Method of determining dispersion of amplitude-frequency characteristics of brain alpha-rhythm in case of mental illnesses

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to neurophysiological methods of examination. Registration of EEG is carried out, total power of modal fluctuation in alpha-rhythm range in one of leads is determined and FRα1 index is calculated as ration of said power to total power of all alpha range fluctuations in the same lead. Value of the sum of power of fluctuations, located ±0.5 Hz on the right and on the left from maximal power value, including maximal value, is determined, and FRα2 index is calculated as ratio of the obtained sum of power to total power of all fluctuations of alpha-range in the same lead. Intensity of brain affection is determined by comparison of obtained FRα1 and FRα2 values with standard values.

EFFECT: method makes it possible to determined quantitative ratio of alpha-rhythm, characteristic of separate nosologic units in psychiatry.

2 tbl, 1 dwg


The invention relates to medical applications, in particular neurophysiological research methods.

There is a method of determining the spectral radiation power of the alpha rhythm as its amplitude-frequency characteristics when conducting EEG studies of the brain. The mathematical basis of the amplitude-frequency analysis is the Fourier transform which takes various forms depending on the type of the analyzed signals. Common is the assumption that the studied processes (signals) are composed of a certain number (possibly infinite) of sine and/or cosine components (harmonics) successively increasing the number of frequencies. The Fourier transform decomposes the signal into a series of harmonic components without any loss of information (if arithmetically combine all harmonics, we get again the original signal). Each harmonic is determined by three parameters: amplitude, initial phase and frequency. The dependence of the amplitude and phase of the harmonics of the frequency is called the spectrum. The power spectrum P(i)=f(fi) represents the amplitude spectrum, squared P(i)=A(i)2. In practice, the spectral analysis of the EEG by using the built-in computer encephalograph programs. ISCO the initial power spectrum of a particular frequency of radiation can be displayed in graphical and tabular form (Gazdecki CENTURIES The inverse problem of EEG and clinical electroencephalography. Taganrog: Medic, 2000; Zhirmunskaya E.A. Clinical electroencephalography. M.: 1991; Max J. Methodology and technique of signal processing at the technical measurements. M.: Mir, 1983; Attributed R., L. Enochson Applied time series analysis. M.: Mir, 1982. Vol. 1, 2; Rusyns B.C., Grendel O.M., Boldyreva G.N., Wacker E.M. Biopotentials brain. The mathematical analysis. M.: Medicine, 1987).

The disadvantages of this method are:

1) when analyzing the power spectral amplitude harmonics are measured in millivolts recorded on the scalp voltage and translated in the mV squared, not understood by many researchers;

2) it is difficult to analyze nonlinear relationship (in this case, quadratic);

3) the power of the alpha rhythm does not demonstrate a direct correlation with pathological deviations and nosological forms of diseases of the brain;

4) encountered in pathology, visually defined on the graph, the "splitting" of the spectrum of the alpha rhythm, occurring at various mental illnesses, are described only qualitatively (modal, dimodolo, polymodal), which complicates the finding of correlation between the severity of a specified phenomenon and the clinical picture (Ivanov LB Applied take machine vision into what I electroencephalography. JSC "Antidoron", 2000).

The above method of studying changes in the alpha rhythm with mental illnesses not represent a complete picture of the disease the patient is qualitative and non-specific character not applicable for the purposes of nosological diagnosis of brain diseases, and do not accurately diagnose the severity of the pathological process.

The Method of determining the variance of the amplitude-frequency characteristics of the alpha rhythm of the brain in mental illness" has no analogues.

Object of the invention is the detection of quantitative changes of the spectrum of the alpha rhythm, pathognomonic organic lesions of the brain, allowing you to install their quantitative ratio, specific nosologic units in psychiatry.

The problem is solved by a method for determining the relative values that are a measure of the dispersion of the amplitude-frequency characteristics of the alpha rhythm, reflecting the structural content of the spectrum of its power in a particular patient, not showing individual features and changes specific to certain pathological conditions. Applying correlation analysis of the obtained quantities are produced normative parameters.

The essence of the proposed method for luchetta in the following.

Regular shooting of the background EEG on computer electroencephalograph 19 monopolar derivations according to the international system of electrodes "10-20", when the value of impedance of 10 ohms and less than the bandwidth of 0.3-50 Hz with a sampling rate of 256 Hz. As a reference used ear electrodes. The EEG registration is held at the position of the subject, seated in a comfortable chair, in a state of relaxed wakefulness. The EEG epoch length 20 s are subjected to a fast Fourier transformation using Windows Hannah in the band 3-30 Hz (step 0.25 Hz). Weekend review forms are formed by means of specialized WinEEG program, prepared in accordance with accepted standards of signal analysis, and represent graphs or tables of spectral power of the EEG at each lead in increments of 0.25 Hz.

