Water-resistance ecg monitor and user interface

FIELD: medicine.

SUBSTANCE: invention relates to medical equipment. An ECG monitor of a cardiac monitoring system for outpatients comprises rechargeable battery in a nonconductive water-resistant case, a processor for processing the patient's ECG signals, a processed ECG signal memory, a wireless transceiver coupled to the processor and used for wireless ECG signal transmission to a receiver, a user interface and a power circuit. The user interface is provided on an outer side of the case, electrically connected with the components in the case and only includes a number of electric pins. The power circuit is designed to detect the connections of ECG monitor contacts with an external charging dock and detecting an electrical connection of the ECG monitor for receiving the patient's ECG signals. The power circuit is also used to switch ECG monitor to a low-power mode when the ECG monitor is not connected for receiving the patient's ECG signals and is not connected for charging the battery. The power circuit provides switching the ECG monitor to a high-power mode in response to detecting the charging connection.

EFFECT: using the invention provides the waiting mode control in response to the charging connection detected.

6 cl, 38 dwg, 1 tbl

 

This application is an application form, partially still pending international application PCT/IB 2006/054019, filed October 30, 2006, which claims the priority of provisional patent application U.S. 60/741492, filed November 30, 2005.

The technical field

The present invention relates to systems ECG monitoring and, in particular, continuous ECG monitoring of patients in the outpatient setting.

Prior art

Many patients have expressed the need for continuous monitoring of the heart over an extended period of time. This group of patients includes those patients that may have an arrhythmia, such as atrial fibrillation, atrial flutter and other supraventricular tachycardia, and trialnew or the ventricular ectopia, bradyarrhythmia, alternating blockade feet atrioventricular bundle and arrhythmias associated with such pathological conditions like hyperthyroidism or chronic lung disease. Other patients may experience symptoms that can be caused by cardiac arrhythmias, such as dizziness, fainting or shortness of breath. Other patients may experience palpitations, in which the patient may be required to adjust the rhythm depending on the symptoms of other conditions patients may need to monitor the effects of drugs on heart function in those situations, when you want to track arrhythmic effects of drugs or the effects of drugs aimed at suppressing arrhythmia. For drugs with known arrhythmic effects you want to monitor the possible prolongation of the QT interval. For patients with a diagnosis of respiratory disorders during sleep, for example suffering from apnea during sleep, stroke or transient ischemia, or recovering after heart surgery, often it may be convenient to use a continuous monitoring of the heart.

At present some of these States use multiple monitoring devices. The Holter heart monitor is used for continuous recording of the electrocardiogram of the patient during, for example, a 24-hour period. However, the data recorded by Holter cardiac monitor, only recorded and can be analyzed only after the end of the registration period. Direct ECG analysis is not possible when ECG data only registered and are not reported immediately. In addition, many patients feel limited in her ability to do daily chores while wearing the Holter cardiac monitor and the presence of numerous wires and electrodes, and often oppose the discomfort and inconvenience of these heart monitors.

The other is named device for monitoring, currently applied, is the loopback recorder or Registrar of event ECG. Loop recorder is recording with continuous recording of ECG events. When the loop is completed, loop recorder overwrites the previously recorded data. Therefore, the loopback recorder ineffective as a Registrar for a full report over a long period of time, as data may be lost. With the event recorder ECG patient is connected to the set of electrodes and wires, and the event recorder can be activated by the patient whenever the patient feels the typical symptoms. When the patient feels pain or discomfort, the patient activates the event recorder to make a recording of the ECG during symptom. Some monitoring systems also allow you to send ECG data to the local base station, which transmits ECG data on the phone in the diagnostic center, where they can be quickly analyzed for the presence of arrhythmias. However, this limits the normal daily activities of the patient, since the patient must be continuously remain within reach of the local base station.

Other heart monitors appointed by the Registrar, which is automatically activated when the cardiac event to run Zap the si ECG during the event. The patient then connects the cardiac monitor to a telephone modem for transmitting ECG data in the control center for the study. These systems have numerous disadvantages. One of them is that the error of the patient when connecting the cardiac monitor to the telephone equipment or equipment can result in the loss of the loaded data. Another disadvantage is that the cardiac event, such as fainting, may lead the patient to loss of consciousness or disorientation and inability to perform the boot process correctly or, in some cases, to the failure load. In addition, if the cardiac event occurs at the moment when the patient moves in the car, it may take considerable time before the patient will return to the location of the equipment to send data and will be able to perform the process of sending data.

A brief statement of the substance of the invention

Thus, the present invention is the creation of a monitoring system of the heart, which overcame the disadvantages of the described devices. Such a cardiac monitoring system could continuously record the electrocardiogram of the patient, analyzing the ECG for arrhythmias in real time and send ECG data to the clinical doctor for di the Gnostics each time when the detection of potentially significant arrhythmia. The system could also be operated by the patient to record symptomatic events, preferably with a verbal description of the event, and then automatically send a description of the symptom and related data ECG clinical physician or control center for analysis. The monitoring system preferably would be very comfortable and convenient for the patient without disturbing the normal daily activities of the patient.

In accordance with the principles of the present invention proposed system ECG-monitoring, which is completely wireless for the comfort and convenience of the patient. Small cardiac monitoring with the possibility of withdrawing connected to the electrodes attached to the chest of the patient using an adhesive material. Cardiac monitoring continuous processes and records the ECG of the patient, and also analyzes the ECG for arrhythmias. If the estimated arrhythmia is detected, the strip of ECG data immediately wirelessly sent to the mobile phone and sent to the monitoring center for clinical analysis. The cardiac monitor was placed in a sealed plastic casing and, thus, is waterproof, so it can be worn in the shower. The only external components or UI cardiac monitor is a number what about the electrical contacts. The electrical contacts provide the interface through which the cardiac monitor receives ECG signals from electrodes of the patient, and cardiac monitor battery can be recharged.

The invention is further explained in the description with reference to the drawings, in which:

figure 1 depicts a patient with dressed system ECG-monitoring according to the invention;

figure 2 - adhesive contact electrode, which is attached to the chest of the patient and holds the ECG monitor;

figa and 3b - front and rear views ECG monitor of the present invention, which are attached to the electrode 2;

figure 4 - installation option ECG monitor on the adhesive contact electrode figure 2;

figure 5 - handset system ECG-monitoring of the present invention with the cover;

6 - handset mobile phone 5 with cover, mounted on a mobile phone;

7 is a horizontal projection of the anterior part of the cell-phone when the handset is connected to a cardiac monitor;

figa-8i - some of the images displayed normal cell-phone systems ECG monitoring according to the invention;

Fig.9 - charger docking station of the cardiac monitor and cord for charging cell-phone;

figure 10 - cardiac monitoring in the charging dock Fig.9 before closing the cover, charging dock;

11 - Ariadna dock set system ECG-monitoring of the present invention, used for charging a cardiac monitor and cell-phone;

figa functional block diagram of ECG monitor, constructed in accordance with the principles of the present invention;

fig.12b - block diagram the functions of the ECG monitor figa on the basis of a promising equipment;

Fig functional block diagram of a handset of a mobile phone associated with the control center;

Fig - illustration of relationship between ECG monitor and control center, as well as their function in the system ECG-monitoring according to the invention;

Fig - screen display template configuration settings and limits alarm ECG monitor according to the invention;

Fig - screen display for configuration procedures and limits alarm ECG monitor of the present invention shown with custom alarm;

Fig - screen display, used to link the components of the set of ECG monitoring according to the invention;

Fig - screen display that is used to track the location of sets of ECG monitoring according to the invention;

Fig - screen display used to monitor ECG monitor and Bluetooth addresses according to the invention;

Fig - screen display that is used to track the use of ECG monitors according to izobreteny is;

Fig - screen display that is used to track handsets mobile phones, their phone numbers and Bluetooth addresses according to the invention;

Fig - screen display that is used to track the handset ECG according to the invention;

Fig - computerized template that is used to register the appropriate provisions to accommodate the adhesive contact of the electrode and orientation of the adhesive contact regarding a patient;

Fig - setting screen is used for programming to create reminders to the patient to recharge the cardiac monitor and cell-phone systems ECG monitoring according to the invention;

Fig - screen display used by the monitoring centre for the registration requirements of the doctor for messages in the process of applying systems ECG monitoring according to the invention;

Fig - screen display for monitor speakers account in the process of applying systems ECG monitoring according to the invention;

Fig - screen display of the log data of the patient during the procedure ECG monitoring according to the invention;

Fig - screen display program to view ECG used for outputting data received from four-channel ECG monitor, according to the invention;

Fig - screen display program to view ECG, p is odnaznachno for ECG monitor of the present invention, deployed Windows notifications and events;

Fig - screen display alerts on the status received from the ECG monitor according to the invention;

Fig - screen display program to view the ECG with the magnification window for a detailed examination of the shape of teeth, ECG according to the invention;

Fig - block diagram of the configuration method of procedure ECG monitoring according to the invention;

Fig - block diagram of the operations of method the initial installation of the ECG monitor to the patient according to the invention;

Fig - block diagram of the operations of method daily withdrawal and charging ECG monitor according to the invention;

Fig - block diagram of the operations of the method of application click "help" on the mobile phone handset system ECG-monitoring according to the invention;

Fig is a flowchart of operations of a method of using the button "voice Recording" on the mobile phone handset system ECG-monitoring according to the invention;

Fig is a flowchart of operations of way voice contact with the patient to resolve the difficulties, which informs the system of ECG monitoring, according to the invention;

Fig - block diagram of the actions performed by the repair center in preparation systems ECG monitoring of the present invention for use by another patient.

Description of the variants of embodiment of the invention

Figure 1 illustrates the essential is patient comfort and convenience in the use of wireless systems ECG monitoring, designed in accordance with the principles of the present invention. People engaged in their daily business without being disturbed and limited continuous operation of the system ECG-monitoring, which he wears. This is because the system ECG-monitoring, which he wears, is thin, lightweight and so comfortable to wear. Mainly, this is due to the fact that the system ECG-monitoring does not have any wires that hang on the body. Wires do not depart from the monitor to the electrodes on other parts of the body, no wires connecting the cardiac monitor with your device, and there are no wires connecting the device to a communications network. System ECG monitoring is completely wireless. The casual observer may only seem that a person carries a mobile phone carrying case 10, which is attached to the hip of the person. On the chest of the person is shown a wireless ECG monitor 12 of the present invention. Although the location of the ECG monitor 12 shown in figure 1, in fact, the cardiac monitor will be invisible to the observer, as it will be under the shirt of the person. When the diameter is less than 2.5" (6.3 cm), the thickness of 0.5" (1.3 cm) and weight less than an ounce (28,35 g) cardiac monitoring will be virtually invisible under clothes. While people are busy with their daily activities, ECG monitor 12 n is discontinuously tracks, analyzes and records the ECG with each heartbeat. If a cardiac monitor detects an arrhythmia, the alarm signal and the ECG strip wirelessly sent to a mobile phone handset, located in the carrying case 10. The handset silently communicates with the monitoring center, which can be hundreds or thousands of miles, and transmits the alarm signal and the ECG strip to the monitoring center. In the monitoring center received ECG data quickly sees the doctor and taking any necessary action or sends a message to the physician of the patient. Cardiac function of the patient is checked, therefore, within 24 hours a day, usually within a few weeks (for example, 10-30 days), providing archival ECG information and providing a level of protection against arrhythmias that otherwise would not be available in the outpatient setting.

