Method for integrated treatment of conditions accompanying hormone-dependent diseases in reproductive females occupied in harmful and specific hazardous working environment

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely gynaecology, physiotherapy. A method involves the integrated treatment of the patients with genital endometriosis and hysteromyoma. The treatment involves taking mineral water, observing a biologically programmed light pattern, taking radon baths and radon gynaecological irrigations and small enemas, as well as conducting a laser therapy of biologically active points (BAPs). The patients take carbonated chloride-hydrocarbonate-sulphate sodium-calcium warm Narzan water taken from sources No. 4, No. 7 and No. 24, 3.4 mg per kg 3 times ad day, 40 minutes before meals. The radon baths are taken with the radon concentration of 1.5 kBq/l. The radon gynaecological irrigations and microenemas are performed with the radon concentration of 6.5 kBq/l, temperature 36°C, for 15 minutes within the course of 10-12 procedures. The BAP laser therapy is conducted in an autoresonant mode. The BAPs of anterior median meridian are covered, including: 1-2 (qu-gu), 1-3 (zhong-ji), 1-4 (guan-yuan), 1-5 (shi-men), 1-7 (yin-jiao); renal meridian: R-12 (da-ho), R-13 (qi-xu), R-14 (si-man), R-15 (zhong-zhu), R-16 (huang-shu); bladder meridian: V-31 (shang-liao), V-32 (ci-liao), V-33 (zhong-liao), V-34 (xia-liao); posterior median meridian: T-2 (yao-shu), T-3 (yao-yang-guan), T-4 (min-man), T-5 (xuan-shu). Using the radon baths of the different radon concentrations 'softens' an effect of the absorbed radiation dose on the homeostasis systems and preserves an effect of a high absorbed dose on the genital system. The laser therapy in the autoresonant mode within pathological BAPs improves the accuracy of the exposure on the pathological processes within a target organs.

EFFECT: method prolongs the remission, normalises the hormonal ratios in the remote period.

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The invention relates to medicine, namely to the gynecologist, and for the treatment of women suffering from hormone-dependent gynecological diseases (genital endometriosis and fibroids).

Known methods of treatment of women suffering from hormone related diseases (genital endometriosis, uterine fibroids) using radon water in the form of baths, gynecological irrigation, microenemas and laser therapy in autoresonance mode on the area of projection of the uterus in conjunction with internal mineral water and compliance with biologically programmed length mode (Ovsienko A.B., Vasiliev S. B., Andreev EJ, Zakharova EL, Urvacheva E.E. Method of treatment of hormone dependent diseases. - RF patent for the invention №2297823 of 27 April 2007).

This method of treatment has a positive effect on the hormonal status (reduction of initial elevated levels of estrogen and increase reduced the concentration of progesterone). Structure of body tissues and cervical cancer, breast cancer is improving: reduced size of foci of tumor processes. When used in complex treatment of internal mineral water normalizes the lipid parameters (cholesterol, LDL, high and low density, the atherogenicity). When a complex application is shown therapeutic factors noted long-term remission - not less 11-12 months.

At the same time, there are cases extensive endometrioid processes that require the use of radon water of high concentration. However, these treatment methods can be used when high concentrations of radon water only in the absence of these women related diseases of the cardiovascular system, pulmonary system, etc. in Addition, the presence of extensive adhesions processes requires looking deeper impact on the lesions.

In the known method of treatment of patients with GSS above, the gynecological area used laser therapy in autoresonance mode. The main difference between laser irradiation (LI) from the radiation of conventional light sources is extremely high spectral brightness. The most important properties there are temporal and spatial coherence, which determines a high degree of monochromaticity, small divergence of the laser beam and the ability to focus it in the minimum spot size, approaching the wavelength (Fingers Y.P., Zheltov GI, Komarov A.A., 1992). The main mechanism of degradation under the action of radiation pulses with a duration of radiation is less than 10 dielectric breakdown of membranes in the field of an intense light wave; when nanosecond pulses prevail thermocast the ical processes, at duration from 1 MS to 5 s - thermal, and with more prolonged exposure to photochemical (Rubin L.V., 1978; Slaine DH, 1981). The most sensitive to the effects of LI and easily destroyed was intracellular membrane system (Carolin A.L., 1982; Bogolyubov V.M., 1987; Komarov A.A., 1989; injushin V.M., 1990; Stepanov V.A., Kaplan M.A., Voronin O.Y, 1990). Various biochemical components of the body - enzymes, hormones, pigments have very individual characteristics of radiation absorption, and therefore DO depending on wavelength has a selective effect on these or other tissues, organs or systems (Fingers Y.P., Zheltov GI, Komarov A.A., 1992).

BM Khromov (1970) describes a series of experiments on irradiation IF the number of malignant tumors in animals, resulting in tumors was significantly decreased in size. The author emphasizes that, due to their biological features of the tumor cells more sensitive to laser radiation than normal cells of the tissue. Found that the decay of the tumor usually begins 3 days after the start of irradiation and ends between 1 and 45 days later. The author notes an increased sensitivity to the laser pigmented tumors. Supplynet (1987) believes that with the aid of laser radiation is almost possible to destroy the tumor with sufficient steintrollet. The author indicates that low-energy WHETHER activates fibroblast processes and physico-chemical changes in the tissue environment. Upon irradiation of experimental tumors in certain types of low-energy WHETHER revealed increased fat cell response. It is known that mast cells are competitive - that is, capture of the intercellular environment polysaccharides, heparin required for other cellular elements, including tumor cells. The author does not exclude that the suspension of tumor growth based on these processes.

N.N. Korolev, N.T. Zagorje (1996) compared the regenerative ability of infrared laser radiation with a frequency of 3000 Hz and 500 Hz in the experiment. Used wavelength of 0.89 μm, average power output 2 W, exposure time 3 minutes. When using a frequency of 3000 Hz, the authors noted a decrease in proliferative activity twice, slowing down epithelialization of wounds. SO Shchepin, A.B. Iglewski (1994) found that improvement in hemodynamics is more pronounced when using a frequency modes from 80 to 1500 Hz.

At the same time, it is now known that the locations of biologically active points (BAP) has more receptors than in other parts of the skin and mucous membranes of the skin, in the field of acupuncture points connective tissue frail, meets many spiral vascular nets twisted bezmalinovic fibers. BAHT actively absorb oxygen, have higher infrared radiation and low electrical resistance, skin temperature is higher than in the surrounding tissues; in the field of acupuncture points is the accumulation of fat cells, which in fact are the regulators of homeostasis.

