Electroencephalography to orthopedic treatment without chewing sample

Opening his eyes

Depression of the alpha rhythm 9% in amplitude. The dominant frequency of 8.7 Hz.

Closing his eyes

The recovery of the alpha rhythm to 90% in amplitude and index, the dominant frequency of 11.5 Hz

Hyperventilation

The amplitude of theta rhythm increased by 30%. Over both hemispheres are visible slow wave theta range in the front-frontal and Central leads.

Conclusion

Severe dysfunction of the median non-specific structures with the interest of the left hemisphere and development paroxysmal States.

Electroencephalography after orthopedic treatment with the chewing load with 15 mg of comb honey for 3-4 minutes.

Opening his eyes

Recovery Alf the-rhythm 4% in amplitude. The dominant frequency of 10.2 Hz.

Closing his eyes

The recovery of the alpha rhythm to 96% of the background amplitude and 90% of the background index. The dominant frequency of 10.1 Hz.

Hyperventilation

The average amplitude of the alpha rhythm increased by 6%

Conclusion

The recovery of the amplitude of the alpha rhythm of the EEG with the chewing load testifies to the effectiveness of orthopedic treatment.

The method of objective evaluation of the results of the orthopedic treatment of dental patients with cerebrovascular disease, including hardware method of survey indicators of the patient before and after treatment, characterized in that in patients with cerebral hemodynamics as a hardware method use registration electroencephalogram (EEG), which after treatment with chewing load with 10-20 g of bee comb honey for 3-4 minutes, and when restoring or predominance of alpha rhythm in the EEG after treatment estimate orthopedic treatment as effective.



 

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EFFECT: higher reliability of prediction.

2 ex, 1 tbl

FIELD: medicine; medical engineering.

SUBSTANCE: method involves doing multi-channel recording of electroencephalogram and carrying out functional tests. Recording and storing rheoencephalograms is carried out additionally with multi-channel recording of electroencephalogram synchronously and in real time mode in carotid and vertebral arteries. Electroencephalograms and rheoencephalograms are visualized in single window with single time axis. Functional brain state is evaluated from synchronous changes of electroencephalograms, rheoencephalograms and electrocardiograms in response to functional test. The device has electrode unit 1 for recording bioelectric brain activity signals, electrode unit 2 for recording electric cardiac activity signals, current and potential electrode unit 3 for recording rheosignals, leads commutator 4, current rheosignal oscillator 5, synchronous rheosignal detector 6, multi-channel bioelectric brain activity signals amplifier 7, electrophysiological signal amplifier 8, demultiplexer 9, multi-channel rheosignal amplifier 10, multi-channel analog-to-digital converter 11, micro-computer 12 having galvanically isolated input/output port and personal computer 13 of standard configuration.

EFFECT: enhanced effectiveness of differential diagnosis-making.

11 cl, 6 dwg

FIELD: medicine; medical engineering.

SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.

EFFECT: wide range of functional applications.

15 cl, 10 dwg

FIELD: medicine, psychiatry.

SUBSTANCE: one should conduct EEG-testing to detect total value of the indices of spectral power or percentage spectral power of delta- and teta-rhythms due to spectrometric technique in frontal, parietal, central and temporal areas both before and during emotional-negative loading when visual emotionally negative stimuli are presented followed by their imaginary reproduction. In case of higher indices to visual stimuli being above 15% against the background one should diagnose epilepsy. The method enables to increase the number of diagnostic means, increase accuracy and objectivity in predicting epilepsy with polymorphic paroxysms at dissociation of clinical and EEG-values.

EFFECT: higher efficiency of diagnostics.

1 ex, 1 tbl

FIELD: medicine, neurophysiology.

SUBSTANCE: one should carry out EEG survey to detect spectrometrically the index of full range if alpha-rhythm both before and after therapy. Moreover, power index of full range of alpha-rhythm and the index of 9-10 Hz-strip's spectral power should be detected in occipital cerebral areas. One should calculate the value of the ratio of the index of 9-10 Hz-strip's spectral power to the index of full range of alpha-rhythm and at the increase of this value by 20% against the background it is possible to evaluate positive result of therapy. The method increases the number of diagnostic means applied in evaluating therapeutic efficiency in the field of neurophysiology.

