Cosmetic product for lips

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology and represents a cosmetic product for lips containing the ingredients (a)-(d): (a) hydrogenised polyisobutene 10 to 30 wt %; (b) one or more methylphenylsicicones 30 to 70 wt % to be separated when mixed with (a) at 25°C specified in trimethyl pentaphenyltrisiloxane, diphenyl siloxyphenyl trimethicone, diphenyl dimethicone and phenyl trimethicone, and containing trimethyl pentaphenyl trisiloxane; (c) one or more lipophilic substrates 0.5 to 8 wt % not separated when mixed both with the ingredient (a), and with the ingredient (b) at 90°C specified in sorbitane sesquiisostearate, propylene glycol monostearate, cetyl-PEG/PPG-10/1 dimethicone and diglycerol diisostearate; and (d) wax 5 to 12 wt %.

EFFECT: provided excellent effect of second adhesion stability immediately after application, long-lasting gloss and stability.

10 cl, 22 ex, 1 dwg, 13 tbl

 

RELATED APPLICATIONS

This application claims priority under Japanese patent application No. 2009-272008, filed November 30, 2009, and Japanese patent application No. 2009-281965, filed December 11, 2009, which are incorporated in this application by reference.

The SCOPE of the INVENTION

The present invention relates to a cosmetic treatment for the lips and, in particular, relates to a cosmetic treatment for the lips, having excellent effect of resistance to secondary adhesion immediately after application, and has excellent durability and gloss stability.

PRIOR art

In conventional cosmetics for lips, there is the problem of secondary adhesion, namely, lipstick is moved into place in contact with the lips (e.g., a Cup), after lipstick applied to the lips. In contrast, developed products for the lips, with a so-called effect of resistance to secondary adhesion, which causes a small secondary adhesion.

For example, in patent document 1 is disclosed a cosmetic composition that is resistant to migration, comprising: a volatile hydrocarbon solvent; a non-volatile silicone compound which can be dissolved or dispersed in a volatile hydrocarbon solvent; and non-volatile hydrocarbon oil, is AutoRAE dissolved in a volatile solvent and incompatible with the non-volatile silicone compound, where non-volatile hydrocarbon oil has a certain solubility parameter.

However, this cosmetic composition that is resistant to migration has free space for improved stability and lacks luster. In addition, the effect of resistance to secondary adhesion takes some time after application. Because of the volatile oil component is contained as an essential component, there is a problem in that some restrictions are imposed on the container.

In patent document 2 is disclosed composition lipstick resistant to the transfer of containing non-volatile oil perforating type and volatile oil, which are incompatible with each other. In this patent literature 2 oil separated during deposition on a substrate with the transition to the first song.

However, the effect of resistance to secondary adhesion of this composition lipstick takes some time after application. Because of the volatile oil component is contained as an essential component, there is a problem in that some restrictions are imposed on the container.

In patent document 3 is disclosed pencil cosmetic resistant to the transfer of containing volatile oil and a silicone surfactant, depigment favorably dispersed.

However, this pencil cosmetic product contains a high proportion of volatile oil in the composition and, therefore, has the disadvantage that its matte finishing touch tends to give a feeling of dryness on the lips.

In patent document 4 disclose a single-phase composition for lipsticks containing volatile oil and a silicone resin.

However, after evaporation of volatile oils, the composition for lipsticks tend to cause dryness over time, although it has improved resistance to migration. In addition, the film of the resin remains on the lips. In addition, this composition has the following disadvantages in that it evokes the feeling of the film and tension, and the resulting adhesion is matte.

In patent document 5 discloses the composition in the form of emulsions of oil-in-oil containing: oil dispersing medium containing silicone covering agent, volatile silicone oils, non-volatile liquid silicone oil and an emulsifying agent; and a dispersed oil phase containing essential oil and coloring matter, where the number in a mixture of oil dispersing medium and dispersed oil are in the ratio of the dispersed oil phase(oil dispersed phase and oil dispersant environment)of from 0.05 to 0.5.

However, it can be difficult to maintain the composition in the form of what mulshi oil-in-oil in the preservation of temporal stability. In addition, the effect of resistance to secondary adhesion takes some time after application. Because of the volatile oil component is contained as an essential component, there is a problem in that some restrictions are imposed on the container.

Patent literature 1: Publication of unexamined Japanese patent application No. 2001-199846

Patent literature 2: unexamined Publication of international patent application No. 96/40044

Patent literature 3: Publication pending international patent application No. 97/16157

Patent literature 4: Publication of unexamined Japanese patent application No. H9-48709

Patent literature 5: Publication of unexamined Japanese patent application No. 2000-53530

Description of the INVENTION the TASK THAT SHOULD BE SOLVED by the INVENTION

The present invention was made in light of the above conventional technology. The aim of the invention is to develop beauty products for lips, which has an excellent effect of resistance to secondary adhesion immediately after application and has excellent resistance Shine after application and stability.

MEANS of SOLVING the PROBLEM

The authors of the present invention conducted a thorough investigation; as a result, the authors of the present invention it was found that somaticheskoe tool for lips, with the effect of the resistance to secondary adhesion immediately after application without loss of gloss, can be obtained by the use of a particular oil component and by mixing certain lipophilic surfactant and wax.

Thus, cosmetic lip of the present invention is characterized by the content of the following components (a)to(d):

(a) from 10 to 30 wt.% hydrogenated polyisobutene;

(b) from 30 to 70 wt.% one or more kinds of methylphenylsiloxane who separate when mixed with (a) at 25°C;

(c) from 0.5 to 8 wt.% lipophilic surfactant, which is not separated as when mixed with component (a), and when mixed with component (b) at 90°C; and

(d) from 5 to 12 wt.% the wax.

Preferably, in the cosmetic tool lip contained dye.

Preferably, in the cosmetic tool lip as the coloring matter contained pearlescent agent, treated silicone.

Preferably, in the cosmetic tool lip component (C) represented one or more kinds selected from sorbitan of sesquiisostearate, of propylene glycol monostearate, cetyl-PEG/BCP-10/1 dimetikona and digitaldisaster.

