Method for integrated treatment of pathozoospermia in males suffering adrenal hyperandrogenism
SUBSTANCE: invention refers to medicine, namely urology, andrology and endocrinology, and may be used for the integrated treatment of pathozoospermia in males suffering adrenal hyperandrogenism. For this purpose, dexamethasone 0.5 mg is administered additionally twice a day for 8 weeks with underlying standard regimen. Besides, the blood is UV-radiated 3 times a week for 15 minutes; the therapeutic course is 12 procedures.
EFFECT: method provides normalising spermatogenesis ensured by improved microcirculation, anti-inflammatory, immunopotentiating, antioxidant effects, as well as high repair activity with no side effects and substantial contraindications to the treatment.
2 tbl, 2 ex
The invention relates to medicine, in particular to urology and endocrinology, and can be used in the treatment of photosphere in men with adrenal hyperandrogenism.
This problem has not only medical but also social, including demographic value. Infertility neuroendocrine origin, according to the world health organization, 35-40% of all cases of infertility). Infertility in men is the inability to fertilize the egg due to erectile dysfunction, ejaculation or spermatogenesis. Causes of male infertility can be pathological processes in the body, leading to degenerative changes in the seminiferous tubules and interstitial tissue of the testes, impaired secretion of sex hormones and photosphere. Androgen is a male sex hormones, which are produced by the testes in men and ovaries in women. Biological effects of androgens are more pronounced in the male body, these hormones enable the development and formation of the organs of the male reproductive system and its regulation. Androgens affect the development of secondary sexual characteristics and also regulate the growth and development of male sex organs. They affect metabolic processes, causing the so-called anabolic effect - stimulating effect on protein synthesis in the body (Deniso the BP, Sakevich VI "on reproductive health". J. "Sociological studies". M., 2004, No.1, p.75-85. The gromenko DS."pathogenesis of idiopathic photosphere in male infertility". Abstract. of thesis ... Dr. med. Sciences: 14.00.16. SPb., 2009, p.17-19).
Cause of giperandrogenii may be diffuse hyperplasia of the adrenal cortex, increases significantly and the amount of hormones produced. When the amplification function of the adrenal glands (sensual stress, the onset of sexual activity, pregnancy) impaired synthesis of steroids in the direction of giperandrogenii, which in turn inhibits the secretion of gonadotropins and disrupts the testicles (Kulakov V.I. "Barren marriage." M., "GEOTAR-Media", 2005, s-219).
All the above indicates the need to expand treatment capabilities of photosphere in men with adrenal hyperandrogenism.
Glucocorticoid hormone (dexamethasone) is a synthetic glucocorticosteroid (GCS) is a methylated derivative of forpension. Anti-inflammatory,
desensitizing, immunosuppressive, anti-toxic effect, increases the sensitivity of beta-adrenergic receptors to endogenous catecholamines. Interacts with specific cytoplasmic receptors with the formation of the complex, inducing the formation of proteins. The principle of action is via GCS suppress the allocation of ACTH (adrenocorticotropic hormone) is used in acute insufficiency of the adrenal cortex, primary or secondary failure of the adrenal congenital hyperplasia of the adrenal cortex in men with adrenal hyperandrogenism and photosphere, to normalize gormonalnogo background and indicators of spermatogenesis (Kulakov V.I., Serov V.N., L.V. Adamyan "guidelines for reproductive health". M., "GEOTAR-Media", 2001, p.24-27).
UFOC holds a special place in the treatment of male infertility, enhances the production of sperm, increases their mobility, has an antioxidant effect and prevents lipid peroxidation
UFOC has antibacterial, antiviral effect, improves microcirculation hormone producing organs, improves their quality of sperm production, stimulates cellular and humoral immune system, has anti-allergic effect, normalizes the gas composition of the blood, reduces blood viscosity, preventing thrombus formation, potentiates the effect of an administered drug (Artsishevskiy R.A. and other Functional changes on the surface of human erythrocytes in norm and pathology after exposure to UV radiation of different spectral composition". Sat. scient. Tr. edited Yeganian, Casamilano. "Mechanisms of influence irradiated with ultraviolet rays of blood on the body of humans and animals". Leningrad, "Nauka", 1986, s-226).