A.A. Minenkov, T.V. Konchugova, be found kulczycka (1992) found that therapeutic effect of low-energy laser radiation (0.6 and 0.9 µm) effective with the direct irradiation of pathological foci of inflammation and malnutrition than the irradiation reflexogenic zones.

We have developed a scheme of therapeutic effects of laser radiation directly to the area of pathological lesions, but with the impact on the BAHT, which greatly increases the depth of the impact and determines WHETHER the greater efficiency of the applied method of treatment.

The technical result of the invention is to improve the condition of patients with genital endometriosis and fibroids without compromising the flow of comorbidities, smaller foci of endometriosis and myoma nodes, correction of hormonal status with a tendency to normalization of the levels of sex steroids.

The essence of the invention lies in the fact that patients suffering from hormone dependent to ginekologicheski the mi diseases (genital endometriosis, uterine cancer), with concomitant diseases, appoint internal intake of mineral water carbon dioxide chloride-hydrocarbonate-sulphate-sodium-calcium waters warm Narzanov sources N4, N7 and N24, and 3.4 mg per kg of body weight 3 times a day, for 40 minutes before a meal - and compliance with biologically programmed length mode, the complex appoint radon baths with a radon concentration of 1.5 kBq/l, radon gynecological irrigation and microclysters with a radon concentration of 6.5 BCF/l, 36° 15 minutes, in the course of 10-12 treatments and laser therapy in autoresonance mode on biologically active points front middle Meridian - I-2 (qu-GU), I-3 (Zhong-JI), I-4 (Guan yuan), I-5 (Shi-men), I-7 (Yin-Jiao)Meridian kidney - R-12 (da-Hae), R-13 (qi-Xue), R-14 (s-man), R-15 (Zhong-Zhu), R-16 (Huan-Shu); Meridian urinary bubble - V-31 (Shang-Liao), V-32 (s-Liao), V-33 (Zhong-Liao), V-34 (SJ-Liao); posterior median Meridian - T-2 (Yao-Shu), T-3 (Yao Yang Guan), T 4 (min-men), Vol-5 (Suan-Shu).

The method is performed as follows. Patients suffering from hormone related diseases (genital endometriosis and uterine fibroids), in conjunction with a number of comorbidities, stage of sanatorium-resort treatment in combination with internal mineral water for 30-60 minutes before a meal (depending on the state of the gastrointestinal tract) 3 times a day for 3.5 mg/kg of body weight and compliance with ecologo of the illumination mode in accordance with the natural biological rhythms of the human additionally assign radon baths with a radon concentration of 1.5 kBq/l, radon gynecological irrigation and microclysters with a radon concentration of 6.5 BCF/l, 36° 15 minutes, in the course of 10-12 treatments; laser therapy in autoresonance mode on biologically active points (BAP) front middle Meridian: I-2 (qu-GU), I-3 (Zhong-JI), I-4 (Guan yuan), I-5 (Shi-men), I-7 (Yin-Jiao); the Meridian of the kidneys: R-12 (da-Hae), R-13 (qi-Xue), R-14 (s-man), R-15 (Zhong-Zhu), R-16 (Huan-Shu); Meridian of the bladder: V-31 (Shang-Liao), V-32 (s-Liao), V-33 (Zhong-Liao), V-34 (SJ-Liao); posterior median Meridian: T-2 (Yao-Shu), T-3 (Yao Yang Guan), T 4 (min-men), Vol-5 (Suan-Shu).

The method is illustrated by the following examples.

Example 1. Patient M. Zorin. Diagnosis: uterine Myoma of the small sizes. Concomitant diagnosis: Recurrent iron deficiency anemia. Complaints of pain in the lower abdomen and lumbar region of whining, pull problems that arise regardless of the menstrual cycle, bleeding after menstruation for six years. Bimanual examination: an increase in the uterus up to 6-7 weeks of pregnancy, heterogeneous consistency, with a rough surface, painful on palpation.

During examination: clinical analysis of blood - with a decrease in haemoglobin levels to 102, General urine analysis showed no pathology, ECG - without features. In the study of blood hormones definition is the very elevated estradiol levels compared with levels in healthy women at 78% and reduced progesterone level. Ultrasonic examination of the genitalia revealed the heterogeneity of the structure of the myometrium, the front wall is visualized anechoic mass with education 27×18 mm

The patient received the radon baths, gynecological irrigation and micro 36°C, 15 minutes, with the concentration of radon water 180 NCI/l), laser therapy in autoresonance mode on the BAHT against the background of domestic mineral water and adherence to daily lighting. Was carried out the correction of low hemoglobin drug sorbifer 1 tab. 2 times a day on the background of the entire course of treatment.

The results of the treatment. After a course of sanatorium-resort treatment, the patient was significantly reduced abdominal pain, bimanual study was a decrease pain, body size of the uterus (5.5 weeks).

In the clinical analysis of blood, there was an increase in hemoglobin level to 112; urinalysis remained within the normal range, the degree of purity of the vaginal smear - 1-2. ECG - without features. Estradiol levels decreased significantly, remaining elevated compared with levels in healthy women is 11%, the concentration of progesterone increased significantly.

An ultrasound of the genital organs was determined by the improved structure of the myometrium, reducing the size of the myoma node (up to 24×15 mm).

After 12 months, the patient was examined by the camping again when you are on a second course of treatment. The woman remained reduce pain in the lower abdomen. Bimanual examination continued decrease pain and decrease the size of the body of the uterus (5.5 weeks).

In the clinical analysis of blood was noted again the reduced hemoglobin up to 98; urinalysis remained within the normal range, the degree of purity of the vaginal smear - 1-2. ECG - without features. Estradiol levels did not exceed the values in healthy women, progesterone concentration remained close to the level in healthy women.

An ultrasound of the genital organs was determined by some deterioration in the structure of the myometrium, the appearance of moderate patchiness; reducing the size of the myoma node (up to 24×15 mm) was preserved.

Summary. Thus, the patient received in the clinic treatment radon baths, gynecological irrigation and micro 36°C, 15 minutes, with the concentration of radon water 180 NCI/l), laser therapy in autoresonance mode on the BAHT against the background of domestic mineral water and adherence to daily lighting, with correction of low hemoglobin drug sorbifer 1 tab. 2 times a day on the background of the entire course of treatment. The patient endured the procedure well, negative side effects were not. The gynecological organs was observed remission for 12 months. Level g is perestroenii after received medical complex steadily decreased, and progesterone not only improved after a course of therapy, but continued to rise in the long term. However, there was a trend towards a significant reduction of hemoglobin level in the long term, which would increase the weight status of women.

