Method of producing highly purified disinfectant
SUBSTANCE: described is a method of producing a highly purified disinfectant which contains polyhexamethylene guanidine hydrochloride, characterised by that flush water from production of polyhexamethylene guanidine hydrochloride in solid form is used. The flush water is mixed with 25% NaCl solution in ratio of 1:1 (polyhexamethylene guanidine hydrochloride solution with impurities: NaCl solution) while stirring constantly for 1 hour at temperature in the range of 50-60°C. Stirring is stopped and the mixture is cooled to 5°C, thereby dividing the mixture into two parts; the bottom part is drained, neutralised and sent for recycling and the top part containing up to 60-70% polyhexamethylene guanidine hydrochloride is further diluted to 50% with an aqueous solution of quaternary ammonium salts (QAS) to QAS concentration of not higher than 5%.
EFFECT: extracting highly purified, concentrated high-molecular weight polyhexamethylene guanidine hydrochloride from flush water, reducing the amount and toxicity of waste water, improving disinfecting properties and increasing output of the commercial-grade product when producing polyhexamethylene guanidine hydrochloride in solid form, reducing cost.
1 cl, 1 ex, 2 tbl
The proposed method relates to the field of polymeric organic chemistry, in particular to a method for producing high-purity disinfectant that can be used as an effective disinfectant, used in medicine, veterinary medicine, sewage treatment, and in industries where the use of biocidal products.
A method of obtaining a disinfectant (see the description of the author's certificate of the Russian Federation No. 1616898, IPC C07C 279/00, A61L 2/16, publ. 30.12.1990).
The known method is based on the polycondensation of a diamine (HMDA) and guanidine hydrochloride (HGH), resulting in a receive end - product disinfectant - polyhexamethylene guanidine hydrochloride (phmg-GC) in solid form. The polycondensation is performed by heating and uniform introduction of the melt, HMDA in the melt HGH in the ratio 1:(0,85-0,95) for 2.5 h, the mixture is heated to a temperature of 180°C, and after the introduction of GMDA the temperature was raised to 240°C and maintain it for 5 hours
After discharge of each batch of finished product equipment should be washed and the wash water is drained. Wash water partially contain pgmg-GC, resulting in the contamination of the environment.
Obtained in a known manner pgmg-GC has a small bacteriol the political activity and high toxicity due to contamination of its HMDA, which is the toxic substance of the second class of danger.
A method of obtaining a disinfectant, adopted as a prototype (see the description of the invention to the patent of Russian Federation №2165268, IPC A61L 2/16, C08G 73/00, publ. 20.04.2001).
The known method is based on polycondensation of HMDA and HGH. In the known method previously get HGH by reacting ammonium chloride with dicyandiamide when heated. The polycondensation of the salt of guanidine with HMDA carried out by heating in three stages, by heating this reaction mass in the first stage to a temperature not higher than 130°C, the second to a temperature not above 150°C, and the third to a temperature not higher than 180°C, the saponification reaction is carried out at a temperature not exceeding 60°C, and washing the Foundation carried out with a solution of chloride of an alkali metal, giving the base of the acid, and then allocate pgmg-GC in solid form.
In the known method requires multiple rinsing of the equipment, leading to the formation of large amounts of flush water flowing into the waste water polluting the environment, which is the main disadvantage of this method. Wastewater contain the product pgmg-GC, and impurities such as the unreacted HMDA, which vysokoletuchie and toxic, low molecular weight oligomers, polymerge the Chelyabinsk, which are less toxic, but degrades the quality of the finished product.
Get pgmg-GH is an effective polymeric biocide against wide spectrum of gram-positive and gram-negative bacteria do not form toxic products in the water, not inactivated protein, is easily decomposed by enzyme systems of the person, but does not destroy bacteria with hydrophobic lipid wax shell.
