Method of producing nano-structure commercially pure titanium for biomedicine

FIELD: metallurgy.

SUBSTANCE: proposed method comprises processing the workpiece in explosive accelerator by high-velocity Ti powder particle flow in the mode of super deep penetration of particles. Note here that Ti particles are arranged under explosive with air gap. Acceleration of articles is carried out by shock wave in accelerator guide channel coupled with processed workpiece. Processing is performed by flow of particles with dispersity of 20 mcm at flow rate of 1.5-2.5 km/s, density of 1 g/cm3, pressure of collision of particles with workpiece material of 12-15 GPa and their interaction time of 5-7·10-5 s.

EFFECT: higher strength and homogeneity of titanium workpiece structure.

1 dwg

 

The invention relates to the field of nanostructure of maripipi. by processing the stream of powder particles with the energy of the explosion, high physical-mechanical and chemical properties which allow to use for medicine purposes, including implants.

Analog is the invention of nanostructured commercially pure titanium for biomedical applications [RU No. 2383654 C1, C22F 1/18 VW 3/00 2008141956/02, 22.10.2008]. The invention is implemented by processing the rod of commercially pure titanium by the method of equal-channel angular pressing (pressing) at a temperature not exceeding 450°C for 4 passes to achieve the true accumulated strain e≤4 die in a snap with the angle of the intersecting channels equal to 90°. As a result of this process the received sub-grain structure with a grain size in the range 0.5...0.7 microns.

After pressing the workpiece is subjected to a thermomechanical treatment, during which the plastic deformation with the gradual reduction of temperature in the interval 450-350°C with the total accumulated strain from 40 to 80%, and the rate of deformation varies in the range of 10-2-10-4with-1.

Thus, the result of the combined treatment in the commercially pure titanium is formed of nanocrystalline structure in which up to 90% of grains with an average size of 100-500 is m and the aspect ratio of the grains is not more than 2 in mutually perpendicular planes. The tensile strength of the obtained titanium is σB=1330 MPa, an elongation of 12%, relative narrowing of 50%.

This method has some disadvantages concerning the methods of obtaining the material. 1. The complexity of obtaining material, as technology includes 4 passes pressing, then special thermomechanical processing, 2. Additional heating of the material. 3. Complex technological equipment.

The prototype is a method of hardening of metals by processing the stream of powder particles in the regime of super-deep penetration of particles independent of the state fire [S. M. usherenko Superdeep penetration of particles in the barriers and the creation of composite materials, Minsk: Institute of pulse processes. - 1998. - p.30-31]. This method is based on the use of explosive accelerator, which is a shaped charge explosives, in the hollow of which is placed the powder. Initiating explosive accelerator generates a flow of powder particles and guides him by focusing cumulative jet directed onto the sample metal or alloy.

Features of functioning of explosive accelerator:

1. Throwing particles is a shaped charge with a cumulative cladding, and the missile powder, is cumulative seizure.

2. The particle stream is formed by focusing the cumulative page is I.

3. Processing of the matrix produced by the particles of the non-matrix material elements.

The design of the explosive accelerator, in which the powder is inside the hemispherical cumulative extraction of explosive charge, does not provide the necessary uniformity of the jet particles. Regulation homogeneity of the jet is ensured by increasing the velocity gradient, quasistability process and material handling for multiple passes.

Implementation modes of processing materials (pressure of particle collisions 10-15 HPa, the dispersion of particles of 10-100 μm, a density of about 1 g/cm3the speed of the missile particles of 1-3 km/s) provides volumetric saturation of metals and alloys elements of powder particles at depths exceeding by more than 2 orders of magnitude the size of powder particles. Penetrating particles formed in the material of the channel size of about 1 μm and nanostructuring material. The minimum size of the remaining particles of ~50 nm. Hardening action gives amorphization of microplasma (size of 10 nm or more) near the walls of the channels penetrating particles, as well as highly deformed and fragmented area around the channels with well-developed dislocation structure. Material properties greatly vary depending on the type of powder particles. Thus, when processing the titanium diboride steel 10 tordos the ü source HV140 increases to HV 240. Strength increases to 930 MPa, which is 1.4 times higher than the original. Wear resistance of hardened tool steels under conditions of shock and vibration loads increased in 1.3-1.65 times.

The proposed method of producing nanostructured commercially pure titanium for biomedical applications provides the following technical result: increased strength and uniformity of the material structure.

