Method of determining dispersion of amplitude-frequency characteristics of brain alpha-rhythm in case of mental illnesses. RU patent 2506044.
| Method of diagnosing congenital dysfunctions of brain hemispheres in children / 2494680 Invention relates to medicine, namely to pediatrics and can be used in neurology, medical psychology and psychiatry. Clinical examination of children is carried out by complaints, anamnestic information and data of physical examination. Assessed are: symptoms of vegetative manifestations at the moment of examination and peculiarities of sensomotor reactions: weight and length of body at birth, gestation age, response to stimulation in children of first year of life, sleep in children of first year of life, EEG in children of early age, parasomnia, enuresis, meteosensitivity, headaches, vessel lability, vestibulopathy, peculiarities of motor sphere, feeding behaviour, skin manifestations, course of infectious and somatic diseases, menstrual disorders in adolescent girls, brain ultrasound examination. Connection of said disorders with predominant dysfunction of right or left brain hemispheres is determined. |
| Method of diagnosing korsakoff's syndrome in patients with tumours of basal-diencephalic localisation by data of electroencephalographic examination / 2493771 Invention relates to field of medicine, namely to oncologic neurosurgery, neurology, psychiatry and functional diagnostics. Electroencephalographic examination is carried out. Level of coherent connection between pole-frontal and anterior temporal regions of cerebral cortex on the right is calculated in beta-range. If said parameter is higher than 0.52, Korsakoff's syndrome is diagnosed. |
 Method for activation of cerebral verbal functions / 2492839Invention refers to medicine, namely to drug-free methods for activation of the cerebral verbal functions. Cerebral signals are recorded. Their duration is measured. A related verbal stimulus is established for the derived wave duration and has an effect on the patient. That is followed by measuring the duration of the next current wave through a time interval not less than the maximum duration of the used verbal stimuli, and the patient is exposed to the verbal stimulus corresponding to the current wave. According to the other version of implementing the method, the duration of the current wave is measured, and the corresponding verbal and contextually harmonised visual stimuli are set for the above duration. The patient is exposed thereto. That is followed by measuring the duration of the regular current wave through a time interval not less than the maximum duration of the used verbal stimuli, and the patient is exposed to the verbal and contextually harmonised visual stimuli corresponding to the current wave. |
 Method of predicting version of minimal brain dysfunction (mbd) course / 2489965Invention relates to medicine, namely to neurology, psychiatry and pediatrics. Factors of perinatal pathology risk are determined: extragenital diseases of mother during pregnancy and labour, complications of pregnancy and labour, low gestational age, estimation by Apgar scale and compromised obstetric history. Also determined is presence of neurological malfunctions during 1-st year of life: syndromes of motor malfunctions, increased neuroreflex excitability, vegetative-visceral disorders, depression, retardation of physhomotor and speech development; and in older age - cerebrosthenic syndrome and syndrome of child dysphasia in structure of symptom complex of MBD, epileptiform activity by EEG. Results of questionnaire for MBD detection are evaluated in points. Prognostic coefficients F1 and F2 are calculated in discriminating equations. If F1 is higher than F2, favorable course of MBD is predicted, if F1 is less than F2, unfavorable course of MBD is predicted. |
 Method of early encephalographic diagnostics of parkinson disease / 2484766Invention relates to medicine. Electroencephalogram (EEG) is registered in background mode, spectrograms are calculated by means of wavelet conversion with Morlet mother function. Frequency ranges of leading EEG rhythms are determined by finding values of coordinate minimums by frequency of envelope projections of wavelet spectrograms on "amplitude-frequency" coordinate plane. In frequency ranges times Ti of spectrogram peak appearance are determined by values of positions of maximums on envelope projection of wavelet spectrograms. Frequencies Fi and amplitudes Ai of peaks of spectrograms, which correspond to values of times of their appearance in each frequency range, are determined. For each discretisation window with ΔT, ΔF parameters, obtained by fragmentation of duration T and frequency range F of EEG registration, values ΣAi of sums of amplitudes of spectrogram peaks are calculated. If frequency increases, range of frequencies of peaks expands, interhemispheric asymmetry of electric activity is detected, early stage of Parkinson disease is diagnosed. |
