Method for orthopaedic treatment of patients with removable laminar denture
SUBSTANCE: invention refers to medicine, namely to dentistry and may be used in the orthopaedic treatment of the patients with partial and/or complete denture defects using removable laminar dentures. A method involves making the removable laminar dentures, taking the oral hygienic measures, cleaning the removable laminar dentures. Ozonised olive oil is applied on an internal surface of the prosthetic basis that is followed by applying the prosthesis on the denture defect for 10-30 minutes. The prosthesis with ozonised olive oil applied on the internal surface of the basis is attached once a day for 8-16 days.
EFFECT: method provides more effective patient's adaptation to the removable laminar dentures due to the polycomponent mechanism of ozonised olive oil in the same environment with no negative side effects.
2 ex, 2 dwg
The invention relates to medicine, namely to the dentist, and can be used in orthopedic treatment of patients with partial and/or full dentition defects removable laminar dentures.
It is known that the removable laminar dentures have a negative effect on the organs and tissue prosthetic bed. Is a violation of natural self-purification processes, resulting in deteriorating hygienic condition of the mouth. Mechanical impact dentures leads to the development and progression of inflammatory and degenerative processes in the mucosa of the prosthetic bed and periodontal remaining teeth. Created favorable conditions for the activity of the microflora, which in some cases leads to a change in its quantitative and qualitative composition. Violations of local immune protective factors conducive to the development of the above processes. There is a change in the functional parameters of the salivary flow, which is accompanied by change of the quantitative and qualitative composition of saliva. As a result, these processes have an adverse effect on the process of adaptation of patients to removable laminar dentures.
There is a method of clinical application in patients with chronic inflammatory diseases of the oral cavity ozonized is rastvorov (Cm. Fish O., a Comparative assessment of the effectiveness of non-pharmacological methods of anti-inflammatory therapy of chronic periodontitis. Graduate Bulletin of the Volga region. - 2008. - №3-4. - P. 166-169).
This method allows you to have complex effects on tissues and organs of the oral cavity, however, together with numerous advantages it has some disadvantages: the instability of the resulting ozonated solution requires its application immediately upon receipt for 30-40 minutes, which not only allows you to use this medicine at home, but requires the presence in the clinic of the ozonizer and specially trained personnel to obtain and use. Method does not have a local action of ozone directly on the desired area of the dentition or oral. In addition, in connection with short-term effect method has expressed no effect on regeneration and trophic processes in the mucous membrane of the mouth.
Closest to the claimed invention is the use in patients using removable laminar dentures, biopolymer films with immunocorrector "Imudon" for the period of adaptation, which consists in placing the elastic film with this drug on the basis removable laminar denture after conducting individual Gigi the technical events. (See Calibration AS and other evaluation of the effectiveness of drug films with immunocorrector in removable prosthetics. Institute of dentistry. - 2010. No. 1. - P.40-41).
Despite the advantages of the method immunocorrective you can affect a small number of violations that occur through the use of removable dentures: does not have direct anti-inflammatory and antibacterial action, does not affect trophic disturbances. The disadvantages of this method include the relatively rapid elimination of the drug from the mucous membranes of the oral cavity, which leads to more frequent use 2-3 times a day for 7-10 days, then 2-3 times a week for 14 days, and shallow penetration "Imudon" in the mucosa of the prosthetic bed because of hemodynamic disorders in it.
The task of the invention is to provide a method of local, more effective impact on tissue prosthetic bed ozonized solution that delivers improved clinical and laboratory parameters tissues of the oral cavity in patients using removable laminar dentures and reduction of terms of adaptation to removable laminar dentures.
This object is achieved by a combination of features, including the manufacture of removable laminar denture is in, the implementation of hygienic measures in the oral cavity, cleaning removable laminar dentures and applied to the internal surface of the prosthesis therapeutic agent, followed by the imposition of the prosthesis and new signs, namely, that as a therapeutic agent use ozonated olive oil, after applying it correctly extract tissue prosthetic bed under the influence of ozonated olive oil for 10-30 minutes, and the imposition of a prosthesis coated on the inner surface of the base ozonated olive oil is conducted once a day for 8-16 days.
