Cosmetic products based on molecular imprinted polymers

FIELD: medicine, pharmaceutics.

SUBSTANCE: claim describes a cosmetic or dermatological composition in the form of cream, foam, spray, gel, gel spray, lotion, oil, oil gel or mousse. The composition contains at least one active substance, at least one molecular imprinted polymer in the presence of the same active substance, and at least one oil phase. The polymer contains a) a monoethylene-saturated mono- or dicarboxylic acid or α,β-ethylene-unsaturated mono- or dicarboxylic acid esters with diols and b) methacrylic acid esters of at least dihydric alcohols. The molar ratio of the compounds a) and b) makes 1:2 to 1:4, and the polymer is prepared in the medium of a solvent wherein monomers, but not the polymer to be prepared is dissolved in the presence of the active substance.

EFFECT: combination of the molecular imprinted polymer prepared by precipitative polymerization, and the oil phase provides the release of the active substance both in the water phase, and in the oil phase which ensures the best contact with a lipophilic surface, such as skin.

3 cl, 3 dwg, 7 tbl, 37 ex

 

The object of the present invention is a cosmetic or dermatological preparations containing at least one active ingredient, at least one polymer, molecular imprinted in the presence of this active substance, and at least one fatty phase.

During the development of cosmetic products for achieving special effects, crucial proper choice of ingredients. Huge range currently offer market components and raw materials for cosmetic compositions continues to expand as the consumer is interested in purchasing their demands effective products such as cosmetic products, can prevent signs of aging. Manufacturers of cosmetic products also have a particular interest in active substances that can restore the skin or to protect it from the effects caused by light aging. Before such active substances primarily served to smooth and moisturize skin, but today their range is supplemented by a number of different substances that have physiological effects. Examples of such substances are vitamins, fruit acids, and ceramides. When this increasingly important methods of stabilization is one of the active substances. In the field of cosmetics have been showing great interest in active substances, are able to maintain stability in aqueous or water-containing systems.

To maintain the effectiveness unstable against heat, oxidation-sensitive or volatile cosmetic or dermatological active substances they seek to protect directly in the drug.

Often there is a need to ensure long-term release of cosmetic or dermatological active substances (so-called controlled release).

To ensure a controlled release of cosmetic active substances in some areas is well justified, for example, the use of polymer microcapsules, which would also protect the active ingredients.

In the ideal case, the active substances must be released from polymeric microcapsules are not in possession of the appropriate drug, and only provided for the manifestation of his actions.

The release of active substances from the microcapsules in the process of applying the containing drugs often occurs as a result of destruction of polymer membranes, caused by mechanical, thermal, chemical or enzymatic action. However, such environmenta is I'm on a polymeric shell, in most cases, have a negative impact on the biological activity of the prisoners in her active substances.

Taking place in accordance with a similar mechanism of release of active ingredients of cosmetic compositions for skin care, especially of drugs intended for the treatment of sensitive, irritated or child's skin, for obvious reasons is problematic or impossible.

In addition, when skin care, special attention should be paid to the absence of possible damage to its Kislitsina layer unsuitable additives, but, on the contrary, to save this layer and keep it alive, that is, to the maximum extent possible to facilitate the observance of the "natural" environment.

The present invention was based on the task to offer drugs with selective affinity to a specific current substance from which it could be released gradually and sparingly only in the place of the action of the drug.

Another objective of the present invention was to provide preparations, the release of the active substance of which would stimulate physiological factors such as contact with the skin or other organs. In other words, the present invention was to facilitate targeted release of the active substance of the drug, and it would Bo the agreement capacity of the skin, respectively of the body, as selective pathogenic factor, showing the effect after applying the drug.

The above problems are solved with the help of a cosmetic or dermatological preparations containing at least one active ingredient, at least one polymer, molecular imprinted in the presence of this active substance, and at least one fatty phase.

Proposed in the invention of the drugs allow for targeted release of hydrophilic, amphiphilic, lipophilic and sensitive to oxidation or hydrolysis of active substances. This applies to all the usual cosmetic and dermatological applications such active substances.

If in the present description we are definitely talking cosmetic active substances, cosmetic products, cosmetic applicability or cosmetic applications and insufficiently specified dermatological equivalents, at the same time necessarily mean and dermatological active agents, dermatological agents, applicability in dermatology and scope dermatological applications.

Molecular imprinting of polymers is a technology that intensively developed in recent years mainly in the areas is cromatografia, solid-phase extraction and processing of sewage.

Detailed information regarding the technology of molecular imprinting polymers described in "Molecular Imprinting - From Fundamentals to Applications", Komiyama and other, Wiley-VCH, ISBN 3-527-30569-6, as well as in ACS Symposium Series 703, "Molecular and Ionic Recognition with imprinted Polymers", Ed. R.A. Bartsch, M. Maeda, ISBN 0-8412-3574-0.

About the technology of molecular imprinting polymers are also known, for example, from the sphere of intelligence agrochemical active substances (see, for example, J. Agric. Food Chem., 1995, 43, 1424-1427, Journal of Physics: Confernece Series, 10(2005) 281-284, J. Agric. Food Chem., 1996, 44, 141-145, as well as Chemistry Letters, 7 (1995), 491-612).

Molecular imprinted polymers are widely used as stationary phases in high performance liquid chromatography (see, for example, Molecular and Ionic Recognition with imprinted Polymers, ACS Symposium Series 703, p.5).

Kanekiyo and others (Angew. Chem. Int. Ed., 2003, 42, 3014-16) consider molecular imprinted polymers (MIP), the affinity of which is to "guest molecules", by which was implemented imprinting depends on pH. As a MIP, the authors used a crosslinked N,N-methylenebisacrylamide polymer-based acryloyl amylose and monomers containing carboxyl groups. As a "guest molecules" used bisphenol-A. found that the ability of such imprinted polymers with carboxyl groups to bind Espanol And decreases with increase in pH.

Demirel and others (Macromol. Biosci., 2005, 5, 1032-37) consider the dependence of the adsorption of bovine serum albumin hydrogels copolymers based on N-tert-butylacrylamide, acrylamide and maleic acid from pH and temperature.

Byrne and others (Advanced Drug Delivery Reviews, 54 (2002), 149-161) describe the application of molecular imprinted hydrogels as gels with controlled release of active ingredient for medicines.

Cunliffe and others (Advanced Drug Delivery Reviews, 57 (2005), 1836-1853) also consider the use of molecular imprinted hydrogels for the release of pharmaceutical active substances.

In European patent application EP-A 925776 described molecular imprinted polymers with the connection points of at least one organoleptic substances. Information about additionally containing a fatty phase of the cosmetic products in the publication no.

The term "at least one active ingredient" means that to obtain a molecular imprinted polymer can be used one, two or more of the following cosmetic active substances, preferably one or two, particularly preferably one cosmetic active ingredient.

Molecular imprinted polymers contain:

a) structural units of the at least one connection with capable to p is liberizatsii a double bond, and

b) structural units of the at least one connection of at least two capable of radical polymerization of non-conjugate double bonds.

In this connection a) is preferably selected from the group including:

A1) capable of radical polymerization, anionic or anionic compounds

A2) esters Ethylenediamine carboxylic acid,

A3) amides Ethylenediamine carboxylic acid,

A4) esters on the basis of vinyl or allyl alcohol and monocarboxylic acids with 1-30 carbon atoms, simple vinyl ethers, vinylacetate, vinylimidazole, vinylaromatic connection, vinylchloride, vinylidenechloride, vinylpyridine, mo norepine with 2-8 carbon atoms and nonaromatic hydrocarbons with at least two conjugated double bonds and

A5) a mixture of the above compounds.

Compounds A1)

It is capable of radical polymerization, anionic or anionic compounds A1) are monomethylethanolamine monocarboxylic and dicarboxylic acids with 3-25 carbon atoms, preferably 3-26 carbon atoms, which can also be used in the form of corresponding salts or anhydrides. Examples of such compounds are acrylic acid, methacrylic acid, etakrinova acid, α-goracinova acid, crotonic Ki the lot, maleic acid, maleic anhydride, taconova acid, Tarakanova acid, musicanova acid, glucagonoma acid, konitova acid and fumaric acid. The compounds A1) are also complex monetary monoethylene-unsaturated dicarboxylic acids with 4 to 10 carbon atoms, preferably 4-6 carbon atoms, such as onomatology ester of maleic acid.

In addition, the compounds A1) are monomethylethanolamine sulfonic acids and phosphonic acids, for example, vinylsulfonate, arylsulfonate, sulfoetaksilat, sulfoaildenafil, sulfopropyl, alphapapillomavirus, 2-hydroxy-3-acrylic-oxypropylation, 2-hydroxy-3-methacryloxypropyl-acid, styrelseledamot, 2-acrylamide-2-methylpropanal-acid, vinylphosphonic acid and allylphosphonate acid.

The compounds A1) also include salts of the above acids, especially salts of sodium, potassium and ammonium, and salts formed by these acids with cosmetically acceptable amines. Compounds A1) can be used individually or as mixtures with each other.

Compound A1) is preferably chosen from the group comprising acrylic acid, methacrylic acid, ethacrylate acid, □α-chloro-acrylic acid, cretonne easy acid, maleic acid, Mal is andnew anhydride, fumaric acid, taconova acid, citraconate acid, metaconule acid, glucagonoma acid, Aconitum acid and mixtures thereof, and particularly preferably used are acrylic acid, methacrylic acid and mixtures thereof, especially methacrylic acid.

Compounds A2)

Compound A2), for example, selected from the group comprising methyl(meth)acrylate, ethyl(meth)acrylate, n-propyl(meth)acrylate, isopropyl(meth)acrylate, n-butyl(meth)acrylate, tert-butyl(meth)acrylate, isobutyl(meth)acrylate, sec-butyl(meth)acrylate, 2-pentyl(meth)acrylate, 3-pentyl(meth)acrylate, isopentyl(meth)acrylate, neopentyl(meth)acrylate, n-octyl(meth)acrylate, 1,1,3,3-TETRAMETHYLBUTYL(meth)acrylate, ethylhexyl(meth)acrylate, n-nonyl-(meth)acrylate, n-decyl(meth)acrylate, n-undecyl(meth)acrylate, tridecyl-(meth)acrylate, myristyl(meth)acrylate, pentadecyl(meth)acrylate, palmityl-(meth)acrylate, heptadecyl(meth)acrylate, monodecyl(meth)acrylate, Arachidyl-(meth)acrylate, behenyl(meth)acrylate, lignocaine(meth)acrylate, carotenal-(meth)acrylate, melissinos(meth)acrylate, palmitoleic(meth)acrylate, oleyl(meth)acrylate, linolyl(meth)acrylate, linolenic(meth)acrylate, stearyl(meth)acrylate, lauryl(meth)acrylate, phenoxyethylacrylate, 4-tert-butylcyclohexylamine, sikorksy(meth)acrylate, ureido(meth)acrylate, tetrahydrofurfuryl(meth)acrylate and mixtures thereof.

Compound A2) preferably using the ANO from the group include esters of (meth)acrylic acid.

Compound A2) is particularly preferably selected from the group including methacrylates and acrylates. Preferred (meth)acrylates include alkyl(meth)acrylates with 1 to 10 carbon atoms in the alkyl and the above all the above alkyl(meth)acrylates with 1 to 4 carbon atoms in the alkyl.

Suitable compounds A2) are also the esters on the basis of α,β-Ethylenediamine monocarboxylic and dicarboxylic acids and aminoalcohols. Thus are preferred aminoalcohols with 2-12 carbon atoms, the nitrogen atom which contains manually or valkiry Deputy with 1-8 carbon atoms in the alkyl. Suitable acid components such esters are, for example, acrylic acid, methacrylic acid, fumaric acid, maleic acid, taconova acid, crotonic acid, maleic anhydride, monobutylether and mixtures thereof. As the acid component, it is preferable to use acrylic acid, methacrylic acid and mixtures thereof.

Preferred monomers A2) are N-tert-butylamino-ethyl(meth)acrylate, N,N-dimethylaminomethyl(meth)acrylate, N,N-dimethyl-amino-ethyl(meth)acrylate, N,N-diethylaminoethyl(meth)acrylate, N,N-dimethyl-aminopropyl(meth)acrylate, N,N-diethylaminopropyl(meth)acrylate and N,N-dimethylaminoethoxy(meth)acrylate. This item is the preferred monomers A2) are N-tert-butylaminoethyl(meth)acrylate and N,N-dimethylaminoethyl(meth)acrylate.

Suitable compounds A2) are also the esters on the basis of α,β-Ethylenediamine monocarboxylic and dicarboxylic acids and diols, such as 2-hydroxyethylacrylate, 2-hydroxyethylmethacrylate, 2-hydroxyethylacrylate, 2-hydroxypropylmethacrylate, 2-hydroxyprop-permeabilit, 3-hydroxypropylamino, 3-hydroxypropylmethacrylate, 3-hydroxyethylacrylate, 3-hydroxyethylmethacrylate, 4-hydroxybutyl-acrylate, 4-hydroxyethylmethacrylate, 6-hydroxyhexyloxy, 6-hydroxypaclitaxel, 3-hydroxy-2-ethyl hexyl acrylate and 3-hydroxy-2-ethylhexylacrylate.

Compound A3)

Compound A3) preferably can be selected from the group comprising amide of acrylic acid amide and methacrylic acid, N-methyl(meth)acrylamide, N-ethyl(meth)acrylamide, N-propyl(meth)acrylamide, N-(n-butyl)(meth)acrylamide, N-(tert-butyl)(meth)acrylamide, N,N-dimethyl-(meth)acrylamide, N,N-diethyl(meth)acrylamide, piperidinyl(meth)acrylamide, morpholinyl(meth)acrylamide, N-(n-octyl)(meth)acrylamide, N-(1,1,3,3-Tetra-methylbutyl)(meth)acrylamide, N-ethylhexyl(meth)acrylamide, N-(n-nonyl)-(meth)acrylamide, N-(n-decyl)(meth)acrylamide, N-(n-undecyl)(meth)acryl-amide, N-tridecyl(meth)acrylamide, N-myristyl(meth)acrylamide, N-Penta-decyl(meth)acrylamide, N-palmityl(meth)acrylamide, N-heptadecyl(meth)-acrylamide, N-nandell(meth)acrylamide, N-Arachidyl(meth)acrylamide, N-behenyl(meth)acrylamide, N-ignorerer(meth)acrylamide, N-carotenal-(meth)acrylamide, N-melissinos(meth)-acrylamide, N-palmitoleic(meth)-acrylamide, N-oleyl(meth)acrylamide, N-linoleyl(meth)acrylamide, N-linoleyl(meth)acrylamide, N-stearyl(meth)acrylamide and N-lauryl(meth)-acrylamide.

Suitable monomers A3) are also the amides on the basis of the abovementioned α,β-Ethylenediamine monocarboxylic and dicarboxylic acids and diamines which contain at least one primary or secondary amino group. Preferred are the diamines containing one tertiary and one primary or secondary amino group.

Suitable monomers A3) are, for example, N-tert-butyl-amino-ethyl(meth)acrylamide, N-[2-(dimethylamino)ethyl]acrylamide, N-[2-(dimethylamino)ethyl]methacrylamide, N-[3-(dimethylamino)propyl]acryl-amide, N-[3-(dimethylamino)propyl]methacrylamide, N-[4-(dimethylamino)-butyl]acrylamide, N-[4-(dimethylamino)butyl]methacrylamide, N-[2-(diethyl-amino)ethyl]acrylamide, N-[4-(dimethylamino)cyclohexyl]acrylamide and N-[4-(dimethylamino)cyclohexyl]methacrylamide.

Suitable monomers A3) are also hydroxyalkylated the above α,β-Ethylenediamine monocarboxylic and dicarboxylic acids, such as 2-hydroxyethylacrylate, 2-hydroxyethyl-methacrylamide, 2-hydroxyethylmethacrylate, 2-hydroxypropylamino, 2-hydroxypropylmethacrylamide, 3-hydroxypropylmethacrylamide, 3-hydroxy-propylate Grilamid, 3-hydroxyethylacrylate, 3-hydroxybutyl-acrylamide, 4-hydroxyethylacrylate, 4-hydroxyethylmethacrylate, 6-hydroxyacetanilide, 6-hydroxyhexadecanoic, 3-hydroxy-2-ethylhexylacrylate and 3-hydroxy-2-ethylhexylacrylate.

Compound A4)

Suitable compounds A4) are, for example, N-vinylacetate and their derivatives, which may contain, for example, one or more alkyl substituents with 1 to 6 carbon atoms, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, and so forth. Suitable compounds A4) include, for example, N-vinyl pyrrolidone, N-vinylpyridine, N-vinylcaprolactam, N-vinyl-5-methyl-2-pyrrolidone, N-vinyl-5-ethyl-2-pyrrolidone, N-vinyl-6-methyl-2-piperidone, N-vinyl-6-ethyl-2-piperidone, N-vinyl-7-methyl-2-caprolactam and N-vinyl-7-ethyl-2-caprolactam. Particularly preferably used N-vinyl pyrrolidone and/or N-vinylcaprolactam.

Suitable compounds A4) are, for example, N-vinylimidazole General formula (II):

,

in which the residues R5-R7independently of one another denote hydrogen, alkyl with 1-4 carbon atoms or phenyl.

Examples of compounds of General formula (II) shown in table 1.

tr>
Table 1
R 5R6R7
NNN
MeNN
NMeN
NNMe
MeMeN
NMeMe
MeNMe
PhNN
NPhN
NNPh
PhMeN
PhNMe
MePhN
NPhMe
NMePh
MeNPh
Me means methyl,
Ph means phenyl

As the monomer A4) preferably using 1-vinylimidazole (N-vinylimidazole).

Connection b)

Compounds (b) contain at least two capable of radical polymerization of non-conjugate double bonds. These compounds are usually in the following description, also referred to as cross-linking agents.

Suitable compounds b) are, for example, esters of acrylic acid, esters of methacrylic acid, simple apologia esters or simple vinyl ethers of at least diatomic alcohols alcohols. The hydroxyl group of the corresponding diatomic alcohols can be converted into a group of simple or complex esters of partially or fully, however, the crosslinking agents contain at least two Ethylenediamine group.

Examples underlying the esters of diatomic alcohols are 1,2-ethanediol, 1,2-propandiol, 1,3-propandiol, 1,2-butanediol, 1,3-butanediol, 2,3-butanediol, 1,4-butanediol, but-2-ene-1,4-diol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, 1,10-d is the Kahn-diol, 1,2-dodecanediol, 1,12-dodecanediol, neopentylglycol, 3-methyl-pentane-1,5-diol, 2,5-dimethyl-1,3-hexanediol, 2,2,4-trimethyl-1,3-pentane-diol, 1,2-cyclohexanediol, 1,4-cyclohexanediol, 1,4-bis(hydroxymethyl)cyclohexane, complex monoether based hydroxypivalic acid and neopentyl glycol, 2,2-bis(4-hydroxyphenyl)propane, 2,2-bis[4-(2-hydroxypropyl)phenyl]propane, diethylene glycol, triethylene glycol, tetraethylene glycol, dipropyleneglycol, tripropyleneglycol, tetrapropyl-lepicol, 3-thiopental-1,5-diol, and polyethylene glycols, polypro-pelagically and polytetrahydrofurans with molecular weight respectively from 200 to 10000. In addition to the homopolymers of ethylene oxide, of propylene oxide, respectively, is also possible to use block copolymers of ethylene oxide or propylene oxide or copolymers containing structural units of ethylene oxide and propylene oxide. Examples underlying the esters of alcohols containing more than two hydroxyl groups, are trimethylolpropane, glycerol, pentaerythritol, 1,2,5-pentandiol, 1,2,6-hexanetriol, triethoxysilane acid, sorbitan, and sugars such as sucrose, glucose and mannose. Polyhydric alcohols, obviously, can also be used after their interaction with ethylene oxide or propylene oxide in the form of corresponding ethoxylates, respectively, of propoxylation. By communicating what epichlorohydrin polyhydric alcohols can also first be converted into a corresponding glycidyloxy esters. Preferred are etilenglikoli(meth)acrylate, polietilenglikoli(meth)acrylates.

Other suitable compounds b) are complex vinyl ethers or esters based on unsaturated monohydroxy alcohols and Ethylenediamine carboxylic acid with 3-6 carbon atoms, for example, acrylic acid, methacrylic acid, basis of itaconic acid, maleic acid or fumaric acid. Examples of these alcohols are allyl alcohol, 1-butene-3-ol, 5-HEXEN-1-ol, 1-octene-3-ol, 9-mission-1-ol, dicyclopentadienyl alcohol, 10-undecen-1-ol, cinnamic alcohol, citronellol, krotilova alcohol or CIS-9-octadecene-1-ol. Unsaturated monohydroxy alcohols can also be acerifolia-Vanir polybasic carboxylic acids such as malonic, tartaric, trimellitic, phthalic, terephthalic, citric or succinic acid.

Other suitable crosslinking agents are the esters on the basis of unsaturated carboxylic acids, for example oleic acid, cretonne easy acid, cinnamic acid or 10-undecenoic acid, and the above polyhydric alcohols.

Suitable crosslinking agents are also unbranched, branched or cyclic aliphatic or aromatic hydrocarbons with at least two double bonds, which in the case of aliphatic hydrocarbons is not up to what must be paired, for example, divinylbenzene, dividercolor, 1,7-octadiene, 1,9-decadiene, 4-vinyl-1-cyclohexene, trivinylcyclohexane or polybutadienes with molecular weight from 200 to 20000.

Suitable crosslinking agents (f) are also the amides of acrylic acid, amides of methacrylic acid and N-allylamine on the basis of at least bifunctional amines such amines include, for example, 1,2-diaminoethane, 1,2-diaminoethane, 1,3-diaminopropane, 1,4-diaminobutane, 1,6-diaminohexane, 1,12-dodecandioic, piperazine, Diethylenetriamine or ISOPHORONEDIAMINE. Suitable amides are also based on allylamine and unsaturated carboxylic acids, such as acrylic, methacrylic, taconova or maleic acid, or at least dibasic carboxylic acids, such as described above.

Furthermore, as cross-linking agents b) suitable triallylamine and salts of Triethylenetetramine, for example, chloride or methyl sulfate of triethylmethylammonium.

Suitable crosslinking agents (b) are also N-vinyl compounds of urea derivatives, at least bifunctional amides, cyanurates or urethanes, for example, urea, atlantabased, propylenecarbonate or diamide tartaric acid, such as N,N'-diphenylethylenediamine or N,N'-diphenylpropylamine.

Other suitable compounds b) are divinities is h, tetraallylsilane or tetraphenylsilane.

Obviously, you can also use mixtures of the above compounds (b).

As compounds b) is more preferably used, etilenglikoli(meth)acrylate, polietilenglikoli(meth)acrylates, complex trailerby ether of pentaerythritol, methylenebisacrylamide, N,N'-diphenylethylenediamine, triallylamine, trimethylolpropane(meth)acrylate and salts of Triethylenetetramine.

