Method for antimicrobial photodynamic therapy of acute inflammatory diseases of laryngeal pharynx and suppurative complications

FIELD: medicine.

SUBSTANCE: starch or sorbite photosensitiser powder is administered into a laryngeal pharynx that is further exposed to laser light. The laser light exposure is performed at wave length 0.685 mcm, powder 18-20 mWt, energy density 18-28.8 J/cm2.

EFFECT: implementing the method provides the reliable laryngeal fixation of the photosensitiser, maintains the constant concentration of the photosensitiser for the whole therapeutic session, and thereby faster reduction of the inflammatory process.

2 cl, 4 ex

 

The invention relates to medicine, namely to otolaryngology, and can be used for antimicrobial photodynamic therapy of acute inflammatory diseases of the hypopharynx or purulent complications.

Currently, for the treatment of purulent-inflammatory diseases of the hypopharynx is widely used antibacterial therapy (S.N. Kozlov Antibacterial therapy: a Practical guide. - M. 2000. - S). Often prescribe a combination of two or more antibacterial agents, in order to cover the range of potential pathogens. Despite the constant improvement of methods of diagnosis and treatment of acute inflammatory diseases of ENT-organs and their purulent complications over the past few years there has been a steady increase in incidence among the working age population. Primarily this is due to uncontrolled prescribing and use of antimicrobials. It is unreasonable use of antimicrobial drugs has led to the emergence of complex problems of antibiotic resistance by the early 70 agricultural substantially changed the species composition of the microflora in the predominance of staphylococcal and conditionally pathogenic flora. The problem of antibiotic resistance, acute at the time, forced the practitioners to increase the dosage of antimicrobic chemotherapy, often to change medications, and scientists to seek new group of antibacterial agents.

In connection with a reduction in the effectiveness of antibiotic therapy, education, resistant to most known antibiotics of strains, the increase in the number of postoperative infectious complications, low efficiency of the most common methods of therapy, duration of the treatment period, exclusive of the cost of the use of antimicrobial therapy in search of new ways of treatment of purulent-inflammatory processes of ENT-organs at all stages of medical science is relevant.

One of the most progressive methods of treatment of acute inflammatory diseases of the hypopharynx and purulent complications is laser and laser therapy, extracorporeal laser or ultraviolet blood irradiation (V.T. palcon, A.S., Lapchenko, Dilmurat. "Inflammatory diseases of the larynx and their complications), 2010, Pp.163). In addition, the progress of laser medicine has led to the emergence of a fundamentally new way of influence on biological objects associated with the interaction of the focused laser radiation and a new class of pharmacological agents - photosensitizers. Method of treating inflammatory and proliferative diseases, malignant neoplasms, based on the application fot the dynamic effects on pathological objects (cloth, bodies), is called photodynamic therapy (PDT).

Targets of antimicrobial photodynamic therapy are viruses, bacteria, fungi and protozoa. The selectivity of the method determined by the local delivery of photosensitizer and light to the infected area and more depending on species sensitivity to photodynamic effects in microorganisms compared with animal cells. When this happens their selective destruction in the joint effect of the photosensitizer and coherent or incoherent radiation.

The known method of antimicrobial photodynamic therapy of severe septic complications of inflammatory diseases of ENT-organs with the use of cationic phthalocyanines ZnPcPym8and ZnPcChol8(RF patent 2282647, C09B 47/32 from 27.08.2006,). In this way photodynamic therapy was started immediately after surgical opening of purulent foci and carrying out emergency and resuscitation. As a light source is used, the radiation of the semiconductor laser therapeutic instrument "Mustang" with a wavelength of 0.67 microns, with a capacity of 24 mW.

therapy consisted in the fact that the cavity is surgically opened the abscess was laid gauze wipes impregnated with a solution of a photosensitizer, the time from 10 minutes to 24 hours We then conducted the irradiation of purulent wounds with exposure time of 7 minutes the Procedure was performed daily until complete cleansing wounds from pus and wound detritus, from 5 to 10 treatments on the course of treatment depending on the severity and prevalence of purulent process. At the end of the course of PDT and the disappearance of signs of wound infection last usualis again delayed seams.

The disadvantages of this method are that it may be used only when performing percutaneous surgical opening of the abscess, as well as failure to maintain the required stable concentration of the photosensitizer during the whole session of photodynamic therapy.