Example 2. Patient Chikishev Elena Vladimirovna. The diagnosis of Adenomyosis uterine body of the II degree. Myomatous node of the uterus. Concomitant diagnosis: Recurrent iron deficiency anemia. Complaints of lower abdominal pain whining character, worse before menses, spotting before and after menstruation, during 3 years.

Bimanual examination: the increase of the uterus body of uterus non - uniform consistency, with a rough surface. On the rear surface of the body of the uterus close to the fundus of the uterus is determined by a dense formation 2 cm in diameter.

During examination: clinical analysis of blood - decrease in haemoglobin levels to 105, General urine analysis showed no pathology, ECG - without features. In the study of hormones in the blood was determined by elevated levels of estradiol compared with the index in healthy women at 94% and reduced progesterone level. Ultrasonic examination of the genitalia revealed the heterogeneity of the structure of the myometrium, on the back wall near the bottom of the body of the uterus lazerette anechoic mass with education 21×14 mm

The patient received the radon baths, gin is substance abuse irrigation and micro 36°C, 15 minutes, bath with concentration of radon water 40 NCI/l, local treatments with the concentration of radon water 180 NCI/l), laser therapy in autoresonance mode on the BAHT against the background of domestic mineral water and adherence to daily lighting. Was carried out the correction of low hemoglobin drug sorbifer 1 tab. 2 times a day on the background of the entire course of treatment.

The results of the treatment. After a course of sanatorium-resort treatment, the patient was significantly reduced abdominal pain, bimanual study was a decrease pain, uterine size, reducing compacted education on the back wall.

In the clinical analysis of blood hemoglobin increased to 115, urinalysis remained within the normal range, the degree of vaginal flora 1-2 degree. ECG - without features.

Estradiol levels decreased, but was higher than in healthy women 15.7%; the concentration of progesterone increased significantly.

An ultrasound of the genital organs was determined by the improved structure of the myometrium, reducing the size of the myoma node (up to 22×11 mm).

After 12 months, the patient was re-examined for admission to a second course of treatment. The woman remained reduce pain in the lower abdomen. Bimanual examination continued decrease pain and decrease the size of the offering of the body of the uterus, improve its consistency.

In the clinical analysis of blood showed stabilization of hemoglobin levels (to 121); urinalysis remained within the normal range, the degree of purity of the vaginal smear - 1-2. ECG - without features. Estradiol levels did not exceed the values in healthy women, progesterone concentration remained close to the level in healthy women.

An ultrasound of the genital organs was determined by steady improvement in the structure of the myometrium, the decrease in patchiness; reducing the size of the myoma node (up to 20×11 mm) was preserved.

Summary. Thus, the patient received in the clinic treatment radon baths, gynecological irrigation and micro 36°C, 15 minutes, with the concentration of radon water 40 NCI/l in obtaining baths and 180 NCI/l - local procedures), laser therapy in autoresonance mode on the BAHT against the background of domestic mineral water and adherence to daily lighting, with correction of low hemoglobin drug sorbifer 1 tab. 2 times a day on the background of the entire course of treatment. The patient endured the procedure well, negative side effects were not. The gynecological organs was observed remission for 12 months. The level of hyperestrogenemia after received medical complex steadily decreased and proves the erona not only improved after a course of therapy, but continued to rise in the long term. However, there was a trend towards a significant reduction of hemoglobin level in the long term, which would increase the weight status of women.

Example 3. Sick Cooper M.A. Diagnosed with Genital endometriosis (adenomyosis of the uterus), uterine body cancer of the small sizes. Concomitant diagnosis: Autoimmune thyroiditis. Complaints about violations of ovario-menstrual cycle, pain in the lower abdomen of the pull of nature, intermenstrual bleeding for nine years.

Bimanual examination: an increase in the uterus up to 6-7 weeks of pregnancy, heterogeneous consistency, with a rough surface, painful on palpation.

During examination: clinical blood and urine tests - without a pathology, ECG - without features. In the study of hormones in the blood was determined by elevated levels of estradiol (274,3 PG/ml) compared to healthy women 98% and a decrease in the level of progesterone in the second phase of the cycle (6.2 nmol/l). When ultrasound of the genital organs was determined by multiple echopositive polymorphic inclusions with irregular contours around the myometrium.

The patient received the radon baths, gynecological irrigation and micro 36°C, 15 minutes, with the concentration of radon water 180 NCI/l), laser therapy in autoresonance mode on the BAHT against the background vnutrennih the intake of mineral water and adherence to daily lighting.

The results of the treatment. After a course of sanatorium-resort treatment, the patient was significantly reduced abdominal pain, restored menstrual cycle, bimanual study was a decrease pain, body size of the uterus (5.5 weeks) and foci of endometriosis.

Clinical blood and urine tests remained within normal limits, the degree of purity of the vaginal smear - 1-2. ECG - without features. Estradiol levels decreased (147,6 PG/ml), remaining slightly increased in comparison with the index in healthy women, the concentration of progesterone increased (14.6 nmol/l).

When ultrasound of the genital organs was determined by the improved structure of the myometrium (General decrease in the number of ekopozytywny polymorphic impurities, smooth the contours of inclusions, reducing the size of the source is increased uterine body).

Patient after 1 year (12 months) with repeated treatment in the clinic was re-examined. By the end of the late period, the patient had worsening weakness, drowsiness and lowering efficiency. Before menstruation, the woman began to notice the appearance of bloating, irritability, anxiety and depression. The clinical status of symptoms of genitals, data inspection and palpation, ultrasound examination of the genitalia, hormonal issled the work remained practically unchanged compared with the status after the course of therapy. The patient also noted the reduction of spotting before menstruation up to 2 days.

Summary. Thus, the patient received in the clinic treatment radon concentration radon water 180 NCI/l and laser therapy in autoresonance mode on the BAHT against the background of domestic mineral water and adherence to daily lighting, endured the procedure well, negative side effects were not. Observed remission for 12 months. The level of hyperestrogenemia after received medical complex steadily decreased, in comparison with the original index by 45%. Dimensions affected by endometriosis of the uterus according to bimanual and ultrasonic examinations decreased by 19% from the original size. At the same time exacerbated the weakness appeared anxiety-depression and other symptoms associated with reduced basal metabolic rate, which ultimately determined the necessity of searching correction in General position.

