Method for estimating indications for prescribing drug preparations incompatible with alcohol ingestion

FIELD: medicine.

SUBSTANCE: invention refers to medicine and may be used to estimate the indications for prescribing drug preparations incompatible with alcohol ingestion, in addictology, psychiatry, as well as psychotherapy. There are performed electroencephalography and psychological testing: the first stage involves electroencephalography (EEG) in the patients diagnosed with alcohol dependence syndrome for the presence of short wave, desynchronosis and asymmetric bioelectric brain activity, disturbed alpha activity; the given study aims at finding the presence or absence of an organic pathology of brain functioning related to disturbed bioelectric activity. At the second stage, the patients with EEG findings showing no signs of an organic brain involvement are estimated considering the personal nonverbal emotional attitude system using colour repertory grid (CRG) techniques with using groups of alcohol-related objects and displaying Luscher colour cards. Pearson linear correlation coefficients of the elements and constructs to be further processed using a principal component analysis procedure. The detected factor loadings of the two most important components are used as two-dimensional element coordinates when constructing a graphical model of the attitude system of the person being tested. The presence of high conformity in the two representational personal emotional attitude system (verbal and nonverbal) gives evidence of the intact and adequate personality motivation sphere and serves as an indication for prescribing drug preparations of opioid receptor antagonists (naltrexone) and a cognitive behaviour therapy of alcohol dependency. The presence of low conformity is a sign of such disturbances of the motivation sphere that neutralise possibilities of psychotherapeutic methods and serves as a proof for prescribing drug preparations incompatible with alcohol ingestion (disulphiram, cyanamide).

EFFECT: method enables the objective and accurate estimation of the correctness of indications in predicting the effective use of drug preparations incompatible with alcohol ingestion, within the alcohol dependence therapy.

1 ex

 

The method of evaluation of the indications for prescription drugs is incompatible with alcohol.

The invention relates to medicine and can be used to assess the indications for prescription drugs is incompatible with alcohol (disulfiram, cyanamide and the like), in narcology, psychiatry, and psychotherapy.

There is a method of diagnosing psychological characteristics of the individual with the problem of personal status in the addiction field (RU, patent No. 2312597 "Method for the diagnosis of psychological characteristics of the individual using psychotherapeutic kinesiology", 2006).

The disadvantage of this method is nespecificnomu muscle testing, his inability to qualitatively and quantitatively assess the variance in the relationship of personality alcoholic patient.

The closest in technical essence and the achieved result to the invention is a method for diagnosing a pathological craving for alcohol, including electroencephalographic research and psychological testing (RU, patent No. 2139674, "a Method for diagnosing a pathological craving for alcohol", 1999). The method includes electrophysiological studies of patients with alcoholism sequential presentation of olfactory stimuli (neutral, alcoholing is) and further topographic brain mapping of EEG.

The disadvantage of this method is the impossibility of its application for obtaining objective evidence for the appointment of pharmacological drugs that are incompatible with alcohol.

The technical result, which directed the present invention is to improve the accuracy of evaluation of indications and prognosis of the effectiveness of the use of drugs is incompatible with alcohol, in the treatment of alcohol dependence.

This technical result is achieved in that in the method of assessing the indication for the prescription drugs that are incompatible with alcohol included electroencephalographic research and psychological testing, according to the invention the method comprises two stages of the evaluation: in the first stage, patients diagnosed with the syndrome of alcohol dependence (F10.2x) is electroencephalographic study (EEG) in the presence of slow waves, the timing and asymmetry of bioelectric brain activity, violations of the alpha rhythm, the results of this study to determine the presence or absence of organic pathology of brain functioning that is associated with the violation of his bioelectric activity; in the second stage, patients which according to the results of EEG revealed no signs of organic p. the expressions of the brain, undergo assessment system deverbalization emotional relationship to the person using the technique of color repertory grid (CRR), repertory grid (PP) is a matrix to be filled in the survey process, the columns of the matrix corresponds to the required psychodiagnostic group of objects, called elements, and the elements can be people, objects, concepts, relationships, and the rows of the matrix are constructs bipolar characteristics, parameters, scales, by which the subject evaluates, describes and organizes the objects of the world - elements, in the course of the study constructs or specified by the researcher, or detected in the subject using a special procedures for the identification, and in the process of completing repertory grid subject evaluates each object (element) for each construct, and the mapping between elements and constructs indirectly through the layout of the Luscher colour cards: first, the subject is invited to have 8 colors Luscher test in order to match each element of the PP, from the most similar suitable element colors to the different, inappropriate, then the subject is asked to place the same 8 colors between the poles of each of the constructs PP, using the same principle, with each cell battery (included) the tov and constructs have the subject separately, so the subject was not aware of their subsequent mixing in one matrix (lattice), while for quantitative localization of any item on the scale, given by the poles of any of the constructs that produce a comparison of the ranking of the locations of each color Luscher test in two layouts: 1 - ranking of the colors in the order of relevance to the given element, 2 - ranking of colors in order to match the poles of a particular construct. Next, calculate the K-factor is a quantitative measure that defines the location of the item on the scale of the construct, which may vary from 0 to 32, which sets quite subtly differentiated scale factor K is calculated by the formula:

|di|the absolute values of differences i-x ranks (ordinal places) color Luscher test in the above two layouts, then calculate the coefficients of Pearson's linear correlation between the elements and between the constructs, which subsequently subjected to further processing using the method of principal component analysis, with parameters of the factor loadings on the two most important components are used as coordinates in a two dimensional space when building graphical mo the eating attitudes test, the presence of high coherence in two representative systems of relations of the individual (verbal and non-verbal) evidence about the safety and adequacy of the motivational sphere of personality and is the indication for drug prescribing group of antagonists of opioid receptors (naltrexone) and course of cognitive-behavioural psychotherapy in the treatment of alcohol dependence, and the presence of low consistency between verbal and non-verbal systems of relations of identity is a symptom of such disorders in the motivational sphere, which negate the possibility of psychotherapeutic methods and also serve as evidence for the purpose of drugs is incompatible with alcohol (disulfiram, cyanamide).

Color test relations (TSC) is a clinical diagnostic method designed to explore the emotional component of the relationship of man to important to his people and phenomena, reflecting both conscious and partly unconscious levels of these relations (Bazhin E.F., Etkind A.M. Colour test of relations: Methodological recommendations. Leningrad: Izd-vo LNIPE them. After academician V.M. bekhterov, 1985, p.3). Contents sensual, visually-shaped relationship, if they are not adequately understood by patients, as a rule, a considerable part of the pathogenetic importance is imich experiences. In comparison with the methods of research relationships based on verbal self-reports of patients that reflect, as a rule, only perceived available verbalization layer relations, methodology TSC seems to be more informative, allowing to estimate partially conscious, emotional layer relations.

The known method with the use of TCCs gives an indication only of the polarity relationship of subjects to the different semantic elements. The way is not possible to know, based on what experiences, assessment categories, personal, meaningful semantic entities this relationship has acquired a specified polarity. The known method has the framework of the existing shades of meaning relations. Identified in the application method, the relationship appears to be linear, elongated along the bipolar axis in one-dimensional space.

In addition, the technique of color repertory grid (CRR) is aimed at building a system of relations of individuals in a multidimensional space, where the axes are personal constructs (sense of education, through which the individual perceives, evaluates and structures of the phenomena and events of reality). The proposed method allows you to build and analyze complex, three-dimensional, categorical due to system emocjonalnejtest personality. In addition, the procedure is constructed in such a way that the subject is virtually impossible to imagine how his direct answers will affect the outcome of the study. While performing the known method using TCCs subject to a significant degree can imagine how his answers will affect the result. Therefore, the proposed method allows much closer than the known method, approach to reclamation, the unconscious components of the personality of the subject.

Thus, the proposed solution allows the results of the EEG to determine the patient the presence or absence of organic pathology of brain functioning that is associated with the violation of his bioelectric activity; patients in whom the results of the EEG revealed no signs of organic brain damage, pass the appraisal system deverbalization emotional relations, to create the most objective view about the emotional landscape of intrapersonal space. That will allow you to objectively and accurately assess the correctness of the indications in the forecast the effectiveness of medications that are incompatible with alcohol, in the treatment of alcohol dependence.

The method of assessing the indication for the prescription ven the preparations, incompatible with alcohol, as follows.

In the first stage, patients diagnosed with the syndrome of alcohol dependence (F10.2x) is electroencephalographic study on the presence of slow waves, the timing and asymmetry of bioelectric brain activity, violations of the alpha rhythm, the results of this study to determine the presence or absence of organic pathology of brain functioning that is associated with the violation of his bioelectric activity.

