Method for producing chromogenic shelf fungus complex

FIELD: medicine.

SUBSTANCE: invention refers to method for producing a chromogenic shelf fungus complex, wherein milled shelf fungus is wetted in ratio (0.5-1.5) - (3.5-4.5), frozen at temperature minus 16±3°C for 1-4 hours, settled for 1-2 hours at temperature 65-75°C, filtered; the filtrate is acidified in 25% hydrochloric acid to pH 1.0-2.0, mixed, settled for 12-15 hours and filtered.

EFFECT: declared invention provides higher yield of the chromogenic shelf fungus complex and higher antioxidant activity.

1 tbl, 20 ex

 

The invention relates to pharmaceutical, food and cosmetic industry and is concerned with the obtaining of a chromogenic complex fungus.

Drugs and Supplements from a fungus effectively used for the treatment and prevention of gastrointestinal diseases, cancer of various etiologies. The main active ingredient extracts of chaga is a chromogenic complex with antioxidant activity. Current is the most complete extraction of raw materials chromogenic complex. The difficulty of removing it lies in the complexity of the structure and the characteristics of the formation, as in the mushroom fungus, and during the extraction process. The resulting diffusion juices fungus is a complex colloidal system of the dispersed phase, which is a chromogenic complex. The stability of this system depends on the conditions of extraction of the extractive substances. Significant impact on the completeness of extraction provides a combination of factors extraction (temperature and hydrodynamic conditions, duration of extraction, the degree of grinding of raw materials and so on). The intensification of the extraction process leads to an increase in output chromogenic complex, as there are structural and spatial changes, which in turn has an effect on its antioxidant activity.

Known for the way the floor is placed besieged polyphenolic complex of the fungus, including the production of diffusion juice fungus using as extractant aqueous solution of dimethyl sulfoxide to a concentration of 1÷1·10-6%, the precipitation of the polyphenolic complex by adding a 20%aqueous solution of hydrochloric acid to a pH of 2.0-2.2 (patent RU №2392952, AK 36/06, OR 39/06, 27.06.2010).

Known methods for producing precipitated drug fungus, which first obtained the diffusion juice fungus using as extractant aqueous solution generatinga polymer with a concentration of 1·10-3-1·10-22% (patent RU №2392953, AK 36/06, A61P 39/06, publ. 27.06.2010) or an aqueous solution of hyperbranched polymer Boltorn 40 with a concentration of 1·10-7-1·10-20% (patent RU №2425686, AK 36/06, B01D 11/02, publ. 10.08.2011), which then precipitated polyphenolic complex with 20%hydrochloric acid to a pH of 2.0-2.2, filtered.

The disadvantages of the known methods are use in the extraction of additional (except water) compounds that can be embedded in the complex. The effect of these compounds in the composition of a chromogenic complex on its therapeutic activity is poorly understood.

A method of obtaining a chromogenic complex of the fungus, including the production of aqueous extract of the fungus, filtering, addition of calcium chloride, filtering the precipitated sludge (patent R No. 2442596, AC 36/06, B01D 11/02, publ. 20.02.2012).

The disadvantage of this method is the low output chromogenic complex.

The closest technical solution adopted as a prototype, is a method of obtaining a chromogenic complex of the fungus, in which powdered chaga pour water in the ratio(0,5÷1,5)-(3,5÷4,5), insist 1-2 hours at 65-75°C., filtered, the filtrate acidified with 25%hydrochloric acid to a pH of 1.0 to 2.0, mix, defend 12-15 h, filtered (patent RU №2450817, AK 36/06, B01D 11/02, publ. 20.05.2012).

The disadvantages of this method are the low yield and antioxidant activity of a chromogenic complex.

The task of the invention is to increase the output of a chromogenic complex and increase its antioxidant activity.