Figure 2 shows the adhesive contact electrode 20, suitable for use with a wireless ECG monitor of the present invention. Specified adhesive contact and its variants are described in detail in the publication of the initial application WO 2007/063436. Figure 2 is a view of the outer side of the adhesive contact 20. Adhesive contact is formed from a flexible base 22. On the rear side (the side facing the patient) adhesive contact are four guide is agaevyh contact electrode s1, s2 and s3, as well as the Central contact electrode, not visible in this drawing. Central contact electrode is a control or RLD electrode, so named because of its analogy with the control electrode of interference compensation (right leg drive (RDL)) standard ECG device. The rest is converted to the patient side adhesive contact 20 is covered with a biocompatible adhesive that securely fixes the adhesive contact on the chest of the patient. The electrical signals are taken from three contact electrodes s1, s2 and s3 connected to the electrical contacts on the outer side of the adhesive contact of the flexible circuit, as described in the initial application, the signals, thus obtained, are used to form the three main vectors of ECG, as described below. In the centre of adhesive contact on the outer side, is the plastic clip 24 with curved protrusions at the top and bottom, which can be installed and secured ECG monitor, as shown in figure 4. In the center of the clamp 24 is the number of elastomeric contacts 26 through which the electrical signals received on the contact electrodes s1, s2 and s3 are transmitted to the ECG monitor, while the control signal generated by the ECG monitor, associated with the RLD electrode to control loose electrodes and the suppression of common mode noise.

On figa shows the horizon is supplemented flax projection outwards of the front side of ECG monitor 30, designed in accordance with the principles of the present invention. ECG monitor 30 is enclosed in a plastic butterfly case, sealed by ultrasonic welding or hermetically bonded with glue or solvent. On the back side 38 of the housing, as shown in fig.3b, there are a number of electrical contacts 36, which is inserted in the housing and thermally welded flush with the surface of the housing. In the described embodiment, there are three rows of electrical contacts 36. One of these series provides communication with the elastomeric contacts 26 of the clamp 24 and enters the ECG signals to the cardiac monitor, and takes the weak signal on the control electrode. The other two series are connected with the respective rows of contacts in the charging dock when the cardiac monitor 30 charge, as described below. Cardiac monitoring in this example does not have any external controls or displays, and has no switch, but only the electrical contacts 36 on the back side of the case. In this embodiment, the ECG monitor has a width of 2.4" (6 cm), height of 1.9" (4.8 cm), a thickness of 0.5" (1.3 cm) and weighs a 0.9 oz (25,5 g). Because the case is sealed at the periphery, and the contacts on the back side is completely sealed, cardiac monitoring can be worn in the shower without any danger to the patient or cardiac monitor. As the case in the data is m embodiment, the closed permanently, replace the internal battery or components in this design impossible. If a cardiac monitor may not work properly or the battery no longer holds a sufficient charge, the cardiac monitor disposed of properly.

The plastic housing at the bottom part has a recess 32 which conforms to the shape of the lower part of the clamp 24 and the adhesive contact of the electrode 20. In the lower part of the body is also formed recess 34, which corresponds to the ledge at the bottom of the clip. Example fig.3b has two recesses 34a and 34b for landing on the appropriate tabs of the clip 24 of adhesive contact. This mount allows you to install ECG monitor 30 in the clamp 24 in only one position. Figure 4 shows a side view, showing the cardiac monitor 30, which is installed in the clamp 24. First clip is inserted into the lower part of the cardiac monitor figa, with mounting 32, 34 on the lower part of the cardiac monitor fixed on the lower part of the clamp with the appropriate form. Then the upper part of the cardiac monitor tilts back to the top of the clamp, as shown by the arrow in figure 4, and the upper part of the cardiac monitor is fixed under the upper part 28 of the clamp 24. As soon as the cardiac monitor falls into place, providing a tactile indication to the patient that a cardiac monitor is in place, the contacts 36 on the back of the cardiac monitor combine the camping and inserted into the row of pins 26 on the clamp. Now the cardiac monitor is in working position and can monitor the patient's ECG waveform, which begin to register immediately after a cardiac monitor detects the specified number of contacts interrupts the standby mode and is included in full readiness for operation.

Figure 5-7 shows the handset 50 suitable for use with ECG monitor 30 with figure 3. The handset 50 includes a standard commercially available "smart phone" 52, on which is placed a plastic cap 56, which are secured in place. Cover 56 covers the majority of the buttons of a standard mobile phone and restricts patient using only a few buttons, the necessary procedures for ECG monitoring. Thus, the cover turns, as a rule, complex commercial mobile phone into a device that is simple for the patient to understand and use. Figure 5 shows a mobile phone 52, is placed in the cover 56. The switch button 54 is located on the side of the mobile phone 52, while the mobile phone 52 is enabled before installing it covers. As shown in Fig.6, the cover 56 has a hole on the front side, the size of which corresponds to the size of the screen of the mobile phone so the screen 58 of the mobile telephone 52 can be seen through the hole in the lid. Cover techeilet two cutout 62 and 64 on the front. These cutouts 62, 64 can be pressed by the patient as control buttons the two buttons underneath the keys on the keypad of a mobile phone. In other versions the cover can close most keys, mobile phone and leave only some keys are open and available for use. Cutouts or open control keys like "touch keys", and functions that are affected by pressing at any time are displayed on the screen 58 of the mobile phone, at the bottom of the screen directly above each cutout. Depending on the mode of operation of the monitoring system and actions of the patient these functions are modified as described below. 7 shows a front view with the cover closed tube mobile phone, showing the screen 58, the buttons under the screen, a small hole 72 in the upper part of the lid, through which the patient can hear the earpiece of a mobile phone, as well as three small holes 74 in the lower part of the cover 56, through which the patient can speak with the voice message or the conversation with the monitoring center, as described below. In this embodiment, when the mobile telephone 52 is on and the cover 56 is installed in place, the patient can manage only two buttons 62 and 64.

A significant advantage of this commercial mobile phone the background with the use of cover is the monitoring system can be quickly and inexpensively adapted to the new technology of cellular communication. When new and the obsolescence of the previous models of mobile phones new mobile phone model can be used after updating the design of the cover for the new model and low-cost production of the new cover in large quantities, in the form of parts made, for example, by injection molding. Costs and the cost of such production is much less than that required for the development and production of customized mobile device that is not falling behind technological progress and was expensive for smaller production runs. The approach of the invention adapting the new cover to new commercial models of mobile phones allows the developer system monitor to use the advantages of low cost, large scale commercial production of mobile phones, avoiding the need for expensive and technically specialized limiting device.

In other embodiments, the execution may be desirable to provide the patient with additional buttons or the function button for use. For example, the info button marked "i", may be provided for use by the patient, when he has a question on the current with which the being of the cardiac monitor or message. If you see a message that the patient does not understand the patient presses the i-button and the handset displays information about the current state of the monitor or messages on the display 58. This information is managed by the context, as defined by the current state or status of the system. Information can be presented in text form on the display 58 of the handset or in the form of voice instructions, which are reproduced and reports information in audio form. Another button that may be necessary, is button "911", which calls the emergency number 911 when pressed. Another button, which can be useful in a particular embodiment, is a button "Doctor"that, when pressed, automatically dials the phone number of the physician of the patient.

On figa-8i shows examples of screens displayed on the screen of the cell-phone in the process of applying systems ECG monitoring of the present invention. On figa shown on-screen display when the cardiac monitor and the phone are in the "Process ECG". This mode, which can be initiated by a doctor when you first set up the cardiac monitor the patient. During installation, the doctor places the adhesive contact electrode and the cardiac monitor in different locations on the chest of the patient to search several sites, in which m is can be obtained a good ECG signal. In this embodiment, this is done by removing part of the protective film to open electrode gel without opening the adhesive contact surface, as described in the international patent application IB2007/054879 (Cross et al.) To determine the effectiveness of this provision, the doctor gains a certain combination of keys on the keypad of the mobile phone when the cover 56 is removed from the mobile phone. The key combination puts the cell phone in the execution mode of the process of the ECG. If the ECG monitor and the adhesive contact electrode at the same time not connected to the patient when you activate this mode, is displayed on-screen display figa with instructions to attach a cardiac monitor to the patient. When the cardiac monitor 30 is set in position on the patient, and displays the curve of the patient's ECG in real time as a function of time and amplitude obtained from the patient, as shown in fig.8b. ECG monitor sends four channel data to the monitoring center, three of the main channel of ECG data marked on fig.8b as c1, c2 and c3, and the channel M movement data. In other variants, you can provide other data channels, such as channel control signal. Pressing the right button 64, the doctor may switch the display between all four channels of information. Once your doctor finds desired to the number of positions contact adhesive electrode, and test the ECG monitor 30 and tube mobile telephone 50 in run mode process ECG, he presses the left button 62 to exit run mode process ECG. Then on the screen should display pigs "System OK" button (the system is operating normally). This screen appears when the following conditions are met: ECG monitor 30 communicates with the handset 50; ECG monitor and system software of the handset function properly; quality contact adhesive electrode 20 with the patient's skin is acceptable; and the last self-diagnosis of cardiac monitoring was performed successfully. Therefore, the display on figs indicates that ECG monitor 30 and the adhesive contact 20 is properly attached to the patient and that the ECG monitor and handset 50 work properly. In another embodiment, the you may want to display a message or graphic symbol indicating that the communication with the ECG monitor is satisfactory. Another alternative is that the handset selectively emitted a sound when the connection to the ECG monitor is satisfactory, for example an audio signal, synchronous with the received data of the R-wave In the lower part of the display on figs display text command buttons on the screen above the buttons 62 and 64 when the system is in normal monitoring mode. Left button 62 is used to perform a "voice Record" (Record Voice), and the right button 64 is used to "Call for help" (Call For Help).

On fig.8d shows the display of alerts displayed in the end of the day with a reminder to the patient that a cardiac monitor and handset you want to charge. As described below, this screen warning appears at the specified time every day, if the patient does not begin to charge the cardiac monitor and a telephone handset. On file shows the display that appears when it detects that the battery tube mobile phone low. On fig.8f shows the display that notifies the patient that the battery of the cardiac monitor 30 is low. On Figg shows the display that appears on the screen of the handset when the handset 50 is disconnected from the ECG monitor 30. In a constructed embodiment, the ECG monitor 30 and the mobile phone handset 50 communicate with each other via wireless Bluetooth radio. The patient is advised to keep a mobile phone handset and ECG monitor within six feet (1.8 m) from each other to support Bluetooth wireless technology. If the patient puts up the phone and walk away from it, you will see the display (figd), when the Bluetooth communication will be interrupted. For this reason, the patient is advised to carry a mobile phone handset in the figurative is allare at the waist, to support Bluetooth constantly. On fig.8h shows the display shown on the screen when the ECG monitor 30 detects a bad contact with the patient's skin. The patient is encouraged to press on the edges of the adhesive electrode 20, to more firmly against his skin.

In the case of all the above critical situations, the patient can press the left button 62, to cancel an alarm signal on the screen (fig.8d). Pressing the right button 64 will cause the re-emergence of reminders in an hour. Alarms that have been cancelled will remain on the screen in the form of small images, as shown in Fig until the patient will not perform the required action or will not apply to registered status.

