Method for conservative therapy of perforated nasal septum using silicone splints at preoperative stage

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to otorhinolaryngology, and may be used for the preoperative preparation of the patients suffering a perforated nasal septum. Intranasal silicone splints are placed 10 days before the operation. The splint is incised from one side within a perforation border. A 30° endoscope is used to assist a 7-day daily nasal perforation rinsing with chlorhexidine. A suction unit is used to evacuate mucosal secretion; synthomycin ointment is introduced through the incision in the silicone splint to the perforation region. The nasal cavity is irrigated daily with antiseptic and vasoconstrictive preparations. On the 7th day, the intranasal splints are removed.

EFFECT: method enables relieving the mucosal inflammation within the perforation, promotes the prolonged drug retention in the introduction place, ensures avoiding an overlay of a secondary infection, improves the functional state of ciliated epithelium.

2 ex

 

The invention relates to medicine, namely to otolaryngology, and can be used for conservative treatment (preoperative preparation of patients with perforation of nasal septum (MO) in preparation for surgical treatment on the closure of PN.

One of the urgent problems of modern otorhinolaryngology is the problem of the treatment of patients with perforation of nasal septum.

The occurrence of perforation of nasal septum (PPN) may be caused by the development of a wide variety of factors, such as traumatic (injury of the facial skeleton or an isolated injury of the nose in history); iatrogenic (submucous resection of nasal septum with the removal of much of the quadrangular cartilage, rinokhirurgicheskie intervention in the field of the external nose, long transnasal intubation, multiple cryosurgery and cauterization of bleeding vessels in the area Kisselbach plexus); inflammatory (moved hematoma and abscess of nasal septum, chronic atrophic rhinitis), systemic disease (Wegener's granulomatosis) or exposure to corrosive substances (cocaine) (Rmeyer, 1995, Uma and others, 2005, S.Vignesetal., 2002).

Because perforation of nasal septum, especially located in the anterior sections, causes a change in the laminar flow inhaled into the zdwhu on turbulent (P.Cole, 1992) and the deterioration of the normal physiological state of the ciliated epithelium of the nasal mucosa, the obligatory concomitant diagnosis in such patients invariably chronic atrophic rhinitis. Thus there is a further loss of cilia epithelium, crusting, erosions, drying of the mucous membranes, degenerative changes, secondary infection (Rmeyer, 1995). This can lead to chronic perichondritis and further necrosis of the cartilage, and thus further increase the perforation. The presence of a perforation of the septum contributes to drying of the mucous membranes, the development of atrophic rhinitis, the destruction of bone and cartilage framework of the partition.

Methods of surgical correction of perforation of nasal septum does not always give positive results due to improper care of the mucous membrane in the area of perforation of nasal septum in the preoperative period. An essential part of the treatment of the DPU are pre-operative assessment and patient preparation. Rare patients with healthy mucosa and stable in size, are not inclined to increase the DPU. More often PPN with a large number of crusts, with an unpleasant odor and infectious inflammatory process. Mucous membrane, usually loose, bleeds easily and will is seeking in the stage of chronic inflammation. Restoration of the integrity of MO should not begin until until clear cause perforation never happened healing pathologic process or it is not translated into a phase of long-term remission. In the presence of infectious diseases conducting a course of antibiotic therapy. Granulating tissue may indicate a chronic inflammatory or neoplastic process. Biopsy examination and serological tests should be performed when there is suspicion of systemic diseases or pathologies. Inadequate diagnosis and preoperative treatment of the underlying pathological process can reverse the results of the successful recovery of MO and delay necessary treatment of the disease (Clapisson, Gesessen, 1991, J.C.Chalaye, J.Levignac, 1985, I.I.Diamantopoulos, N.S.Jones, 2001).

Some authors (Clapisson, Gesessen) in the preoperative period offer to assign the mode of intensive care of the mucous membrane of the nasal cavity. The patient is informed that he has complied with the toilet cavity of the nose 2-3 times a day with sterile solution "Salina". Softeners type of paraffin oil or ointment "baktroban" can help to reduce the number of crusts in the nasal cavity. The patient weekly supervised by the doctor, he produced inspected and toilet nose. As t is like infection is eliminated and provided good care of your nasal cavity with epithelialization and reduction of crusts, you can proceed to surgical treatment.