 Method of controlling state of patient with encelophalopathy in ehf therapy / 2484765Invention relates to field of medicine, namely to functional diagnostics. Electroencephalogram (EEG) is registered, indices of averaged powers of spectra in background EEG registration in frequency range 8-13 Hz MI before 1up to 16 minute long HF impact and M2 after EHF impact consisting of 6-10 procedures are determined. Dynamics of ratios of said indices of powers M2/M1 presence of compensatory reserves of brain is determined. In case if ratios M2/M1, equal more than 1.2 are present, conclusion about positive dynamics of general functional state of brain an possibility of carrying out standard EHF therapy is made. |
 Method of diagnosing functional interhemispheric asymmetry in right-handed and left-handed people / 2483672Invention relates to medicine, in particular to field of medical and psychophysiological diagnostics. Assessment of character of motor asymmetries - determination of degree of right-handedness - left-handedness by dominance of hand and leg, as well as sensor asymmetries - determination of leading eye and ear, is performed. Also calculated is coefficient of amplitude and frequency of mu-rhythm in central parts of left and right hemisphere, as ratio of difference of maximal and minimal values to their sum. Difference between maximal and minimal values is calculated within 3-second long interval. Dominating hemisphere of motor cortex by mu-rhythm is registered at the moment of alternate clenching right and left hand fist with application of sensomotor test by scheme: "Close eyes - make right fist - open eyes - undo the fist", "Close eyes - make left fist - open eyes - then undo the fist', during standard registration of electroencephalogram. |
| Method of predicting risk of neurological complications in case of chicken pox in children / 2481786 Invention relates to field of medicine, namely to neuroinfections. Assessment of anamnesis data, virological indices, fever reaction and spotty-papular rash appearance is carried out. EEG is additionally registered in the first three days from the moment of admission, leukocyte index of intoxication, presence of mixed hypervirus infection are determined. If hypoxy-ischemic affection of central nervous system, spotty-papular rash on the body from the first day of disease with its "additional appearance" during 5-7 days, fever to 39-40°C during first 3-5 days are present in child's anamnesis, reduction of index of main physiological rhythm less than 30%, increased paroxysmal activity in form of diffuse sharp waves and flashes of slow activity with amplitude more than 100 mcV during 3 days or at least on one of these days are detected on EEG, value of leukocyte index is 0.2-3 conv.units, mixed hyperviruses together with varicella zoster virus, virus of type 6 herpes and/or type I herpes simplex virus are detected, risk of neurological complications is predicted. |
 Method and apparatus for scalp electric potential measurement / 2479252Group of inventions refers to medicine and medical equipment, particularly to methods and apparatuses for scalp electric potential measurement. The apparatus comprises a number of sensors obtaining the initial measurement of a scalp electric potential through a hair-covering and an air contact area; a number of preamplifiers connected to one of the appropriate mentioned sensors. The contact area produces a high and variable coupling impedance of the source and the scalp. Each preamplifier contains a broadband high-impedance input and an active bias circuit generating input impedance more than 10 petaOhm over the range from 0.01 Hz to 400 Hz; a high-gain low-noise operating amplifier with the input impedance of 10 teraOhm; and a shielded feedback and bias circuit. The preamplifier is configured to have the input impedance substantially higher than the impedance produced by the source-sensor contact area. One version of the implementation of the method for scalp electric potential measurement, the preamplifier obtains the initial measurement of the scalp electric potential and forms a pre-intensified measurement of the scalp electric potential. The measurement is taken through the hair-covering and air. In the other version of the implementation of the method, an input signal of the initial scalp electric potential is obtained from the number of sensors