The technical objective of the proposed method is the extraction of highly purified, concentrated pgmg-GC high molecular weight (about 20 000) of wash water, reducing the amount and toxicity of waste water, the improvement disinfectant properties and increase the yield of marketable products in the production pgmg-GC in solid form, reducing the cost.
The technical problem is solved in that in the method of obtaining high-purity disinfectant containing polyhexamethylene guanidine hydrochloride, used wash water from the production of polyhexamethylene guanidine hydrochloride in solid form, which is collected, then mixed with 25%NaCl solution at a ratio of 1:1 (solution of guanidine hydrochloride with impurities:NaCl solution) under stirring for 1 hour at a temperature in the range of 50-60°C, and then the stirring is stopped, Hledat to a temperature of 5°C, thereby making the separation into two parts, the lower part of the waste is neutralized and sent for recycling, and the upper part containing up to 60-70% polyhexamethylene guanidine hydrochloride, optionally diluted with 50% aqueous solution HOUR to HOUR concentration not higher than 5%.
The proposed method allows to:
to get to production of the disinfectant highly purified solution of polyhexamethylene guanidine hydrochloride high concentrations;
- reduce the amount and toxicity of wastewaters;
- to increase output per unit of raw material in the production of polyhexamethylene guanidine hydrochloride in solid form;
to ensure the ability of the disinfectant on the basis of polyhexamethylene guanidine hydrochloride to destroy a wide spectrum of gram-positive and gram-negative bacteria as well as bacteria with hydrophobic lipid wax shell.
The inventive method consists of isolating highly purified, concentrated pgmg-GC of flushing water, polecamy in the production pgmg-GC in solid form. Wash water is used repeatedly, as a result they accumulate pgmg-GC. After saturation of the wash water pgmg-H.H. the washing quality is deteriorating, the wash water is fed into the apparatus, and for washing equipment serves a portion of fresh water.
AP is Arat equipped with a stirrer, jacket heating / cooling and bottom discharge with dividing lantern. In the apparatus gradually add 25%NaCl solution with constant stirring for 1 hour. The temperature in the apparatus is maintained within the range of 50-60°C with a sharp pair. Then stop stirring and shirt apparatus serves the coolant from brine installation with a temperature of 5°C. When cooling is delamination of the contents of the device into two parts. The top layer contains high-purity aqueous solution pgmg-GC for the production of a disinfectant, in which there are no low molecular weight oligomers and free amines, which become the bottom layer of NaCl solution.
The bottom layer is separated using a separating lantern, neutralized with 1%HCl solution to pH 5-6 and sent for recycling. A purified solution pgmg-GC upper layer was diluted to 50% (commercial product) in an aqueous solution of H (Quaternary ammonium salts), for example, CATPAW CAS No. 61798-71-7 or KATHHOJ CAS No. 85736-63-6. Diluted so that the total number of HOURS in the solution did not exceed 5%.
Wash water received 10 cycles of washing equipment in the production pgmg-GC in solid form consisting of water and 3000 kg and KZT 446.4 kg impurities in the number 3446,4 kg fed into the apparatus, equipped with a stirrer, jacket heating of the-cooling and bottom discharge with dividing lantern and then gradually add 25%solution of NaCl at a ratio of 1:1 by weight (solution pgmg-GC with impurities:NaCl) with constant stirring for 1 hour. The temperature in the apparatus is maintained within the range of 50-60°C with a sharp pair. Then stop stirring and shirt apparatus serves the coolant from brine installation with a temperature of 5°C. When cooling is delamination of the contents of the device into two parts. The top layer contains high-purity aqueous solution pgmg-GC for the production of a disinfectant, in which there are no low molecular weight oligomers and free amines, which become the bottom layer of NaCl solution.
The bottom layer is separated using a separating lantern, neutralized with 1%HCl solution to pH 5-6 and sent for recycling.
Next, measure the concentration of a purified solution pgmg-GC upper layer, which may be 60-70%.