The molar ratio of compounds a) to the compound (b) generally is in the range from 1:2 to 1:10, preferably from 1:2 to 1:4, more preferably from 1:2.5 to 1:3.5 and above all from 1:2.8 to 1:3,2.

Proposed in the invention, the polymers are synthesized by polymerization of deposition of the polymer is carried out in a periodic or properities mode in the presence of the active substance (a template) and a significant excess solvent, the mass ratio of which to the existing substance is in the range from 100:1 to 5:1, preferably from 100:1 to 50:1, particularly preferably 59:1. The particles of the resulting polymer was purified by extraction in to conventional Soxhlet extractions. Once the current attachment point of the active substance to the polymer (molecular imprints) will again be filled by the template (or in case of refusal from the extraction of the template upon completion of the synthesis of the polymer), the polymer can be used for controlled, accordingly delayed release of the cosmetic active substance.

Proposed in the invention, the preparations are characterized in that the rate of release of active substance from a complex polymer - active substance at above pH 5 than at pH 7.

The complex polymer - active substance is formed when the first was done typing the active substance in the polymer, and then removing unattached thereto of the active substance, respectively, if the previously imprinted attached and released from the active substance, the polymer is again saturated reactant.

Under the rate of release of one or another active substance mean amount of active ingredient released per unit time from the complex polymer-active substance (the rate of release indicate, for example, in µg/min).

The rate of release of active substance is determined as follows. The cell to ultrafiltrable fill with a variance of 100 mg of molecular imprinted polymer in 100 ml of water with adjusted pH), which is the purpose of homogenization is stirred for 15 minutes. Through a peristaltic pump into the cell from the collector through the inlet fitting impose extractant (water with the same pH). Coming from a cell extract towards Aut to the back side of the cell into the receiving vessel. The duration of the experiment is 12 hours, and the replacement of the receiving vessel is produced every 60 minutes, and, consequently, in the course of the experiment accumulate twelve fractions. Determine the volume, mass, and duration of selection of individual fractions and each fraction of the selected sample volume of 2 ml Samples are passed through a filter of 0.45 μl)is injected into injection vials and used for determination of tocopherol by high performance liquid chromatography (HPLC).

The object of the present invention is also a method of obtaining a molecular imprinted polymer, wherein the polymer is produced by polymerization deposition carried out in the presence of the active substance.

The basic principle of polymerisation deposition of polymer known in the art and described, for example, Guyot A. (1989), Comprehensive Polymer Science, volume 4, G.C. Eastmond, A. Ledwith, S. Russo, and P. Sigwalt (Eds.)., Oxford: Pergamon, c.261-273.

In a preferred embodiment of the invention the molecular imprinted polymer can be obtained in the following way:

(a) at least one compound a) is mixed with at least one active substance in a suitable solvent, add at least one compound b) and initiate polymerization, and pre-compound b) is preferably dissolved in a solvent, to the verge in an even more preferred variant of the same solvent, in which the dissolved compound a), or

(b) at least one compound a) is mixed in a suitable solvent at least one active ingredient and at least one compound b) and then initiate the polymerization.

Polymerization can proceed by radical, anionic, cationic or coordination mechanism or it can be implemented in accordance with the principle of polycondensation or polyaddition. The polymerization is preferably implemented in accordance with a radical mechanism. You can use various initiators and/or catalysts and, if necessary, to bring the heat.

For cationic polymerization can be used, for example, the following initiators:

protonic acid, Lewis acid, together or without sonication, ions Carbonia, ions iodone and/or ionizing radiation.

For anionic polymerization can be used, the following initiators: Foundation, Foundation Lewis, ORGANOMETALLIC compounds and/or vectors of the electrons, for example, alkali metals, the complex of alkali metals with aromatic compounds or metallteile.

For coordination polymerization can be used, the following initiators/catalysts:

mixed ORGANOMETALLIC catalysts (catalysts of the Ziegler-Natta), π-complexes go is the breaking of metals, for example, metallocene and/or activated oxides of transition metals.

Initiators suitable for implementing the preferred radical polymerization are, for example, peroxides or azo-compounds, substituted atany (for example, benzopinacol), a redox system consisting of inorganic and organic components, heat, UV rays and other high energy radiation, hydroperoxides, percolate and persulfates, such as peroxodisulfate potassium and the preferred initiators are azo compounds.

Suitable azo compounds are 2,2'-azobisisobutyronitrile, 2,2'-azobis(2-methylbutyronitrile), 2,2'-azobis(2,4-dimethylvaleronitrile), 2,2'-azobis(4-methoxy-2,4-dimethylvaleronitrile), 1,1'-azobis(1-cyclohexane-carbonitrile), 2,2'-azobis(isobutyramide) dihydrate, 2-phenylazo-2,4-dimethyl-4-methoxyvaleronitrile, dimethyl-2,2'-azobisisobutyronitril, 2-(carbamoylation)isobutyronitrile, 2,2'-azobis(2,4,4-trimethylpentane), 2,2'azobis(2-methylpropane), 2,2'-azobis(N,N'-dimethylaminopyridine) in the form of free base or hydrochloride, 2,2'-azobis(2-amidinopropane) in the form of free base or hydrochloride, 2,2'-azobis(2-methyl-N-[1,1-bis(hydroxymethyl)ethyl]propionamide or 2,2'-azobis(2-methyl-N-[1,1-bis(hydroxymethyl)-2-hydroxyethyl]propionamide.

Suitable peroxides are, is, for example, peroxide acetylthio-hexanesulfonate, diisopropylperoxydicarbonate, tert-milper-neodecanoate, tert-butylperbenzoate, tert-butylacetat, tamilbeat, peroxide, bis(2,4-dichlorobenzoyl acid), peroxide visitnorway acid, peroxide diisodecyl acid, peroxide dioctanoyl acid, peroxide gilaurili acid, peroxide, bis(2-methylbenzoic acid), peroxide dinternal acid, diacetyl peroxide, peroxide by Dibenzoyl acid, tert-Builder-2-ethylhexan-neat, peroxide, bis(4-chlorbenzoyl acid), tert-butylperbenzoate, tert-butylparaben, 1,1-bis(tert-BUTYLPEROXY)-3,5,5-trimethyl-cyclohexane, 1,1-bis(tert-BUTYLPEROXY)cyclohexane, tert-Builder-axisoperation, tert-butylperbenzoate, tert-Builder-acetate, tert-eilperindoes, mpem-butylperbenzoate, 2,2-bis(tert-BUTYLPEROXY)butane, 2,2-bis-10-(tert-BUTYLPEROXY)propane, peroxide, di -, has been studied, 2.5-dimethylhexane-2,5-di-tert-butylperoxide, 3-tert-butyl-peroxy-3-phenolphthalein, di-tert-AMYLPEROXY, α,α'-bis(tert-butyl-phenoxyisopropyl)benzene, 3,5-bis(tert-BUTYLPEROXY)3,5-dimethyl-1,2-dioxolane, di-tert-butylperoxide, 2,5-dimethylhexane-2,5-di-tert-butylperoxide, 3,3,6,6,9,9-HEXAMETHYL-1,2,4,5-tetraacetylurea, hydro-peroxide p-Mentana, the hydroperoxide of Pinna, monohydroperoxide diiso-propylbenzene, the hydroperoxide cumene or tert-botiller the peroxide.

A crosslinking agent, depending on its physical state can be introduced in the reaction mixture in solid or liquid form, and dissolved in the solvent or dispergirovannom (that is, emulsified or suspended form, preferably in dissolved form. In the reaction mixture is preferably injected liquid crosslinking agent or a crosslinking agent, dissolved (or dispersed/mixed in the solvent, particularly preferably dissolved (or dispersed/mixed in the solvent, a crosslinking agent. In an even more preferred embodiment, a crosslinking agent dissolved in the same solvent and a functional monomer or a crosslinking agent.

As a solvent it is possible to use organic solvents, such as dimethylformamide, ethanol, methanol, isopropanol, chloroform, dichloromethane, toluene, dimethyl sulfoxide, hexane or acetonitrile, preferably toluene or acetonitrile. In addition, you can use a mixture of these solvents.

In another embodiment, the solvent or mixtures of solvents can add up to 50 wt%. water.

Depending on the solvent polymerization, as a rule, carried out at a temperature from 40 to 120°C.

The polymer particles obtained in accordance with all the above variants of the invention, below crescendo indicate MIP.

The resulting polymerization particles can be directly used in medicines or to combine them with supporting prescription components and construction of a suitable composition.

Another object of the present invention is the use of molecular imprinted polymers in cosmetic preparations, especially in cosmetic preparations for the hair.

Another object of the present invention is a method of treatment of keratin surfaces, characterized in that the implement contact keratin surface with a molecular imprinted polymer.

Active ingredients

Proposed in the invention, the preparations contain cosmetically acceptable active substances Such active substances intentionally released from their combination with molecular imprinted polymer, especially in the pH range 5 to 7.

According to the invention the active ingredients (one or more compounds) can preferably be selected from the group comprising acetylsalicylic acid, atropine, azulene, hydrocortisone and its derivatives, e.g. hydrocortisone-17-valerate, vitamins of groups b and D, especially vitamin B1, vitamin B12, vitamin D, vitamin a and corresponding derivatives, such as retinyl palmitate, vitamin E and its derivatives, such as Toko is aryl acetate, vitamin C and its derivatives, such as ascorbicacid and nicotinamide, panthenol, bisabolol, polidocanol, unsaturated fatty acids such as essential fatty acids (commonly called vitamin F), first of all γ-linolenic acid, oleic acid, eykozapentaenovuyu acid, docosahexaenoyl acid and their derivatives, levomycetin, caffeine, prostaglandins, thymol, camphor, squalene, extracts and other products of vegetable and animal origin, e.g. evening primrose oil, borage oil or black currant oil, fish fats, health fish oil, ceramides and similar compounds, frankincense extract, green tea extract, extract of Lily white, licorice, witch hazel, antiseborrheic active substances (for example, selenium disulfide, sincerity, piroctone, alamin, climbazol, octopirox, polidocanol and their combinations), complex active ingredients, including, for example, γ-oryzanol and calcium salts, such as calcium Pantothenate, calcium chloride and calcium acetate.

The active substance or active substances, first of all, if proposed in the invention are preparations for the treatment and prevention of the symptoms of aging, caused by the internal state of the organism and/or the influence of external factors, as well as for treatment and preventive care is IKI harmful effects on the skin and hair of ultraviolet radiation, can also be selected from the group comprising inhibitors of NO-synthase. A preferred inhibitor of NO-synthase is nitroarginine.

In addition, the active substances are preferably selected from the group including catechins, esters on the basis of Gallic acid and catechins and aqueous or organic extracts from plants or parts of plants, containing catechins or esters of Gallic acid and catechins, such as leaves of plants in the family Theaceae, first of all, Camellia sinensis (green tea). It is particularly preferred active substances are typical ingredients of these extracts (e.g., polyphenols, respectively catechins, caffeine, vitamins, sugars, minerals, amino acids and lipids).

Catechins are a group of compounds that can be considered as hydrogenated flavones or anthocyanidins and which are derivatives of catechin (catechol, 3,3',4',5,7-flavan-pentola, 2-(3,4-dihydroxyphenyl)chroman-3,5,7-triol). In accordance with the present invention the preferred active ingredient is also epicatechin [(2R,3R)-3,3',4',5,7-flowerpetal].

Preferred are also contains catechins, plant extracts, especially the green tea extracts, such as extracts from leaves of plants of the species Camellia spec., in the osobennosti teas Camellia sinenis, .assamica, .taliensis or .inawadiensis and related hybrids, for example, Japanese Camellia (Camellia japonica).

In addition, the preferred active substances are polyphenols, respectively catechins selected from the group comprising (-)-catechin, (+)-catechin, (-)-catechingallat, (-)-gallocatechin-gallate, (+)-epicatechin, (-)-epicatechin, (-)-epicatechol, (-)-epigallo-catechin and (-)-epigallocatechingallate.

In addition, in accordance with the present invention the preferred active substances are flavone and its derivatives (often also called "flavones"). They have the following basic structure (with indication of the position of deputies):

.

Table 2 shows some of the more important flavones, which preferably can also be used in the proposed invention the drugs.

Table 2
Flavones
The position of the hydroxyl substituents
35782' 3"4'5'
Flavon--------
Flavonol+-------
Chrisen-++-----
Galangin+++-----
Apigenin-++-- -+-
Fisetin+-+--++-
The position of the hydroxyl substituents
35782'3'4'5'
Luteolin-++--++-
Kemperol+++---+-
Quercetin+ ++--++-
Maureen+++-+-+-
Robinets+-+--+++
Gossipteen++++-++-
Myricetin+++--+++

In nature, flavones, usually found in glucosideuronic f is RME.

According to the invention, the flavonoids are preferably chosen from the group comprising compounds of General formula:

in which Z1-Z7mean substituents, independently from each other selected from the group comprising hydrogen, hydroxyl group, alkoxy, hydroxyalkoxy can be branched and unbranched and can contain 1-18 carbon atoms, means Gly residue selected from the group comprising monoglycoside and oligoglycosides remains.

According to the invention, the flavonoids are preferably can be selected from the group comprising compounds of General formula:

,

in which Z1-Z6mean residues, independently from each other selected from the group comprising hydrogen, hydroxyl group, alkoxy and hydroxy, alkoxy, can be branched and unbranched and can contain 1-18 carbon atoms, and means Gly residue selected from the group comprising monoglycoside and oligoglycosides remains.

Compounds of the above structures can preferably selected from the group including flavonoids General formula:

,

in which Z1-Z6independently from each other, such as described above, a Gly1, Gly2and Gly3independently from each other mean manglik sidnie or oligoglycosides residues. Residues Gly2accordingly Gly3individually or together can also be saturated by hydrogen atoms groups.

Residues Gly1, Gly2and Gly3independently from each other preferably selected from the group including hexosamine remains primarily rhamnosyl and glucosyl. If necessary, preferably possible to use also found in Ginkgo with other hexosamine residues, for example, allusion, altrusim, galactosyl, gulselam, edosian, manasellam and talasila.

According to the invention can preferably be used are also found in Ginkgo with pentosidine remains.

The substituents Z1-Z5independently from each other preferably selected from the group comprising hydrogen, hydroxyl group, methoxy, ethoxy and 2 hydroxyethoxy, and the corresponding found in Ginkgo have the General structural formula:

Particularly preferably found in Ginkgo are selected from the group of compounds having the following General formula:

in which Gly1, Gly2and Cly3independently from each other mean monoglycoside or oligoglycosides residues. Residues Gly2accordingly Gly3individually or together can also be saturated atoms is hydrogen groups.

Residues Gly1, Gly2and Gly3independently from each other preferably selected from the group including hexosamine remains primarily rhamnosyl and glucosyl. If necessary, preferably possible to use also found in Ginkgo with other hexosamine residues, for example, allusion, altrusim, galactosyl, gulselam, edosian, manasellam and talasila.

According to the invention preferred may be the use of found in Ginkgo with pentosidine remains.

In accordance with the present invention particularly preferred are found in Ginkgo selected from the group comprising α-glucosylrutin, α-glucosylrutin, α-glucosaminechondroitin, α-glucoseregulated and α-glucosylrutin.

Other preferred active substances are seriesid, pyridoxal, vitamin K, Biotin and aromatic substances.

Along with these active ingredients (one or more compounds), even more preferably may be selected from the group primarily includes the following hydrophilic connection:

α-hydroxy acid such as lactic or salicylic acid, respectively, and their salts, such as sodium lactate, calcium lactate, lachat triethanolamine, urea, allantoin, serine, sorbitol, glycerin, milk proteins, panthenol and hits the N.

In addition, in a particularly preferred variant of the invention, the active ingredients (one or more compounds) can also be selected from the group comprising Sitophilus agents.

Suitable Sitophilus agents are substances that absorb UV rays in the UV-b and/or UV-a region of the spectrum. These organic substances are able to absorb ultraviolet rays and return the absorbed energy in the form of long-wave radiation, for example, in the form of heat. Organic matter can be oil-soluble or water-soluble. Suitable UV filters are, for example, 2,4,6-Triaryl-1,3,5 - triazine, aryl group which may contain at least one Deputy, preferably selected from the group comprising hydroxy, alkoxy, in particular methoxy, and alkoxycarbonyl, in particular, methoxycarbonyl or etoxycarbonyl. Suitable UV filters are also esters of p-aminobenzoic acid, esters of cinnamic acid, benzophenone, camphor derivatives, as well as inhibiting UV rays pigments, such as titanium dioxide, talc and zinc oxide. Especially preferred are pigments based on titanium dioxide.

As oil-soluble UV-b filters can be used, for example, the following substances:

3-benzylideneamino and its derivatives, for example, 3-(4-methylbenzylidene)camphor,

derivatives of 4-aminobenzoic acid, preferably 2-ethylhexyloxy ester of 4-(dimethylamino)benzoic acid, 2-oktilovom ester of 4-(dimethylamino)benzoic acid amyl ester of 4-(dimethylamino)-benzoic acid,

esters of cinnamic acid, preferably 2-ethylhexyloxy ether 4-methoxycatechol acid, propyl ester 4-methoxycatechol acid, isoamyl ester 4-methoxycatechol acid, isopentylamine ether 4-methoxycatechol acid and 2-ethylhexyloxy ester 2-cyano-3-phenylcarbinol acid (octocrylene),

esters of salicylic acid, preferably 2-ethylhexyloxy, 4-isopropylbenzylamine or momenteraly ester of salicylic acid,

derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzo-none, 2-hydroxy-4-methoxy-4'-methylbenzophenone and 2,2'-dihydroxy-4-methoxybenzophenone,

esters of benzylmalonate acid, preferably di-2-ethylhexylamine ether 4-methoxybenzylamine acid,

derivatives of triazine, such as 2,4,6-trainline-(p-Carbo-2'-ethyl-1'-hexyloxy)-1,3,5-triazine (ochiltree), dioctyl butamide treason (Uvasorb®HEB)

propane-1,3-diones, such as 1-(4-tert-butylphenyl)-3-(4'-methoxyphenyl)propane-1,3-dione.

As water-soluble substances can be is to use the following connections:

2-phenylbenzimidazol-5-acid and its salts with alkali or alkaline earth metals, and ammonium salts of alkylamine, alkanolamine and glucamine,

sulfoxylate derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone-5-acid and its salt,

sulfonylurea derivatives of 3-benzylideneacetone, such CAC-(2-oxo-3-barelydigital)benzosulfimide, 2-methyl-5-(2-oxo-3-borrelidin)acid and the corresponding salt.

Especially preferred is the use of esters of cinnamic acid, preferably 2-ethylhexanol ether 4-methoxy-cinnamic acid, isopentanol ether 4-methoxycatechol acid and 2-ethylhexanol ester 2-cyano-3-phenylcarbinol acid (octocrylene).

In addition, it is preferable to use benzophenone derivatives, especially 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone or 2,2'-dihydroxy-4-methoxybenzophenone and propane-1,3-diones, such as 1-(4-tert-butylphenyl)-3-(4'methoxyphenyl)propane-1,3-dione.

Typical suitable UV-a filters are:

derivatives benzoylamino, such as 1-(4'-tert-butyl-phenyl)-3-(4'-methoxyphenyl)propane-1,3-dione, 4-tert-butyl-4'-methoxide-benzoylmethyl or 1-phenyl-3-(4'-isopropylphenyl)propane-1,3-dione,

aminohydrocinnamic the military derivatives of benzophenone, for example, such as N,N-Diethylaminoethanol-n-hexylbenzoate.

Obviously, you can also use a mixture of UV-a and UV-b filters.

Other suitable UV filter substances are given in table 3.

Table 3
Suitable light protection agents
RoomSubstanceRegistration number in Chemical Abstracts (acid)
14-Aminobenzoic acid150-130
23-(4'-Ammonium)benzylideneamino-2-he-methyl sulfate52793-97-2
33,3,5-Trimethylcyclohexylamine(homosalate)118-56-9
42-Hydroxy-4-methoxybenzophenone (oxybenzone)131-57-7
52-Phenylbenzimidazol-5-acid and salts of potassium, sodium and triethanolamine27503-81-7
63,3'-(1,4-phenylendiamine)bis(7,7-dimethyl-2-oxo-bicyclo[2.2.1]heptane-1-methanesulfonate) and its salts90457-82-2
7Complex polyethoxyethanol ether 4-bis(poly-ethoxy)aminobenzoic acid113010-52-9
8Complex 2-ethylhexyloxy ether 4-dimethylamino-benzoic acid21245-02-3
9Complex 2-ethylhexyloxy ester of salicylic acid118-60-5
10Complex 2-isoamyl ether 4-methoxycatechol acid71617-10-2
11Complex 2-ethylhexyloxy ether 4-methoxycatechol acid5466-77-3
122-Hydroxy-4-methoxybenzophenone-5-acid (sulisobenzone) and its sodium salt4065-45-6
133-(4'-Sulfonanilide)Bornand-2-he and its salts5803-58-6
143-Benzylideneamino-2-he16087-24-8
151-(4'-Isopropylphenyl)-3-phenylpropane-1,3-dione63260-25-9
164 Isopropylbenzylamine94134-93-7
173-Imidazol-4-Lacrimosa acid and its complex ethyl ester104-98-3
18Complex ethyl ester of 2-cyano-S-diphenylene-ash acid5232-99-5
19Complex 2'-ethylhexyloxy ester 2-cyano-S-diphenylacetone acid6197-30-4
20Menthyl-o-aminobenzoate or 5-methyl-2-(1-methyl-ethyl)-2-aminobenzoate134-09-8
21Glyceryl-p-aminobenzoate or complex 1-glyceri-levy ester of 4-aminobenzoic acid136-44-7
222,2'-D is hydroxy-4-methoxybenzophenone (dioxime zones) 131-53-3
232-Hydroxy-4-methoxy-4-methylbenzophenone (Mex-non)1641-17-4
24Triethanolaminato2174-16-5
25Dimethoxyphenylacetic acid or 3,4-dimethoxyphenylacetone sodium4732-70-1
263-(4'-Sulfonanilide)Bornand-2-he and its salts56039-58-8
274-Tert-butyl-4'-methoxydibenzoylmethane70356-09-1
282,2',4,4'-Tetrahydroxybenzophenone131-55-5

RoomSubstanceRegistration number in Chemical Abstracts (acid)
292,2'-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-TETRAMETHYLBUTYL)phenol]103597-45-1
302,2'-(1,4-Phenylene)bis-1H-benzimidazole-4,6-disulfonate, sodium salt180898-3-7
312,4-Bis[4-(2-ethylhexyloxy)-2-hydroxy]phenyl-6-(4-methoxyphenyl)-(1,3,5)-triazine187393-00-6
323-(4-Methylbenzylidene)camphor36861-47-9
33Complex polyethoxyethanol ether 4-bis(Polito-XI)-p-aminobenzoic acid113010-52-9
342,4-Dihydroxybenzophenone131-56-6
352,2'-Dihydroxy-4,4'-dimethoxybenzophenone-5,5'-distribulion3121-60-6
36Complex hexyl ester of 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid302776-68-7
372-(2H-Benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]DISI-laksani]propyl]phenol155633-54-8
381,1-[(2,2'-DIMETHYLPROPANE)carbonyl]-4,4-diphenyl-1,3-Boo is alien 363602-15-7

In addition to the above two groups of primary light protection substances is also possible to use secondary light protection agents of a type of antioxidant that is able to break the chain of photochemical reactions occurring during the penetration of UV radiation into the skin. Their typical examples are superoxide dismutase, catalase, tocopherol (vitamin E) and ascorbic acid (vitamin C).