The novelty of the proposed method is the use as a therapeutic agent ozonated olive oil, after applying it correctly extract tissue prosthetic bed under the influence of ozonated olive oil for 10-30 minutes, and the imposition of a prosthesis coated on the inner surface of the base ozonated olive oil is conducted once a day for 8-16 days.
Thus, the influence of ozonized olive oil on a tissue of the oral cavity within 10-30 minutes can specifically and more long-term impact on tissue prosthetic bed, preventing inflammatory and dysbiotic processes, exerting a positive influence on traffic the ski violations. This ozonated olive oil is in direct contact with the tissue prosthetic bed longer and more slowly dissolves in the oral fluid, thereby reducing the number, frequency, and time of the procedure, as well as to achieve better therapeutic results: improve the hygienic condition of the mouth, reducing the severity of inflammatory processes in the periodontium and the mucosa of the prosthetic bed, improvement of microcirculation and optimization of regenerative processes in the mucosa of the prosthetic bed, save the quantitative and qualitative composition of the microflora of the oral cavity, and consequently, reduction of terms of adaptation to removable laminar dentures.
In the prior art according to patent information research not identified a technical solution with a specified set of essential features that can be attributed to the proposed signs on the patentability criteria of the object to having novelty.
Proposed distinguishing features of the proposed facility for the specialist does not obviously follow from the prior art, which confirms the conformity of the invention, the criterion of patentability - inventive step. The proposed combination of known and new features in conjunction with the description of work supply the aqueous solution allows to recognize the object clinically applicable.
Figure 1 shows the photo removable laminar denture coated on the inner surface of its base ozonated olive oil.
Figure 2 shows a cross-section removable laminar denture placed in the mouth is coated on the inner surface of its base ozonated olive oil.
Removable laminar denture consists of artificial teeth 1 and the base 2, on the inner surface of which in contact with the tissues of the dentition and oral cavity of the patient, caused by a layer of ozonated olive oil 3. When applying removable laminar denture fits snugly to the outer surface of the top 4, or the lower jaw in the area of the missing teeth.
The proposed method of orthopedic treatment of patients removable laminar dentures as follows:
Initially, carry out the manufacture of removable laminar dentures, then spend hygienic measures in the mouth and do the cleaning removable laminar dentures and receiving ozonated olive oil. Then on the inner surface of the base 2 laminar prosthesis taken of the patient's dentition, put the pre-prepared ozonated olive oil 3. Laminar prosthesis coated on its inner surface with ozonated olive the new oil 3 place in the field of dentition defect 4. This ozonated olive oil 3, located on the base surface 2, is in direct contact with the tissue prosthetic bed 4 and acts on them. The duration of exposure to ozonated olive oil on a tissue prosthetic bed is from 10 to 30 minutes. Then the prosthesis is removed, propulsives running water and then use them carried out in the usual manner, i.e., the prosthesis is installed in the oral cavity of a patient until the next application of ozonated olive oil. This procedure of treatment once a day for 8-16 days.
A specific example of implementation of the proposed method.
Patient D., 64 years old, asked on 21 September 2011 with the aim of rational prosthesis. Thus complained of partial absence of teeth, difficulty chewing food, the diction, the aesthetic dissatisfaction. Moved and comorbidities according to the patient: history of chronic bronchitis, hypertension. The teeth were removed gradually as a result of their mobility. Removable dentures have not used. External examination: the severity of noso-lip and chin creases, slight decrease in the height of the lower part of the face.
Diagnosis: partial absence of teeth in the upper jaw of the 3rd class on Kennedy: partial no the of the teeth in the lower jaw of the 2nd class on Kennedy: the generalized periodontitis, moderate severity, chronicity: 1.7 - chronic fibrotic periodontitis.