The problem is solved by a method of obtaining a chromogenic complex of the fungus, in which powdered chaga pour water in a mass ratio of(0,5÷1,5)-(3,5÷4,5), then frozen at a temperature of minus 16±3°C for 1-4 hours, insist 1-2 hours at 65-75°C., filtered, the filtrate acidified with 25%hydrochloric acid to a pH of 1.0 to 2.0, mix, defend 12-15 hours, filtered.

The technical result of the invention is to increase the output of a chromogenic complex and increase its antioxidant activity.

Increase the yield of extractivist and exit chromogenic complex upon receipt of a chromogenic complex of the fungus in the present invention in comparison with the prototype achieved by the introduction of frozen chopped fungus with water. The essence of freezing is that the moisture in the raw material (moisture of raw materials 14%) under the action of low temperatures, turning into a large ice crystals, mainly in the intercellular space. Forming ice crystals destroy the cell wall of the fungus the fungus, which extractive substances, including chromogenic complex, become more available for extraction. Freeze chopped fungus together with water (extractant) enhances this effect. Rupture of the cell walls is not only due to internal moisture of the fungus, but also due to the fact that the extractant itself crystallizes. This deformation of cell membranes increases, leading to an increase in the number of micropores and microcracks with a large size. Due to the sharp temperature drop (from negative to 65-75°C) rupture strain of cell membranes, and increased the number of micropores and microcracks facilitates the extraction of chromogenic complex from the mycelium of the fungus that intensifies the process of its extraction. Ultimately increases the output of a chromogenic complex.

The use of pre-freezing changes the structural organization of recoverable chromogenic complex, as confirmed microscopy (microscope 100 MS (LCD PC) Operation manual Micros, Austria). XP is moeny complex, obtained according to the invention, has a more ordered structure than those obtained by the method prototype. The dimensions of a chromogenic complex increases. Large external surface of the complex has a greater number of functional groups responsible for binding of free radicals, and, as a consequence, this leads to an increase in antioxidant activity chromogenic complex.

Freezing is carried out at a temperature of minus 16±3°C for 1-4 hours. Use when freezing temperatures below minus 19°C, as it is known from literature data, does not lead to deformation of the cell walls, on the contrary contribute to the preservation of the native structure of materials [Golovkin N.A. Refrigeration technology of food products. - M: Light and food industry, 2004]. At temperatures above freezing minus 13°C, ice crystals are formed more slowly, which does not have a significant effect on the deformation of the cell walls. Thus, under these temperature conditions, the yield of the desired product decreases.

Freezing less than 1 hour does not allow water to go fully into the crystalline state, therefore, the deformation of the cell walls is minimal, while the yield of the target product is also reduced. Long-term freezing (over 4 hours) is impractical because the yield of the target product does not increase the perform and even decreases slightly.

Specific examples of the implementation of the method.

To confirm the effect used two kinds of raw materials: raw materials 1 - chaga Inonotus obliquus, JSC "Krasnogorskleksredstva", series 131211 suitable to 01.12.2014; raw materials 2 - chaga Inonotus obliquus, CJSC "Company "Health", series 061210 suitable to 01.13.

Example 1. Powdered chaga (raw material 1) pour water in the ratio 1:4, frozen 0.5 h together with the extractant in the refrigerating chamber at a temperature of minus 16°C, then heated to 70°C and insist 1.5 h, filtered, the filtrate acidified with 25% hydrochloric acid to a pH of 1.0 to 2.0, mix, defend 12-15 hours, filtered.

Example 2-10. Similar to example 1. Performance conditions shown in the table.

Example 11-20. Similar to examples 1-10, but use raw materials 2. Performance conditions shown in the table.

It is known that the output of a chromogenic complex and its antioxidant activity can vary greatly depending on the feedstock used (Sysoeva M.A., Kuznetsov O.Y, Gamayurova V.S., Sukhanov P.P., Ziyatdinova G.K., Budnikov G.K. Study Zola introductory extracts of the fungus. III. The influence of raw material composition on the yield of extractive substances of aqueous extracts of chaga // Chemistry of plant raw materials, 2004 - No. 4. - P.29-34; Kuznetsova O.Y Physico-chemical characterization and biological activity of aqueous extracts and polifenoloksikarbonovogo complex of the fungus. Diss. on SOEs. academic step. K.H. is. - Kazan, 2004. - S). Therefore, for correct comparison of the results from the prototype method were obtained chromogenic complexes on raw chaga 1 and 2.