Preferably, in the cosmetic tool for lip ratio of the components of the mixture (mass ratio) of the component (a) and component (b) was as follows: the component (b)/component (a)=1.1 to 6.

Preferably, in the cosmetic tool lip component (b) contains three methyl Pentagon ultrasil the ocean.

Preferably, in the cosmetic tool lip component (b) contained definitiondefinition.

Preferably, in the cosmetic tool lip mix the number of definitiondefinition ranged from 1 to 17 wt.% relative to the overall number of cosmetic products.

Preferably, in the cosmetic tool lip contained a volatile silicone oil and water or glycerin.

Preferably, in the cosmetic tool lip containing definitiondefinition, do not contain volatile oil component.

In addition, it is preferable that the cosmetic lip of the present invention contain the following components (a)to(d) and does not contain volatile oil component:

(a) from 10 to 30 wt.% hydrogenated polyisobutene;

(b) from 30 to 70 wt.% more than two kinds of methylphenylsiloxane who separate when mixed with (a) at 25°C (however, it contains from 1 to 17 wt.% definitiondefinition relative to the total number of cosmetic products);

(c) from 0.5 to 8 wt.% lipophilic surfactant, which is not separated as when mixed with component (a), and when mixed with to what nonantum (b) at 90°C; and

(d) from 5 to 12 wt.% the wax.

In addition, it is preferable that the cosmetic lip of the present invention contain the following components (a)to(d), from 3 to 15 wt.% volatile silicone oil and from 3 to 12 wt.% water and/or glycerol:

(a) from 10 to 25 wt.% hydrogenated polyisobutene;

(b) from 30 to 65 wt.% one or more kinds of methylphenylsiloxane who separate when mixed with (a) at 25°C;

(c) from 2 to 7 wt.% digitaldisaster; and

(d) from 5 to 12 wt.% the wax.

The EFFECT of the INVENTION

Cosmetic lip resistant secondary adhesion immediately after application, resistance, gloss and good stability can be obtained by mixing specific amounts of (a) hydrogenated polyisobutene, (b) one or more kinds of methylphenylsiloxane who separate when mixed with (a) at 25°C, (C) lipophilic surfactant, which is not separated as when mixed with component (a), and when mixed with component (b) at 90°C, and (d) of wax.

A BRIEF DESCRIPTION of GRAPHIC MATERIALS

Figure 1 shows the effect of resistance to secondary adhesion cosmetics lip of the present invention.

The BEST WAY of carrying out the INVENTION

In the present invention by mixing the hydrogenated polyisobutene the a and methylphenylsiloxane(s), which are incompatible with each other, get a cosmetic emulsion oil-in-oil where methylphenylsiloxane(s) forms a continuous phase, dye and hydrogenated polyisobutene form a disperse phase and the lipophilic surfactant is present on the surface. Due to the fact that silicone oil is separated in the surface layer on the lip after application, provides Shine. And hydrogenated polyisobutene in the inner layer keeps the dye. In this case, the silicone oil is separated in the surface layer during application due to the fact that the difference of viscosity between the continuous phase and the dispersed phase is high; therefore, the effect of stability to the secondary adhesion is achieved immediately.

Next, each component is described in detail.

((and) Hydrogenated polyisobutene)

Hydrogenated polyisobutene (a)used in the present invention is an oil component that is kept firmly on the lip and insoluble in component (b), which is the oil component of the continuous phase. Preferably, the average molecular weight hydrogenated polyisobutene ranged from 1000 to 2650.

It is necessary to mix the amount of hydrogenated polyisobutene (a) ranged from 10 to 30 wt.% relative to the General to whom icesta cosmetics. This blend quantity is preferably from 12 to 25 wt.%, and particularly preferably from 12 to 20 wt.%. If the blend quantity is too large, the effect of stability to the secondary adhesion is not achieved, as a cosmetic, it is difficult to separate during application. If it is too small, the effect of resistance to secondary adhesion is not achieved, because cosmetic is not separated when applied.

Hydrogenated polyisobutene and oil component of the continuous phase are poorly mixed. Therefore, even when mixed with other non-volatile oil components, the state of phase separation can be maintained in the used temperature range, if the number is within a certain range. Accordingly, non-volatile oil components that are compatible with hydrogenated polyisobutene, you can mix in this range, in order to maintain the separation of the phases, and in such a range that the effect of resistance to secondary adhesion is not violated. As such oil components, you can use oil ingredients usually used in cosmetics for lips. Examples of such oil components include liquid petrolatum, squalane, glycerylmonostearate, trimethylolpropane-three-2-utilisateurs, isopropylmyristate, cetyl-2-this is hexanoate, glycerylmonostearate, 2-heptylaniline, methylpolysiloxanes, glycerylmonostearate and disasterrelated to be selected one or more of these oils.

((b) Methylphenylsiloxane)

Methylphenylsiloxane (b)used in the present invention, is separated when mixed with hydrogenated polyisobutene (a) at 25°C. When the cosmetic lip of the present invention where the use of such a component (b), applied on the lips, the component (a) and component (b) are separated by contact cosmetics for lips and lip. In the component (a) is kept on the lips, and the component (b) is separated into the surface layer; therefore, the effect of resistance to secondary adhesion. When such a cosmetic lip sticks to the material, the material adheres only transparent component (b). In addition, since there are a large quantity of the component (b), component (b) is again separated in the surface layer of the contact material and lips. Therefore, for cosmetics lip of the present invention the effect of resistance to secondary adhesion can be achieved for a long time.

Methylphenylsiloxane (b)blended in the cosmetic tool for lip according to the present invention may be one kind or a mixture of two or more kinds

In this case, the presence or absence of "separation" was measured under the conditions described below.

(Measuring conditions)

(a) and (b) used in the ratio ((a):(b)=1:3 (mass ratio)) was heated to 90°C. After the mixture was mixed under stirring, it was allowed to stand at 25°C. When the surface of the section was uniformly distributed into two layers, it was called "split". When the mixture was in a semi-transparent state or in an apparently mixed condition with no surface section, it was called "undivided".