Treatment: the manufacture of die-cast cult stud tabs on 1.7 with the subsequent production of artificial composite metal crowns. Orthopedic treatment of partial absence of teeth of the mandible was carried out in the traditional way - partial removable laminar dentures. After applying removable laminar denture was appointed the rate of application of ozonated olive oil for fourteen days. Ozonated olive oil was applied once daily in the evening after the hygienic cleaning of the teeth and the denture on the inner surface of its basis and is distributed evenly on it, then the prosthesis was placed in the defect area of the dentition for 20 minutes. Then the prosthesis was removed, rinsed under running water and then use them was carried out in the usual manner. Surveys were conducted before the prosthesis, two weeks, one month and three months. It was found that topical application of ozonated olive oil with the use of removable laminar dentures had a favorable impact on the hygienic condition of the mouth, which is determined by the hygiene index Fedorov-Volodkina: hygiene index was decreased from 2.0 to 1.5 for the second week. Register what was significant improvement in the condition of periodontal tissues, that was manifested by the decrease in the prevalence of gingivitis: the index of the prevalence of gingival inflammation (PMA) was decreased from 64 source percent to 32 percent to 3 months of observation. Decreased gingival bleeding index Mulleman-Saxena in the outcome of 1.6, three months to 0.6. The results of cytological examination testified normalization of regenerative processes in the mucosa of the prosthetic bed: was the increase of the index of differentiation of epithelial cells with 328 units 380 units to month observations with subsequent stabilization and gradual increase of the index values of keratinization with 30% in Exodus to 57% for the month of observations. Increased resistance of the mucous membrane of prosthetic bed, increased perfusion of the tissue by the second week of observation, continued quantitative and qualitative composition of the normal microflora. Thus, local application of ozonized olive oil on the surface laminar prostheses resulted in improvement of clinical and laboratory indices of tissue prosthetic bed and shortening of adaptation.
A second specific example of implementation of the proposed method.
A patient, 62 years of age, asked on 26 November 2011 with the aim of rational prosthesis. Complained of a complete lack of teeth, inability to chew, aesthetic neodol toronot. Allergic anamnesis is not burdened. Suffer from bronchial asthma, essential hypertension. The development of this disease: the teeth were removed gradually, due to their mobility and/or destruction. Removable dentures have not used. External examination: the severity of noso-lip and chin wrinkles, reducing the height of the lower section of the face, drooping corners of the mouth. In the mouth: mucous membrane is pale pink, moderately moist, moderately pliable, palpation painless, without visible pathological changes. Was determined moderately severe atrophy of the alveolar ridge of the upper jaw and severe atrophy of the alveolar part of the mandible. Diagnosis: complete absence of teeth in the upper jaw, type II by Oksman, 1 class on Supply; the complete absence of teeth in the lower jaw, type III by Oksman, 1 class on Supply. Treatment: orthopedic treatment of complete absence of teeth of the mandible was carried out in the traditional way full removable laminar dentures.
After fabrication of removable laminar dentures were prescribed course of using ozonated olive oil for 16 days. Ozonated olive oil was applied once daily in the evening after hygienic cleaning teeth and dentures on the inner surface of their bases and evenly distributed ALOS on them, further, the prosthesis was placed in the upper and lower jaw for 20 minutes. Then the prosthesis was removed, rinsed under running water and then use them was carried out in the usual manner. The survey was conducted before the prosthesis, two weeks, one and three months after.
Topical application of ozonated olive oil with the use of removable laminar dentures had a favorable impact on the hygienic state of the removable laminar dentures determined by the method Ambjornsen: 1.6 points after 2 weeks of use of the prosthesis. The results of cytological examination testified normalization of regenerative processes in the mucosa of the prosthetic bed: higher index of differentiation of epithelial cells with 334 units to 375 units to month observations followed by stabilization and a gradual increase in the index values of keratinization with 44% in Exodus to 68% for the month of observations. Was also determined for the enhancement of nonspecific resistance of the mucous membrane of prosthetic bed, which was confirmed by the increase in positive reactions adsorption of microflora from 30% in Exodus to 74% after two weeks of observations. The results of laser Doppler flowmetry microvasculature of the mucous membrane of prosthetic bed showed a positive trend is AI enhance perfusion of the tissue by the second week of observation at all control points, equal 23,44 PF. units with respect to the original value, which amounted to 15,14 PF. units Microbiological study showed preservation of the quantitative and qualitative composition of the normal microflora. The total antioxidant activity of oral fluid was increased from 0.5 mm to 1.4 mm in a month after the imposition of the prosthesis. Analysis of the questionnaires filled out by the patient, testified to the onset of full adaptation to the removable laminar denture to a 16-day wear.