Example 4. Patient N. Gubanov Diagnosed with Genital endometriosis (adenomyosis of the uterus), uterine body cancer. Concomitant diagnosis: Autoimmune thyroiditis. Complaints about violations of ovario-menstrual cycle, pain in the lower abdomen of the pull of nature, intermenstrual bleeding for seven years.

Bimanual examination - an increase in the uterus until 7-8 weeks is beremennosti, heterogeneous consistency, with a rough surface, sharply painful to palpation.

During examination: clinical blood and urine tests - without a pathology, ECG - without features. In the study of hormones in the blood was determined by elevated levels of estradiol (263,3 PG/ml) compared to healthy women at 92% and reduced progesterone level (7.5 nmol/l). When ultrasound of the genital organs was determined by multiple echopositive polymorphic inclusions with irregular contours around the myometrium.

The patient received the radon baths, gynecological irrigation and micro 36°C, 15 minutes, with the concentration of radon water 40 NCI/l when taking baths and 180 NCI/l, with the admission of local procedures), laser therapy in autoresonance mode on the BAHT against the background of domestic mineral water and adherence to daily lighting.

The results of the treatment. After a course of sanatorium-resort treatment, the patient was significantly reduced abdominal pain, restored menstrual cycle, bimanual study was a decrease pain, body size of the uterus (5-6 weeks) and foci of endometriosis.

Clinical blood and urine tests remained within normal limits, the degree of purity of the vaginal smear - 1-2. ECG remained without features. Estradiol levels decreased (157,6 PG/ml), left the camping somewhat increased in comparison with the index in healthy women, the progesterone concentration was increased to 15.2 nmol/l).

When ultrasound of the genital organs was determined by the improved structure of the myometrium (General decrease in the number of ekopozytywny polymorphic impurities, smooth the contours of inclusions, reducing the size of the source is increased uterine body).

Patient after 1 year (12 months) with repeated treatment in the clinic was re-examined. Clinical status, physical examination and palpation, ultrasound examination of the genitalia, hormonal studies remained virtually unchanged compared with the status after the course of therapy. The patient also noted the reduction of spotting before menstruation up to 2 days.

Summary. Thus, the patient received in the clinic treatment radon baths, gynecological irrigation and micro 36°C, 15 minutes, with the concentration of radon water 40 NCI/l when taking baths and 180 NCI/l, with the admission of local procedures), laser therapy in autoresonance mode on the BAHT against the background of domestic mineral water and adherence to daily lighting, endured the procedure well, negative side effects were not. Observed remission for 12 months. The level of hyperestrogenemia after received medical complex steadily decreased, in comparison with the original figure is 46%. Dimensions astonishment the endometriosis of the uterus according to bimanual and ultrasonic examinations decreased by 20% from the original size.

In this way at the gynecology Department of Pyatigorsk clinic treated 134 women with GSS (76 people with genital endometriosis, 58 with uterine fibroids). Women had comorbidities (anemia, autoimmune thyroiditis, diseases of the hepatobiliary system, some variants of cardiovascular disease and others). In the control group was observed in 74 patients with GSS, 38 women (33,9%) with genital endometriosis, 36 (32,2%) with uterine fibroids. Patients in the control group received a Spa treatment: radon treatment in the form of baths, gynecological irrigation and microenemas temperature of 36°C, with exposure time of each procedure 15 minutes, 180 NCI/l, at a rate of 10-12 procedures. Not earlier than 2 hours after receiving radon procedures or in interleaving with radon treatments a day was prescribed laser therapy in autoresonance mode: in genital endometriosis and uterine myoma - gynecological area (the projection of the body of the uterus) without capture of the projection area of the ovaries. Patients of the control group also received carbon dioxide chloride-hydrocarbonate-sulphate-sodium-calcium water warm Narzanov sources N4, N7 and N24, and 3.4 mg per kg of body weight 3 times a day, for 40 minutes before a meal. Women were also observed biologically programmed light mode.

Patients of the main group sets the CNS with internal mineral water for 30-60 minutes before a meal (depending on the state of the gastrointestinal tract) 3 times a day for 3.5 mg/kg of body weight and keeping the light illumination mode in accordance with the natural biological rhythms person appointed radon baths with a radon concentration of 1.5 kBq/l, radon gynecological irrigation and microclysters with a radon concentration of 6.5 BCF/l, 36° 15 minutes, in the course of 10-12 treatments, laser therapy in autoresonance mode on biologically active points (BAP) meridians: front middle Meridian - I-2 (qu-GU), I-3 (Zhong-JI), I-4 (Guan yuan), I-5 (Shi-men), I-7 (Yin-Jiao); kidney - R-12 (da-Hae), R-13 (qi-Xue), R-14 (s-man), R-15 (Zhong-Zhu), R-16 (Huan-Shu); bladder - V-31 (Shang-Liao), V-32 (s-Liao), V-33 (Zhong-Liao), V-34 (SJ-Liao); posterior median Meridian - T-2 (Yao-Shu), T-3 (Yao-Yang-Guan), T 4 (min-men), Vol-5 (Suan-Shu).

Both groups in clinical terms were identical. All patients with genital endometriosis and more than half of the patients with uterine fibroids complained of pain in the lower abdomen, appearing in the premenstrual or menstrual periods, spotting before menstruation, fibroids was observed profuse bleeding during menstruation, prolonged bleeding.

Patients of both groups underwent bimanual examination, the study of hormones in the blood during the second phase of the menstrual cycle (FSH, LH, prolactin, estradiol and progesterone), an ultrasound scan of the genitals, a Doppler ultrasound of the pelvic organs.

In the study of blood hormones in women in both groups identified ALIS increased values of estradiol and reduced progesterone level. It should be noted that patients with genital endometriosis estradiol concentration exceeded the average values in healthy women (167±52,4 PG/ml) average of 69.5%, uterine fibroid by 27%. Progesterone was reduced more evenly in both nosologies: below level in healthy women at GE by 85.6% and 45.3% in MM.

Ultrasonic examination of the genitalia in genital endometriosis was determined by multiple echopositive polymorphic inclusion of heterogeneous with irregular contours, in the myometrium different parts of the body of the uterus. When uterine fibroids are determined in General thickening of the walls of the uterus, nodular inclusions, giving the acoustic shadow deforming the outer and inner contours of the body of the uterus. In both pathological processes was determined by the increasing size of the uterus.