to generate an appropriate number of channels. It is followed by the signal pre-amplification by the preamplifier with the high input impedance to form the pre-intensified measurement of the scalp electric potential. Then, a measurement mode is configured in a group containing a channel mode relative to a reference channel, a channel mode relative to a middle channel and a differential interchannel mode. Then, the pre-intensified measurement of the scalp electric potential is biased with maintaining the mentioned high input impedance; a channel gain is adjusted to differential obtaining of the channel signal. An additional stage providing the processed channel signal is suppressing radiofrequency interferences of the channel signal with maintaining adjustment of the gain and the phase; a common-mode of the channel signal is suppressed, and the band-pass channel filtration is provided. The processed channel signal is digitised to present a digital signal of the measurement of the scalp electric potential, characterising the mentioned input signal measured according to the mentioned chosen measurement mode. |
 Method of treating hyperkinetic disorder in children / 2476250Invention concerns medicine and medical technology. A patient is exposed to electrical stimulation generated by the 'simpaticor-01' apparatus. A one-element electrode is placed in a projection of cervical ganglia, while a multiple-element electrode - on a patient's neck. The exposure to the field is paused. A convulsive readiness threshold is assessed. Neurometabolic preparation dosage is specified in accordance with age, while anticolvulsants are dosed as per manufacturer's recommendations. Amplitude, frequency and length of the current pulse field, length of exposure and pauses are specified individually for each patient so that in the process of treatment and later on, the convulsive readiness threshold tends to decrease in the form of reducing a number of paroxysmal sharp and slow waves, as well as elimination of epileptoid activity. |
 Method for detecting both functional and metabolic state of nervous tissue / 2245673One should simultaneously register electroencephalogram (EEG) to detect the level of constant potential (LCP). At LCP negativization and increased EEG power one should detect depolarizational activation of neurons and enhanced metabolism. At LCP negativization and decreased EEG power - depolarized inhibition of neurons and metabolism suppression. At LCP positivation and increased EEG power - either repolarized or hyperpolarized activation of neurons and enhanced metabolism. At LCP positivation and decreased EEG power - hyperpolarized suppression of neurons and decreased metabolism of nervous tissue. The method enables to correctly detect therapeutic tactics due to simultaneous LCP and EEG registration that enables to differentiate transition from one functional and metabolic state into another. |
 Method for predicting remote aftereffects of light close craniocerebral trauma in young people / 2246252One should establish neurological status, bioelectric cerebral activity, availability of perinatal and ORL pathology in patients, establish their gradations and numerical values followed by calculation of prognostic coefficients F1 and F2 by the following formulas: F1=-31,42+1,49·a1-2,44·a2+0,2·а3+1,63·a4+0,62·а5+3,75·a6+1,8·а7-3,23·a8-0,8·а9-1,32·а10+3,26·а11+8,92·a12-2,0·a13+3,88·а14+1,79·a15+0,83·a16-2,78·a17; F2=-27,58+1,43·a1+3,31·а2+0,08·а3+3,05·а4-0,27·а5+2,69·а6+3,11·а7-6,47·a8-6,55·a9+1,99·а10+5,25·а11+7,07·a12-0,47·a13+0,13·a14+4,04·a15-1,0·a16-1,14·а17, correspondingly, where a1 - patient's age, a2 - studying either at the hospital or polyclinic, a3 - duration of stationary treatment (in days), a4 - unconscious period, a5 - terms of hospitalization since the moment of light close craniocerebral trauma, a6 - smoking, a7 - alcohol misuse, a8 - arterial hypertension, a9 - amnesia, a10 - close craniocerebral trauma in anamnesis, a11 - psychoemotional tension, a12 - meteolability, a13 - cervical osteochondrosis, a14 - ORL pathology, a15 - availability of perinatal trauma in anamnesis with pronounced hypertension-hydrocephalic syndrome, a16 - availability of paroxysmal activity, a17 - availability and manifestation value of dysfunction of diencephalic structures. At F1 ≥ F2 on should predict the development of remote aftereffects in young people due to evaluating premorbid background of a patients at the moment of trauma. |