The disadvantage of this method is:

- the impossibility of long duration input of a medicinal product in the area of defect of septum of nose;

contact inhaled and exhaled air with the mucous membrane region of the perforation, which prevents full recovery of the mucosa.

There are many ways to hold the septum of the nose in a neutral position, one of which is the installation of intranasal tires, which due to its hardness keep the nasal septum in a neutral position, shielding the mucous membrane of the septum of the nose against mechanical and chemical effects.

Thus, in particular, is known for intranasal bus containing the basis of elastic material, made in the form of plates (patent of Russian Federation №2121309, AV 17/24, 1996), anchored on the nasal septum using a special clamp.

In this analog, provided that in the nasal cavity at the time of treatment nasal insert "ring" tires with holes for passage of air when breathing and form rings, half rings, oval, semi-oval, truncated cone, poluchasa with one flat side surface, or insert bus-plate, or insert a combination of tire-plates with the "ring" tires.

The basis of the significant disadvantages of this are similar to the complexity of the design, consisting of three elements, and the use of such a design requires a physician with special training. The lack of clear dimensions of structural elements associated with the anatomical structures of the nasal cavity, greatly complicates the modeling of the tire. In addition, the results of fixation by bus this design is often unsatisfactory due to the fact that the nasal cavity is covered with mucous membrane, which constantly produces mucus, and design elements will be continuously displaced in relation to the anatomical structures of the nasal cavity. The disadvantages of similar concerns also the use of "ring" tires only for correction of the nasal passages, and their fixation in the nasal cavity at the expense of local tissues, and when this tire is established as if vraspor between a lateral wall of the nose and nasal septum. Pressure by the "ring" tires on the tissues of the nasal cavity, rich in nerve endings that cause the patient discomfort and discomfort. The negative side of this fixation is that on the background of treatment subsides inflammation, characterized by the reduction of edema of the mucosa of the nasal cavity and increase the lumen past, which in turn leads to a flotation nasal tires and a high probability of aspire the AI in the upper respiratory tract. When modeling the nasal tires on the shape and size of common nasal passage", one of the boundaries of which are the nasal septum and roof of the nasal cavity (the latter separates the cavity of the skull)when installing tire of this form is a high probability of iatrogenic injury sieve plates, which leads to the development of renelique and meningitis. The drawback in the analog bus-plate is that its fixation on the columella need a special clamp levers which are located in the cavity of the common nasal passage narrowing the lumen of the latter. The disadvantage of this mounting is that it levers, connecting near the nose (front of the columella), in addition to the inconvenience to the patient, the more difficult the act of otsyrevanija. Also need periodic adjustment of the compression force of the locking clip, which significantly complicates the work of the doctor. Due to the fact that tires plates are designed for "straightening" and "give the correct form of the nasal septum, they are on a limited (curved) section. Thus, there remain areas of the nasal septum, is not shielded by the bus.

The closest solution is the way plastics perforation of nasal septum dimensions of 2.5×3.0 cm custom silicone obturator (H.G.Kempf, H.Weber, 1991). After the formation of the imprint perforation MO in the floor is th plaster form is made obturator. For print use polysiloxan with minor hydrophobic properties, and for the manufacture of the obturator is silicone. Thanks to the free edge in the form of a spout on the edge of the perforation MO under obturator can be applied ointments. Are silicone obturator probably should not be considered as a possible first choice. However, with large perforations that are difficult to close operational method, can be used as a treatment option (H.G.Kempf, H.Weber, 1991). This way we take the prototype. However, in the above method has the following disadvantages:

1 - difficulties in the manufacture of the obturator first formation of the imprint perforation MO, and then its production;

2 - the obturator does not provide complete isolation of perforation of nasal septum from the flow of inhaled and exhaled air;

3 - because of its unreliable fixation possible flotation of the obturator in the nasal cavity.

The purpose of the present invention is the development of conservative treatment for patients with perforation of nasal septum at the preoperative stage.

This goal is achieved by the fact that patients with perforation of nasal septum in the preoperative period in the nasal cavity are the tires made of soft silicone and is the administration of drugs in the area of perforation that sposobstvovali inflammation of the mucous membrane in the specified area, retention of the drug at the injection site for a long time. Resulting in improved prognosis and outcome of subsequent operations (plastics defect).