The technical result is achieved by processing the workpiece in an explosive accelerator high-speed flow of powder particles Ti mode superdeep penetration of particles, and the particles Ti placed under the explosive substance with an air gap, the acceleration of particles perform a shock wave in the guide channel of the accelerator, mating with the machined workpiece, while the processing is done by the particle flux particle size of 10 μm with a flow rate of 1.5-2.5 km/s, density 1 g/cm3the pressure of particle collisions with the workpiece material 12-15 GPA of time and their interaction (5-7)·10-5C.

Diagram of the device materials processing shown in Fig.1. This device includes a detonator (1) to initiate an explosive charge (2) in the shell (3). Under the explosive charge through an air gap (4) placed the capsule with the powder material (5). The formation of the stream and its orientation is sudestada in the guide channel (6), its base is joined with the treated sample source material (7).

The main differences of the operation of the proposed facility from the prototype:

1. The acceleration of particles is carried out by initiating a cylindrical charge without cumulative facing. The air gap provided in the structure directly behind the lower cut charge, contributes to the formation of the rectangular front of the shock wave. Missile powder is in accordance with the generated shock wave front is parallel to the lower edge of the charge. In order to obtain commercially pure titanium for biomedical cumulative lining of the prototype is not suitable, as it contributes to hardening of the material of the cladding. The explosive used for charging in the proposed method, to treat a group full of gas.

2. The formation of the high-speed flow of powder particles is implemented in orienting the channel.

3. Processing a matrix of titanium W 1-0 titanium powder particles.

4. Differences in 1, 2 and 3 item from the prototype provides a more uniform processing of the workpiece.

This scheme allows us to provide the necessary processing modes titanium. When the speed of the particles of 1.5-2.5 km/s and the particle flux density of Ti of about 1 g/cm3the pressure of particle collisions is OK the lo 12-15 GPA. The time of interaction of the particles with the material (5-7) 10-5spri collision of particles with VT1-0 the temperature reaches 250°C.

To obtain nanostructured commercially pure titanium was used the original samples VT1-0 with a diameter of 20 mm and height 15 mm, the Dispersion of the shot particles of titanium is 10 microns.

The resulting nanostructured fine structure of titanium grade VT1-0, the grain size of about a micrometer. Processing of materials in a mode independent of the state fire assumes that the material along with the grinding of grain, reinforced micro-channels penetrating particles, the walls of which amortizatory and are welded, which further nanostructural material and has a strengthening effect [Krivchenko A.L., Aleksentseva S.E. Peculiarities of the Dynamic Interaction Between the Directed Stream of High Speed Particles and Metals. // Shock Waves in Condensed Matter: Proc. of Int. Conf. - St. Petersburg, Russia, October 8-13, 2000, p.175-176.].

Channels penetrating particle diameter is less than 1 μm. On the walls of the channels are traces of the penetrating particles, and in the zone of inhibition recorded the remains of the penetrated particles down to 0.05 μm. The saturation concentration of a material in the channels defined in the processing of high-speed particles of titanium W 1-0 with pickle slice matrix and reaches 27.5%. The density of channels can reach 300 mm-2.

The proposed method, due to differences in the design is presented to the device from explosive accelerator prototype, provides more uniform interaction of the flow of particles from the original sample material, ensures high durability material. So, strength is increased 1.5 times. Plasticity varies slightly, elongation of 15%. The dislocation density reaches about ~1011cm-2. Microhardness N increased from the original 1900 MPa to 2600 MPa after processing the stream of powder particles.

The nanostructuring of the matrix by processing high-speed flow of powder particles of titanium may provide for any technical grades of titanium: W 1-0, W 1-00 to the pure iodide titanium, as well as the number of brands used in medicine Grade 1 - Grade 4. The purpose of hardening was used brand titanium, relatively low strength characteristics, as W 1-0.

We offer machining of commercially pure titanium flow of particles Ti (pair Ti → Ti) provides the obtaining of nanostructured commercially pure titanium and the possibility of applying for the purposes of Biomedicine. Commercially pure titanium is one of the most suitable material for the manufacture of implants, which is well merges with the living tissues and is currently used for long-term presence in the human body. The application of such implants hung the t on the strength and durability of the material. Therefore, the enhancement of the mechanical properties of titanium without the introduction of additional alloying elements such as vanadium, chromium alloys Ti5Al12.5Sn, Ti5Al13V11Cr [D.M. Brunette, P. Tengvall, M. Textor, P. Thomsen, "Titanium in medicine". Springer (2001), p.1019], which reduce the biocompatibility and contribute to the accumulation of toxic elements, is the goal of the proposed method.