 Method and device for studying functional state of brain / 2248745Method involves doing multi-channel recording of electroencephalogram and carrying out functional tests. Recording and storing rheoencephalograms is carried out additionally with multi-channel recording of electroencephalogram synchronously and in real time mode in carotid and vertebral arteries. Electroencephalograms and rheoencephalograms are visualized in single window with single time axis. Functional brain state is evaluated from synchronous changes of electroencephalograms, rheoencephalograms and electrocardiograms in response to functional test. The device has electrode unit 1 for recording bioelectric brain activity signals, electrode unit 2 for recording electric cardiac activity signals, current and potential electrode unit 3 for recording rheosignals, leads commutator 4, current rheosignal oscillator 5, synchronous rheosignal detector 6, multi-channel bioelectric brain activity signals amplifier 7, electrophysiological signal amplifier 8, demultiplexer 9, multi-channel rheosignal amplifier 10, multi-channel analog-to-digital converter 11, micro-computer 12 having galvanically isolated input/output port and personal computer 13 of standard configuration. |
 Method and device for studying functional state of brain and method for measuring subelectrode resistance / 2252692Method involves recording multichannel electroencephalogram, electrocardiogram record and carrying out functional test and computer analysis of electrophysiological signals synchronously with multichannel record of electroencephalogram and electrocardiogram in real time mode. Superslow brain activity is recorded, carotid and spinal artery pools rheoelectroencephalogram is recorded and photopletysmogram of fingers and/or toes is built and subelectrode resistance of electrodes for recording bioelectrical cerebral activity is measured. Physiological values of bioelectrical cerebral activity are calculated and visualized in integrated cardiac cycle time scale as absolute and relative values of alpha-activity, pathological slow wave activity in delta and theta wave bandwidth. Cerebral metabolism activity dynamics level values are calculated and visualized at constant potential level. Heart beat rate is determined from electrocardiogram, pulsating blood-filling of cerebral blood vessels are determined from rheological indices data. Peripheral blood vessel resistance level, peripheral blood vessel tonus are determined as peripheral photoplethysmogram pulsation amplitude, large blood vessel tonus is determined from pulse wave propagation time data beginning from Q-tooth signal of electrocardiogram to the beginning of systolic wave of peripheral photoplethysmogram. Postcapillary venular blood vessels tonus is determined from constant photoplethysmogram component. Functional brain state is determined from dynamic changes of physiological values before during and after the functional test. Device for evaluating functional brain state has in series connected multichannel analog-to-digital converter, microcomputer having galvanically isolated input/output ports and PC of standard configuration and electrode unit for reading bioelectric cerebral activity signals connected to multichannel bioelectric cerebral activity signals amplifier. Current and potential electrode unit for recording rheosignals, multichannel rheosignals amplifier, current rheosignals generator and synchronous rheosignals detector are available. The device additionally has two-frequency high precision current generator, master input of which is connected to microcomputer. The first output group is connected to working electrodes and the second one is connected to reference electrodes of electrode unit for reading bioelectrical cerebral activity signals. Lead switch is available with its first input group being connected to potential electrodes of current and potential electrodes unit for recording rheosignals. The second group of inputs is connected to outputs of current rheosignals oscillator. The first group of outputs is connected to current electrodes of current and potential electrodes unit for recording rheosignals. The second group of outputs is connected to inputs of synchronous detector of rheosignals. Demultiplexer input is connected to output of synchronous detector of rheosignals and its outputs are connected to multichannel rheosignals amplifier inputs. Outputs of multichannel bioelectrical cerebral activity signals amplifier, multichannel rheosignals amplifier and electrophysiological signal amplifier are connected to corresponding inputs of multichannel analog-to-digital converter. Microcomputer outputs are connected to control input of lead switch, control input of multichannel demultiplexer, control input of multichannel analog-to-digital converter and synchronization inputs of current rheosignals oscillator