In the second phase, patients in whom the results of the EEG revealed no signs of organic brain damage, pass the appraisal system deverbalization emotional relationship to the person using the technique of color repertory grid (CRR).

Repertory grid is a matrix that is filled either by subjects or by the experimenter in the survey process. The columns of the matrix corresponds to a certain group of objects called elements. As elements can be people, objects, concepts, relationships are all that interested in psychodiagnostic. For example, in the form of Repertory grid test proposed by the author of the method - Kelly submitted a list of 22 characters (Fransella F., Bannister D. "a New method for the study of personality". the owner's manual for repertory personal techniques: trans. from English., General Ed. and Preface Umesababisha and Whiporwill. - M.: Progress. 1987, p.61).

1The person concerned
2His mother or a woman who had replaced the mother
3The father or the man who replaced father
4The brother closest in age or someone who was the subject for brother in adolescence.
5The sister closest in age or someone who was the subject as a sister in adolescence
6Wife (husband) of the examinee or his lover(s').
7Beloved(tion), the immediate predecessor(nick) the one (that), who listed above.
8The closest currently a friend of the same sex with the test
9Man one with the test floor, which he considered a close friend, but which disappointed
10 The Minister or priest, with which the subject would like to share your views
11Doctor
12The neighbor, which is the subject now knows better than others
13The person who rejects (with whom the subject was connected and which for some inexplicable reason, disliked it)
14The man regrets (feels a sense of pity and would like to help)
15People that represents a threat (in his presence feels uncomfortable)
16The man who attracts (recent acquaintance, who would like to know better)

17Accept the teacher (who had the most influence when I was a teenager)
18Reject the teacher (whose views expressed strong objection)
19Head (under whose leadership has survived although the white days)
20Successful people (lucky)
21Happy people
22Moral man

Proposed method, the elements are not fixed - every developer of a new grid can modify this list to meet their specific requirements. Here are examples of different sets of items used by the researchers: profession, emotions, situations, illness, shops, mythological beings, the relationship between specific people. Variants of itemsets can be endless, however, they must meet two requirements: 1) items must be in the range of suitability of the used constructs (for example, if the constructs are used taste, should not be included models of washing machines); 2) the items should be representative of the sample on which they are examined.

The rows of the matrix are the so-called constructs bipolar characteristics, parameters, scales, by which the subject evaluates, describes and organizes the objects in the world - the elements. The constructs according Gscale, the author of the method repertory R is setok and theory constructs, - this is a special subjective properties, semantic relations, created or acquired by the man himself, and tested them in practice, with the help of which a person perceives, organizes, and interprets (constructs) reality itself, predicts and evaluates events, organizes their behavior. In the most General form of the construct is bipolar symptom, alternative, opposing attitudes or behaviors (Zabrodin, Y.M., pokhilko VI Theoretical origins and purpose of the personal repertoire of techniques, Fransella F., Bannister D. a New method of personality research. - M.: Progress, 1987, p.17). It should be emphasized that the construct is not only independent of meaning formation, method of differentiation of the objects in the world, but this form of attitude and behaviour. Construct, enshrined in the repertory grid in the form of a verbal label, in the consciousness of the individual is relevant psychological reality. This constructs do not exist in isolation: they interact with each other and are connected through a complex hierarchical relations, i.e. arranged in the system.

The study constructs or specified by the researcher, or detected in the subject using special procedures are identified. In the process of completing the repertory grid test subject must evaluate each volume is t (element) for each construct. In the case of color repertory grid mapping between elements and constructs indirectly through the layout of the Luscher colour cards. This happens as follows. First, the subject is invited to have 8 colors Luscher test in order to match each element of the PP, from the most similar suitable element colors to the different and wrong. The same procedure is used in the color test relations. Then the subject is proposed to have the same 8 colors between the poles of each of the constructs PP, using the same principle. Each of the elements and constructs of the subject is presented separately, so that the subject knew nothing about their subsequent mixing in one matrix (lattice). For the quantitative localization of any item on the scale, given by the poles of any of the constructs, compares the ranking of the locations of each color Luscher test in two layouts: 1 - ranking of the colors in the order of relevance to the given element, 2 - ranking of colors in order to match the poles of a particular construct. Further, according to the special formula, calculate the K-factor is a quantitative measure that defines the location of the item on the scale of the construct, which may vary from 0 to 32, which sets quite subtly differentiated scale. In the formula in which the calculations of the K-factor:

|di|the absolute values of differences i-x ranks (ordinal places) color Luscher test in the above two layouts.