Known SPO is about the treatment of autoimmune infertility in men to reduce titers of antisperm antibodies in the blood of a patient includes a peripheral intravenous ultraviolet blood irradiation of the patient apparatus HVAC-3-(04), apply a continuous membrane plasmapheresis (Patent of Russia, having got No. 21 85 211, A61N 5/7, "a Method for the treatment of autoimmune infertility in men", 20.07.2002,, B. I. No. 21, 2002).
The disadvantage of this method is that this way it is possible to treat men only with autoimmune infertility and an increased titer of anti-sperm antibodies.
Our research proved that the application of dexamethasone, ultraviolet irradiation of blood for the treatment of photosphere in men with adrenal hyperandrogenism is: normalization of hormonal levels, increased sperm production and increase their mobility, improvement of spermatogenesis in the direction of increasing activepageindex sperm and, consequently, increase the chances of pregnancy in women.
When conducting a patent search, the use of dexamethasone, ultraviolet irradiation of blood for the treatment of photosphere in men with adrenal giperandrogenii was not found.
Object of the invention is enhanced treatment photosphere men adrenal hyperandrogenism due to the use of dexamethasone, ultraviolet irradiation of blood.
This task is achieved by the method of complex treatment of photosphere in men with adrenal hyperandrogenism against the standard treatment regimens and different is the present, further, for the normalization of a hormonal background, applies dexamethasone 0.5 mg 2 times a day for 8 weeks, to increase sperm production and improve their mobility, is carried out by ultraviolet irradiation of blood 3 times a week for 15 minutes number 12 procedures.
Efficacy of dexamethasone, ultraviolet irradiation of blood for the treatment of photosphere in men with adrenal hyperandrogenism shown in the following examples.
The patient Was 33 years. Diagnosis: Infertility 1. Adrenal hyperandrogenism. Was on routine examination and treatment in the Department of endocrinology NTS PTSRC WITH the RAMS with 16.01.12 on 27.01.12, outpatient treatment for up to 6 weeks.
Complaints: in the presence of infertility in marriage, for 5 years.
Table 1 shows the test results of the patient,
|Indicators||When receiving||After 8 weeks||standards|
|OAK (complete blood count)||Er of 4.7*1018||a 4.9||of 3.9 to 5.0*1018l|
|Hemoglobin 160||155||120-160 g/l|
|p/I of neutrons 3||2||0-4|
|C/I of neutrons 71||70||50-70|
|Mono/C 5||4||Up to 6|
|Eosinophils 1||1||Up to 3|
|OAM (urinalysis)||The inheritance. weight 1012||1018||1007-1020|
|1-2 O.S.||0-3 O.S.|
|Lei/kg 2-3 O.S.||ed O.S.||1-3 O.S.|
|Biochemical analysis of blood||Alt,0||19,3||To 41 u/l|
|Bilirubin is 9.2||8,9||To 20.5 μm/l|
|Sugar is 4.9||5,2||3,3-6.4 mmol/l|
|Cholesterol 5,0||a 4.9||To 5.2 mmol/l|
|DOG 0,04||0,05||0.3 to 4.0 ng/ml|
|Ultrasound of the prostate t/rectal||V=20,0||V=19,9||To 21.0 ml|
|The body mass index||22,0||22,0||25-30 kg/m2|
|Sperm category a||3||28||25%|
|Antisperm antibodies||A negative.||A negative.||Neg.|
|Lyuteiniziruyuschy hormone (LH)||4,1||4,0||0,8-8,4 mIU/ml|
|Folliculitis is stimulating hormone (FSH)||9,8||7,0||1,0-11,8 mIU/ml|
|Testosterone||38,0||28,0||the 12.1-38,3 nm/l|
|17 oksiprogesterona (17-SNPS)||8,3||2,2||2.0 to 6.5 nmol/l|
Treatment: dexamethasone, the optimal time of admission 8 and 16 hours a day. The dose is determined under the control of dehydroepiandrosterone, testosterone, 17-Oh-progesterone concentrations in patients receiving dexamethasone should not exceed the upper limit of normal, in this case the patient,,, dexamethasone appointed in a dose of 0.5 mg 2 times day, a course of 8 weeks and ultraviolet irradiation of blood 3 times a week, for 15 minutes, number 12 procedures. Were additionally assigned polivet the ins containing potassium iodide at least 150 μg, protective mode.