When abnormal Doppler waveforms were determined poor circulation according to the indexes of resistance, systole-diastolic ratios ovarian and uterine arteries.

After complex of sanatorium-resort treatment in both groups observed patients had a significant improvement from the sexual sphere: reduction of pain in the abdomen, reducing the size of lesions bimanual, palpation and ultrasound studies have all observed patients, more markedly is in the main group of observation.

In the study of blood hormones in women in both the main and control groups after treatment noted marked reduction in the levels of estradiol and increase progesterone levels after treatment in patients with genital endometriosis estradiol concentration exceeded the average values in healthy women, on average, 23.6%, uterine fibroid - by 17.3% in the control group, in the GE - 27.7%, uterine fibroid - by 18.1%. Progesterone levels are increased in patients of the main group at GE 43%, uterine fibroid 87% in relation to the indicators in healthy women (control group at GE - by 54.4%, MM - by 95.7%).

Ultrasonic examination of the genitalia in genital endometriosis was determined smoothness structure of the myometrium in women of the main group and more correct, "soft" paths foci ekopozytywny polymorphic inclusions in patients of the control group. When uterine fibroids were determined smoothness structure of the myometrium in the areas of myometrium between nodular, more notable women of the main group and a decrease in the size of nodes bessamatic differences in both groups of observations. In both pathological processes was determined by reducing the size of the uterus, the more significant in patients with genital endometriosis. Noticeable differences in the step is no decrease in size of the uterus in patients of both groups were not found. When ultrasound volume of the body of the uterus after treatment for Lyubimova (1975) has decreased from a core group of women with genital endometriosis 23.3%, with uterine fibroids - 13.4%; in the control group the decrease in the volume of the body of the uterus, respectively 24,7% and 15.9%.

When abnormal Doppler waveforms according to the indexes of resistance and systolicdiastolic proportions of the ovarian and uterine arteries was determined to improve blood circulation.

At the same time, women in the control group continued with anemia trends to low level of hemoglobin, cardiovascular diseases and autoimmune thyroiditis is not decreased symptoms of poor tolerability General baths, weakness, fluctuations in blood pressure, symptoms of shortness of breath, etc. of Such phenomena in the group of patients with differentiated by assigning more procedures was not.

Remission in the main group was 18-21 months, in the control group 12-14 months.

When examining hormonal levels in the long term estradiol levels exceed the values in relation to the indicators in healthy women 33.2% for GE and uterine fibroid - 25.6% in the control group, in the GE - 48.9%, uterine fibroid - 39.4%. The progesterone level in the long term in patients of the main group at GE decreased relative to the rate after treatment was lower than in healthy women, 23.5%, with uterine match is - in relation to the indicators in healthy women was increased by 12.7% in the control group at GE was lower than in healthy women, 14.8%, with MM - in relation to the indicators in healthy women was increased by 94.6%).

On comorbidity in women of the main group condition was stable and in comparison with the state of women in the control group is much better on clinical evaluation, routine clinical laboratory tests (CBC and urinalysis) and ECG.

Thus, the application at the stage of sanatorium-resort treatment of differentiated radon therapy and laser therapy in autoresonance mode on the BAHT, which is located directly in the area of pathological lesions, promotes a pronounced lengthening of remission in patients with genital endometriosis and uterine fibroids, improved clinical status, stabilization and more pronounced normalize hormonal relationships in the long term, to improve the rest of the data of objective examination. The use of radon treatments with different concentrations of radon "soften" the impact of the absorbed dose of radiation to a system homeostasis and preserves the effect of high absorbed dose of radiation on the sex organs target organs for the influence of sex hormones. The use of laser therapy in autoresonance mode on the BAHT, R is polozhennym directly in the field of pathological lesions, improves the accuracy of the impact on pathological processes in the target organs and enhances the positive aspects of the systemic influence of the applied treatment on hormonal control through biologically active points.

A brief description of the drawings.

Charts showing changes in the levels of estradiol in patients with hormone-dependent gynecological diseases (genital endometriosis, uterine fibroids) before treatment, after the course of therapy and in the long term. All values are given in percentage deviation from the level of estradiol in healthy women. Original in both groups was determined by the increased values of estradiol, and in patients with genital endometriosis estradiol concentration exceeded the average values in healthy women to a greater extent than when the fibroids, which can be seen from (reg. After treatment noted marked reduction in the level of estradiol in both groups, observations, and long-term stabilization of these parameters.

Values of progesterone in the remote period in the control group in patients with uterine cancer continued to rise and remained high at GE; in the study group had a large normalization of indicators that can be seen from Figure 2

A method of treating patients suffering from hormonesensitive gynecological diseases (intalnim endometriosis, uterine cancer), with concomitant diseases, including internal intake of mineral water carbon dioxide chloride-hydrocarbonate-sulphate-sodium-calcium waters warm Narzanov sources N4, N7 and N24, and 3.4 mg per kg of body weight 3 times a day, for 40 minutes before a meal - and compliance with biologically programmed length mode, wherein in the complex appoint radon baths with a radon concentration of 1.5 kBq/l, radon gynecological irrigation and microclysters with a radon concentration of 6.5 BCF/l, 36° 15 minutes, in the course of 10-12 treatments and laser therapy in autoresonance mode on biologically active points of the front middle Meridian - I-2 (qu-GU), I-3 (Zhong-JI), I-4 (Guan yuan), I-5 (Shi-men), I-7 (Yin-Jiao)Meridian kidney - R-12 (da-Hae), R-13 (qi-Xue), R-14 (s-man), R-15 (Zhong-Zhu), R-16 (Huan-Shu); bladder-Meridian - V-31 (Shang-Liao), V-32 (s-Liao), V-33 (Zhong-Liao), V-34 (SJ-Liao); posterior median Meridian - T-2 (Yao-Shu), T-3 (Yao Yang Guan), T 4 (min-men), Vol-5 (Suan-Shu).



 

Same patents:

FIELD: medicine.

SUBSTANCE: azithromycin infusions are combined with the daily administration of metronidazole. Azithromycin is administered in a single dose of 1.0 g on the 5th post-infusion day. The treatment is combined with the daily administration from the first day of the metronidazole therapy twice a day in a dose of 500 mg for 14 days.

EFFECT: effective treatment ensured by reducing a dose and risk of side effects.

3 ex

FIELD: medicine.