Currently, the authors carried out the treatment method proposed more than 60 patients. The inventive method is technically easy to implement, allows you to have a prolonged and local action on a wide range of disorders that occur in tissues and organs of the oral cavity with the use of removable laminar dentures: a positive effect on the oral hygiene, the state of the periodontal and mucosal tissue prosthetic bed, keeps the normal microflora composition and leads to a reduction in terms of adaptation.
The application of the proposed method is possible at home.
The way orthopedic treatment of patients removable laminar dentures, including the manufacture of removable laminar dentures, the implementation of hygienic measures in the oral cavity, cleaning removable laminar dentures and drawing on the principles of the indoor surface of the prosthesis remedies followed by the imposition of the prosthesis, characterized in that as a therapeutic agent use ozonated olive oil, after applying it correctly extract tissue prosthetic bed under the influence of ozonated olive oil for 10-30 min, and the imposition of a prosthesis coated on the inner surface of the base ozonated olive oil is conducted once a day for 8-16 days.
SUBSTANCE: invention relates to field of medicine, namely to dentistry, physiotherapy. Method includes influence by defocused shock wave through applications of enterosorbent "BS-P", applied on upper and lower jaw. Influence by shock wave is realised through soft tissues of maxillofacial area. Influence is performed with pulse duration 0.4-0.7 mcs, pulse frequency 90 Hz, pressure amplitude from 6 to 9 MPa, total number of pulses 1000. Procedures are carried out every second day. Course includes 7-10 sessions.
EFFECT: method enhances reparative processes due to correction of disorders of microcirculation and metabolism stimulation.
SUBSTANCE: group of inventions refers to medicine, and aims at treating patient's oral diseases. Cultured tissue constructs of fibroblast dermal cells are implanted onto the oral tissue. The cultured tissue constructs comprise the cultured cells and endogenous-produced extracellular matrix components without the exogenous matrix or network sustaining or scaffold links.
EFFECT: group of inventions enables providing more simple and less painful treatment of the oral diseases requiring the implanted tissue constructs to be used.
33 cl, 36 ex, 21 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine and relates to disturbed salivation. A composition containing sialic acid for treating or preventing the diseases related to disturbed salivation contains a protein fraction containing 7 to 25 wt % of N-acetylneuraminic acid and threonine in the amount of 8 to 22% of total amino acids, wherein N-acetylneuraminic acid is bound to a threonine-enriched peptide-protein network.
EFFECT: invention enables increasing salivation, especially observed in elderly persons and accompanying such diseases as dysphagia, xerostomia and a combination thereof.
23 cl, 2 dwg
SUBSTANCE: group of inventions relates to dental seals and methods of their application. Composition of dental seal in form of varnish includes arginine in free form or in form of salt, rosin, white beeswax, mastic, shellac and source of fluoride ions, which is present in composition in concentration, at least 12 wt %, and is selected from group, including tin fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, aluminium fluoride, sodium hydrofluoride, sodium fluoride, calcium fluoride, magnesium fluoride and potassium fluoride. Also claimed is method of treating sensitive teeth, which includes application of said seal composition in form of varnish on tooth of person, requiring treatment, and application of claimed method for improvement of oral cavity health. Application of arginine in said composition of dental seal makes it possible to use fluoride-ions in a larger quantity than is usually used in dental varnishes, without side effects, associated with excess of fluoride-ions.
EFFECT: composition of seal makes it possible to ensure regulated continuous supply of medication.
12 cl, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, particularly to pharmacy and dentistry, and concerns creating new compositions of menthol derivatives. For this purpose, 2-isopropyl-5-methylcyclohexyl-2-hydroxyphenylcarbamate is suggested to be used as an antioxidant, anti-inflammatory and antimicrobial agent for local treatment of the oral cavity, e.g. periodontal diseases. That provides the basis to present the compositions containing an effective amount of 2-isopropyl-5-methylcyclohexyl-2-hydroxyphenylcarbamate, and at least one excipient.
