Method for producing chromogenic shelf fungus complex
SUBSTANCE: invention refers to method for producing a chromogenic shelf fungus complex, wherein milled shelf fungus is wetted in ratio (0.5-1.5) - (3.5-4.5), frozen at temperature minus 16±3°C for 1-4 hours, settled for 1-2 hours at temperature 65-75°C, filtered; the filtrate is acidified in 25% hydrochloric acid to pH 1.0-2.0, mixed, settled for 12-15 hours and filtered.
EFFECT: declared invention provides higher yield of the chromogenic shelf fungus complex and higher antioxidant activity.
1 tbl, 20 ex
The invention relates to pharmaceutical, food and cosmetic industry and is concerned with the obtaining of a chromogenic complex fungus.
Drugs and Supplements from a fungus effectively used for the treatment and prevention of gastrointestinal diseases, cancer of various etiologies. The main active ingredient extracts of chaga is a chromogenic complex with antioxidant activity. Current is the most complete extraction of raw materials chromogenic complex. The difficulty of removing it lies in the complexity of the structure and the characteristics of the formation, as in the mushroom fungus, and during the extraction process. The resulting diffusion juices fungus is a complex colloidal system of the dispersed phase, which is a chromogenic complex. The stability of this system depends on the conditions of extraction of the extractive substances. Significant impact on the completeness of extraction provides a combination of factors extraction (temperature and hydrodynamic conditions, duration of extraction, the degree of grinding of raw materials and so on). The intensification of the extraction process leads to an increase in output chromogenic complex, as there are structural and spatial changes, which in turn has an effect on its antioxidant activity.
Known for the way the floor is placed besieged polyphenolic complex of the fungus, including the production of diffusion juice fungus using as extractant aqueous solution of dimethyl sulfoxide to a concentration of 1÷1·10-6%, the precipitation of the polyphenolic complex by adding a 20%aqueous solution of hydrochloric acid to a pH of 2.0-2.2 (patent RU №2392952, AK 36/06, OR 39/06, 27.06.2010).
Known methods for producing precipitated drug fungus, which first obtained the diffusion juice fungus using as extractant aqueous solution generatinga polymer with a concentration of 1·10-3-1·10-22% (patent RU №2392953, AK 36/06, A61P 39/06, publ. 27.06.2010) or an aqueous solution of hyperbranched polymer Boltorn 40 with a concentration of 1·10-7-1·10-20% (patent RU №2425686, AK 36/06, B01D 11/02, publ. 10.08.2011), which then precipitated polyphenolic complex with 20%hydrochloric acid to a pH of 2.0-2.2, filtered.
The disadvantages of the known methods are use in the extraction of additional (except water) compounds that can be embedded in the complex. The effect of these compounds in the composition of a chromogenic complex on its therapeutic activity is poorly understood.
A method of obtaining a chromogenic complex of the fungus, including the production of aqueous extract of the fungus, filtering, addition of calcium chloride, filtering the precipitated sludge (patent R No. 2442596, AC 36/06, B01D 11/02, publ. 20.02.2012).
The disadvantage of this method is the low output chromogenic complex.
The closest technical solution adopted as a prototype, is a method of obtaining a chromogenic complex of the fungus, in which powdered chaga pour water in the ratio(0,5÷1,5)-(3,5÷4,5), insist 1-2 hours at 65-75°C., filtered, the filtrate acidified with 25%hydrochloric acid to a pH of 1.0 to 2.0, mix, defend 12-15 h, filtered (patent RU №2450817, AK 36/06, B01D 11/02, publ. 20.05.2012).
The disadvantages of this method are the low yield and antioxidant activity of a chromogenic complex.
The task of the invention is to increase the output of a chromogenic complex and increase its antioxidant activity.
The problem is solved by a method of obtaining a chromogenic complex of the fungus, in which powdered chaga pour water in a mass ratio of(0,5÷1,5)-(3,5÷4,5), then frozen at a temperature of minus 16±3°C for 1-4 hours, insist 1-2 hours at 65-75°C., filtered, the filtrate acidified with 25%hydrochloric acid to a pH of 1.0 to 2.0, mix, defend 12-15 hours, filtered.
The technical result of the invention is to increase the output of a chromogenic complex and increase its antioxidant activity.