The technical result of this method is to increase the effectiveness of treatment and reduce the possibility of postoperative complications after closure of perforation of nasal septum. Installation intranasal tires avoids contact of inhaled and exhaled air with the mucous membrane area of perforation of nasal septum, which improves the functional condition of the ciliated epithelium of the mucous membrane, allows you to pause the formation of crusts, erosions in the area of perforation of nasal septum, degenerative changes. Also allows you to avoid joining a secondary infection; to eliminate inflammation in the area of perforation.

The claimed method allows the preoperative period (before plastic surgery perforation) to conservative treatment to combat the signs of inflammation of the mucous membrane in the area of perforation of nasal septum, which increases the efficiency of surgical treatment and also reduces the risk of postoperative complications.

A description of how patients with perforation of nasal septum (sizes ranging from 1*0.5 cm to 2*1.5 cm) as preoperative preparation in the 10 days prior to the planned surgical treatment plastic perforation of the septum of the nose under local anesthesia (lidocaine 1% infiltration and lidocaine 10% of the application) in both halves of the nose get on the same bus with fixed threads on choanal ends of the bus. Specified intranasal bus contains the basis of silicone rubber with a shore hardness a-60, made in the form of plates with a thickness of 1-2 mm semihollow shape in the plan (Russian Federation patent RU 2414180, 2011). Model (suitable for most patients) plate has the following parameters: the interior angles of septangle are: ∠A=165°, ∠B=75°, ∠B=125°, ∠D=163°, ∠D=169°, ∠E=113°, ∠W=90°, the site of convergence of the edges and corners of the plate obtuse, mostly rounded, and the length of the sides is equal to: AB=15 mm, BV=21 mm, VG=17 mm, DG=16 mm, DE=32 mm, HEDGEHOG=12 mm, MS=50 mm Tyre, in some cases, their execution may have on their surface a hollow valikoobraznye thickening, running throughout intranasal tires on the level of the lower turbinate and oriented to the lateral wall of the nasal cavity. This bus provides a secure fit without the use of additional tools and preservation of nasal breathing by the patient due to the fact that the shape of the tire in the form of semihollow plate and its size is determined in accordance with the described in this similar way. Optionally, if no suitable bus with typical dimensions specified above, may be an individual selection of shapes and sizes intranasal tires according to the similar method as for children and for adult contingent bol is different.

Simultaneously with the institution of tire threads under endoscopic control throw through the opener on the opposite half of the nose and transseptal through the tire fixed in the anterior, with choanal the end of the bus set at the level of the distal edge of the nasal septum. Also impose additional U-shaped seam that secures the tire in the anterior and make a cut in the tire with one hand in the area of edge perforations for the subsequent introduction of drugs. This results in a tight fixation of intranasal bus all over the columella. Tamponade of the nasal cavity after the operation is not performed. After the manipulation daily for 7 days consecutively through the region of the septal incision in the bus under the control of the endoscope 30 is washing the area of perforation chlorhexidine, using suction removes mucous discharge, the introduction of syntomycin ointment through the incision in the silicon bus to the area of perforation. Daily patient self-made irrigation of the nasal cavity antiseptic and vasoconstrictor drugs. On the 7th day of the tires removed.

Specific example No. 1

Patient A., age 18, number, case history No. 0956, was admitted with a diagnosis of perforation of the septum of the nose to the plan is the first surgical treatment, with complaints of nasal breathing, the formation of crusts in the nose, wheezing.

From the anamnesis it is known that he considered himself a patient in the course of 3 years, when the patient independently discovered the perforation in the field of nasal septum and appeared above complaints. Not treated.

When holding the front rinoskopii was visualized perforation of nasal septum 1.5∗2,0, look under the edges of the perforation was noted signs of inflammation, erosion, crust. In this connection installed intranasal tires for 10 days before surgery. Made the cut in the tire with one hand in the area of the edges of the perforation. Further daily for 7 days through the region of the septal incision in the bus under the control of the endoscope 30º produced washing the area of perforation chlorhexidine. Using suction conducted daily toilet of the nasal cavity, removing mucous discharge. Through the incision in the silicon bus was introduced syntomycin ointment to the area of perforation. Daily irrigate the nasal cavity antiseptic and vasoconstrictor drugs. On the 7th day of the tires have been removed. Intranasal picture: the mucous membrane in the area of the perforation without signs of inflammation, erosion is not visualized. 3 days after removal of septal tire the patient underwent surgical treatment plastic punching Perigord and nose. The defect in the septum of the nose was successfully closed mucoperiostal flaps. The postoperative period was uneventful. On day 7 after surgery, the patient was discharged from hospital in satisfactory condition. In the late postoperative period, the patient was observed for 3 months. When the front rinoskopii mucosa of the nasal cavity pink, wet, without signs of inflammation. The nasal septum in the midline without defect.