Allocated a plot of duration of 20-25 seconds. On this plot is determined by the power spectrum in the whole range of radiation. On a standard chart (figure 1) is determined by the modal (maximum) power of the alpha rhythm (Mo). Calculates the power ratio of the modal (most pronounced) fluctuations of the alpha rhythm in any lead EEG to its total capacity in the same abstraction (α1). To clarify the existing violations is calculated ratio of the total is the second power of the alpha rhythm in the range of ±0.5 Hz from the modal (most pronounced) fluctuations to its total capacity (α 2). With this purpose to calculate (α1table capacity spectra rhythms exported from programs EEG, which is a rectangular matrix where the vertical are the names of standard EEG, and across - frequency oscillations from 0 to 30 Hz 0.25 Hz, is determined by the modal power (maximum power) fluctuations in any standard discharge (DoD) is in the range of the alpha rhythm (7-14 Hz). The same procedure can be carried out on graph spectra capacities rhythms provided by standard program EEG. Then define the total power of the alpha rhythm (M) by adding all the facilities in this abstraction in the alpha range (standard program EEG automatically provides this value in the summary table of power spectra). (α1) is calculated by the formula: Mo(1)/M×100%.

To calculate (α2must table capacity or capacities chart to select values capacities, which are located to the right and to the left of the modal values at 0.5 Hz (i.e. 2 to the right and to the left of the modal). All of these values, including modal, are summarized. The resulting value is divided Yes total power in this abstraction by the formula:

Where Mo is the modal power of the alpha rhythm (µv2),

M - Alova the power of the alpha rhythm.

The values obtained are compared with the target (table 1), obtained by statistical correlation analysis of clinical material, and a conclusion about the severity of the pathological process.

Table 2 - results of analysis of the clinical data produced by this method, which allows to clearly distinguish between the degree of brain damage.

The invention allows to introduce a quantitative parameter of the power spectrum of the alpha rhythm, reflecting the degree of brain lesions. Determination of the degree of change α1(%) and α2(%) allows to distinguish between normal and pathologically altered brain state, to the suggestion nosological facilities of these changes and to observe their dynamics.

This method was applied in GCOS OKB No. 1. BTW, Litvinova (Tver). In the process of learning 2235 electroencephalograms of patients and 115 healthy (control) were obtained from the data presented in table 2, confirming the proposed method of determining the variance of the amplitude-frequency characteristics of the alpha rhythm with mental illness.

Thus, there is a statistically significant correlation between the proposed indicators α1and α2and organic brain diseases.

Table 1
Values α1(%)Values α2(%)The degree of organic brain damage
Over 24> 67Normal EEG
Table 2
The degree of dispersion of the alpha rhythmα1α2,
the left hemispherethe right hemispherethe left hemisphereright on usaria
Control (M±m, %) p<0.01Patients (M±m, %) p<0.01Control (M±m, %) p<0.01Patients (M±m, %) p<0.01Control (M±m, %) p<0.01Patients (M±m, %) p<0.01Control (M±m, %) p<0.01Patients (M±m, %) p<0.01
Considerable0±0%12±0.1%13±0%12±0.1%48±0.7%39±0.5%45±1.3% 38±0.6%
n%115 (100%)2235 (100%)115 (100%)2235 (100%)115 (100%)2235 (100%)115 (100%)2235 (100%)

The method of determining the variance of the amplitude-frequency characteristics of the alpha rhythm of the brain in mental illness, including determination of the amplitude-frequency characteristics of the alpha rhythm on the basis of its power spectrum, wherein when recording standard EEG determine the total capacity of m is yuandong fluctuations in the range of the alpha rhythm in one of the leads and calculate the index α 1as the ratio of this power to the total power of all fluctuations in the alpha range and the same abstraction, then determine the value of the sum of power fluctuations, located on the right and left of the maximum power value ±0.5 Hz, including the maximum value, and calculate the indicator α2as the ratio of the determined amount of power to total power of all fluctuations in the alpha range in the same lead, and the severity of brain lesions detected by comparing the values α1and α2with normative values.