Depending on the results of measurement of the top layer in the device is again heated to 50-60°C and further diluted with up to 50% (commercial product) in an aqueous solution of H (Quaternary ammonium salts), CATPAW CAS No. 61798-71-7. Diluted so that the total number of HOURS in the solution did not exceed 5%, necessary for the destruction of disinfectant bacteria with hydrophobic lipid wax shell.
Was the analysis of the composition of the layers, which are shown in table 1.
|pH||Commodity pgmg-GC||Total impurities, including NaCl||Water||Total|
|The top layer||7.9||69,90||0,05||30,05||100,00|
|The bottom layer||6.8||0,00||14,96||85,04||100,00|
As can be seen from table 1, managed to get 352,1 kg macromolecular pgmg-GC (calculated on the dry product) of highly purified (>99%) and concentrate the solution up to 69.9%. It is possible to increase the yield of marketable product per unit of raw material by 4.7%.
The remaining bottom layer with a pH of 6.8 in the number 6389,16 kg transfer for recycling, representing 21% of the same amount of wastewater. A large part of the pollution goes into neutral compounds do not pose a great threat to the environment.
Analysis of the composition of the wash water at a pH of 10.5 are shown in table 2.
|HGH||HMDA||Oligomers and low molecular weight polymer homologues||ovary pgmg-GC||Uncertain to 100%||Water||Total|
|kg||45,32||the ceiling of 5.60||27,52||360,10||of 7.90||3000,00||3446,44|
The method of obtaining high-purity disinfectant containing polyhexamethylene guanidine hydrochloride, characterized in that the used wash water from the production of polyhexamethylene guanidine hydrochloride in solid form, which is collected, then mixed with 25%NaCl solution at a ratio of 1:1 (solution of guanidine hydrochloride with impurities: NaCl solution) under stirring for 1 hour at a temperature in the range of 50-60°C, then stop stirring, cooled to a temperature of 5°C, thereby making the separation into two parts, the lower part of the waste is neutralized and sent for recycling, and the upper the part containing up to 60-70% of polyhexamethyl the guanidine hydrochloride, further diluted with 50% aqueous solution of H (Quaternary ammonium salts) to the concentration of the HOUR of not more than 5%.
SUBSTANCE: method of producing a disinfectant involves first carrying out polycondensation of hexamethylenediamine and guanidine hydrochloride. Polycondensation starts with preparation of a reaction mass in form of a suspension of crystalline guanidine hydrochloride in molten hexamethylenediamine, taken in ratio of 1:(1-1.5). The suspension is obtained by gradually adding crystalline guanidine hydrochloride, preheated to temperature of 90-120°C, to molten hexamethylenediamine and then stirring. The reaction mass is then heated in steps: holding for 4 hours at 120°C, then for 8 hours at 160°C and then for 3 hours at 180°C. Temperature is then gradually raised to 210°C at a rate of 3-4°C/h. The reaction mass is then subjected to vacuum treatment and cooled.
EFFECT: method enables to reduce toxicity of the end product and obtain a polymer with the required molecular weight and sufficient purity without washing steps.
SUBSTANCE: described is a method of producing polyguanidines by polycondensation of a guanidine salt with a diamine while heating, characterised by that polycondensation is carried out in the presence of an organic acid or a mixture of organic acids and heating is carried out in steps as follows: at the first step at 120-130°C for 0.5-1 hour; at the second step at 150-160°C for 3.5-4 hours; at the third step at 170-180°C for 0.5-1.5 hours.
EFFECT: improved method.