Specific example No. 2

Patient K., 56 years, the number of histories 1238, was admitted with a diagnosis of perforation of the septum of the nose to the planned surgical treatment, with complaints about the formation of crusts in the nose, periodic bleeding from the nose.

From the anamnesis it is known that he considered himself ill for a long time, when the maintenance inspection ENT doctor at the place of residence was identified perforation in the field of nasal septum. Was prescribed course of drug therapy - irrigation of the nasal cavity aerosol akvamaris, oil nose drops. When holding the front rinoskopii was visualized perforation of nasal septum size 2,0∗1.5 cm In the region of the edges of the perforation was noted signs of inflammation, erosion, crust. The patient is installed intranasal tires for 10 days before surgery. Made the cut in the tire with one hand in the field of KRA the perforation. Further daily for 7 days through the region of the septal incision in the bus under the control of the endoscope 30º produced washing the area of perforation chlorhexidine. Using suction conducted daily toilet of the nasal cavity, removing mucous discharge. Through the incision in the silicon bus was introduced syntomycin ointment to the area of perforation. Daily irrigate the nasal cavity antiseptic and vasoconstrictor drugs. On the 7th day of the tires have been removed. Intranasal picture: the mucous membrane in the area of the perforation without signs of inflammation, erosion is not visualized. 3 days after removal of septal tire the patient underwent surgical treatment plastic perforation of nasal septum. The defect in the septum of the nose was successfully closed mucoperiosteal flaps. The postoperative period was uneventful. On day 7 after surgery, the patient was discharged from hospital in satisfactory condition. In the late postoperative period, the patient was observed for 5 months. When the front rinoskopii mucosa of the nasal cavity pink, wet, without signs of inflammation. The nasal septum in the midline without defect.

The LIST of USED LITERATURE

1. Piskunov B.C. Is endonasal anatomical structures in health and disease/ Waseskun // abstract. dis...Kida. the honey. Sciences. - SP is. - 2002. - 22.

2. Piskunov GS Indications for operations on septum of nose, when it should be / Gesessen // 6-th Congress of torinla. The RSFSR. - Abstracts of the reports. 19-21 September. - 1990. - Orenburg. - S-130.

3. Piskunov GS Sequence of surgery in violation of respiratory and aesthetic nasal function and diseases of the paranasal sinuses/ Gesessen // Rosinosakie. - 2003. No. 2. - P.93-94.

4. Piskunov GS ABOUT the physiological role of nasal septum/ Gesessen, Clapisson // News, otorinolaringol. - 2000. - W 6. - P.57-58.

5. Piskunov GS Clinical rhinology/ Gesessen, Clapisson // Moscow. - 2002. - 392 S.

6. Piskunov SZ Diagnosis and treatment of inflammatory processes of the mucous membrane of the nose and paranasal sinuses/ Clapisson, Gesessen // Voronezh. - 1991. - 184 S.

7. Piskunov SZ Morphological and functional features of the mucous membrane of the nose and paranasal sinuses. Principles gentle endonasal surgery/ Clapisson, Gesessen // Moscow. - 1991. - 48 S.

8. Molokov C.V. Perforation of nasal septum - causes and treatment / Moscow 2007/.

9. Diamantopoulos I.L The investigation of nasal septal perforations and ulcers /LLDiamantopoulos, N.S.Jones // J. Laryngol. Otol. - 2001 - Vol.115. - Jf97. - P.541-544.

10. Dklewanger A. Plastik and Rekonstruktion des Nasenseptums/ A.Dirlewanger, R.Meyer // Schweiz. ORL Congress - Delemont, 1968. 122.