EFFECT: inventions provide treating the oral cavity ensured by an integrated effect on general mechanisms of pathogenesis.
7 cl, 7 tbl, 2 ex, 5 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutics and represents a method of preventing and treating oral inflammation following a dental surgery, comprising in applying a drug preparation on an incisional wound daily in a patient underwent the implantation procedure and characterised by the fact that the drug preparation used represents a preparation of the strain lactobacillus plantarum 8P-AZ and/or B.bifidum in a dose of at least 10 million live lactic acid bacilli and/or bifidus bacteria.
EFFECT: invention provides simplifying the method of preventing and treating the oral inflammation by making it unnecessary to prepare the drug used if antibiotics are avoided.
2 cl, 9 ex, 9 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to chemical-pharmaceutical and cosmetic industry and represents artificial saliva containing arginine either in the free form, or in the form of a salt together with one or more of: a) a calcium ion source, b) a phosphate ion source, c) a potassium ion source, d) a magnesium ion source, e) a fluoride ion source; f) a flavour stimulating saliva flow; and/or g) a polyol humidifier.
EFFECT: invention provides creating the agent containing arginine or a salt thereof for treating, improving, slowing or preventing dry mouth.
8 cl, 3 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutics and represents an agent for local treatment of periodontal diseases, on the basis of organosilicone gycerohydrogel Si(C3H7O3)4·6C3H8O3·24H2O, containing therapeutic supplements, differing by the fact that the therapeutic supplements are presented by ketoprofen and methyluracil in the following proportions, wt %: ketoprofen - 0.5 - 1.0; methyluracil - 1.0 - 1.5; organosilicone gycerohydrogel Si(C3H7O3)4·6C3H8O3·24H2O - up to 100.
EFFECT: invention provides creating the effective agent applicable in the integrated therapy for treating the inflammatory periodontal diseases.
SUBSTANCE: invention relates to medicine, namely to dentistry. Method includes processing perforated root canal and perforation zone with laser irradiation and covering perforation with sealing material. Introduction of light-guide into perforated root canal is carried out. In processing by laser irradiation translational increase of its power parameters is used. During the first session processing is carried out with power 0.5 W, during the second session - 0.75 W, during the third - 1.5 W. Additionally ozone therapy with saturated physiological solution is performed. Time of saturation with ozone is 5 minutes. Concentration of ozone dissolved in physiological solution is 8.8-9.6 mg/l.
EFFECT: method is painless, does not require carrying out local anesthesia, excludes allergic reactions, ensures optimal bactericidal and bacteriostatic effect, which makes it possible to efficiently stop inflammation and reconstruction of bone tissue, reduces number of complications.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, namely to dentistry, and concerns preparations for preventing and treating the diseases of periodontal membrane and oral mucosa. That is ensured by using a pharmaceutical composition in the form of a gel which contains metronidazole benzoate, chlorhexidine gluconate as an active substance and additionally the ingredients specified in a group of alpha-, beta-, gamma-, recombinant interferon.
EFFECT: invention provides reducing the length of treatment in the patients with inflammatory periodontal diseases due to the wide spectrum of action of the composition, prolonged fixation on gums, which accelerates the regeneration of the oral mucosa.
2 cl, 5 ex
SUBSTANCE: invention refers to medicine, namely gerontology, and may be used for preventing the premature human ageing. That is ensured by adding the food ration with min. 50 g of the functional foodstuff 'Samarskiy Zdorovyak' per one intake - with breakfast or lunch or dinner with underlying diet therapy.
EFFECT: method enables providing more effective prevention of the premature ageing due to enhancing the body adaptability, reducing hyperlipidemia, stimulating fat splitting, reducing abdominal obesity and normalising blood pressure.
SUBSTANCE: invention refers to method for producing a chromogenic shelf fungus complex, wherein milled shelf fungus is wetted in ratio (0.5-1.5) - (3.5-4.5), frozen at temperature minus 16±3°C for 1-4 hours, settled for 1-2 hours at temperature 65-75°C, filtered; the filtrate is acidified in 25% hydrochloric acid to pH 1.0-2.0, mixed, settled for 12-15 hours and filtered.