Increase the yield of extractivist and exit chromogenic complex upon receipt of a chromogenic complex of the fungus in the present invention in comparison with the prototype achieved by the introduction of frozen chopped fungus with water. The essence of freezing is that the moisture in the raw material (moisture of raw materials 14%) under the action of low temperatures, turning into a large ice crystals, mainly in the intercellular space. Forming ice crystals destroy the cell wall of the fungus the fungus, which extractive substances, including chromogenic complex, become more available for extraction. Freeze chopped fungus together with water (extractant) enhances this effect. Rupture of the cell walls is not only due to internal moisture of the fungus, but also due to the fact that the extractant itself crystallizes. This deformation of cell membranes increases, leading to an increase in the number of micropores and microcracks with a large size. Due to the sharp temperature drop (from negative to 65-75°C) rupture strain of cell membranes, and increased the number of micropores and microcracks facilitates the extraction of chromogenic complex from the mycelium of the fungus that intensifies the process of its extraction. Ultimately increases the output of a chromogenic complex.
The use of pre-freezing changes the structural organization of recoverable chromogenic complex, as confirmed microscopy (microscope 100 MS (LCD PC) Operation manual Micros, Austria). XP is moeny complex, obtained according to the invention, has a more ordered structure than those obtained by the method prototype. The dimensions of a chromogenic complex increases. Large external surface of the complex has a greater number of functional groups responsible for binding of free radicals, and, as a consequence, this leads to an increase in antioxidant activity chromogenic complex.
Freezing is carried out at a temperature of minus 16±3°C for 1-4 hours. Use when freezing temperatures below minus 19°C, as it is known from literature data, does not lead to deformation of the cell walls, on the contrary contribute to the preservation of the native structure of materials [Golovkin N.A. Refrigeration technology of food products. - M: Light and food industry, 2004]. At temperatures above freezing minus 13°C, ice crystals are formed more slowly, which does not have a significant effect on the deformation of the cell walls. Thus, under these temperature conditions, the yield of the desired product decreases.
Freezing less than 1 hour does not allow water to go fully into the crystalline state, therefore, the deformation of the cell walls is minimal, while the yield of the target product is also reduced. Long-term freezing (over 4 hours) is impractical because the yield of the target product does not increase the perform and even decreases slightly.
Specific examples of the implementation of the method.
To confirm the effect used two kinds of raw materials: raw materials 1 - chaga Inonotus obliquus, JSC "Krasnogorskleksredstva", series 131211 suitable to 01.12.2014; raw materials 2 - chaga Inonotus obliquus, CJSC "Company "Health", series 061210 suitable to 01.13.
Example 1. Powdered chaga (raw material 1) pour water in the ratio 1:4, frozen 0.5 h together with the extractant in the refrigerating chamber at a temperature of minus 16°C, then heated to 70°C and insist 1.5 h, filtered, the filtrate acidified with 25% hydrochloric acid to a pH of 1.0 to 2.0, mix, defend 12-15 hours, filtered.
Example 2-10. Similar to example 1. Performance conditions shown in the table.
Example 11-20. Similar to examples 1-10, but use raw materials 2. Performance conditions shown in the table.
It is known that the output of a chromogenic complex and its antioxidant activity can vary greatly depending on the feedstock used (Sysoeva M.A., Kuznetsov O.Y, Gamayurova V.S., Sukhanov P.P., Ziyatdinova G.K., Budnikov G.K. Study Zola introductory extracts of the fungus. III. The influence of raw material composition on the yield of extractive substances of aqueous extracts of chaga // Chemistry of plant raw materials, 2004 - No. 4. - P.29-34; Kuznetsova O.Y Physico-chemical characterization and biological activity of aqueous extracts and polifenoloksikarbonovogo complex of the fungus. Diss. on SOEs. academic step. K.H. is. - Kazan, 2004. - S). Therefore, for correct comparison of the results from the prototype method were obtained chromogenic complexes on raw chaga 1 and 2.
The output of a chromogenic complex was determined according to the State Pharmacopoeia of the USSR: XI, Issue 1 and 2. - M.: Medicine; 1990.
Antioxidant activity (AOA) of a chromogenic complex was determined by the method of determining the integral antioxidant capacity of biological fluids (patent RU №2253114, IPC G01N 33/48, 2005).
The experimental results processed using Statistics 6" and are listed in the table at confidence probability P=0.95, and n=7 (n is the sample size or the number of experiments).