Whenever an alarm message appears on the screen, the handset simultaneously beeps to orally inform the patient that there is a notification. The patient's attention, therefore, is directed to the notification. At the same time or instead of the notification on the display voice instructions stored in the handset can be played through the loudspeaker of the handset. For example, instead of or in addition to the display, which displayed the message "Bad contact" (Poor Contact) and "Push the edge of the adhesive contact (Press down on the edges of the patch), the patient mo is et to hear the voice, which tells me that the contact adhesive between the electrode and the body was bad, and the patient should press on the centre of adhesive contact and by its edges to again properly secure adhesive contact on the body.

The kit of the present invention also includes a charging docking station 90 (Fig.9), which is designed to recharge ECG monitor 30 and tube mobile telephone 50. Figure 9 shows the charging dock is designed options for performing the present invention, which includes a main unit 100, shown in figure 10, with hinged lid 102, which serves to charge the cardiac monitor 30, and the cable 92 with the plug 94 to charge the handset 50. The power cord on these drawings is not visible. The cardiac monitor 30 is placed in a repeating its shape recess in the main unit 100, as shown in figure 10, the electrical contacts 36 are directed downwards. The niche is so that when you install a cardiac monitor in place of the LED 104 is held in the recess 34 of the cardiac monitor. When open the cover 102, as shown in the drawing, the cardiac monitor slightly based on elastomeric charging contacts below. In other versions of the contacts can be a spring-loaded contacts. Cover 102 must be closed in order to charge began, charging will not occur at the open cap is. When the cover is closed, the inner cover tightly presses the cardiac monitor to the charging contacts. This fit is measured charging docking station, which measures the resistance of the adjacent contact. When the lid is closed, as shown by the arrow in figure 10, the electronic circuit and the program in the main unit 100 starts the initialization, and the led starts blinking orange. After initialization is complete, the charging circuit starts to charge lithium-ion battery in the cardiac monitor 30, and the led 104 emits a steady green light. When charging the cardiac monitor starts wireless transfer his archive ECG data in a mobile phone handset 50. The handset immediately transmits ECG data to the monitoring center for analysis, reporting, and conservation. After successfully receiving the archival data was confirmed by the monitoring center, data ECG cardiac monitor erased or removed from the memory to receive new ECG data, when the cardiac monitor is reconnected to the patient.

While the cardiac monitor 30 is charged, the handset 50 also can be charged, as shown in figure 11. The plug 94 of the cable 92 is connected to the handset and charger dock station charging the handset at the same time while charging the cardiac monitor. In other embodiments, the imp is in a mobile phone handset recharged using a standard charger for mobile phone, supplied by the manufacturer of the mobile phone. In the process of charging cell-phone indicator light 96 is illuminated on the handset, indicating that charging is.

After the cardiac monitor 30 recharge, and archival data were transferred to the handset from the charging dock, an electronic circuit and software of the cardiac monitor performs self-diagnostics of the cardiac monitor 30. In diagnostics included such elements of the cardiac monitor as RAM cardiac monitor, check the reading and writing to the flash card cardiac monitor, check the control channel by the movement of the cardiac monitor, checked the wireless radio of cardiac monitoring, as well as analog and digital power supplies of the cardiac monitor. Charger docking station may also generate test signals addressed to the electrode contacts of the cardiac monitor, to check ECG diagram of the cardiac monitor. If charging is not successful not successful transfer of archival data was successful or not any of the self-diagnostic tests, the led will alternately flash orange and green color, indicating the presence of error conditions, and informs the patient that the monitoring center should send a request for service.

On figa and 12b shows the features and components of the ECG monitor, designed the parks in accordance with the principles of the present invention, on figa - functional position, and fig.12b from the position of the equipment. ECG electrodes s1, s2, s3 and RLD adhesive contact 20 is connected to the ECG diagram input stage 202. ECG circuit 202 amplifies and filters the ECG signals received from the patient's body, and takes the weak signal RLD-electrode for the detection of unconnected electrodes. Suitable ECG diagram of the input stage described in the international application IB 2007/054461 (Herleikson), filed November 2, 2007, which is incorporated into the present application. Weak 75 Hz signal is applied to the body with the RLD electrode and can be detected at each electrode s1, s2 and s3. Signal passed at each electrode s1, s2 and s3, is directed to the input of the corresponding differential amplifier with the reference voltage generated by combining the signal electrodes s1, s2 and s3. If the electrode is not attached to the body, 75 Hz signal will be detected in the output signal of the differential amplifier of this electrode. When the electrodes are properly in contact with the patient, the alarm will disappear as a common-mode signal. The signal from the combination signal electrodes comes back on RLD electrode as a feedback signal to balance the voltage in-phase signal and common mode noise. Analog signals from the electrodes s1, s2 and s3 are converted into digital signals by analog-to-digital converters 204 pic what edstam sampling at a frequency of 300 Hz. This sampling frequency is a multiple of 75 Hz signal free of the electrode, allowing you to easily filter 75 Hz signal. The digitized signal electrode is connected to the formatter signal electrodes 206, which generates multivectorial the signal lead s1-s2 and s1-s3. These two signals can be combined to calculate the third vector - s2-s3. Three signal leads are formed in a manner equivalent to the manner in which the formed leads I, II and III of the usual set of ECG electrodes. The signal lead is connected to the analyzer, ECG characteristics 208, which defines the characteristics of the ECG signal, such as ventricular QRS complex, the mean frequency of contractions, the R-R interval and heart rate. Suitable formatter signal electrodes and the analyzer ECG characteristics described in the provisional patent application U.S. 60/954367 (Zhou et al.), filed August 7, 2007. Characteristics of the ECG is connected to the sensor arrhythmia 210, which analyzes the ECG on some characteristics of the signal and the threshold levels determined by the physician of the patient and connected to the sensor fibrillation, as described in detail below. If you find the desired arrhythmia, this event connects to the controller receiving/transmitting 218 together with 90-second ECG strip, starting in 60 seconds prior to the occurrence of the event and ending 30 is of econd after. Time case notes or information about events or on the ECG strip, or both, and can be defined as the time at which the event first appears in the ECG data, the end time of the event, the time when the event was detected, or some other clinically significant timestamp. The strip of ECG and event information that can be sent separately or combined, are packaged and transmitted to the handset via Bluetooth radio 220. This information and all ECG data obtained by the cardiac monitor, subdirections to 200 Hz data rate and stored on the map the flash memory 216 2 GB. Memory 2 GB can accommodate approximately 36 hours of ECG data at a given transmission rate.

The cardiac monitor 30 is a motion sensor M, such as an accelerometer or piezoelectric tape. The motion sensor detects the movement of the monitor connected to the patient, and, consequently, the motor activity of the patient. The traffic signal from the sensor is amplified, digitized analog-to-digital Converter 214 and stored in memory 216. The traffic signal is the fourth channel data sent to the monitoring center along with the ECG signals s1, s2 and RLD, and may be associated with the ECG information to interpret the possible States of pale is the as described in the prior international patent application WO 2007/066270 (Solosko et al.). For example, the pause in the ECG signal, followed by heavy traffic signal may indicate that the patient fainted, lost consciousness.

The cardiac monitor also includes a control circuit power supply 232, which controls the state of the lithium-ion battery 230 and charging it. The power indicator 235 controls the charge on the input and output of the battery and continuously evaluates the condition of the battery, its charge, and its capacity to recharge.

Since in this example, the cardiac monitor 30 is constantly in a sealed condition without external controls, then there is no possibility or need to turn on and off the cardiac monitor manually. Immediately after the cardiac monitor was fully assembled at the factory, it begins to work. However, if a cardiac monitor is not detected after a specified period of time that the contacts are connected with the contacts in the charging dock or adhesive electrode, the power management system of the cardiac monitor translates the cardiac monitor in standby mode. In standby mode, the only scheme that is still running is a detection circuit connected to terminals of the charging dock or adhesive electrode, consuming a small amount of current. When the control system Pete is receiving detects the specified connection cardiac monitoring is switched on and goes in fully working condition. Thus, the cardiac monitor may remain inactive in stock for many weeks or months and be activated actually fully charged during the operation.

In a constructed embodiment, the core of the cardiac monitor is the microcontroller 240, which receives the digitized ECG and traffic signals, performs formatting and analysis of lead signals, and detects arrhythmia described above, and performs the transmission and reception of data via the Bluetooth radio 220. The microcontroller also has a USB port, which is connected with a number of contacts on the rear side of the housing of the cardiac monitor, which provides data binding and programs with a microcontroller and memory devices 216 and 244.

On Fig balance monitoring system of the present invention, including a block diagram of the cell-phone 50 and the channel of communication with the monitoring center 400. The handset 50 is a commercially available mobile phone with Windows Mobile for smartphone. The mobile phone includes an electronic device mobile phone, which receives inputs from the keypad 302 and displays graphical information on the display 58. The handset 50 includes Bluetooth 310, which communicates with one or more monitors 30. In memory 304 2 GB stored programs and data, such as ECG data, transmitted to the handset from the ECG monitor. Power tube mobile phone provides battery 314, controlled and charged by the control circuit power supply 312. Operating system Windows Mobile provides mobile phone directory structure that can be viewed on a personal computer when connecting a mobile phone to a PC with the same cable (USB) 92 used for charging the battery 314. Executable program that controls the operation of the mobile phone as described in the present application is loaded in the mobile phone memory or in the memory 304, or in the internal memory of the mobile phone together with a graphical means for the display of the mobile phone as a template installation. Starting the operating system directory modified in connection with the running program so that when turned on, and download the mobile phone automatically starts to manage the running program and to display the graphical tools developed for monitoring applications. The handset 50 communicates over the cellular network, and then land line with the monitoring center 400 that receives ECG data and status notifications from the ECG monitor, and sends commands and configuration information on the cardiac monitor.

The interaction between the components of the monitoring of the present invention, which are with the patient and which are located in the center of the monitor shown in Fig. The cardiac monitor supports the Bluetooth connection (BT) with the handset 50. The ECG information is sent in the HTTP Protocol to the server 402 in the monitoring center 400. If the transfer occurs during the events accompanying the ECG strip is viewed ECG operator on the system view ECG 404. If the transfer is a daily archive ECG data, they are sent to the system 406 Holter 2010 for sorting and reporting. Event reports, ECG operator, or daily reports on the archive go to a local doctor, the administrator of the patient or administrator responsible for the patient and study. Overall coordination of the monitoring center by one or more administrators of the monitoring center.

Daily transfer of the complete archive of the registration of complete data, with each heart contraction of the patient, allows to diagnose subtle cardiac abnormalities that cannot be detected during normal decoding of the ECG strip. For example, the high limit value of the critical heart rate may be set at a level that significantly exceeds the normal heart rate of the patient. T is thus, a slight increase in heart rate of a patient can be detected as an event, be registered by the sensor arrhythmia of the patient. However, a small increase in heart rate can occur repeatedly within a short period of time or may continue uninterrupted for a long period of time. Such mild changes in heart rhythm can be detected using more complex systems analysis, working full-decoded data, such as the above-mentioned system Holter 2010. The Holter system 2010 can be used to perform analysis of each daily archive of data and preparation of the daily report, which allows to identify such symptomatic profiles of cardiac rhythm. The identification of such subtleties in the daily backup using complex analysis programs in the monitoring center can lead to rapid detection of pathologies in a patient or reset the alarm and critical limits, to better assess the characteristics of heart disease.