11 cl, 2 tbl, 4 ex
SUBSTANCE: present invention relates to polyphenylene ether ketone oximates, as well as a method for production thereof. An elementary unit of said polyphenylene ether ketone oximate has the formula: [-O-N=C(CH3)-C6H4-O-C6H4-C(CH3)=N-O-C6H4-CO-C6H4]n. The polyphenylene ether ketone oximate has reduced viscosity of 0.4-0.5 dl/g and molecular weight ranging from 40800 to 51000. Polyphenylene ether ketone oximate are obtained by non-equilibrium nucleophilic polycondensation of difluorodiphenyl ketone with diacetyl diphenyl oxide diketoxime. The reaction is carried out in dimethyl sulphoxide for 6 hours at 165°C, with reaction of equimolar amounts of potassium diacetyl diphenyl oxide dioximate with 4,4'-difluorobenzophenone. The molar ratio 4,4'-difluorobenzophenone: 4,4'-diacetyl diphenyl oxide diketoxime: KOH: K2CO3 is equal to 1:1:2:0.15.
EFFECT: obtained polymer has improved mechanical properties, heat-resistance, and also has a system of properties which are characteristic for both polyether formal oximates and polyether ketones.
2 cl, 3 ex
SUBSTANCE: present invention relates to a method of producing oligo-3,3-bis(azidomethyl)oxetane which is used as a hydroxyl-containing compound for producing energy-intensive polyurethane thermoplastic elastomers. The method involves cationic polymerisation of 3,3-bis(chloromethyl)oxetane in methylene chloride at 20-35°C in the presence of 1-10 wt % boron trifluoride etherate and a diatomic alcohol in molar ratio of 1:(5-15) to 3,3-bis(chloromethyl)oxetane. Further, the intermediate oligo-3,3-bis(chloromethyl)oxetane is separated in finely dispersed form, for which at the end of polymerisation, an organic solvent is added to the reaction mass, methylene chloride is evaporated and oligo-3,3-bis(chloromethyl)oxetane is precipitated with water. Sodium azide is then added to the obtained finely dispersed oligo-3,3-bis(chloromethyl)oxetane in a medium of an organic solvent at 90-130°C in the presence of 0.5-3 wt % tetrabutylammonium bromide.
EFFECT: highly efficient method of producing oligo-3,3-bis(azidomethyl)oxetane and high output of the end product.
5 cl, 1 tbl, 7 ex
SUBSTANCE: disclosed are oligomers based on hexamethylene guanidine derivatives of formula (I), where R denotes or , n1, n2 and n3 equal 1-3, z equals 0.15-1.10; with molecular weight distribution Mw/Mn from 5.4 to 9.3, with weight-average molecular weight Mw 3800-6300 and number-average molecular weight Mn 600-1100. Disclosed also is a disinfectant containing disclosed oligomers as an active component, as well as use thereof.
EFFECT: disclosed compounds have improved and steadily reproducible disinfectant properties, low toxicity and corrosiveness.
4 cl, 1 dwg, 6 tbl, 8 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: inventions relate to field of medicine, veterinary, agriculture and pharmacology and deals with biocidal polyguanidine of formula Acid or (1), method of its obtaining and based on it biocidal composition.
EFFECT: inventions make it possible to obtain biocidal polyguanidine with high antimicrobial activity with wide spectrum of action.
4 cl, 14 tbl, 17 ex
SUBSTANCE: invention relates to chemistry and physics-chemistry of polymers, specifically to novel copolymers of N-vinylcarbazole and N-vinylcaprolactam. The invention also relates to solid solutions of polymethyl methacrylate which contain Tb3+ ions and said copolymers. Described are copolymers of N-vinylcarbazole with N-vinylcaprolactam and solid solutions of polymethyl methacrylate containing Tb3+ ions and copolymers of N-vinylcarbazole with N-vinylcaprolactam.
EFFECT: obtaining metal-polymer solid solutions in polymethyl methacrylate based on copolymers of N-vinylcarbazole with N-vinylcaprolactam of the disclosed composition, characterised by high luminescence intensity between 344 and 700 arbitrary units, and the obtained copolymer solid solutions can be of interest in the design of laser, luminescent, electroluminescent ad high-speed switching devices.