Analysis of the tabular data shows that pre-freeze raw chaga water allows to increase the output of a chromogenic complex 92% (example 2), 121% (example 11); however, its antioxidant activity is increased by 45% (example 2), 41% (example 11) in comparison with the prototype, regardless of the quality of the raw materials used.
|The influence of freezing conditions on the output of a chromogenic complex of the fungus and its antioxidant activity|
|# example||Mode Zamora is the air traffic management||Mode extraction||The output of HC*, %||The AOA HC, kcal/100 g|
|The ratio of raw material: extractant||Temperature, °C||Time, h||Temperature, °C||Time, h|
|Raw material 1. Chaga Inonotus obliquus. JSC "Krasnogorskleksredstva". Series 131211. Good to 01.12.2014|
|Raw material 2. Chaga Inonotus obliquus. CJSC "Company "Health", Series 061210. Good till 01.13|
|* - the percentage of the raw materials taken for extraction. AAO - antioxidant activity. HC - chromogenic complex|
The use of a shorter or longer time interval freezing is less effective. During a short time interval (examples 1, 10) output chromogenic complex increases slightly and antioxidant activity of such complexes is lower than in the prototype. For longer freezing (examples 5, 14) output chromogenic complex at Illichivets and its antioxidant activity increases insignificantly.
Temperature and hydrodynamic conditions below and above the interval for the proposed method (examples 8, 9, 17, 18) also do not contribute to the increase chromogenic complex and its antioxidant activity.
Thus, the use of the proposed invention but compared to the prototype allows you to:
- to increase the output of a chromogenic complex in average 2 times;
- to increase the antioxidant activity of a chromogenic complex on average 1.5 times.
The proposed method can be implemented in industries for production of a chromogenic complex fungus. In the future it is recommended that it be used for medicines, cosmetics, food and dietary supplements.
A method of obtaining a chromogenic complex of the fungus, in which powdered chaga pour water in a mass ratio of(0,5÷1,5)-(3,5÷4,5), insist 1-2 hours at 65-75°C., filtered, the filtrate acidified with 25%hydrochloric acid to a pH of 1.0 to 2.0, mix, defend 12-15 hours, filtered, characterized in that chaga water pre-frozen at minus 16±3°C for 1-4 hours
SUBSTANCE: invention refers to medicine, namely to pharmaceutical industry, concerns preparing a chlorophyll concentrate of sugar laminaria. A method for preparing the chlorophyll concentrate of grinded sugar laminaria by three extractions in ethanol in a shadowed place; further, cake extract is separated; the extractants are combined; the extragent is distilled; the residue is added with water, filtered through a paper filter; the filtered residue is washed in two-three portions of water, dissolved in 96% ethanol; total chlorophylls are dissolved in sterile olive oil to produce 25% total chlorophyll concentration, residual 96% ethanol is distilled under vacuum; the method is conducted in the specific environment.
EFFECT: chlorophyll concentration is prepared by the above method is characterised by high purity and stability of the active substances.
7 dwg, 1 tbl
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, namely a method for preparing an agent possessing immunomodulatory activity. The method for preparing an agent possessing immunomodulatory activity characterized by the fact that herbal composition containing common motherwort herb, knotgrass herb, pot marigold blossom, licorice rhizome and root, Alexandrian laurel rhizome and root, rosehip, schizandra fruit, linseeds, sequentially twice extracted in 60-70% ethanol, twice in 40-50% ethanol, and once in purified water under specific conditions; then the aqueous-alcoholic extracts are concentrated in vacuum; the aqueous still residues are combined with the aqueous extract, then filtered, boiled out, purified by separation, boiled out additionally, dried in a vacuum dryer and further milled.
EFFECT: method enables preparing the agent possessing manifested immunomodulatory activity with the high content of active substances.
13 tbl, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, namely a method for preparing an agent possessing tonic activity. The method for preparing the agent of true ginseng roots, possessing tonic activity by three extractions of the ground raw material in 40-80% ethanol with using three extraction vessels in the specific environment; at first the extraction process takes place at room temperature for 12 hours, while the third extraction is conducted at temperature 90°C for 30 minutes in each extraction vessel.
EFFECT: method enables preparing the high-saponin agent possessing manifested tonic activity.