SUBSTANCE: invention refers to veterinary gynaecology, particularly to treating acute postpartum endometritis in cows, and can find application in dairy farms and complexes. A method of treating acute postpartum endometritis in cows involves the intrauterine administration of an antimicrobial agent with the antimicrobial agent being presented by an emulsion consisting of sterile sunflower oil, the preparation ASD-3 and oxytetracycline, prepared of sterile sunflower oil 1000 ml added with the preparation ASD-3 35 ml and oxytetracycline-200 30 ml; the prepared suspension is kept at a room temperature for one day; before the administration, the emulsion is heated to temperature 38-39°C and administered in a dose of 110-150 ml per one animal 2-3 times every 48 hours.

EFFECT: method enables the higher therapeutic effectiveness in acute postpartum endometritis in cows by 25-30%, makes the treatment 8 days shorter.

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely gynaecology, and is applicable for treating chronic endometritis. For this purpose, the standard medical therapy is added by administering Cytoflavin in therapeutic doses: 10.0 in 200.0 of 0.9% normal saline intravenously drop-by-drop once a day for 10 days. Then, the therapeutic preparation is introduced orally in a dose of 2 tablets 2 times a day for 20 days.

EFFECT: method provides the higher clinical effectiveness.

1 ex

FIELD: medicine.

SUBSTANCE: invention relates to veterinary science. A method for preparing a bacterial preparation for preventing bovine postpartum endometritis consisting in the fact that preparing involves making a dry nutrient broth for microorganism culture (DNB) according to the package insert; the prepared broth is added with 3% starch pre-dissolved in a small amount of the cooled broth, and then mixed with the rest DNB; the broth is brought to the boiling point, boiled to produce a homogenous transparent mass; then the medium is added with 0.125% NaCl and 2% glucose to pH 6-7, then a phosphate buffer is added: one-substituted 0.8% potassium KH2PO4 and 0.18% two-substituted potassium or sodium K2HPO4 or Na2HPO4; the solution is boiled for 15 minutes, and after cooling, it is added with 0.5% of 80% lactic acid, filtered and autoclaved at 0.5 atm. for 30-40 min; after the solution has been cooled, it is added with the prepared cultures of Lactobacillus fermentum 44/1 and Lactococcus lactis subsp.Lactis 574 no 1 bln. of the microbial cells per 100 ml of the medium in the sterile environment; it is packaged and thermostated for 48 hours at t=37°C. The preparation is tested in 56 cows for the purpose of preventing bovine postpartum endometritis.

EFFECT: invention provides reducing the cost price of the preparation as compared to its prototype by 60%, without impairing the prophylactic efficacy, eliminates using antibiotics and derivatives thereof, sulphanyl amides, nitrofuranes and thereby eliminates side action of the preparation on animal's body.

1 tbl, 2 ex

Oxytocin analogues // 2496788

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to new oxytocin analogues, pharmaceutical compositions containing them, using these compounds in preparing a drug for treating lactation disorders particularly. The compounds are presented by general formula as additionally specified in the description.

EFFECT: preparing the new oxytocin analogues.

16 cl, 2 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely gynaecology, and may be used for treating the patients with chronic non-specific endometritis. The method is implemented as follows: a therapeutic agent that is polyvalent complex pyobacteriophage in a dose of 4-7 ml is introduced in a female patient with a completely empty bladder on the 5-7th postmenstrual day. There are 5 procedures of administering pyobacteriophage required. That is followed by the exposure to low-intensity infrared pulse laser at wave length 0.89 mcm, frequency 80 Hz, pulse power 5 Wt; the cutaneous daily 10-minute exposure covers the underbelly. For the 5 of 10 minutes, the exposure covers a projection of the uterus, while for the rest 5 minutes, a projection of the annexes are exposed. The therapeutic course is 10 procedures. Besides, the underbelly exposure is combined with the daily exposure covering a projection of the cubital vessels and the suprasternal notch for 2-3 minutes with the therapeutic course making 10 procedures. The exposure on a projection of the cubital vessels and the suprasternal notch may be both combined with the underbelly exposure, and follow the same.

EFFECT: method provides the clinical effectiveness and provides ensures reducing the clinical manifestations of the disease, improving the ultrasound, doppler and laboratory parameters, normalising the genital micro-biocoenosis, optimising the female reproductive functions in a combination with a low rate of potential systemic side effects.

3 cl, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to cosmetic industry, in particular to preparation for women's intimate hygiene. Application of coniferous natural water extract as active component of preparation for women's intimate hygiene. Preparation for women's intimate hygiene, which contains coniferous natural water extract and soapy base, taken in specified ratio. Preparation for women's intimate hygiene for prevention and treatment of gynecological diseases, which contains coniferous natural water extract and soapy base, taken in specified ratio.

EFFECT: preparations are effective for women's intimate hygiene, have increased antibacterial activity, do not cause irritation on mucosa and skin, as well as have increased duration of influence of active components.

9 cl, 2 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to a pharmaceutical tablet for oral administration containing ulipristal acetate 3-18 wt %; a diluent 60 - 95 wt % specified in lactose monohydrate, microcrystalline cellulose, cellulose, mannitol and combinations thereof; a binding agent 0 - 10 wt % specified in hydroxypropyl methyl cellulose, povidone and combinations thereof; sodium croscarmellose 1 - 10 wt % and magnesium stearate 0.5 - 4 wt %.The invention also refers to a method for preparing the above tablet which involves mixing the ingredients and forming the tablet by wet granulation or direct compression.

EFFECT: invention provides the new formulation of the tablet with improved disintegration.

13 cl, 2 dwg, 5 tbl, 6 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: there are presented: using 3-alpha-androstanediol and 5-HT1A agonist for preparing a drug for sexual dysfunction on demand, wherein above 3-alpha-androstanediol and 5-HT1A agonist substantially release at the same time approximately from one to two hours before sexual activity, thereby peak effects of 3-alpha-androstanediol and 5-HT1A agonist (particularly, of flesinoxan) coincide in time at least partially; the respective pharmaceutical composition and kit for treating sexual dysfunction on demand. The declared drug, composition and kit may additionally contain type 5 phosphodiesterase inhibitor (PDE5 - sildenafil).

EFFECT: invention provides a short (over a few hours) superphysiological peak of blood 3-alpha-androstanediol that provides calling the greatest possible attention to erotic symbols and sexual motivation, and relieving the depressed behavioral responses to the maximum.