The presence of a specially designed computer program can significantly reduce the time required to carry out procedures of ranking when working with a patient and subsequent mathematical processing.

For example, let the examinee placed 8 color Luscher test in order to match the image of a "friend", which is one of the elements of the lattice. Then he placed the same 8 colors between the poles of the construct "outdoor man - secretive man", which is one of the constructs of the same lattice, also in order of relevance to the poles of the construct. Comparing quantitatively according to the formula above ranks (ordinal locations) of flowers in these two layouts, we will be able to locate the item "other" on the scale of the construct of "outdoor man-secretive man." Thus, we will be able to judge how in the field of emotional perception of the test similar relationship to the images of "the other" and "open (secretive) man, and hence his unconscious emotional assessment of how, for him, the other is open or secretive h the man.

Layout 8 color Luscher test has a large number of possible variants (40320 by the formula for the number of placements), which makes the method evaluation system deverbalization emotional relationship of personality sufficiently precise, subtle and differentiated assessment tool. Whereas in verbal PP the number of possible vzaimoprityazhenie elements and constructs is limited to their number.

The procedure for creating a color PP based on consecutive projecting elements of the world and personal constructs in the internal personal colour symbolism, which everyone possesses, and which is quite stable. But since this hierarchy is only a measuring tool to determine the relationships between elements and constructs, the structure of the lattice is substantially independent and stable.

In the course of the examination subject is not aware of the ultimate objective: 't know about the subsequent mapping of elements and constructs and building a repertory grid. Therefore, its results are actually deprived of the influence of factors such as the propensity of patients with addictive disorders to simulation or dissimulation, the activity of psychological defense mechanisms. Thus, this method of evaluation system deverbalization emotional relationship of personality has a high grade is Yu objectivity.

Evaluation system deverbalization emotional relationship of personality allows the flexibility to modify the stimulus material depending on the goals and objectives of the research interests of the examination of the individual patient. For example, in the case of patients with addictive disorders as constructs can be used quality describing various aspects of addictive behavior: "able - unable to control the intake of psychoactive substances (surfactants)", "social - antisocial", "care - does not care about health, etc. as elements of color repertory grids in the survey of addictive patients can perform various aspects of the "I" of the subjects or social roles related to the disease: "I'm sober", "I'm drunk", "I in abstinence", "Teetotaler", "Moderate drinker", "Drunkard", "Addict", etc. In order to estimate the location of the data elements in the coordinate system of the emotional relationship of the individual in relation to such items as "I in the past", "future", "I currently have", "the Perfect Me", "Happy man", "Man I despise" etc. This comparison allows not only to determine the pole of the emotional relationship of the subject to the various aspects of addictive behavior, but also to get an idea about the semantic orientation of the different emotional content of these relations. Investigated using this method, the attitudes and experiences of patients are the core of "rehabilitation background as aspect of addictive status of the patient.

The method of assessing the indication for the prescription drugs that are incompatible with alcohol, illustrated by the example of a specific implementation.

Example.

Patient A., 38 years. Heredity burdened by alcoholism father and grandfather. Systematically alcoholized 27 years. Alcohol withdrawal syndrome (LAS) with 32 years. Drink alcohol in shape with daily tolerance of 0.75 liters of vodka. Previously, the addiction is not treated. Psychosis, seizures denies. Admission is AAC, complains of internal stress, General discomfort, tremor of hands, craving for alcohol. Against the backdrop of ongoing detoxification therapy AAS cropped to 6 days. After stabilization of somatic and mental state due to cancellation of drugs the patient underwent EEG study, which found no violations of the bioelectrical activity of the brain.