3 dwg, 5 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to pharmaceutical industry and deals with creation of medication of vegetable origin based on biologically active substances of Linaria vulgaris, which has diuretic and anticoagulation activity. Method of obtaining medication, which has diuretic and anticoagulation activity, consists in the following: extraction of milled grass of Linaria vulgaris with ethyl alcohol is carried out with successive drawing with 3 parts of extractant by method of remaceration with heating and connecting vacuum at the stage of discharge, under specified conditions.
EFFECT: method makes it possible to obtain medication, which has high diuretic and anticoagulation activity.
3 tbl, 1 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to pharmaceutical industry, in particular to method of obtaining immunotropic preparation. Method of obtaining immunotropic preparation by extraction of air-dry leaves of Lophanthus anisatus Benth with aqueous ethyl alcohol, heating, cooling, filtering, solvent evaporation, residue dissolving and extraction with chloroform, filtering and drying of sediment, under specified conditions.
EFFECT: method makes it possible to obtain efficient immunotropic medication.
3 tbl, 5 ex
SUBSTANCE: invention refers to cosmetic and pharmaceutical industry, particularly to a method for preparing a water-in-oil extract of herbs and/or flowers. The method for preparing a water-in-oil extract of herbs and/or flowers involving pre-watering or moistening of the herbal raw material in deionised water, and further extraction of the wet or swollen raw material by single-flow percolation or static mixing with an extractant presented by a water-in-oil emulsion containing oil phase 3-15 wt % specified in a group consisting of natural milk, curdy whey or a mixture thereof or a mixture thereof with milk whey under certain conditions.
EFFECT: method enables preparing the extract with the high content of biologically active substances while being highly effective and ecologically-friendly.
5 cl, 10 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, namely to a method for preparing a chromogenic complex of artist's conk. A method for preparing the chromogenic complex of artist's conk involving the staged extraction of a ground fruiting body of artist's conk in an aqueous solution of sodium hydroxide, herewith the first-stage extract and pulp are prepared at first; then the pulp is extracted to prepare the second-stage extract; the first-stage and second-stage extracts are combined, and the chromogenic complex is deposited by adding hydrochloric acid to the combined extract under certain conditions.
EFFECT: method enables providing higher yield of the end product having higher antioxidant activity.
1 tbl, 4 ex
SUBSTANCE: invention refers to pharmaceutical industry, more particularly to a method for preparing a phytopreparation of Hedysarum neglectum roots or Hedysarum theinum roots. The method for preparing the phytopreparation of Hedysarum neglectum roots or Hedysarum theinum roots by three-stage extraction of the ground roots by aqueous-alcoholic solutions at intermittent shaking at room temperature in a dark place under specific conditions.
EFFECT: invention enables optimising the method for recovering the low-molecular extractants with a maximum degree of extraction with improved pharmacological activity.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, particularly to a cardioprotective and antioxidant drug. The cardioprotective and antioxidant drug prepared by the three-staged extraction of ground tick trefoil (Hedysarum alpinum) herb in aqueous-alcoholic solutions to be randomly agitated at room temperature in a blacked-out place under certain circumstances; then the fractions are poured out and dried in a thermostat.
EFFECT: drug prepared by the above method possesses no side action and shows manifested cardioprotective and antioxidant action.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to a method for preparing a milk thistle extract having a higher degree of silymarin release. A method for preparing a milk thistle extract, wherein the extract containing 15-85 wt %, particularly 30-65 wt % of silymarin is treated with anhydrous C1-C4 alcohol, optionally filtered and concentrated, then dried and optionally ground, wherein a degree of silymarin release is 80% or higher (versions). The milk thistle extract for treating and preventing liver and gallbladder dysfunctions. A pharmaceutical composition for treating and preventing liver and gallbladder dysfunctions.
EFFECT: extract is characterised by a higher degree of silymarin release and effective for treating and preventing the liver and gallbladder dysfunctions.
8 cl, 3 dwg, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to agent possessing antiviral action, and may be used for treating herpes infections, including lip sore. The given agent contains the ingredients, wt %: a solution readily permeable through biological membranes of soapy amphiphilic complex of high-polymer RNA of Saccharomyces cerevisiae and oleic acid (as an interferon inducer) - 49.96; Vaseline oil - 20; Tween-80 - 17; Emulsifier T-2 - 13; Chlorhexidine Bigluconate - 0.04.
EFFECT: preparation shows high antiherpetic activity, good tolerability and ability to reduce a recurrence rate considerably.