Trimethylenetrinitramine preferred as methylphenylsiloxane (b)blended in the cosmetic agent according to the present invention. Especially preferably contained 50 wt.% trimethylenetrinitramine or more relative to the total number of methylphenylsiloxane (b).

Examples of trimethylenetrinitramine include methylphenylsiloxane FZ3156 (165 mm2/s (25°C), made by the company Dow Corning Toray Co., Ltd.).

Definitiondefinition also preferred as methylphenylsiloxane (b)blended in the cosmetic agent according to the present invention. In the mixing definitiondefinition Shine when applying improved to a greater extent. As definitiondefinition especially site is preferably used one which has a viscosity of from 10 to 25 mm2/s (25°C). Examples of definitiondefinition include silicone KF3156 (14 mm2/s (25°C), made by the company Shin-Etsu Chemical Co., Ltd.)).

Mix the number of definitiondefinition is preferably from 1 to 17 wt.% relative to the overall number of cosmetic products, and particularly preferably from 5 to 10 wt.%. If the number of definitiondefinition is less than 1 wt.%, cosmetic product can be separated, because the compatibility of the material may be weak. If it exceeds 17 wt.%, the effect of resistance to secondary adhesion may not be reached because the cosmetic product may not be separated after application.

As component (b) in a mixture of cosmetics lip of the present invention, as described above components, you can use diphenylmethan (for example, silicone KF54 (400 mm2/s (25°C), made by the company Shin-Etsu Chemical Co., Ltd.), silicone KF50-300CS (270-330 mm2/s (25°C), made by the company Shin-Etsu Chemical Co., Ltd.), silicone KF-54HV (5000 mm2/s (25°C), made by the company Shin-Etsu Chemical Co., Ltd.)), fenitrothion (for example, silicone SH556 (22 mm2/s (25°C), made by the company Dow Corning Toray Co., Ltd.)), and the like.

Blend quantity of the component (b) is from 30 to 70 wt.% regarding the preliminary total number of cosmetic products, and preferably from 40 to 60 wt.%. If the blend quantity of the component (b) is less than 30 wt.%, the effect of stability to the secondary adhesion is not achieved, because cosmetic hardly separated after application. If it exceeds 70 wt.%, the effect of stability to the secondary adhesion is not achieved, because the reduced mixed number hydrogenated polyisobutene.

In the present invention it is preferable that the mixing ratio (mass ratio) of the component (a) and component (b) was as follows: the component (b)/component (a)=1.1 to 6. If the component (b)/component (a) is less than 1.1, the effect of resistance to secondary adhesion may not be reached because cosmetic hardly separated after application. If it exceeds 6, the effect of resistance to secondary adhesion may not be reached because of the mixed number hydrogenated polyisobutene may be too low.

((C) Lipophilic surfactant)

You need to lipophilic surfactant used in the present invention, not separated as when mixed with component (a), and when mixed with component (b) at 90°C. by mixing such a lipophilic surfactant can be obtained a stable cosmetic for the lips, mixing incompatible component (a) and comp the element (b).

In this case, the presence or absence of "separation" was measured under the conditions described below.

(Measuring conditions)

(C) and (a) used in the ratio ((C):(a)=1:1 (mass ratio))was heated to 90°C and mixed with stirring. When the specific surface area was uniformly distributed into two layers, it was called "split". When the mixture was in a semi-transparent state or in an apparently mixed condition with no surface section, it was called "undivided".

Relationship with (b) are such as described above.

Lipophilic surfactant, are mixed in the present invention may be one kind or a mixture of two or more kinds.

Particularly preferably, the lipophilic surfactant was not separate when mixed with (a) at 25°C and separated when mixed with (b) at 25°C.

Sorbitan sesquiisostearate, the propylene glycol monostearate, cetyl-PEG/BCP-10/1 Dimethicone and diglycidylethers preferred as a lipophilic surfactant (C)blended in the cosmetic tool for lip according to the present invention.

As commercially available sorbitan of sesquiisostearate can lead ESTEMOL 182V (manufactured by the firm of The Nisshin OilliO Group, Ltd.). As commercially available propylene glycol monostearate of you can lead Nikkol PMS-SEN (manufactured by the company Nikko Cemicals Co., Ltd.). As a commercially available cetyl-PEG/BCP-10/1 dimetikona can lead ABIL EM (manufactured by the company Evonik Degussa Japan Co., Ltd.). As commercially available digitaldisaster can lead WOGEL-18DV (manufactured by the company MATSUMOTO TRADING Co., Ltd.).

Blend quantity of the component (C) is from 0.5 to 8 wt.% relative to the overall number of cosmetic products, and preferably from 1 to 5 wt.%. If the blend quantity of the component (C) is less than 0.5 wt.%, the compatibility of the material is weak, therefore, the cosmetic product is divided. If it exceeds 8 wt.%, the effect of stability to the secondary adhesion is not achieved, because cosmetic is not shared after application.

When a valid mixed amounts of the respective components (a)to(C) is heated to 90°C and mixed with stirring, preferably formed of a translucent state or obviously mixed condition with no surface section, namely the above "unshared" condition.

(d) Wax)

The wax component (d)blended in the cosmetic tool for lip according to the present invention is not specifically limited, if it can usually be added in the mixture for cosmetics.

In the present invention the solid cosmetic lip oil-in-oil where methylphenols the likon (b), that is, a liquid oil component, which typically has a lower viscosity than the component (a)constitutes the external phase can be obtained by mixing the wax (d). That is, it is preferable that the wax used in the present invention, was compatible with methylphenylsiloxane.

Examples of the waxes used in the present invention include Carnauba wax, candelilla wax, polyethylene wax, beeswax, ceresin, microcrystalline wax, paraffin wax and Japan wax. From waxes preferred microcrystalline wax and polyethylene wax.

Blend quantity of the component (d) is from 5 to 12 wt.% relative to the overall number of cosmetic products, and preferably from 6 to 11 wt.%. If the blend quantity of the component (d) is less than 5 wt.%, curing is difficult. If it exceeds 12 wt.%, the ability to spreading loss, and the luster is lost.