11 cl

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to veterinary science, particularly to methods and drugs for prevention and treatment of obstetric and gynecological diseases in cows. The agent for prevention of endometritis in cows contains an antimicrobial agent and a base with the antimicrobial agent presented by the above-critical CO2-marigold extract, while the base is silicone glycerolate - organic-silicon glycerohydrogel that is a water-soluble organic-silicon glycerol derivative possessing transmucous activity with its composition described by formula (CH3)2Si(C3H7O3)2xC3H8O3, in the following relation, wt %: above-critical CO2 marigold extract - 0.5; organic-silicon glycerohydrogel - up to 100. The drug uses above-critical CO2-marigold extract produced by Grumant LLC, the Novgorod Region. A method for prevention of endometritis in cows involves the integrated therapy with intra-uterine administration of the above drug cows for 3-5 times every 48 hours, at 100-200 g per one administration, wherein the drug is diluted in sterile water in ratio 1:2 before use.

EFFECT: drug possess a high penetrating effect, the group of inventions provides the more effective prevention of endometritis in cows.

3 cl, 6 tbl

FIELD: medicine.

SUBSTANCE: invention relates to medicine, particularly to ophthalmology. That is ensured by the integrated treatment involving the single macular exposure to a sublimit micro-pulse infrared laser light. That is combined with the ozone therapy using drug preparations with underlying mixed gas agitation. That is followed by an antioxidant therapy consisting of local instillations of emixipin and oral administration of complivit oftalmo.

EFFECT: method enables the therapy of predisciform age-related macular degeneration at the stage of confluent drusens, preventing the development of the disease and improving the visual acuity.

2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to surgery, and may be used in treating trophic ulcers and infected persistent wounds. That is ensured by the exposure to an argon plasma flow in a dose of 100-250 J/cm2 at 10-25 cm from the treated surface. The exposure length on one field makes 10-25 seconds. The sound surface treatment is followed by the dynamic exposure to a running argon plasma flow at 10-20 cm in a dose of 80-150 J/cm2 over the whole wound surface to form a gloss on the wound surface.

EFFECT: method provides the effective treatment of the given pathology ensured by specifying a mode of the exposure causing the microorganism elimination, wound surface drying, sudden perifocal oedema reduction, as well as epithelial cell growth stimulation on the periphery of the wound, as well as on its free surface.

3 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine. A method of treating the patients with the complicated forms of diabetic foot by blood sampling, centrifugation, plasma removal, erythrocyte fraction recovery, introduction of the angiotropic drug alprostadil, exposure to laser light at power 12 mWt for 20 minutes, addition of normal saline 100 ml in erythrocyte fraction 200 ml and reinfusion for 1.5-2 hours; ATP 2 ml is combined with the angiotropic drug alprostadil and introduced into the erythrocyte fraction; the erythrocyte fraction is reinfused every second day, alternated with intravenous drop-by-drop introduction of Vessel-DUE-F 600 LSU and actovegin 5 ml per normal saline 100 ml; the therapeutic course is 10 days.

EFFECT: using the method provides higher effectiveness and reduces the length of treatment of the patients with the complicated forms of diabetic foot syndrome, promotes the longer preservation of the achieved therapeutic effect.

FIELD: medicine.

SUBSTANCE: invention refers to medicine. Treating nosocomial sinusitis in resuscitation and intensive care units is ensured by nasal cavity clearance and sinus irrigation according to the common technique using a Kulikovsky's needle. The solution of polymyxin E in the concentration of 133 mcg/ml is introduced for 10 minutes before sinus administration of a photosensitiser that is methylene blue 20 ml in the concentration of 15 mcg/ml. The contents are aspirated with a syringe. The sinus mucosa is exposed to laser light through a dissipative light guide introduced through the Kulikovsky's needle at wave legnth 660 nm, power 500 mWt, emission length 23.5 minutes.

EFFECT: method enables enhancing the photodynamic effect on the gram-negative microorganisms ensured by including polymyxin E relieving the photosensitiser adhesion on the surface of a gram-negative bacterial cell into the method of the photodynamic therapy.

2 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely - to physiotherapy, urology. A method involves the integrated physiotherapeutic effect of three physical factors. The ultrasonic exposure is characterised by frequency 2.7 kHz + 0.2 kHz, length 9 ms, pulse period 200 ms. The exposure to magnetic field is characterised by magnetic induction amplitude 1300 mT, pulse period 80 ms. The laser exposure is characterised by power 5.0 Wt, frequency 80 Hz. Total duration of a procedure is 30 minutes.

EFFECT: due to using the sequential effect of three physical factors, the method reduces the period of small urolith evacuation, the intensity of pain syndrome, requirement in analgesic and anti-spasmodic drugs, minimises the development of sclerotic changes in the ureter wall that improves urinary outflow and reduces a risk of recurrent urolith formation.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely - to neurology. The method involves the integrated treatment. Azathioprine, dexamethasone and analgin are administered into the patient. Azathioprine 50 mg is administered three times a day, after meals for 21 days. Dexamethasone 4 mg is administered intramuscularly three times a day for 15 days. From the 16th to 18th day of treatment, dexamethasone 4 mg is administered 2 times a day - in the morning and afternoon. From the 19th to 20th day, the same is administered in a dose of 4 mg in the afternoon. Before bedtime, 50% analgin 2.0 ml is administered parenterally for 10 days. At 9 o'clock in the morning, patient's lumbar pain area is exposed to the magnetic laser treatment. The patient is exposed to infrared light of wave length 0.8-0.9 mcm, pulse power 5-8 Wt, pulse frequency 1000 Hz and magnetic strength 35 mT. The exposure is contact and stable, and covers the fields paravertebrally. The length of the one-field exposure is 2 minutes. The therapeutic course is 15 procedures. Trives spinal assistant is put on in the horizontal position of lying on back. The spinal assistant is taken off in the horizontal position before bedtime.

EFFECT: method reduces the length of treatment, prolongs a remission, including due to the developed modes and combinations of the various components of the exposure.

