Oil-in-water emulsion composition

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to cosmetic industry and represents an oil-in-water emulsion composition for UV protection, containing: (a) octocrylene, (b) bis- ethylhexyloxyphenol methoxyphenyl triazine, (c) hexyldiethylamino-hydroxybenzoyl benzoate, (d) 4-tert-butyl-4'-methoxybenzoyl methane, wherein the amount of the ingredients (a), (b), (c) and (d) makes 1 - 40 wt/wt %, (e) a water-soluble polymer in the amount of 0.01-5 wt/wt %, (f) a water-swellable clay mineral in the amount of 0.01-4 wt/wt %, (g) an oil ingredient having NOB 0.05 or more in the amount of 1 - 70 wt/wt %, (h) a higher fatty acid in the amount of 0.1-10 wt/wt %, (i) a surfactant in the amount of 0.1-10 wt/wt %, (j) water - the rest, wherein all the amounts are presented as a percentage of the total amount in the oil-in-water emulsion composition.

EFFECT: invention provides developing the composition having the good UV protection effect, exhibiting the emulsion stability and pleasant sensation.

6 cl, 8 ex, 4 tbl, 1 dwg

 

The technical FIELD

The present invention relates to emulsion compositions are oil-in-water". More specifically it relates to emulsion compositions are oil-in-water", which contains specific absorbent of ultraviolet rays and polar oil. The emulsion composition of the oil-in-water according to the present invention is preferably used as a sunscreen cosmetic.

PRIOR art

Important areas wavelength ultraviolet light absorbed by the sunscreen cosmetics are region UV-a (320-400 nm) and the region of UV-b (290-320 nm). Believed that the UV light in the UV-A (320-400 nm) darkens the skin, but it should not cause sunburn and accelerate skin aging in contrast to UV light in the UV-b (290-320 nm). However, in recent years it has become clear that, although the UV light in the UV-b (290-320 nm) only reaches the surface of the skin, ultraviolet light in the UV-A (320-400 nm) reaches the deeper parts of the skin and induces not only aging, but also skin cancer.

The ultraviolet rays absorbents for cosmetics, which are used up to the present time, divided by the structure on categories: (1) derivatives benzoic acid, (2) derivatives of cinnamic acid, (3) derivatives of benzophenone, (4) derivatives dibenzoylmethane the and and (5) derivatives of salicylic acid. In recent years, often used absorbents ultraviolet rays (2)and(4).

However, each of these absorbers of ultraviolet rays has problems from a practical point of view. For example, 2-ethylhexyl-para-dimethylaminobenzoate, example (1) derivatives of benzoic acid, is a transparent liquid and has the advantage of ease of handling; however, this compound and its derivatives are questionable in terms of safety, and therefore, in recent years do not apply them. Also, the wavelength of its absorption is about 290 nm, and it absorbs only UV light in the UV-C.

Among (2) derivatives of cinnamic acid 2-ethylhexyl-para-methoxycinnamate is the most commonly used absorbent of ultraviolet rays in the sun cosmetics care, currently available for sale. Its maximum absorption wavelength is about 310 nm, and the absorption does not reach the UV-A. in Addition, sunlight destroys it, and therefore there are problems with staining, as well as instability of the protective effect of ultraviolet rays.

As for (3) derivatives of benzophenone, 2-hydroxy-4-methoxybenzophenone, for example, absorbs both UV-a and UV-b and shows a relatively good solubility in the Gentech, form the basis of the external drug; however, its maximum absorption wavelength closer to the UV-b, and the absorption is not very high. In recent years, its structural skeleton (benzophenone) attributed to the properties of the hormone to the environment, and its application to avoid it.

Among (4) derivatives dibenzoylmethane 4-tert-butyl-4'-methoxybenzanilide often used for outdoor products. Its absorption maximum is at about 360 nm, and the absorption rate is high, and therefore, he is the best absorbent of ultraviolet rays in the UV-A. However, there is a problem of its photostability, and he was weak compatibility with oil components in external drugs and, therefore, can be added only in small quantities.