In the present invention, it is preferable to mix the dye in addition to the above essential components (a)to(d). Examples of the coloring substances include substances which are usually used in cosmetics for lips.

Such dyes may be in powder form or in the form of a varnish (containing oil), if they are painting what they substances, commonly used in lipsticks. They can be inorganic pigments, organic pigments or agents with pearl effect. Inorganic pigments, organic pigments or agents with pearl effect all are to a greater extent oil wetted component of the dispersed phase component (a))than the oil component of the continuous phase (component (b)). Accordingly, the coloring matter spontaneously moves in the oil component of the dispersed phase. Therefore, when applying cosmetics dye is retained in the hydrogenated polyisobutene (a) and is present on the inner side of the component (b) of the surface layer; thus, the secondary adhesion occurs with difficulty.

When the pearlescent agent is mixed as the coloring matter, it is preferable to mix the pearlescent agent is treated with silicone. Because they use pearlescent agent, treated with silicone, dye easily dispersed in the manufacturing process.

When using the pearlescent agent, treated with silicone, it is wetted with an oil component of the continuous phase (component (b)). However, when applying cosmetics pearlescent agent is moved to the component (a), because this pearlescent agents who usually has a high aspect ratio. Therefore, even when the pearlescent agent, treated with silicone, mixed in cosmetic tool according to the present invention, the effect of stability to the secondary adhesion is excellent.

Mix the amount of the coloring matter is preferably from 3 to 15 wt.% relative to the overall number of cosmetic products, and particularly preferably from 5 to 10 wt.%. If the mixed amount of the coloring matter is too small, the effect of resistance to secondary adhesion can be difficult to feel.

Mix the amount of pearlescent agent is preferably less than 5 wt.%. If it is too large, the ability to spreading may be weak.

In cosmetic tool for lip according to the present invention, besides the above components, you can mix the ingredients usually used in cosmetics for lips (for example, oil, is different from the above oils, powder, polymeric compound, a humectant, an aromatic substance, an antioxidant, a preservative and a decorative component), if it does not have a negative impact on the effect of the present invention.

Examples of humectants include polyol as one humectants, such as propylene glycol and 1,3-butyleneglycol.

In the present invention, the stability is improved as a result of the efficient when blended what I volatile silicone oil and water and/or glycerin.

As such, the volatile silicone oil is not limited, but preferred decamethylcyclopentasiloxane. Mix the amount of volatile silicone oil is preferably from 3 to 15 wt.% relative to the overall number of cosmetic products. If the mixed amount of the volatile silicone oil is too small, the stability may be weak. If it is too high, the humidity may be lost.

Mix the amount of water and/or glycerin is preferably from 3 to 12 wt.% relative to the overall number of cosmetic products, and particularly preferably from 5 to 9 wt.%. If the mixed amount of water and/or glycerol is too small, the stability may be weak. If it is too large, the dispersibility of the coloring agent may be weak. Of these components, only the glycerol can be mixed without water. Thus, the content of glycerin is preferably from 25 to 100 wt.%, and more preferably from 25 to 75 wt.% in water and/or glycerin.

However, in the present invention when definitiondefinition mix as methylphenylsiloxane (b), preferably, volatile oil, water and glycerol did not mix. In this case, "not mixed" means that the mixture is not added anything except random contaminants, such as PR is MESI.

Thus, when mixing definitiondefinition can be obtained cosmetic for lips with excellent stability without mixing volatile oil component, water and glycerin. In the event of such cosmetics lip placement in a tightly closed container (the container, which can prevent the evaporation of volatile component) is not necessary; thus, the advantage consists in the fact that the restriction of the container.

Preferably, the cosmetic lip according to the present invention has been made in such a way that the separation did not occur throughout the entire manufacturing process, and maintained the status of one homogeneous phase.

Cosmetic lip of the present invention can be used for lipsticks, lip gloss, foundations to lipsticks, coatings for lipsticks, creams, lip gloss, and the like. In particular, the preferred solid lipstick.

EXAMPLES

Further, the present invention is described in the following examples. However, the invention is not limited to these examples. Unless otherwise stated, the amount of each component in the mixture is expressed in wt.%.

Before illustrating examples explained in the methods of assessment used in the present invention.

Evaluation (1): On enony test the effect of resistance to secondary adhesion

Test for suitability for use in real conditions was conducted 10 professional members of the Commission for quality assessment. Five sensory evaluation (points) effect of resistance to secondary adhesion after application to the lips was based on the following evaluation criteria. The determination was carried out according to the average scores based on the following evaluation criteria.

(Point)

5 points: excellent

4 points: excellent

3 points: normal

2 points: bad

1 point: very bad

(Evaluation criteria)

S: the Average score is 4.5 points or higher and less than 5 points.

A*: the Average score is 4 points or higher and less than 4.5 points.

A: the Average score is 3.3 points or higher and less than 4 points.

B: the Average score of 2.5 points or higher and less than 3.3 points.

C: the Average score is 1 point or higher and less than 2.5 points.

The examples provided with the sign "-" in the table, had poor stability, and the effect of resistance to secondary adhesion could not be measured.

Evaluation (2): Evaluation of the stability test sample (the total mass of material)

The stability of the material obtained by providing 100 g of the sample, which was prepared by heating to 90°C and mixing to cool at room temperature (25°C), was estimated based on the following criteria OC the NCI.

(Evaluation criteria)

A: uniform and undivided

From: heterogeneous and divided

Evaluation (3): Evaluation of the stability test sample (after molding) Wax uniformity in the plane of the slice of the sample in the form of a pencil was evaluated on the basis of the following evaluation criteria.

(Evaluation criteria)

A*: uniform

A: slightly inhomogeneous

In: multiple heterogeneous

From: heterogeneous

Evaluation (4): assessment of the appearance of the sample (the total mass of material)

The appearance of the material obtained by providing 100 g of the sample, which was prepared by heating to 90°C and mixing to cool at room temperature (25°C), was estimated based on the following evaluation criteria.

(Evaluation criteria)

A: there is No aggregation of the coloring matter, and it is homogeneous.

*: There is a small aggregation of coloring matter.