11. Hertig P. Closure of septal defects and septocolumellar reconstruction/ P.Hertig, R.Meyer // Excerpta Medica, nt. Congr. Ser. No. 206, Oto-Rhino-Laryngology: Proceedings of the Ninth Intemation Congress, Mexico, August, 1969.

12. Kempf H.-G. Septumperforationsverschlufi durch emen individuellen Obturator/ H.-G.Kempf, H. Weber // Laryngo. Rhino, aol. - 1991. - Bd.70. - S.436-437.

13. Kridel R.W.H. Septal perforation closure utilizing the external septorhinoplasty approach/ R.W.H.Kridel, W.D.Appling, W.K. Wright // Arch. Otolaryngol. Head and Neck Surg. - 1986. - Vol.112. - P. 168-172.

Method of conservative treatment of perforation of nasal septum with silicone tires on preoperative stage by intranasal installation silicone tire, characterized in that for 10 days before surgery set intranasal splints, make an incision in the tire with one hand in the area of the edge perforation, daily for 7 days consecutively through the region of the septal incision in the bus under the control of the endoscope 30º produce washing the area of perforation chlorhexidine, using suction to remove mucous discharge, injected syntomycin ointment through the incision in the silicon bus to the area of the perforation, daily irrigate the nasal cavity antiseptic and vasoconstrictor drugs, on the 7th day intranasal tires removed.



 

Same patents:

FIELD: chemistry.

SUBSTANCE: present invention relates to a method of producing 14-O-[(N-(3-methyl-2-aminobutyrylpiperidinyl)sulphanyl)acetyl]mutilins of formula (I) , which involves removing protection from N-substituted piperidinyl-sulphanyl-acetyl-mutilin of formula (II) , separating the obtained compound of formula (III) and acylation thereof to obtain a compound of formula (IV) and subsequently removing protection and separating a compound of formula (I). The invention also relates to a compound of formula (IV), a methane sulphonate salt of the compound of formula (III), crystalline hydrochloride of 14-O-[(N-3-methyl-2-(R)-aminobutyrylpiperidin-3(S)-yl)sulphanyl-acetyl] mutilin, a method for production thereof and a pharmaceutical composition based thereon.

EFFECT: novel method of producing a compound of formula (I), characterised by low time, resource and labour costs.

18 cl, 2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to novel lipopeptide compound of formula (I) , and to its pharmaceutically acceptable salts, where: R represents: and v represents integer number from 3 to 5. Invention also relates to based on the claimed compound pharmaceutical composition, which possesses antibacterial activity.

EFFECT: obtained is novel compound of formula (I), which can be applied in medicine in form of antibacterial medications against Clostridium difficile.

26 cl, 9 tbl, 20 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely otorhinolaryngology, phoniatrics and physiotherapy and may be used for the integrated treatment of aggravated chronic laryngitis. Starting from the 4-5th day from the aggravation, a standard drug therapy is additionally combined with an endolaryngeal injection of specific pyobacteriophague 1 ml and further exposure to low-frequency vibration covering 3 fields of the larynx and phonopaedic breathing exercises. The low-frequency vibration starts at a first filed comprising side neck surfaces at frequency 20 Hz per 1 filed with a vibratode advanced smoothly upward at 2-3 mm/sec with undisplaced skin and rectangularly up to a mandibular angle, and then downwards to a posterior triangle of neck for 1-2 minutes from each side; the patient does the phonopaedic breathing exercises and pronounces expiratory 'M'; that is followed by the vibrational exposure covering a projection of intersection of a thyroid cartilage plate and a border of sternocleidomastoid muscle (m.sternocleidomastoideus) at a thyroid cartilage notch at frequency 40 Hz and 60 Hz for 1-2 minutes from both sides according to the stable technique; the patient does the phonopaedic breathing exercises and pronounces expiratory vowels 'U', 'O', 'A'; that is followed by vibration of a collar at frequency 30-40 Hz with the vibratode advanced from a paravertebral line to a shoulder joint for 2-3 minutes from each side; the technique is labile. The course performs 8-10 combined daily procedures.

EFFECT: method enables higher clinical effectiveness ensured by the integrated effect on the patient's immune system in a combination with the drainage, anti-inflammatory, and trophic stimulating effects.