The other group consists protivovazdushna substances that have anti-inflammatory effect on UV damaged skin.

Such substances include, for example, bisabolol, phytyl side-chain and phytantriol.

The list of active substances, according to their combinations, which can be used in the proposed in the invention compositions, of course, has no limits. The active substances can be used individually and in any combination with each other.

According to the invention, the number of such active ingredients (one or more compounds) in the composition is preferably 0.001 to 30 wt. -%, particularly preferably from 0.05 to 20 wt. -%, first of all, from 1 to 10% of the mass. in terms of the total weight of the composition.

The above and other active substances that can be used in the proposed in the invention compositions, see pages 12-17 describes the I German patent application DE 10318526 A1, which in full should be considered an appropriate reference.

The mass ratio of the molecular imprinted the active ingredient of the polymer to the current matter in the proposed invention the preparations is in the range from 1:10 to 100:1, preferably from 1:1 to 10:1, particularly preferably from 4:1 to 5:1 first and foremost is 4:1.

The fatty phase

Proposed in the invention, the preparations comprise at least one fatty phase. Under the fat phase imply any cosmetically acceptable oil, grease and/or wax.

The ingredients of the invention in cosmetic compositions.

The ingredients of cosmetic products preferably selected from the group of substances including natural or synthetic polymers, pigments, stabilizers, moisture, oils, waxes, enzymes, minerals, vitamins, sunscreen agents, dyes, fragrances, antioxidants, preservatives and/or pharmaceutical active substance.

Suitable auxiliary substances and additives used for the preparation of cosmetic preparations for skin care, known in the art and are described in cosmetics handbooks, for example, in Schrader, Grundlagen und Rezepturen der Kosmetika, Huthig Verlag, Heidelberg, 1989, ISBN 3-7785-1491-1, and Umbach, Kosmetik. Entwicklung, Herstellung und application kosmetischer Mittel, 2nd revised edition, 195, Georg Thieme, ISBN 3137126029.

Proposed in the invention of molecular imprinted active ingredient polymers used in the field of dermocosmetics preferably in combination with at least one component selected from the group comprising cosmetically active ingredients, emulsifiers, surface-active substances (surfactants, preservatives, perfume oils, thickeners, polymers, hair conditioners for hair and skin, grafted copolymers, water-soluble or dispersible silicone polymers, light protection agents, bleaches, gelation agents, care agents, coloring tools, tonal resources, tools to simulate tanning, dyes, pigments, consistency regulators, stabilizers, humidity, tool to restore fat, collagen, protein hydrolyzates, lipids, Antioch-Sidency, defoamers, antistatic agents, softeners and plasticizers.

The antioxidants are preferably chosen from the group including amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and derivatives thereof, imidazoles (for example, brokenyou acid) and their derivatives, peptides such as D,L-carnosine, D-carnosine, L-carnosine and derivatives thereof (for example, anserine), carotenoids, carotenes (e.g. β-carotene, lycopene) and derivatives thereof, chlorogenic acid and its derivatives lipanova acid and its derivatives (for example, dihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols (for example, thioredoxin, glutathione, cysteine, cystine, tsistamin and their glycosylase, N-acetylene, methyl, ethyl, propyl, amyl, butyl, lauric, politologie, aerovee, γ-linalilovy, cholesterolemia and glyceriae esters)and their salts, delayintolerant, distearyldimethylammonium, thiodipropionic acid and its derivatives (esters, ethers, peptides, lipids, nucleotides, of the nucleus-side and salt), as well as connections sulfoximine (for example, buthionine-sulfoximine, homocysteinuria, butanesulfonyl, Penta-thinsulation, examinination, gettingresults-min) in very low compatible doses (e.g. pmol/kg to mmol/kg), (metal)chelating agents (for example, fatty α-hydroxy acid, palmitic acid, phytic acid, lacto-Ferrin), α-hydroxy acids (e.g. citric acid, lactic acid and malic acid), humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA acid, etilenditiodiuksusnoi acid and derivatives thereof, unsaturated fatty acids and their derivatives (e.g. γ-linolenic acid, linoleic acid and oleic acid), folic acid and its production is derivative, forwholesale and its derivatives, ubiquinone, original and their derivatives, vitamin C and its derivatives (for example, sodium ascorbate, ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbicacid), tocopherol and its derivatives (e.g. vitamin E acetate, tocotrienol), vitamin a and derivatives (vitamin-A-palmitate), as well as coniferales benzoin, retinabuy acid and its derivatives, α-glucosylrutin, Frolovo acid, formulaterules, carnosine, equivalent, butylhydroxyanisole, nordihydroguaiaretic resin acid, Nord-dihydroguaiaretic acid, trihydroxyacetophenone, uric acid and its derivatives, mannose and its derivatives, zinc and its derivatives (for example, ZnO, ZnSO4) selenium and its derivatives (for example, Selenomethionine), stilbene and its derivatives (for example, stilbenoid, TRANS-stilbene oxide).

According to the invention to the preferred vitamins include the vitamin or source of the product to obtain vitamins and their derivatives, and derivatives of 2-furanone.

Vitamin B1(trivial name thiamine, chemical name chloride 3-[(4'-amino-2'-methyl-5'-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-thiazole).

Vitamin b2(trivial name Riboflavin, chemical name 7,8-dimethyl-10-(1-D-ribitil)-benzo[g]pteridine-2,4(3H,10H)dione). Riboflavin in free form contains, for example, in the serum, whereas the derivatives of Riboflavin can be isolated from bacteria and yeast. According to the invention suitable stereoisomerism Riboflavin is excreted from fish meal or fish liver locksoflove that instead of the rest of D-ribityl contains the remainder of the D-arabitol.

Vitamin b3. This name is often used to refer to nicotinic acid and nicotinamide (Niacinamide). According to the invention, it is preferable amide of nicotinic acid.

Vitamin B5(Pantothenic acid and panthenol). According to the invention preferably uses panthenol. Used according to the invention derivatives of panthenol, first of all, are complex and ethers of panthenol, as well as cationic derivatives of panthenol. In another preferred embodiment of the invention in addition to Pantothenic acid or panthenol is also possible to use derivatives of 2-furanone. Especially preferred derivatives of 2-furanone are the following commercially available materials: dihydro-3 hydroxy-4,4-dimethyl-2(3H)-furanone with the trivial name pantolactone (Merck), 4-hydroxymethyl-γ-butyrolactone (Merck), 3,3-dimethyl-2-hydroxy-γ-butyrolactone (company Aldrich) and 2,5-dihydro-5-methoxy-2-furanone (Merck), including any CTE is SW-isomers.

These compounds preferably attached proposed in the invention dermocosmetics means the ability to return moisture and soothing the skin properties.

Vitamin B6under which in this case includes not only the substance, and various derivatives of 5-hydroxymethyl-2-methylpyridin-3-ol, known under the trivial names pyridoxine, pyridoxamine and pyridoxal.

Vitamin B7(Biotin), also known as vitamin H or "skin vitamin". Biotin is (3aS,4S,6aR)-2-oxohexanoate[3,4-d]-imidazole-4-Valerian acid.

According to the invention is even more preferred vitamins are panthenol, pantolactone, nicotinic acid amide and Biotin.

Dyes

According to the invention as dyes can be used is suitable and approved for cosmetic purposes the substance contained, for example, in the publication of the Commission on dyes of the German research society of Cosmetic dyes" (published Chemie, Weinheim, 1984). Such dyes are usually used in concentrations of from 0.001 to 0.1% of the mass. in terms of the total mixture.

Pigments

In a preferred embodiment of the invention proposed in the invention compositions contain at least one pigment. Pigments are a mixture of the composition in rastvorennoi condition, and that such content may be from 0.01 to 25 wt. -%, particularly preferably from 5 to 15% of the mass.. Preferred particle size of the pigments is from 1 to 200 μm, especially from 3 to 150 μm, particularly preferably from 10 to 100 μm. Pigments are coloring substances, which are practically insoluble in used for the application environment and can be both inorganic and organic substances. There are also mixed inorganic/organic pigments. According to the invention are preferred inorganic pigments. Advantages of inorganic pigments are their excellent light fastness, weather resistance and temperature resistance. Inorganic pigments can have a natural origin, for example, they can be made of chalk, ochre, umber, green clay, burnt Terra di Siena or graphite. Under the pigments mean white pigments such as titanium dioxide or zinc oxide, black pigments such as micaceous iron black, colored pigments, such as ultramarine or iron oxide red, glossy pigments, the pigments that mimic the color of the metal pigments with pearlescent and fluorescent or phosphorescent pigments, and at least one pigment is preferably colored (non-white pigment. Suitable pigments are oxides, hydroxides or exeggerated metals, heteroge-starecheski pigments, sulfur-containing silicates, sulfides of metals, complex metallocyanide, sulfates, chromates or molybdates of metals, as well as directly metals (such as bronze pigments). Suitable pigments are primarily titanium dioxide (Cl 77891), pigment black micaceous iron (Cl 77499), pigment yellow micaceous iron (Cl 77492), micaceous iron red and brown pigment (Cl 77491), pigment, manganese violet (Cl 77742), Ultramarines (sulfoxylate sodium-aluminum, Cl 77007, pigment blue 29), chromium hydroxide (S), iron blue (ferric ferrocyanide, Cl77510), Carmine (cochineal). According to the invention particularly preferred are pigments with mother-of-pearl luster and color pigments based on micanite, respectively mica particles are coated with oxide or oxychloride of the metal, such as titanium dioxide or bismuth oxychloride, and if necessary, other coloring agents such as iron oxides, iron blue, Ultramarines, Carmine, and so forth, and the color of which can be varied by changing the thickness of the coating. Sales of such pigments, for example, under the trade names Rona®, Colorona®, Dichrona®and Timiron®provides firm Merck. Organic pigments are the Xia, for example, natural pigments Sepia, gamboge, bone coal, Kassel yellow, Indigo, chlorophyll and other pigments of vegetable origin. Synthetic organic pigments are, for example, azo pigments, anthrachinone, indigene, dioxazine, chinaredorbit, phthalocyanine, IsoIn-dolinnoe, Pereladova, perinova, metal complex, alkali blue and diketopiperazine pigments.

In one variation of the proposed use in the invention, we accordingly proposed in the invention by the method of molecular imprinted active ingredient polymers that contain at least one substance in the form of particles in an amount of from 0.01 to 10 wt. -%, preferably from 0.05 to 5% by mass. in terms of composition. Suitable are, for example, having the form of particles of a substance that is solid at room temperature (25°C). Suitable substances of this type are, for example, silicon dioxide, silicates, aluminates, alumina, mica, salt, primarily inorganic metal salts, metal oxides, e.g. titanium dioxide, mineral and polymer particles. Particles remain undissolved in the environment, preferably stably dispersed in it and after application and evaporation of the solvent can be deposited on the surface of the application in solid form. Prepact the positive substances of this type are silicon dioxide (silica gel) and metal salts, first of all inorganic metal salts, and particularly preferred is silicon dioxide. Suitable metal salts are, for example, the halides of the alkali or alkaline earth metals, such as sodium chloride or potassium chloride, and sulfates of alkaline or alkaline earth metals such as sodium sulfate or magnesium sulfate.

Means to impart a pearlescent Shine

Suitable means to impart a pearlescent luster according to the invention are, for example, esters of alkalophile, in particular, ethylenglykolether, alkanolamide fatty acids, in particular, diethanolamide fatty acids of coconut oil, partial glycerides, in particular, monoglyceride of stearic acid, esters on the basis of polybasic, optionally substituted by hydroxyl carboxylic acids and aliphatic alcohols with 6 to 22 carbon atoms, in particular, long-chain esters of tartaric acid; fatty substances, such as aliphatic alcohols, aliphatic ketones, aliphatic aldehydes, aliphatic ethers, and aliphatic carbonates, total content of atoms carbon which is at least 24, in particular, Lauren and DISTEARYL ether; fatty acids such as stearic acid, hydroxystearate acid and Baganova acid is the same; the products resulting from interactions with the disclosure cycle epoxydecane olefins with 12-22 carbon atoms with aliphatic alcohols with 12-22 carbon atoms and/or polyhydric alcohols with 2 to 15 carbon atoms and 2 to 10 hydroxyl groups, and mixtures of the above compounds.

Thickening means commonly used in the compositions are crosslinked polyacrylic acids and derivatives thereof, polysaccharides and their derivatives such as xanthan gum, agar-agar, alginates or tyloz, cellulose derivatives, e.g. carboxymethylcellulose or hydroxycarbonylmethyl, aliphatic alcohols, monoglycerides, fatty acids, polyvinyl alcohol and polyvinylpyrrolidone. Preferably used nonionic thickeners.

Suitable cosmetically and/or dermocosmetics active active substances are, for example, coloring agents, agents pigmentation of skin and hair tone means, means for imitation tan, bleaches, keratin hardening substances, substances with antimicrobial action, filters, repellents, hyperemesis active substances, keratolytic and keratoplasticheskie active substances, antiseborrheic active substances, anti-inflammatory active substances, substances with keratinized is the missing action substances with antioxidant activity, respectively acceptors of free radicals, substances, moisturizing the skin and protects its natural moisture, nutrients, reducing fat, antiaritmicheskie or antiallergic active ingredients, branched fatty acids, such as 18-methylacetanilide acid, and also mixtures of these substances.

Substances used to simulate sunburn caused by exposure of the skin to natural or artificial ultraviolet light are, for example, dihydroxyacetone, alloxan and extract from the shell walnuts. Suitable curing keratin substances, as a rule, similar active substances used in antitranspirant, for example, such as aluminum sulfate, potassium hydroxychloride aluminum lactate, aluminum and so on.

Substances with antimicrobial action, is used to kill microorganisms or inhibiting their growth, and, therefore, they are deodorizing substances that inhibit the appearance of coming from body odor or reduce its intensity. Such substances include, for example, a conventional well-known specialists preservatives such as esters of p-hydroxybenzoic acid, imidazolidinecarboxamide, formaldehyde, sorbic acid, benzoic acid, Salic the gross acid and so on.

According to the invention preferably use preservatives listed in table 4 (the numbering corresponds to the Directive of the European economic community 95/2/EEC).

Table 4
Suitable preservatives
E200Sarbianova acidEHydrosulfite calcium
E201Sodium sorbateEHydrosulfite potassium
E202Potassium sorbateE230Biphenyl (diphenyl)
ECalcium sorbateEOrthophenylphenol
EBenzoic acidEOrthophenylphenol sodium
E211Sodium benzoateEThiabendazol
E Potassium benzoateENatamycin
EBenzoate calciumEFormic acid
EComplex ethyl ester of p-hydroxy-benzoic acidEFormate sodium
ESodium salt of ethyl ester of p-hydroxybenzoic acidEformate calcium
EComplex n-propyl ester of p-hydro-ximenting acidE239Hexamethylenetetramine
ESodium salt of n-propyl ester of p-hydroxybenzoic acidENitrite potassium
EMethyl ester of p-hydroxybenzoic acidE250Sodium nitrite
ESodium salt of methyl ester of p-hydroxybenzoic acid E251Sodium nitrate
E220Sulfur dioxideEPotassium nitrate
ESodium sulfiteThe E280Propionic acid
E222Hydrosulfite sodiumEThe sodium propionate
E223Disulfit sodiumECalcium propionate
EDisulfit potassiumEPotassium propionate
EThe calcium sulfiteECarbon dioxide

In addition, according to the invention is suitable preservatives are commonly used in cosmetics preservatives or auxiliary means of preservation, such as dibromodicyanobutane (2-bromo-2-bromodichlorometan), 3-iodine-2-propynylbutylcarbamate, 2-bromo-2-nitropropane-1,3-diol, imidazolidinecarboxamide, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-aracetamol, chloride benzalconia and benzyl alcohol. Suitable preservatives are also simple phenyl-hydroxyalkyl esters, above all, a compound known under the name Phenoxyethanol, which provides effective bactericidal and fungicidal effect on lots of different microorganisms.

In the structure proposed in the invention of the drugs can be administered as others inhibit the growth of microorganisms funds. Preferred agents of this type are, for example, a simple 2,4,4'-tri-chloro-2'-hydroxydiphenyl ether (irgasan), 1,6-di(4-chlorophenylurea-Nido)hexane (chlorhexidine), 3,4,4'-trichlorocarbanilide, Quaternary ammonium compounds, clove oil, menthol oil, thyme oil, triethylcitrate, farnesol (3,7,11-trimethyl-2,6,10-dodecatrien-1-ol), as well as active substances, respectively, the combination of active substances that are listed in the descriptions of the German patents DE-3740186, DE-3938140, DE-4204321, DE-4229707, DE-4309372, DE-4411664, DE-19541967, DE-19543695, DE-19543696, DE-19547160, DE-19602108, DE-19602110, DE-19602111, DE-19631003, DE-19631004 and DE-19634019, DE-4229737, DE-4237081, DE-4324219, DE-4429467, DE-4423410 and DE-19516705. Preferred is also the use of sodium bicarbonate. In addition, as preservatives can be used microbial polypeptides.

Perfume oils

Cosmetic compositions, if necessary, may contain perfume oil is. Suitable perfume oils are, for example, mixtures of natural and synthetic aromatic substances. Natural fragrances are extracts from flowers (Lily, lavender, rose, Jasmine, neroli, Cananga fragrant), stems and leaves (geranium, patchouli, Petit grain), fruits (anise, coriander, caraway, juniper), fruit peel (bergamot, lemon, orange), roots (Makis, Angelica, celery, cardamom, Costus, iris, calamus), wood (pine, sandalwood, guaiac wood, cedarwood, rosewood), herbaceous plants and grasses (tarragon, lemongrass, sage, thyme), needles and branches (spruce, fir, pine, mountain pine), resins and resin (galbanum, elemi, Rosen frankincense, myrrh, olibanum, opoponax). In addition, use of raw materials of animal origin, for example, civet and castoreum. Typical synthetic fragrances are products of the type of esters, ethers, aldehydes, ketones, alcohols and hydrocarbons. To a fragrant substances such esters include, for example, benzoylacetate, phenoxyethyl-isobutyrate, 4-tert-butylcyclohexylamine, minalrestat, dimetilan-sicarbonate, fenilatilamin, lisalivingood, benzoylformate, ethylmethylketone, arylcyclohexylamines, styrallyl-piont and benzalkonium. Simple esters include, for example, Ben-Piletilevi ether, aldehydes, n is the sample, unbranched saturated aldehydes with 8-18 carbon atoms, citral, citronellal, citronellaldehyde, collateralized, hydroxy, citronellal, lilial and bourgeonal, ketones, for example, ionone, SS-isomethyl-ionone and methylsilicon, alcohols, for example, anethole, limonene alcohol, eugenol, isoeugenol, geraniol, linalool, phenethyl alcohol and terinea, the hydrocarbons include primarily the terpenes and balsams. However, it is preferable to use a mixture of different aromatic substances, together ensure a pleasant note of the smell. Suitable perfume oils are also low-volatile essential oils, in most cases, used as a flavouring components, e.g. sage oil, camomile oil, clove oil, balm oil, mint oil, cinnamon oil, lime blossom oil, juniper oil, vetiverol, oil olibanum, the essence of galbanum, oil labelenumi and of Lavandin oil. Preferably use bergamot oil, dihydromyrcenol, lilial, lyral, lemon alcohol, phenethyl alcohol, α-exilarchy aldehyde, geraniol, benzylacetone, collateralized, linalool, product Boisambrene®Forte, ambroxan, indole, methyldihydromorphine, Candelo, lemon oil, tangerine oil, orange oil, allylamines, cyclopentyl, lavande the TV oil, Clary sage oil, β-Damasco, geranium oil Bourbon, cyclohexylglycine, Vertofix®Coeur, Iso-E-Super®, Fixolide®NP, averil, Iraldein gamma, phenylacetic acid, n-uranylacetate, benzoylacetate, Roztocze, roumillat, erotic and format (individually or as mixtures).

Oils, fats and waxes

Proposed in the invention compositions contain at least one fatty phase. Under the fat phase mean oil, fat and/or wax. The components of oil and/or fat phase proposed in the invention compositions are preferably chosen from the group comprising lecithin and triglyceride fatty acids, in particular, complex truefire on the basis of glycerol and saturated and/or unsaturated, branched and/or unbranched alkenylboronic acids with 8 to 24, especially 12 to 18 carbon atoms in the alkyl residue. Triglycerides of fatty acids, for example, may be compounds, preferably selected from the group comprising synthetic, semisynthetic and natural oils, such as olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, castor oil, oil of wheat germ, winiarnia oil, chertopolohom oil, evening primrose oil, macedonianboy oil and similar oils. Other polar oil comp the components can be selected from the group including esters on the basis of saturated and/or unsaturated, branched and/or unbranched alkenylboronic acids from 3-30 carbon atoms in the alkyl residue and saturated and/or unsaturated, branched and/or unbranched alcohols with 3 to 30 carbon atoms in the alkyl residue, as well as from the group comprising esters on the basis of aromatic carboxylic acids and saturated and/or unsaturated, branched and/or unbranched alcohols with 3 to 30 carbon atoms in the alkyl residue. Such esters are preferably can be selected from the group including isopropylmyristate, isopropyl, isopropylthio, isopropylacetate, n-butylester, n-exellent, n-decillia, isoeccentric, sonnystitt, isononylphenol, 2-ethylhexylamine, 2-ethylhexylamine, 2-hexyldecanol, 2-octyldodecanol, aerolef, realroot, erozilla, arazilerinin dicaprylyl carbonate (Cetiol CC), cocoglycerides (Myritol 331), butyleneglycol/dicaprate and debutylation, and synthetic, semisynthetic and natural mixtures of such esters, such as jojoba oil.