As items were set by the experimenter following: "I'm real", "in the past I", "I ideally", "alcoholic", "someone I want to be like". Common designations of colors in the test Luscher are:

0 grey

1-blue

2 green

3 - orange

4 - yellow

5 - purple

6 brown

7 - black

8 during the examination the patient is arranged colors for each element as follows:

Rank12345678
"I'm real"43617502
"In the past I"02564371
"I ideally"53164728
"Alcoholic"02467135
"someone I want to be like"10274653

With respect to the set for this study constructs a patient arranged colors as follows:

12345678
independent, able to work independently20764135not able to make independent decisions
responsible, has a sense of duty20476135irresponsible, unable to keep the word
with good self-control, restrained20476135poor self-control, impulsive
strives for a happy family life35167 28not seeking happiness in family
confident, has internal integrity53167420not sure, riven by internal contradictions

Next, for each pair of constructs and elements of the above formula calculates the coefficient For defining the position of the item on the scale construct. As a result of the impressions we get this table:

Constructs"I'm real","in the past I""I ideally""alcoholic""someone I want to be like"
independent, not able to make independent decisions281430 612
Responsible irresponsible261632412
with good self, bad self-control261632412
committed to family life - not seeking happiness in family142643028
confident - not sure142623028

Then calculated the correlation coefficients between items and between constructs, which subsequently undergo further processing using the method of principal component analysis. The identified indicators are used as the coordinates of the elements when building a graphical model of the system tested. In this case, the results of these studies the project, presented in graphical form, look like this.

∗I ideal
∗I real
∗I in the past
∗, The person I want to be like
∗an alcoholic

The results of performance data test method suggests that it was considering its condition at the time of treatment as approximating it to the ideal state. That is, at the level of emotional relations, he considers the treatment as "positive" - "useful". On the other hand, the item "someone I want to be like" is close to all the elements of "alcoholic" and "I in the past." This suggests that at the subconscious level of the examined remains intent on maintaining a behavioral characteristic of individuals with alcohol dependence, a certain emotional appeal of the image of the drinker. This configuration in the system emotional relationship indicates an internal inconsistency, intrapersonal conflict-related immaturity installation sobriety, insufficient readiness of criticism to the TB is evania. This information, in turn, indicates a lack of readiness of the patient to self-maintain sobriety lifestyle and the need to continue treatment and rehabilitation impact, and also determines the direction of psychotherapeutic and psycho-work.

The evaluation system deverbalization emotional relations of the individual patient using the repertory grid technique were found to be little consistency between verbal and non-verbal systems of relations of the individual, which means difficulties in the formation of significant personal installation on sobriety and serves as an indication for drugs that are incompatible with alcohol (disulfiram, cyanamide) for the prevention of alcoholic relapse. At the time of discharge, the patient's condition is good. Recommended taking disulfiram or cyanamide under the supervision of relatives. At the reception later, 3 months after hospital treatment - the patient is in remission, the attraction to alcohol denies, background mood smooth, raised, mental and somatic state of normal.

The method of assessing the indication for the prescription drugs that are incompatible with alcohol, allows the results of the EEG to determine the patient the presence or absence of the content of inorganic fillers pathology of brain functioning, associated with the violation of his bioelectric activity; patients in whom the results of the EEG revealed no signs of organic brain damage, pass the appraisal system deverbalization emotional relations, to create the most objective view about the emotional landscape of intrapersonal space.

The proposed method of assessing the indication for the prescription drugs that are incompatible with alcohol, allow to objectively and accurately assess the correctness of the indications in the forecast the effectiveness of medications that are incompatible with alcohol, in the treatment of alcohol dependence.

The method of assessing the indication for the prescription drugs that are incompatible with alcohol, developed and approved in St.-Petersburg research Psychoneurological Institute. After academician V.M. bekhterov.

The method of assessing the indication for the prescription drugs that are incompatible with alcohol, including electroencephalographic research and psychological testing, characterized in that the evaluation is carried out in two stages: in the first stage, patients diagnosed with dependence syndrome alcohol conduct EEG research (EEG) in the presence of slow waves, the timing and asymmetry bio is elektricheskoi brain activity, violations of the alpha rhythm, the results of this study to determine the presence or absence of organic pathology of brain functioning that is associated with the violation of his bioelectric activity; in the second stage, the patients in whom the results of the EEG revealed no signs of organic brain damage, pass the appraisal system deverbalization emotional relationship to the person using the technique of color repertory grid (CRR), repertory grid (PP) is a matrix to be filled in the survey process, the columns of the matrix corresponds to the required psychodiagnostic group of objects, called elements, and the elements are people, objects, concepts, relations, and related with alcohol, and the rows of the matrix are constructs bipolar characteristics, parameters, scales, by which the subject evaluates, describes and organizes the objects of the world - elements, in the course of the research constructs are specified by the researcher, and in the process of completing repertory grid subject evaluates each element on each construct, and the mapping between elements and constructs indirectly through the layout of the Luscher colour cards: first, the subject is asked to have 8 colors Luscher test in order according the each of the elements PP, from the most similar suitable element colors to the different, inappropriate, then the subject is asked to place the same 8 colors between the poles of each of the constructs PP, using the same principle, with each of the elements and constructs have the subject separately, so that the subject did not know about their subsequent mixing into one matrix, while for the quantitative localization of any item on the scale, given by the poles of any of the constructs that produce a comparison of the ranking of the locations of each color Luscher test in two layouts: 1 - ranking of the colors in the order of relevance to the given element, 2 - ranking of colors in order to match the poles of a particular construct, then calculate the K-factor is a quantitative measure that defines the location of the item on the scale of the construct, which may vary from 0 to 32, which sets quite subtly differentiated scale factor K is calculated by the formula:

where |di| is the absolute value of the difference of the i-th rank - ordinal places flowers Luscher test in the above two layouts, then calculate the coefficients of Pearson's linear correlation between the elements and between the constructs, which subsequently subjected to further processing using the method of principal component analysis, which revealed indicators of factor loadings for two, the most significant components are used as coordinates in a two dimensional space when building a graphical model of a system of relations of the subject, and the presence of high coherence in two representative systems of relations of the individual attests to the safety and adequacy of the motivational sphere of personality and is the indication for drug prescribing group of antagonists of opioid receptors and course of cognitive-behavioural psychotherapy in the treatment of alcohol dependence, and the presence of low consistency between verbal and non-verbal systems of relations of the individual is a sign violations in the motivational sphere, leveling capabilities psychotherapeutic methods, and serves as an indication for drugs that are incompatible with alcohol.



 

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2 tbl, 10 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine and medical psychology, more specifically to the occupational adaptation assessment of mid-level health workers. What is involved is psychological testing of professional burnout, family relationship, active calling strategies, and objective functional status. The derived values are used to calculate linear discriminant functions (LDF) as per two assessment rates: LDF1 shows the risk factors of the occupational deadaptation; LDP2 provides stating the high occupational adaptation; the mid-level health workers have been grouped considering the highest LDF with a sign character: LDF(=-604.151-4.550X1+1.021X2+1.270X3-0.203X4-0.142X5+3.136X6+346.786X7+11.566X8; LDF2=-637.127+4.957X1+1.305X2+1.131X3-0.230X4-0.149X5+3.237X6+360.126X7+11.904X8, wherein X1 is assessed by the Independence scale; X2 is assessed by the Family Relationship Establishment scale; X3 is assessed by the PCI Preventive Management scale; X4 is the MBI generalised estimate; X5 is the blood circulation efficiency factor; X6 is the birth-death ratio; X7 is the functional change index; X8 is the stroke volume.

EFFECT: method enables the occupational adaptation assessment ensured by including the objective functional status and mathematical expressions of the regression analysis.

2 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, in particular to psychiatry and can be applied for psychopathological estimation of psychic state of infants and preschool children. To perform psychopathological estimation of psychic state of infants and preschool children estimation of child's psychic and neurological state is performed. As symptoms of patient's psychic state estimated are state of sphere of cognitive functions: play, thinking, memory, speech; state of sphere of psychic activity: aim-oriented behaviour, volitional desires, motives, workability; state of emotional sphere, sphere of attraction, sensor perception, impairment of perception: acousma, photopsia, hallucinations, self-consciousness and state of sphere of social behaviour: communication disorders, autistic symptom, social skills. As symptoms of patient's neurological state, state of sphere of neurological signs, motor activity and state of initial vegetative tome - vagotonia and sympaticotonia are estimated. Estimation of each symptom is performed in points from 0 to 7. Total value of average point of identified symptoms for each sphere, reflecting severity of patient's psychic and neurological state, is calculated. Average points are summed up for each sphere and severity of state is determined in accordance with determined values, namely if the total sum of average points is from 0 to 9, psychic state is estimated as child's practical health; if value is from 10 to 18 points, presence of boundary psychic disorders is estimated, from 19 to 27 points - as mild severity of psychic disorders, from 28 to 36 - as moderate severity, from 37 to 45 points - as medium, from 46 to 54 - as severe, from 55 to 63 points, psychic state is estimated as extremely severe degree of psychic disorders.

EFFECT: method makes it possible to increase accuracy of psychic state of infants and preschool children due to application of differential and diagnostic criteria of symptoms of psychic disorders.