Among (5) derivatives of salicylic acid applied octisalate. It has a maximum absorption wavelength in the UV-b and is in oil form, and also exhibits better compatibility with vaseline oil and the like; however, since the absorption is low, it is of little use in practice.

Therefore, 2-ethylhexyl-para-methoxycinnamate of (2) is often used for the UV-b and 4-tert-butyl-4'-methoxybenzanilide of (4) is often used for the UV-A. In recent years, in cast the STI,, there is an increasing need to absorb ultraviolet rays in the UV-A.

Some absorbents ultraviolet rays are sticky, which can be a significant problem when they are administered in sunscreen cosmetic products, for which the feeling when the application is considered important. That is, when the fraction of the absorbent of ultraviolet rays in the mixture increases for higher absorption effect of ultraviolet rays, the feeling when applying rapidly deteriorating. Therefore, there are cases where the desired proportion in a mixture of the desired absorbent of ultraviolet rays cannot be achieved.

In addition, as a rule, in order to guarantee a wide range of acquisitions practice blending of a variety of absorbents ultraviolet rays in sunscreen cosmetic tool.

However, in the case of sunscreen cosmetics containing absorbent of ultraviolet rays, the feeling in use, may deteriorate. Because a good feeling when use is an important element in a high degree required for cosmetic products, usually do not practice the blending of a variety of absorbents ultraviolet rays, in particular 3, 4 or more different types, even to ensure a wide range of absorption.

Meanwhile, the derivative d is benzoylamino, entered in cosmetics as absorbers of ultraviolet rays, lose some

the ability to absorb UV rays under the action of ultraviolet light. The developed technology, which is used as a derivative dibenzoylmethane, and α-cyano-β,β-diphenylacetate, which is another absorbent of ultraviolet rays, to combat this phenomenon and warranties of photostability (patent document 1).

In addition, in the case of cosmetic products, which apply both absorbent of ultraviolet rays, a derivative of 1,3,5-triazine and derived dibenzoylmethane, a derivative of 1,3,5-triazine significantly chemically decomposes ultraviolet radiation in the presence of 4-tert-butyl-4'-methoxydibenzoylmethane. Therefore, the developed technology, which is additionally used α-cyano-β,β-diphenylacetate to ensure the photostability of a derivative of 1,3,5-triazine and derived dibenzoylmethane (patent document 2).

However, when technology, which guarantees the photostability of the absorbers of ultraviolet rays by the use of multiple absorbers of ultraviolet rays, there is a problem. Since many solid absorbents ultraviolet rays have low compatibility with oil components, which represent the Oh is the main agent for cosmetics, and hardly soluble in them, therefore, if they should be stably introduced into the cosmetic, it is necessary to add a large number of specific oil components having the best compatibility. The presence of specific oil components in large quantities should cause a decrease in stability of cosmetic products (in particular, the stability of emulsification emulsion cosmetic oil-in-water) and the deterioration of the feeling when applied.

As described so far, the joint use of multiple absorbers of ultraviolet rays is responsible for the deterioration of stability and feeling upon application of cosmetics, and therefore, usually do not practice the blending of a variety (in particular, four or more types of different absorbers of ultraviolet rays in sunscreen cosmetic tool.

In addition, there are several reports about the stability of the emulsion (in particular, stability, dissolution absorbers of ultraviolet rays at lower temperatures) in cases where four or more absorbers of ultraviolet rays is injected into the emulsion composition of oil-in-water".

The documents of the prior art:

{Patent documents}

Patent document 1: Japanese patent No. 2975682

atentry document 2: Japanese patent No. 3714632

DISCLOSURE of INVENTIONS

TECHNICAL TASK

With the aim of obtaining high protection from UV rays in the UV-a and the UV-b, you must enter the ultraviolet rays absorbents such a way that the absorbent UV-a and UV absorbents-In was in good balance.

However, since many conventional absorbent UV-a hardly soluble in the mixture it is necessary to introduce a large number of highly polar oil component to dissolve them, making it difficult to obtain stable principal agent emulsion composition of the oil-in-water.

In addition, there were many problems, such as deterioration in the stability of emulsification and sensations in the application, when seeking to obtain a sunscreen cosmetic products, which represented the emulsion composition of the oil-in-water containing four or more absorbers of ultraviolet rays.