On the background of this therapy, the patient reported a significant improvement in overall health, normalization of hormonal levels, a decrease in the concentration of testosterone, reducing the concentration in the serum dehydroepiandrosterone, testosterone, 17 - Oh-progesterone and as a consequence of the above changes the normalization of indicators of spermatogenesis, increased sperm production and an increase in the concentration activepageindex sperm involved in fertilization.
For comparison here is the results of treatment of the patient, without the use of dexamethasone conducted using ultraviolet irradiation of blood and standardised treatment of the underlying disease.
Patient I., 31. Diagnosis: Infertility 1. Adrenal hyperandrogenism. Was on routine examination and treatment in the Department of endocrinology NTS PTSRC WITH the RAMS with 16.01.12 on 27.01.12, outpatient treatment for up to 6 weeks
Complaint: on infertility in marriage 2 years.
Table 2 shows the results of analyses of patient I.
|OAK (complete blood count)||Er 4,2||4,4||3,9-5,0|
|Hemoglobin 149||146||120-160 g/l|
|p/I of neutrons 3||2||0-4|
|C/I of neutrons 72||72||50-70|
|the it/C 2||2||Up to 6|
|Eosinophils 2||1||Up to 3|
|OAM (urinalysis)||The inheritance. weight 1021||1013||1007-1020|
|Epic 1-2 O.S.||ed O.S.||0-3 O.S.|
|Lei/kg 2-3 O.S.||ed O.S.||1-3 O.S.|
|Biochemical analysis of blood||Alt 25,3||22,3||To E/l|
|AST 26,3||26,3||Up to 40 u/l|
|Bilirubin 9,0||12,4||To 20.5 μm/l|
|Sugar 4,5||5,6||3,3-6.4 mmol/l|
|Cholesterol of 5.2||a 4.9||To 5.2 mmol/l|
|DOG 0,9||1,0||0.3 to 4.0 ng/ml|
|Ultrasound of the prostate t/rectal||V=19,l||V=20,0||To 21.0 cm3|
|Sperm category a||5||9||25%|
|Antisperm antibodies||A negative.||A negative.||Neg.|
|Lyuteiniziruyuschy hormone (LH)||3,1||2,7||0,8-8,4 mIU/ml|
|Follicle-stimulating hormone (FSH)||8,9||the 9.7||1,0-11,8 mIU/ml|
|Testosterone||25,0||27,3||the 12.1-38,3 nm/l|
|17 oksiprogesterona (17-SNPS)||8,3||8,1||2.0 to 6.5 is mol/l|
|Dehydroepiandrosterone (DHEA)||11,2||11,0||2,6-10,92 µmol/l|
For treatment were assigned a multivitamin containing potassium iodide at least 150 μg, ultraviolet irradiation of blood 3 times a week, for 15 minutes, number 12 procedures, protective mode.
On the background of this therapy in a patient, visible improvements indicators of spermatogenesis and hormonal did not happen.
A comprehensive treatment of dexamethasone, ultraviolet irradiation of blood was studied in 15 patients with a diagnosis of Infertility 1. Adrenal hyperandrogenism.
In all cases, the normalization of indicators of spermatogenesis was observed significantly faster and remained for a long time, more cycle of spermatogenesis (on average more than 72 days)than without receiving offer comprehensive treatment.
The proposed method of complex treatment of photosphere in men with adrenal hyperandrogenism with the use of dexamethasone to normalize hormonal levels, enhance sperm production and improve sperm motility; ultraviolet blood irradiation is carried out to improve sperm production, stimulates the growth of seminiferous tubules, the fact itself is m providing the sperm maturation process, reduces the time of treatment, is not required for hospital stay (subject to availability HVAC-03 may at polyclinics). This method of complex treatment of photosphere in men with adrenal hyperandrogenism lengthens the duration of viability of sperm and activity of sperm production, increases concentration activepageindex sperm involved in fertilization, has no harmful side effects on the body and has no significant contraindications.