The administrator of the patient, for example, the patient's physician may decide in the course of the study to change the settings of arrhythmia that you want to detect. For example, the threshold is detected tachycardia can be reset to 160 beats./min. Such change may be appointed what about the operator ECG monitoring centre, and the new value is sent to the cardiac monitor the patient as configuration changes. The new configuration information is sent by the server 402, taken over the cellular network by the mobile phone handset, and then sent via Bluetooth to the cardiac monitor 30, where is installed in the sensor arrhythmia.

On Fig shows the setup screen, which can be used to configure or reset the thresholds for detection of arrhythmia ECG monitor 30. In this example, limits can be set in the fields with folding menu for ventricular fibrillation, high heart rate normal, low heart rate, low heart rate, asystole, pause at the contraction of the heart and atrial fibrillation. In addition to the detection limits, the user could also set the priority of the alarm, such as an urgent, medium, or low priority. When the operator ECG will install the required threshold values and priorities, the configuration is saved when you click "Save" button at the bottom of the screen. If the study has not started yet, the configuration information is stored on the server 402 in the centre of monitoring and loaded into cardiac monitor when you first connect the cardiac monitor the patient and establishment of its communication channels. When the first connection of the cardiac monitor is monitoring centre checks the configuration information of the cardiac monitor, which then downloaded and installed in the sensor arrhythmia. If the study is already running, the new configuration immediately loaded for installation in cardiac monitoring.

In addition to the seven standard critical parameters arrhythmia, shown in Fig, the user is also given the opportunity to set their own critical parameter that can be configured for a particular patient. Box 160 at the bottom of the configuration screen on Fig contains custom critical parameter, available in the shown configuration. Field 160 is an example of some of the parameters that may be provided for customizing a critical parameter.

The monitoring system of the present invention usually comes in the form of a kit including all components required for monitoring procedures. On Fig shows the screen with which the monitoring center or repair may collect set for ECG monitoring of the present invention from available components ECG monitor 30 and tubes mobile phone 50. Box 172 at the top of the screen shows the list of heart monitors 30 available. The operator selects with the mouse, monitor, highlighting it, then click on "Add selected cardiac monitoring" Add Selected Monitor)to add the selected cardiac monitoring in the set. Similarly, the operator can in order to allocate the mobile device in the field 174 and click "Add selected device (Add Selected Communicator), to add a specific mobile phone handset in the set. Registration number of the collected set appears in field 176 with registration numbers of heart monitors and mobile phones shown below. If the operator is satisfied with the compiled set, he clicks the button "Create set" Create Kit at the bottom of the screen to include the selected components of the concrete set for monitoring.

On Fig shows a screen through which the operator can monitor sets for monitoring when sending and receiving back from the doctors, hospitals and clinics. At the top of the screen there are fields with which the operator can search for a specific set by entering the registration number of the set in field 182, and then clicking "Search" (Search). In a similar way, the operator can select another parameter by which to search for a specific set. For example, the operator can select the location to which he was sent a set, box 184, and then search for all sets, delivered to the specified location. In the large box 186 in the lower part of the screen shows information about sending regarding number of sets, including the date set for the user, the user's location, as well as the registration numbers of the components of the cardiac monitor and the telephone handset on the ora. If the set was received by the repair center, as described below, the set can be entered in the "date received" (Received Date). The tabs at the top of the field 186 are used to mark specific sets as sent or received.

On Fig shows a screen through which the operator can monitor the registration numbers and addresses of Bluetooth heart monitor and connect the selected cardiac monitor with Bluetooth address of the cell-phone. Using the fields at the top of the screen, the operator can enter the registration number to search for specific cardiac monitor. In the large box 196 in the bottom of the screen lists all the heart monitors, available, and their registration numbers and addresses of Bluetooth. New heart monitors can be added to the list by entering their characteristic information in a small field at the bottom of the screen. Fig is a screen through which the operator can search for particular heart monitor registration number, dates of shipment and locations, in which and from which they were sent. This screen also allows you to search for heart monitors that were received back from the user after completion of the study. In a large field 250 in the lower part of the screen lists the search results heart monitors by registration numbers of their set, the date is when they were sent to the location and the dates when the heart monitors were returned from these locations.

On Fig shows a screen through which the operator can search for handsets mobile phones to the registration number, the Bluetooth address or telephone number. In the large box 252 in the lower part of the screen lists the search results handsets mobile phones and their identification numbers, as well as from small fields at the bottom of the screen you can add new handsets.

The screen on Fig similar to the screen on Fig and allows you to search for handsets mobile phones and list them on the delivery location and registration number of the set. This screen also allows you to track tube mobile phones when they return from the user.

When the doctor or nurse will provide the patient with a set for monitoring purposes of the study, one of the first tasks is to determine the provisions on the chest of the patient, which can be attached with adhesive to the contact connected to a cardiac monitor took a strong ECG signal. In addition, it is desirable to find some agreeable to one position on the chest never had to reuse that potentially causes skin irritation with repeated use. On Fig shows the interactive screen, through which the meds the country or the doctor can record information relative to the location of adhesive contact. At the top of the screen displays the data related procedures, such as start date and end date of the procedure. The screen can also register the date on which were updated provisions of adhesive contacts, and who updated the information. In the figure 260 (Fig) people at the bottom of the screen shows the three adhesive contact 264, located on the left side of the chest. Data graphic symbols adhesive contacts can be moved to different positions on the figure, rotate, if necessary, and then commit to write an acceptable position on the chest to attach. Suitable position on the chest of the patient can be found, securing the cardiac monitor in adhesive contact and removing part of the protective film adhesive contact, which closes the location of the electrode, as described in provisional patent application U.S. 60/869009 (Cross et al.), filed on December 7, 2006. Then the adhesive contact can be placed and moved in different positions on the chest with hydrogel electrodes, conductive ECG signals to the cardiac monitor.

Alternatively, as described in the patent application Cross et al., if the protective film has a conductive coating over the locations of the electrodes, adhesive contact, and the cardiac monitor, you can move to find suitable locations, not removing the protective film. Each time when the detection podhodyashaya graphic symbol of adhesive contact 264 re-place the figure 260, to mark the identified position. The screen on Fig can be saved and invoked each time a new adhesive to the contact you want to attach to your nurse or doctor during the study, or the patient picks up a printed copy at home and drawn to it every time you need to replace the adhesive contact. Alternative or additionally, an electronic copy of a human figure can be displayed on the display 58 of the tube mobile phone to instruct the patient when replacing the adhesive contact. Adhesive contacts are typically worn for about three days before it must be replaced.

On Fig shows the screen that is used to record information about the procedure, including the daily alert the patient to take charge of the cardiac monitor and cell-phone. The screen is usually filled, when set for monitoring the patient for the first time, and the patient decides when he or she will be charging the cardiac monitor and handset. Under standard procedure, the patient will wear the cardiac monitor and the phone all day while the patient goes about her daily activities. At the end of the day, when the patient goes to sleep, is the most convenient time for charging the cardiac monitor and mobile phone. The patient will take the charger, side buttons is hydrated cardiac monitoring of charger docking station 90, remove used cardiac monitoring with sticky contact and place it in the charging dock, and then insert just charged cardiac monitoring in adhesive contact. Just before going to bed, the patient will attach the handset to the cord 92 charging dock. Then used a cardiac monitor and mobile phone will be charged during the night. The mobile phone is always left on, and charging docking station preferably left on the bedside table to charge the handset remained in reach for Bluetooth communication with the cardiac monitor on a sticky contact during sleep of the patient. While the patient sleeps, used cardiac monitoring charged his archival data is sent to the mobile phone and the monitoring center, the performing self test of the cardiac monitor, and archive data of the previous day are removed from memory in preparation for the next daily application of cardiac monitor. Preferably, the set included two cardiac monitor, so you can wear one for monitoring, while the other is charging, and its archived data is transmitted to the monitoring center. Typically, the patient goes to bed wearing just charged cardiac monitor, used the cardiac monitor is in the charging dock, pajara is moved during the night and passes their archive ECG data in a mobile phone handset and the monitoring center. If at night, the patient will feel the detected arrhythmia event notification and strip ECG sent to the handset via Bluetooth, and then immediately forwarded to a phone handset in the monitoring center. Both cardiac monitor, and connected to the patient, and the one that is placed in the charging dock, connected via Bluetooth with a mobile phone handset at the moment, and event detected by the cardiac monitor attached to the patient, immediately sent to the monitoring center, without waiting for the transfer of archival data or on the basis of high-priority interrupt, or on the basis of a temporary seal.

If the patient forgets to place the cardiac monitor in the charging dock to its archival data could be uploaded to the monitoring center, or for any other reason will not be able to do this, the handset will prompt the patient to perform this action, as shown in fig.8d. If the patient rejects the request or ignore the request and continue to wear the cardiac monitor, there may come a time when the memory of the cardiac monitor will be completely filled with the registered ECG data. In this situation, the cardiac monitor will begin to work as a loopback recorder. Recent data ECG signal will be stored in memory, and the oldest stored ECG data will be the jammed recording and lost.

When the patient gives the doctor or nurse schedule the time that the patient expects to start a daily routine recharge time for each day is recorded on the screen Fig. Then the patient may be given a printed copy of the screen that he can take home. In addition, the screen is sent to the monitoring center, and reminders about charging is sent in the form of configuration information in the cardiac monitor the patient or the phone. Every day at the appointed time reminding message about charging appears on the screen 58 handset (see fig.8d) and is accompanied by an audible tone or voice prompt, which attracts the patient's attention to the memo. The schedule can be changed easily by placing other information on the configuration of the reminders in the cardiac monitor or handset.

On Fig shows the screen, which required the reporting physician can be registered with the monitoring center. The screen above shows the date of commencement and completion of the procedure. Section "screen delivery reports deliver) indicates the time when the daily message is sent to the doctor, and the mode in which it will be sent. Typically, the physician receives a every day report on the events of the previous day and the analysis of the ECG information registered within 24 hours of the previous day, daily archive data is ECG. This example also indicates the time and date when section delivery report has been updated.

Reports and information of the patient can be placed on the server 402 in monitoring centre for access to certain accounts. The account can have a separate physician, hospital or clinic. Patient information must be password protected for security of individual patient data. On Fig shows the screen with which the monitoring center can monitor the activity of a specific account. At the top of the screen provides information about the condition, as well as information about the account password and using it. A large number of unsuccessful attempts to access the password may be an indication that someone is trying to gain unauthorized access to account information that you want to investigate. The activity log in with account also being tracked on this screen. The list box 262 in the bottom of the screen indicates individual session, when a separate account has been logged on to the server and exit from the server, including the duration of the session.

On Fig presents a screen that shows the log patient communication with the monitoring center. The search field at the top allows the operator to seek information about the patient on site, doctor or patient. The search results, including patients, their doctors, their is rocedure and date procedures displayed in field 272. Details for the selected patient are displayed in field 274. The last communication session between the patient and the monitoring center is registered in the upper part of the field, and previous communication sessions are listed in the lower part of the field.