EFFECT: declared invention provides higher yield of the chromogenic shelf fungus complex and higher antioxidant activity.
1 tbl, 20 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to agent possessing antiviral action, and may be used for treating herpes infections, including lip sore. The given agent contains the ingredients, wt %: a solution readily permeable through biological membranes of soapy amphiphilic complex of high-polymer RNA of Saccharomyces cerevisiae and oleic acid (as an interferon inducer) - 49.96; Vaseline oil - 20; Tween-80 - 17; Emulsifier T-2 - 13; Chlorhexidine Bigluconate - 0.04.
EFFECT: preparation shows high antiherpetic activity, good tolerability and ability to reduce a recurrence rate considerably.
SUBSTANCE: invention refers to medicine, namely to neurology, and may be used for treating spasticity accompanied by improved consciousness in the patients in the vegetative state. That is ensured by administering Xeomin (botulinumtoxinA free from complexing proteins) into the spastic muscles of all the extremities and related body segments regardless of the contractions in total dose of 400-1300 units. The dose shall not exceed 24 unit/kg of body weight in 1-3 stages. The stages follow at least every 3 days. Every 1-day stage involves administering 5-50 units in each accessible muscle or muscle group with the maximum tone in max. total dose 500 units dissolved in 12.5 unit/ml. The injections are distributed uniformly along the area without electromyography. The following courses are similar if observing spasticity and/or if clinically reasonable. The length of one course is up to 3 weeks.
EFFECT: method enables improving the therapeutic effect in the vegetative states.
3 ex, 3 tbl
SUBSTANCE: invention relates to field of cosmetology and represents preparation for removing nail polish, which contains organic solvent, cosolvents and target additives characterised by the fact that propylene glycol is used as organic solvent, mixture of ethyl alcohol, ethyl acetate, propylene carbonate, dimethyl glutarate, isopropyl alcohol are used as cosolvents, and mixture of glycerol, gelatin, jojoba oil and denatonium benzoate is used as target additive, with components in preparation being in specified wt % ratio.
EFFECT: invention ensures creation of preparation for removing nail polish without unpleasant smell, with wide spectrum of efficient effect on different types of manicure polishes, as well as characterised by restoring impact on nails, and impossibility of accidental intake as food.
SUBSTANCE: invention refers to medicine, namely to - arthrology, physiotherapy, balneology. The method involves physical methods of therapy, therapeutic exercises, massage, acupuncture and phytotherapy. The patients are trained to give a self-massage of the knee joints additionally during the resort therapy and after the termination of the rehabilitation. From the 1st to 10th day of the therapeutic course patient's knee joint is exposed to polychromatic polarised light at 20 cm for 6 minutes. The patients take 10 iodine-bromine baths at temperature 37°C for 10 minutes. From the 1st to 5th therapeutic days, the patients do combined therapeutic exercises; their lower extremities are massaged manually for 10 minutes. From the 6th to 15th days, the knee joints are exposed to sinusoid modulated currents (SMC) at modulation frequency 100 Hz, at a depth of 50 - 70%, current intensity to moderate vibration for 7 minutes. From the 6th to 10th days, the braking acupuncture follows by giving a 1-2-minute massage of the points 10RP, 9RP, 36E, 34E by introducing a needle for 30 seconds and by giving a point massage of cheng-fu, cuan, yang-lin-cuan, zu-sang-li, wei-yang, cheng-shan, chung-feng, hun-lun, nei-ting. The patients take a herbal infusion. From the 11th to 15th days, the knee joints are exposed to decimetric waves (DMW). That is followed by a hydro-massage of the lower extremities and lumbar region for 15 minutes up to 3 atm. Thereafter, the 10-minute post-isometric relaxation of the quadriceps muscle of thigh is applied. The patients do the complex of weight reduction exercises and take the herbal infusion. From the 16th to 20th day, the mud applications on the knee joints are prescribed at temperature 42°C for 30 minutes. If suffering gonarthrosis, the patients do the complex of therapeutic exercises. That is followed by the paravertebral vacuum therapy of the vertebral column. The 10-minute knee joint traction is applied. The patients take 20 g of the herbal infusion.