This method of complex treatment of photosphere in men with adrenal hyperandrogenism has a high incentive opportunities spermatogenesis, anti-inflammatory, immunostimulant, antioxidant, and also has a high regenerative activity in men with infertility, adrenal giperandrogenii normalization of spermatogenesis in the direction of increasing activepageindex sperm, and as a consequence increase the chances of pregnancy in women, improves endocrine organs, contributing to their recovery by improving microcirculation, which causes therapeutic effect and allows to expand the range of therapeutic actions. Recommended as the method of complex treatment what s photosphere in men with adrenal hyperandrogenism.
The method of complex treatment of photosphere in men with adrenal hyperandrogenism against the standard regimens, characterized in that it additionally applies dexamethasone 0.5 mg 2 times a day for 8 weeks and is carried out by ultraviolet irradiation of blood 3 times a week for 15 minutes number of 12 treatments.
SUBSTANCE: what is presented is medium and method for the vital immobilisation of human and animal sperm cells, wherein the sperm cells of native or thawed sperm prepared by the ejaculate centrifugation in a density gradient, or sampled by the flotation; the sperm cells are transferred into an immobilisation medium with low osmotic pressure 100-170 mOsm/kg for 1 min to 2 hours with the gas mixture composition containing 0.1 to 8% of carbon dioxide, and a medium temperature of 0 to 39°C.
EFFECT: invention may be used for diagnostic and therapeutic purposes for animal reproduction and fertilisation.
7 cl, 1 tbl
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to 5,6-dihydropyrrolo[2,1-a]isoquinoline and pyrrolo[2,1-a]isoquinoline derivatives of general formula (I): or a pharmaceutically acceptable salt thereof, wherein C5-C6-bond may be either saturated, or unsaturated; the values R1; R2; R3 ; R7 ; R8; R9; R10 are presented in cl.1 of the patent claim.
EFFECT: compounds may be used for treating infertility.
24 cl, 124 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biotechnology, more specifically, to using a chimeric somatostatin-containing protein for improving the reproductive properties of male farm animals and cocks, and may be used in veterinary science. The injection preparation is used in the form of a chimeric protein suspension with water-insoluble enzyme-inactive chloramphenicol acetyltransferase with no 10 C-terminal amino acids, amino acid spacer (Sp)n, wherein n=1, 2, 4, 8 and somatostatin-14 with AGCFWKTFTSC amino acid sequence in the refined vegetable oil with bee wax added at 250-1000 mg of the above chimeric protein per 100 ml of the refined vegetable oil containing 0.9-1.1 wt % of bee wax. The injection preparation is used in cocks and farm animals after achieving the physiological maturity at 50-200 mcg of the protein per 1 kg of a live body weight.
EFFECT: invention enables increasing sperm production: increasing the ejaculate volume and reducing the biologically damaged sperm in farm animals and cocks by using the preparation for injections with a low-reactogenicity adjuvant.
2 cl, 13 tbl
FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions refers to medicine, pharmacology, to methods and PTEN phosphatase inhibitor compositions for ovarian follicle and oocyte development in vitro. Using the PTEN phosphatase inhibitors, such as complexes of oxovanadate and peroxovanadate: bisperoxo (bipyridine) oxovanadate, bisperoxo (1,10-phenanthroline) oxovanadate, bisperoxo (picolinato) oxovanadate, bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate, di- (picolinat) oxovanadate, di-(3-hydroxypicolinat) oxovanadate, bisperoxo (phenylbiguanide) oxovanadate, di-(phenylbiguanide) oxovanadate and bisperoxo (isoquinoline carboxylic acid) oxovanadate, provide the development and activation in vitro of oocytes and follicles, such as primordial, intermediate and primary ovarian follicles.
EFFECT: invention provides the development and activation in vitro of oocytes and follicles, such as primordial, intermediate and primary ovarian follicles.