On Fig shows the screen view ECG, suitable for obtaining and analyzing information about the event, obtained from the centre for monitoring the cardiac monitor of the present invention. In this embodiment, the screen viewer ECG has three main sections: the notification Window 282, which specifies information about a specific procedure or study, and lists the notifications received from patient to patient; the event Window 284, which indicates the information obtained during the event; and a ECG viewer 286, in which the data transmitted by the cardiac monitor all channels can be analyzed in detail. On Fig Window notifications and events is not extended, and the viewer ECG expanded. In this embodiment, the ECG monitor 30 passes five data channels, and the handset transmits a voice channel that is written to the phone. The data represent three of the ECG signal, in this example, s1, s2 and s3, the signal RLD ("rld"), and channel movement ("vp"). The differential signal leads s1-s2, s2-s3 and s1-s3 can be obtained on the basis of the signal is in the ECG of this example. The signal RLD can be used for further processing and purification of lead signals, and to identify interference. Controls on the left of each strip on the display allow the operator to adjust the calibration, and other parameters of the bands on the display. In the bands display of this example, it is noticeable that the signal is strong motion was recorded during significant ECG signals of the channels s1-s2 and s1-s3. Controls audio messages 288 at the bottom of the display, reproduce transferred from the patient's recorded voice message to the operator viewer ECG.

On Fig shows the screen view ECG with Fig with advanced notification Window 282 and the event Window 284. In a constructed embodiment, the cardiac monitor 30 sends a notification whenever the status of the cardiac monitor, with notification data, as those notifications that are generated when the status of the cell-phone are sent to the monitoring center by the mobile phone handset. For example, when the cardiac monitor detects that it is connected to the patient and receives the ECG signals from the patient, the monitoring center sends a status message. When the cardiac monitor detects loose electrode, the monitoring center sends a status message. When desacralize the electrode is again attached, in the monitoring center sends a status message. When the cardiac monitor is cut off from the adhesive contact, the monitoring center sends a status message. Thus, a continuous stream of status messages allows the monitoring center to evaluate the use of cardiac monitor the patient, the operator at the monitoring center can intervene in the situation, by making a call to the mobile phone of the patient, if the message flow indicates that the patient has difficulty or the patient missed something. In table 1 below lists some of the common messages that can be sent in the process of applying the monitoring system.

Table 1
NoticeType
The cardiac monitor the patient works fineState
Unconnected electrodeState
Unconnected electrode fixedState
The cardiac monitor is removed from the patientState
The cardiac monitor is turned off State
Battery low (cardiac monitor)State
Low battery (handset)State
The run mode, ECGState
Lost BluetoothState
Bluetooth restoredState
Lost communication with the mobile phoneState
Communication with the mobile phone restoredState
Successful self testState
Failed self testAnxiety
The cardiac monitor is placed in the charging dockState
The cardiac monitor is removed from the charging dockState
Charging monitor startedState
Charging monitor completedState is s
Charging the cardiac monitor failureAnxiety
Charging mobile phone startedState
Mobile phone charging completedState
Mobile phone charging failureAnxiety
Error charging dockAnxiety
The transfer archive ECG startedState
The transfer archive ECG completedState
Information about the event + stripe ECG sentAlarm: priority = high, medium, low
Voice message + stripe ECG sentAlarm: priority = high, medium, low

Various notifications can be processed in different ways. For example, the interruption of the connection of Bluetooth may be a usual event. The patient can put the handset and go to perform some task that leads to the loss of Bluetooth connection, when the cardiac monitor is out of DOS is haemost tube mobile phone. A few minutes later, the patient returns to the tube mobile phone, picks it up and cleans carrying case, bag, or pocket, while Bluetooth is resumed when the cardiac monitor and the handset returned to the zone of the Bluetooth signal each other. Under such circumstances, it may be desirable to delay the notification of the loss of Bluetooth connectivity in five or ten minutes to give time to resume communication before sending the notification. Alternative notification of loss of communication can be sent immediately as a status message, and if the notification that the connection has been restored, comes within a short period of time thereafter, notice is cancelled or automatically marked as resolved. If notice of the resolution does not come within five or ten minutes, or for some other specified period of time, the priority notice in the monitoring center increases, in order to draw the attention of the operator. Similarly notifications unconnected electrodes can be delayed or subjected to higher priority that the patient was able to notice and correct the situation without sending the notice or a response is received from the monitoring center.

It should be understood that various status notifications can is to come from various sources. Notice that the Bluetooth connection was lost, must come from the cell-phone as a cardiac monitor is out of communication with the handset at the moment and can't send the message. Similarly, the notification that the communication with the mobile phone was lost, appears in the centre monitoring usually when monitoring centre tries to send a message to a mobile phone and discovers that it is impossible.

In the example on Fig all notices received from the patient are listed in the Box to the notification 282. Normal status notifications appear in the standard text and in chronological order of receipt. Alarm events with a higher priority are displayed at the top of the list of notifications and highlighted to indicate urgency, for example yellow highlighting for the critical events of the middle priority, and red highlighting for critical events of high priority. In a preferred embodiment, the events of ventricular fibrillation and asystole have the highest priority, notification pause heart rate and heart rate following priority notification unconnected electrodes and poor contact of the electrodes below by priority and other state changes and technical alarms, such as low battery is Atari and loss of connectivity, have the lowest priority. Because notifications reviewed by the operator ECG monitoring centre, they can be handled the proper way, and then deleted from the displayed list. In the second box 283 in the notification Window 282 are designated for input, where the operator may enter a judgment on notice and provide comments on the conclusion. The notification window, thus, provides a list of tasks that the operator can use to consider and process notifications received from the cardiac monitor the patient, in order of priority and effective manner. In the described embodiment, the notification received from one patient can be treated by several specialists at the same time, however, when the technician selects a specific notification for analysis and conclusions, other viewer ECG blocked from selection notice that only one operator can work on the report on notice at any time. This is to prevent duplicate processing of a single notification and provides flexibility in many viewers ECG in a large monitoring center.

Status notifications can also be shown on a separate screen, as shown on-screen display Fig. As shown in this example, the notification with the standing regime change low priority are listed under the event a higher priority "Critically low heart rate" at the top of the list. Notifications that were considered by the operator, there are control mark in the box to the left of the notification. The fields at the top of the screen is used to search for notification of specific characteristics, such as event Notifications, or notifications received during the selected period of time.

Upon receipt of the event notification including the voice recording of the patient, the event notification is accompanied by a 90-second ECG strip, which began to be recorded for sixty seconds before the time of the event and continued to enroll within thirty seconds after him. Event notifications appear in the event Window 284. The identity of the event is displayed in the first field 285, and the ECG strip that is submitted with the notification of the event appears in box 287. The operator of the ECG, thus, can quickly review the ECG signal, a synchronous event. If you want a more detailed analysis, the ECG strip may be considered in the advanced window, review the ECG at the bottom of the window of the browser, as shown in Fig.

On Fig shows the characteristic options for performing the present invention, which represents an increase box 290 ECG. The operator ECG can click the right mouse button on the box 292 ECG strip, when it is necessary to consider the form of teeth ECG in more detail. A list of options appears, and the operator is iberet "magnifier", when this occurs, all the magnification window 290. The Central region of the ECG strip, in which there is a magnification window 290, shown in enlarged scale in box 290. The settings option allows the user to determine the degree of magnification (e.g., 2, 5, 10) within the magnification window 290. The user can move the magnification window on the window 292 with ECG strip to increase any plot shows the ECG strip.

On Fig-37 shows the stages of the method by which can be performed some actions, accompanying the application of the system ECG-monitoring of the present invention. On Fig shows the sequence of steps performed during registration of the patient to the procedure of ECG monitoring. At step 321, the doctor patient registers the patient in the monitoring center. Patient information is transmitted to the monitoring center, the monitoring center preparing to receive notifications from the set that is used by the patient. The doctor may already have a set that can be used by the patient. Otherwise, the monitoring center sends the doctor set for use by the patient. The monitoring center links set used by the patient, with the patient, which registered doctor. At step 322, the monitoring center sets up requirements for reports required by the physician, using the screen, the AK is shown in Fig. At step 323 configure the types of signals about the arrhythmia, which will be tracked using this screen, as shown in Fig and 16, with the critical limits set, as shown on these screens. At step 324, the monitoring center configures schedule reminders regarding the time in which the patient will be asked to charge the phone and the cardiac monitor, as shown in Fig. If the doctor has completed the placement of adhesive contacts on the circuit, as shown in Fig, the diagram in step 325 is sent to the monitoring center for use by operators monitoring center in the event of patient care in the placement of adhesive contact. In other cases, the layout of adhesive contacts can be sent to the monitoring center at a later date. It is obvious that most or all information presented on the stages on Fig, may be provided by the physician performing the registration and configuration remotely in the doctor's office, without direct contact with the monitoring center. Thus, the setup screens can be made available for account monitoring centre as a network-accessible application. After entering the information in the remote terminal, it becomes available in the monitoring center, which can handle and register the patient without personal contact with the doctor.

The piano is g shows the sequence of steps performed during the initial registration of the patient in the monitoring system of the present invention. At step 331, the doctor or nurse may include a mobile phone handset 50 and transferred telephone handset mode ECG. The cardiac monitor 30 is inserted into adhesive contact 20 at step 332 and remove the perforated center of the protective film with the adhesive contact to open gel electrodes. If provisions for attaching adhesive contact were not pre-planned on the chest of the patient, the physician moves and/or rotates the adhesive contact and the cardiac monitor on the chest of the patient, as described above, to determine one or more appropriate positions and orientations for attaching adhesive contact, which can be obtained a clear ECG signal, as indicated by the display of the current ECG. As soon as a suitable position on the chest is found, at step 333 is filled arrangement of adhesive contacts with the aim of recording provisions, then the scheme is sent to the monitoring center, and a copy given to the patient at step 325 Fig. The protective sheath is completely removed from the adhesive contact 20 to open an adhesive surface, and then at step 334 adhesive contact and attach cardiac monitor in one of the defined positions on the chest of the patient. At step 335 channels of ECG data begin to flow and it will appear on the display 58 handset, confirming the communication via Bluetooth between the cardiac monitor 30 and handset 50. The doctor may otherwise move the tee a mobile phone handset in normal operation, clicking the left button "Exit" button, shown in fig.8b, and call center monitoring step 336, to verify the second communication channel between the handset and the monitoring center. Alternative monitoring software cell-phone can be programmed to perform the connection automatically. The operator at the monitoring center can check the complete communication channel by sending, for example, the cardiac monitor to transmit the ECG strip in the centre of monitoring and confirming its receipt in the viewer ECG monitoring centre. Connection to Central monitoring may indicate the need for more changes in the position of the cardiac monitor and adhesive contact. When the handset 50 registers the first message from the cardiac monitor 30 to the monitoring center, the monitoring center is responsible through data configuration procedure on a cardiac monitor 30. Configuration data and the corresponding critical values of the arrhythmia are installed in the cardiac monitor at step 337, then the cardiac monitor may continue the investigation.

When the time comes to replace heart monitors and used to charge the cardiac monitor, can be used the sequence of steps shown Fig. At step 341, the patient removes cardiotonic the R 30 with the adhesive 20. If the adhesive contact 20 needs to be replaced, it is removed from the breast and attach a new adhesive contact to another area of the skin to avoid irritation, using the layout of adhesive contacts (Fig). Cardiac monitoring, recharge, which in the previous day and is still in the charging dock 90 are then removed from the docking station and set in adhesive contact at step 342. At step 343 used the cardiac monitor is placed in the charging dock and close the lid 102, after which the receiver of the mobile phone attached to the charger cord 92 at step 344. Preferably this procedure is performed during sleep, when this charger dock is located next to the patient bed, the patient could go to sleep and stay in the zone Bluetooth rechargeable handset 50. Morning when the patient gets out of bed, the patient disconnects charged the phone from the charger cord and place it in the carrying case on your waist at step 345.