and synchronous detector of rheosignals. To measure subelectrode resistance, a signal from narrow bandwidth current generator of frequency f1 exceeding the upper frequency fup of signals under recording is supplied. A signal from narrow bandwidth current generator of frequency f2≠ f1>fup is supplied to reference electrode. Voltages are selected and measured at output of each amplifier with frequencies of f1, f2 - Uf1 and Uf2 using narrow bandwidth filtering. Subelectrode resistance of each working electrode is determined from formula Zj=Ujf1 :(Jf1xKj), where Zj is the subelectrode resistance of j-th electrode, Ujf1 is the voltage at output from j-th amplifier with frequency of f1, Kj is the amplification coefficient of the j-th amplifier. Subelectrode resistance of reference electrode is determined from formula ZA=Ujf2 :(Jf2xKj), where ZA is the subelectrode resistance of reference electrode, Ujf2 is the voltage at output from j-th amplifier with frequency of f2, Jf2 is the voltage of narrow bandwidth current oscillator with frequency of f2. |
| Method for predicting epilepsy with polymorphic paroxysms / 2254052 One should conduct EEG-testing to detect total value of the indices of spectral power or percentage spectral power of delta- and teta-rhythms due to spectrometric technique in frontal, parietal, central and temporal areas both before and during emotional-negative loading when visual emotionally negative stimuli are presented followed by their imaginary reproduction. In case of higher indices to visual stimuli being above 15% against the background one should diagnose epilepsy. The method enables to increase the number of diagnostic means, increase accuracy and objectivity in predicting epilepsy with polymorphic paroxysms at dissociation of clinical and EEG-values. |
| Method for evaluating therapeutic efficiency of cognitive disorders with nootropic preparations / 2254053 One should carry out EEG survey to detect spectrometrically the index of full range if alpha-rhythm both before and after therapy. Moreover, power index of full range of alpha-rhythm and the index of 9-10 Hz-strip's spectral power should be detected in occipital cerebral areas. One should calculate the value of the ratio of the index of 9-10 Hz-strip's spectral power to the index of full range of alpha-rhythm and at the increase of this value by 20% against the background it is possible to evaluate positive result of therapy. The method increases the number of diagnostic means applied in evaluating therapeutic efficiency in the field of neurophysiology. |
 Method for treatment of ischemic insult in critical severe period / 2255739Method involves carrying out the standard vascular and nootropic therapy. Diazepam is administrated under EEG control with the infusion rate that is calculated by the following formula: y = 0.0015x - 0.025 wherein y is the rate of diazepam administration, mg/h; x is an average EEG amplitude, mcV. Method provides enhancing the effectiveness of treatment of patients. Invention can be used for treatment of patients in critical severe period of ischemic insult. |
 Evoked auditory potential monitoring / 2262294Method involves selecting signals showing patient consciousness level and following evoked auditory potentials as responses to repeating acoustic stimuli, applying autoregression model with exogenous input signal and calculating AAI index showing anesthesia depth next to it. |
 Device for normalizing rhythms of human brain / 2268642Device can be used for controlling changes in functional condition of central nervous system. Device has receiving electrodes, unit for reading electroencephalograms out, analog-to-digital converter and inductor. Low noise amplifier, narrow band filter linear array which can be program-tuned, sample and store unit, online memory, microcontroller provided with controlled permanent storage, liquid-crystal indicator provided with external control unit are introduced into device additionally. Receiving electrodes are fastened to top part of patient's head. Outputs of electrodes are connected with narrow band filters linear array through electroencephalograph. Output of linear array is connected with input of input unit which has output connected with input of analog-to-digital converter. First bus of analog-to-digital converter is connected with online storage. Recording/reading bus of microcontroller is connected with control input of input unit and its starting bus is connected with address input of online storage. Third control bus is connected with narrow band filters linear array. Second control bus is connected with liquid-crystal indicator. Output bus is connected with inductor. External control (keyboard) of first control bus is connected with microcontroller. Output of online storage is connected with data input of microcontroller through 12-digit second data bus. Efficiency of influence is improved due to getting specific directed influence being based onto general technological transparency of processing of human brain's signals and strictly specific influence based on the condition of better stimulation. |