Q: Is the aggregation of the coloring matter.

From: Rich aggregation of coloring matter, and it is inhomogeneous.

Evaluation (5): Assessment of ability to spreading

Test for suitability for use in real conditions was conducted 10 professional members of the Commission for quality assessment. Five sensory evaluation (points) ability to flow after application to the lips was based on the following criteria assessment is key. The determination was carried out according to the average scores based on the following evaluation criteria.

(Point)

5 points: excellent

4 points: excellent

3 points: normal

2 points: bad

1 point: very bad

(Evaluation criteria)

S: the Average score is 4.5 points or higher and less than 5 points.

A*: the Average score is 4 points or higher and less than 4.5 points.

A: the Average score is 3.3 points or higher and less than 4 points.

In: GPA of 2.5 points or higher and less than 3.3 points.

With: the Average score is 1 point or higher and less than 2.5 points.

First samples (solid lipsticks) mixed compositions shown in tables 1 and 2 were obtained in the usual way. The respective samples were evaluated for assessment of (1) and (2) on the basis of the above evaluation criteria. The result is presented in tables 1 and 2.

All methylphenylsiloxane used in the following Examples and Comparative Examples were those who separated when mixed with hydrogenated polyisobutene at 25°C.

1: Deodorized polybutene R (manufactured by the company NIKKO RICA CORPORATION)

2: Silicone KF54 (viscosity: 400 mm2/s, manufactured by the company Shin-Etsu Chemical Co., Ltd.)

3: Methylphenylimino the FZ3156 (viscosity: 165 mm 2/s, manufactured by the company Dow Corning Toray Co., Ltd.)

4: Silicone KF56 (viscosity: 14 mm2/s, manufactured by the company Shin-Etsu Chemical Co., Ltd.)

5: ESTEMOL 182V (manufactured by the firm of The Nisshin OilliO Group, Ltd.) 6: WOGEL-18DV (manufactured by the company MATSUMOTO TRADING Co., Ltd.)

7: ABIL EM90 (manufactured by the company Evonik Degussa Japan Co., Ltd.)

8: Nikkol PMS-SEN (manufactured by the company Nikko Chemicals Co., Ltd.)

9: SC0928SL (manufactured by the company Shin-Etsu Chemical Co., Ltd.)

10: Nomcort HKG (manufactured by the firm of The Nisshin OilliO Group, Ltd.)

11: the Sample was solid.

In accordance with table 1, the sample of Comparative Example 1, were mixed hydrogenated polyisobutene and various methylphenylsiloxane, had a great effect resistance to secondary adhesion, but the stability was weak.

The samples of Examples 1-4, where part of the hydrogenated polyisobutene in Comparative Example 1 was replaced with a surfactant, such as sorbitan sesquiisostearate, diglycidylethers, cetyl-PEG/BCP-10/1 Dimethicone or the propylene glycol monostearate, had a great effect resistance to secondary adhesion, and stability of the sample with total mass of the material was also excellent.

The sample of Example 5, where the mixing amount of each component in Example 1 was varied, also had a great effect resistance to secondary adhesion and stability.

The sample of Example 6, where part of hydrogen the new of polyisobutene in Example 5 was replaced with mineral oil, also had a great effect resistance to secondary adhesion and stability.

On the other hand, in accordance with table 2, the samples of Comparative Examples 2-9, where part of the hydrogenated polyisobutene in Comparative Example 1 was replaced with a surfactant such as lauryl PEG-9 polydimethylsiloxyethyl, glycerinated/eicosanoate, sorbitan laurate, sorbitan isostearate or PEG-derivative of hydrogenated castor oil, had a weak effect of resistance to secondary adhesion or stability.

Then the authors present invention investigated the properties of various mixed surfactants in table 1 and table 2. Thus, appropriate surfactants and hydrogenated polyisobutene or trimethylenetrinitramine used in the ratio (surfactant : hydrogenated polyisobutene or trimethylenetrinitramine = 1:1 (mass ratio)) was mixed at 90°C. After the mixture was allowed to stand for 15 minutes, watched the state of the mixture. Evaluation criteria below. The result is shown in table 3.

(Evaluation criteria)

And*transparent and single-phase

A: cloudy and single-phase

With: split

PEG-40 hydrogenated castor oil
Table 3
Hydrogenated polyisobutene No. 1Trimethylpentene trisiloxane
Sorbitan sesquiisostearate No. 5And*And*
Diglycidylethers No. 6And*And
Cetyl-PEG/BCP-10/1 Dimethicone No. 7AndAnd*
Of the propylene glycol monostearate No. 8And*And*
Lauryl-PEG-9 polydimethylsiloxyethyl Dimethicone No. 9
Sorbitan isostearate
PEG-10 Dimethicone
PEG-10 hydrogenated castor oilAnd*
PEG-30 hydrogenated castor oilAnd*
PEG-100 hydrogenated castor oilAnd*

In accordance with table 3 of lipophilic surfactants used in table 1 and mixed in cosmetic tool for lips, had a great effect resistance to secondary adhesion, and stability studies of the total mass of the material was not separated when mixed with hydrogenated polyisobutene and methylphenylsiloxane at high temperature, these surfactants were highly compatible. On the other hand, lipophilic surfactants used in table 2, were separated when mixed with hydrogenated polyisobutene and/or methylphenylsiloxane at high temperatures.

Accordingly, in cosmetic tool for lip according to the present invention containing (a) hydrogenated polyisobutene, (b) methylphenylsiloxane(s) and (d) a wax, it is necessary to have satisfied the condition that mix lipophilic surfactant (not separated as when mixed with component (a), and when mixed with component (b) at 90°C.

Then the authors present invention investigated the mixed amount of hydrogenated poly is isobutene (a). The result is presented in table 4.