It should be understood that wireless communication system, the Bluetooth communication between the cardiac monitor 30 and handset 50, and the connection between the handset and the cellular tower may be disturbed due to various reasons. The radius of the Bluetooth communication is usually about a foot (0.3 m), and it is generally recommended that the patient was holding a mobile phone handset is within six feet about yourself, to support this relationship. If the patient will leave the handset and will take some time, this line of communication will be interrupted. Similarly, the patient with cardiac monitor and handset may leave the coverage area transceiver station, mobile communication, and the communication with the mobile phone will be lost. As another example, if the patient is going to travel by plane, instructions aviation require that the handset was turned off prior to takeoff of the aircraft and was in the off state until the aircraft has landed. Thus, communication with a mobile phone can obviously be unavailable for several hours.

Violation Bluetooth has no influence on the cardiac monitor 30. Cardiac monitoring will continue to receive ECG signals from the patient and will continue to analyze information about the work of the heart and save the data in the memory 216, even if Bluetooth is not active. If it finds a case of arrhythmia, it will be impossible to transmit event data or other status message on the handset 50, while Bluetooth connectivity is restored. Usually Pets to timeout when outside the zone has expired before the handset will send a message about the status of the Bluetooth radio in the monitoring center, h is usually used to allow you to reconnect the patient to send messages about the status change. When restoring a Bluetooth communication event data and corresponding ECG strip, and all other pending notifications are immediately sent to the handset to register to the monitoring center. Preferably Bluetooth radio operates in the mode of "analysis" (sniff), the mode with low power consumption, in which the synchronization between transmitter and receiver Bluetooth can be maintained for short intervals, and then quickly resumed. When the cardiac monitor must send a message that the Bluetooth transmitter is returned to a fully active state to transmit the message. Bluetooth operates in duplex mode to either the cardiac monitor or handset could start sending data to another component. Cardiac monitoring continues analyze cell-phone until the link is broken, so that when the handset will return to the area, with pending messages, such as event data and status can be sent to the handset and to the monitoring center.

If Bluetooth is active, but violated the service of mobile phone, the connection between the cardiac monitor 30 and handset 50 will be maintained until the handset will not turn on. Event message and the state will continue to come from the cardiac monitor on connections and Bluetooth and received mobile phone. However, messages will not be sent to the monitoring center, and will be stored in memory on the mobile phone until the service mobile phone will not be restored. When service will be restored, messages stored in the mobile phone will immediately be sent to the monitoring center. This is due to the fact that the card is flash memory on a mobile phone has the same or greater capacity as the memory in the monitor, in this example, 2 GB. This means that if the service mobile phone is interrupted during the night, when the historical data of the last day are downloaded from the cardiac monitor, the file transmission via Bluetooth from a mobile phone can continue, even if the service mobile phone will stop. The archive will continue to be transmitted from the cardiac monitor on the handset, even if the service mobile phone will stop, because the card flash memory 304 of the mobile phone has sufficient capacity to save the entire archive in a constructed embodiment can accommodate up to several days full of archived data. When the mobile phone is restored, the mobile phone automatically continues to send archive data to the monitoring center.

In the analysis of ECG and event data, it is important to register the time of the event and forms the teeth, that could be mapped all obtained from the patient information to make an accurate assessment of the condition of the patient. This means that the information must have a timestamp with time of occurrence information and that information must be associated with a common time base. Patient data can get a temporary tag at the time of their admission to the monitoring center and there can be associated with a common time base, however, as just mentioned, the connection over the wireless connection can be interrupted, holding, thus, the flow of data to the monitoring center and leading to erroneous time stamp. Each cardiac monitor has its own time base and built-in clock that can be used to assign a timestamp to the data before they are stored in the memory of the cardiac monitor or sent to the monitoring center. The monitoring center, thus, would have a common time base for the data received from the cardiac monitor. However, in the set according to a preferred variant of execution are two of the cardiac monitor, which in turn are replaced every day, with each cardiac monitor has its own clock. Accordingly, the clocks of two heart monitors can be synchronized before sending the set to the patient. But over a long period of time h, the points may deviate, this watch two different heart monitors may vary with different speed for an extended period of time, which may lead to differences in time base between the two clocks. In a preferred embodiment, the above problems are solved not by regulating hours of cardiac monitoring, and by correlating the patient data with a time base of the cellular network. The handset periodically sends its temporary base on the basis of the data of the cellular network at the cardiac monitor(s). When the time mobile phone arrives on the cardiac monitor, cardiac monitor saves time mobile phone and the current time of the cardiac monitor as part of the patient data. When the monitoring center receives the data with the specified timestamp information, he may correlate patient data with a time base based on the data from the cellular network. The monitoring center having access to a cellular network and its temporary basis, may correlate with the patient and their timestamps time-based cellular network with its own time base, if necessary. In this way the data generated by several heart monitors used by the patient are correlated with total and reliable time base.

As described above, in an embodiment of the present invention to the patient to control the tube mobile of telefonprofilen only two buttons 62 and 64, as shown in Fig.6. As previously mentioned, the default function of these buttons is "help" (Call for Help) and "voice Record" (Record Voice), as indicated by the signatures touch keys on the screen 58 above the buttons. On Fig presents an example of how the button "help" can be used in an embodiment of the present invention. The patient usually receives an instruction to use the Call button help whenever the patient has difficulty or question on the monitoring system or is in a condition requiring medical emergencies. In any of these situations, the patient presses the button 64 Call help on the handset 50, and the handset is connected to the monitoring center stage 352 by a single number that it can cause in this embodiment. As soon as the call is made, the cardiac monitor 30 at step 354 starts sending the ECG strip to the monitoring center over a 90-second period beginning before the time of the request and continued for some time after that. Health worker monitoring centre is responsible for the voice call at step 356 and starts the conversation with the patient. Until the operator says to the patient, it can be considered parallel strip ECG to ECG data could be analyzed, if patientswith with the problem of a medical nature. In a constructed embodiment of the present invention, the operator and the patient can participate in a voice communication in the time until the data strips of ECG arrive at the monitoring center, there is no need to terminate the voice call so that you can send ECG data. If the patient will have a question about the monitoring system, the question will be asked of the operator, as indicated at step 358. The operator will provide the required information or guidance, so that the patient can continue to effectively use the monitoring system. If the call is done with the patient in a condition that requires immediate medical care, the operator can make a call 911 for help or if possible in the current circumstances, to inform the physician of the patient about the situation. This telephone service using monitoring center should be available to patients around the clock and every day.

On Fig some examples of using buttons 62 "voice Recording" handset 50. When the patient feels a heart symptom, the patient will use the monitoring system as a recorder of events, as determined by his physician, pressing the button voice Recording at step 362. When the button is clicked, the patient listens to instructions from the handset, he will be prompted to record a message, if t is pipe mobile phone has similar functionality built in. In other embodiments of the statement of account can be provided in the printed user guide that comes with a set of monitoring. If the message has a fixed maximum length, then the patient will be given instructions not to exceed the specified time or to make the second message, if the recording time is longer. This information can be provided in graphical or audio form. As the patient speaks into the microphone of the mobile phone, the voice of the patient is recorded by the mobile phone at step 366. Button voice Recording also sends commands to the cardiac monitor 30 to submit a 90-second ECG strip, covering the time of the voice message at step 364. Recorded voice message and the accompanying ECG strip is sent from the handset to the monitoring center where the operator ECG can listen to the recorded message of the patient and at the same time to analyze the data strip ECG the ECG viewer.

On Fig presents an example of how the monitoring centre can respond to the problem that is reported by the monitoring system. At step 372, the monitoring center receives the status notification from the cardiac monitor the patient. As mentioned above, in a preferred embodiment of the cardiac monitor sends the message is their status in the monitoring center of each status change of the cardiac monitor. The status notification may consist in the fact that the electrode is not attached to the patient's skin or that the cardiac monitor was placed in the charging dock, for example. In the case of these two examples, the handset notifies the patient that the error condition requires his attention, the patient may solve the problem without the intervention of the monitoring center. When the cardiac monitor 30 detects unconnected electrode on the handset 50 is sent to the message, and the display 58 mobile phone graphic symbol, as shown in accordance with fig.8h informing the patient about the problem and show how to solve the problem. The display is accompanied by a sound or a sound signal from a handset that attracts the patient's attention to the displayed message, and may also be accompanied by a voice prompt that instructs the patient to take the necessary action. If the patient is unsure what to do, the patient can press the "i" on the handset options run with this button while the voice message corresponding to a situation with a description of the problem, shown graphically, and its solution. However, it is possible that the patient may not notice the message data, and the situation will remain unresolved, for example, by the tea if the patient sleeps. In such cases, the monitoring center can be expected for some period of time after receipt of patient status notification (DSN) before solving the problem. If this time period has passed without resolution of the problem, the viewer ECG may raise the priority of the notification to a higher level, resulting in the monitoring center will take the desired action. The operator at the monitoring center will call the patient on the mobile phone at step 374. When a patient will respond on a mobile phone, the operator and the patient will discuss the problem, the operator can instruct the patient to solve problems on stage 376. In this example, the solution may result, for example, replacement adhesive contact 20 new adhesive contact.

In the second example, the patient may place the cardiac monitor 30 in the charging docking station 90 for charging, but forget to close the lid 102, which is necessary for the beginning of the charging process in this example. By measuring the contact resistance of the connection charging dock or cardiac monitor detects that the cover has not been closed, and the cardiac monitor was not pressed against the elastomeric contacts the charging dock. In other embodiments, the run switch is in the charging dock can detect that the cover has not been closed, with the cardiac monitor in the monitoring centre bude is sent a status message. The status notification, sent from the cardiac monitor, arrives in the control centre at step 372, notifying the monitoring center that the cardiac monitor was removed from adhesive contact and/or placed in the charging dock, but the charging process is not started. The patient on the spot informed about the problem, either by lack of green light while charging in the charging dock, either by display or flashing led's 104 charging dock warning light, for example alternately flashing orange and green. Graphics and sound or voice request can also be displayed and proceed from cell-phone 50, informing the patient about the problem. However, if the patient does not seek to draw attention to the problem after a certain period of time, the notification received by the monitoring center, gets a higher priority in the viewer ECG, the monitoring center can take appropriate action. The operator at the monitoring center will call the patient to the mobile phone 50 and discusses the situation with the patient at step 374. Then the patient and the monitoring center resolve the situation through a voice call 376, when the patient closes the lid 102 of the charging dock and starts charging the monitor.

In the case of other notifications received center is monitoring, patient participation is not required or feasible. For example, if at the end of charging and transfer archive of self-diagnosis performed by the cardiac monitor will show the error status in the cardiac monitor, the led 104 on the charging docking station 90 will flash alternately green and orange, informing the patient that he contacted the monitoring center using the button 64 "help" on the handset. The result of the self-test will also require sending the cardiac monitor 30 notification of the result of self-diagnosis in the monitoring center, and if the error condition will not prevent the transmission of the notification, the monitoring centre will be informed about the problem when you receive a notification. The operator at the monitoring center will see the notification and, if the state is reported to require his attention, the operator can subsequently call the mobile phone 50 of the patient and instruct the patient to take the appropriate action. Another cardiac monitor replacement can be sent to the patient with a special courier to replace cardiac monitoring with an error, for example. In this case, the patient will be instructed to start using the replacement cardiac monitoring and send the cardiac monitoring with an error status back to the monitoring center. In other embodiments, the patient is provided Aut not only a new cardiac monitor, but a new mobile phone handset connected via Bluetooth. Another alternative is to download data over a Bluetooth connection on a cardiac monitor and a telephone handset from the monitoring center.