4 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to anaesthesiology, and may be used in assessing an adequate general anaesthesia in the children aged from 4 to 14 years old. That is ensured by pre-anaesthetic and intra-anaesthetic intraoperative recording of long-latency auditory evoked potentials. That is followed by summing up initial latencies of first three pre-anaesthetic peaks (P1, N1, P2) to calculate sum A, subtracting the sum of the latencies of the first three intraoperative peaks (P1, N1, P2) to calculate sum B. The A to B relation is multiplied by 100. A percentage of the latencies of the intra-anaesthetic peaks P1, N1, P2 to the pre-anaesthetic values is considered as the adequate general anaesthesia. For the children of the first age group of 4-6 years old, the general anaesthesia is considered to be adequate, if the percentage is 140-253%; for the children of the second age group of 7-9 years old, the adequate general anaesthesia is shown by the percentage of 133-253%; for the children of the third age group of 10-12 years old, the adequate anaesthesia is shown by the percentage of 159-190%; and the percentage of 125-271% provides the adequate general anaesthesia for the children of the fourth age group of 13-14 years old.

EFFECT: method provides the adequate and easy assessment of the anaesthesia ensured by reducing a time of examination and simplicity of data interpretation in the form of one three-peak wave.

1 ex, 6 tbl

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to neurophysiological methods of examination. Registration of EEG is carried out, total power of modal fluctuation in alpha-rhythm range in one of leads is determined and FRα1 index is calculated as ration of said power to total power of all alpha range fluctuations in the same lead. Value of the sum of power of fluctuations, located ±0.5 Hz on the right and on the left from maximal power value, including maximal value, is determined, and FRα2 index is calculated as ratio of the obtained sum of power to total power of all fluctuations of alpha-range in the same lead. Intensity of brain affection is determined by comparison of obtained FRα1 and FRα2 values with standard values.

EFFECT: method makes it possible to determined quantitative ratio of alpha-rhythm, characteristic of separate nosologic units in psychiatry.

2 tbl, 1 dwg

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to pediatrics and can be used in neurology, medical psychology and psychiatry. Clinical examination of children is carried out by complaints, anamnestic information and data of physical examination. Assessed are: symptoms of vegetative manifestations at the moment of examination and peculiarities of sensomotor reactions: weight and length of body at birth, gestation age, response to stimulation in children of first year of life, sleep in children of first year of life, EEG in children of early age, parasomnia, enuresis, meteosensitivity, headaches, vessel lability, vestibulopathy, peculiarities of motor sphere, feeding behaviour, skin manifestations, course of infectious and somatic diseases, menstrual disorders in adolescent girls, brain ultrasound examination. Connection of said disorders with predominant dysfunction of right or left brain hemispheres is determined.

EFFECT: method makes it possible to increase reliability of diagnostics, which is achieved due to taking into account vegetative reactions and disorders in child of first year of life.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to oncologic neurosurgery, neurology, psychiatry and functional diagnostics. Electroencephalographic examination is carried out. Level of coherent connection between pole-frontal and anterior temporal regions of cerebral cortex on the right is calculated in beta-range. If said parameter is higher than 0.52, Korsakoff's syndrome is diagnosed.

EFFECT: method makes it possible to increase reliability of Korsakoff's syndrome diagnostics.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to drug-free methods for activation of the cerebral verbal functions. Cerebral signals are recorded. Their duration is measured. A related verbal stimulus is established for the derived wave duration and has an effect on the patient. That is followed by measuring the duration of the next current wave through a time interval not less than the maximum duration of the used verbal stimuli, and the patient is exposed to the verbal stimulus corresponding to the current wave. According to the other version of implementing the method, the duration of the current wave is measured, and the corresponding verbal and contextually harmonised visual stimuli are set for the above duration. The patient is exposed thereto. That is followed by measuring the duration of the regular current wave through a time interval not less than the maximum duration of the used verbal stimuli, and the patient is exposed to the verbal and contextually harmonised visual stimuli corresponding to the current wave.

EFFECT: invention enables acceleration the process of verbal development in children.