In addition, one or more oil component preferably can be selected from the group comprising branched and unbranched hydrocarbons and hydrocarbon waxes, silicon is s oil simple dialkyl ethers, saturated or unsaturated, branched or unbranched alcohols. In accordance with the present invention preferably use any mixtures of such oil and wax components. In some cases, it may be preferred also use waxes, for example, cetylpalmitate, as the sole lipid component of the oil phase. According to the invention the oil component is preferably chosen from the group comprising 2-ethylhexylphthalate, octyldodecanol, isotridecyl-Nanuet, isoeicosane, 2-ethylhexylamine, alkylbenzoates with 12-15 carbon atoms in the alkyl, triglyceride Caprylic/capric acid and dick-pillowy esters. According to the invention the preferred oil components are a mixture of alkylbenzoates with 12-15 carbon atoms in the alkyl 2-ethylhexylphthalate, a mixture of alkylbenzoates with 12-15 carbon atoms in the alkyl with isotretinoin.com, as well as mixtures of alkylbenzoates with 12-15 carbon atoms in the alkyl 2-ethylhexyl-isostearate and isotretinoin.com. According to the invention as oils with a polarity from 5 to 50 mn/m, particularly preferably using a triglyceride of fatty acids, primarily soybean oil and/or almond oil. In accordance with the present invention, the preferred hydrocarbon is aslami are paraffin oil, squalane and squalene.

Along with this, the oil phase preferably may be selected from the group comprising alcohols Arms. The synthesis of these alcohols was first described by Marcel Arms. They are formed by the reaction proceeding in accordance with the equation:

Δ

as a result of oxidation of alcohol to aldehyde, aldol condensation of the aldehyde, the removal of water from aldos and hydrogenation of arilaldegidov. Alcohols Emblem at low temperatures are liquids that are unlikely to cause skin irritation. In cosmetic preparations preferably can be used as giving oiliness, and perezharivaya or reducing the fat content of the components.

About the use of alcohols Emblem in cosmetic preparations, in principle, known. The corresponding alcohols have the formula:

,

in which R1and R2usually means an unbranched alkyl residue.

According to the invention are preferred alcohols Emblem of the above formula in which the substituents R1and R2mean:

R1means propyl, butyl, pentyl, hexyl, heptyl or octyl and

R2means hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl or tetradecyl.

According to the invention FAV is titlename alcohols Arms are 2-butyloctyl (for example, in the form of a commercially available product Isofol®12 firm Condea) and 2-hexyldecanol (for example, in the form of a commercially available product lsofol®16 firm Condea). According to the invention, it is preferable to use mixtures proposed in the invention of alcohols Emblem, such as a mixture of 2-butyloctyl with 2 hexyldecanol, for example, a commercially available product Isofol®14 firm Condea.

In accordance with the present invention, it is preferable to use any mixtures of these oil and wax components. However, preferred polyolefins include polydecene.

In addition, the oil component preferably may contain cyclic or unbranched silicone oil or may be entirely of such oils, in addition to the silicone oil or silicone oils oil component preferably should contain other components in the oil phase. Low molecular weight silicones or silicone oils generally have the General formula:

.

High molecular weight silicones or silicone oils generally have the following General formula:

,

in which the silicon atoms in the General case can be substituted by the same or different alkyl and/or aryl mod is AMI R 1-R4. The number differs from each other residues are not necessarily limited to four. The index m can mean a number from 2 to 200,000.

According to the invention to be preferred to the use of cyclic silicones generally have the General formula:

,

in which the silicon atoms in the General case can be substituted by the same or different alkyl and/or aryl residues R1-R4. The number differs from each other residues are not necessarily limited to four. The index n may indicate a number from 3/2 to 20. Fractional values code n mean that in a loop can be an odd number siloxanic groups.

Preferred silicone oil is phenyl-trimeton. In accordance with the present invention preferably can be used other silicone oils such as Dimethicone, hexamethylcyclotrisiloxane, vinyldimethyl, cyclomethicone (for example, octamethylcyclotetrasiloxane), hexamethylcyclotrisiloxane, polydimethylsiloxane, poly(methylphenylsiloxane), acidisation or beginanimation. In addition, it is preferable to use mixtures of cyclomethicone with isotretinoin.com and cyclomethicone 2-ethylhexylphthalate. In addition, suppose that the equipment is the use of silicone oils of the above patterns, organic side chains which, for example, subjected to polyethoxysiloxane and/or polipropilenovuyu. Such compounds include, for example, copolymers with the structure of polyelectrolites - simple polyester, such as copolyol acidisation. According to the invention is preferably used silicone oil is cyclomethicone (octamethylcyclotetrasiloxane). According to the invention to be preferred to the use of fatty and/or wax components can be selected from the group comprising vegetable, animal, mineral and petrochemical waxes. The preferred waxes are, for example, kandellilsky wax, Carnauba wax, Japan wax, Esparto wax, cork wax, wax, guaruma, wax from rice embryos, the wax of sugar cane, berry wax, wax ouricuri, Montan-wax, wax str, Shea butter, beeswax, shellac wax, spermaceti, lanolin (wool wax), fat bird Asses, ceresin, ozocerite (earth wax), paraffin wax and microvasc.

Other preferred fatty and/or wax components are chemically modified and synthetic waxes, such as Syncrowax®HRC (glyceryltrinitrate) and Syncrowax®AW 1C (fatty acid with 18-36 carbon atoms), montanarini wax, wax company Sasol, hydrogenated wax Jo is both synthetic or modified bee waxes (e.g. beeswax Dimethicone copolyol and/or beeswax with alkilani with 30-50 carbon atoms), cetirizine, such as Tegosoft®CR, polyalkylene wax, polietilenglikolya wax, chemically modified fats, such as hydrogenated vegetable oils (for example, gidrirovannoe castor oil and/or hydrogenated glycerides of coconut oil), triglyceride, such as hydrogenated soy glycerides, trihydroxystearin, fatty acids, esters of fatty acids and esters of glycols, such as alkylesters with 20-40 carbon atoms in the alkyl, alkylhydroxylamines with 20-40 carbon atoms in the alkyl and/or glycomimetic. Other preferred components are also certain organosilicon compounds with physical properties similar to the above fat and/or waxy substances, such as laroxetine-silane.

According to the invention, the fatty and/or wax components can be used in the drugs separately and as mixtures. According to the invention, it is preferable to use mixtures of the above fatty and waxy components of any composition. The oil phase is preferably chosen from the group comprising 2-the Teal-hexylester, octyldodecanol, isotretinoina, butyleneglycol/dicaprate, 2-ethylhexylamine, alkylbenzoic with 12-15 carbon atoms in the alkyl, triglyceride Caprylic/capric acid and dicaprylyl ether. Especially preferred is the use of mixtures of octyldodecanol, triglyceride Caprylic/capric acid, dicaprylyl ether, disabilitant and cocoglycerides, mixtures of alkylbenzoates with 12-15 carbon atoms in the alkyl and 2-ethylhexyl-isostearate, mixtures of alkylbenzoates with 12-15 carbon atoms in the alkyl and butyleneglycol/dicaprate, as well as mixtures of alkylbenzoates with 12-15 carbon atoms in the alkyl, 2-ethylhexylacrylate and attributemetadata. Preferably used are hydrocarbons in accordance with the invention are paraffin oil, cycloparaffin, squalane, squalene, and hydrogenated polyisobutene, respectively polydecene.

In addition, the oil component is preferably chosen from the group comprising phospholipids. Phospholipids are esters of phosphoric acid and acylated glycerine. Among phosphatidylcholines of the greatest importance, for example, lecithins, which have the General formula:

,

in which R' and R" in typical cases mean non-branched aliphatic residue with 15 or 17 carbon atoms, with the holding up to four CIS-double bonds.

As the preferred paraffin oil according to the invention can be used Merkur vaseline oil Weissol Pharma 40 company Merkur Vaseline, Shell Ondina®917, Shell Ondina®927, Shell Oil 4222 and Shell Ondina®933 firm Shell &DEA Oil and Pionier®6301 S and Pionier®2071 company Hansen &Rosenthal. Suitable cosmetically compatible oil and fat components are described in the Handbook Karl-Heinz Schrader, Grundlagen und Rezepturen der Kosmetika, 2nd edition, publisher Huthig, Heidelberg, s-355, which should be considered by an appropriate reference.

Solvents

In the case of use of the present in invention, we accordingly proposed in the invention by the method of molecular imprinted active ingredient polymers in cosmetic or dermatological preparations, representing a solution, emulsion or dispersion, the composition can be included the following solvents.

Water or aqueous solutions; oils, such as triglyceride capric or Caprylic acid, preferably castor oil; fats, waxes and other natural and synthetic aliphatic compounds, preferably esters based on fatty acids and short-chain alcohols, such as isopropanol, propylene glycol or glycerol, or on the basis of aliphatic alcohols and short-chain or long-chain fatty acids; briefly ipotechnye alcohols, diols or polyols and their ethers, preferably ethanol, isopropanol, propylene glycol, glycerin, ethylene glycol, monotropy ether of ethylene glycol, monobutyl ether of ethylene glycol, onomatology ether of propylene glycol mono-ethyl ether of propylene glycol, monobutyl ether of propylene glycol, onomatology ether of diethylene glycol, monotropy ether of diethylene glycol and similar substances. First of all, use a mixture of these solvents. Alcohol solvents as an additional component may contain water.

Surfactants

According to the invention the composition in addition to the proposed invention, we accordingly proposed in the invention by the method of molecular imprinted active ingredient polymers may also contain surfactants. Suitable surfactants are, for example:

the esters and salts of phosphoric acid, such as DEA-IG-10 phosphate and delaure-4 phosphate,

the alkyl sulphonates, for example, nutricionortomolecular, sodium C12-14reincorporate, nutritionrelated and magnesium peg-3 karamitsuita,

- carboxylic acids and their derivatives, such as lauric acid, aluminum stearate, Alkonost magnesium and undecylenate zinc, esters of carboxylic acids, for example, is antisterility, Laureth-6 citrate and sodium polyethylene-glycol-4 lauramidopropyl,

- esters, the products of esterification of carboxylic acids with ethylene oxide, glycerol, sorbitane or other alcohols,

- ethers, for example ethoxylated alcohols, ethoxylated lanolin, ethoxylated polysiloxane, propoxycarbonyl ethers and alkylpolyglycoside such as laurelhouse, decollimated and cocoglucoside.

Polysorbate

According to the invention in addition to the proposed invention, we accordingly proposed in the invention by the method of molecular imprinted the active ingredient of the polymer composition can also contain Polysorbate.

However, in accordance with the invention the preferred Polysorbate are (CAS-Nr. means the identification number in Chemical Abstracts):

- polyoxyethylene(20)sorbitanoleat (Tween 20, 9005-64-5),

- polyoxyethylene(4)sorbitanoleat (Tween 21, CAS-Nr. 9005-64-5),

- polyoxyethylene(4)servicemonitor (Tween 61, CAS-Nr. 9005-67-8), polyoxyethylene(20)corbettreport (Tween 65, CAS-Nr. 9005-71-4),

- polyoxyethylene(20)servicemanual (Tween 80, CAS-Nr. 9005-65-6),

- polyoxyethylene(5)servicemanual (Tween 81, CAS-Nr. 9005-65-5) and

- polyoxyethylene(20)sarbatorile (Tween 85, CAS-Nr. 9005-70-3).

Especially preferred Polysorbate, first of all, are:

- polyoxyethylene(20)SOR is itemenabled (Tween 40, CAS-Nr. 9005-66-7) and

- polyoxyethylene(20)servicemonitor (Tween 60, CAS-Nr. 9005-67-8).

According to the invention the preferred content of these used individually or in a mixture of Polysorbate is from 0.1 to 5 wt. -%, first of all, from 1.5 to 2.5% of the mass. in terms of the total weight of the composition.

Means of air conditioning

In a preferred variant of the invention, the compositions also contain a means of conditioning (air conditioning). According to the invention preferred are air-conditioned, for example, compounds that are described in section 4 of volume 4 of the International nomenclature of cosmetic ingredients (International Cosmetic Ingredient Dictionary and Handbook - INCI, publisher R.C. Pepe, J.A. Wenninger, G.N. McEwen, The Cosmetic, Toiletry, and Fragrance Association, 9th edition, 2002) under the names of Hair Conditioning Agents, Humectants, Skin-Conditioning Agents, Skin-Conditioning Agents-Emollient, Skin-Conditioning Agents-Humectant, Skin-Conditioning Agents-Miscellaneous, Skin-Conditioning Agents-Occlusive and Skin Protectans and in accordance with European patent application EP-A 934956 (C.11-13 description) is water-soluble or oil soluble conditioning agents. Other preferred conditioners are, for example, compounds in accordance with the INCI nomenclature called Polyquaternium (especially products from Polyquaternium-1 to Polyquaternium-56).

Suitable conditioners include, for example, also polymeric Quaternary ammonium soy is inane, cationic cellulose derivatives and polysaccharides.

In this preferred according to the invention, the conditioning can be selected from the table 1 compounds.

Table 5
Be preferred to use the air conditioning
Name according to INCIThe number in Chemical AbstractsThe type of polymerExample (trade name)
Polyquaternium-2CAS 63451-27-4Urea, N,N", polymer bis[3-(dimethylamino)propyl] with 1,1'-oxybis-(2-chlorethane)Merquat®A-15
Polyquatermum-5CAS 26006-22-4Acrylamide, β-methacryloxyethyl-triethylammonium methosulfate
Polyquatemium-6CAS 26062-79-3N,N-dimethyl-N-2-propenyl-2-propanamine chlorideMerquat®100
Polyquatemium-7CAS 26590-05-6N,N-dimethyl-N-2-propenyl-2-propanamine chlorite is, 2-propenamideMerquat®S
Polyquaternium-10CAS 53568-4, 55353-19-10, 54351-50-7, 68610-92-4, 81859-24-7Quaternary ammonium salt of hydroxyethyl celluloseCelquat®SC-230M, Polymer JR400
Polyquaternium-11CAS 53633-54-8The product of the interaction of the copolymer of vinyl pyrrolidone/dimethylaminoethylmethacrylate with diethylsulfateCelquat®755N
Polyquatemium-16CAS 29297-55-0Copolymer of vinyl pyrrolidone/vinylimidazole methochlorideLuviquat®HM552
Polyquatemium-17CAS 90624-75-2Mirapol®AD-1
Polyquaternium-19CAS 110736-85-1Quaternionic water-soluble polyvinyl alcohol
Polyquaternium-20CAS 110736-86-2Water-dispersible quaternionic polivinilbutilovy ether
Polyquaternium-21 The copolymer of polysiloxane/polidi-methyldiethylamine acetateAbil®B 99905
Polyquaternium-
22
CAS 53694-17-0The copolymer of dimethyldiallylammonium chloride/acrylic acidMerquat®280
Polyquaternium-
24
CAS 107987-23-5Polymer kvaternikova ammonium salt of hydroxyethyl celluloseQuartisoft®LM-200
Polyquaternium-
28
CAS 131954-48-8Copolymer of vinyl pyrrolidone/methacrylamidoethylene chlorideGafquat®HS-100
Polyquatermum-29CAS 92091-36-6,148880-30-2Chitosan is subjected to interaction with propylene oxide and quaternionic the epichlorohydrinLexquat®CH
Polyquatemium-31CAS 136505-02-7,139767-67-7Polymer kvaternikova ammonium salt, obtained by the interaction of the copolymer DMAPA-acrylate/acrylic acid/Acrylonitrile with diethylsulfateHypan®QT100
Polyquatermum-32CAS 35429-19-7Copolymer of N,N,N-trimethyl-2-{[82-methyl-1-oxo-2-propenyl)oxy)}-ethanamine chloride/2-propenamide
Polyquatemium-37CAS 26161-33-1
Polyquatemium-44Quaternary ammonium salt with a polymer of vinylpyrrolidone with quaternions imidazoline

Other preferred according to the invention are air-conditioned derivatives of cellulose and quaternion the guar derivative resin, especially a chloride of qualitatsprodukten (for example, Jaguar Excel®and With Jaguar 162®the company Rhodia, CAS 65497-29-2, CAS 39421-75-5).

As air conditioners according to the invention can preferably also be used non-ionic copolymers of poly-N-vinylpyrrolidone with polyvinyl acetate (for example, Luviskol®VA 64 BASF), anionic acrylic copolymers (for example, Luviflex®Soft BASF) and/or amphoteric copolymers based amide, acrylate and methacrylate (for example, Amphomer®company National Starch).

Materials powder

In the General case according to the invention, it may be preferable added on the materials in the form of powder. As such materials are particularly preferably used talc.

Ethoxylated esters on the basis of glycerol and fatty acids

According to the invention, in addition to molecular imprinted polymers, the composition can also contain ethoxylated oils selected from the group comprising ethoxylated esters on the basis of glycerol and fatty acids, primarily glycerides preferably the peg-10 olive oil glycerides of the peg-11 avocado oil, glycerides of the peg-11 cocoa butter, the glycerides peg-13 sunflower oil, polyethylene glycol-15 glycerylmonostearate, glycerides of polyethylene glycol-9 fatty acids of coconut oil, peg-54 gidrirovannoe castor oil, peg-7 gidrirovannoe castor oil, peg-60 gidrirovannoe castor oil ethoxylate oil str (the glycol-26 jojoba-fatty acids, polyethylene glycol-26 jojoba-alcohol), glycereth-5 Cocoate, glycerides of polyethylene glycol-9 fatty acids of coconut oil, peg-7 literallayout, the glycerides peg-45 palm kernel oil, peg-35 castor oil, esters olive oil peg-7, the glycerides peg-6 Caprylic/capric acid glycerides of polyethylene glycol-Alibekova oil, the glycerides of the peg-13 sunflower oil, peg-7 gidrirovannoe castor oil, hydrogenated palm kernel glycerides oil-ether polyethylene glycol-6, the glycerides peg-20 corn oil, polyethylene glycol-18 glyceraldehyd, polyethylene glycol-40 gidrirovannoe castor oil, peg-40 castor oil, peg-60 gidrirovannoe castor oil, glycerides of polyethylene glycol-60 corn oil, peg-54 gidrirovannoe castor oil, glycerides of the peg-45 palm kernel oil, peg-80 literallayout, the glycerides peg-60 almond oil, glycerides of polyethylene glycol-60 evening primrose oil, peg-200 hydrogenated literalmath and polyethylene glycol-90 glits-resizestart.

Preferred ethoxylated oils are polyethylene glycol-7 literallayout, peg-9 cocoglycerides, polyethylene glycol-40 gidrirovannoe castor oil, and peg-200 hydrogenated glycerylphosphorylcholine esters on the basis of glycerol and fatty acids used in the formulation of cleaning agents with different goals. Nizkokaloriynye esters (from 3 to 12 ethylene oxide units) are usually used as tools for recovery of oily skin with a the Yu improve its organoleptic properties after drying, while the esters with a degree of amoxilonline located in the approximate range of 30 to 50 are solubilisation used to dissolve non-polar substances, such as perfume oils. Esters with a high degree of amoxilonline used as thickeners. The peculiarity of all these substances is the ability after dilution with water to give the skin an optimal organoleptic properties (pleasant feeling to the touch).

Sunscreen

According to the invention proposed in the invention, we accordingly proposed in the invention by the method of molecular imprinted active ingredient polymers used in dermocosmetics drugs in combination with sunscreen. Such cosmetic and/or dermatological sunscreen compositions are intended for cosmetic and/or dermatological protection from the action of light, for the treatment and care of the skin and/or hair, as well as gamerules component in decorative cosmetics. These include, for example, sunscreens, lotions, lotions, oils, balms, gels and lipsticks, moisturizers, lotions and emulsions, creams for face, body and hands, leczenie means for washing and rinsing hair, clips hair, styling gels, sprays for the hair ball is passed deodorants, creams against wrinkles around the eyes, cream for local application, shading pencils and preparations for use after sunbathing. All these preparations contain at least one of the molecular imprinted active ingredient polymers and one of the above-mentioned UV filters.

Sunscreen oils are usually mixtures of different oils with one or more light filters and perfume oils. The oil components are characterized by different cosmetic properties. Oil that gives the skin optimum fat and pleasant organoleptic properties, such as mineral oils (e.g. paraffin oil) and triglyceride fatty acids (for example, peanut oil, sesame oil, avocado oil, a triglyceride with an average length of the chains), mixed with oils improves the distribution and absorption of the sunscreen oils in the skin, and also reduces the stickiness and ensuring the permeability of the oil film to air and moisture vapor (sweat). The latter include esters of branched fatty acids (e.g., isopropyl) and silicone oil (for example, dimethylsilicone). When using oils on the basis of unsaturated fatty acids to prevent rancidity to tracks add antioxidants, such as tocopherol. Sun oil are what I anhydrous compositions, usually do not contain preservatives. Sunscreen lotion and creams are made in the form of emulsions of the type oil-in-water" and "water in oil". Properties of drugs vary greatly depending on the type of emulsion. The emulsion of the type oil-in-water" easily distributed on the surface of the skin, in most cases, rapidly absorbed and almost always washed with water. Emulsion type water in oil rubbed harder into the skin, giving it a higher fat content and therefore stickiness, however, better protect the skin from drying out. Emulsion type water in oil" in most cases are waterproof. A crucial role for water emulsions of the type oil-in-water" is the choice of an appropriate basis, suitable light protection substances and optionally used auxiliary substances (e.g., polymers). Composition of liquid and creamy emulsions of the type oil-in-water" similar to other commonly used for skin care emulsions. Sun milk should provide the oiliness of the skin, sufficient for the absence of its drying under the sun, water and wind. It should not make the skin sticky, because in the conditions of heat and contact with sand it can be particularly unpleasant sensations. The basis of the light protection agents, as a rule contains at least one oil phase, However, it is also possible the manufacture of compositions on the basis of one water. Thus, we are talking about oils, emulsions of the type oil-in-water and water in oil, creams, pastes, mixtures for the manufacture of protective lipstick or not containing fat gels. In addition, in particular, it is possible to make macroamylase and microemulsions of the type oil-in-water or emulsions of the type oil/water/oil supplied with coating dispergirovannykh particles of titanium dioxide, which may be made in accordance with the technology of the treatment phase (see German patent application DE-A-19726121).

Conventional cosmetic excipients that can be used as additives are, for example, (co), emulsifiers, fats and waxes, stabilizers, thickeners, biogenic active substances, film formers, fragrances, dyes, means to impart a pearlescent luster, preservatives, pigments, electrolytes (e.g. magnesium sulfate), and regulators of pH. As stabilizers it is possible to use metal salts and fatty acids, such as magnesium stearate, aluminum stearate and/or zinc stearate. Suitable biogenic active substances are, for example, plant extracts, protein hydrolysates and vitamin complexes. Suitable binders are, for example, hydrocolloids, such as chitosan, microcrystalline chitosan is whether Quaternary chitosan, polyvinylpyrrolidone, copolymers of vinylpyrrolidone with vinyl acetate, polymers of a number of acrylic acid, Quaternary cellulose derivatives and similar compounds.