14 cl, 3 dwg, 2 ex
SUBSTANCE: invention refers to medicine, namely andrology, as well as may be used in veterinary science for treating mammals suffering disturbed fertility. An agent for improving the reproductive function represents a clathrate complex of γ-cyclodextrin and arabinogalactan, or glycyrrhetinic acid with 9-phenyl-symmetrical octahydroselenoxantene in the α-crystalline form and is described by structural with Cu-K emitted X-ray powder pattern having characteristic reflections expressed in degrees of diffraction angle 2θ: 6.0 12.0 15.0 17.0 19.0 20.0 21.5, 21.7, 20.9 25.0 27.0 28.0 29.0 37.0 and a melting point of 96.8°C.
EFFECT: improved pregnancy and fertility rates.
18 tbl, 5 ex
SUBSTANCE: invention refers to medicine, namely andrology, as well as may be used in veterinary science for treating mammals suffering disturbed fertility. An agent for improving the reproductive function represents a clathrate complex of β-cyclodextrin and 9-phenyl-symmetrical octahydroselenoxantene in the α-crystalline form and is described by structural formula with Cu-K emitted X-ray powder pattern having characteristic reflections expressed in degrees of diffraction angle 2θ: 6.0 12.0 15.0 17.0 19.0 20.0 21.5, 21.7, 20.9 25.0 27.0 28.0 29.0 37.0 and a melting point of 96.8°C.
EFFECT: invention provides higher pregnancy and fertility rates.
6 tbl, 1 ex
SUBSTANCE: invention refers to medicine, namely oncology, and may be used for the drug-free correction of the drug-free correction of idiopathic asthenozoospermia. For this purpose, every second day medicinal leeches are used 4 times for each point of alternating zones: 4 point in the pubes: in the midline above the pubic bone at the base of the penis and 2 parallel points at the intersection of a lateral line of the abdomen and the pubic bone from both sides; in the perianal area - 4 points corresponding to III, VI, IX and XII o'clock of the perianal area at 1-2 cm from the pigmentation area; in the sacral area - 4 points located on a projection angle of the sacrum, and in the coccygeal area - 4 points corresponding to a projection of the coccyx; the therapeutic course is 2-3 weeks.
EFFECT: method enables increasing the fertility ensured by the significant improvement of sperm kinesiogram.
SUBSTANCE: invention refers to medicine, namely to urology and endocrinology, and may be used in the integrated treatment of male normogonadotropic infertility. For this purpose, the conventional therapeutic regimens are added with administration of follitropin alpha (gopal-f) subcutaneously three times a week, 150 IU for 6 weeks. In addition, blood is exposed to UV irradiation for 20 minutes, 2 times a week; the therapeutic course is 12 procedures.
EFFECT: method provides anti-inflammatory and immune stimulating action, as well as ensures the effective treatment ensured by the high stimulating capacity of spermatogenesis, improves endocrine organs promoting their recovery by improving microcirculation that causes the therapeutic effect and extends the range of therapeutic activities with reduced the length of treatment and requires no staying in hospital.
2 ex, 2 tbl
SUBSTANCE: invention refers to medicine, particularly to molecular physiology and biochemistry, and may be used for normalizing spermatogenesis in animals in chronic natural gas poisoning. The method for spermatogenesis correction in animals suffered chronic natural gas poisoning, consisting in the use of selenium-containing preparations, and a correcting preparation is Selexen used in a combination with ascorbic acid administered orally to male albino rats in doses of 1.5 mg/kg and 500 mg/kg of animal's body weight, respectively once a day for 50 days, and at the same time from the third week of the administration of Selexen and ascorbic acid, the animals are exposed to sulphurous natural gas in the concentrations of 10 mg/m3 for 30 days, 240 minutes a day, and upon the completion of the experimental exposure, the morphological and kinetic parameters of spermatogenesis are to be examined.
EFFECT: implemented reduction of the toxic effects of natural gas on the reproductive function of male gonads.