In light of the above problems, the inventors have conducted serious research on sunscreen cosmetic products that have the best effect of the absorption of ultraviolet rays, as well as better stability of emulsification and feeling upon application, and made the discovery that the emulsion composition of the oil-in-water and sunscreen cosmetics that are the best protective effect from ultra is violet rays and are the best in terms of stability of emulsification and feeling upon application, can be obtained by introducing the mixture into a combination of four specific absorbents, UV rays and specific cosmetic ingredients, thus completing the present invention.

The aim of the present invention to provide an emulsion composition of the oil-in-water sun cosmetics, which shows the best effect of the absorption of ultraviolet rays are the best in terms of stability of emulsification and sensation when applied.

TECHNICAL SOLUTION

Thus, in the present invention proposed emulsion composition of oil-in-water"containing the following components (a)to(K).

(a) Octocrylene

(b) bis-Ethylhexyloxymethyl

(C) Heksildiantipirilmetan

(d) 4-tert-Butyl-4'-methoxybenzanilide

(d) a water-Soluble polymer

(e) Swelling in water of clay mineral

(g) an Oil component having a NOB 0.05 or more

(C) Higher fatty acid

(and) Surfactant

(K) Water

Also in the present invention proposed the emulsion composition of the oil-in-water, where the proportion in the mixture of the specified "(e) swelling in water of mineral" is 0.01-4% mass/mass of the total quantity of the above-mentioned emulsion composition of the oil-in-water.

Further, in the present invention before Agena emulsion composition "oil in water", where the proportion in the mixture of the specified "(g) an oil component having a NOB of 0.05 or more is 20-75% mass/mass of oil phase.

Also in the present invention proposed emulsion composition "oil in water", where the "(d) water-soluble polymer is a polysaccharide.

In addition, in the present invention proposed emulsion composition "oil in water", where the "(e) an oil component having a NOB 0.05 or more" is an essential oil.

Also in the present invention proposed the emulsion composition of the oil-in-water, where the proportion in the mixture of components (a) octocrylene, (b) bis-ethylhexyloxymethyl, (C) getservicemanager-benzoylbenzoate and (d) 4-tert-butyl-4'-methoxybenzylidene is 10-25% mass/mass of the total quantity of the emulsion composition of the oil-in-water.

In addition, in the present invention proposed sunscreen cosmetic comprising the above-mentioned emulsion composition of the oil-in-water.

BENEFICIAL EFFECTS

The emulsion composition of the oil-in-water according to the present invention shows the best protective effect against UV rays and is the best in terms of stability of emulsification and sensations when applied, and can therefore be offered the best sunscreen cosmetic with adsto.

A BRIEF DESCRIPTION of GRAPHIC MATERIALS

Figure 1 shows the absorption curves of Examples and Comparative examples.

The BEST WAY of carrying out the INVENTION

The present invention is described in detail below.

"Absorbent of ultraviolet rays"

Four types of ultraviolet rays absorbents, which is introduced into the mixture in the present invention are (a) octocrylene, (b) bis-ethylhexyloxymethyl, (C) getservicemanager-benzoylbenzoate and (d) 4-tert-butyl-4'-methoxybenzoate (t-butylperoxybenzoate). Each of them is an absorbent of ultraviolet rays prior art.

"(a) Octocrylene" (2-ethylhexyl-2-cyano-3,3-diphenylacetate) commercially available as, for example, "Parsol 340" (from DSM Nutritional Products).

"(b) bis-Ethylhexyloxymethyl" commercially available as, for example, "TINOSORB S" (from Ciba Specialty Chemicals).

"(C) Heksildiantipirilmetan" commercially available as, for example, "Juvenil plus granular" (from BASF JAPAN).

"(d) 4-tert-Butyl-4'-methoxybenzanilide" commercially available as, for example, "Parsol 1789" (from DSM Nutritional Products).