EFFECT: method recovers the joint mobility, improves the exercise tolerance of the lower extremities.
1 tbl, 2 ex
FIELD: food industry.
SUBSTANCE: invention relates to biotechnology and fodder production, in particular, to a method for production of a fodder additive for prevention of anima and bird mycotoxicosis. The method envisages mechanochamical treatment of the raw stock components with further granulation of the produced mixture. The components are represented by a mixture containing a mineral sorbent, hydrolised lignin and fodder yeast cell walls. The mechanochemical treatment consists in milling individual components in rotary vortex mills with an embedded particle classifier of in the components mixing and treatment in the presence of at least one compound enzyme preparation affecting hydrolised lignin residual polysaccharides and yeast cell walls polysaccharides.
EFFECT: method allows to produce a compound additive having a wide range of effects with improved efficiency of fodder mycotoxins binding, stimulating the immune system and preventing malfunctions in the animal and bird digestive tract; at the same time, combined usage of hydrolised lignin, fodder yeast and a mineral sorbent as a preventive agent with animals allows to minimise the sorbent application side effect, recover the digestive tract homeostasis and normalise metabolic indices.
15 cl, 12 tbl, 3 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, namely pharmacology and may be used for cerebral protection in treating cerebral affections. That is ensured by using Zongorine as a cerebroprotective agent.
EFFECT: agent provides the cerebroprotective action and prevents the death in animals suffering experimental post-hypoxic encephalopathy due to the activation of cerebral neutral stem cells.
2 ex, 3 tbl
SUBSTANCE: invention refers to cosmetology and represents a cosmetic skin care product in the form of a water-in-oil emulsion, containing: (A) a volatile hydrocarbon oil 3 to 25 wt %, (B) a non-volatile silicon oil 2 to 15 wt %, (C) polyethylene glycol mono- or diisostearate 0.1 to 0.8 wt % containing 4 to 12 groups of oxyethylene, (D) polyoxyethylene and polydimethyl siloxyehtyl dimethicone copolymer 1 to 5 wt %, an d (E) organically modified clay mineral 1.5 to 3 wt %; the ingredients normally introduced into the skin care products - the rest.
EFFECT: provided excellent stability and no oily, slick and creaking sensations.
6 cl, 3 ex, 4 tbl
SUBSTANCE: invention refers to cosmetology and represents a cosmetic product for lips containing the ingredients (a)-(d): (a) hydrogenised polyisobutene 10 to 30 wt %; (b) one or more methylphenylsicicones 30 to 70 wt % to be separated when mixed with (a) at 25°C specified in trimethyl pentaphenyltrisiloxane, diphenyl siloxyphenyl trimethicone, diphenyl dimethicone and phenyl trimethicone, and containing trimethyl pentaphenyl trisiloxane; (c) one or more lipophilic substrates 0.5 to 8 wt % not separated when mixed both with the ingredient (a), and with the ingredient (b) at 90°C specified in sorbitane sesquiisostearate, propylene glycol monostearate, cetyl-PEG/PPG-10/1 dimethicone and diglycerol diisostearate; and (d) wax 5 to 12 wt %.
EFFECT: provided excellent effect of second adhesion stability immediately after application, long-lasting gloss and stability.
10 cl, 22 ex, 1 dwg, 13 tbl
SUBSTANCE: invention refers to pharmaceutical industry and represents a method for introducing gold nanoparticles into the body by the local skin application, differing by applying the preparation of the following composition: 96% dimethyl sulphoxide 0.1 ml per a gel base 1 ml with gold nanoparticles d=140 nm, or the preparation of the following composition: 20% thiophane sulphoxide 0.1 ml per a gel base 1 ml with gold nanoparticles d=40 nm; the skin areas coated with gold nanoparticles in complex with organic sulphur compounds shall be exposed to ultrasound at frequency 1 MHz, power 2 Wt and length 2 minutes.
EFFECT: invention provides higher transdermal permeability of gold nanoparticles and no nanoparticle accumulation in the internal organs.