Table 4
CfAtAtAtAtAtCf
sorymeasuresmeasuresmeasuresmeasuresmeasuressory
Example718910Example
1011
(a)Hydrogenated polyisobutene No. 15101520253035
(b)Diphenylmethan No. 224191494--
Trimethylenetrinitramine No. 340404040403934
Definitiondefinition No. 49999 999
(C)Sorbitan sesquiisostearate No. 54444444
(d)Polyethylene wax7777777
Dye, pearlescent agent11111111111111
Evaluation (1): Effect of resistance to secondary adhesionAndAnd*And*And*And
Evaluation(2): Stability of the sample (the total mass of material)AndAndAndAndAndAndAnd

In accordance with table 4 in the sample of Comparative Example 10, where the mixed amount of hydrogenated polyisobutene was too small, the effect of resistance to secondary adhesion was weak.

In the sample of Comparative Example 11 where the mixed amount of hydrogenated polyisobutene was too large, the effect of resistance to secondary adhesion was weak.

Accordingly, it is necessary to mix the amount of hydrogenated polyisobutene (a) in the mixture according to the present invention ranged from 10 to 30 wt.%.

Then the authors present invention investigated the mixed amount of definitiondefinition in methylphenylsiloxane (b). The result is presented in table 5. The following table 5 mix quantities are given in parts by weight.

Table 5
AtAtAtCf
sorymeasuresmeasuresmeasuressory
Example11121Example
1213
(a)Hydrogenated polyisobutene No. 11515151515
(b)Diphenylmethan No. 21414141414
Trimethylenetrinitramine No. 3 4040404040
Definitiondefinition No. 4-36920
(C)Sorbitan sesquiisostearate No. 544444
(d)Polyethylene wax77777
Dye, pearlescent agent1111111111
Only919497100111
Evaluation (1): Effect ustoichivosti secondary adhesion And*And*And*And*
Evaluation (2): Stability of the sample (the total mass of material)InInAndAnd

According to table 5, in Comparative Example 12, where definitiondefinition not mixed, the effect of resistance to secondary adhesion was excellent, but the stability of the sample with total mass of the material was weak.

With increasing mixed number of definitiondefinition stability of the sample was improved (Examples 11, 12 and 1). However, in Comparative Example 13, where the mixed amount of definitiondefinition was great, the effect of resistance to secondary adhesion was weak, although the stability was excellent.

Accordingly, it is preferable that definitiondefinition mixed as the component (b) cosmetics lip of the present invention, and its mixed number ranged from 1 to 17 wt.% relative to the overall number of cosmetic products.

Then the authors present invention studies the Ali other components mixed in the sample, where definitiondefinition not mixed in the component (b). The result is shown in table 6.

Table 6
CfAtAtAtAt
sorymeasuresmeasuresmeasuresmeasures
Example13141516
14
(a)Hydrogenated polyisobutene No. 11515101010
(b) Diphenylmethan No. 239192618-
Trimethylenetrinitramine No. 33030263452
Definitiondefinition No. 4-----
(C)Diglycidylethers No. 644444
(d)Polyethylene wax is a microcrystalline wax No. 1277999
Dye, pearlescent agent6655
Decamethylcyclopentasiloxane-13121212
Ion-exchange water-2444
Glycerin-5444
Evaluation (1): Effect of resistance to secondary adhesion-And*And*And*And*
Evaluation (2): Stability of the sample (the total mass of material)AndAndAndAnd
Evaluation (3): Stabil the activity of the sample (after molding) AndAndAndAnd

No. 12: RA wax (manufactured by the company NIKKO RICA CORPORATION)

In accordance with table 6 stability was very poor in Comparative Example 14, where definitiondefinition not mixed in the component (b), as in the case of Comparative Example 12.

However, the sample of Example 13, where the volatile oil component, water and glycerin were mixed instead of the component (b) of Comparative Example 14 had a great effect resistance to secondary adhesion, and not only the stability of the bulk material, but also stability after molding was excellent.

The samples of Examples 14-16, where the mixed amount of hydrogenated polyisobutene reduced, and the blend quantity of the component (b), respectively varied, also had a great effect resistance to secondary adhesion, and they were also stable.

Accordingly, it was found that stability cannot be improved by mixing the volatile oil component, water and glycerine, even when definitiondefinition were not contained in methylphenylsiloxane (b), which should be mixed in the present invention.

Then the authors present invention investigated the pre is respectful mix the amount of water and/or glycerol in the case of mixing water and/or glycerin. The result is presented in table 7.

Table 7
AtAtAtCfCf
measuresmeasuresmeasuressorysory
141718ExampleExample
1516
(a)Hydrogenated polyisobutene No. 11010101010
(b)Diphenylmethan No. 226 27282930
Trimethylenetrinitramine No. 32627282930
(C)Diglycidylethers No. 644444
(d)Polyethylene wax is a microcrystalline wax No. 1299999
Dye, pearlescent agent55555
Decamethylcyclopentasiloxane1212121212
Ion-exchange water 4321-
Glycerin4321-
Evaluation (1): Effect of resistance to secondary adhesionAnd*And*And*--
Evaluation (3): Stability of the sample (after molding)AndIn*In*

In accordance with table 7 in Example 14, where the mixed amount of water and glycerol were great as the effect of resistance to secondary adhesion, and stability were excellent.

However, when the mixed amount of water and glycerol were reduced, this had an impact on stability. In Comparative Examples 15 and 16, where the amount of mixed quantities of water and glycerol was 2 wt.% or less, the stability was weak.

Accordingly, it is preferable to mix to the icesta water and glycerin mix in cosmetic tool for lip according to the present invention, ranged from 3 to 12 wt.%.

Then the authors present invention investigated the percentage of water and/or glycerin, mixed in the present invention. The result is presented in table 8.

Table 8
ExampleExampleExampleExampleExample
1920142122
(a)Hydrogenated polyisobutene No. 11010101010
(b)Diphenylmethan No. 22626262626
Trimethylpentene disiloxane No. 3 2626262626
(C)Diglycidylethers No. 644444
(d)Polyethylene wax is a microcrystalline wax No. 1299999
Dye, pearlescent agent55555
Decamethylcyclopentasiloxane1212121212
Ion-exchange water8642-
Glycerin-2468
Evaluation (1): Effect of resistance to secondary adhesionAnd*And*And*SS
Evaluation (3): Stability of the sample (after molding)AndAndAndAndIn*

In accordance with table 8 samples with excellent resilience to the secondary adhesion were obtained by increasing the percentage of glycerol. However, it was found that stability becomes weak when the water don't mix.