The proportion in the mixture of the above four types of ultraviolet rays absorbents determine, as appropriate for the product. The total number of four types, which should be put in the mixture, usually what is about 1-40% mass/mass, preferably 5-30% mass/mass, and more preferably 10-25% mass/mass of the total quantity of the emulsion composition of the oil-in-water. If their total number is less than 1% mass/mass, then absorbing effect of the absorbent of ultraviolet rays is evident enough; if it is more than 40% mass/mass, there is stickiness.

"Water soluble polymer"

Examples of "(d) water-soluble polymer used in the present invention include polysaccharides, such as xanthan gum, carrageenan, pectin, mannan, curdlan, chondroitin-sulphuric acid, starch, galactan, dermatan sulfate, glycogen, gum Arabic, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, muhittin-sulfuric acid, gidroxiatilkrahmala gum, carboximetilcelulosa gum, guar gum, carob bean gum, dextran, keratolytic, carob bean gum, actinopyga, Aronova acid, chitin, chitosan, carboxymethylchitin, mucilage of quince seeds, starch (rice, corn, potato, wheat), glycyrrhizin, pullulan and agar.

Examples of cellulosic polymers include methyl cellulose, ethyl cellulose, methylhydroxypropylcellulose, hydroxyethyl cellulose, cellulose sulfate sodium, guide Roxy Pro drank cellulose, carboxymethyl cellulose, is dicarboximides, crystalline cellulose and powdered cellulose

Examples of the vinyl polymer include polyvinyl alcohol, polivinilbutilovy ether, polyvinylpyrrolidone and carboxyvinyl polymer.

Examples of the acrylic polymer include sodium polyacrylate, politicalit and polyacrylamide.

The proportion of water-soluble polymer in the mixture is usually from 0.01 to 5% mass/mass, preferably 0.01 to 1% mass/mass and more preferably 0.1 to 0.5% mass/mass of the total quantity of the emulsion composition of the oil-in-water. If the proportion in the mixture is less than 0.01% mass/mass, the stability of emulsification of the composition becomes weak, and if it is above 5% mass/mass, applying feel the stickiness.

"Swelling in water of clay mineral"

"(e) Swelling in water, the clay mineral used in the present invention is a layered silicate mineral that belongs to the smectite group; common examples include montmorillonite, beidellite, nontronite, saponite, hectorite and bentonite. They can be either natural or synthesized. Commercial products include Kunipia, Smectone (both from the company Kunimine Industries Co., Ltd.), Laponite (from Laporte Industries, Inc.), synthetic phlogopite bearing fluoride sodium type (Submica E from Daito Kasei Kogyo Co., Ltd.), and granules Veegum Ultra (from R.. Vanderbilt Company, Inc.). Among them, particularly preferred is entrusted Kunipia and Smectone.

The percentage of swelling in water of the clay mineral in the mixture is typically from 0.01 to 4% mass/mass, preferably 0.01 to 2% mass/mass and more preferably 0.01 to 1% mass/mass of the total quantity of the emulsion composition of the oil-in-water. If the proportion in the mixture is less than 0.01% mass/mass, the stability of emulsification of the composition becomes weak, and if it is above 4% mass/mass, deteriorating its distribution on the skin.

"Oil component having a NOB 0.05 or more"

The oil component used in the present invention is a polar oil having a NOB 0.05 or more, preferably an essential oil having a NOB of 0.05 to 0.8. Specific examples include isononylphenol, isopropylmyristate, etilgexanol, octyldodecanol, isopropyl, butilstearat, exellent, myristoleate, decillia, hexyldecanoic, catallactic, myristylated, linolenate, isolatedstore, societalization, cholesteryl-12-hydroxystearate, ethylene glycol-di-2-ethylhexanoate, ether dipentaerythritol and fatty acids, N-alkylchlorosilanes, neopentylglycol, diisostearate, glycerin di-2-heptylaniline, trimethylolpropane-tri-2-ethylhexanoate, trimethylolpropane, pentaerythritol-Tetra-2-ethylhexanoate, glycerin-tri-2-ethylhexanoate, trimethylolpropane teart, cetyl-2-ethylhexanoate, 2-ethylhexylamine, diethylhexylphthalate, alkylbenzoic (12-15 carbon atoms), clearlistener, glycerine-(kaprilat/capret), butyleneglycol(dicaprylate/capret), glyceryltrinitrate, three 2-gertrudekegler, methyl ester of fatty acids of castor oil, aerolef, cetosteatil alcohol, acetoglyceride, 2-heptylaniline, diisobutylamine, 2-octyldodecyl-N-lauroyl-L-glutamate, di-2-gamelogic.java, tillaart, di-2-ethylhexylcarbonate, 2-hexidecimal, 2-hexidecimal, 2-hexidecimal, Diisopropylamine, 2-ethylhexylacrylate, ethyl acetate, butyl acetate, amylacetate, triethylcitrate, 2-ethylhexyl-para-methoxycinnamate and tripropyleneglycol. Among them, particularly preferred isononylphenol, glyceryl-2-ethylhexanoate, cetyl-2-ethylhexanoate and Diisopropylamine.