Same patents:

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to pediatrics and can be used in neurology, medical psychology and psychiatry. Clinical examination of children is carried out by complaints, anamnestic information and data of physical examination. Assessed are: symptoms of vegetative manifestations at the moment of examination and peculiarities of sensomotor reactions: weight and length of body at birth, gestation age, response to stimulation in children of first year of life, sleep in children of first year of life, EEG in children of early age, parasomnia, enuresis, meteosensitivity, headaches, vessel lability, vestibulopathy, peculiarities of motor sphere, feeding behaviour, skin manifestations, course of infectious and somatic diseases, menstrual disorders in adolescent girls, brain ultrasound examination. Connection of said disorders with predominant dysfunction of right or left brain hemispheres is determined.

EFFECT: method makes it possible to increase reliability of diagnostics, which is achieved due to taking into account vegetative reactions and disorders in child of first year of life.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to oncologic neurosurgery, neurology, psychiatry and functional diagnostics. Electroencephalographic examination is carried out. Level of coherent connection between pole-frontal and anterior temporal regions of cerebral cortex on the right is calculated in beta-range. If said parameter is higher than 0.52, Korsakoff's syndrome is diagnosed.

EFFECT: method makes it possible to increase reliability of Korsakoff's syndrome diagnostics.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to drug-free methods for activation of the cerebral verbal functions. Cerebral signals are recorded. Their duration is measured. A related verbal stimulus is established for the derived wave duration and has an effect on the patient. That is followed by measuring the duration of the next current wave through a time interval not less than the maximum duration of the used verbal stimuli, and the patient is exposed to the verbal stimulus corresponding to the current wave. According to the other version of implementing the method, the duration of the current wave is measured, and the corresponding verbal and contextually harmonised visual stimuli are set for the above duration. The patient is exposed thereto. That is followed by measuring the duration of the regular current wave through a time interval not less than the maximum duration of the used verbal stimuli, and the patient is exposed to the verbal and contextually harmonised visual stimuli corresponding to the current wave.

EFFECT: invention enables acceleration the process of verbal development in children.

1 dwg, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to neurology, psychiatry and pediatrics. Factors of perinatal pathology risk are determined: extragenital diseases of mother during pregnancy and labour, complications of pregnancy and labour, low gestational age, estimation by Apgar scale and compromised obstetric history. Also determined is presence of neurological malfunctions during 1-st year of life: syndromes of motor malfunctions, increased neuroreflex excitability, vegetative-visceral disorders, depression, retardation of physhomotor and speech development; and in older age - cerebrosthenic syndrome and syndrome of child dysphasia in structure of symptom complex of MBD, epileptiform activity by EEG. Results of questionnaire for MBD detection are evaluated in points. Prognostic coefficients F1 and F2 are calculated in discriminating equations. If F1 is higher than F2, favorable courseof MBD is predicted, if F1 is less than F2, unfavorable course of MBD is predicted.

EFFECT: method makes it possible to increase reliability of MBD course prediction.

2 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine. Electroencephalogram (EEG) is registered in background mode, spectrograms are calculated by means of wavelet conversion with Morlet mother function. Frequency ranges of leading EEG rhythms are determined by finding values of coordinate minimums by frequency of envelope projections of wavelet spectrograms on "amplitude-frequency" coordinate plane. In frequency ranges times Ti of spectrogram peak appearance are determined by values of positions of maximums on envelope projection of wavelet spectrograms. Frequencies Fi and amplitudes Ai of peaks of spectrograms, which correspond to values of times of their appearance in each frequency range, are determined. For each discretisation window with ΔT, ΔF parameters, obtained by fragmentation of duration T and frequency range F of EEG registration, values ΣAi of sums of amplitudes of spectrogram peaks are calculated. If frequency increases, range of frequencies of peaks expands, interhemispheric asymmetry of electric activity is detected, early stage of Parkinson disease is diagnosed.

EFFECT: method makes it possible to increase reliability of determination of early stage of PD.

4 cl, 9 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to functional diagnostics. Electroencephalogram (EEG) is registered, indices of averaged powers of spectra in background EEG registration in frequency range 8-13 Hz MI before 1up to 16 minute long HF impact and M2 after EHF impact consisting of 6-10 procedures are determined. Dynamics of ratios of said indices of powers M2/M1 presence of compensatory reserves of brain is determined. In case if ratios M2/M1, equal more than 1.2 are present, conclusion about positive dynamics of general functional state of brain an possibility of carrying out standard EHF therapy is made.

EFFECT: method extends arsenal of means for control over state of patient with encephalopathy in EHF therapy.