2 cl, 8 ex, 1 tbl, 3 dwg
SUBSTANCE: invention relates to chemistry of high-molecular compounds and specifically to a poly-3,3-bis(azidomethyl)oxetane synthesis method. Poly-3,3-bis(azidomethyl)oxetane is obtained by reacting poly-3,3-bis(chloromethyl)oxetane with sodium azide in a dimethylformamide medium. The poly-3,3-bis(azidomethyl)oxetane is obtained in finely dispersed form which is easy to apply.
EFFECT: poly-3,3-bis(azidomethyl)oxetane synthesis method enables to reduce the amount of dimethylformamide used and also enables to avoid use of methanol.
1 cl, 18 ex, 1 tbl
SUBSTANCE: method of producing copolymers of polyguanidine salts involves treating polyguanidine chloride with a metal compound in an alcoholic solvent, separating the formed metal chloride precipitate through filtration, mixing the filtrate and acid with formation of a copolymer of polyguanidine salts, and subsequent drying the desired product. The polyguanidine chlorides used have general formula , where R is alkylene with straight and branched structure with C4-C12, oxaalkykene[-CH2-]P O[-CH2-]q, dioxaalkylene [-CH2-]P O[-CH2-]q O[-CH2-]r, trioxaalkylene [-CH2-]pO[-CH2-]q O[-CH2-]r O[-CH2-]s, tetraoxaspiroalkylene , n ranges from 2 to 1000; p, q, r, s assume values from 2 to 12, the metal compound used is potassium hydroxide, the alcoholic solvent used is a mixture of ethanol and rectificate with isopropanol in ratio (100-30):(0-70), where the said alcoholic solution of potassium hydroxide is mixed with dry crushed polyguanidine chloride, mixture of organic or mineral (except hydrofluoric) mono- or polybasic acid or mixture acid with filtrate is done after vacuum distillation of alcohol from the filtrate at pressure ranging from 0.1 to 0.2 atm and temperature from 50 to 60°C. Copolymers of polyguanidine salts of general formula: , where R is alkylene with straight or branched structure with C4-C12, oxaalkylene [-CH2-]P O[-CH2-]q, dioxaalkylene [-CH2-]p O[-CH2-]q O[-CH2-]r, trioxaalkylene [-CH2-]P O[-CH2-]q O[-CH2-]r O[-CH2-]s, tetraoxaspiroalkylene, where (n-x): x=19:1-1:19; n=2-100; p, q, r, s assume values from 2 to 12, A is an anion of organic or mineral (except hydrofluoric) mono- and polybasic acid or a mixture of acids.
EFFECT: improvement of method.
3 cl, 4 ex, 4 tbl
SUBSTANCE: present invention relates to new organic polymers of a range of unsaturated polyoximes, which can be used for obtaining polyamines, polyamides, chelating agents, for making medicinal agents, antioxidants, pigments and sealing compounds. Description is given of unsaturated polyoxime with general formula: [-(CHR1)x-CR2=CH-(CHR3)y-]a-[-(CHR1)x-CHR2-C(=O)-(CHR3)y-]b-[-(CHR1)x-CHR2-C(=NOH)-(CHR3)y-]c-[-R4-]d, where: x, y - ranges from 1 to 12; a - from 1 to 2000; b - 0 - 2000; c - from 2 to 2000;d - from 1 to 2000; R1, R2, R3 - hydrogen, alkyl or halogen; R4 - [-CH(C6H5)-CH2-] or [-CH(CN)-CH2-]. Unsaturated polyoxime is obtained from reacting unsaturated polyketone with hydroxylamine at 5-100°C and atmospheric pressure in an organic solvent or a heterophase organic solvent - water system.
EFFECT: unsaturated polyoximes, in contrast to known saturated polyoximes, widen the scope of modifying polymer and potential areas of their use.