The method of obtaining nanostructured commercially pure titanium for biomedical applications, including the processing of the workpiece in an explosive accelerator high-speed flow of powder particles Ti mode superdeep penetration of particles, and the particles Ti placed under the explosive substance with an air gap, the acceleration of particles perform a shock wave in the guide channel of the accelerator, mating with the machined workpiece, while the processing is done by the particle flux particle size of 10 μm with a flow rate of 1.5 to 2.5 km/s, density 1 g/cm3when the pressure of particle collisions with the workpiece material 12-15 GPA and time of their interaction 5-7·10-5C.



 

Same patents:

FIELD: metallurgy.

SUBSTANCE: high-strength pseudo-beta titanium alloy contains the following, wt %: aluminium 5.3-5.7, vanadium 4.8-5.2, iron 0.7-0.9, molybdenum 4.6-5.3, chrome 2.0-2.5, oxygen 0.12-0.16, and titanium and impurities are the rest, and when necessary, one or more additional elements chosen from N, C, Nb, Sn, Zr, Ni, Co, Cu and Si; with that, each additional element is present in the amount of less than 0.1%, and total content of additional elements is less than 0.5 wt %. At production of alloy, after it is obtained, homogenisation is performed at the temperature below temperature of beta-conversion and its disperse strengthening. An aviation system component represents a landing gear or a fastening part, which is made using titanium alloy.

EFFECT: alloy has high strength,ductility and ability for deep hardening.

25 cl, 4 dwg, 3 tbl, 3 ex

FIELD: metallurgy.

SUBSTANCE: method of processing the titanium alloy consisting of, at least, the following components, in wt %: iron - 0.2-0.5, oxygen - 0.02-0.12, silicon - 0.15-0.6, titanium and unavoidable impurities making the rest, comprises executing the first thermal treatment at first temperature to form the structure containing 50% of beta-phase, and, then, cold rolling. Second thermal treatment at second temperature is executed to produce second-phase precipitation while third thermal treatment is performed at third temperature for alloy recrystallisation without dissolution of precipitation.

EFFECT: high-strength titanium alloy with high resistance to oxidation and pliability at low temperatures.

18 cl, 6 dwg

FIELD: metallurgy.

SUBSTANCE: proposed method comprises hot forming of slab, hot rolling and teat treatment of plate, whereat hot forming if carried out in one step. Immediately after reaching required thickness in slab forming it is quickly cooled to the depth of 20-30 mm at the rate of at least 50°C/min. Subsequent hot lengthwise rolling at performed at first step in α+β-area by partial reduction with deformation degree εi varying from 3% to 5% to total deformation ε=25…30% with breaks between passes of 8 to 12 s. At second step, it is performed in β-area from heating temperature determined by definite formula. At the next step rolling is performed in α+β-are with breaks and heating in lengthwise or transverse directions with total degree of deformation e after every break to 60%.

EFFECT: homogeneous fine-grain microstructure, high and stable mechanical properties, high precision, no surface defects.

FIELD: metallurgy.

SUBSTANCE: soaking is done at heating temperature for 10-15 minutes, and cooling is done in a coolant with speed of 300°C/s, afterwards ageing is done under load at 18-25°C, stress not exceeding yield point at ageing temperature, and time required to achieve stable speed of relaxation process.

EFFECT: increased strength of titanium of BT1-0 grade in combination and higher plasticity during treatment of items from titanium BT1-0, including heating, is carried out to temperature exceeding temperature of polymorphous transformation.

1 tbl, 1 ex

FIELD: metallurgy.

SUBSTANCE: invention refers to nanostructured materials with ultra-fine grain structure, and namely two-phase alpha-beta titanium alloys which can be used for manufacture of semi-finished products and products in different branches of engineering, machine-building industry and medicine. Proposed alloy has microstructure consisting of ultra-fine grains of alpha-phase and beta-phase with the size of less than 0.5 mcm. In alloy microstructure the amount of grains with grain shape coefficient of not more than 2 is not less than 90%; at that, more than 40% of grains have wide-angle borders, and average density of dislocation is not more than 1014 m-2. the method for obtaining ultra-fine grain two-phase alpha-beta titanium alloy involves heat treatment with heating of a billet at the temperature of not more than 0.6 T"пп", further multicycle intense plastic deformation with achievement of accumulated true deformation degree e≥4. Then, plastic deformation is performed so that the billet shape is changed at the rate of less than 10-1 s-1 in several cycles to provide deformation degree ε≥50%.