| Method for differential diagnostics of toxic encephalopathy against the impact of the complex of toxic substances and disculatory (vascular) encephalopathy / 2271143 One should carry out either biochemical blood testing and electroencephalography or SMIL test, or ultrasound dopplerography of the main cranial arteries, rheoencephalography (REG) to detect the volume of cerebral circulation and hypercapnic loading and their digital values. Then it is necessary to calculate diagnostic coefficients F by the following formulas: Fb/e=6.3-0.16·a1+0.12·a2-1·a3+0.2·a4, or FSMIL=9.6+0.16·a5-0.11·a6-0.14·a7+0.07·a8, or Fhem=48.6-0.04·a9+0.15·a10+13.7·a11-0.02·a12+24.7·a13, where Fb/e -diagnostic coefficient for biochemical blood testings and EEG; FSMIL - diagnostic coefficient for SMIL test; Fhem - diagnostic coefficient for hemodynamic testing; 6.3; 9.6 and 48.6 - constants; a1 - the level of vitamin C in blood; a2 - δ-index by EEG; a3 - atherogenicity index; a4 - the level of α-proteides in blood; a5 - scale 3 value by SMIL; a6 - scale K value by SMIL; a7 - scale 5 value by SMIL; a8 - scale 7 value by SMIL; a9 - the level of volumetric cerebral circulation; a10 - the value of linear circulatory rate along total carotid artery, a11 - the value of resistive index along total carotid artery; a12 - the value for the tonicity of cerebral vessels at carrying out hypercapnic sampling by REG; a13 - the value for the intensity of cerebral circulation in frontal-mastoid deviation by REG. At F value being above the constant one should diagnose toxic encephalopathy, at F value being below the constant - discirculatory encephalopathy due to applying informative values. |
FIELD: medicine.
SUBSTANCE: invention relates to field of medicine, namely to neurophysiological methods of examination. Registration of EEG is carried out, total power of modal fluctuation in alpha-rhythm range in one of leads is determined and FRα1 index is calculated as ration of said power to total power of all alpha range fluctuations in the same lead. Value of the sum of power of fluctuations, located ±0.5 Hz on the right and on the left from maximal power value, including maximal value, is determined, and FRα2 index is calculated as ratio of the obtained sum of power to total power of all fluctuations of alpha-range in the same lead. Intensity of brain affection is determined by comparison of obtained FRα1 and FRα2 values with standard values.
EFFECT: method makes it possible to determined quantitative ratio of alpha-rhythm, characteristic of separate nosologic units in psychiatry.
2 tbl, 1 dwg
The invention relates to the medical field of application, in particular to the neurophysiological research methods.
Known method for determining the spectral radiation power of alpha-rhythm as its amplitude-frequency characteristics in conducting brain. A mathematical basis of the amplitude-frequency analysis is the Fourier transform takes many forms depending on the type of analyzed signals. In common is the assumption that the studied processes (signals) consist of a certain number of (possibly infinite) sinusoidal and/or components (harmonics) consistently increasing number of frequencies. Fourier transform decomposes the signal on a number of harmonic components without any loss of information (if arithmetically add up all the harmonics, it will turn again the original signal). Each harmonic is determined by three parameters: amplitude of the initial phase and frequency. The dependence of the amplitude and phase of the harmonics of the frequencies is called the spectrum. The power spectrum P(i)=f(f (i ) is the amplitude spectrum of the squared P(i)=A (i) 2 . In practice, spectral analysis of EEG using inline in computer programs. Search the power spectrum of a particular frequency radiation can be printed in graphical or tabular form ( CENTURIES Inverse problem of EEG and clinical electroencephalography. Taganrog: the Physician, 2000; E.A. Clinical electroencephalography. M: 1991; Max J. technique of signal processing in technical measurements. M: Mir, 1983; Carried R., Enochson HP Applied time series analysis. M: Mir, 1982. Vol. 1, 2; Rusyns B.C., O.M., Boldyreva G.N., Wacker EM brain Biopotentials. Mathematical analysis. M: Medicine, 1987).