8 cl, 10 ex
SUBSTANCE: invention relates to chemistry and specifically to a method of producing arginine bicarbonate. The method involves reaction of an arginine suspension with carbon dioxide at controlled temperature and pressure to form a solution which contains arginine and a bicarbonate anion, and separating arginine bicarbonate from the solution. The arginine suspension contains arginine in form of a free base or in form of a salt and a solvent; pressure ranges from 5 lb/in2 (0.35 kg/cm2) to 250 lb/in2 (17.50 kg/cm2); the arginine suspension is heated to temperature ranging from about 30°C to about 80°C and the solvent is water.
EFFECT: method enables faster production of arginine bicarbonate with considerably higher concentration in the solution.
16 cl, 4 ex
SUBSTANCE: invention relates to an improved method of producing water-soluble zwitterionic (cationotropic) aminoguanidine acrylates which can be used as flocculants in chemical and petrochemical industry and other large-scale production. The obtained compounds can also be used to treat industrial recycled and waste water, in ultrafiltration of enzymes, to deposit polymer latex, stabilise suspensions, food liquids and in production of nanocomposite materials. The compounds have a wide range of biocidal action. The disclosed method involves adding an equimolar amount (with respect to aminoguanidine) of acrylic or methacrylic acid at room temperature in a nitrogen current to a 10% suspension of aminoguanidine carbonate or aminoguanidine bicarbonate in methanol or ethanol and depositing the reaction product after half an hour in diethyl ether.
EFFECT: disclosed method is realised in a single step, does not include fire-hazardous steps of preparing substances such as sodium ethylate, simplifies and cuts the duration of synthesis and extraction of the product, does not require low temperatures and additional purification steps, since carbonic acid formed during the reaction is decomposed to carbon dioxide which is removed from the reaction zone with the nitrogen current.
SUBSTANCE: present invention relates to a method of producing 1-(3,4-dichlorobenzyl)-5-octyl biguanide of formula
or salt thereof, involving reaction of 1-cyano-3-octylguanidine or salt thereof with 3,4-dichlorobenzylamine or salt thereof in an organic ester solvent.
EFFECT: obtaining the desired product with high output using a safe and simple method.
7 cl, 12 ex
SUBSTANCE: method involves treating creatine with pair-toluene sulphonic acid in an organic solvent followed by reaction of the obtained complex with ester or amide derivatives of aliphatic or aromatic amino acids containing a primary or secondary amine group in the presence of a condensing agent and a base which are added successively.
EFFECT: method enables to obtain creatine amides using a much simpler technique and cheap raw material with higher output.
7 cl, 4 tbl, 10 ex
SUBSTANCE: invention relates to zwitterionic organic compounds based on aminoguanidine, acrylic- and methacrylic acid having the following structural formula: , where R=H or CH3, which can be used as biocidal compounds.
EFFECT: high efficiency of the composition.
1 cl, 2 tbl
SUBSTANCE: invention relates to a method of crystallising compounds of formula I or their acid addition salts, , in which R1, R2, R3 assume values given in paragraph 1 of the formula of invention. In the process, corresponding formula I compounds or their mixture with impurities are dissolved at high temperature in water, which is saturated with at least one solvent which is immiscible with water, selected from alkylalkanoates, and optionally contains one or more solvents which are miscible with water, and subjected to crystallisation at lower temperature.
EFFECT: increased purity of product.
5 ex, 7 cl
SUBSTANCE: invention relates to organic chemistry and describes tris-substituted aminoguanidine derivatives of formula , where:.
EFFECT: wider assortment of analytical reagents, used for detecting silver, copper and bismuth cations, and which can be used in analytical, pharmaceutical and chemical-toxicological practice.