1 tbl, 3 ex
SUBSTANCE: invention relates to field of medicine and is intended for treatment of menstrual cycle irregularities in teenage girls with obesity. Method includes administration of siophor 5-10 minutes after meal for 10 days in the morning, in the afternoon and in the evening in dose 250.0 mg, from the 11-th day in the morning and afternoon in dose 250.0 mg, in the evening 500.0 mg for 10 days, from the 21-st day in the morning, afternoon and evening in dose 500.0 mg, in case of good tolerance from the 31-st day in the morning and afternoon - 500.0 mg, in the evening - 750.0 mg, for 6 months. Microacupuncture is performed in acupuncture points (AT): AP(X)55, AP(II)17, AP(II)18, AP(IV)22, AP(VI)28, AP(XIV)87, AP(XVI)100, influence is performed in time interval 10-13 hours, in the first two days influence id performed on AT AP(II)17, AP(II)18 on the right and left, on the 3-5-th days influence is performed on AT AP(X)55 on the left, and AT AP(II)17, AP(II)18, AT AP(IV)22 on the right, on the 6-10-th days AP(XVI)100 on the left, AT AP(II)17, AP(II)18, AP(VI)28, AP(XIV)87 on the right. Introduced microneedles are adhered with adhesive plaster. Patient periodically presses on them for 1 min when they feel sense of hunger. Course treatment with microacupuncture consists of 10 procedures. Microacupuncture treatment course is carried out 2 times per year.
EFFECT: invention increases treatment efficiency, makes it possible to prolong clinical remission.
SUBSTANCE: invention relates to medicine, namely ophthalmology. The method involves a transepithelial corneal collagen crosslinking. That is preceded with a single bath electrophoresis with 1% riboflavin mononucleotide. That is ensured by an initial current of 0.2 mA to be increased gradually to 1 mA, at a pitch of 0.2 mA for 2 minutes. That is followed by an ultraviolet corneal exposure. The exposure is conducted at wave length 370 nm, power 3 mWt/cm2 and combined with instillation of a riboflavin solution. The solution contains 0.1% riboflavin mononucleotide and 20% dextran.
EFFECT: method provides more effective riboflavin delivery to the corneal stroma for one procedure providing the intraocular protection against ultraviolet light.
2 cl, 1 ex
SUBSTANCE: invention refers to medical equipment, namely to prostate exposure apparatuses. The prostate exposure apparatus comprises a bevelled end hollow cylindrical body for the contact of its tip with an exposure area; the tip of the apparatus adjoins a laser source, a heating element, a temperature sensing element, an active electrode, and an indifferent electrode, an electronic unit, an inductor coil, and an ultrasonic assembly representing a piezoelectric radiator with an ultrasound concentrator in the form of a metal core that is an active electrode simultaneously; one end of the active electrode is led on the tip of the apparatus, while the other end is mechanically coupled with the piezoelectric radiator and connected to the electronic unit; the indifferent electrode also connected to the electronic unit is brought out of the body, while the inductor coil is configured so that the active electrode extends along an axis of symmetry; the piezoelectric radiator, targeted laser source, heating element, temperature sensing element and inductor coil are connected to the electronic unit.
EFFECT: due to the inductor coil and ultrasound emitter, the apparatus as compared to its prototype enables additional ultrasonic and magnetic field exposure on the prostate that improves the therapeutic effectiveness.
SUBSTANCE: invention refers to medicine, namely medicine, and may be used for treating urethral syndrome in females with using the antibacterial preparation gentamycin. Gentamycin is introduced into a urethral wall in the amount of 80 mg dissolved in anaesthetic solution 2 ml. The above preparation is introduced in parallel with the urethral wall. The anaesthetic is presented by 0.25% Novocaine. That is followed by a vulvar exposure to an infrared laser light at wave length 0.82 mcm, frequency 3000 Hz, and power 10 mWt. A procedure length makes 5-6 minutes; the therapeutic course is 8-10 procedures.
EFFECT: method is well tolerated, accessible and high effective by providing the high gentamycin concentration in the area of inflammation and stimulating repair processes.
1 ex, 2 tbl, 1 dwg
SUBSTANCE: invention refers to medicine, namely transplantology, and can be used for prevention and treatment of a renal graft rejection. That is ensured by an extracorporeal photophoresis by administering a photosentiser, recovery of a mononuclear cell concentrate, dilution in normal saline and suspension exposure to ultraviolet light Additionally, the ultraviolet exposure is followed by normal saline substitution by blood plasma in the same amount. Then, the prepared mixture is added with cytokine, granulocyte-macrophage colony-stimulating factor in a dose of 80-120 ng/ml. Thereafter, the prepared composition is incubated for 90-120 minutes. Then, plasma with cytokine is substituted by normal saline in the same amount, and the prepared suspension is then injected back into blood channels. A first photophoresis session is performed on the 3rd-4th day following the renal transplantation. The first two weeks provide performing two sessions a week. For the next six weeks, one session a week is performed. For the following third month, two sessions are performed. That is followed by one session a month for the fourth, fifth and sixth months. The therapeutic course makes 15 sessions.