Suitable Sitophilus agents are substances that absorb UV rays in the UV-b and/or UV-a region of the spectrum. These organic substances are able to absorb ultraviolet rays and return the absorbed energy in the form of lenovolenovo radiation, for example, in the form of heat. Organic matter can be oil soluble or water soluble. Suitable UV filters are, for example, 2,4,6-Triaryl-1,3,5-triazine corresponding aryl group which may contain at least one Deputy, preferably selected from the group comprising hydroxy, alkoxy, in particular methoxy, and alkoxycarbonyl, in particular, methoxycarbonyl or etoxycarbonyl. Suitable UV filters are also esters of p-aminobenzoic acid, esters of cinnamic acid, benzophenone, camphor derivatives, as well as inhibiting UV rays pigments, such as titanium dioxide, talc and zinc oxide. Especially preferred are pigments based on titanium dioxide.

As oil-soluble UV-b filters can be used, for example, the following substances:

3-benzylideneamino and its derivatives, is for example, 3-(4-methylbenzyl-den)camphor,

derivatives of 4-aminobenzoic acid, preferably 2-ethylhexyloxy ester of 4-(dimethylamino)benzoic acid, 2-oktilovom ester of 4-(dimethylamino)benzoic acid amyl ester of 4-(dimethylamino)-benzoic acid,

esters of cinnamic acid, preferably 2-ethylhexyloxy ether 4-methoxycatechol acid, propyl ester 4-methoxycatechol acid, isoamyl ester 4-methoxycatechol acid, isopentylamine ether 4-methoxycatechol acid and 2-ethylhexyloxy ester 2-cyano-3-phenylcarbinol acid (octocrylene),

esters of salicylic acid, preferably 2-ethylhexyloxy, 4-isopropylbenzylamine or momenteraly ester of salicylic acid,

derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzo-none, 2-hydroxy-4-methoxy-4'-methylbenzophenone and 2,2'-dihydroxy-4-methoxybenzophenone,

esters of benzylmalonate acid, preferably di-2-ethylhexylamine ether 4-methoxybenzylamine acid,

derivatives of triazine, such as 2,4,6-trainline-(p-Carbo-2'-ethyl-1'-hexyloxy)-1,3,5-triazine (ochiltree), dioctyl butamide treason (Uvasorb®HEB)

propane-1,3-diones, such as 1-(4-tert-butylphenyl)-3-(4'-methoxyphenyl)propane-1,3-dione.

As water-soluble substances you can use the following connections:

2-FeNi is a benzimidazole-5-acid and its salts with alkali or alkaline earth metals, and ammonium salts of alkylamine, alkanolamine and glucamine,

sulfoxylate derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone-5-acid and its salt,

sulfonylurea derivatives of 3-benzylideneacetone, such CAC-(2-oxo-3-barelydigital)benzosulfimide, 2-methyl-5-(2-oxo-3-borrelidin)acid and the corresponding salt.

Especially preferred is the use of esters of cinnamic acid, preferably 2-ethylhexanol ether 4-methoxycatechol acid, isopentanol ether 4-methoxycatechol acid and 2-ethylhexanol ester 2-cyano-3-phenylcarbinol acid (octocrylene).

In addition, it is preferable to use benzophenone derivatives, especially 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone or 2,2'-dihydroxy-4-methoxy-benzophenone, and propane-1,3-diones, such as 1-(4-tert-butylphenyl)-3-(4'methoxyphenyl)propane-1,3-dione.

Typical suitable UV-a filters are:

derivatives benzoylamino, such as 1-(4'-tert-butyl-phenyl)-3-(4'-methoxyphenyl)propane-1,3-dione, 4-tert-butyl-4'-methoxy-dibenzoylmethane or 1-phenyl-3-(4'-isopropylphenyl)propane-1,3-dione,

aminohydroxylation derivatives of benzophenone, such as N,N-Diethylaminoethanol-n-exile seat.

Obviously, you can also use a mixture of UV-a and UV-b filters.

Other suitable UV filter substances are shown in table 6.

Table 6
Suitable light protection substances
RoomSubstanceRegistration number in Chemical Abstracts (acid)
14-Aminobenzoic acid150-130
23-(4'-Ammonium)benzylideneamino-2-he-methyl sulfate52793-97-2
33,3,5-Trimethylcyclohexylamine(homosalate)118-56-9
42-Hydroxy-4-methoxybenzophenone(oxybenzone)131-57-7
52-Phenylbenzimidazol-5-acid and salts of potassium, sodium and triethanolamine27503-81-7
63,3'-(1,4-Phenylendiamine)bis(7,7-dimethyl-2-oxo-bicyclo[2.2.1]heptane-1-methanesulfonate) and its salts 90457-82-2
7Complex polyethoxyethanol ether 4-bis(polyatomic)aminobenzoic acid113010-52-9
8Complex 2-ethylhexyloxy ether 4-dimethylamino-benzoic acid21245-02-3
9Complex 2-ethylhexyloxy ester of salicylic acid118-60-5

RoomSubstanceRegistration number in Chemical Abstracts (acid)
10Complex 2-isoamyl ether 4-methoxycatechol acid71617-10-2
11Complex 2-ethylhexyloxy ether 4-methoxycatechol acid5466-77-3
122-Hydroxy-4-methoxybenzophenone-5-acid (sulisobenzone) and its sodium salt4065-45-6
133-(4'-Sulfonanilide)Bornand-2-he and its salts58030-58-6
14 3-Benzylideneamino-2-he16087-24-8
151-(4'-Isopropylphenyl)-3-phenylpropane-1,3-dione63260-25-9
164 Isopropylbenzylamine94134-93-7
173-Imidazol-4-Lacrimosa acid and its complex ethyl ester104-98-3
18Complex ethyl ester of 2-cyano-3,3-diphenylene-ash acid5232-99-5
19Complex 2'-ethylhexyloxy ester 2-cyano-3,3-diphenylacetone acid6197-30-4
20Menthyl-o-aminobenzoate or 5-methyl-2-(1-methyl-ethyl)-2-aminobenzoate134-09-8
21Glyceryl-p-aminobenzoate or complex 1-glyceri-levy ester of 4-aminobenzoic acid136-44-7
222,2'-Dihydroxy-4-methoxybenzophenone(dioxybenzone)131-53-3
232-Hydroxy-4-methoxy-4-methylbenzo the non (Maxton) 1641-17-4
24Triethanolaminato2174-16-5
25Dimethoxyphenylacetic acid or 3,4-dimethoxyphenylacetone sodium4732-70-1
263-(4'-Sulfonanilide)Bornand-2-he and its salts56039-58-8
274-Tert-butyl-4'-methoxydibenzoylmethane70356-09-1
282,2',4,4'-Tetrahydroxybenzophenone131-55-5
292,2'-Methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-TETRAMETHYLBUTYL)phenol]103597-45-1

RoomSubstanceRegistration number in Chemical Abstracts (acid)
302,2'-(1,4-Phenylene)bis-1 H-benzimidazole-4,6-disulfonate, sodium salt180898-3-7
312,4-Bis[4-(2-ethylhexyloxy)-2-hydroxy]phenyl--(4-methoxyphenyl)-(1,3,5)-triazine 187393-00-6
323-(4-Methylbenzylidene)camphor36861-47-9
33Complex polyethoxyethanol ether 4-bis(Polito-XI)-p-aminobenzoic acid113010-52-9
342,4-Dihydroxybenzophenone131-56-6
352,2'-Dihydroxy-4,4'-dimethoxybenzophenone-5,5'-distribulion3121-60-6
36Complex hexyl ester of 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoic acid302776-68-7
372-(2H-Benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]DISI-laksani]propyl]phenol155633-54-8
381,1-[(2,2'-DIMETHYLPROPANE)carbonyl]-4,4-diphenyl-1,3-butadiene363602-15-7

In addition to the above two groups of primary light protection substances is also possible to use secondary light protection agents of a type of antioxidant that is able to break the chain of photochemical reactions occur is when penetration of UV radiation into the skin. Their typical examples are superoxide dismutase, catalase, tocopherol (vitamin E) and ascorbic acid (vitamin C).

The other group consists protivovazdushna substances that have anti-inflammatory effect on UV damaged skin.

Such substances include, for example, bisabolol, phytyl side-chain and phytantriol.

The invention relates also to the use proposed in the invention, we accordingly proposed in the invention by the method of molecular imprinted active ingredient polymers in combination with a check UV rays inorganic pigments in dermocosmetics drugs. Preferred are pigments based on metal oxides and/or other difficultly soluble or water-insoluble compounds of metals selected from the group comprising zinc oxide (ZnO), titanium dioxide (TiO2), iron oxide (for example, Fe2O3), zirconium oxide (ZrO2), silicon dioxide (SiO2), manganese oxide (e.g., MnO), aluminum oxide (Al2O3), cerium oxide (e.g., CE2About3), mixed oxides of the corresponding metals and mixtures of these oxides.

Inorganic pigments can be provided with a coating, that is, may be subjected to surface treatment. Such surface treatment may state the point, for example, in supplying pigments thin hydrophobic surface coating, which is realized by a known method, for example, described in German patent application DE-A-3314742.

Suitable repellents are compounds that can scare away from a person certain animals, primarily insects. These include, for example, 2-ethyl-1,3-hexanediol, N,N-diethyl-m-toluamide and similar substances. Suitable hyperemesis active ingredients that increase blood flow to the skin, are, for example, essential oils such as pine stanec, lavender, rosemary, juniper, horse chestnut extract, birch leaf extract, extract of hay dust, ethyl acetate, camphor, menthol, peppermint oil, rosemary extract, eucalyptus oil and the like. Suitable substances with a keratolytic and keratoplasticheskie action are, for example, salicylic acid, thioglycolic calcium, thioglycolate acid and its salts, sulfur and so on. Suitable antiseborrheic active substances are, for example, sulfur, sulfur polyethylene glycol, sorbitan monooleate, the sulfur retinol polyethoxylate, zinc pyrithione, aluminum pyrithione and so on. Suitable anti-inflammatory active ingredients that prevent skin irritation, are, for example, allantoin, bisabolol, Drago-Sant is l, chamomile extract, panthenol, and the like.

In addition, the invention relates to the use proposed in the invention, we accordingly proposed in the invention by the method of molecular imprinted the active ingredient of the polymer in combination with at least one cosmetically or pharmaceutically acceptable polymer.

Suitable polymers are, for example, cationic polymers with the name according INCl (International nomenclature of cosmetic ingredients) Polyquaternium, e.g. copolymers based winhelper-rolidone and salts of N-vinylimidazole (Luviquat PC, Luviquat HM, Luviquat MS, Luviquat&commat, Care), copolymers based on N-vinylpyrrolidone and quaternionic diethylsulfate of dimethylaminoethylmethacrylate (Luviquat PQ 11), copolymers based on N-vinylcaprolactam, N-vinylpyrrolidone and salts of N-vinylimidazole (Luviquat E Hold), cationic cellulose derivatives (Polyquaternium-4, Polyquaternium-10), AK-aluminia copolymers (Polyquaternium-7) and chitosan.

Suitable cationic (quaternidinum) polymers are also Merquat (polymer-based chloride dimethyldiallylammonium), Gafquat (Quaternary polymers produced by the interaction of polyvinylpyrrolidone with Quaternary ammonium compounds), polymer JR (hydroxyethylcellulose with cationic groups) and cationic polymers based on vegetable raw materials, for example, guar on emery, such as Jaguar products®the company Rhodia.

Suitable are also neutral polymers, such as polyvinylpyrrolidone, copolymers of N-vinylpyrrolidone with vinyl acetate and/or fenilpropionata, polysiloxane, polyvinylcaprolactam and other copolymers with N-vinyl pyrrolidone, polyethyleneimine and their salts, poly-vinylamine and their salts, derivatives of cellulose, salt poliasparaginovaya acids and their derivatives. Such polymers include, for example, Luviflex 0 Swing (partially stylenny copolymer of polyvinyl acetate with polyethylene glycol BASF).

Suitable are water-soluble, respectively, water-dispersible nonionic polymers or oligomers, such as polyvinylcaprolactam, for example, Luviskol 0 Plus (BASF), polyvinylpyrrolidone and copolymers of vinylpyrrolidone primarily with complex vinyl esters such as vinyl acetate, for example, Luviskol 0 VA 37 (BASF), and polyamides, for example, based on the basis of itaconic acid and aliphatic diamines, see, for example, in German patent application DE-A-4333238.

In addition, are suitable amphoteric or zwitter-ionic polymers, such as copolymers based octylacrylamide, methyl methacrylate, tert-butylmethacrylate and 2-hydroxypropylmethacrylate, manufactured by National starch under the trade name Amphomer and zwitterionic polymer is, known, for example, from German patent DE 3929973, DE 2150557, DE 2817369 and DE 3708451. Preferred zwitter-ionic polymers are copolymers based on chloride of acrylonitrilebutadiene and acrylic or methacrylic acid and the corresponding alkali metal salts or ammonium. In addition, suitable zwitter-ionic polymers are copolymers of Methacrylonitrile with methacrylates, manufactured by the company AMERCHOL under the trade name Amersette®and copolymers based on hydroxyethylmethacrylate, methyl methacrylate, N,N-dimethylaminoethylmethacrylate and acrylic acid (Jordapon (D)).

Suitable are nonionic elexandria water-soluble or water-dispersible polymers, for example, polyethylsiloxane, such as Tegopren (company Goldschmidt) or Belsil (Wacker).

According to the invention using molecular imprinted polymers in combination with dermocosmetics active ingredients (one or more compounds), preferably selected from the group comprising acetylsalicylic acid, atropine, azulene, hydrocortisone and its derivatives, e.g. hydrocortisone-17-valerate, vitamins of groups b and D, especially vitamin B1, vitamin B12, vitamin D, vitamin a and corresponding derivatives, such as retinyl palmitate, vitamin E and its derivatives, such as tocope the Il acetate, vitamin C and its derivatives, such as ascorbicacid and nicotinamide, panthenol, bisabolol, polidocanol, unsaturated fatty acids such as essential fatty acids (commonly called vitamin F), first of all γ-linolenic acid, oleic acid, eykozapentaenovuyu acid, docosahexaenoyl acid and their derivatives, levomycetin, caffeine, prostaglandins, thymol, camphor, squalene, extracts and other products of vegetable and animal origin, e.g. evening primrose oil, borage oil or black currant oil, fish fats, health fish oil, ceramides and similar compounds, frankincense extract, green tea extract, extract of Lily white, licorice, witch hazel, antiseborrheic active substances (for example, selenium disulfide, sincerity, piroctone, alamin, climbazol, octopirox, polidocanol and their combinations), complex active ingredients, including, for example, γ-oryzanol and calcium salts, such as calcium Pantothenate, calcium chloride and calcium acetate. Preferred is also the choice of biologically active substances from the group comprising reducing the fat content of a substance, for example, Porcellino oil, Eucerit®and Neocerit®. In addition, especially if offered in the invention are preparations to ensure the prevention of the symptoms of aging, due to the internal state of the organism and/or the influence of external factors, as well as for treatment and prevention of harmful effects on the hair of ultraviolet radiation, the active substances are particularly preferably chosen from the group comprising inhibitors of NO-synthase. A preferred inhibitor of NO-synthase is nitroarginine. In addition, the active substances are preferably selected from the group including catechins, esters on the basis of Gallic acid and catechins and aqueous or organic extracts from plants or parts of plants, containing catechins or esters of Gallic acid and catechins, such as leaves of plants in the family Theaceae, first of all, Camellia sinensis (green tea). It is particularly preferred active substances are typical ingredients of these extracts (e.g., polyphenols, respectively catechins, caffeine, vitamins, sugars, minerals, amino acids and lipids). Catechins are a group of compounds that can be considered as hydrogenated flavones or anthocyanidins and which are derivatives of catechin (catechol, 3,3',4',5,7-flowerpetal, 2-(3,4-dihydroxyphenyl)-chroman-3,5,7-triol). In accordance with the present invention the preferred active ingredient is also epicatechin [(2) - Rev.,3S)-3,3',4',5,7-flowerpetal]. Preferred are also contains catechins, plant extracts, first of all, green tea extracts, such as extracts from leaves of plants of the species Camellia spec., in particular teas Camellia sinenis, .assamica, .taliensis or .inawadiensis and related hybrids, for example, Japanese Camellia (Camellia japonica). In addition, the preferred active substances are polyphenols, respectively catechins selected from the group comprising (-)-catechin, (+)-catechin, (-)-catechingallat, (-)-allocatedirect, (+)-epicatechin, (-)-epicatechin, (-)-epicatechol, (-)-epigallocatechin and (-)-epigallo-catechingallat.

In addition, in accordance with the present invention the preferred active substances are flavone and its derivatives (often also called "flavones"). Such substances have the following basic structural formula (including the provisions of deputies):

Table 7 summarizes some of the more important flavones, which preferably can also be used in the proposed invention the drugs.

Table 7
Flavones
P is the position of hydroxyl substituents
35782'3'4'5'
Flavon--------
Flavonol+-------
Chrisen-++-----
Galangin+++-----
Apigen is n -++---+-
Fisetin+-+--++-
Luteolin-++--++-
Kemperol+++---+-
Quercetin+++--++-
Maureen+ ++-+-+-
Robinets+-+--+++
Gossipteen++++-++-
Myricetin+++--+++

In nature, flavones, usually found in glucosideuronic form.

According to the invention, the flavonoids are preferably chosen from the group comprising compounds of General formula:

,

in which Z1-Z7mean substituents, independently from each other selected from the group comprising hydrogen, hydroxyl group, and is coxi, hydroxyalkoxy, can be branched and unbranched and can contain from 1 to 18 carbon atoms, means Gly residue selected from the group comprising monoglycoside and oligoglycosides remains.

Along with these active ingredients (one or more compounds), even more preferably may be selected from the group primarily includes the following hydrophilic connection:

α-hydroxy acid such as lactic or salicylic acid, respectively, and their salts, such as sodium lactate, calcium lactate, lactate triethanolamine, urea, allantoin, serine, sorbitol, glycerin, milk proteins, panthenol and chitosan.

According to the invention the content of the above active ingredients (one or more compounds) in the preparations is preferably from 0.001 to 30 wt. -%, particularly preferably from 0.05 to 20 wt. -%, first of all, from 1 to 10% of the mass. in terms of the total weight of the preparation. These and other active substances that can be used in the proposed invention the drugs listed on pages 12-17 of the German patent application DE 10318526 A1, which is in full should be considered an appropriate reference.

In addition, the present invention relates to the use of the above drugs to prevent unwanted changes in appearance of the skin, for example, such as acne, oily skin, keratoses and red acne, and skin sensitivity to light and the occurrence of inflammatory, erythematous, allergic or autoimmune reactions.

Under proposed in the invention means preferably involve remedies skin care products skin cleansing the skin, remedies hair, hair care products, detergents, hair products for hair coloring, dental elixirs, rinse mouth or preparations for decorative cosmetics, which, depending on destination preferably used in the form of ointments, creams, emulsions, suspensions, lotions, milk, pastes, gels, foams or sprays.

Proposed in the invention of cosmetics in addition to the proposed invention, we accordingly proposed in the invention by the method of molecular imprinted active ingredient polymers can also contain any of the above polymers, pigments, stabilizers, moisture, oils, waxes, enzymes, mineral supplements, vitamins, sunscreen agents, dyes, fragrances, antioxidants, preservatives and/or pharmaceutical active substances.

Proposed in the invention cosmetics also have the following features.

Basic formulation proposed in the invention is of rest preferably includes a cosmetically or dermocosmetics/pharmaceutically acceptable excipients. Under them mean excipients that are acceptable for use in pharmaceutical industry, food technology and related fields, primarily published in the relevant prescription books (e.g., DAB Ph. Eur. BP NF), and other excipients, properties which allow their physiological use.

Appropriate excipients can be lubricants, wetting agents, emulsifying and suspendresume tools, preservatives, antioxidants, anti-irritation, hepatoblastoma substances, stabilizers of emulsions, binders, gelling agents, means for masking the smell, resins, hydrocolloids, solvents, soljubilizatory, neutralizing agents, penetration accelerators, pigments, Quaternary ammonium compounds, means for lowering and raising the fat content, the source components for ointments, creams or oils, silicone derivatives, stabilizers, sterilizing agents, propellants, drying agents, means to impart opacity, thickeners, waxes, plasticizers and vaseline oil. These components known in the art and are, for example, in the Handbook Fiedler, H.P., Lexikon der Hilfsstoffe fur Farmazie, Kosmetik und angrenzende Gebiete, 4th edition, Aulendorf, publisher ECV-Editio-Kantor, 1996.

With the goal of manufacturing is the service offered in the invention dermocosmetics means active substances can be mixed with suitable auxiliary substance (vehicle) or dilute the substance. Auxiliary means may be solid, semi-solid or liquid materials, and can serve as indifferent or medium for the active substance. Known in the art methods, if necessary, add other excipients. In addition, polymers and dispersions suitable for use as an aid in the pharmaceutical industry, and it preferably is about their use as coating materials or binders for solid dosage forms. They can also be used in creams and as a coating or binder in the manufacture of tablets.

In another preferred embodiment, under proposed in the invention means imply cosmetics, skin care and hair care, as well as for their protection, tools for nail care and preparations for decorative cosmetics.

Suitable cosmetic products for skin care are, for example, free water, cream, face masks, deodorants and other cosmetic lotions. By means of decorative cosmetics include, for example, protective pencils, theatrical cosmetics, ink and dye for eyelashes and eyebrows, eyeshadow, lipstick, pencils to create contour on the inner eyelid, brushes and pencils for drawing a contour line in the CI around the eyes, blushers, powders and eyebrow pencils.

In addition, molecular imprinted polymers can be used in Nose strips-Strips for pore cleansing, remedies for acne, insect repellents, means for care of the skin before and after shaving, means after tanning, tools for hair removal, tools for hair coloring, means of personal hygiene, tools for pedicure, as well as in children's cosmetics.

Under proposed in the invention means for skin care primarily involve creams of the type "water in oil" or "oil-in-water, day and night creams, creams for eyes, face creams, anti-wrinkle creams, sunscreen creams, moisturizing creams, bleaching creams, sun creams, vitamin creams, skin lotions and lotions for skin care and moisturizing.