Known another method of treatment of purulent diseases of the larynx using cationic phthalocyanines ZnPcPym8and ZnPcChol8(RF patent 2361633, from 20.07.2009, prototype). The method was to spray through the inhaler of the photosensitizer in the cavity of the larynx, through the introduction of common nasal passage of the fiber and further irradiation inflamed areas of the larynx. The method includes the use of led phototherapy apparatus ASF "Solaris" with wavelength 0,675 μm, the radiation power output of 40 mW in continuous mode, using the nozzle-fiber for ENT with a diffuser to the apparatus ASF, the diameter of the cone 1, cm, the length of the diffuser (edge emitting) 2 cm, the radiation power at the fiber output 15-24 mW. For delivery of the sensitizer used ultrasonic nebulizer "monsoon+1" for delivery of the photosensitizer. As a photosensitizer were applied mentioned cationic phthalocyanines in a concentration of 1.5 to 6.5 microns.

The method of treatment is as follows: the patient through freer half of the nose, after a preliminary adrenalize injected PVC catheter with an inner diameter of 2 mm, through which is conducted the nozzle-fiber for ENT with a diffuser connected to the led phototherapy apparatus ASF "Solaris", and spend it through a common nasal passage, throat and later in the eve of the larynx.

The ultrasonic nebulizer "monsoon+1" fill 20 ml of photosensitizer at a concentration of 1.5 to 6.5 microns and include in the network. When the volatilization of the patient inhales mouth the mixture for 2 minutes. Then, without stopping the inhalation mixture, begin conducting photodynamic therapy using previously entered the light guide, for 10 minutes, then remove the fiber and inhalation of photosensitizer stop.

The treatment is 3-10 sessions held daily, once a day.

The disadvantages of this method is that its application is possible only after the e introduction of fiber through the free half of the nose, that extremely negative tolerated by many patients. Also the use of inhaled photosensitizer is not possible to reliably fix the photosensitizer in the cavity of the larynx, it is not possible to achieve a stable concentration of the photosensitizer during the whole session of photodynamic therapy and stretches the treatment of PDT to 10 sessions.

The objective of the invention is development of a method of treatment of acute inflammatory diseases of the hypopharynx or purulent complications method of photodynamic treatment with maintenance of a constant concentration of the photosensitizer during the entire treatment session.

The problem is solved in that in the cavity of the larynx or pharynx using a special spray injected photosensitizer (PS) in powder form based on sorbitol or starch concentration FS 0,5%-1,0% method insufflation, then into the cavity of the larynx enter the optical fiber from the laser therapeutic and carry out the irradiation of the inflamed areas of the larynx or abscess cavity laser with a wavelength of 0,685 μm, the radiation power at the exit. 18-20 mW with energy density 21-28,8 j/cm2.

The method includes the use of led laser therapeutic apparatus "Grenade" ALOG-01, in continuous mode, using the nozzle-fiber diffuser 2 see For insufflation using the comfort dispenser for powdered photosensitizer into the cavity of the larynx special design, representing dubrovitsy laryngeal nozzle, pear with valve for air injection and a flask of powder. As a photosensitizer was applied the following medications: photosense, Halogens, methylene blue at a concentration of 0.5% and 1.0%. In all cases, the exposure of the photosensitizer was not less than 10 minutes, and the irradiation of the inflamed tissue in the cavity of the larynx is not less than 1.5 minutes. Conducting antimicrobial photodynamic therapy in power irradiation less than 18 mW is not effective, while values above 20 mW the effectiveness of therapy does not increase. The concentration of photosensitizers should also be no lower than 0.5% (below - ineffective) and not more than 1,0%when the efficiency is not increased.

The procedure was as follows: after opening the abscess in the larynx (abscess lingual surface of the epiglottis), or autopsy peritonsillar abscess (or accesscontrolentry) and the evacuation of the pus in the abscess cavity and the cavity of the larynx was applied powder starch-based or sorbitol containing the photosensitizer by the method of insufflation; the exposure time was 10 minutes. Then in the abscess cavity was installed fiber diffuser and carried out the irradiation of the inflamed areas of the larynx laser.

The following examples illustrate the invention.

Example 1.

The patient is., 56 years old, came with complaints of pain in the throat when swallowing, difficulty swallowing, fever up to 38°C after hypothermia. Specialized treatment is not received. History the patient was a year ago - abscess lingual surface of the epiglottis. Treated stationary, produced lancing of abscess of the epiglottis. As a result of the studies were diagnosed: "Flegmonoznih laryngitis. Abscess lingual surface of the epiglottis".