EFFECT: method enables reducing a rate of acute renal graft rejections considerably ensured by improving a graft function, increasing its survival and life ensured by achieving an evident immunological specific tolerance to graft alloantigens, namely as a result of providing the higher tolerogenic properties of the prepared dendritic cells by the performed translation cell therapy.
SUBSTANCE: group of inventions refers to medicine, treating a cervical pathology associated with a high-oncogenicity human papilloma virus (HPV) infection. To eliminate the HPV for the purpose of the prevention of cervical cancer, a cervical mucosa is coated with a layer of a carbon dye and exposed to a laser light. What is used is a pulse-periodic generation mode having the following parameters: power flow density 2-10 J/cm2, radiation pulse duration 10-4 -10-2 sec, pulse repetition rate 1-5 Hz, wave length 0.8-1.1 mcm. A device for implementing the method comprises a laser working in the above mode with the above parameters, a modulator, a control and indication unit for laser parameter setting by the modulator, a parameter measurement unit for laser control, a controlled microinjector, a carbon dye delivery and radiation system actuated by the controlled microinjector, a probing laser for controlling the carbon dye layer thickness.
EFFECT: group of inventions provides eliminating the HPV from the cervical surface, controlling the thermal exposure area, its safety with avoiding an uncontrolled, irreversible injury of the cervical surface and the uterine itself.
8 cl, 1 dwg, 5 ex
SUBSTANCE: invention refers to device for irradiating a person's body of a person with actinic radiation. The device comprises a means allowing the person to stand on a stand, sit on a seat or lie on a bed in a radiation position; a means allowing a control of the intensity, irradiance, dose, and/or time of irradiation of said actinic radiation to be irradiated and/or irradiated onto the above person's body, a means comprising a radiation source with at least one of wavelengths being found in the visible range, and at least the other of wavelengths being found within the invisible range. The actinic radiation of at least one wavelength is radiated within the broadband from the near ultraviolet band, through the visible range to the near infrared region, and is reflected by a reflector coated on its concave side towards the user. The device comprises a filter provides the actinic radiation transmission of at least one specific band of wavelengths within 570-780 nm and/or within 810-850 nm.
EFFECT: using the invention provides an effective dose of radiation with using a combination of the narrow bands of wavelengths.
14 cl, 6 dwg
SUBSTANCE: invention relates to medicine, particularly to ophthalmology. What is involved is a brachytherapy of an intraocular melanoma with a size of more than 6.5 mm by anchoring a beta-applicator with ruthenium-106 +rhodium-106 to an episclera for 7-14 days on a projection of the melanoma at total radiation dosage 3000 Gy. The brachytherapy is combined with a diode-laser transpupillar therapy of the melanoma at radiation power 800 mWt. Then, 6-12 months after the beta-applicator has been removed, a restrictive retinal coagulation at power 500 mWt and an endoresection of the residual melanoma follow. The method enables avoiding such complications, as vitreous body and retina haemorrhage, retinal detachment, complete loss of vision, as well as reducing a probability of metastases due to the preliminary brachytherapy and the following restrictive retinal laser coagulation.
EFFECT: combined application of the thermal therapy and brachytherapy enables affecting the melanoma from both sides for more complete destruction of its structure.