In addition, with the aim of protecting the skin and/or hair against oxidative processes and the resulting aging process or violation of the structure of the proposed invention in cosmetic and dermatological products in addition to the proposed invention, we accordingly proposed in the invention by the method of molecular imprinted active ingredient polymers may contain decaying into radicals active substance. Under such active substances preferably mean connect the tion, known from international application WO/0207698 and WO/03059312 (these publications should be considered relevant links), and preferred are those described in these boron-containing compounds capable of restoring the peroxides or hydroperoxides to the corresponding alcohols without the intermediate stages of the formation of radicals. Along with this, for the above purpose, you can use spatial employed amines of General formula:

in which

Z denotes hydrogen, alkyl group with 1-22 carbon atoms, preferably 1-12 carbon atoms, such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, mpem-butyl, pentyl, isopentyl, neopentyl, tert-pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl or dodecyl, CNS group with 1-22 carbon atoms, preferably 1-12 carbon atoms, such as Alcock-dimetil, alkoxyethyl, alkoxyaryl, alkoxyethanol, almaximo-Thiel, alkoxyethyl, alkoxy-sec-butyl, alkoxy-tert-butyl, al-accipietis, alkoxyethanol, alkoxymethyl, alkoxy-tert-pentyl, alkoxyalkyl, alkoxyaryl, alkoxyalkyl, alkoxy-nonyl, alkoxyaryl, alkoxyphenyl or alkoxymethyl, aryl puppu with 6-10 carbon atoms, such as phenyl or naphthyl, and phenyl residue may be substituted by alkyl residues with 1 to 4 atoms ug is erode, or 0-aryl group with 6-10 carbon atoms which may be substituted by alkyl or CNS group with 1-22 carbon atoms, preferably alkyl or CNS group with 1-12 carbon atoms, such as above,

R1-R6 independently of one another denote hydrogen, hydroxyl group, oxygen, alkyl group with 1-22 carbon atoms, preferably 1-12 carbon atoms, such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-butyl, pentyl, out-of pencil, neopentyl, tert-pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl or dodecyl, CNS group with 1-22 carbon atoms, preferably 1-12 carbon atoms, such as Alcock-dimetil, alkoxyethyl, alkoxyaryl, alkoxyethanol, almaximo-Thiel, alkoxyethyl, alkoxy-sec-butyl, alkoxy-tert-butyl, approximatel, alkoxyethanol, alkoxymethyl, alkoxy-tert-pentyl, alkoxyalkyl, alkoxyaryl, alkoxyalkyl, alkoxy-nonyl, alkoxyaryl, alkoxyphenyl or alkoxymethyl, aryl group with 6-10 carbon atoms, such as phenyl or naphthyl, and phenyl residue may be substituted by alkyl residues with 1 to 4 carbon atoms, or O-aryl group with 6-10 carbon atoms which may be substituted by alkyl or CNS group with 1-22 carbon atoms, preferably alkyl or CNS gr is POI with 1-12 carbon atoms, such as stated above.

Especially preferred is the use as a spatial difficult amines 3-dodecyl-N-(2,2,6,6-tetramethyl-4-piperidinyl)succinimide, 3-dodecyl-N-(1,2,2,6,6-pentamethyl-4-piperidinyl) succinimide, 3-octyl-N-(2,2,6,6-tetramethyl-4-piperidinyl)succin-imide, 3-octyl-N-(1,2,2,6,6-pentamethyl-4-piperidinyl)succinimide, 3-octenyl-N-(2,2,6,6-tetramethyl-4-piperidinyl)succinimide, 3-octenyl-N-(1,2,2,6,6-pentamethyl-4-piperidinyl)succinimide and/or product Uvinul®N, the contents of which are calculated on the total weight of tools ranges from 0.001 to 1 wt. -%, preferably from 0.01 to 0.1% of the mass. or from 0.1 to 1% of the mass.

Cosmetic preparations for skin care in addition to the above proposed in the invention compounds and the corresponding bases may also contain other above active and excipients usually used in these cosmetics. To them preferably include emulsifiers, preservatives, perfume oils, cosmetic active ingredients, such as phytantriol, vitamins a, E and C, retinol, bisabolol, panthenol, light shielding means, bleaches, colorants, tinting tools, tools to simulate tanning, collagen, protein hydrolysates, stabilizers, regulators, pH, dyes, salts, thickeners, gelling agents, R is gulatory consistency, silicones, means for stabilizing the moisture content of the skin, means for recovery of skin and/or other commonly used additives.

Preferred oil and fat components of cosmetic and dermocosmetics funds are above mineral and synthetic oils, such as paraffin, silicone oil, aliphatic hydrocarbons having a number of carbon atoms greater than eight, oils of animal or vegetable origin, such as sunflower oil, coconut oil, avocado oil and olive oil, lanolin, wax, fatty acids, esters of fatty acids, such as triglyceride-based fatty acids with 6-30 carbon atoms, esters of waxes such as jojoba oil, aliphatic alcohols, vaseline, hydrogenated lanolin and acetylated lanolin, as well as the appropriate mixtures.

For the production of cosmetic and dermocosmetics drugs with certain properties, such as the ability to provide a pleasant feeling when Petrasiunai to the skin, the uniform distribution, the resistance and/or the binding of active substances and additives, such as pigments, their composition optionally you can also enter the conditioning substances based on silicone compounds.

Th is DNAME organosilicon compounds are, for example, polyallylamine, polyacrilamide, polyallylamine, polyethylsiloxane or silicone resin.

The manufacture of cosmetic or dermocosmetic drugs carry the usual, known in the art methods.

Beauty and cosmetics are preferably in the form of emulsions, first of all, emulsions water in oil or oil-in-water.

However, this does not exclude the possibility of selecting songs of other type, for example, aqueous dispersions, gels, oils, oleogels, multi-component emulsion, for example, emulsions of the type water/oil/water or oil/water/oil, anhydrous ointments, respectively ointment bases, and the like. Preferred are also not contain emulsifiers compositions, such as hydro-dispersion, hydrogels or emulsion of Pickering.

According to the invention emulsions can be manufactured by known methods. In addition to the at least one molecular imprinted polymer and water emulsions generally contain conventional components such as aliphatic alcohols, esters of fatty acids, primarily triglycerides of fatty acids, fatty acids, lanolin and its derivatives, natural or synthetic oils, waxes and emulsifiers. For selecting the proper supplements specific for emulsions of this type, and cooking with the corresponding emulsions can be used for example, the information in the handbooks Schrader, Grundlagen und Rezepturen der Kosmetika, publisher HOthig Buch Verlag, Heidelberg, 2nd edition, 1989, part 3, and Umbach, Kosmetik: Entwicklung, Herstellung und application kosmetischer Mrttel, 2nd revised edition, 1995, Georg Thieme, ISBN 313 712602 9, 122 and following that should be considered relevant links.

Emulsion type water in oil", suitable for the manufacture of creams for skin care and the like, in the General case contains the aqueous phase, which through appropriate emulsifying system is distributed in the oil or fat phase. To prepare the aqueous phase, you can use the polyelectrolyte complex.

Preferred fatty components that may be present in the fatty phase of the emulsions, are hydrocarbon oils such as paraffin oil, Porcellino oil, perhydrosqualene and solutions of microcrystalline waxes in these oils; oils of animal or vegetable origin such as almond oil, avocado oil, oil parthenium, lanolin and its derivatives, castor oil, sesame oil, olive oil, str, butter, Shea butter or oil hoplostethus; mineral oil, which in the conditions of distillation at atmospheric pressure boiling in the approximate temperature range of from 250 to 410°C., such as vaseline oil; SL is the author esters of saturated or unsaturated fatty acids, such as alkalinity, for example, isopropylmyristate, Boutilimit, cetilistat, gexadezilfosfat, Etisalat, isopropyl, triglyceride octane or decanoas acid and cetirizine.

The fatty phase may also contain soluble in other oils silicone oils, such as dimethylpolysiloxane, methylphenylpolysiloxane and a copolymer of siliconvalley, as well as fatty acids and aliphatic alcohols.

In addition to the above proposed invention the connection means for skin care can also contain waxes, such as Carnauba wax, kandellilsky wax, beeswax, microcrystalline wax, ozokerite, as well as the oleates, myristate, linoleates and stearates of calcium, magnesium or aluminium.

Proposed in the invention, the emulsion may be in the form of a system of the type oil-in-water". Such emulsion typically contains an oil phase, an emulsifier used to stabilize the oil phase in the aqueous phase, and is usually located in the thickened water phase. As emulsifiers preferably used emulsifiers for emulsion of the type oil-in-water, such as esters of polyglycerol, esters sorbitan or partially esterified glycerides.

In another preferred embodiment, under proposed in the invention means under somewhat shower gels, shampoos or preparations for baths, and especially preferred are preparations with light protection additives.

Compositions of this type contain at least one proposed in the invention, according to the proposed invention by molecular imprinted active ingredient of the polymer, at least one ampholytic copolymer, and usually anionic surfactants as base surfactants and amphoteric and/or nonionic surfactant as an additional surfactant. Other suitable active and/or auxiliary substances in the General case selected from the group comprising lipids, perfume oils, dyes, organic acids, preservatives, antioxidants, and thickeners, gelling agents, means conditioning the skin and means for stabilizing its moisture content.

Such compositions predominantly contain from 2 to 50 wt. -%, preferably from 5 to 40 wt. -%, particularly preferably from 8 to 30% of the mass. Surfactants in terms of the total weight of the composition.

The composition of detergents and products for shower or bath may include any commonly used means of body care anionic, neutral, amphoteric or cationic surfactant.

Suitable anionic surfactants are, for example, alkyl sulphates. alkyl-sulfonic ethers, alkyl sulphonates, alkylaryl honety, alkylacrylate, alkylsulfonate, N-allylcarbamate, allcounty, arylisocyanate, alkylphosphate, alkylphosphate, alkylaminocarbonyl and alpha reincorporate, primarily salts of alkali and alkaline earth metals, e.g. sodium, potassium, magnesium or calcium, and ammonium salts, and triethanolamine. Alkylsulfonates, alkylphosphates and alkylaminocarbonyl can contain from 1 to 10 ethylenoxide or propylenoxide structural units, preferably from 1 to 3 ethylenoxide structural units in the molecule.

Suitable anionic surfactants include, for example, lauryl sulfate, lauryl ammonium, laurylsulphate sodium, laurylsulphate ammonium, laurylsarcosine sodium, oleylamine sodium, laurylsulphate ammonium, dodecylbenzenesulfonate sodium and triethanolamine-dodecylbenzensulfonate.

Suitable amphoteric surfactants are, for example, alkylbetaine, alkylamidopropylbetaine, alkylsulfonates, allylglycine, alkyl-carboxyglutamate, alkylamidoamines, alkylamidoamines, alkyl-apodicticity and alkylamidoamines.

So, for example, as amphoteric surfactants can be used cocody-methylsulfonylmethan, laurylether, cocamidopropylbetaine or cocomponent sodium.

Suitable nonionic surfactants are, for example, the products of the interaction of Ali is oticheskih alcohols or alkyl phenols with 6 to 20 carbon atoms in the alkyl chain, which may be unbranched or branched, with ethylene oxide and/or propylene oxide. The number of accelerated is about from 6 to 60 moles per mole of alcohol. In addition, suitable nonionic surfactants are alkylamines, mono-alkylethanolamine, dialkylacrylamide, esters based on fatty acids and polyethylene glycol, ethoxylated amides of fatty acids, alkylpolyglycoside or esters sorbitan.

In addition, washing preparations and preparations for the shower and bath can contain customary cationic surfactants, such as Quaternary ammonium compounds, for example, chloride, cetyltrimethylammonium.

Recipe shower gels and shampoos can also contain thickeners, such as sodium chloride, peg-55, propylene glycol the oleate, peg-120-methylglucose dioleate and others, as well as preservatives, and other active and auxiliary substances and water.

Means for processing hair

According to another preferred variant under proposed in the invention dermocosmetics means imply preparations for the treatment of hair.

Proposed in the invention means for processing the hair preferably are in the form of a spray, a foam retainer, mousse, gel, shampoo, bubble hair, spray liquid, means time is of animania for perms, means for dyeing or bleaching hair or oil preparation for a hot hair. Depending on the specific purpose of cosmetic preparations for hair treatment can be used in the form of a spray, aerosol foam, mousse, gel, gel spray, cream, lotion or wax. Under the spray mean as an aerosol drug and drug manual spraying (without propellant). Foam hair can be as aerosol drug and drug manual application (without propellant). Sprays and foams for hair preferably predominantly or exclusively water-soluble or water-dispersible components. In the case of use in the proposed invention the sprays and foams for hair water-dispersible compounds of the latter can be applied in the form of water microdisperse with a particle size typically in the range from 1 to 350 nm, preferably from 1 to 250 nm. Thus, the solids content of such drugs is usually located in the approximate range from 0.5 to 20% wt. The need to use any emulsifiers or surfactants to stabilize these microdisperse, as a rule, is absent.

Under other components are usually meant to be used in cosmetic preparations additives, for example, about alenty, antispyware, surfactants, emulsifiers, foaming agents and solubilization. Used surfactants can be anionic compounds, cationic, amphoteric or neutral type. Other conventional components include, for example, preservatives, perfume oils, means to impart opacity, active ingredients, UV filters, substances for hair care, such as panthenol, collagen, vitamins, protein hydrolysates, alpha - and beta-hydroxycarbonate acid, stabilizers, regulators, pH, dyes, viscosity regulators, gel-forming agents, salts, means for stabilizing the moisture content, the means to restore fat, complexing agents and other commonly used additives.

In addition, other components include any of the cosmetic sphere styling and conditioning polymers that can be used in combination with molecular imprinted polymers, if cosmetic preparations should be given special properties.

As polymers commonly used in cosmetics for hair, suitable, for example, the abovementioned cationic, anionic, neutral, non-ionic and amphoteric polymers.

According to the invention to give the cosmetic preparations of certain properties in the composition is optional, you can also enter the conditioning substances based on silicone compounds. Suitable silicone compounds are, for example, poly-alkylsilane, polyacrilamide, polyallylamine, poly-afirican, silicone resin or Dimethicone copolyol (named according to the nomenclature of the CTFA - Association of perfumery and cosmetic products and fragrances) and amidofunctional organosilicone compounds, such as amodimethicone (CTFA).

According to the invention suitable propellants are commonly used in sprays and aerosol foam hair working gases. Preferred propellants are mixtures of propane to butane, pentane, dimethyl ether, 1,1-differetn (HFC-152), carbon dioxide, nitrogen, or compressed air.

As emulsifiers can use any emulsifiers, usually included in the pen for volosin emulsifiers are compounds of non-ionic, cationic, anionic or amphoteric type. Examples of nonionic emulsifiers are the winners (range INCl), for example, Laureth-4, satety, for example, ceteth-1, polietilenglikolya esters, clearly, for example, ceteareth-25, glycerides polyglycolic acids, gidroksilirovanii lecithin, lactylate esters of fatty acids or alkylpolyglycoside.

Examples of suitable cationic emulsifiers are dihydrophosphate acidimeter-2-hydroxyethylamine, Cetelem nilore, cameltry-monobromide, locationideally and series products Quaternium (Quatemium-1 to Quaternium-x in accordance with the nomenclature INCl).

Anionic emulsifiers are, for example, can be selected from the group comprising alkyl sulphates, alkylsulphonates, alkyl sulphonates, alkyl-arylsulfonate, alkylacrylate, alkylsulfonate, N-alkyl-sarcosinate, allcounty, utilizationin, alkylphosphate, alkyl ester-phosphate, alkylaminocarbonyl, alpha reincorporate, primarily salts of alkali and alkaline earth metals, e.g. sodium, potassium, magnesium, calcium and ammonium salts, and triethanolamine. Alkylsulfonates, alkylphosphates and alkylaminocarbonyl can contain from 1 to 10 units of ethylene oxide or propylene oxide, preferably from 1 to 3 structural units of ethylene oxide in the molecule.

As gelling agents can be used any funds of this type, usually used in cosmetic preparations. To fit heleonastes is weakly crosslinked polyacrylic acid, for example carbomer (INCI nomenclature), cellulose derivatives, e.g. hydroxypropylcellulose, hydroxyethylcellulose or cation-modified cellulose, polysaccharides, e.g. xanthan gum, Caprylic/capric triglyceride, copolymers of materialrelated, Polyquaternium-32 (and) Paraffinium Liuidum (range INCl), copolymers of materialrelated (and) Paraffinium Liquidum (and) polypropylenglycol-1 Trideceth-6, copolymers of acrylamidophenylboronic-chloride/acrylamide, steareth-10 allyl ether, copolymers of acrylates, Polyquaternium-37 (and) Paraffinium Liquidum (and) polypropylenglycol-1 Trideceth-6, Polyquaternium 37 (and) propilenglikolmonostearata (and) polypropylenglycol-1 Trideceth-6, Polyquaternium-7 and Polyquaternium-44.

According to the invention the formulations of shampoos can contain any commonly used in shampoos, anionic, neutral, amphoteric or cationic surfactant.

Suitable anionic surfactants are, for example, alkyl sulphates, alkyl-sulfonic ethers, alkyl sulphonates, alkylarylsulphonates, alkylacrylate, alkylsulfonate, N-allylcarbamate, allcounty, utilizationin, alkylphosphate, alkylphosphate, alkylaminocarbonyl, alpha reincorporate, primarily salts of alkali and alkaline earth metals, e.g. sodium, potassium, magnesium, calcium and ammonium salts, and triethanolamine Alkylsulfate, alkylphosphate and alkylaminocarbonyl can contain from 1 to 10 units of ethylene oxide or propylene oxide, preferably from 1 to 3 structural units of ethylene oxide in the molecule.

Suitable anionic surfactants are, for example, lauryl sulfate, lauryl ammonium, laurylsulphate sodium, laurylsulphate ammonium, laurylsarcosine NAT the Oia, oleylamine sodium, laurissl-focaccina ammonium, dodecylbenzenesulfonate sodium, triethanolamine-dodecylbenzensulfonate.

Suitable amphoteric surfactants are, for example, alkylbetaine, alkylamidopropylbetaine, alkylsulfonates, allylglycine, alkyl-carboxyglutamate, alkylamidoamines, alkylamidoamines, alkyl-apodicticity and alkylamidoamines.

So, for example, as amphoteric surfactants can be used cocody-methylsulfonylmethan, laurylether, cocamidopropylbetaine or cocomponent sodium.

Suitable nonionic surfactants are, for example, the interaction products of aliphatic alcohols or alkyl phenols with 6 to 20 carbon atoms in the alkyl chain, which may be unbranched or branched, with ethylene oxide and/or propylene oxide. The number of accelerated is about from 6 to 60 moles per mole of alcohol. In addition, suitable nonionic surfactants are alkylamines, monoalkanolamines, dialkylacrylamide, esters based on fatty acids and glycols, alkylpolyglycoside or esters sorbitan.

The formulations of shampoos may also comprise customary cationic surfactants, such as Quaternary ammonium compounds, in particular, cetyltrimethylammoniumbromide.

To achieve certain effects in recipes Sha is a Punia, you can use regular conditioning agents in combination with a molecular imprinted polymer.

Suitable conditioning agents are, for example, the abovementioned cationic polymers according to the nomenclature INCl called Polyquaternium primarily copolymers based on vinylpyrrolidone and salts M-vinylimidazole (Luviquat FC, Luviquat HM, Luviquat MS, Luviquat Care), copolymers based on N-vinylpyrrolidone and quaternionic diethylsulfate of dimethylaminoethylmethacrylate (Luviquat D PQ 11), copolymers based on N-vinylcaprolactam, N-vinylpyrrolidone and salts of N-vinylimidazole (Luviquat D Hold), cationic cellulose derivatives (Polyquaternium-4, Polyquaternium-10), and copolymers of acrylamide (Polyquaternium-7). In addition, you can use protein hydrolysates, as well as the conditioning substances based on silicone compounds, for example, polyallylamine, polyacrilamide, poly-arylalkylamine, polyethylsiloxane or silicone resin. Other suitable organo-silicon compounds are Dimethicone copolyol (CTFA) and amidofunctional organosilicone compounds, such as amodimethicone (CTFA). You can also use cationic derivatives of the guar resin, such as qualitatsprufer-trionychid (INCl).

According to another variant of the invention, the above cosmetic products are used for skin care or hair and for their protection, and thus are in the form of an emulsion, disperse and, suspension, aqueous surfactant preparation, a milk, a lotion, cream, balm, ointment, gel, granules, powders, preparations in the form of a pencil, for example, such as lipstick, as well as in the form of a foam, an aerosol or spray. Such formulations are particularly well suited for preparations for topical use. Suitable emulsions are systems of type oil-in-water" and "water in oil" or microemulsions.

The similar product for skin care or hair, as a rule, is intended for topical application to the skin or for use on the hair. Under the drugs topical application refers to a composition suitable for uniform distribution of the active substances on the skin and their optimal absorption after application. This ability to have, for example, aqueous or hydroalcoholic solutions, sprays, foams, foam aerosols, ointments, aqueous gels, emulsions of the type oil-in-water" and "water in oil"microemulsion or cosmetic preparations in the form of pencils.

In a preferred embodiment of the proposed invention in cosmetic products contain a basis. Suitable base preferably is water, gas, water-based liquid, oil, gel, emulsion, microemulsion, dispersion, or their mixture. These bases have the best ability to spread on the skin. The quality of local products, especially the military, preferably using aqueous gels, emulsion or microemulsion.

As emulsifiers can be used nonionic, zwitter-ionic, ampholytic or anionic surfactants. The content of the emulsifier in the proposed in the invention compositions can comprise from 0.1 to 10 wt. -%, preferably from 1 to 5% of the mass. in terms of composition.

As nonionic surfactants can be used, for example, at least one compound selected from the group comprising the following substances:

the addition products of 2 to 30 moles of ethylene oxide and/or 0 to 5 moles of propylene oxide to an unbranched aliphatic alcohols with 8-22 carbon atoms, fatty acids with 12-22 carbon atoms or alkyl phenols with 8 to 15 carbon atoms in the alkyl group;

complex monetary and diesters based on fatty acids with 12-18 carbon atoms and products joining from 1 to 30 moles of ethylene oxide to glycerol; compound monetary and diesters based on glycerin or sorbitan and saturated or unsaturated fatty acids with 6 to 22 carbon atoms and addition products of ethylene oxide to these esters;

alkylhalogenide and alkylpolyglycoside with 8-22 carbon atoms in the alkyl residue and their ethoxylated analogs; the addition products of 15 to 60 moles of ethylene oxide to castor oil and/or otverzhdennom castor oil; esters of polyhydric alcohols, first su is th polyglycerol, for example, such as polyglycerylmethacrylate, polyglyceryl-12-hydroxystearate or polyglycidylether; suitable are mixtures of several compounds of a given class;

the addition products of 2 to 15 moles of ethylene oxide to castor oil and/or otverzhdennom castor oil;

partial esters based on an unbranched, branched, unsaturated, respectively saturated fatty acids with 6 to 22 carbon atoms, ricinoleic acid, and 12-hydroxystearate acid and glycerol, polyglycerol, pentaerythritol, dipentaerythritol, sugar alcohols (e.g. sorbitol), Alkylglucoside (for example, methyl glucoside, butylpyrazine, laurelhurst)and polyglucosides (for example, cellulose); monocalciumphosphate, dialkylphosphate and three-alkylphosphate, and mono-, di - and/or thepoliticalcarnival.net and their salts;

alcohols wool wax;

the copolymers with the structure of polysiloxane-polyalkyl-simple polyester, respectively derivatives thereof;

mixed esters on the basis of pentaerythritol, fatty acids, citric acid and aliphatic alcohol according to German patent DE PS 1165574 PS and/or mixed esters based on fatty acids with 6 to 22 carbon atoms, methylglucose and polyols, preferably glycerol or polyglycerol, and polyalkylene glycols.