6 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to field of medical and psychophysiological diagnostics. Assessment of character of motor asymmetries - determination of degree of right-handedness - left-handedness by dominance of hand and leg, as well as sensor asymmetries - determination of leading eye and ear, is performed. Also calculated is coefficient of amplitude and frequency of mu-rhythm in central parts of left and right hemisphere, as ratio of difference of maximal and minimal values to their sum. Difference between maximal and minimal values is calculated within 3-second long interval. Dominating hemisphere of motor cortex by mu-rhythm is registered at the moment of alternate clenching right and left hand fist with application of sensomotor test by scheme: "Close eyes - make right fist - open eyes - undo the fist", "Close eyes - make left fist - open eyes - then undo the fist', during standard registration of electroencephalogram.

EFFECT: method extends arsenal of means for assessment of functional interhemispheric asymmetry.

9 dwg, 4 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to neuroinfections. Assessment of anamnesis data, virological indices, fever reaction and spotty-papular rash appearance is carried out. EEG is additionally registered in the first three days from the moment of admission, leukocyte index of intoxication, presence of mixed hypervirus infection are determined. If hypoxy-ischemic affection of central nervous system, spotty-papular rash on the body from the first day of disease with its "additional appearance" during 5-7 days, fever to 39-40°C during first 3-5 days are present in child's anamnesis, reduction of index of main physiological rhythm less than 30%, increased paroxysmal activity in form of diffuse sharp waves and flashes of slow activity with amplitude more than 100 mcV during 3 days or at least on one of these days are detected on EEG, value of leukocyte index is 0.2-3 conv.units, mixed hyperviruses together with varicella zoster virus, virus of type 6 herpes and/or type I herpes simplex virus are detected, risk of neurological complications is predicted.

EFFECT: method makes it possible to increase reliability of predicting risk of neurological complications in case of chicken pox in children.

3 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine and medical equipment, particularly to methods and apparatuses for scalp electric potential measurement. The apparatus comprises a number of sensors obtaining the initial measurement of a scalp electric potential through a hair-covering and an air contact area; a number of preamplifiers connected to one of the appropriate mentioned sensors. The contact area produces a high and variable coupling impedance of the source and the scalp. Each preamplifier contains a broadband high-impedance input and an active bias circuit generating input impedance more than 10 petaOhm over the range from 0.01 Hz to 400 Hz; a high-gain low-noise operating amplifier with the input impedance of 10 teraOhm; and a shielded feedback and bias circuit. The preamplifier is configured to have the input impedance substantially higher than the impedance produced by the source-sensor contact area. One version of the implementation of the method for scalp electric potential measurement, the preamplifier obtains the initial measurement of the scalp electric potential and forms a pre-intensified measurement of the scalp electric potential. The measurement is taken through the hair-covering and air. In the other version of the implementation of the method, an input signal of the initial scalp electric potential is obtained from the number of sensors to generate an appropriate number of channels. It is followed by the signal pre-amplification by the preamplifier with the high input impedance to form the pre-intensified measurement of the scalp electric potential. Then, a measurement mode is configured in a group containing a channel mode relative to a reference channel, a channel mode relative to a middle channel and a differential interchannel mode. Then, the pre-intensified measurement of the scalp electric potential is biased with maintaining the mentioned high input impedance; a channel gain is adjusted to differential obtaining of the channel signal. An additional stage providing the processed channel signal is suppressing radiofrequency interferences of the channel signal with maintaining adjustment of the gain and the phase; a common-mode of the channel signal is suppressed, and the band-pass channel filtration is provided. The processed channel signal is digitised to present a digital signal of the measurement of the scalp electric potential, characterising the mentioned input signal measured according to the mentioned chosen measurement mode.

EFFECT: use of the group of inventions allows more effective measurements of the scalp electric potential due to the preamplifiers, and allows reducing the need of exfoliating of the necrotic epithelial cells or application of abrasive or conducting gels.

27 cl, 11 dwg

FIELD: medicine.

SUBSTANCE: invention concerns medicine and medical technology. A patient is exposed to electrical stimulation generated by the 'simpaticor-01' apparatus. A one-element electrode is placed in a projection of cervical ganglia, while a multiple-element electrode - on a patient's neck. The exposure to the field is paused. A convulsive readiness threshold is assessed. Neurometabolic preparation dosage is specified in accordance with age, while anticolvulsants are dosed as per manufacturer's recommendations. Amplitude, frequency and length of the current pulse field, length of exposure and pauses are specified individually for each patient so that in the process of treatment and later on, the convulsive readiness threshold tends to decrease in the form of reducing a number of paroxysmal sharp and slow waves, as well as elimination of epileptoid activity.