Disadvantages of this method are:
1) in the analysis of power spectral amplitude of the harmonics are measured in the mV registered on the scalp, skull voltage and translated in the mV squared, not understood by many researchers;
2) it is difficult to analyze the nonlinear relationship (in this case, the quadratic);
3) capacity of the alpha-rhythm shows no direct correlation with pathological deviations and nosological forms of diseases of the brain;
4) found in pathology, visually identified on schedule, «the splitting of the spectrum of alpha-rhythm encountered in various mental illnesses, only describes qualitatively (, , )that makes it difficult to identify the correlation between the severity of the specified phenomenon and a clinical picture (Ivanov .Б. Applied computer electroencephalography. AOZT «», 2000).
The above way of change of alpha rhythm with mental illness does not represent the full picture of a patient's illness, is qualitative and nonspecific, not applicable for the purposes of the nosological diagnosis of brain diseases, and may not accurately diagnose the degree of severity of the pathological process.
Method of determining the dispersion of amplitude-frequency characteristics of alpha-rhythm of the brain in mental illness» has no analogues.
The objective of the invention is to identify quantitative changes of a spectrum of alpha-rhythm pathognomonic organic lesions of the brain, to establish their quantitative ratio, typical for particular nosological units in psychiatry.
The problem is solved by the method of determination of relative values, which are a measure of dispersion of amplitude-frequency characteristics of alpha rhythm, reflecting the structural content of the spectrum of its power in a particular patient, showing not its individual features and changes specific to certain pathological conditions. Using correlation analysis of the quantitative values, and develop standard indicators.
The essence of the proposed method consists in the following.
Is the standard shooting background EEG on computer in 19 monopolar leads according to the international system of electrodes «10-20»when the value of the impedance 10 kOhm and less bandwidth of 0.3-50 Hz with a sampling rate of 256 Hz. As a reference used ear electrodes. Registration of EEG is held with the position of the subject, sitting in a chair in the state of relaxed wakefulness. Era EEG length of 20 seconds are a fast Fourier transformation using Windows Hannah in the band 3-30 Hz (step 0.25 Hz). The forms of analysis are formed by means of specialized program WinEEG prepared in accordance with accepted standards of signal analysis and represent graphs or tables EEG spectral power at each lead with a step of 0.25 Hz.
Allocated plot duration of 20-25 seconds. This sector is determined by the power spectrum in the whole range of radiation. On the standard chart (figure 1) is determined by modal (maximum) capacity of the alpha-rhythm (MoE). The computation of the power ratio of the modal (most pronounced) oscillations of alpha rhythm in any lead of the EEG to its total capacity in the same lead (α 1 ). To define existing violations calculated the ratio of total capacity of the alpha-rhythm in a range of 0.5 Hz from the modal (most pronounced) fluctuations to its total capacity (α 2 ). With this purpose in calculations (α 1 ) from the table capacities spectra rhythms exported from the program EEG, which is a rectangular matrix, where the vertical axis names of standard EEG, and horizontal frequency from 0 up to 30 Hz with 0.25 Hz, determined by the power of the modal (maximum capacity) fluctuations in any standard lead (Mo) in the range of alpha rhythm (7-14 Hz). The same procedure can be performed on the chart of the power spectra of rhythms, provided by the standard programme of the EEG. Then determined the total capacity of the alpha-rhythm (M) by adding all the facilities in the lead in the alpha range (standard program EEG automatically provides this value in the summary table capacities spectra). (α 1 ) is calculated by the formula: Mo(1)/M x 100%.
To calculate (α 2 ) it is necessary in the table capacities or graph capacity to allocate values of powers, which are to the right and to the left of the modal value of 0.5 Hz (ie 2 to the right and to the left of the modal). All of these values, including modal, are summarized. The resulting value is divided Yes total power in this abduction by the formula:
Where Mo - modal power of alpha rhythm (MACs 2 ),
M - gross power of the alpha rhythm.