SUBSTANCE: invention refers to medicine, namely to neurology, and may be used for treating spasticity accompanied by improved consciousness in the patients in the vegetative state. That is ensured by administering Xeomin (botulinumtoxinA free from complexing proteins) into the spastic muscles of all the extremities and related body segments regardless of the contractions in total dose of 400-1300 units. The dose shall not exceed 24 unit/kg of body weight in 1-3 stages. The stages follow at least every 3 days. Every 1-day stage involves administering 5-50 units in each accessible muscle or muscle group with the maximum tone in max. total dose 500 units dissolved in 12.5 unit/ml. The injections are distributed uniformly along the area without electromyography. The following courses are similar if observing spasticity and/or if clinically reasonable. The length of one course is up to 3 weeks.
EFFECT: method enables improving the therapeutic effect in the vegetative states.
3 ex, 3 tbl
SUBSTANCE: invention relates to field of cosmetology and represents preparation for removing nail polish, which contains organic solvent, cosolvents and target additives characterised by the fact that propylene glycol is used as organic solvent, mixture of ethyl alcohol, ethyl acetate, propylene carbonate, dimethyl glutarate, isopropyl alcohol are used as cosolvents, and mixture of glycerol, gelatin, jojoba oil and denatonium benzoate is used as target additive, with components in preparation being in specified wt % ratio.
EFFECT: invention ensures creation of preparation for removing nail polish without unpleasant smell, with wide spectrum of efficient effect on different types of manicure polishes, as well as characterised by restoring impact on nails, and impossibility of accidental intake as food.
SUBSTANCE: invention refers to medicine, namely to - arthrology, physiotherapy, balneology. The method involves physical methods of therapy, therapeutic exercises, massage, acupuncture and phytotherapy. The patients are trained to give a self-massage of the knee joints additionally during the resort therapy and after the termination of the rehabilitation. From the 1st to 10th day of the therapeutic course patient's knee joint is exposed to polychromatic polarised light at 20 cm for 6 minutes. The patients take 10 iodine-bromine baths at temperature 37°C for 10 minutes. From the 1st to 5th therapeutic days, the patients do combined therapeutic exercises; their lower extremities are massaged manually for 10 minutes. From the 6th to 15th days, the knee joints are exposed to sinusoid modulated currents (SMC) at modulation frequency 100 Hz, at a depth of 50 - 70%, current intensity to moderate vibration for 7 minutes. From the 6th to 10th days, the braking acupuncture follows by giving a 1-2-minute massage of the points 10RP, 9RP, 36E, 34E by introducing a needle for 30 seconds and by giving a point massage of cheng-fu, cuan, yang-lin-cuan, zu-sang-li, wei-yang, cheng-shan, chung-feng, hun-lun, nei-ting. The patients take a herbal infusion. From the 11th to 15th days, the knee joints are exposed to decimetric waves (DMW). That is followed by a hydro-massage of the lower extremities and lumbar region for 15 minutes up to 3 atm. Thereafter, the 10-minute post-isometric relaxation of the quadriceps muscle of thigh is applied. The patients do the complex of weight reduction exercises and take the herbal infusion. From the 16th to 20th day, the mud applications on the knee joints are prescribed at temperature 42°C for 30 minutes. If suffering gonarthrosis, the patients do the complex of therapeutic exercises. That is followed by the paravertebral vacuum therapy of the vertebral column. The 10-minute knee joint traction is applied. The patients take 20 g of the herbal infusion.
EFFECT: method recovers the joint mobility, improves the exercise tolerance of the lower extremities.
1 tbl, 2 ex
FIELD: food industry.
SUBSTANCE: invention relates to biotechnology and fodder production, in particular, to a method for production of a fodder additive for prevention of anima and bird mycotoxicosis. The method envisages mechanochamical treatment of the raw stock components with further granulation of the produced mixture. The components are represented by a mixture containing a mineral sorbent, hydrolised lignin and fodder yeast cell walls. The mechanochemical treatment consists in milling individual components in rotary vortex mills with an embedded particle classifier of in the components mixing and treatment in the presence of at least one compound enzyme preparation affecting hydrolised lignin residual polysaccharides and yeast cell walls polysaccharides.