11 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine. What is presented is a vaccine against pneumonia caused by Streptococcus pneumoniae, on the basis of a hybrid protein described by SEQ ID NO:1, containing fragments of the proteins Streptococcus pneumoniae PspA, Sprl 895, PsaA, as well as the ingredients of flagellin as an adjuvant, connected by flexible bridges.

EFFECT: invention provides the effective prevention and therapy of pneumonia ensured by the fact that the vaccine hybrid protein is composed of various immunogenic epitopes eliciting a specific immune response with formed immunological memory.

4 dwg, 8 ex

FIELD: medicine.

SUBSTANCE: invention relates to veterinary science, namely to obstetrics and gynaecology. A preparation for treating and preventing sub-clinical, clinical, acute and chronic mastitis in farm and domestic animals contains an active substance that is - triphenyl-(3,5-di-tert-butyl-4-hydroxybenzyl)phosphonium bromide and a pharmaceutically acceptable carrier that is Vaseline in ratio 1:2000.

EFFECT: invention provides the higher antimicrobial effectiveness and the lower toxicity of the ointment with the lower concentration of the active substance.

3 tbl, 5 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention discloses an immunogenic composition having an immunogenic activity on serogroup B and C Neisseria meningitidis containing (a) N. meningitidis serogroup C (NmC) oligosaccharide, (b) proteoliposome vesicles of the outer membrane of N.meningitidis (NmB) serogroup B and (c) NmB protein containing and an amino acid sequence presented in the description, or an immunogenic fragment of the above sequence, or a sequence min. 80% identical to the above sequence. The ingredient (a) may be conjugated with a carrier, e.g. with a protein, CRM197, a diphtherial anatoxin or a tetanus anatoxin. The immunogenic composition can contain aluminium hydroxide or MF59 as an adjuvant. What is described is a N.meningitidis serogroup B and C vaccine containing the described immunogenic composition.

EFFECT: using the invention enables preparing the combined vaccine eliciting an immune response on both serogroups of the agent.

6 cl, 4 dwg, 5 tbl, 6 ex

FIELD: medicine.

SUBSTANCE: invention refers to fishing industry, and can be used in treating young sturgeon pseudomonosis. A method of treating sturgeon pseudomonosis by individual intramuscular injections of an antibacterial preparation that is presented by cefazolin with a two-stage injection schedule; one day after the first introduction, all subjects are injected with the preparation; if observing a moderate severity, the first introduction includes a dose of 50 mg/kg of body weight, while the second introduction - in the amount of 25 mg/kg of body weight, while the severe disease involves the first introduction in a dose of 100 mg/kg of body weight, and the second introduction in a dose of 50 mg/kg of fish body weight; further the affected fish is fed with a production food with VITAN+ probiotic added; the fish is fed one day and a half later after the beginning of the treatment.

EFFECT: providing fast and complete recovery of surgeons, especially having a severe bacteriosis affection.

2 cl, 1 tbl, 4 ex

FIELD: biotechnologies.

SUBSTANCE: mutant strain is obtained by impact on Glarea lozoyensis ATCC 20957 strain by nitrosoguanidine and it is deposited in CGMCC with number CGMCC 2933.

EFFECT: fungi strain has stable genetic and productive properties, produces low quantity of impurities during fermentation and is acceptable for commercial production of antibiotic.

6 cl, 2 dwg, 2 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, and aims at treating acute pyelonephritis in children. The method involves a combination therapy with antibacterial and antioxidant preparations. That is ensured by measuring the pre-therapeutic generation of active oxygen forms (AOF) by whole capillary blood leukocytes using luminol-dependent chemicoluminescence stimulated by barium sulphate crystals, and serum antioxidant content (AOC) by chemicoluminescence activated by rhodamine G in the presence of ferrous iron ions. If the AOF level is more than 2.70×105 quanta/s × 4π, the AOC level is below 29 relative units, a combination therapy with an antibacterial preparation and Canephron N in an age dosage is prescribed for 14 days. On the 14th therapeutic day, the AOF and AOC levels are determined in the patients receiving the combination therapy. If the AOF level is below 2.70×105 quanta/s × 4π, and the AOC level is above 29 relative units, the therapy is terminated. If the AOF level is more than 2.70×105 quanta/s × 4π, the AOC level is below 29 relative units, the Canephron N therapy is continued in the age dosage for another 14 days.