EFFECT: improving strength and fatigue properties and preserving high ductility.

5 cl, 2 dwg, 1 tbl, 1 ex

FIELD: process engineering.

SUBSTANCE: invention relates to metallurgy and may be used at making rods with heads from titanium alloys. Billets are subjected to thermal treatment to perform hot heading. After heading thread is cut and head fillet is hardened. Thread is cut in two steps. First, preliminary incomplete knurling is performed after tempering of billets with deformation. Said deformation is defined by percentage between formed tooth thread depth to required depth to make 85-98%. Then workpiece is age-hardened to perform final thread cutting.

EFFECT: high strength bolts from titanium alloys with flaw-free thread, lower production costs.

3 cl, 1 tbl, 6 ex

FIELD: metallurgy.

SUBSTANCE: invention relates to production of thin sheets from ingot of pseudo-alpha titanium alloy. Proposed method comprises forming ingot of alloy Ti-6.5Al-2.5Sn-4Zr-1Nb-0.7Mo-0.15Si into slab and machining of the latter. Then, said slab is heated to temperature exceeding that of polymorphic transition, deformation and multistep rolling to semi-finished rolled stock with regulated total degree of deformation and degree of deformation in a pass. Sheets are stacked, stacks are rolled to finished size and subjected to multipass rolling with regulated total deformation, sheets are extracted from the stack and subjected to finishing.

EFFECT: high and uniform strength and plastic properties.

1 dwg, 2 tbl

FIELD: metallurgy.

SUBSTANCE: sheet is made from pure titanium and contains titanium and unavoidable impurities. It features yield point of 215 MPa or higher, mead size d of the grain making 25 mcm of larger and 75 mcm or smaller, and hexagonal crystalline structure. Appropriate grains in hexagonal crystalline structure feature means Schmidt factors (SF) of twins 11-22 with rolling direction oriented along their axes. Means Schmidt factor (SF) and grain means size d satisfy the following relationship: 0.055≤[SF/√d]≤0.084. Heat exchanger plate comprises sheet of pure titanium and as integral component.

EFFECT: high ductility and strength, heat exchange plate with such sheet.

2 cl, 6 dwg, 3 tbl

FIELD: metallurgy.

SUBSTANCE: method to produce a blank of a blade of gas turbine engines (GTE) with ultra-fine grain structure from titanium alloys includes preliminary heating of the blank to temperature below temperature of polymorphous conversion and treatment by means of multiple intensive plastic deformation with changing of deformation directions in several cycles. Treatment is carried out under isothermic conditions at identical temperature of the blank and the punch. In each cycle deformation is carried out at temperature of alloy annealing according to stages, which include setting of the cylindrical blank in the closed punch, open setting with production of the blank in the form of a disc, flattening to the disc rib in the closed punch for production of the blank with the square section, its setting in the closed punch to the cylindrical blank. Number of treatment cycles is determined based on achievement of the extent of accumulated deformation of at least five. Then closed setting of the blank is carried out at the temperature of 50-100°C below the alloy annealing temperature, squeezing into the cylindrical blank, having two different diameters of cross section for a blade foot and airfoil, and flat stamping of the blade blank.

EFFECT: homogeneous ultra-fine grain structure is produced in a blade blank, providing for high physical and mechanical and operating properties of a blade.

2 dwg

FIELD: metallurgy.

SUBSTANCE: thermomechanical device includes a working member made in the form of one pre-deformed element or several pre-deformed and parallel and/or in-series connected elements from alloy based on titanium with shape memory effect. The working member is made in the form of a rod with working part of cylindrical or rectangular shape and fixing parts in the form of expansions on the rod ends, the sectional area of which is at least by five times more than the sectional area of its working part.

EFFECT: achieving maximum possible translational relative movements of the member at variation of its temperature at the temperature interval of reverse martensitic transformation of material.

6 dwg, 1 ex

FIELD: metallurgy.