Accordingly, when water and/or glycerin are mixed in the present invention, the percentage content of glycerin is preferably from 25 to 100 wt.%, and particularly preferably from 25 to 75 wt.%.

Then the authors present invention investigated the kinds of the coloring matter mixed in the present invention. The result is shown in table 9.

td align="justify"> And
Table 9
DoughDoughDoughDoughDoughDoughDough
newnewnewnewnewnewnew
AtAtAtAtAtAtAt
measuresmeasuresmeasuresmeasuresmeasuresmeasuresmeasures
124567
(a)Hydrogenated polyisobutene15151515151515
(b)Diphenylmethan18.518.522.514.514.520.520.5
Trimethylpent35353535353535
ventriculogram
Diphenylsilane9999999
fenitrothion No. 4
(C)Sorbitan sesquiisostearate2.52.52.52.52.52.52.5
Diglycidylethers2222222
(d)Polyethylene wax7 777777
Dye99513955
Such mica2------
Such mica treated with Dimethicone-2226--
Such mica coated with red iron oxide---- -4-
Such mica treated with Dimethicone, covered with red iron oxide------4
Evaluation (1): Effect of resistance to secondary adhesionAnd*And*And*And*And*And*And*
Evaluation (4): the appearance of the sample (bulk material)In*AndAndAndAndIn*And
Evaluation (5): the Ability to spreadingAndAnd*SInAndAnd*

The sample of Test Example 1, where the components (a)to(d) were appropriately mixed, and the pigment and pearlescent agent (titanium containing mica) was used as the coloring matter, had a great effect resistance to secondary adhesion; however, watched some aggregation of the coloring matter.

The sample of Test Example 2, where the pearlescent agent in Test Example 1 was replaced with a pearlescent agent, treated with silicone, possessed not only an excellent effect of resistance to secondary adhesion, but also had excellent appearance and ability to flow.

These trends were the same as pearlescent agent used titanium containing mica coated with red iron oxide instead of titanium containing mica (Sample 6 and Sample 7).

For the Test Examples 2-5 was found that the ability of spreading varies depending on the kind of the coloring matter and its mixed number.

On the basis of the above when the pearlescent agent is mixed as the coloring matter cosmetics lip of the present invention, it is preferable to use pearlescent agent, examined the silicone, and its mixing amount is preferably less than 5 wt.% from the point of view of ability to flow.

Because pearlescent agent, treated silicone that usually moves in methylphenylsiloxane (b) in the retrieval process, believe that it is better not to mix it in the system of the present invention from the viewpoint of the effect of resistance to secondary adhesion.

However, when the pearlescent agent having a high aspect ratio, to be applied on the lips, pearlescent agent usually moves in hydrogenated polyisobutene (a) in contact during application. Consequently, through the use of pearlescent agent, treated with silicone, can be obtained a homogeneous tool for the lips, which is easily dispersible in the process of obtaining, without affecting the effect of resistance to secondary adhesion during application.

In the future, lipstick 1 of Example 2 described in the above table 1, and lipstick 2, where mixed volatile oil component of the following composition, and which had the effect of resistance to secondary adhesion, inflicted on hand five times, respectively. Immediately after the application has pressed the Cup and took a picture of the Cup, as shown in figure 1.

In accordance with figure 1, it was found that lipstick 1 according to the present invention had about the personal effect of resistance to secondary adhesion since immediately after application.

Composition (lipstick 2)

(Silicone oil)

The copolymer (perferential/diphenylmethan)23 wt.%
Trimethylenetrinitramine3
Stearothermophilus2
PEG-10 Dimethicone4.5
PEG/BCP-19/19 Dimethicone3

(Film-forming agent)

The copolymer (acrylate/propyltrimethylammonium)27

(Volatile oil)

Cyclopentasiloxaneof 17.5

(Fixing agent)

Ceresin6
Candelilla wax3

(Other)

Dye, pearlescent agent11

Hereinafter in this application p is illyustrirovany compositions of Examples and other Comparative Examples cosmetics lip of the present invention. It is clear that the present invention is not limited to these compositions of Examples and defined by the scope of the claims.

In addition, all methylphenylsiloxane (b)used in the following compositions of Examples 1-14 were separated when mixed with hydrogenated polyisobutene (a) at 25°C.

Table 10
CompoCompoCompoCompoCf
positionpositionpositionpositionsory
ExampleExampleExampleExampleExample
123417
(a)Gidrogenit the integration of polyisobutene No. 1 1515151515
(b)Diphenylmethan No. 212171411-
Trimethylenetrinitramine No. 33030303030
Definitiondefinition No. 4-36920
(C)Diglycidylethers No. 644444
(d)Polyethylene wax is a microcrystalline wax No. 1277777
Dye66666
Decamethylcyclopentasiloxane12,98to 4.98to 4.98to 4.98to 4.98
Ion-exchange water22222
Glycerin55555
Dipropyleneglycol11111
The copolymer
(alkylacrylate/Dimethicone) No. 13
55555
Antifoam0,020,02 0,020,020,02
Evaluation (1): Effect
resistance to secondary adhesion
And*And*And*And*
Evaluation (3): Stability of the sample(after molding)AndAndAndAndAnd

No. 12: Silicone KR (manufactured by the company Shin-Etsu Chemical Co., Ltd.)

Components (b) of Comparative Example 17 do not separate when mixed with (a) at 25°C.

Table 11
The composition of Example 5The composition of Example 6The composition of Example 7
(a)Hydrogenated polyisobutene No. 1101520
(b)Diphenylmethan No. 2 383328
Trimethylenetrinitramine No. 3202020
(C)Diglycidylethers No. 6444
(a)Polyethylene wax is a microcrystalline wax No. 12777
Dye555
Decamethylcyclopentasiloxane121212
Glycerin444
Evaluation (1): Effect of resistance to secondary adhesionAnd*And*And*

The composition of Example 5, where the mixed number is the primary objective hydrogenated polyisobutene was 10 wt.%, the ability to spreading and stability were excellent. The composition of Example 7, where the mixed amount of hydrogenated polyisobutene was 20 wt.%, color output was excellent.