NOB abbreviation of the term "inorganic/organic balance", which shows the values for inorganic to organic value and is a measure of the degree of polarization of the organic compound. Is NOB specifically expressed as "value NOB = inorganic value/organic value. As for the "inorganic value" and "organic value" in this application, each atom or functional group in front of the OLE attribute "inorganic value" and "organic value", as, for example, "organic value" 20 for one atom of carbon and an inorganic value of 100 for a group of hydroxide, and the value NOB organic compounds can be calculated by summing "inorganic values" and "organic value" of the atoms and functional groups in a specified organic compound (see, for example, "Called no Ryoiki (Areas of Chemistry)" by Fujita, 1957, volume 11, issue 10, p 719-725).

The share of oil component having a NOB 0.05 or more in the mixture is usually 1-70% mass/mass, preferably 3-50% mass/mass, and more preferably 5-30% mass/mass of the total quantity of the emulsion composition of the oil-in-water.

Also preferably, the share of the oil component having a NOB 0.05 or more, the oil phase was 20-75% mass/mass. The oil phase represents the ingredients are oil-based, including ultraviolet rays absorbents (a)-(g) and surfactant.

"Higher fatty acid"

In the present invention in relation to the stability of the emulsification emulsion composition of the oil-in-water preferably introduction in the mix "(C) higher fatty acid. Specific examples include lauric acid, myristic acid, palmitic acid, stearic acid, beenbuy acid, oleic acid, undecylenoyl acid, taly oil, isostearoyl acid, linoleic acid and linolenovuyu acid. Among them preferable to use stearic acid and beenbuy acid. For fatty acids acceptable education Soaps of the fatty acid in the emulsion composition of the oil-in-water.

In the present invention, the proportion of fatty acid in the mixture is typically 0.1-10% mass/mass, preferably 0.1 to 5% mass/mass of the total quantity of the emulsion composition of the oil-in-water. More preferably, it is 0.5-2% mass/mass.

"Surfactant"

In the present invention "(and) surfactant" is introduced into the mixture for emulsion composition of the oil-in-water, surfactant used in the present invention, determine, as appropriate, but preferably using a lipophilic non-ionic surfactant and/or hydrophilic non-ionic surfactant. Examples of the surfactant that can be used in the present invention, below.

Examples of hydrophilic nonionic surfactant include PoE alkilany ether, PoE alkylphenolic ether, PoE-POP alkilany ether, so the fatty acid ester, PoE ether sorbitan and fatty acid, PoE ester of glycerol and fatty acids, so derivatives of castor oil or hydrogenated castor oil, PoE-derived bees wax - lanolin, alkanolamide, so ether of propylene glycol and fatty acids, so alkylamino, so amide of fatty acids, sucrose esters and fatty key is lots silicone (silicone compound), a modified polyester. They can be used independently or in combinations of two or more.

"CPE" means polyoxyethylene and "POP" means polyoxypropylene; they may be so indicated below.