The values obtained are compared with the target (table 1), obtained by statistical correlated analysis of clinical material, and the conclusion is made about the severity of the pathological process.
Table 2 - the result of the analysis of clinical data produced by this method allows to clearly distinguish between the brain lesions.
The invention allows to introduce a quantitative parameter of the power spectrum of the alpha rhythm, reflecting a degree of brain lesions. Determination of the degree of changes α 1 (%) and α 2 (%) allows to differentiate normal and pathologically altered condition of the brain, to assume the nosology of these changes and observe them in dynamics.
This method was applied in Б №1. M. Litvinova (Tver). In the process of studying 2235 electroencephalograms patients and 115 healthy people (control) were obtained the data presented in table 2, confirming the proposed method of determining the dispersion of amplitude-frequency characteristics of alpha-rhythm with mental illnesses.
Thus, there is a statistically significant correlation between the proposed indicators α 1 and α 2 and organic diseases of the brain.
Table 1Values α 1 (%)
Values α 2 (%)
The degree of organic brain
More than 24
More than 67
Normal EEG
18-21 61-66 Easy 15-18 51-60 Moderate 5-14 15-50Considerable
Table 2The degree of dispersion of the alpha rhythm
α 1α 2 ,
left hemisphere
right hemisphere
left hemisphere
right hemisphere
Control (Pitch m, %) p<0.01
Patients (Pitch m, %) p<0.01
Control (Pitch m, %) p<0.01
Patients (Pitch m, %) p<0.01
Control (Pitch m, %) p<0.01
Patients (Pitch m, %) p<0.01
Control (Pitch m, %) p<0.01
Patients (Pitch m, %) p<0.01
Minimum29 to -1%
27±0.3% 29±1.1% 27±0.3% 75±1.4%75 ą0.4%
75±1.7% 75±0.5% n,% 60(52%) 171(8%) 63(55%) 405(18%) 69(60%) 387(17%) 76(75%) 637(29%) Easy21 ą0.4%
21±0.1%21 ą0.4%
21±0.1%63 ą0.4%
64±0.1% 64±0.5% 63±0.1% n,% 49(43%) 679(30%) 42(37%) 694(31%) 29(25%) 579(26%) 32(28%) 515(23%)Mild-Naya
17±0.2% 17±0.1% 17±0.2% 17±0.1% 56±0.8% 56±0.2%56 ą0.4%
56±0.2% n,% 6(5%) 679(30%) 9(8%) 561(25%) 13(11%) 437(20%) 5(4%) 388(17%)Significant insignificant
0±0% 12±0.1% 13±0% 12±0.1% 48±0.7% 39±0.5% 45±1.3%38 ą0.6%
n,% (0%) 606(27%) 1(1%) 575(26%) 4(3%) 832(37%) 2(2%) 695(31%) Just 25±1.4% 18±0.3% 25±1.6%19 ą0.4%
69±2.7%55 to -1%
71±2.5% 58±1.1% n,%115 (100%)
2235 (100%)
115 (100%)
2235 (100%)
115 (100%)
2235 (100%)
115 (100%)
2235 (100%)
Method of determining the dispersion of amplitude-frequency characteristics of alpha-rhythm of the brain in mental illness, including the identification of amplitude-frequency characteristics of alpha-rhythm on the basis of the range of its power, wherein when recording standard EEG determine the total power modal fluctuations in the range of alpha rhythm in one of the leads and calculate the indicator α 1 , as the ratio of this capacity to the total capacity of all fluctuations alpha-range and the same assignment, then determine the value of the amount of power fluctuations, located on the right and to the left of the maximum power value at approximately 0.5 Hz, including the maximum value, and calculate the indicator α 2 , as the ratio of the amount received power to the total capacity of all fluctuations alpha-band in the same lead and severity of brain damage is determined by comparison of the received values α 1 and α 2 with the normative values.