At admission was opened abscess lingual surface of the epiglottis under local anesthesia. Received 3 ml of purulent discharge. Was carried out by rinsing with an antiseptic solution. Half an hour after the opening of the abscess into the cavity of the abscess method insufflation put the powder on the basis of starch, containing the photosensitizer Halogens in a concentration of 0.5% for 10 minutes. Then the ball started photodynamic therapy laser therapeutic semiconductor "Grenade" endolaryngeal (2 minutes, 20 mW, the energy density 21.0 j/cm2).

The next day, the patient noted significant improvement in temperature is normalized. When indirect laryngoscopy revealed improvement: the entrance to the larynx is free. The epiglottis several hyperemia, mobile, on the lingual surface left - linear incisio, the wound edges with raids of fibrin. In abscess cavity about arozena hemorrhagic discharge. Then a second PDT session with the aforementioned method.

On the third day after admission to the ENT hospital complaints, the patient was absent. Noted improvement. When indirect laryngoscopy was noted moderate pastos of the epiglottis. The inflammation in the larynx is almost completely subsided. Conducted one session of PDT.

On the fourth day after receipt of inflammation in the larynx completely subsided in the clinical analysis of blood, there was normalization of laboratory parameters. The patient is prepared for discharge from the ear, nose and throat hospital for outpatient monitoring.

Example 2.

The patient Was 24 years old. Was admitted with complaints of pain in the throat when swallowing, difficulty in opening the mouth, increased body temperature to 38.0°C. according to the patient the above complaints concerned about 2 days after hypothermia; no specific treatment is not received. According to the results of the survey was diagnosed: "the Right of peritonsillar abscess. Chronic tonsillitis, TAF I". When entering ENT operation was performed - "opening of peritonsillar abscess right, received copious purulent discharge. On the same day was started a course of antimicrobial and anti-inflammatory photodynamic therapy, which are as follows: in the abscess cavity and on the right the velum amygdala is aesili powder starch-based, containing the photosensitizer methylene blue in a concentration of 0.5% by the method of insufflation. Exposure time was 10 minutes. Further, in the abscess cavity was installed fiber diffuser from the IR laser ALOG-01 "Grenades" with wavelength 0,685 μm. Conducted a session of antimicrobial photodynamic therapy: 4 minutes, the energy density of 25.2 j/cm2the capacity of 18 mW.

On the following day the patient noted improvement. Temperature is normalized. When inspecting the pharynx also showed improvement: the soft palate is slightly asymmetrical, the right soft palate tonsil beyond palatal arches, hyperemic, no raids. This was followed by the second session of antimicrobial photodynamic therapy for the specified method.

On the third day after beginning treatment, the patient had complaints of discomfort in the area of surgical intervention, weakness, noted improvement in General condition. When the examination of the throat pus from the abscess cavity was not received. Opening of the mouth was free, the right soft palate tonsil slightly pasty. Then was fulfilled the third session of antimicrobial PDT.

On the fourth day the patient had no complaints. When viewed from the soft palate was balanced. From the cavity of the abscess purulent discharge has been received. In the clinical analysis of blood - normalization of clinical and laboratory data. The patient was vypis is on ambulatory monitoring in the clinic at the place of residence.

Example 3.

Patient S., aged 26. Entered in the ENT Department with complaints of pain in the throat when swallowing, difficulty opening the mouth, fever up to 38.5°C for about 3 days, was treated independently, without lasting effect. Previously peritonsillar abscesses denied. The patient previously disturbed frequent sore throats. As a result of the research was diagnosed with "Left peritonsillar abscess, left parapharyngeal". On the day of receipt operation was performed - "left accesscontrolentry with revision parapharyngeal space, right tonsillectomy". Same-day course started PDT consisted of the following: fistula in parapharyngeal space method insufflation was put powder on the basis of starch, containing the photosensitizer photosense concentrations of 1.0%, also the photosensitizer was applied on the right and left mandlikova niches, applique was 10 minutes. Further, in preferencially fistula has entered the light guide diffuser from the IR laser ALOG-01 "Grenades" with wavelength 0,685 μm, for 4 minutes with the energy density of 28.4 j/cm220 mW.

On the following day after the start of antimicrobial photodynamic therapy the patient noted improvement, the temperature dropped to low values. When revision parapharyngeal space was obtained nathnac the positive purulent discharge. This was followed by the second session of antimicrobial photodynamic therapy on the above diagram.