Table 12
CfCfCfCompoCompo
sorysorysorypositionposition
ExampleExampleExampleExampleExample
18192089
(a)Hydrogenated polyisobutene No. 1 2020101010
Diphenylmethan No. 22736263438
(b)Definitiondefinition No. 42718261814
(C)Diglycidylethers No. 6--444
(d)Polyethylene wax is a microcrystalline wax No. 1299999
Dye55 555
Decamethylcyclopentasiloxane1212121212
Ion-exchange water--444
Glycerin--444
Evaluation (1): Effect of resistance to secondary adhesion-And*And*

Components (b) of Comparative Example 20 was not separate when mixed with (a) at 25°C.

Table 13
Comp the position of the Sample 10 The composition of Example 11The composition of Example 12
(a)Hydrogenated polyisobutene No. 1121110
(b)Diphenylmethan No. 2282828
Trimethylenetrinitramine No. 3282828
(C)Diglycidylethers No. 6234
(d)Polyethylene wax is a microcrystalline wax No. 12999
Dye555
Decamethylcyclopentasiloxane1212Ion-exchange water222
Glycerin222
Evaluation (1): Effect of resistance to secondary adhesionAnd*And*And*

The composition of Example 12, where the mixed amount of digitaldisaster (C) was more than 4 wt.%, stability was particularly good.

The composition of Example 13: Solid lipstick

Hydrogenated polyisobutene

(average molecular weight: 1000)15 wt.%
Trimethylenetrinitramine40
Diphenylmethan23
Definitiondefinition9
Sorbitan sesquiisostearate4
Iron oxide red1
Lithol Rubin ICA (BaS04)1
Polyethylene wax6
Microcrystalline wax1

(Production method)

After heating and dissolving solid lipstick was prepared by mixing and dispersing.

The composition of Example 14: Solid lipstick

Hydrogenated polyisobutene

(average molecular weight: 1000)15 wt.%
Trimethylenetrinitramine54
Sorbitan sesquiisostearate4
Definitiondefinition9
Polyethylene wax7
Dye, pearlescent agent11

(Production method)

After heating and dissolving solid lipstick was prepared by mixing and dispersing.

DESCRIPTION DIGITAL SIGNS

1: lipstick of Example 2

2: Composition of lipstick (lipstick 2)

1. Cosmetic environments the creation lip, contains the components (a)to(d):
(a) from 10 to 30 wt.% hydrogenated polyisobutene;
(b) from 30 to 70 wt.% one or more kinds of methylphenylsiloxane who separate when mixed with (a) at 25°C., selected from trimethylenetrinitramine, definitiondefinition, diphenylmethane and penultimately, while containing trimethylenetrinitramine;
(c) from 0.5 to 8 wt.% one or more lipophilic surfactants, which are not separated as when mixed with component (a), and when mixed with component (b) at 90°C, selected from sorbitan of sesquiisostearate, of propylene glycol monostearate, cetyl-PEG/BCP-10/1 dimetikona and digitaldisaster; and
(d) from 5 to 12 wt.% the wax.

2. Cosmetic lip according to claim 1, additionally containing a coloring matter.

3. Cosmetic lip according to claim 2, where the dye is a pearlescent agent, treated silicone.

4. Cosmetic lip according to claim 1, where the mass ratio of component (b) to component (a) is component (b)/component (a)=1.1 to 6.

5. Cosmetic lip according to claim 1, where component (b) contains definitiondefinition.

6. Cosmetic lip according to claim 5, where the mixed amount of definitiondefinition is from 1 to 17 wt.% relative to the General to whom icesta cosmetics.

7. Cosmetic lip according to claim 1, additionally containing a volatile silicone oil and water and/or glycerin.

8. Cosmetic lip according to claim 5, in which there is no volatile oil component.

9. Cosmetic product for the lips, containing the components (a)to(d) and does not contain volatile oil components:
(a) from 10 to 30 wt.% hydrogenated polyisobutene;
(b) from 30 to 70 wt.% more than two kinds of methylphenylsiloxane who separate when mixed with (a) at 25°C., selected from trimethylenetrinitramine, definitiondefinition, diphenylmethane and penultimately, while containing trimethylenetrinitramine, and the content of definitiondefinition is from 1 to 17 wt.% relative to the overall number of cosmetic products;
(c) from 0.5 to 8 wt.% one or more lipophilic surfactants, which are not separated as when mixed with component (a), and when mixed with component (b) at 90°C, selected from sorbitan of sesquiisostearate, of propylene glycol monostearate, cetyl-PEG/BCP-10/1 dimetikona and digitaldisaster; and
(d) from 5 to 12 wt.% the wax.

10. Cosmetic product for the lips, containing the components (a)to(d):
(a) from 10 to 25 wt.% hydrogenated polyisobutene;
(b) from 30 to 65 wt.% one or more kinds of methylphenylsiloxane, which is s separate when mixed with (a) at 25°C, selected from trimethylenetrinitramine, definitiondefinition, diphenylmethane and penultimately, while containing trimethylenetrinitramine;
(c) from 2 to 7 wt.% digitaldisaster; and
(d) from 5 to 12 wt.% wax;
from 3 to 15 wt.% volatile silicone oil and from 3 to 12 wt.% water and/or glycerin.



 

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2 cl, 6 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to an agent for improving antibacterial action, containing an active ingredient in the form of a fraction of molecular weight 5000 or less, prepared of kombu (seaweed) extract.

EFFECT: what is disclosed is a method of using a combination of the agent for improving antibacterial action, lactoperoxidase, glucose oxidase and glucose as an antibacterial composition, having strong antibacterial action, and a food product or beverage containing the antibacterial composition.

10 cl, 7 ex, 4 tbl

FIELD: medicine, oncology, amino acids.

SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.

EFFECT: valuable medicinal antitumor properties of preparation.

8 cl, 4 tbl, 2 dwg, 4 ex

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