SUBSTANCE: invention refers to medicine, namely gynaecology, physiotherapy. A method involves the integrated treatment of the patients with genital endometriosis and hysteromyoma. The treatment involves taking mineral water, observing a biologically programmed light pattern, taking radon baths and radon gynaecological irrigations and small enemas, as well as conducting a laser therapy of biologically active points (BAPs). The patients take carbonated chloride-hydrocarbonate-sulphate sodium-calcium warm Narzan water taken from sources No. 4, No. 7 and No. 24, 3.4 mg per kg 3 times ad day, 40 minutes before meals. The radon baths are taken with the radon concentration of 1.5 kBq/l. The radon gynaecological irrigations and microenemas are performed with the radon concentration of 6.5 kBq/l, temperature 36°C, for 15 minutes within the course of 10-12 procedures. The BAP laser therapy is conducted in an autoresonant mode. The BAPs of anterior median meridian are covered, including: 1-2 (qu-gu), 1-3 (zhong-ji), 1-4 (guan-yuan), 1-5 (shi-men), 1-7 (yin-jiao); renal meridian: R-12 (da-ho), R-13 (qi-xu), R-14 (si-man), R-15 (zhong-zhu), R-16 (huang-shu); bladder meridian: V-31 (shang-liao), V-32 (ci-liao), V-33 (zhong-liao), V-34 (xia-liao); posterior median meridian: T-2 (yao-shu), T-3 (yao-yang-guan), T-4 (min-man), T-5 (xuan-shu). Using the radon baths of the different radon concentrations 'softens' an effect of the absorbed radiation dose on the homeostasis systems and preserves an effect of a high absorbed dose on the genital system. The laser therapy in the autoresonant mode within pathological BAPs improves the accuracy of the exposure on the pathological processes within a target organs.
EFFECT: method prolongs the remission, normalises the hormonal ratios in the remote period.
2 dwg, 4 ex
SUBSTANCE: invention relates to medicine, particularly to ophthalmology. That is ensured by the integrated treatment involving the single macular exposure to a sublimit micro-pulse infrared laser light. That is combined with the ozone therapy using drug preparations with underlying mixed gas agitation. That is followed by an antioxidant therapy consisting of local instillations of emixipin and oral administration of complivit oftalmo.
EFFECT: method enables the therapy of predisciform age-related macular degeneration at the stage of confluent drusens, preventing the development of the disease and improving the visual acuity.
SUBSTANCE: invention refers to medicine and aims at treating the patients with depression of consciousness accompanying acute ischemic strokes using a photochomotherapy with a monochrome green light. With underlying intensive therapy, the patients with depression of consciousness undergo the photochomotherapy involving the contact transorbital exposure on closed eyes alternately. The exposure represents the monochrome green light at average wave length 540 nm, maximum intensity 28.8 mWt, maximum power density 2.8 mWt/cm2, radiant intensity 100%. The exposure length is 5 min for each eye. The exposure length increases by 1 min every next procedure. Once the exposure length reaches 10 min, the exposure length no longer increases. The treatment is started not later than 7 days after the moment of depression of consciousness after diagnosing. The therapeutic course consists of 8-10 daily procedures.
EFFECT: method enables extending the range of aids used in treating the patients with acute ischemic stroke accompanied by depression of consciousness which reduces the length of patient's coma and promotes beginning the rehabilitation actions at the earlier stage, increases the clinical effectiveness and reduces the risk of recurrent stroke, transient ischemic attacks and formation of Wernicke-Mann position.
SUBSTANCE: invention refers to medicine, particularly ophthalmology, and may be used for treating inflammatory and dystrophic eye diseases. If observing an anterior segment of an eyeball, therapeutic agents are administered subcutaneously into a temporal region 1.8-2.2 cm above the middle of a cheek bone into a lymphatic capillary accumulation. If observing a posterior segment of the eyeball, the therapeutic agents are administered subcutaneously 0.8-1.2 cm below the top of a mastoid bone, as well as into the lymphatic capillary accumulation. Heparin in a single dose of 0.3 to 0.6 ml with the therapeutic substance concentration of 96% to 100% is initially administered into the above regions. The basic substance solution in a single dose of 0.6 to 0.8 ml with the therapeutic substance concentration of 45% to 55% is administered thereafter. That is followed by administering Contrykal in a single dose of 0.4 to 0.6 ml with the substance concentration of 45% to 55%. The manipulations are daily for 7-10 days with the therapeutic course repeated every 1-6 months.
EFFECT: method provides better trophism and microcirculation of an optic disk and retina, lower intensity of pathological reactions with obtaining the therapeutic substance concentrations faster, reducing injuries of the manipulation and doses of the administered preparations.