Among the above-mentioned hydrophilic non-ionic surfactants are especially preferred nonionic surfactants of the type of adduct of ethylene oxide having an HLB of 8 or more; examples include PoE (10-50 mol) of the ester phytosterol, PoE (10-50 mol) ether dihydrocholesterol, CPE (10-50 mol) 2-octyldodecyl ether, PoE (10-50 mol) decyltetradeceth ether, PoE (10-50 mol) alerby ether, PoE (10-50 mol) cetyl ether, PoE (5-30 mol) POP (5-30 mol) 2-decyltetradeceth ether, PoE (10-50 mol) POP (2-30 mol) cetyl ether, PoE (20-60 mol) servicemanual, CPE (10-60 mol) servicemonitor, CPE (10-80 mol) glycerylmonostearate, CPE (10-30 mol) glycerylmonostearate and CPE (20-100) derivatives of hydrogenated castor oil.

Examples of lipophilic nonionic surfactant include servicemanual, servicesecurity, sarbatorile, servicemonitor, servicesarchitecture, glycerylmonostearate, glycerylmonostearate, glycerylmonostearate, glycerylmonostearate, digitainment, diglycerides, DigitalMaster, diglycidylether, demilitarisation, Dec is glycerylmonostearate, demilitarization, decapitalization, the sucrose monooleate, CPE (2 mol) monooleate, PoE (6 mol) diisostearate and CPE (3-10 mol) derivatives of castor oil.

The proportion of the surfactant mixture is determined by expediency; it is usually 0.1 to 10% mass/mass, preferably 0.1 to 5% mass/mass and more preferably 0.5 to 3% mass/mass, the total amount of the emulsion composition of the oil-in-water.

"Water"

In the present invention, the proportion(to) water in the mixture is preferably 50-90% mass/mass of the total quantity of the emulsion composition of the oil-in-water. Ingredients water-based, such as "(d) water-soluble polymer and(e) swelling in water, the clay mineral is dissolved in water to form the aqueous phase.

The emulsion composition of the oil-in-water according to the present invention can be obtained using conventional manner by suitable mixing of the above-mentioned essential ingredients as needed with additional other components that are commonly used in cosmetics, such as powder components, liquid fats and oils, solid fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, essential oils, silicone oils, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, moisturizers, C is hostitel, covering agents, stabilizers, lower alcohols, polyhydric alcohols, sugars, amino acids, organic amines, polymer emulsions, agents that regulate the pH, nutrients for skin, vitamins, antioxidants, excipients, prevent oxidation, and flavorings.

The emulsion composition of the oil-in-water according to the present invention is preferably used as a sunscreen cosmetic. The preferred products are sunscreen emulsion/M, sunscreen emulsion, sunscreen lotions, etc.

EXAMPLES

Further, the present invention is described in detail below with reference to Examples. The present invention is not limited to these Examples. The ratio of mixture components in the Examples are given in units of % mass/mass (percent by weight), unless otherwise indicated.

A (aqueous phase) and b (oil phase) in the following table 1 and table 2 was heated up to 70°C and is fully dissolved. And added it In, and then she emulsiable an emulsifier to obtain an emulsion composition of the oil-in-water (sunscreen cosmetic product in the form of a cream).

"Stability of emulsification"

The resulting composition is hermetically closed in a 50 ml test tube with screw cap and stored for four weeks at 50°C; then stability is of mulgrove was evaluated on the basis of appearance.

<Rating>

Saved layer state:

Splits: x

The result (see table 1) in Comparative examples 1 and 2, which had only "(d) water-soluble polymer (xanthan gum), was divided, whereas Example 1, which had a small amount of(e) swelling in water of clay minerals (smectite), showed good stability without sacrificing sensation when applied.

Comparative example 3 (see table 1), which contained only "(d) water-soluble polymer (xanthan gum), showed separation. In addition, Comparative examples 4-5, which had xanthan gum as a "(d) water-soluble polymer and actinopyga as another "(d) water-soluble polymer, showed separation, and the feeling during use was also damaged. On the contrary, Examples 2-5, which had "(e) swelling in water clay mineral (bentonite), showed good stability. Of these Examples 2-3 also gave a good feeling when applied.

"The feeling in the application"

<Rating>

Commission of ten women actually put the samples on the skin and estimated distribution (easily) on the basis of the following standards.

a: Eight or more believed that the sample is distributed easily.

Δ: From three to seven believed that the way the C is distributed easily.

x: Two or less believed that the sample is distributed easily.