On the third day the temperature is normalized. The patient noted complaints of discomfort in the area of surgical intervention, weakness. When revision parapharyngeal space purulent discharge was not received. Then there was held the third session of antimicrobial photodynamic therapy with the aforementioned method.

On the fourth day after surgery and the beginning of antimicrobial photodynamic therapy the patient noted significant improvement in General condition, complained of discomfort in the area of surgical intervention, weakness. Examination: the soft palate is symmetric, mandlikova free niches covered with fibrin. Purulent discharge was not received. Then spent the fourth session of antimicrobial photodynamic therapy on the above diagram.

On the fifth day of the complaints of the patient were not. Clinical and laboratory data were within normal limits. The patient was prepared for discharge from the ear, nose and throat hospital outpatient observation ENT doctor in the clinic at the place of residence.

Example 4.

Patient C., 24 years. Turned in the ENT Department with complaints of severe pain in the throat, radiating to the right ear, weakness, difficulty swallowing, fever up to 38.5°C. In the conversation with the patient found that the above complaints are even the slightest bit Bo is whether within 2 days after chilling and eating cold drinks. Specific treatment the patient received. After the examination the patient was diagnosed with "Follicular tonsillitis".

On the day of the examination, the patient began a course of antimicrobial photodynamic therapy consisted of the following: in the throat on the surface of the tonsils was done based powder sorbitol containing the photosensitizer methylene blue in 0.5%concentration, exposure time 10 minutes. Further, in the throat has entered the light guide diffuser from the IR laser ALOG-01 "Grenades" with wavelength 0,685 μm, for 2 minutes with the energy density of 23.4 j/cm2, with a capacity of 18 mW. On the following day the patient noted significant improvement, the sore throat is almost completely absent, the temperature of 37.1°C. When viewed hyperemia and swelling of the tonsils decreased significantly. Raids on tonsils were absent. Then was fulfilled the second session of antimicrobial photodynamic therapy in the above diagram.

On the third day after the start of treatment the patient had no complaints. Sore throat subsided. Clinical and laboratory data were normal. Clinical manifestations of angina was absent.

Thus, the proposed method provides: the introduction of a photosensitizer without cutaneous surgery, maintaining a constant concentration of the photosensitizer during the entire treatment session is, the exception is a more severe septic complications, reducing the frequency and volume of surgical procedures, reducing hospitalizations by accelerating the timing of inflammation and rehabilitation, effective PDT specified area. Also was awarded a reliable fixation of the photosensitizer on the basis of the powder in the cavity of the larynx for hours after the session is complete, antimicrobial photodynamic therapy.

1. Method of antimicrobial photodynamic therapy of acute inflammatory diseases of the hypopharynx or purulent complications, which consists in the introduction into the cavity of the laryngopharynx photosensitizer in the form of a powder starch-based or sorbitol containing photosensitizer 0.5 to 1.0% by the method of insufflation and subsequent irradiation of the laser wavelength 0,685 μm, with a capacity of 18-20 mW and energy density 21,0 for 28.8 j/cm2.

2. The method according to claim 1, wherein spend 2-5 sessions of photodynamic therapy.



 

Same patents:

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely otorhinolaryngology, phoniatrics and physiotherapy and may be used for the integrated treatment of aggravated chronic laryngitis. Starting from the 4-5th day from the aggravation, a standard drug therapy is additionally combined with an endolaryngeal injection of specific pyobacteriophague 1 ml and further exposure to low-frequency vibration covering 3 fields of the larynx and phonopaedic breathing exercises. The low-frequency vibration starts at a first filed comprising side neck surfaces at frequency 20 Hz per 1 filed with a vibratode advanced smoothly upward at 2-3 mm/sec with undisplaced skin and rectangularly up to a mandibular angle, and then downwards to a posterior triangle of neck for 1-2 minutes from each side; the patient does the phonopaedic breathing exercises and pronounces expiratory 'M'; that is followed by the vibrational exposure covering a projection of intersection of a thyroid cartilage plate and a border of sternocleidomastoid muscle (m.sternocleidomastoideus) at a thyroid cartilage notch at frequency 40 Hz and 60 Hz for 1-2 minutes from both sides according to the stable technique; the patient does the phonopaedic breathing exercises and pronounces expiratory vowels 'U', 'O', 'A'; that is followed by vibration of a collar at frequency 30-40 Hz with the vibratode advanced from a paravertebral line to a shoulder joint for 2-3 minutes from each side; the technique is labile. The course performs 8-10 combined daily procedures.