1 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to - physiotherapy, to infectious diseases. The method involves the integrated use of drug preparations, magnetic and laser therapy. The laser therapy is differentiated depending on the severity, modified leukocytal intoxication index (mLII), malondialdehyde (MDA), lipid hydroperoxide (LHP), antioxidant activity (AOA), interleukin-1β (IL-1β), tumour necrosis factor (TNF-α). The mild severity, mLII within the range of 2.8±0.09-3.44±0.07, MDA 3.7±0.08-4.2±0.07mcm/ml, LHP 10.1±0.1-11.3±0.09 mcm/ml, AOA 0.489±0.005-0.390±0.007, IL-1β 25.3±0.5-26.71±0.3 pg/ml; TNF-α 37.1±0.5-45.7±0.8 pg/ml require the daily percutaneous exposure to a constant magnetic field and low-intensity laser light of power 55 mWt, wave length 0.89 mcm, pulse frequency 80 Hz in the morning hours. The contact scanning exposure covers a projection of thymus, regional lymphatic nodes and great vascular pedicle. The length of the exposure makes 60 seconds per each region. Then, an inflammatory centre is exposed to pulse red light of wave length 0.65 mcm, output pulse power min. 5 Wt, pulse frequency 80 Hz, modulation frequency of light-emitting diodes 8 Hz generated by a light guide tip. The length of the exposure is 120 minutes. The therapeutic course consists of 5 procedures. The moderate severity, mLII 4.18±0.08-6.06±0.07, MDA 4.9±0.03-5.6±0.02 mcm/ml, LHP 12.3±0.08-14.7±0.07 mcm/ml; AOA 0.345±0.007-0.315±0.006, IL-1β 27.1±0.2-28.1±0.1 pg/ml, TNF-α 57.7±0.9-72.1±0.5 pg/ml requires the daily percutaneous exposure to the constant magnetic field and low-intensity laser light of power 60 mWt, wave length 0.89 mcm, pulse frequency 80 Hz in the morning hours. The contact scanning exposure covers a projection of thymus, regional lymphatic nodes and great vascular pedicle. The length of the exposure makes 90 seconds per each region. Then, an inflammatory centre is exposed to pulse red light of wave length 0.65 mcm, output pulse power 7 Wt, pulse frequency 80 Hz, modulation frequency of light-emitting diodes 8 Hz generated by the light guide tip. The length of the exposure is 150 minutes. The therapeutic course is 7 procedures. The severe condition, mLII 7.76±0.08-8.06±0.07, MDA 7.1±0.03-11.6±0.02 mcm/ml, LHP 16.3±0.08-19.7±0.07 mcm/ml; AOA 0.310±0.007-0.294±0.006, IL-1β 30.1±0.2-31.1±0.1 pg/ml, TNF-α 76.7±0.9-85.1±0.5 pg/ml requires the daily percutaneous exposure to the constant magnetic field and low-intensity laser light of power 60 mWt, wave length 0.89 mcm, pulse frequency 80 Hz in the morning hours The contact scanning exposure covers a projection of thymus, regional lymphatic nodes and great vascular pedicle. The length of the exposure makes 120 seconds per each region. Then, an inflammatory centre is exposed to pulse red light of wave length 0.65 mcm, output pulse power 9 Wt, pulse frequency 80 Hz, modulation frequency of light-emitting diodes 8 Hz generated by the light guide tip. The length of the exposure makes 180 seconds. The therapeutic course consists of 9 procedures. For the first five days, all the patients are prescribed with heparin electrophoresis by common technique during afternoon.

EFFECT: method reduces a rate of recurrence.

3 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely - to physiotherapy, paediatrics and neurology. The patient is exposed to a EEG-assisted combination of a magnetic field and laser light. The exposure involves a running magnetic field in a continuous mode. The inductance is 6-40 mT, and frequency is 50 Hz. The exposure involves laser light at wave length 0.85-0.9 mcm, frequency 50 Hz, power 3.5-5 mWt. The exposure is bitemporal along the spinal column at the level of C1-L1. Duration of a procedure is 10-12 minutes. The procedures are daily. The therapeutic course is 10 procedures.

EFFECT: higher clinical effectiveness ensured by activation of the cognitive functions.

3 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to oncology and radiotherapy, and deals with prediction of efficiency of radiotherapy of malignant neoplasms of oropharyngeal zone. Before treatment index of blood microcirculation Im and average degree of oxygenation of mixed blood of microcirculature StO2 in tumour are registered. Said indices are used to determine perfusion oxygen saturation, and values of blood microcirculation index Im' and average degree of oxygenation of mixed blood of microcirculature StO2' in intact zone are measured. Average volume blood filling Vb in tumour and in intact region Vb' are registered, level of activity of oxygen metabolism in cells in examined areas MA, MA' is determined by given formulas. If MA/MA'≥2.5, efficiency of radiotherapy is predicted, if MA/MA'<2.5, conclusion about high probability of residual volume of tumour after carrying out radiotherapy is made.

EFFECT: method makes it possible to predict efficiency of tumour regression to impact of distant radiotherapy still at pre-hospital stage, which in its turn contributes to correct and timely selection of method of treatment in accordance with individual plan.

3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to anaesthesiology, resuscitation and urology, and can be applied for prevention of cardiovascular complications in patients with syndrome of endogenous intoxication against the background of acute purulent pyelonephritis in perioperative period. For this purpose reamberine 1.5% in dose 400 ml is introduced to patient from the moment of clinical diagnosis daily to the moment of performing operation. After that, in the process of operation, at the stage of kidney decapsulation infusion of reamberine in the same dose in combination with intravenous blood irradiation is realised, with duration constituting 25 minutes. After that, in post operational period reamberine infusion is continued in the same dose during 8 days. Simultaneously for 3 days after operation intravenous blood irradiation is realised. From the 4-th day of post-operative period for five days reamberine infusions 1 time per day are combined with transdermal laser irradiation of operated kidney projection with duration 10 minutes. Then, without stopping reamberine infusion, biologically active points, connected with heart meridian C1, C2, C3, C4, C5, C6, C7, C8, C9, sympathetic point of heart meridian V15, ear points AP19, AP21, AP60, AP100, AP105, AP115 are successively exposed to laser irradiation.

EFFECT: method ensures effective prevention of cardiovascular complications due to reduction of level of toxic action of products of peroxide oxidation of lipids on myocardium, which makes it possible to improve functional state of myocardium.

1 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to physiotherapy, balneotherapy. Taking baths is realised. Bath includes gas-saturated water, and beer. Saturation with gas is performed by addition of fresh non-filtered beer in ratio 1:10 and supply of air, heated to 25°C from bottom to top. 1/2 part of water, heated to 40°C is poured into bathtub. After that, beer is added and then water, heated to 40°C, in amount of remaining 1/2 part. Bathtub is made from oak with holes.

EFFECT: method increases efficiency of bath realisation due to complex impact on organism with thermal and chemical factors and aeromassage.

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