The output of a chromogenic complex was determined according to the State Pharmacopoeia of the USSR: XI, Issue 1 and 2. - M.: Medicine; 1990.

Antioxidant activity (AOA) of a chromogenic complex was determined by the method of determining the integral antioxidant capacity of biological fluids (patent RU №2253114, IPC G01N 33/48, 2005).

The experimental results processed using Statistics 6" and are listed in the table at confidence probability P=0.95, and n=7 (n is the sample size or the number of experiments).

Analysis of the tabular data shows that pre-freeze raw chaga water allows to increase the output of a chromogenic complex 92% (example 2), 121% (example 11); however, its antioxidant activity is increased by 45% (example 2), 41% (example 11) in comparison with the prototype, regardless of the quality of the raw materials used.

75 68
Table 1
The influence of freezing conditions on the output of a chromogenic complex of the fungus and its antioxidant activity
# exampleMode Zamora is the air traffic management Mode extractionThe output of HC*, %The AOA HC, kcal/100 g
The ratio of raw material: extractantTemperature, °CTime, hTemperature, °CTime, h
Raw material 1. Chaga Inonotus obliquus. JSC "Krasnogorskleksredstva". Series 131211. Good to 01.12.2014
The placeholder1:4-0701,518,123,0
0,5:4,5-07227,416,9
11:4-160,5681,521,322,0
21:4 -161701,534,832,0
31:4-162701,532,4of 31.4
41:4-16365231,931,0
51:4-164681,526,828,0
60,5:4,5-131,575114,520,0
70,5:4,5-191,5212,919,6
81:4-11272119,123,0
91:4-21270219,824,1
Raw material 2. Chaga Inonotus obliquus. CJSC "Company "Health", Series 061210. Good till 01.13
The placeholder1:4-0701,515,949,0
0,5:4,5-07226,736,6
101:4-160,51,520,646,0
111:4-161701,535,168,9
121:4-162701,5to 33.864,6
131:4-16365232,664,0
141:4-164681,5to 25.361,1
150,5:4,5-131,575112, 38,9
160,5:4,5-191,575211,2of 37.8
171:4-11272116,548,0
181:4-212702the 17.346,4
* - the percentage of the raw materials taken for extraction. AAO - antioxidant activity. HC - chromogenic complex

The use of a shorter or longer time interval freezing is less effective. During a short time interval (examples 1, 10) output chromogenic complex increases slightly and antioxidant activity of such complexes is lower than in the prototype. For longer freezing (examples 5, 14) output chromogenic complex at Illichivets and its antioxidant activity increases insignificantly.

Temperature and hydrodynamic conditions below and above the interval for the proposed method (examples 8, 9, 17, 18) also do not contribute to the increase chromogenic complex and its antioxidant activity.

Thus, the use of the proposed invention but compared to the prototype allows you to:

- to increase the output of a chromogenic complex in average 2 times;

- to increase the antioxidant activity of a chromogenic complex on average 1.5 times.

The proposed method can be implemented in industries for production of a chromogenic complex fungus. In the future it is recommended that it be used for medicines, cosmetics, food and dietary supplements.

A method of obtaining a chromogenic complex of the fungus, in which powdered chaga pour water in a mass ratio of(0,5÷1,5)-(3,5÷4,5), insist 1-2 hours at 65-75°C., filtered, the filtrate acidified with 25%hydrochloric acid to a pH of 1.0 to 2.0, mix, defend 12-15 hours, filtered, characterized in that chaga water pre-frozen at minus 16±3°C for 1-4 hours



 

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