1 dwg, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to neurology, psychiatry and pediatrics. Factors of perinatal pathology risk are determined: extragenital diseases of mother during pregnancy and labour, complications of pregnancy and labour, low gestational age, estimation by Apgar scale and compromised obstetric history. Also determined is presence of neurological malfunctions during 1-st year of life: syndromes of motor malfunctions, increased neuroreflex excitability, vegetative-visceral disorders, depression, retardation of physhomotor and speech development; and in older age - cerebrosthenic syndrome and syndrome of child dysphasia in structure of symptom complex of MBD, epileptiform activity by EEG. Results of questionnaire for MBD detection are evaluated in points. Prognostic coefficients F1 and F2 are calculated in discriminating equations. If F1 is higher than F2, favorable courseof MBD is predicted, if F1 is less than F2, unfavorable course of MBD is predicted.

EFFECT: method makes it possible to increase reliability of MBD course prediction.

2 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine. Electroencephalogram (EEG) is registered in background mode, spectrograms are calculated by means of wavelet conversion with Morlet mother function. Frequency ranges of leading EEG rhythms are determined by finding values of coordinate minimums by frequency of envelope projections of wavelet spectrograms on "amplitude-frequency" coordinate plane. In frequency ranges times Ti of spectrogram peak appearance are determined by values of positions of maximums on envelope projection of wavelet spectrograms. Frequencies Fi and amplitudes Ai of peaks of spectrograms, which correspond to values of times of their appearance in each frequency range, are determined. For each discretisation window with ΔT, ΔF parameters, obtained by fragmentation of duration T and frequency range F of EEG registration, values ΣAi of sums of amplitudes of spectrogram peaks are calculated. If frequency increases, range of frequencies of peaks expands, interhemispheric asymmetry of electric activity is detected, early stage of Parkinson disease is diagnosed.

EFFECT: method makes it possible to increase reliability of determination of early stage of PD.

4 cl, 9 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to functional diagnostics. Electroencephalogram (EEG) is registered, indices of averaged powers of spectra in background EEG registration in frequency range 8-13 Hz MI before 1up to 16 minute long HF impact and M2 after EHF impact consisting of 6-10 procedures are determined. Dynamics of ratios of said indices of powers M2/M1 presence of compensatory reserves of brain is determined. In case if ratios M2/M1, equal more than 1.2 are present, conclusion about positive dynamics of general functional state of brain an possibility of carrying out standard EHF therapy is made.

EFFECT: method extends arsenal of means for control over state of patient with encephalopathy in EHF therapy.

6 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to field of medical and psychophysiological diagnostics. Assessment of character of motor asymmetries - determination of degree of right-handedness - left-handedness by dominance of hand and leg, as well as sensor asymmetries - determination of leading eye and ear, is performed. Also calculated is coefficient of amplitude and frequency of mu-rhythm in central parts of left and right hemisphere, as ratio of difference of maximal and minimal values to their sum. Difference between maximal and minimal values is calculated within 3-second long interval. Dominating hemisphere of motor cortex by mu-rhythm is registered at the moment of alternate clenching right and left hand fist with application of sensomotor test by scheme: "Close eyes - make right fist - open eyes - undo the fist", "Close eyes - make left fist - open eyes - then undo the fist', during standard registration of electroencephalogram.

EFFECT: method extends arsenal of means for assessment of functional interhemispheric asymmetry.

9 dwg, 4 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to neuroinfections. Assessment of anamnesis data, virological indices, fever reaction and spotty-papular rash appearance is carried out. EEG is additionally registered in the first three days from the moment of admission, leukocyte index of intoxication, presence of mixed hypervirus infection are determined. If hypoxy-ischemic affection of central nervous system, spotty-papular rash on the body from the first day of disease with its "additional appearance" during 5-7 days, fever to 39-40°C during first 3-5 days are present in child's anamnesis, reduction of index of main physiological rhythm less than 30%, increased paroxysmal activity in form of diffuse sharp waves and flashes of slow activity with amplitude more than 100 mcV during 3 days or at least on one of these days are detected on EEG, value of leukocyte index is 0.2-3 conv.units, mixed hyperviruses together with varicella zoster virus, virus of type 6 herpes and/or type I herpes simplex virus are detected, risk of neurological complications is predicted.

EFFECT: method makes it possible to increase reliability of predicting risk of neurological complications in case of chicken pox in children.

3 ex

FIELD: medicine, neurology, psychopathology, neurosurgery, neurophysiology, experimental neurobiology.

SUBSTANCE: one should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another.

EFFECT: higher accuracy of diagnostics.

5 dwg, 1 ex, 1 tbl

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