Table 1
Comparative example 1Comparative example 2Example 1
The aqueous phase(K) Ion-exchange waterRestRestRest
95 ethyl alcohol, synthesized5,05,05,0
1,3-Butyleneglycol5,05,05,0
Glycerin5,05,05,0
(d) xanthan gum0,10,30,1
(e) Smectone (from Kunimine Industries Co., Ltd)--0,1
Triethanolamine0,250,250,25
EDTA-3Na·2H2O0,10,10,1
Phenoxyethanol0,50,50,5
The oil phase(and) Glycerylmonostearate1,51,51,5
(and) so glycerylmonostearate1,51,51,5
(C) Baganova acid111
The copolymer of polyvinylpyrrolidone/eicosene2,02,02,0
Batrawy alcohol0,50,50,5
Beganovic alcohol11
(g) Isononylphenol101010
(g) Glyceryl-tri-2-ethylhexanoate555
(a) Octocrylene101010
(b) bis-ethylhexyloxymethyl333
(C) Heksildiantipirilmetan333
(d) 4-tert-butyl-4'-methoxydibenzoylmethane333
Dimethyldiselenide malonate555
FlavorAn appropriate numberAn appropriate numberAn appropriate number
Only 100100100
ScoreThe stability of emulsificationxxo
The feeling when appliedooo

"The effect of absorption of ultraviolet rays"

50 ál of the samples from Examples 1 and 2 and Comparative example 6 were evenly applied onto nylon membrane (5×5 cm) at a density of 2 mg/cm2; after this was allowed to stand for 15 minutes, and for measurements of absorption used a spectrophotometer (U-4100 from Hitachi, Ltd.). The results are presented in figure 1. Figure 1 shows that the absorption of the UV rays of Examples 1 and 2 is significantly better than Comparative example 6. Sacs (sun protection factor) and Sz (protection grade of UVA) of the Comparative example is 34 and +++, respectively; thus, sunscreen cosmetics of Examples 1 and 2 have PCs 30 or higher and NW +++ or higher, which confirms the fact that they have high performance PCs and Sz.

The composition of Comparative example 6 are shown in table 3. Comparative example 6 is a standard drug for comparison, the effect is the absorption of ultraviolet rays, and this drug has the best effect of the absorption of ultraviolet rays, that is, the PCs 30 and NW+++.

Table 3
Comparative example 6
(K) WaterRest
Ethanol7
Glycerin2
Carbomer0.3
(d) Xanthan gum0.2
(and) Polyoxyethylenesorbitan castor oil1.5
(and) Silicone-modified polyester1
Decamethylcyclopentasiloxane12
Ezoterikova acid1
(g) Isononylphenol2
The titanium oxide5
Octyl-para-methoxycinnamate5
(a) Octocrylene2
(C) Heksildiantipirilmetan0.5
EDTA-3Na0.5
Phenoxyethanol0.5

"Solubility of an absorbent of ultraviolet rays"

Experienced solubility (b) bis-ethylhexyloxyphenol-phenyltriazine, (C) heksildiantipirilmetan and (d) 4-tert-butyl-4'-methoxybenzylidene in various oil components at 0°C at a concentration of 1.5% mass/mass.

As a result, the deposition was observed for oil components having NOB 0, but not for oil components having NOB 0.05 or more. Thus, it is demonstrated that the ultraviolet rays absorbents (b)-(d) have excellent solubility in oil components, with NOB 0.05 or more. Therefore, in the present invention proposed a stable emulsion compositions are oil-in-water", which is not precipitated absorbent of ultraviolet rays.