EFFECT: method allows to produce a compound additive having a wide range of effects with improved efficiency of fodder mycotoxins binding, stimulating the immune system and preventing malfunctions in the animal and bird digestive tract; at the same time, combined usage of hydrolised lignin, fodder yeast and a mineral sorbent as a preventive agent with animals allows to minimise the sorbent application side effect, recover the digestive tract homeostasis and normalise metabolic indices.
15 cl, 12 tbl, 3 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, namely pharmacology and may be used for cerebral protection in treating cerebral affections. That is ensured by using Zongorine as a cerebroprotective agent.
EFFECT: agent provides the cerebroprotective action and prevents the death in animals suffering experimental post-hypoxic encephalopathy due to the activation of cerebral neutral stem cells.
2 ex, 3 tbl
SUBSTANCE: invention refers to cosmetology and represents a cosmetic skin care product in the form of a water-in-oil emulsion, containing: (A) a volatile hydrocarbon oil 3 to 25 wt %, (B) a non-volatile silicon oil 2 to 15 wt %, (C) polyethylene glycol mono- or diisostearate 0.1 to 0.8 wt % containing 4 to 12 groups of oxyethylene, (D) polyoxyethylene and polydimethyl siloxyehtyl dimethicone copolymer 1 to 5 wt %, an d (E) organically modified clay mineral 1.5 to 3 wt %; the ingredients normally introduced into the skin care products - the rest.
EFFECT: provided excellent stability and no oily, slick and creaking sensations.
6 cl, 3 ex, 4 tbl
SUBSTANCE: invention refers to cosmetology and represents a cosmetic product for lips containing the ingredients (a)-(d): (a) hydrogenised polyisobutene 10 to 30 wt %; (b) one or more methylphenylsicicones 30 to 70 wt % to be separated when mixed with (a) at 25°C specified in trimethyl pentaphenyltrisiloxane, diphenyl siloxyphenyl trimethicone, diphenyl dimethicone and phenyl trimethicone, and containing trimethyl pentaphenyl trisiloxane; (c) one or more lipophilic substrates 0.5 to 8 wt % not separated when mixed both with the ingredient (a), and with the ingredient (b) at 90°C specified in sorbitane sesquiisostearate, propylene glycol monostearate, cetyl-PEG/PPG-10/1 dimethicone and diglycerol diisostearate; and (d) wax 5 to 12 wt %.
EFFECT: provided excellent effect of second adhesion stability immediately after application, long-lasting gloss and stability.
10 cl, 22 ex, 1 dwg, 13 tbl
SUBSTANCE: invention refers to chemical-pharmaceutical industry and represents a method of delivering a substance from an antiperspirant and/or deodorant composition to an individual's axillary space, involving the application of the anhydrous antiperspirant and/or deodorant composition onto the individual's axillary space, wherein: a) the anhydrous composition contains a base and a metal-organic frame structure formed of reusable porous material (RPM) and a substance adsorbed in the metal-organic frame structure and b) the reusable porous material has a structure degradable in contact with water and releasing a substance with the metal-organic frame structure formed of the porous material (RPM) specified in a groupu consisting of [Co3(biphenyldicarboxylate)34,4'-bipyridine], [Co(biphenyldicarboxylate)(4,4'-bipyridine)], [Zn2(biphenyldicarboxylate)2 (1,2-bipyridineethene)], Mg3(O2C-C10-H6-CO2)3 and combinations thereof.
EFFECT: provided longer release of a flavouring agent after the application of the deodorant/antiperspirant to the individual by the release of the flavouring agent at the moment of perspiration.
16 cl, 2 tbl
SUBSTANCE: invention refers to cosmetic industry and represents a non-foaming cosmetic composition of an oil-in-water emulsion containing (i) retinol, (ii) at least one polar emollient specified in a group consisting of propylene glycol stearyl ester, propylene glycol isostearate and mixtures thereof (iii) at least one non-polar emollient specified in a group consisting of aromatic or linear esters, Gerbe ester, mineral oils, squalane, isohexadecane, squalene, liquid paraffin and mixtures thereof with the weight ratio of the above polar emollient and the above non-polar emollient is found within the range of approximately 95 to 5 to approximately 40 to 60.
EFFECT: provided considerable reduction of retinoid-caused skin irritation and higher efficacy or retinoid.
11 cl, 3 ex, 7 tbl, 3 dwg
FIELD: medicine, oncology, amino acids.
SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.
EFFECT: valuable medicinal antitumor properties of preparation.
8 cl, 4 tbl, 2 dwg, 4 ex