EFFECT: method is simple and high-effective in treating acute pyelonephritis in children.

3 ex

FIELD: chemistry.

SUBSTANCE: present invention relates to novel lantibiotic amide derivatives 97518 and use thereof.

EFFECT: present invention describes a compound of general formula (II) and use thereof as an antibiotic.

19 cl, 6 tbl, 7 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to surgical dentistry and maxillofacial surgery, and is applicable in maxillary sinusotomy with fistula repair. A mucous membrane is incised to a bone under an intubation narcosis after a two-fold preparation of a surgical area. A D-shaped flap is cut out within an alveolar socket of an extracted tooth to be extended along a mucobuccal fold of an upper jaw on one side to a second incisor, and on the other side - to a third molar. The flap together with the periosteum is separated and retracted upwards with exposing a canine fossa and the alveolar socket of the extracted tooth. A hole is created within the canine fossa. Pathologically changed tissues or all sinus mucosa is scooped with a bone curette through the created hole. The alveolar socket of the extracted tooth is inspected. After the cavity has been scooped, an artificial hole is created towards a nasal cavity through an inferior nasal meatus. The sinus cavity is packed with a iodoform cotton swab; an end of the cotton swab is laid thoroughly on a sinus bottom, namely within the defect; the end of the cotton swab is brought out into a nose. A mucoperiosteal flap is mobilised within the alveolar socket of the extracted tooth, laid on the alveolar socket; the wound is closed completely. In the postoperative period, the cotton swab is removed from the sinus on the 9-10th day. The sutures are removed on the 10-11th day.

EFFECT: method enables reducing an incidence of recurrent oroantral communications in the postoperative period ensured by a compact packing of the sinus, and the antiseptic and regeneration effect of iodoform on the maxillary sinus.

2 ex

FIELD: medicine.

SUBSTANCE: invention relates to veterinary science, namely to obstetrics and gynaecology. A preparation for treating and preventing sub-clinical, clinical, acute and chronic mastitis in farm and domestic animals contains an active substance that is - triphenyl-(3,5-di-tert-butyl-4-hydroxybenzyl)phosphonium bromide and a pharmaceutically acceptable carrier that is Vaseline in ratio 1:2000.

EFFECT: invention provides the higher antimicrobial effectiveness and the lower toxicity of the ointment with the lower concentration of the active substance.

3 tbl, 5 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to an antiseptic drug with haemostatic action for wound cleaning. The drug contains ingredients in the following ratio, wt %: an antimicrobial substance - 0.01-3, an active complex - 1-25, glycerol - 2-35 and water - up to 100. The antimicrobial substance is specified in a group consisting of cetyl pyridinium or cetyl methyl ammonium halogenide, chlorhexidine, miramistin and other quaternary bases applicable in medical practice to treat burns and to clean open wounds, and the active complex is presented by a haemostatic preparation in the form of a mixed-ligand chelated complex of zinc, ethylene diamine tetraacetic acid and ε - aminocapronic acid. The invention also refers to a method for preparing the antiseptic drug with haemostatic action. The method consists in the fact the active complex is prepared in a water-glycerol mixture while stirring by dissolving ε - aminocapronic acid, then zinc oxide, adding powdered ethylene diamine tetraacetic acid and after dissolved completely, adding a liquid solution of the antimicrobial substance in the water-glycerol mixture.

EFFECT: preparing the antiseptic drug with haemostatic action for wound cleaning.

2 cl, 9 ex

FIELD: medicine.

SUBSTANCE: invention refers to pharmaceutical industry and represents a preparation possessing the anti-inflammatory action, stimulating the mucosa regeneration, and containing magnesium-chloride mineral bischofit brine 1.27±0.01 g/ml with normalised specific gravity, slastiline, menthol, thymol, and a stabilising agent differing by the fact that it contains magnesium-chloride mineral bischofit brine free from technogenic impurities, with the ingredients in the preparation are taken in specific proportions, g.

EFFECT: reducing acute daily oral toxicity in 1,7-1,9 times.

1 tbl

FIELD: biotechnologies.

SUBSTANCE: invention refers to derivatives of oxazolopyrimidine in any of their stereoisomeric forms, or in the form of a mixture of stereoisomeric forms specified in Claim 1.