"Example 6" Sunscreen emulsion

Dipropyleneglycol5
Xanthan gum 0,1
Bentonite1
Stearic acid0,5
Palmitic acid0,5
Polyoxyethylene glyceryltrinitrate1
Glycerylmonostearate1
Polyoxyethylene glycerylmonostearate1
The copolymer of polyvinylpyrrolidone/eicosene
Dipropylenetriamine
The pentaerythritol-Tetra-2-ethylhexanoate
Isopropylcarbonate
Octocrylene
Heksildiantipirilmetan
2-Ethylhexyl-para-methoxycinnamate
Ethylhexylacrylate
Sodium hexametaphosphate
EDTA-3Na
Triethanolaminean appropriate number
Preservativean appropriate number
Distilled waterrest
Flavoran appropriate number

"Example 7" Sunscreen emulsion

Glycerin5
Xanthan gum0,3
Smectone (from Kunimine Industries Co., Ltd.)0,5
Stearic acid0,5
Ezoterikova acid0,5
Stearyl alcohol2
Polyoxyethylene hydrogenated castor oil1
Polyoxyethylene glycerylmonostearate1
Trimethylcyclohexylamine acidCyclomethicone3
Caprolacton3
Tetracylcine10
2-Ethylhexyl-2-ethylhexanoate3
Octocrylene5
bis-Ethylhexyloxymethyl2
Heksildiantipirilmetan2
4-tert-Butyl-4'-methoxybenzanilide2
Phenylbenzimidazole acid1
Ascorbic acid glucoside2
EDTA-3Na0,1
The potassium hydroxidean appropriate number
Preservativean appropriate number
Distilled waterRest
Flavorsuitably the e number

"Example 8" Sunscreen emulsion

Alcohol5
Dipropyleneglycol5
Xanthan gum0,1
Bentonite1
Glycerylmonostearate1
Polyoxyethylene glycerylmonostearate1
Baganova acid1
Beganovic alcohol2
Trimethylcyclohexylamine acid1
Cyclomethicone3
Dimethicone2
Isopropylmyristate5
Ektralite5
Diethylhexylphthalate1
Polyoxyethyleneglycol1
Octocrylene5
bis-Ethylhexyloxymethyl2
Heksildiantipirilmetan2
4-tert-Butyl-4'-methoxybenzanilide2
Sodium hydroxyethanesulfonic1
Methylene-bis-benzothiazolylsulfenamide2
EDTA-3Na0,1
Triethanolaminean appropriate number
Preservativean appropriate number
Distilled waterRest
Flavoran appropriate number

INDUSTRIAL APPLICABILITY

The present invention provides an emulsion composition "oil in water", which shows the best effect of the absorption of ultraviolet rays and is the best in terms of stability of emulsification and sensation when applied. The emulsion composition of the oil in the de" of the present invention is preferably used as a sunscreen cosmetic.

1. The emulsion composition of the oil-in-water to protect from UV rays, contains:
(a) Octocrylene
(b) bis-Ethylhexyloxymethyl
(C) Heksildiantipirilmetan
(d) 4-tert-Butyl-4'-methoxybenzanilide, where the number of components (a), (b), (C) and (d) is 1 to 40% wt./wt.,
(d) a water-Soluble polymer in an amount of 0.01-5% wt./wt.,
(e) Swelling in water of clay mineral in an amount of 0.01-4% wt./wt.,
(g) an Oil component having a NOB 0.05 or more, the amount of 1-70% wt./wt.,
(C) Higher fatty acid in an amount of 0.1-10% wt./wt.,
(s) Surfactant in an amount of 0.1-10% wt./wt.,
(K) Water - the rest,
where all quantities are given in percent of the total emulsion composition of the oil-in-water.

2. The emulsion composition of the oil-in-water according to claim 1, where the proportion of the component (W) - oil component having a NOB 0.05 or more, the oil phase is 20-75% wt./wt.

3. The emulsion composition of the oil-in-water according to claim 1, where component (d) is a water - soluble polymer is a polysaccharide.

4. The emulsion composition of the oil-in-water according to claim 1, where component (W) - oil component having a NOB 0.05 or more, represents the essential oil.

5. The emulsion composition of the oil-in-water according to any one of claims 1 to 4, where the total proportion of components (a) octocrylene, (b) bis-e is electronictelecommunication, (C) heksildiantipirilmetan and (d) 4-tert-butyl-4'-methoxybenzylidene in the mixture is 5 to 30% wt./wt. the total amount of the emulsion composition of the oil-in-water.

6. Sunscreen cosmetic containing emulsion composition of the oil-in-water according to any one of claims 1 to 5.



 

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2 ex

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