EFFECT: method enables higher clinical effectiveness ensured by the integrated effect on the patient's immune system in a combination with the drainage, anti-inflammatory, and trophic stimulating effects.

11 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, and aim at treating compensated non-specific chronic tonsillitis. A method involves a stress-protective therapy, a diet therapy, a vitamin therapy, a probiotic therapy, an antioxidant therapy, a therapy with prebiotic-like drugs, a local immunocorrecting and topical eradication therapy.

EFFECT: method is high effective in treating compensated non-specific chronic tonsillitis; it provides normalising an epigenetic regulation of gene expression and oxidation-reduction processes in the human body, creating conditions for relieving the micro-environmental disorder and recovering a colonisation resistance of the upper airway mucosa, an eradication of bacterial and viral infectious agents with underlying recovering an eubiosis of the upper airway mucosa, normalizing the gastrointestinal function, blocking the lipopolysaccharide effects of gram-negative bacteria, eliminating the aggravations within one year completely in the majority of patients.

9 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, namely to a method for preparing a therapeutic hydrogel material involving mixing an aqueous solution of sodium alginate and a drug preparation, dispersing a cross-linking agent that is presented by calcium sulphate in glycerol in the concentration of 0.8-2.5%, mixing the dispersion with the prepared mixture of sodium alginate with the drug preparation in ratio 1-2:4-6, placing the prepared product into a tiling pattern and keeping it till form-stable, conducting gamma sterilisation; the formation process involves the mechanical stability measurements with the diametral compression of the formed hydrogel; the hydrogel is considered to be formed once a thickness of the formed hydrogel varies with the diametral compression by 10-30%.

EFFECT: invention provides the wider medical variation of the drug concentrations, preparing high-thixotropy soft hydrogel materials (tablets) easy to administer, including through rectum, preparing the materials that preserve its all their physical-technical and mechanical properties after the gamma sterilisation along with the sterility.

4 cl, 10 ex

FIELD: veterinary.

SUBSTANCE: method involves the subcutaneous injections of donor animals' hyperimmune blood serum containing antihemagglutinin in titres to herpes virus-3 1:1280, to rednose virus - min. 1:256, to viral diarrhea -1:1024 and to adenovirus -1:128; in a dose of 2.0 ml/kg every 24 hours until recovered completely; besides, 20-30 minutes before feeding, a pytopreparation of 70% alcohol tincture of purple echinacea (Echinacea purpurea L) herb and blossom, common pine (Pinus sylvestris) buttons, horseheal (Inula helenium) roots and rhizomes, common licorice (Glycyrrhiza glabra L.) roots and harmala shrub (Peganum harmala) herb taken in relation 1:1:1:1:0.5 in the amount of 7-8% aqueous solution is administered in a dose of 3.0-3.5 ml/kg of body weight every 12 hours until recovered completely.

EFFECT: higher clinical effectiveness and natural body resistance.

4 tbl, 3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical industry and represents suitable for ingestion composition in form of particles for pain relief and reduction of inflammation in throat, which contains: a) at least one compound, selected from group, which consists of 2,4-dichlorobenzyl alcohol, amylmetacresol, cetylpyridinium chloride, hexidine, hexylresorcinol, flurbiprofen, lidocaine, benzocaine, ibuprofen, paracetamol, pectin, menthol and benzydamine; and b) bio-adhesive material in quantity to 10 wt %, and c) bicarbonate and/or organic acid, with particles having size less than 1 mm.

EFFECT: invention ensures necessary shearing force for effective expansion and complete hydration of carbopol with obtaining water dispersion for a short time, as well as forms gel with very high viscosity at low concentrations and has good property of film formation, which adds sensation of coating, perfect fluidity, suppression of dust and stability.

22 cl, 3 ex, 6 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, particularly to therapeutic preparations of mumiyo. The therapeutic preparation which contains purified mumiyo, grapefruit citrosept, edible glycerol, ethanol and water at specific proportions.

EFFECT: preparation has a prolonged shelf life.

8 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine and aims at treating acute and aggravated chronic laryngitis. What is involved is specific antibioticotherapy per os with additional examination of microflora starting from the 3rd-5th day of the therapy followed by instillations of specific, result-related bacteriophagues into the larynx in the amount of 0.5-1.0 ml in acute laryngitis for 7-10 days, and in aggravations for 10-14 days.