EFFECT: oxazolopyrimidine derivatives having agonistic activity in relation to Edg-1 receptor.

5 tbl, 319 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to general surgery, and can be applied in prevention of purulent-inflammatory complications of anterior abdominal wall wounds in case of strangulated ventral hernias. For this purpose, 10% solution of colloidal nanosilver is introduced into operation wound after elimination of strangulation, with preliminary injections on perimetre of hernial orifice edges in dose 0.1 ml of solution per 1 cm2 of aponeurosis. After that, after fixation of synthetic implant, injections are made along the line of sutures on periphery in dose 0.1 ml per 1 cm2 of suture. After that, subcutaneous adipose cellular tissue is infiltrated with solution of colloidal nanosilver in dose 0.1 ml of solution per 1 cm2 of wound.

EFFECT: method ensures considerable reduction of risk of development of purulent-inflammatory complications in patients with said pathology, as well as acceleration of processes of tissue reparation due to application of biologically active colloidal solution of nanosilver, producing selective impact only on pathogenic microorganisms, on all layers of anterior abdominal wall and zone of synthetic implant fixation.

5 cl, 1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely purulent surgery, and may be used for treating infected wounds. That is ensured by surgical treatment of suppurative focuses and exsection of necrotised tissues. Then the whole wound surface is treated with 10% colloidal nanosilver. The subcutaneous fat is infiltrated with 10% colloidal nanosilver at 0.1 ml of the solution per 1 cm2 of the wound. Additionally, the wound is covered with a sterile 10% colloidal nanosilver wipe.

EFFECT: method enables reducing the length of wound granulation and epithelisation ensured by using the biologically active colloidal nanosilver solution coating all wound layers and rendering selective action on pathogens only.

1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, specifically to an agent showing antimicrobial activity.

EFFECT: agent possessing antimicrobial action and representing robinia (Robinia pseudaacacia L) seed essence prepared by collecting the seeds in October and extracting them three times in petroleum benzene under certain conditions.

2 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to medicine, particularly to ophthalmology. One of the objects is using 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diole (compound A), its separate isomers and a mixture of the same isomers, or pharmaceutically acceptable salts, solvates and hydrates thereof for preparing an agent for treating keratoplasty or refractive keratoplasty consequences. The second object is a method of treating the keratoplasty or refractive keratoplasty consequences in an individual in need thereof that involves administering a therapeutically effective amount of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diole (compound A), its separate isomers and mixtures of the same, pharmaceutically acceptable salts, solvates and hydrates thereof into the above individual.

EFFECT: invention provides treating the eye disorder consequences.

2 cl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, and may be used for treating septic wounds and burns. A composition possessing antibacterial action contains active metal biocomplexes with 5-nitroimidazole and β-pyridine carboxylic acid and a base providing a soft dosage form. As a gelling agent, there may be used modified cellulose derivatives, additionally comprising methyl monosilane hydrogel (enterosgel) and/or polyvinylpyrrolidone, or an alloy of polyethylene oxide-400 and polyethylene oxide-1500. As a mixture of hydrophilic substances, the base contains substances specified in a group of: polyethylene oxides, dimexide, glycerol and aerosol, may comprise at least one target additive of: anaesthetic - trimecaine, pyrromecaine, lidocaine, or a mixture thereof, a repair process stimulator - methyluracil, acemine, solcoseryl, Spirulina microalgae (Spirulina platensis), or a mixture thereof, antiseptic - miramistine, chlorhexidine digluconate, dioxidine or a mixture thereof. The composition is presented in the form of an ointment or gel.

EFFECT: invention provides the improved microcirculation in wound tissues, as well as anti-inflammatory action, repair process stimulation.

5 cl, 6 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: throat tonsil is treated with octenisept dissolved in 0.9% saline in ratio 1:10. The treatment involves right and left nostrils alternately for 3 seconds 30-40 times for 6-10 minutes. The treatment is combined with the ultrasonic exposure generated by Sonoka 180 at frequency 20-40 kHz. The therapeutic course is 6-7 sessions, either daily or every second day.

EFFECT: fast nasopharyngeal sanitation, reduced local inflammatory response, improved nonspecific resistance of the throat tonsil at enhancing the humoral immunity factors that in turn improves the quality of life of these patients.

3 ex

Up!