2 tbl, 2 ex
SUBSTANCE: invention relates to the heteropolymer salts of hexamethyleneguadinine and method for obtaining it, it is used as a means of disinfecting in medicine, veterinary science, for disinfection of natural and waste water, for protection of the materials of plant and animal origin, for example, of wood, cotton the skin, fur from biodegeneration, as well as in other sectors of national economy, where biocidal products are required. Heteropolymer salts of hydrochloride, phosphate and sodium dihydroorthophosphate of hexamethyleneguadinine of the following formula: , where: A=5-25 mol%; B=60-90 mol%; C=5-30 mol%, can be obtained in two ways. The first method of obtaining heteropolymer salts consists in adding and mixing up of the base of poly- hexamethyleneguadinine, dissolved in ethyl alcohol or in water, with hydrochloric acid, phosphoric acid and 30% aqueous solution of sodium dihydroorthophosphate, or with hydrochloric acid, phosphoric acid and aqueous sodium hydroxide. Then the obtained heteropolymer is separated and fried. Initial components are take in the following molar relationship base poly-hexamethyleneguadinine: hydrochloric acid: phosphoric acid: solution of sodium dihydroorthophosphate - 1: 0.05-0.25 : 0.60-0.90 : 0.05-0.30, or in the following molar relationship of the base poly- hexamethyleneguadinine: hydrochloric acid; phosphoric acid; solution of sodium dihydroorthophosphate - 1: 0.05-0.25 : 0.65-1.20 : 0.05-0.30. The second method of obtaining the heteropolymer salts consists in that to the hydrochloride of poly- hexamethyleneguadinine, dissolved in ethyl alcohol, alcoholic solution of sodium hydroxide obtaining the mother liquor, to which phosphoric acid and 30% aqueous solution of sodium dihydroorthophosphate is added while mixing. The obtained heteropolymer is dried. The initial components are put in the following molar relationship: hydrochloride of the poly- hexamethyleneguadinine; alcoholic solution of sodium hydroxide: phosphoric acid: solution of sodium dihydroorthophosphate - 1: 0.75-0.95 : 0.60-0.90 : 0.05-0.30.
EFFECT: invention enable to obtain heteropolymer salts with high antimicrobial activity.
4 cl, tbl, 7 ex
FIELD: organic chemistry, medicine, cardiology.
SUBSTANCE: invention describes compounds of the formula (I): wherein R1 and R2 mean hydrogen atom (H), alkyl, fluorine (F), chlorine (Cl), bromine (Br) atom, alkoxy-group, -S(O)nR7, polyfluoroalkyl, polyfluoroalkoxy-group; R3 means Alk-R8, cycloalkyl; R8 means H, cycloalkyl, polyfluoroalkyl, phenyl or -OH; R4, R5 and R6 mean H or alkyl; R7 means alkyl. Also, invention relates to a method for synthesis of these compounds and a pharmaceutical composition possessing inhibitory activity with respect to Na+/K+ cellular exchange. Proposed compounds are suitable as anti-arrhythmic medicinal agents with a cardioprotective component used in prophylaxis of infarction and treatment of infarction and treatment of stenocardia. Compounds inhibit also pathophysiological process by prophylactic effect associated with development of disorders induced by ischemia, in particular, arising ischemia-induced cardiac arrhythmia and cardiac insufficiency.
EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.
17 cl, 59 ex
SUBSTANCE: invention refers to disinfection. The experimental method for the elimination of pathogenic and opportunistic microorganisms is characterized by the fact that a mixture containing the pathogenic and opportunistic microorganisms are processed with a disinfection composition which is metal oxyhydrate gel prepared by alkaline metal chloride deposition by 2% ammonia in a min. 5-litre reactor; fresh metal oxyhydrate 20-10-6 m3 is placed in an electrochemical cells with graphite electrodes of a charged cluster metal particle generator; what is added is a bacterial solution of the medium of 105 microbial cells in 1 ml dissolved in distilled water 10 ml; the medium is exposed to polarized currents of the cluster oxyhydrate particles of metal oxyhydrate gel for 2 to 6 hours; metal oxyhydrate gels are prepared by using metal chloride salts presented by zirconium or iron chloride salts with the electrode distance no more than 70 mm.
EFFECT: invention provides the more effective inactivation of pathogenic and opportunistic microorganisms that are infectious agents in human and animals.
7 tbl, 2 dwg, 6 ex