Procedure or the study conducted with the use of a monitoring system of the present invention, generally last for an average period of twenty-one to thirty days. At the end of the study, the patient returns the components of the kit for re-use by other patients. The patient may include a set of your doctor at the next visit to the office, but preferably the set comes with a container for transportation, which pre-specified address and paid for delivery by mail, or packaging to return the kit, once the study is completed. The set can be returned to the monitoring center, where it will prepare for the next patient, but preferably set to return to the repair center that specializes in the inspection and training sets for the following patients. On Fig shows some of the procedures performed by such repair centre in preparing the set for re-use. At step 380, the set of receive repairs from a mail courier or transport service. The components of the kit extract, disinfect at step 382 to accept prevent the possibility of the CSO contact with infectious agents and produce an account, to determine that all components of the kit were returned. Database screens, such as shown in Fig, 20 and 22, can be used to register the receipt of the returned set, and its heart monitors and cell-phone. If any component is missing, the patient or physician contact to the missing item could be returned to the repair center. At step 384, charge a cardiac monitor and cell phone batteries and at step 386 battery heart monitors and cell-phone check, to ensure that they can continue to charge to the required level over the next study. At step 388, any patient data still present in the memory 216 and 304 heart monitors and tubes mobile phone, removed to protect the privacy of the patient. At step 390 components subjected to self-diagnosis results check. At step 392 the components of the kit and examine to confirm their operability per technical requirements. At step 394 update software charger docking station 90, the tube mobile telephone 50 and the heart monitor 30 when the updates become available. As previously mentioned in relation to fig.12b, in a preferred embodiment of the heart monitor 30 have a USB port available through the contacts on the back of the monitor Cabinet. New software can be loaded into the cardiac monitor using the USB connector. Also, it may be desirable to re-capture the image storage device for storing data of these devices every time, to ensure that for each patient, installed new software. The components of the kit can be re-enabled in the set at step 396, then the set sent to the warehouse for subsequent delivery to a new patient. In a preferred embodiment, the kit includes two cardiac monitor 30, a mobile phone handset 50 with a cover 56, charger docking station 90 with a cord 92 for charging a mobile phone and the power cord, carrying case for cell-phone, a number of adhesive contacts 20 and user manual with instructions for the patient. Preferably the kit is delivered to the patient in a box or package, which is suitable to send the set back to the repair center, the monitoring center or doctor in the same box or package in which the set was delivered to the patient. Alternatively, as indicated at step 398, the individual components of the kit can be placed into storage for future inclusion in the set, as described in relation to Fig.

Other options and features of the present invention will be apparent to experts, kV is limitirovany in the art. For example, commercially available mobile phones with integrated GPS (Global satellite navigation system)that identify the geographic location of mobile phones. The use of such a mobile phone in the implementation of the present invention could tell the location of the cell-phone in the monitoring center, allowing the monitoring center to direct medical care in the exact location of the patient in the event of life-threatening arrhythmias or other conditions requiring urgent care. In alternative positioning of the patient can apply the methods of cell triangulation. For example, if the monitoring center receives the event notification and the ECG strip, indicating the occurrence of serious cardiac events, the operator at the monitoring center immediately makes a call on a mobile phone handset of the patient to verify, whether the patient needs medical care. However, cardiac event may cause the patient to lose consciousness and be unable to respond to the request from the monitoring center. The control software of the handset of the mobile phone is programmed to respond to a query from the monitoring center after a certain number of rings, thus SV the relationship between the monitoring center and the mobile phone of the patient will be installed, even if the patient does not respond on a mobile phone. In the United States the operator in the control centre can then call the local rescue service 911, which can accurately determine the location of the patient on the connection between the monitoring center and the mobile phone handset of the patient. Medical assistance can be immediately sent to the set location of a sick patient.

1. The cardiac monitoring system for ambulatory patients, including ECG monitor that contains:
non-conductive waterproof case;
the battery located in the housing;
a processor for processing ECG signals located in the housing and having an input for receiving ECG signals from the patient;
memory arranged in the housing, for storing the processed data of ECG signals;
a wireless transceiver located in the housing and coupled to the processor for processing ECG signals and wireless information transmission of ECG signals to the receiver;
a user interface located on the outside of the housing and electrically connected to one or more components in the housing, and the user interface contains only the set of electrical contacts, and
the power scheme that is configured to detect the Oia connection contacts ECG monitor with external charger docking station and detection what ECG monitor electrically connected to receive ECG signals of the patient, and
when this control circuit Board in addition made with the ability to switch ECG monitor mode low energy consumption, when the ECG monitor is not connected for receiving ECG signals of the patient and is not connected to charge the battery, and
advanced power management provides switching ECG monitor mode high energy consumption in response to detection of connection for charging.

2. The cardiac monitoring system according to claim 1, in which the ECG monitor is always powered, at least up mode low power, if the battery is charged.

3. The cardiac monitoring system according to claim 2, in which the ECG monitor is powered up mode, high energy, which is higher than the low energy consumption during operation of the wireless transceiver and cardiac monitoring of the patient.

4. The cardiac monitoring system according to claim 3, in which the ECG monitor is additionally configured to perform a self-test operating mode, ECG monitor, and ECG monitor powered up state of high energy during the self-test.

5. The cardiac monitoring system according to claim 1, in which a processor for processing the ECG signal is additionally configured to determine that the ECG monitor, the R is electrically connected to receive ECG signals of the patient.

6. The cardiac monitoring system according to claim 2, in which the docking station includes electrical contacts for supplying charging current
when the contacts of the charging circuit of the battery ECG monitor connected to the electrical contacts of the docking station while charging the rechargeable battery.



 

Same patents:

FIELD: medicine.

SUBSTANCE: invention refers to event correlation systems. A health care facility network contains a number of electronically stored patient records comprising electronically searchable data, a base event list consisting of a number of base event definitions, a related event list consisting of a number of related event definitions that can be correlated with the base events, and a correlation processor that uses the base event definition and at least one related event definition to relate the events and scans the patient records to search a pre-assigned correlation.

EFFECT: enhancing the collection and correlation of the events providing better follow-up and clinical results in a patient managed by a doctor.

21 cl, 5 dwg

FIELD: chemistry.

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12 dwg, 1 ex

FIELD: chemistry.

SUBSTANCE: invention relates to computer method, which uses biochemical databases in design of novel protein compounds. Design is performed by operator by means of specially written software PROTCOM basing on application of database of protein pentafragments. Design process consists in specifying and introduction into PROTCOM software of initial sequence of five amino acids (specified initial pentafragment) and written in binary system ten-digit number, which describes secondary structure of specified initial pentafragment. Search of said sequence is performed in database fold with the number, corresponding to specified ten-digit number. Search is performed until specified initial pentafragment is found in database. After its finding, said pentafragment is considered to be the first of possible number N of pentafragments of designed primary protein structure, and it, together with ten-digit number of fold, describing its secondary structure, is recorded into the programme working file. After that, secondary structures of each following number of (N-1) pentafragments are specified by introduction of the same or changed ten-digit number, describing secondary structure of the previous pentafragment into the programme, and search is performed in database of pentafragments, containing four amino acids of each of (N-1) pentafragments, recorded in working file, and one new one. When such pentafragments are found, one of new amino acids is selected and linked to four last amino acids of the previous pentafragment, new amino acid and ten-digit number of fold, describing secondary structure of each found pentafragment are recorded into working file. Obtained in working file sequence of amino acids, with corresponding description of its secondary structure, is considered to be designed primary structure of protein.

EFFECT: claimed method of designing primary structure of protein considerably simplifies and accelerates the task of designing proteins with specified secondary structure.

5 dwg, 21 tbl, 2 ex

FIELD: chemistry.

SUBSTANCE: invention relates to biotechnology, specifically a method of producing artificial oligonucleotides that are potentially capable of forming non-canonical structures that stable in physiological conditions and conditions close to physiological, said structures being imperfect G-quadruplexes (lmGQ) which include one nucleotide substitution in the G4 plane in the G-quadruplexes (GQ). Said method includes using an algorithm describing nucleotide sequences in form of a defined set of formulae for further synthesis of selected oligonucleotides.

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4 dwg, 2 tbl, 2 ex

FIELD: information technology.

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11 cl, 3 dwg

FIELD: information technology.

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8 cl, 7 dwg

FIELD: physics.

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5 cl, 1 dwg

FIELD: information technology.

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60 cl, 19 dwg

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine. In realisation of methods implanted gastric restricting device is implanted into patient's body. Data, containing information about values of parameter, perceived inside the body, are collected for a time period. In the first version of method realisation determined are values of perceived parameter, which exceed the first threshold, are below the first threshold or below the second threshold in such a way that pulse is determined by time between values, which exceed the first threshold and values, which are below the first threshold or below the second threshold. In the second version of the method additional values of perceived parameter, accompanied by decreasing values, are determined. In the third version of the method areas under the curve of pressure dependence on time are determined, compared and the result of comparison is correlated with the state. In the fourth version of the method values of perceived pressure are formed for demonstration on display or further analysis. In the fifth version of the method average value of pressure for time X within the specified time period is calculated on the basis of values of perceived pressure within the window of averaging in specified period of time.

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32 cl, 77 dwg

FIELD: medicine.

SUBSTANCE: group of inventions relates to medical equipment. Wireless system of cardiac control contains ECG monitor and mobile phone. ECG monitor contains transceiver for wireless transmission of ECG signal data. ECG monitor contains connected with transceiver unit of notification about status for transmission of notification in case of change of ECG monitor status. Mobile phone contains electronics, transceiver for wireless reception of ECG signal data or notifications from ECG monitor and controller for transmission of ECG signal data into the control centre by electronics via mobile connection net. Controller can respond to notification from ECG monitor by communicating notification to patient by means of mobile phone or transmission of notification into the control centre. Notification is communicated to patient by means of mobile phone display, tone signal or verbal prompt, formed by mobile phone. Controller can delay transmission of specified notification into the control centre to give time for reception of notification about status of disorder elimination. When patient is informed about change in status patient is given possibility to answer immediately or to delay respond to notification.

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6 cl, 38 dwg, 1 tbl

FIELD: medicine.

SUBSTANCE: group of inventions relates to medical equipment. Wireless system of cardiac control contains ECG monitor and mobile phone. ECG monitor contains transceiver for wireless transmission of ECG signal data. ECG monitor contains connected with transceiver unit of notification about status for transmission of notification in case of change of ECG monitor status. Mobile phone contains electronics, transceiver for wireless reception of ECG signal data or notifications from ECG monitor and controller for transmission of ECG signal data into the control centre by electronics via mobile connection net. Controller can respond to notification from ECG monitor by communicating notification to patient by means of mobile phone or transmission of notification into the control centre. Notification is communicated to patient by means of mobile phone display, tone signal or verbal prompt, formed by mobile phone. Controller can delay transmission of specified notification into the control centre to give time for reception of notification about status of disorder elimination. When patient is informed about change in status patient is given possibility to answer immediately or to delay respond to notification.

EFFECT: invention makes it possible for patient to recognize and correct situation with changed status without transmission of notification or response of the control centre.