EFFECT: method provides higher clinical effectiveness ensured by combining drug-induced therapy with electrical stimulation of the vegetative nervous system.

7 dwg, 1 tbl, 1 ex

FIELD: medicine, neurology, psychopathology, neurosurgery, neurophysiology, experimental neurobiology.

SUBSTANCE: one should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another.

EFFECT: higher accuracy of diagnostics.

5 dwg, 1 ex, 1 tbl

FIELD: medicine, neurology.

SUBSTANCE: one should establish neurological status, bioelectric cerebral activity, availability of perinatal and ORL pathology in patients, establish their gradations and numerical values followed by calculation of prognostic coefficients F1 and F2 by the following formulas: F1=-31,42+1,49·a1-2,44·a2+0,2·а3+1,63·a4+0,62·а5+3,75·a6+1,8·а7-3,23·a8-0,8·а9-1,32·а10+3,26·а11+8,92·a12-2,0·a13+3,88·а14+1,79·a15+0,83·a16-2,78·a17; F2=-27,58+1,43·a1+3,31·а2+0,08·а3+3,05·а4-0,27·а5+2,69·а6+3,11·а7-6,47·a8-6,55·a9+1,99·а10+5,25·а11+7,07·a12-0,47·a13+0,13·a14+4,04·a15-1,0·a16-1,14·а17, correspondingly, where a1 - patient's age, a2 - studying either at the hospital or polyclinic, a3 - duration of stationary treatment (in days), a4 - unconscious period, a5 - terms of hospitalization since the moment of light close craniocerebral trauma, a6 - smoking, a7 - alcohol misuse, a8 - arterial hypertension, a9 - amnesia, a10 - close craniocerebral trauma in anamnesis, a11 - psychoemotional tension, a12 - meteolability, a13 - cervical osteochondrosis, a14 - ORL pathology, a15 - availability of perinatal trauma in anamnesis with pronounced hypertension-hydrocephalic syndrome, a16 - availability of paroxysmal activity, a17 - availability and manifestation value of dysfunction of diencephalic structures. At F1 ≥ F2 on should predict the development of remote aftereffects in young people due to evaluating premorbid background of a patients at the moment of trauma.

EFFECT: higher reliability of prediction.

2 ex, 1 tbl

FIELD: medicine; medical engineering.

SUBSTANCE: method involves doing multi-channel recording of electroencephalogram and carrying out functional tests. Recording and storing rheoencephalograms is carried out additionally with multi-channel recording of electroencephalogram synchronously and in real time mode in carotid and vertebral arteries. Electroencephalograms and rheoencephalograms are visualized in single window with single time axis. Functional brain state is evaluated from synchronous changes of electroencephalograms, rheoencephalograms and electrocardiograms in response to functional test. The device has electrode unit 1 for recording bioelectric brain activity signals, electrode unit 2 for recording electric cardiac activity signals, current and potential electrode unit 3 for recording rheosignals, leads commutator 4, current rheosignal oscillator 5, synchronous rheosignal detector 6, multi-channel bioelectric brain activity signals amplifier 7, electrophysiological signal amplifier 8, demultiplexer 9, multi-channel rheosignal amplifier 10, multi-channel analog-to-digital converter 11, micro-computer 12 having galvanically isolated input/output port and personal computer 13 of standard configuration.

EFFECT: enhanced effectiveness of differential diagnosis-making.

11 cl, 6 dwg

FIELD: medicine; medical engineering.

SUBSTANCE: method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2.

EFFECT: wide range of functional applications.

15 cl, 10 dwg

FIELD: medicine, psychiatry.

SUBSTANCE: one should conduct EEG-testing to detect total value of the indices of spectral power or percentage spectral power of delta- and teta-rhythms due to spectrometric technique in frontal, parietal, central and temporal areas both before and during emotional-negative loading when visual emotionally negative stimuli are presented followed by their imaginary reproduction. In case of higher indices to visual stimuli being above 15% against the background one should diagnose epilepsy. The method enables to increase the number of diagnostic means, increase accuracy and objectivity in predicting epilepsy with polymorphic paroxysms at dissociation of clinical and EEG-values.

EFFECT: higher efficiency of diagnostics.

1 ex, 1 tbl

FIELD: medicine, neurophysiology.