EFFECT: method provides higher clinical effectiveness ensured by a lower number of side effects and complications, and a reduced length of treatment.

16 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely otorhinolaryngology and may be used for treating chronic tonsillitis. That is ensured by ultrasound sanation of tonsils with the use of 0.05% chlorhexidine followed by Lugol's solution phonophoresis. The ultrasound sanation involves exposure on each tonsil for 60 seconds. The phonophoresis procedure involves contact exposure on each tonsil for 20 seconds. The therapeutic course is 10 daily procedures.

EFFECT: method provides microbiocoenosis recovery, anti-inflammatory action, reduced cicatricle changes in tonsil tissues, as well as mediated action on immunological processes.

2 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of biotechnology. Claimed is protein, including catalytic fragment of sialidase and possessing sialidase activity, which is selected from protein, whose sequence includes amino acids 274-666, or 274-681, or 290-666, or 290-681 SEQ ID NO:12, or includes amino acid sequence SEQ ID NO:14, described herein. Described is fused protein, which includes described above protein and anchor domain. Also given is information about molecules of nucleic acids, which code said proteins, expression vectors, containing said nucleic acids, and pharmaceutical compositions, containing said protein or fusion protein. Claimed is method of treatment or prevention of viral infection, caused by virus of influenza or parainfluenza, including application of therapeutically efficient amount of said composition to epithelial cells of subject.

EFFECT: invention makes it possible to extend arsenal of means against infection, caused by influenza or parainfluenza vitus.

25 cl, 2 tbl, 13 dwg, 17 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely balneology and balneotherapy, and concerns treating pharyngitis. That is ensured by gargarism with using hydrosulphuric mineral water of the Ust-Kachka resort of total mineralisation 76 g/dm3, hydrogen sulphide concentration 300 mg/dm3, at 18-20°C dissolved 1:5 to final concentration 50 mg/dm3, once a day, daily in the therapeutic course of 10-14 days.

EFFECT: method provides effective treatment of pharyngitis ensured by the high concentration of biologically active substances in mineral water.

3 ex

FIELD: medicine.

SUBSTANCE: method involves reflex therapy (RT) alternated with taking general baths every second day. The RT is conducted by inserting needles into corporeal points and microneedles into auricular points of the systemic effect on the 1, 5, 9, 13, 17, 21 procedures and executing the electric acupuncture of the paravertebral points on the 3, 7, 11, 15, 19 and 23 procedures. If the patients shows predominating psychoasthenic symptoms, iodine bromine baths are taken. The baths contains potassium iodide 50 mg/l and potassium bromide 125 mg/l. Water temperature is 36-37°C. If the vegetative imbalance predominates in the patients, radon baths with the radon concentration of 40-80 nCu/l are taken. Water temperature is 26-28°C. That is combined with the following laser therapy. The laser therapy is generated by Mlada apparatus. What is used is a continuous infrared light at wavelength 0.85 mcm, total output power of the two emitters 30 mWt. The patient is exposed by the standard procedure. The exposure covers 4 fields: a collar, an apex of heart, a middle one-third of chest and a left infrascapular region. The exposure length is 1 minute from 1st to 3rd procedure, 2 minutes from 4th to 6th procedures, and 3 minutes starting from the 7th procedure.

EFFECT: method improves the psychoemotional state of the patients thereby normalising the vegetative balance, and improves the working efficiency.

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to paediatrics, namely to otorhinolaryngology, and may be used in treating chronic tonsillitis in children's health centres, in-patient hospitals, polyclinics. The low-power laser light covers projections of palantine tonsils, namely an anterior lateral neck surface below a mandibular angle to the right and to the left. The laser light is generated at wavelength 0.89 mcm, constantly variable frequency 10 to 1,500 Hz by AZOR 2K-02 apparatus in the contact, stable mode. The exposure length is 1 minute per a field at pulse power 2-3 Wt/pulse daily; the therapeutic course is 7-8 procedures in 5-10-year-old children. The exposure takes 2 minutes per a field at pulse power 4-5 Wt/pulse daily within the therapeutic course making 9-10 procedures. Each physiotherapeutic procedure is preceded by tonsillar lacunae irrigation with sterile 0.9% normal saline using a Hartmann cannula. The method is safe by selecting laser light conditions in the children of various age groups.