In addition, as emulsifiers can be used zwitter-ionic surfactant. Zwitter-ionic surfactants referred to as surface-active substances whose molecules contain at least one Quaternary ammonium group and at least one carboxylate or one sulphonate group. Especially suitable zwitter-ionic surfactants are the so-called betaines, such as N-alkyl-N,N-dimethylaminopyridine, for example, cocoalkylamine, N-acylaminoacyl-N,N-dimethylaminopyridine, for example, chocolatedippedkate-amineptine, and 2-alkyl-3-carboxylmethyl-3-hydroxymethylimidazole with 8-18 carbon atoms, respectively, in the alkyl or acyl group, and chocolatechipcookierecipe. Especially preferred zwitter-ionic surfactant is derived amide of fatty acid, which according to the nomenclature of the CTFA called cocamidopropyl betaine.

Suitable emulsifiers are also ampholytic surfactants. Under ampholytic surfactants mean surface-active substances whose molecules in addition to the alkyl or acyl group with 8-18 carbon atoms contains at least one free amino group and at least one carboxyl or alphagroup and which are capable of forming internal salts, Examples of suitable ampholytic surfactants are N-and cyclizine, N-alkylphosphonate acid, N-alkylamino-butyric acid, N-alkylenediamine acid, N-hydroxy-ethyl-N-alkylamidoamines, N-alkyltin, N-acylcarnitine, 2-alkylenediamine acid and alkylaminocarbonyl acid, respectively containing about 8 to 18 carbon atoms in the alkyl group.

Particularly preferred ampholytic surfactants are N-cocoalkyl-aminopropionic, chocolateeeeeeeeeeeeeee and azilsartan with 1-18 carbon atoms. In addition to the ampholytic surfactants can also be used Quaternary emulsifiers, particularly preferred compounds of this type are exterkate, preferably quaternion the stands salts of esters of dibasic fatty acid and triethanolamine. In addition, as anionic emulsifiers can be used alkylsulfonates, monoglycerides, sulfates of fatty acids, sulfosuccinates and/or Abercrombie acid.

As oil environment can be used aliphatic alcohols Emblem with 6-18 carbon atoms, preferably 8-10 carbon atoms, esters on the basis of an unbranched fatty acid with 6 to 22 carbon atoms and unbranched aliphatic alcohols with 6 to 22 carbon atoms, esters based on branched carboxylic acids with 6 to 13 carbon atoms and unbranched aliphatic alcohols with -22 carbon atoms, esters based on an unbranched fatty acid with 6 to 22 carbon atoms and branched alcohols, especially 2-ethylhexanol, esters on the basis of unbranched and/or branched fatty acids and polyhydric alcohols (such as propylene glycol, dimer diol or trimer of triol) and/or alcohols Emblem, the triglyceride-based fatty acids with 6-10 carbon atoms, a liquid mixture of monoglycerides/diglycerides and triglycerides based on fatty acids with 6 to 18 carbon atoms, esters on the basis of aliphatic alcohols with 6 to 22 carbon atoms and/or alcohols Arms and aromatic carboxylic acids, first of all, benzoic acid, esters on the basis of dicarboxylic acids with 2 to 12 carbon atoms and is unbranched or branched alcohols with 1-22 carbon atoms or polyols with 2 to 10 carbon atoms and 2-6 hydroxyl groups, vegetable oils, branched primary alcohols, substituted derivatives of cyclohexane, the carbonate-based non-branched aliphatic alcohols with 6 to 22 carbon atoms, carbonates based alcohols Emblem, esters on the basis of benzoic acid and unbranched and/or branched alcohols with 6 to 22 carbon atoms (for example, product Finsolv®TN), dialkyl ethers, the products of interaction with the disclosure cycle epoxydecane esters of fatty acids with mnogoe the Ohm alcohols, silicone oils and/or aliphatic, respectively naphthenic hydrocarbons. As oil environment can also be used organosilicon compounds, for example, dimethylpolysiloxane, methylphenylpolysiloxane or cyclic silicones, and silicone compound modified with amino groups, groups of fatty acids, alcohols or polyether, epoxy fappani, fluorine atoms, alkyl and/or glycosidic groups, which at room temperature can be either in liquid or in a resinous state. The oil content of the environment proposed in the invention means may comprise from 1 to 90 wt. -%, preferably from 5 to 80% of the mass. and especially from 10 to 50 wt%. in terms of composition.

The list of possible ingredients of cosmetics, obviously, not limited to the above substances. The ingredients can be used individually or in any combination with each other.

Examples

Example 1. Synthesis of molecular imprinted polymers with α-tocopherol as a template

Option a)

Used HWS-reactor with a volume of 2 l, equipped with a refrigerator, anchor agitator with motor, fitting for nitrogen supply with a glass filter, laboratory temperature controller Julabo LC 3 sensors 2-RT-100, oil bath with preparing the NYM heater and magnetic stirrer, and two HPLC pumps company Bischoff with valve box (0-1 ml/min) dosing of initiator and monomers. Before performing the experiment, the apparatus was purged with nitrogen. During the whole experiment through a solution of missed nitrogen with a flow rate of about 10 l/h In the reaction vessel was loaded with 800 ml of solvent (acetonitrile), which was dissolved to 17.25 g of α-tocopherol (template).

Prepared additional solution 6,12 g of methacrylic acid and 73,51 g trimethylolpropane in 250 ml of acetonitrile (solution 1). 1 ml of this solution were taken for subsequent analysis by HPLC. Half of the rest of the solution 1 was added to loaded in the reactor and composition was carried out by stirring at the speed of the stirrer at 100 rpm, the reactor was selected sample volume of 1 ml for analysis by HPLC.

Into the reactor was introduced a fourth part (0,532 g) from the total amount of initiator and after performed at intensive stirring and dissolving the initiator has selected the sample volume of 1 ml for analysis by HPLC.

In the reactor the mixture was heated with stirring to a temperature of 75°C and was again selected a sample volume of 1 ml.

By dissolving the remaining 3/4 of the initiator of 1.594 g) in 250 ml Aceto-nitrile was preparing another solution (solution 2).

Within 18 hours by the corresponding HPLC-pumps in re ctor they dosaged the other half of the solution 1, as well as solution 2. Speed lizirovania solution 1 was 0,153 ml/min, a solution of 2 0,232 ml/min

The duration of the subsequent reactions was 6 hours, that is, the total reaction time was 24 hours. Through every hour of the reactor was selected sample of the reaction mixture in a volume of 1 ml, which after filtration was analyzed by HPLC method.

Upon completion of the polymerization, the polymer slurry was discharged from the reactor and filtered through a suction filter. The filter residue was washed with two portions of acetonitrile volume of 100 ml and was dried in vacuum at 50°C.

Option b)

Used HWS-reactor with a volume of 2 l, equipped with a refrigerator, anchor agitator with motor, fitting with glass filter for nitrogen supply, laboratory temperature controller Julabo LC 3 sensors 2-RT-100, oil bath with immersion heater and magnetic stirrer. Before performing the experiment, the apparatus was purged with nitrogen. During the whole experiment through a solution of missed nitrogen with a flow rate of about 10 l/h Into a reaction vessel were loaded 1000 ml solvent (acetonitrile), in which rastafarai to 17.25 g of α-tocopherol (template), 6,12 g of methacrylic acid and 76,32 g trimethylolpropane. The mixture under stirring (100 rpm) was heated to a temperature of 65°C, after which selected the sample for analysis by HPLC. ZAT is m in 5 ml of acetonitrile was dissolved 0,564 g of 2,2'-azobis(2-methylbutyronitrile) (initiator). The solution was slowly dosed out a syringe into the reactor. Through every hour of the reactor was selected sample of the reaction mixture by volume of 10 ml, which after filtration was analyzed by HPLC. The total reaction time was 5 hours. Upon completion of the polymerization, the polymer slurry was discharged from the reactor and filtered through a suction filter. The filter residue was washed with three portions of acetonitrile volume of 100 ml and was dried in vacuum at 50°C.

Example 2. Extraction of the active substance from polymer

A round bottom flask with a volume of 500 ml was given to conventional Soxhlet extractions, refrigerator, magnetic stirrer and laboratory temperature controller (Julabo LC 3 with two sensors PT 100) and placed in an oil bath. In to conventional Soxhlet extractions for 6-8 hours by 400 ml of methanol/glacial acetic acid with a volume ratio of 7:1 (extract 1) and during the next 6 hours by 400 ml of methanol (extract 2) was extracted with 8 g of polymer. Defined volume of extracts, selected a sample of each volume of 2 ml to determine the concentration of α-tocopherol by HPLC and the samples were stored in refrigerator at 4°C.

Example 3. Introduction cosmetic active substance in the polymer

1 g extracted in to conventional Soxhlet extractions and subjected to drying of the polymer were mixed with 10 ml of the solution is of fipronil concentration of 0.14 mol/l, which was prepared by dissolving 3 g of α-tocopherol in 50 ml of acetonitrile. After 3 hours, the liquid phase was separated from the polymer by centrifugation (15 minutes at 3800 rpm) and then desantirovaniya. The polymer was dried in vacuum at 50°C.

Example 4. Controlled release of cosmetic active substances of molecular imprinted polymers

The cell to ultrafiltrable model 8400 with ultra-thin filter connected with a water filled plastic container with a volume of 5 liters, is used as the collector. In the cell was injected dispersion of 100 mg of polymer in 100 ml of water, which within 15 minutes homogenized by stirring with a built-in cell magnetic stirrer. The extractant (water) was fed into the cell from the collector through the inlet line without excess pressure. Coming out of the bottom of the cell extract was received into the receiving vessel. In conclusion, defined volume, mass and time for individual fractions and each fraction was collected, the sample volume of 2 ml

During the experiment, collected several factions. Samples are passed through a filter of 0.45 ml) and kept in the refrigerator at 4°C for subsequent determination of the concentration of α-tocopherol by HPLC. Upon completion of the experiment the dispersion was unloaded from the vessel and Packed up.

Example 5. Controlled release of cosmetics on setoudeh substances of molecular imprinted polymers

100 mg of molecular imprinted polymer was placed in a conical flask of 250 ml was Then added 100 ml of extractant (water with a defined pH), the flask was closed, and the suspension is for 6 hours, stirred at room temperature. Every 30 minutes the flask was selected sample volume of 1 ml In conclusion, the product was pumped out on the filter and selected a sample of filtrate volume of 1 ml for analysis by HPLC. In this way during the experiment, we selected 13 samples (including the initial time t=0). The samples were passed through a filter of 0.45 ml), was placed in the injection flask and used for the determination of tocopherol by HPLC method.

Examples dermocosmetics drugs

Below are examples proposed in the invention dermocosmetics-containing preparations obtained according to example 1 molecular imprinted polymer with α-tocopherol as a template. Specified in these examples, molecular imprinted polymers with α-tocopherol as a template abbreviated MIP. Mole its imprinted polymer with α-tocopherol as a template in these examples, the equivalent in any other specified polymers, mole its imprinted active ingredient. For professionals it is obvious that in accordance with example 1 can be obtained and used in the following is the courthouse square and any other specified active ingredients.

Example 8. The use of MIP in cleansing lotion type "oil in water" for the face

Water spray 1%:

% Ingredient (INCI nomenclature)

And10,0Cetearyl ethylhexanoate
10,0Caprylic/capric triglyceride
1,5Cyclopentasiloxane, cyclohexasiloxane
2,0the polyethylene glycol-40 gidrirovannoe castor oil
In3,5the copolymer, Caprylic/capric triglyceride, sodium
acrylates
1,0tocopherylacetate
0,2bisabolol
dostat. Nr.(q.s.) preservative
dostat. Nr.(q.s.) perfume m the slo
D3,0Polyquaternium-44
0,5catrimani methosulfate
0,5cetearate-25
2,0panthenol, propylene glycol
4,0propylene glycol
0,1disodium ethylenediaminetetraacetic acid
1,0an aqueous solution (about 5% MIP)
60,7demineralized water.
Water spray 5%:
%Ingredient (INCI nomenclature)
A10,0Cetearyl ethylhexanoate
10,0Caprylic/capric triglyce the ID
1,5Cyclopentasiloxane, nikogossian
2,0the polyethylene glycol-40 gidrirovannoe castor oil
B3,5the copolymer, Caprylic/capric triglyceride, sodium
acrylates
C1,0tocopherylacetate
0,2bisabolol
q.s.preservative
q.s.perfume oil
D3,0Polyquaternium-44
0,5catrimani methosulfate
0,5cetearate-25
2,0 panthenol, propylene glycol
4,0propylene glycol
0,1disodium ethylenediaminetetraacetic acid
5,0an aqueous solution (about 5% MIP)
56,7demineralized water.

Preparation: dissolve the components of phase a; mixing phase with the phase A; the introduction of phase With the combination of phases a and b; the dissolution of the components of phase D, which is mixed with a combination of phases a, b and C and homogenize; additional stirring for 15 minutes.

Example 9. The use of MIP in the daily spray for body care

Water spray 1%:

% Ingredient (INCI nomenclature)

And3,0ethylhexylacrylate
2,0diethylaminoethylmethacrylate
1,0Polyquaternium-44
3,0propylene glycol
2,0panthenol, propylene glycol
1,0Cyclopentasiloxane, cyclohexasiloxane

10,0octyldodecanol
0,5polyvinylpyrrolidone
10,0Caprylic/capric triglyceride
3,0C12-alkylbenzoic
3,0glycerin
1,0tocopherylacetate
0,3bisabolol
1,0an aqueous solution (about 5% MIP)
59,2ethyl alcohol.
Water spray 5%:
%Ingredient (INCI nomenclature)
3,0ethylhexylacrylate
2,0diethylaminoethylmethacrylate
1,0Polyquaternium-44
3,0propylene glycol
2,0panthenol, propylene glycol
1,0Cyclopentasiloxane, cyclohexasiloxane
10,0octyldodecanol
0,5polyvinylpyrrolidone
10,0Caprylic/capric triglyceride
3,0C12-15A is giventhat
3,0glycerin
1,0tocopherylacetate
0,3bisabolol

5,0an aqueous solution (about 5% MIP)
55,2ethyl alcohol.

Preparation: using the components of phase a and dissolve until clear solution is formed.

Example 17. The use of MIP in the emulsion of the type water-in-oil" with bisabolol

Water spray 1%:
%Ingredient (INCI nomenclature)
A6,0the polyethylene glycol-7 gidrirovannoe castor oil
8,0Cetearyl ethylhexanoate
5,0isopropylmyristate
15,0mineral oil
0,3magnesium stearate
0,3the aluminum stearate
2,0copolymer of polyethylene glycol-45/dodecylphenol
In5,0glycerin
0,7magnesium sulfate
55,6demineralized water

tocopherylacetate.
1,0an aqueous solution (about 5% MIP)
0,5tocopherylacetate
0,6bisabolol.
Water spray 5%:
%Ingredient (INCI nomenclature)
And6,0the polyethylene glycol-7 gidrirovannoe castor oil
8,0Cetearyl ethylhexanoate
5,0isopropylmyristate
15,0mineral oil
0,3magnesium stearate
0,3the aluminum stearate
2,0copolymer of polyethylene glycol-45/dodecylphenol
In5,0glycerin
0,7magnesium sulfate
51,6demineralized water
5,0an aqueous solution (about 5% MIP)
0,5

Preparation: separate heating phases a and b to a temperature of about 85°C.; mixing phase with the phase a and homogenize; cooling to a temperature of about 40°C under stirring; add phase C and repeated short-term homogenization, cooling to room temperature under stirring.

Example 24. Style product in the form of foam

Water spray 1%:
%Ingredient (range INCl)
And2,00catrimani methosulfate
q.s.perfume oil
In72,32demineralized water
2,00copolymer of vinyl pyrrolidone/acrylate/laurenmarie
0,53AMP
1,00an aqueous solution (about 5% MIP)
0,20cetearate-25
0,50panthenol
0,05benzophenone-4
0,20amodimethicone, ceremony chloride, Trideceth-12
15,00ethanol
0,20hydroxyethylcellulose
D6,00propane/butane.

Water spray 5%:
%Ingredient (range INCl)
And2,00catrimani methosulfate
q.s.perfume oil
In68,32demineralized water
2,00copolymer of vinyl pyrrolidone/acrylate/lauryl methacrylate
0,53AMP
5,00an aqueous solution (about 5% MIP)
0,20cetearate-25
0,50panthenol
0,05benzophenone-4
0,20amodimethicone, ceremony chloride, Trideceth-12
15,00ethanol
0,20hydroxyethylcellulose
D6,00propane/butane.

Preparation: mix the components of phase a; sequential addition and dissolution of the components of phase B; the dissolution phase in the mixture of phases a and b, and establishing a pH in the range from 6 to 7; add phase D.

Example 36. LM is the cue makeup of type oil-in-water"

Water spray 1%:
%Ingredient (range INCl)
And2,0cetearate-6, stearyl alcohol
2,0cetearate-25
6,0literallayout
1,0cetyl alcohol
8,0mineral oil
7,0Cetearyl ethylhexanoate
0,2Dimethicone
In3,0propylene glycol
1,0panthenol
q.s.preservative
demineralized water
0,1bisabolol
1,0an aqueous solution (about 5% MIP)
q.s.perfume oil
Dthe 5.7titanium dioxide (C.I. 77891)
1,1iron oxide.

Water spray 5%:
%Ingredient (range INCl)
And2,0cetearate-6, stearic alcohol
2,0cetearate-25
6,0literallayout
1,0cetyl alcohol
8,0 mineral oil
7,0Cetearyl ethylhexanoate
0,2Dimethicone
In3,0propylene glycol
1,0panthenol
q.s.preservative
57,9demineralized water
0,1bisabolol
5,0an aqueous solution (about 5% MIP)
q.s.perfume oil
Dthe 5.7titanium dioxide (C.I. 77891)
1,1iron oxide.

Preparation: phase a and b separately heated to a temperature of about 80°C.; the phase In the mixed phase a and homogenize; the mixture is ri stirring, cooled to a temperature of about 40°C; add phase C and D and perform a thorough re homogenization; composition with stirring, cooled to room temperature.

Example 37

Below are examples proposed in the invention dermocosmetics-containing preparations obtained according to example 1 molecular imprinted polymer with α-tocopherol as a template. Specified in these examples, molecular imprinted polymers with α-tocopherol as a template abbreviated MIP. Molecular imprinted polymer with α-tocopherol as a template in these examples is equivalent to any other polymers, molecular imprinted specified active ingredient. For professionals it is obvious that in accordance with example 1 can be obtained and used in the following preparations and any other specified active ingredients.

The following molecular imprinted active ingredient, the polymer used in the form of a solid product. Quantitative data are given in mass units.

Transparent shampoo

Ingredients (INCI)12345
Sodium Laureth sulfate 13,0015,0010,5012,5010,00
Cocamidopropylbetaine7,507,005,005,5010,00
The polyethylene glycol-7 literallayout2,002,503,505,002,30
Perfume oil0,100,100,100,100,10
MIP1,05,00,10,510,0
D-panthenol USP1,001,501,801,701,40
Preservative0,100,100,100,100,10
Citric acid 0,100,100,100,100,10
Luviquat®Ultra Care1,501,001,501,201,10
Sodium chloride1,501,401,401,301,50
Demineralized water100100100100100

Shampoo

Ingredients (INCI)12345
Sodium Laureth sulfate35,0040,0030,0045,0027,00
Disillusioned5,005,504,90 3,507,00
Cocamidopropylbetaine10,005,0012,507,5015,00
Perfume oil0,100,100,100,100,10
MIP1,05,00,10,510,0
D-panthenol USP0,501,000,801,500,50
Preservative0,100,100,100,100,10
Citric acid0,100,100,100,100,10
Laureth-30,502,000,500,50 2,00
Sodium chloride1,501,501,501,501,50
Demineralized water100100100100100

Clear conditioning shampoo

Ingredients (INCI)12345
®Disodium cocoamphodiacetate10,0015,0020,0012,0017,00
®Disillusioned5,006,007,008,004,00
®Cocamidopropylbetaine15,0012,0010,0018,000,00
Luviquat®FC 5500,300,200,200,200,30
Perfume oil0,100,100,100,100,10
MIP20,05,01,00,510,0
Cremophor®PS 205,001,001,007,005,00
Preservative0,100,100,100,100,10
®Laureth-32,001,000,502,002,00
Citric acid0,200,200,200,200,2
The polyethylene glycol-12 distearate3,002,002,003,002,50
Demineralized water100100100100100

Foaming of the emulsion of the type oil-in-water"

Emulsion 1Emulsion 2
% mass%% mass% vol.
Stearic acid5,001,00
Cetyl alcohol5,50
Cetearyl alcohol2,00
The peg-40 stearate8,50
The peg-20 stearate1,00
Caprylic/capric triglyceride4,002,00
With 12-15 alkylbenzoic10,0015,00
Cyclomethicone4,00
Dimethicone0,50
MIP5,010,0
Ethylhexylphthalate5,00
Myristoleate2,00
Ceresin1,50
Glycerin3,00
Hydroxypropyl starch phosphate1,003,50
Butylacetyl0,02
Dinitroanthraquinone acid0,500,10
Perfume oil, preservativeqs.qs
DyeqsqsThe potassium hydroxideqsqs
Demineralized water100100
pH of 6.5 to 7.5pH from 5.0 to 6.0
Emulsion 170
Emulsion 235
Nitrogen30
Propane/butane65

Conditioning shampoo with pearl glitter

12 3
Polyquaternium-100,500,500,40
Sodium Laureth sulfate9,008,508,90
Cocamidopropylbetaine2,502,603,00
Uvmul®MS 401,500,501,00
MIP1,05,00,5
The solution to impart a pearlescent Shine2,002,50
Disodium ethylenediaminetetraacetic acid0,100,150,05
Preservative, perfume oil, thickenerqsqs.qs.
Demineralized water100100100
pH 6.0

Clear conditioning shampoo

123
Polyquaternium-100,500,500,50
Sodium Laureth sulfate9,008,509,50
MIP5,00,13,0
Uvinul M®401,001,500,50
Preservative, perfume oil, thickenerq.s.q.s.q.s.
Demineralized water100100100
pH 6.0

Clear conditioning shampoo with surround effect is m

123
Sodium Laureth sulfate10,0010,5011,00
Uvinul®MC 802,001,502,30
MIP10,00,10,5
Cocamidopropylbetaine2,502,602,20
Disodium ethylenediaminetetraacetic acid0,010,100,01
Preservative, perfume oil, thickenerqsqsqs.
Demineralized water100100100
pH 6.0