SUBSTANCE: one should carry out EEG survey to detect spectrometrically the index of full range if alpha-rhythm both before and after therapy. Moreover, power index of full range of alpha-rhythm and the index of 9-10 Hz-strip's spectral power should be detected in occipital cerebral areas. One should calculate the value of the ratio of the index of 9-10 Hz-strip's spectral power to the index of full range of alpha-rhythm and at the increase of this value by 20% against the background it is possible to evaluate positive result of therapy. The method increases the number of diagnostic means applied in evaluating therapeutic efficiency in the field of neurophysiology.

EFFECT: higher efficiency of evaluation.

1 ex

FIELD: medicine, neurology.

SUBSTANCE: method involves carrying out the standard vascular and nootropic therapy. Diazepam is administrated under EEG control with the infusion rate that is calculated by the following formula: y = 0.0015x - 0.025 wherein y is the rate of diazepam administration, mg/h; x is an average EEG amplitude, mcV. Method provides enhancing the effectiveness of treatment of patients. Invention can be used for treatment of patients in critical severe period of ischemic insult.

EFFECT: enhanced effectiveness of treatment.

2 tbl, 1 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: method involves selecting signals showing patient consciousness level and following evoked auditory potentials as responses to repeating acoustic stimuli, applying autoregression model with exogenous input signal and calculating AAI index showing anesthesia depth next to it.

EFFECT: quick tracing of unconscious to conscious state and vice versa; high accuracy of measurements.

9 cl, 3 dwg

FIELD: medicine; experimental and medicinal physiology.

SUBSTANCE: device can be used for controlling changes in functional condition of central nervous system. Device has receiving electrodes, unit for reading electroencephalograms out, analog-to-digital converter and inductor. Low noise amplifier, narrow band filter linear array which can be program-tuned, sample and store unit, online memory, microcontroller provided with controlled permanent storage, liquid-crystal indicator provided with external control unit are introduced into device additionally. Receiving electrodes are fastened to top part of patient's head. Outputs of electrodes are connected with narrow band filters linear array through electroencephalograph. Output of linear array is connected with input of input unit which has output connected with input of analog-to-digital converter. First bus of analog-to-digital converter is connected with online storage. Recording/reading bus of microcontroller is connected with control input of input unit and its starting bus is connected with address input of online storage. Third control bus is connected with narrow band filters linear array. Second control bus is connected with liquid-crystal indicator. Output bus is connected with inductor. External control (keyboard) of first control bus is connected with microcontroller. Output of online storage is connected with data input of microcontroller through 12-digit second data bus. Efficiency of influence is improved due to getting specific directed influence being based onto general technological transparency of processing of human brain's signals and strictly specific influence based on the condition of better stimulation.

EFFECT: increased efficiency.

3 cl, 1 dwg, 1 tbl

FIELD: medicine, neurology, professional pathology.

SUBSTANCE: one should carry out either biochemical blood testing and electroencephalography or SMIL test, or ultrasound dopplerography of the main cranial arteries, rheoencephalography (REG) to detect the volume of cerebral circulation and hypercapnic loading and their digital values. Then it is necessary to calculate diagnostic coefficients F by the following formulas: Fb/e=6.3-0.16·a1+0.12·a2-1·a3+0.2·a4, or FSMIL=9.6+0.16·a5-0.11·a6-0.14·a7+0.07·a8, or Fhem=48.6-0.04·a9+0.15·a10+13.7·a11-0.02·a12+24.7·a13, where Fb/e -diagnostic coefficient for biochemical blood testings and EEG; FSMIL - diagnostic coefficient for SMIL test; Fhem - diagnostic coefficient for hemodynamic testing; 6.3; 9.6 and 48.6 - constants; a1 - the level of vitamin C in blood; a2 - δ-index by EEG; a3 - atherogenicity index; a4 - the level of α-proteides in blood; a5 - scale 3 value by SMIL; a6 - scale K value by SMIL; a7 - scale 5 value by SMIL; a8 - scale 7 value by SMIL; a9 - the level of volumetric cerebral circulation; a10 - the value of linear circulatory rate along total carotid artery, a11 - the value of resistive index along total carotid artery; a12 - the value for the tonicity of cerebral vessels at carrying out hypercapnic sampling by REG; a13 - the value for the intensity of cerebral circulation in frontal-mastoid deviation by REG. At F value being above the constant one should diagnose toxic encephalopathy, at F value being below the constant - discirculatory encephalopathy due to applying informative values.

EFFECT: higher accuracy of diagnostics.

6 ex, 1 tbl