EFFECT: method enables higher clinical effectiveness in chronic tonsillitis, prolonging remission, reducing a recurrence and complication rate, lowering the need for medical treatment, improving the quality of life in children and adolescents.

2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medical equipment, namely to prostate exposure apparatuses. The prostate exposure apparatus comprises a bevelled end hollow cylindrical body for the contact of its tip with an exposure area; the tip of the apparatus adjoins a laser source, a heating element, a temperature sensing element, an active electrode, and an indifferent electrode, an electronic unit, an inductor coil, and an ultrasonic assembly representing a piezoelectric radiator with an ultrasound concentrator in the form of a metal core that is an active electrode simultaneously; one end of the active electrode is led on the tip of the apparatus, while the other end is mechanically coupled with the piezoelectric radiator and connected to the electronic unit; the indifferent electrode also connected to the electronic unit is brought out of the body, while the inductor coil is configured so that the active electrode extends along an axis of symmetry; the piezoelectric radiator, targeted laser source, heating element, temperature sensing element and inductor coil are connected to the electronic unit.

EFFECT: due to the inductor coil and ultrasound emitter, the apparatus as compared to its prototype enables additional ultrasonic and magnetic field exposure on the prostate that improves the therapeutic effectiveness.

1 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely medicine, and may be used for treating urethral syndrome in females with using the antibacterial preparation gentamycin. Gentamycin is introduced into a urethral wall in the amount of 80 mg dissolved in anaesthetic solution 2 ml. The above preparation is introduced in parallel with the urethral wall. The anaesthetic is presented by 0.25% Novocaine. That is followed by a vulvar exposure to an infrared laser light at wave length 0.82 mcm, frequency 3000 Hz, and power 10 mWt. A procedure length makes 5-6 minutes; the therapeutic course is 8-10 procedures.

EFFECT: method is well tolerated, accessible and high effective by providing the high gentamycin concentration in the area of inflammation and stimulating repair processes.

1 ex, 2 tbl, 1 dwg

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, treating a cervical pathology associated with a high-oncogenicity human papilloma virus (HPV) infection. To eliminate the HPV for the purpose of the prevention of cervical cancer, a cervical mucosa is coated with a layer of a carbon dye and exposed to a laser light. What is used is a pulse-periodic generation mode having the following parameters: power flow density 2-10 J/cm2, radiation pulse duration 10-4 -10-2 sec, pulse repetition rate 1-5 Hz, wave length 0.8-1.1 mcm. A device for implementing the method comprises a laser working in the above mode with the above parameters, a modulator, a control and indication unit for laser parameter setting by the modulator, a parameter measurement unit for laser control, a controlled microinjector, a carbon dye delivery and radiation system actuated by the controlled microinjector, a probing laser for controlling the carbon dye layer thickness.

EFFECT: group of inventions provides eliminating the HPV from the cervical surface, controlling the thermal exposure area, its safety with avoiding an uncontrolled, irreversible injury of the cervical surface and the uterine itself.

8 cl, 1 dwg, 5 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, particularly to ophthalmology. What is involved is a brachytherapy of an intraocular melanoma with a size of more than 6.5 mm by anchoring a beta-applicator with ruthenium-106 +rhodium-106 to an episclera for 7-14 days on a projection of the melanoma at total radiation dosage 3000 Gy. The brachytherapy is combined with a diode-laser transpupillar therapy of the melanoma at radiation power 800 mWt. Then, 6-12 months after the beta-applicator has been removed, a restrictive retinal coagulation at power 500 mWt and an endoresection of the residual melanoma follow. The method enables avoiding such complications, as vitreous body and retina haemorrhage, retinal detachment, complete loss of vision, as well as reducing a probability of metastases due to the preliminary brachytherapy and the following restrictive retinal laser coagulation.