6 cl, 38 dwg, 1 tbl

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine. System of cardiac monitoring contains battery-supplied ECG monitor, which is worn by patient and has processor of patient's ECG signal, device for identification of arrhythmia and wireless transceiver for sending messages about the state and obtaining information about configuration of device of arrhythmia identification. System of cardiac control additionally contains mobile phone, which has electronic devices of mobile phone, transceiver and controller. In the process of method version realisation, parameter of specified arrhythmia to be identified, and limit of switching on alarm signals for specified arrhythmia, are determined and stored in configuration file in the centre of monitoring. ECG monitor is fixed to patient and activated to start ECG monitoring. Message about state is sent by wireless communication line from ECG monitor into the centre of monitoring. Reply to message, which includes only configuration file, is sent to ECG monitor. Configuration file is used to adjust device for arrhythmia identification.

EFFECT: invention makes it possible to provide completely wireless ECG monitoring to increase patient's comfort and convenience.

18 cl, 48 dwg, 1 tbl

FIELD: medicine.

SUBSTANCE: invention relates to medical equipment and is intended for creation of personal medical devices for remote monitoring of patient's heart activity in outpatient conditions - cardiomonitors. Device of mobile communication includes, as minimum, three ECG electrodes, inlet-outlet unit, controller, made with possibility of registration, processing and transmission of information, energy-independent memory, keypad, display, loudspeaker and modem. ECG electrodes are connected with inlet of inlet-outlet unit and are integrated into device case. Device also contains generator and two additional electrodes, which are switched to generator outlet and are intergrated into device case. Controller is made with possibility of rheogram signal registration and analysis of information for self-diagnostics of heart disease aggravation.

EFFECT: application of invention will make it possible to increase self-descriptiveness and reliability of diagnostics due to change of ECG electrode configuration and provision of device with function of rheogram measurement.

3 cl, 2 dwg

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine and medical equipment, namely to electrically isolated catheters and methods of their manufacturing, as well as for integrated circuit of sealed sensor for attachment to sealed case of catheter. Device contains sealed case of catheter, which includes handle and introduced tip for introduction into patient's body, and sealed sensor, connected to introduced tip. Sensor and case of catheter are hermetically isolated from each other. Device also includes local unit of electric power supply/reception of information, built into introduced tip, and made with possibility of wireless emission of signal, which feeds sensor. Sensor is made with possibility of wireless transmission of information signal into local unit of electric power supply/reception of information. During assembly of catheter case of catheter is provided with handle and introduced tip for introduction into patient. After that local unit of electric power supply/reception of information is configured for it to be capable of building into tip for wireless emission of signal which feeds sensor connected to tip, sensor is configured for wireless transmission of information signal into local unit of electric power supply/reception of information and local unit of electric power supply/reception of information is placed in tip. Sensors and catheter case are sealed and sealed sensor is connected to said tip. In alternative version of implementation device contains integrated circuit of sealed sensor for attachment to sealed catheter case. Said circuit is made with possibility of wireless return of information signal into local unit of electric power supply/reception.

EFFECT: group of inventions ensures efficient transmission of energy for electric supply of sensor and possibility of re-application of catheter and its sterilisation.

17 cl, 5 dwg

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to devices of medico-biological purpose, intended for registration and evaluation of fast-proceeding physiological reactions, emerging as response to produced stimuli. Device contains microcontroller, analogue-digital converter (ADC), first commutator, sensors of breast breathing, abdominal breathing, skin-galvanic response, arterial pressure, cardio-vascular activity, sensor of motor activity, power unit, preliminary amplifiers, signal amplifiers, filters, first and second digital-analogue converters (DAC), tool amplifier and unit of connection with personal computer, supplied with galvanic attenuator. Via amplifiers and filters sensors are connected with corresponding inputs of commutator whose controlling input is connected with first microcontroller bus, and output - with first input of tool amplifier. Second input of tool amplifier is connected to output of first DAC, third input - to output of second DAC, and output - to ADC input. Inputs of first and second DAC and group of inputs-outputs of ADC are connected with second microcontroller bus, whose third bus is connected to unit of connection with personal computer. Additional channel has possibility of connection to its input of face mimics sensor, piezoplethysmogram or variable component of skin-galvanic response and includes second electronic commutator, to whose outputs subchannels of processing of signals from corresponding sensor are connected. First subchannel includes successively connected preliminary amplifier and filter, second subchannel - preliminary amplifier, filter, signal amplifier and additional filter, and outputs of subchannels via third electronic commutator are connected to first commutator input. Controlling input of third commutator is connected with microcontroller.

EFFECT: registration of maximal number of physiological parametres and ensuring objectivity of obtained information.

2 cl, 2 dwg

FIELD: medicine.

SUBSTANCE: electrodes of electric ECG potential registration are placed in zone of aorta and in zone of cardiac apex. Changes of electric potential on body in time are registered in form of diagram of ECG function. Near each electrode of ECG electric potential registration additional electrode is installed, onto which high-frequency signal from generator is supplied, and from electrodes of ECG electric potential registration modulated by fluctuations of arterial blood flow signal is obtained synchronously, said signal is amplified, converted into digital code and transmitted for rheogram registration to information processing unit, after which connection of ECG electric potential with change of pressure according to rheogram is connected in each phase, and phase peculiarities of arterial pressure change are diagnosed. Device for synchronous registration of rheogram from ECG electrodes consists of two ECG electrodes, commutator, first amplifier, first band filter, analogue-digital converter, controller, IR transmitter and information processing unit with first detector, commutator being inserted between electrodes and first amplifier, whose outlet through band filter is connected with first inlet of analogue-digital converter, whose outlet is joined to controller, whose first outlet is connected with commutator, and second outlet - with IR transmitter, connected with first detector of information processing unit. Two additional electrodes, second amplifier, second band filter, second detector and generator, switched to additional electrodes, are introduced into it, second commutator outlet is connected to inlet of second detector, whose output through second amplifier and second band filter is connected with second inlet of analogue-digital converter.

EFFECT: synchronous registration of phase characteristics of cardiac cycle and corresponding fluctuations of arterial pressure in heart vessels and aorta.

2 cl, 3 dwg

FIELD: medicine; obstetrics.

SUBSTANCE: fetal cardiac rhythm is registered. Additionally cardiointervalography is performed with determination of spectral power density of maternal and fetal cardiac rhythm waves and selection of very low frequency VLF, low frequency LF and high frequency HF levels, regulator system tension index TI, cortizol and adrenaline level in maternal and fetal blood. Physiological pregnancy course is defined at adrenaline level of 28 ng/mol, cortizol level of 360 ng/ml, indices of VLF=120 relative units, LF=40 r.u., HF=20 r.u., TI=70 r.u., for the mother and at indices of VLF=25 r.u., LF=2 r.u., HF=1 r.u., TI=250 r.u. for the fetus; compensated form of chronic fetoplacental deficiency is detected at the adrenaline level of 46 ng/ml, cortizol level of 695 ng/ml, VLF=180 r.u., LF=50 r.u., HF=100 r.u., TI=160 r.u. for the mother and at VLF=45 r.u., LF=5 r.u., HF=1 r.u., TI=400 r.u. for the fetus; and decompensated form of chronic fetoplacental deficiency is detected at the adrenaline level of 2 ng/ml, cortizol level of 1003 ng/ml, VLF=900 r.u., LF=25 r.u., HF=10 r.u., TI=30 r.u. for the mother and at VLF=3 r.u., LF=1 r.u., HF=0 r.u., TI=700 r.u. for the fetus.

EFFECT: improved accuracy and information capacity of diagnostics of physiological pregnancy course and chronic fetoplacental deficiency forms.

1 dwg, 9 tbl

FIELD: medical engineering.

SUBSTANCE: system has device for measuring and recording biopotentials, device for measuring and recording movement parameters having the first accelerometer, the second accelerometer, the third accelerometer, the first instrumentation amplifier, the second instrumentation amplifier, the third instrumentation amplifier, multi-channel analog-to-digital converter, microcontroller, long-term storage, the first external interface adapter, timer, data analysis device comprising computer, graphic display unit, the second external interface adapter and system interface backbone. The first, the second and the third accelerometers are connected via the first, the second and the third instrumentation amplifiers to multi-channel analog-to-digital converter input cannels. The analog-to-digital converter is connected to the microcontroller. The microcontroller has long-term storage, external interface adapter and timer. The external interface adapter input/output serves as external interface adapter input/output of the device measuring and recording movement parameters. The device for measuring and recording biopotentials is connected to input channel of the device for measuring and recording movement parameters comprising microcontroller input via the second data transfer channel. The first and the second external interface adapters are connected to each other via the first data transfer channel. The computer and the second external interface adapter are connected to each other via system interface backbone. The graphic display unit is connected to the computer.

EFFECT: wide range of functional applications; high diagnosis accuracy.

7 cl, 1 dwg

FIELD: medical engineering.

SUBSTANCE: device has electrodes, preamplifier, microprocessor, memory units of upper and lower level, comparison units, threshold units, unit for producing alarm signal, magnetic recorder, acoustic signalization unit, high frequency generator, amplitude modulator, modulating code oscillator, phase manipulator, power amplifier, transmitting antenna, retuning unit, heterodyne, mixers, intermediate frequency amplifier, detector (selector), amplitude restrictors, synchronous detector, phase detectors, spectrum width measurement units, phase doubler, phase rotator by +90°, adder, multiplier, narrow band filters, amplitude detector, phase divider by 2, phase rotator by +30°, phase rotator by -30° and subtraction units.

EFFECT: improved noise immunity.

3 dwg

FIELD: medical equipment.

SUBSTANCE: system intends for transmitting cardiologic signals along radio channels; it can be used in hospitals, clinics, for ambulance service and at consultation-diagnostic medical centers. System has equipment for serving patient and control board equipment. Patient serving equipment has electrodes, preamplifier, high frequency first generator, first amplitude modulator, modulating code generator, first phase manipulator, first power amplifier, first receiving-transmitting aerial, second heterodyne, second mixer, first intermediate frequency amplifier, first aerial switch, second power amplifier, third heterodyne, third mixer, second intermediate frequency amplifier, second amplitude limiter, second sync detector, registration unit, multiplier, band-pass filter and second phase detector. Control board equipment has microprocessor, comparison unit, lower and top level's memory units, adjusted threshold unit, alarm signal forming unit, magnet registrar, sound signal unit, second receiving-transmitting aerial, tuning unit, first mixer, second intermediate frequency amplifier, detector, delay line, switch, first amplitude limiter, first sync detector, second delay line, first phase detector, high frequency second generator, analog messages source, second phase manipulator, fourth heterodyne, fourth mixer, intermediate frequency amplifier, third and fourth power amplifiers, second aerial switch. Detector has spectrum width measuring unit, phase doubler, second comparison unit and first threshold unit. Radio channel is used in duplex (two-directional) mode when analog and discrete information is transmitted not only from patient to control board but from control board - to patient or to doctor treating the patient.

EFFECT: improved efficiency.

5 dwg

FIELD: medicine; cardiology.

SUBSTANCE: device for registering resulting electrocardiogram at front and horizontals planes has amplifier, analog-to-digital converter provided with multiplexer, arithmetic device, increment code analyzer, first switching unit, digital modem, first memory unit and control-unit, second switching unit, unit for finding direction of electrical axis of heart, first multiplier and first storing adder.

EFFECT: widened functional capabilities.

2 cl, 4 dwg

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