SUBSTANCE: producing method of monophasic nanocrystalline silicon-replaced hydroxyapatite involves synthesis of silicon-containing hydroxyapatite by means of a method for deposition from water solution of reagents containing orthophosphoric acid, calcium hydroxide and tetraethyl orthosilicate at pH of not less than 9 and molar ratio of Ca/P in the range of 2.0 to 2.5; sedimentation for completion of a phase formation process, extraction of deposit, drying and heat treatment of deposit; with that, synthesis is performed by adding 10-20% solution of orthophosphoric acid at the speed of 0.2-0.8 ml/min per litre of water solution of calcium hydroxide / tetraethyl orthosilicate composition prepared by means of 0.08-0.16% water solution of calcium hydroxide and design amount of tetraethyl orthosilicate to obtain a finished product with silicon replacement degree x equal to 1-2 and molar ratio of Ca/(P+Si), which is close to 1.67, and heat treatment is performed at the temperature of not lower than 300°C, but not higher than 400°C. Invention allows obtaining stoichiometric monophasic product of phases with average size of crystals of 9.95-12.53 nm, specific surface of 108.97-132.58 m2/g, and increased bioactivity, at the heating of which incidental phases do not occur.

EFFECT: improvement of characteristics.

4 dwg, 2 tbl, 8 ex

FIELD: chemistry.

SUBSTANCE: luminescent composite material contains a polymer base 1 made of an optically transparent polymer material and a phosphor-containing multilayer polymer film consisting of three layers: optically transparent polymer film 2; polymer composition 3, including an inorganic phosphor - cerium-doped yttrium-aluminium garnet, or cerium-doped gallium-gadolinium garnet; polymer composition 4 with dispersed semiconductor nanocrystals made of a semiconductor nucleus, first and second semiconductor layers, and emitting a fluorescent signal with fluorescence peaks in the wavelength range of 580-650 nm. Layers of the multilayer polymer film can also be arranged in the following order: polymer composition 3 containing a phosphor, polymer composition 4 with dispersed semiconductor nanocrystals, optically transparent polymer film 2. The light-emitting device contains a luminescent composite material situated away from a light source. The light source is in form of a light-emitting diode with radiation wavelength of 430-470 nm. The light-emitting devices have service life longer than 50000 h, luminous efficacy higher than 100 lm/W and correlated colour temperature of 2500-5000 K.

EFFECT: invention enables to obtain white light with colour rendering index of more than 80.

48 cl, 14 dwg

FIELD: chemistry.

SUBSTANCE: method involves preparing a nanosuspension by adding carbon nanotubes to a reactive plastic binder with ultrasonic exposure in a cavitation zone with intensity of 15-25 kW/m2. Carbon nanotubes are dispersed in the binder with simultaneous photographic recording of changes in colour intensity of the nanosuspension. When the nanosuspension reaches colour intensity values corresponding to standardised dispersion values in the range of 0.9 to 0.99, ultrasonic exposure is stopped.

EFFECT: method enables to optimise dispersion of carbon nanotubes in the binder and cut the duration of preparing high-strength nanocomposites owing to uniform distribution of nanoparticles in the nanocomposite.

3 dwg

FIELD: chemistry.

SUBSTANCE: invention relates to obtaining biocompatible magnetic nano-particles and can be applied for therapeutic purposes, in particular, for fighting cancer. Method of obtaining nano-particles, including iron oxide and silicon-containing casing and having value of specific absorption rate (SAR) 10-40 W per g of Fe with field strength 4 kA/m and frequency of alternating magnetic field 100 kHz, contains the following stages: A1) preparation of composition of at least one iron-containing compound in at least one organic solvent; B1) heating of composition to temperature in range from 50°C to temperature 50°C lower than temperature of reaction of iron-containing compound according to stage C1 for minimal period 10 minutes; C1) heating composition to temperature between 200°C and 400°C; D1) purification of obtained particles; E1) suspending purified nano-particles in water or water acid solution; F1) addition of surface-active compound to water solution, obtained according to stage E1); G1) processing of water solution according to stage F1) by ultrasound; H1) purification of water dispersion of particles, obtained according to stage G1); I1) obtaining dispersion of particles according to stage H1) in mixture of solvent from water and water-mixable solvent; J1) addition of alkoxysilane into dispersion of particles in mixture of solvent according to stage I1); and K1) purification of particles.

EFFECT: invention makes it possible to obtain biocompatible magnetic particles with high value of specific absorption rate (SAR).

42 cl, 3 dwg, 9 ex

FIELD: chemistry.