EFFECT: combined application of the thermal therapy and brachytherapy enables affecting the melanoma from both sides for more complete destruction of its structure.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely gynaecology, physiotherapy. A method involves the integrated treatment of the patients with genital endometriosis and hysteromyoma. The treatment involves taking mineral water, observing a biologically programmed light pattern, taking radon baths and radon gynaecological irrigations and small enemas, as well as conducting a laser therapy of biologically active points (BAPs). The patients take carbonated chloride-hydrocarbonate-sulphate sodium-calcium warm Narzan water taken from sources No. 4, No. 7 and No. 24, 3.4 mg per kg 3 times ad day, 40 minutes before meals. The radon baths are taken with the radon concentration of 1.5 kBq/l. The radon gynaecological irrigations and microenemas are performed with the radon concentration of 6.5 kBq/l, temperature 36°C, for 15 minutes within the course of 10-12 procedures. The BAP laser therapy is conducted in an autoresonant mode. The BAPs of anterior median meridian are covered, including: 1-2 (qu-gu), 1-3 (zhong-ji), 1-4 (guan-yuan), 1-5 (shi-men), 1-7 (yin-jiao); renal meridian: R-12 (da-ho), R-13 (qi-xu), R-14 (si-man), R-15 (zhong-zhu), R-16 (huang-shu); bladder meridian: V-31 (shang-liao), V-32 (ci-liao), V-33 (zhong-liao), V-34 (xia-liao); posterior median meridian: T-2 (yao-shu), T-3 (yao-yang-guan), T-4 (min-man), T-5 (xuan-shu). Using the radon baths of the different radon concentrations 'softens' an effect of the absorbed radiation dose on the homeostasis systems and preserves an effect of a high absorbed dose on the genital system. The laser therapy in the autoresonant mode within pathological BAPs improves the accuracy of the exposure on the pathological processes within a target organs.

EFFECT: method prolongs the remission, normalises the hormonal ratios in the remote period.

2 dwg, 4 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, particularly to ophthalmology. That is ensured by the integrated treatment involving the single macular exposure to a sublimit micro-pulse infrared laser light. That is combined with the ozone therapy using drug preparations with underlying mixed gas agitation. That is followed by an antioxidant therapy consisting of local instillations of emixipin and oral administration of complivit oftalmo.

EFFECT: method enables the therapy of predisciform age-related macular degeneration at the stage of confluent drusens, preventing the development of the disease and improving the visual acuity.

2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to surgery, and may be used in treating trophic ulcers and infected persistent wounds. That is ensured by the exposure to an argon plasma flow in a dose of 100-250 J/cm2 at 10-25 cm from the treated surface. The exposure length on one field makes 10-25 seconds. The sound surface treatment is followed by the dynamic exposure to a running argon plasma flow at 10-20 cm in a dose of 80-150 J/cm2 over the whole wound surface to form a gloss on the wound surface.

EFFECT: method provides the effective treatment of the given pathology ensured by specifying a mode of the exposure causing the microorganism elimination, wound surface drying, sudden perifocal oedema reduction, as well as epithelial cell growth stimulation on the periphery of the wound, as well as on its free surface.

3 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine. A method of treating the patients with the complicated forms of diabetic foot by blood sampling, centrifugation, plasma removal, erythrocyte fraction recovery, introduction of the angiotropic drug alprostadil, exposure to laser light at power 12 mWt for 20 minutes, addition of normal saline 100 ml in erythrocyte fraction 200 ml and reinfusion for 1.5-2 hours; ATP 2 ml is combined with the angiotropic drug alprostadil and introduced into the erythrocyte fraction; the erythrocyte fraction is reinfused every second day, alternated with intravenous drop-by-drop introduction of Vessel-DUE-F 600 LSU and actovegin 5 ml per normal saline 100 ml; the therapeutic course is 10 days.

EFFECT: using the method provides higher effectiveness and reduces the length of treatment of the patients with the complicated forms of diabetic foot syndrome, promotes the longer preservation of the achieved therapeutic effect.

FIELD: medicine.

SUBSTANCE: invention relates to medical equipment, namely to device for supply of ozone or mixture ozone/oxygen in dosed quantities for intraperitoneal introduction in animal or human body, as well as applied fittings for it. Device contains source of flowing medium or means for connection with source of flowing medium and dosing output. Device also contains built in line of flowing medium regulator of mass consumption, whose input is functionally connected with shutoff-discharge element or is made in form of such element. Dosing output is functionally connected with shutoff-discharge element of supply. It also contains electronic system of control, equipped and/or configured at the level of software and/or hardware means of control. Fittings are intended for connection with device dosing output by line of flowing medium supply, which has two ends. Fittings contain shutoff-discharge element of supply, which is built into second connective device, and bacterial filter, which is placed inside body of first connective device. Bacterial filter is made in form of membrane from ozone-resistant material.

EFFECT: application of invention improves accuracy of ozone dosing.

24 cl, 8 dwg

Up!