EFFECT: higher efficiency of evaluation.

1 ex

FIELD: medicine, neurology.

SUBSTANCE: method involves carrying out the standard vascular and nootropic therapy. Diazepam is administrated under EEG control with the infusion rate that is calculated by the following formula: y = 0.0015x - 0.025 wherein y is the rate of diazepam administration, mg/h; x is an average EEG amplitude, mcV. Method provides enhancing the effectiveness of treatment of patients. Invention can be used for treatment of patients in critical severe period of ischemic insult.

EFFECT: enhanced effectiveness of treatment.

2 tbl, 1 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: method involves selecting signals showing patient consciousness level and following evoked auditory potentials as responses to repeating acoustic stimuli, applying autoregression model with exogenous input signal and calculating AAI index showing anesthesia depth next to it.

EFFECT: quick tracing of unconscious to conscious state and vice versa; high accuracy of measurements.

9 cl, 3 dwg

FIELD: medicine; experimental and medicinal physiology.

SUBSTANCE: device can be used for controlling changes in functional condition of central nervous system. Device has receiving electrodes, unit for reading electroencephalograms out, analog-to-digital converter and inductor. Low noise amplifier, narrow band filter linear array which can be program-tuned, sample and store unit, online memory, microcontroller provided with controlled permanent storage, liquid-crystal indicator provided with external control unit are introduced into device additionally. Receiving electrodes are fastened to top part of patient's head. Outputs of electrodes are connected with narrow band filters linear array through electroencephalograph. Output of linear array is connected with input of input unit which has output connected with input of analog-to-digital converter. First bus of analog-to-digital converter is connected with online storage. Recording/reading bus of microcontroller is connected with control input of input unit and its starting bus is connected with address input of online storage. Third control bus is connected with narrow band filters linear array. Second control bus is connected with liquid-crystal indicator. Output bus is connected with inductor. External control (keyboard) of first control bus is connected with microcontroller. Output of online storage is connected with data input of microcontroller through 12-digit second data bus. Efficiency of influence is improved due to getting specific directed influence being based onto general technological transparency of processing of human brain's signals and strictly specific influence based on the condition of better stimulation.

EFFECT: increased efficiency.

3 cl, 1 dwg, 1 tbl

FIELD: medicine, neurology, professional pathology.

SUBSTANCE: one should carry out either biochemical blood testing and electroencephalography or SMIL test, or ultrasound dopplerography of the main cranial arteries, rheoencephalography (REG) to detect the volume of cerebral circulation and hypercapnic loading and their digital values. Then it is necessary to calculate diagnostic coefficients F by the following formulas: Fb/e=6.3-0.16·a1+0.12·a2-1·a3+0.2·a4, or FSMIL=9.6+0.16·a5-0.11·a6-0.14·a7+0.07·a8, or Fhem=48.6-0.04·a9+0.15·a10+13.7·a11-0.02·a12+24.7·a13, where Fb/e -diagnostic coefficient for biochemical blood testings and EEG; FSMIL - diagnostic coefficient for SMIL test; Fhem - diagnostic coefficient for hemodynamic testing; 6.3; 9.6 and 48.6 - constants; a1 - the level of vitamin C in blood; a2 - δ-index by EEG; a3 - atherogenicity index; a4 - the level of α-proteides in blood; a5 - scale 3 value by SMIL; a6 - scale K value by SMIL; a7 - scale 5 value by SMIL; a8 - scale 7 value by SMIL; a9 - the level of volumetric cerebral circulation; a10 - the value of linear circulatory rate along total carotid artery, a11 - the value of resistive index along total carotid artery; a12 - the value for the tonicity of cerebral vessels at carrying out hypercapnic sampling by REG; a13 - the value for the intensity of cerebral circulation in frontal-mastoid deviation by REG. At F value being above the constant one should diagnose toxic encephalopathy, at F value being below the constant - discirculatory encephalopathy due to applying informative values.

EFFECT: higher accuracy of diagnostics.

6 ex, 1 tbl

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