SUBSTANCE: invention can be applied in production of transparent electrodes and instruments of nano-electronics. Graphene film is obtained by sedimentation of carbon from carbon-containing gas in vacuum on catalyst-covered substrate, preliminarily heated to temperature, which exceeds carbon-containing gas decomposition. Carbon-containing gas is supplied to pressure 1-10-4 Torr. Exhaustion of reactor is carried out 1-300 s after supply of carbon-containing gas with its simultaneous cooling to room temperature at rate 10-100°/min. As carbon-containing gas, taken is gas, selected from the group: acetylene, methane, ethane, propane, butane, ethylene, hexane or combination of said gases with inert gas. As catalyst, applied is metal, selected from the group: Fe, Ni, Cu or combination of metals, which includes at least two of upper mentioned metals. Catalyst film is 1-5000 nm wide.

EFFECT: invention ensures obtaining graphene film by simple and technological method.

9 cl, 6 dwg, 14 ex

FIELD: chemistry.

SUBSTANCE: invention can be applied in electro-chemical and electro-physical devices. Anodic galvanostatic polarisation of titanium and zircon is performed with current density from 0.1 to 3.0 mA·cm-2 in liquor of chlorides of alkaline metals, with contain from 0.1 to 1.0 wt % of boron carbide powder at temperature 843-873 K in argon atmosphere.

EFFECT: simplification of defect-free monolayer and poly-layer films of graphene of large area with increase of monolayer graphene output.

3 dwg, 1 tbl

FIELD: process engineering.

SUBSTANCE: invention relates to inorganic chemistry, particularly to production of powders to be used in laser technology and optical instrument making. Proposed method comprises preparation of blend and its thermal treatment. Said blend is prepared from the powder of sesquialteral rare-earth element sulphides with particle size of 1-30 mcm and powder of rare-earth element trifluorides with particle size of 10-70 nm at molar ratio of 1:1.Thermal treatment of the blend is conducted at 650-800 °C for 20-30 minutes in atmosphere of argon, sulfiding gases H2S+CS2 and fluoridiser gases C2F4, CF4 obtained in Teflon pyrolysis.

EFFECT: homogeneous phase powders.

2 ex

FIELD: medicine.

SUBSTANCE: invention refers to pharmaceutical industry and represents a method for introducing gold nanoparticles into the body by the local skin application, differing by applying the preparation of the following composition: 96% dimethyl sulphoxide 0.1 ml per a gel base 1 ml with gold nanoparticles d=140 nm, or the preparation of the following composition: 20% thiophane sulphoxide 0.1 ml per a gel base 1 ml with gold nanoparticles d=40 nm; the skin areas coated with gold nanoparticles in complex with organic sulphur compounds shall be exposed to ultrasound at frequency 1 MHz, power 2 Wt and length 2 minutes.

EFFECT: invention provides higher transdermal permeability of gold nanoparticles and no nanoparticle accumulation in the internal organs.

8 dwg

FIELD: machine building.

SUBSTANCE: piston pin is installed in a piston hole and a piston-rod is installed on the piston pin. First, onto the steel piston pin surface there mechanically applied is mechanically activated powder from material based on nickel with shape memory effect with the particle size of 30-50 mcm by plasma sputtering in vacuum so that a layer 0.2-3 mm thick is obtained. Then, vacuum annealing of the applied layer is performed at the temperature of 500-800°C, thermomechanical treatment is performed at heating to 30 to 250°C or at cooling to -10÷0°C by means of liquid nitrogen and at running-in of the applied layer at that temperature with rollers in radial direction per 50-70 passes with accumulation of deformation degree of ε ≥ 3.7%. Then, after the piston pin is installed into the piston hole, heating of the connection is performed to 20.7-325.8°C of the end of reverse martensitic transformation.

EFFECT: improving strength characteristics of a piston-rod and piston assembly.

6 cl, 1 dwg, 1 tbl, 3 ex

FIELD: metallurgy.

SUBSTANCE: strengthening nanodisperse particles of zirconium oxide is introduced to molten metal based on aluminium-magnesium alloy. Molten metal is crystallised in a centrifuge field with gravitation coefficient of 150-200 g and molten metal life cycle of 8-10 sec/kg.

EFFECT: production of gradient material with spatially non-homogeneous structure and high properties.

3 cl, 1 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine and deals with nanoliposome which includes liposomal membrane, contains ethgerificated lecitin and one or more physiologically active ingredients, incorporated in the internal space of liposomal membrane, method of obtaining such, as well as composition for prevention or treatment of skin diseases, containing nanoliposome.

EFFECT: invention ensures long-term stability and homogenecity of nanoliposomes.

15 cl, 22 ex, 4 dwg, 2 tbl

Up!