Cream-gel

1234
Cross-linked copolymer acrylates/C 10-30 alkylacrylate0,400,350,400,35
Carbomer0,200,220,200,22
Xanthan gum0,100,130,100,13
Cetearyl alcohol3,002,503,002,50
With 12-15 alkylbenzoic4,004,504,004,50
Caprylic/capric triglyceride 3,003,503,003,50
Uvinul®A Plus™2,001,500,751,00
UvaSorb®k2A (ethylhexyl bis-isopentyl-benzoxazolinone)3,00
Uvinul®MC 803,001,00
Bis-ethylhexyloxymethyl-triazine1,502,00
Butylperoxybenzoate2,00
Disodium phenyldiazonium tetrasulfonic 2,500,502,00
Uvinul®T 1504,003,004,00
Octocrylene4,00
Diethylhexylphthalate1,002,00
Phenylbenzimidazol acid0,503,00
Methylene bis-benzothiazolesulfenamide-butylphenol2,000,501,50
Ethylhexenal ilat 3,00
Drometrizole trisiloxane0,50
Terephthalic dicamphor of surfacesof1,501,00
Diethylhexyl 2,6-naphtalate3,504,007,009,00
Titanium dioxide (ultrapure)1,003,00
Zinc oxide (ultrapure)0,25
MIP0,10,51,00,02
Cyclomethicone5,005,505,005,50
Dimethicone1,000,601,000,60
Glycerin1,001,201,001,20
Sodium hydroxideqsqsqsqs
Preservative0,300,230,300,23
Perfume oil 0,200,20
Demineralized water100100100100
pH 6.0

The formulation of sunscreen type oil-in-water"

1234567
Literallayout SE0,501,003,001,50
Glyceryltrinitrate2,001,002,00 4,00
Stearic acid3,002,00
The peg-40 stearate0,502,00
Cetilistat1,00
Sodium clearesult0,75
Stearyl alcohol3,002,000,60
Terephthalate dicamphor acid
Cetyl alcohol2,501,101,500,602,00
MIP10,00,53,05,00,10,027,5
Uvinul®A Plus™2,001,500,751,002,104,505,00
UvaSorb®k2A (ethylhexyl bis-isobutyleneisoprene-melamine)
Ethylhexylacrylate Uvinul®MC 805,006,00 8,00
Bis-ethylhexyloxyphenol-methoxyphenylalanine1,502,002,502,50
Butylperoxybenzoate2,002,001,50
Disodium phenyldiazonium tetrasulfonic2,500,502,000,30
Ethylhexylacrylate Uvinul®T 1504,003,004,002,00
Octocrylene4,00,50
Diethylhexyl butanetriol1,002,001,001,00
Phenylbenzimidazol acid0,503,00
Methylene bis-benzotriazolyl-tetramethylbutylphenol2,000,501,502,50
Ethylhexyl salicylate3,005,00
Drometrizole trisiloxane0,501,00
1,501,001,000,50
Diethylhexyl 2,6-naphtalate3,507,006,009,00
Titanium dioxide (ultrapure)1,003,003,501,50
Zinc oxide (ultrapure)0,252,00
C12-15 alkylbenzoic0,254,007,00
Dicaprylyl ether 3,502,00
Butyleneglycol dicaprylate/dicaprate5,006,00
Cocoglyceride6,002,00
Dimethicone0,501,002,00
Cyclomethicone2,000,500,50
Butyrospermum Parkn (Shea butter)2,00
Copolymer of vinyl pyrrolidone/hexadecan0,200,501,00
Glycerin3,007,507,505,002,50
Xanthan gum0,150,050,30
Sodium carbomer0,200,150,25
Vitamin E acetate0,600,230,701,00
Biochina resin-13,0010,00
Glycine soybean oil (soy bean)0,501,501,00
Ethylhexylglycerin0,30
DMDMH as the0,600,400,20
Iodopropynyl of BUTYLCARBAMATE0,180,20
Methylparaben 0,150,250,50
Phenoxyethanol1,000,400,400,500,40
Trinacria ethylenediaminetetraacetic acid0,020,05
Tetranitro iminodisuccinate0,251,00
Ethanol2,001,503,001,205,00
Perfume oil0,100,25 0,300,400,20
Demineralized water100100100100100100100

Hydro dispersion

12345
Cetearate-201,000,50
Cetyl alcohol1,00
Sodium carbomer0,200,30
Cross-linked copolymer acrylates/C 10-30 alkylacrylate0,50 0,400,100,50
Xanthan gum0,300,15
MIP5,00,53,00,110,0
UvinuFAPIus™2,001,500,751,002,10

td align="left">
UvaSorb®k2A (ethylhexyl bis-ISO-pentylbenzenesulfonyl)3,50
Ethylhexyl methoxycinnamate Uvinul®MS5,00
Bis-ethylhexyloxyphenol-phenyltriazine1,50 2,002,50
Butylperoxybenzoate2,002,00
Disodium phenyldiazonium tetrasulfonic2,500,502,00
Ethylhexylacrylate Uvinul®T 1504,003,004,00
Octocrylene4,00
Diethylhexylphthalate1,002,001,00
Phenylbenzimidazol acid0,503,00
Methylene bis-benzotriazolyl the tra-methylbutanol 2,000,501,502,50
Ethylhexylglycerin3,00
Drometrizole trisiloxane0,50
Terephthalate dicamphor acid1,501,001,00
Diethylhexyl 2,6-naphtalate7,009,00
Titanium dioxide (ultrapure)1,003,003,50
Zinc oxide (ultrapure)0,25
C12-15 alkylbenzoic2,002,50
Dicaprylyl ether4,00
Butyleneglycol/dicaprate4,002,006,00
Disabilitant2,006,00
Dimethicone0,501,00
Fenitrothion2,000,50
Butyrospermum Parkii (Shea butter)2,00 5,00
Copolymer of vinyl pyrrolidone/hexa-mission0,500,501,00
Tricontanyl polyvinylpyrrolidone0,501,00
Ethylhexylglycerin1,000,80
Glycerin3,007,507,508,50

Glycine soybean oil (soy bean)1,501,00
Vitamin E acetate0,500,251,00
Gluco is erroten 0,600,25
Biochina resin-12,500,502,00
DMDMH as the0,600,450,25
Iodopropynyl of BUTYLCARBAMATE0,20
Methylparaben0,500,250,15
Phenoxyethanol0,500,401,00
Trinacria ethylenediaminetetraacetic acid0,010,050,10
Ethanol3,002,001,507,00
Perfume oil0,200,050,40
Demineralized water100100100100100

Emulsion from sunburn type "water in oil"

12345
Cetyl Dimethicone2,504,00
Polyglyceryl-dipolyhydroxystearate5,004,50
The polyethylene glycol-30 dipolyhydroxystearate the t 5,00
MIP5,01,010,00,50,1
Uvinul®A Plus™2,001,500,751,002,10
UvaSorb®k2A (ethylhexyl bis-ISO-pentylbenzenesulfonyl)2,00
Ethylhexylacrylate Uvinul®MS5,00
Bis-ethylhexyloxyphenol-phenyltriazine1,502,002,50
Butylperoxybenzoate 2,002,00
Disodium phenyldiazonium tetrasulfonic2,500,502,00
Ethylhexylacrylate Uvinul®T 1504,003,004,00
Octocrylene4,00
Diethylhexylphthalate1,002,001,00
Phenylbenzimidazol acid0,503,00
Methylene bisbenzimidazole tetramethylbutylphenol2,000,501,502,50
Ethylhexylglycerin3,00
Drometrizole trisiloxane0,50
Terephthalate dicamphor acid1,501,001,00
Diethylhexyl 2,6-naphtalate7,004,00
Titanium dioxide (ultrapure)1,003,003,50
Zinc oxide (ultrapure)0,25
Mineral oil12,0010,00 8,00
C12-15 alkylbenzoic9,00
Dicaprylyl ether10,007,00
Butyleneglycol/dicaprate2,008,004,00
Disabilitant5,006,00
Dimethicone4,001,005,00
Cyclomethicone2,0025,002,00
Butyrospermum Parkii (Shea butter) 3,00
Vaseline oil4,50
Copolymer of vinyl pyrrolidone/hexadecan0,500,501,00
Ethylhexylglycerin0,301,000,50
Glycerin3,007,507,508,50
Glycine soybean oil (soy bean)1,001,501,00
Magnesium sulfate (MgSO4)1,000,500,50
Magnesium chloride (MgCl2) 1,000,70
Vitamin E acetate0,500,251,00
Ascorbyl palmitate0,502,00
Biochina resin-13,501,00
DMDMH as the0,600,400,20
Methylparaben0,500,250,15
Phenoxyethanol0,500,401,00
Trinacria ethylenediaminetetra Sosna acid 0,120,050,30
Ethanol3,001,505,00
Perfume oil0,200,400,35
Demineralized water100100100100100

Cosmetic pencils

1234
Caprylic/katrinaville12,0010,006,00
Octyldodecanol7,0014,008,003,00
Butyleneglycol/dicaprate12,00
Pentaerythrityl tetraisostearate10,006,008,007,00
Polyglyceryl-3 diisostearate2,50
Bottiglieri polyacyladipate-29,008,0010,008,00
Cetearyl alcohol8,0011,009,007,00
Myristoleate3,503,004,003,00
Beeswax5,005,006,006,00
Copernicia Cenfera (Carnauba wax)1,502,002,00 1,50
White wax0,500,500,500,40
C16-40 alterstart1,501,501,50
MIP0,53,01,05,0
Uvinul®A Plus™2,001,500,759,00
UvaSorb®k2A (ethylhexyl bis-isopen-tilintarkastustoiminnan)2,004,00
Ethylhexyl methoxycinnamate Uvinul®MS3,00
Bis-ethylhexyloxyphenol-phenyltriazine1,502,00
Butylperoxybenzoate 2,00
Disodium phenyldiazonium tetrasulfonic2,500,502,00
Ethylhexyl treason Uvinul®T 1504,003,004,00
Octocrylene4,00
Diethylhexylphthalate1,002,00
Phenylbenzimidazol acid0,503,00

Methylene bis-benzotriazolyl-methylbutanol2,000,501,50
Ethylhexyl salicylate 3,00
Drometrizole trisiloxane0,50
Terephthalate dicamphor acid1,501,00
Diethylhexyl 2,6-naphtalate7,00
Titanium dioxide (ultrapure)1,003,00
Zinc oxide (ultrapure)0,25
Vitamin E acetate0,501,00
Ascorbyl palmitate0,050,05
Buxux Chinensis (oil str) 2,001,001,00
Perfume oil, butylacetyl0,100,250,35
Ricinus Communis (castor oil)100100100100

PIT-EMULSION

0,50
12345678
Glyceril the monostearate SE0,502,003,005,000,504,00
Glyceryl isostearate3,504,002,00
Isoceteth-200,502,00
Cetearate-125,001,003,505,00
Cetearate-205,001,003,50
The polyethylene glycol-100 stearate2,802,303,30
Cetyl alcohol5,201,201,001,300,30
Cetylpalmitate2,501,201,500,501,50
Cetyl Dimethicone copolyol0,501,00
Polyglyceryl-2-diolein0,750,30
MIP0,15,00,010,53,00,2510,03,0
Uvinul®A Plus™2,001,500,751,00210 4,505,002,10
UvaSorb®k2A (ethylhexyl bis-isopentylbarbital-fenilalanina)4,001,50
Ethylhexyl methoxycinnamate Uvinul®MC 805,006,008,005,00
Bis-ethylhexyloxyphenol-methoxyphenylalanine1,502,002,502,502,50
Butylperoxybenzoate2,002,001,502,00
Disodium phenyldiazonium tetrasulfonic2,500,502,000,30
Ethylhexylacrylate Uvinul®T 1504,003,004,002,00
Octocrylene4,007,50
Diethylhexyl butanetriol1,002,001,001,001,00
Phenylbenzimidazol acid0,503,00
Methylene bis-benzotriazolyl-tetramethylbutylphenol2,000,501,502,502,50
Ethylhexylglycerin3,005,00
Drometrizole trisiloxane0,501,00
Terephtalate dicamphor acid1,501,001,000,501,00
Diethylhexyl 2,6-naphtalate 7,0010,007,508,00
Titanium dioxide (ultrapure)1,003,003,501,503,50
Zinc oxide (ultrapure)0,252,00
C12-15 alkylbenzoic3,506,350,10
Cocoglyceride3,003,001,00/td>
Dicaprylyl ether4,50
Dicaprylyl carbonate4,303,007,00
Dibutyltin0,500,30
Fenitrothion2,003,502,00
Cyclomethicone3,00
C1-5 Alkylglucoside0,502,00
Hydrogenated cocoglyceride3,004,00
Beginanimation1,502,00
Copolymer of vinyl pyrrolidone/hexadecan1,001,20
Glycerin4,006,005,00 8,0010,00
Vitamin E acetate0,200,300,400,30
Butyrospermum Parkn (Shea butter)2,003,602,00
Iodopropionic0,120,20
Biochina resin-10,10
DMDMH as the0,10 0,120,13
Methylparaben0,500,300,35
Phenoxyethanol0,500,401,00
Ethylhexylglycerin0,301,000,35
Ethanol2,002,005,00
Trinitry the Ethylenediamine-Ter the acetic acid 0,400,150,20
Perfume oil0,200,200,240,160,100,10
Demineralized water100100100100100100100100

Cream-gel

1234
Cross-linked copolymer acrylates/C10-30 alkylacrylate0,400,350,400,35
Carbomer0,200,22 0,200,22
Luvigel®EAT1,502,502,803,50
Xanthan gum0,100,130,100,13
Cetearyl alcohol3,002,503,002,50
C12-15 alkylbenzoic4,004,504,004,50
Caprylic/capric triglyceride3,003,503,003,50
Titanium dioxide (ultrapure)1,001,50
Zinc oxide (ultrapure)2,000,25
MIP0,510,0 3,05,0
Dihydroxyacetone3,005,00
Cyclomethicone5,005,505,005,50
Dimethicone1,000,601,000,60
Glycerin1,001,201,001,20
Sodium hydroxideqsqsqsqs
Preservative0,300,230,300,23
Perfume oil0,200,20
Demineralized water100100100 100
pH 6.0

Recipe type oil-in-water to simulate the sun

1234567
Glyceril the monostearate SE0,501,003,001,50
Glyceryl stearate citrate2,001,002,004,00
Stearic acid3,002,00
The peg-40 stearate 0,502,00
Cetilistat1,00
Clearesult0,75
Stearyl alcohol3,002,000,60
Cetyl alcohol2,501,101,500,602,00
MIP0,10,50,0255,010,01,0
Dihydroxyacetone3,005,004
Titanium dioxide (ultrapure)1,001,501,50
Zinc oxide (ultrapure)0,252,00
C12-15 alkylbenzoic0,254,007,00
Dicaprylyl ether3,502,00
Butyleneglycol dicapri-lat/dicaprate5,006,00
Cocoglyceride6,002,00
Dimethicone0,501,002,00
Zipomatic2,000,500,50
Butyrospermum Parkn (Shea butter)2,00
Copolymer of vinyl pyrrolidone/hexadecan 0,200,501,00
Glycerin3,007,507,505,002,50
Xanthan gum0,150,050,30
Sodium carbomer0,200,150,25
Vitamin E acetate0,600,230,701,00
Biochina resin-13,0010,00
Glycine soybean oil (soy bean)0,501,501,00
Ethylhexylglycerin0,30
DMDMH as the0,600,400,20
Iodopropynyl of BUTYLCARBAMATE0,180,20
Methylparaben0,150,250,50
Phenoxyethanol1,000,400,400,500,40
Trinitry the Ethylenediamine-tetraoxane acid0,020,05
Tetranitro iminodisuccinate0,251,00
Ethanol2,001,503,001,205,00
Perfume oil0,100,250,300,400,20
Demineralized the water output 100100100100100100100

The makeup of type oil-in-water"

1234567
Glyceril the monostearate SE0,501,003,001,50
Glyceryl stearate citrate2,001,002,004,00
Stearic acid3,002,00
The polyethylene is glycol 40 stearate 0,502,00
Cetilistat1,00
Clearesult0,75
Stearyl alcohol3,002,000,60
Cetyl alcohol2,501,101,500,602,00
MIP3,05,02,0 0,51,05,010,0
Titanium dioxide10,0012,009,008,5011,009,5010,00
Iron oxide2,004,003,005,003,406,004,40
Zinc oxide4,002,003,00
C12-15 alkylbenzoic0,254,007,00
Dicaprylyl ether3,502,00
Butyleneglycol dicaprylate/dicaprate5,006,00
Cocoglyceride6,002,00
Dimethicone0,501,002,00
Cyclomethicone2,000,500,50
Butyrospermum Parkn (Shea butter)2,00
Copolymer of vinyl pyrrolidone/hexadecan 0,200,501,00
Glycerin3,007,507,505,002,50
Xanthan gum0,150,050,30
Sodium carbomer0,200,150,25
Vitamin E acetate0,600,230,701,00
Glycine soybean oil (soy bean) 0,501,501,00
Ethylhexylglycerin0,30
DMDMH as the0,600,400,20
Iodopropynyl carbamate0,180,20
Methylparaben0,150,250,50
Phenoxyethanol1,000,400,400,50 0,40
Trinitry the Ethylenediamine-tetraoxane acid0,020,05
Tetranitro iminodisuccinate0,251,00
Ethanol2,001,503,001,205,00
Perfume oil0,100,250,300,400,20
Demineralized water100100100100100100100

Hydra is the dispersion to simulate the sun

12345
Cetearate-201,000,50
Cetyl alcohol1,00
Luvigel®EAT2,002,502,00
Cross-linked copolymer acrylates/C 10-30 alkylacrylate0,500,400,100,50
Xanthan gum0,300,15
MIP3,01,00,5 0,15,0
Dihydroxyacetone3,005,00
Uvinul®A Plus™2,001,500,751,002,10
Titanium dioxide (ultrapure)1,001,001,00
Zinc oxide (ultrapure)1,900,25
C12-15 alkylbenzoic2,002,50
Dicaprylyl ether4,00
Butyleneglycol/dicaprate4,00 2,006,00
Disabilitant2,006,00
Dimethicone0,501,00
Fenitrothion2,000,50
Butyrospermum Parkn (Shea butter)2,005,00
Copolymer of vinyl pyrrolidone/hexa-mission0,500,501,00
Tricontanyl polyvinylpyrrolidone0,501,00
Ethylhexylglycerin1,000,80
Glycerin3,007,507,508,50
Glycine soybean oil (soy bean)1,501,00
Vitamin E acetate0,500,251,00
Glucosylrutin0,600,25
DMDMH as the0,600,450,25
Iodopropynyl0,20
Methylparaben is n 0,500,250,15
Phenoxyethanol0,500,401,00
Trinacria ethylenediaminetetraacetic acid0,010,050,10
Ethanol3,002,001,507,00
Perfume oil0,200,050,40
Demineralized water100100100100100

Hydro dispersion for skin care after sun

1 2345
Cetearate-201,000,50
Cetyl alcohol1,00
Luvigel®EAT2,002,502,00
Cross-linked copolymer acrylates/C10-30 alkylacrylate0,500,300,400,100,50
Xanthan gum0,300,15
MIP0,15,00,53,01,0
C12-15 alkylbenzoic2,00 2,50
Dicaprylyl ether4,00
Butyleneglycol/dicaprate4,002,006,00
Disabilitant2,006,00
Dimethicone0,501,00
Fenitrothion2,000,50
Tricontanyl polyvinylpyrrolidone0,501,00
Ethylhexylglycerin 1,000,80
Glycerin3,007,507,508,50
Glycine soybean oil (soy bean)1,501,00
Vitamin E acetate0,500,251,00
Glucosylrutin0,600,25
Trinacria ethylenediaminetetraacetic acid0,010,050,10
Ethanol15,0010,008,0012,009,00
Perfume oil0,200,050,40
Demineralized water100100100100100

Emulsion type water in oil"

12345
Cetyl Dimethicone2,504,00
Polyglyceryl-2 typologically-stearate5,004,50
The glycol-tipologizatsiej 5,00
MIP5,010,00,10,51,0
Uvinul®A Plus™2,001,500,751,002,10
Titanium dioxide (ultrapure)1,003,003,50
Zinc oxide (ultrapure)0,900,25
Mineral oil12,0010,008,00
C12-15 alkylbenzoic 9,00
Dicaprylyl ether10,007,00
Butyleneglycol/dicaprate2,008,004,00
Disabilitant5,006,00
Dimethicone4,001,005,00
Cyclomethicone2,0025,00 2,00
Butyrospermum Parkn (Shea butter)3,00
Vaseline oil4,50
Copolymer of vinyl pyrrolidone/hexadecan0,500,501,00
Ethylhexylglycerin0,301,000,50
Glycerin3,007,507,508,50
Glycine soybean oil (soy bean)1,00 1,501,00
Magnesium sulfate1,000,500,50
Magnesium chloride1,000,70
Vitamin E acetate0,500,251,00
Ascorbyl palmitate0,502,00
Biochina resin-13,507,00
DMDMH as theis the 0,600,400,20
Methylparaben0,500,250,15
Phenoxyethanol0,500,401,00
Trinitrotoluenes acid0,120,050,30
Ethanol3,001,505,00
Perfume oil0,200,400,35
Demineralized water100100100100100

Stable solid emulsion (emulsion Pickering)

12345
Mineral oil16,0016,00
Octyldodecanol9,009,005,00
Caprylic/katrinaville9,009,006,00
C12-15 alkylbenzoic5,00Butyleneglycol/dicaprate8,00
Dicaprylyl ether9,004,00
Disabilitant9,00
Hydroxystanozolol hydroxystearate2,002,002,202,501,50
Disteardimonium hectorite1,000,750,500,25
Microcrystalline wax + vaseline oil0,355,00
The hypromellose0,100,05
Dimethicone3,00
MIP1,00,50,13,05,0
Titanium dioxide + aluminium oxide + simethicone + liquid3,00
Titanium dioxide+trimethoxysilyl-silane2,004,002,004,00
Silicon dioxide, dimethylsilane2,506,002,50
The boron nitride1,00
Polymer starch/metaphosphate sodium2,00
Starch from tapioca0,50
Sodium chloride5,007,008,503,004,50
Glycerin1,00
Trinacria ethylenediaminetetraacetic acid1,001,001,001,001,00
Vitamin E acetate5,0010,003,006,0010,00
Ascorbyl palmitate1,001,001,00
Methylparaben0,600,20
Propylparaben0,20
Phenoxyethanol0,20
Gescheiden diisocyanate0,400,500,40
Diazolidinyl urea0,08
Ethanol0,230,20
Perfume oil5,003,00 4,00
Demineralized water0,200,300,10
100100100100100

Oil-gel

1234
Caprylic/capric triglyceride12,0010,006,00
Octyldodecanol7,0014,008,003,00
Butyleneglycol/dicaprate12,00
Pentaerythritoltetranitrate10,006,008,00 7,00
Polyglyceryl-3 diisostearate2,50
Bis-deglycerolized-29,008,0010,008,00
Myristoleate3,503,004,003,00
Quatermum-18 bentonite5,005,006,006,00
Propylene carbonate15,0020,0018,0019,50
MIP1,00,53,05,0
Vitamin E acetate0,501,00
Ascorbyl palmitate0,050,05the
Buxus Chinensis oil str)2,001,001,00
Perfume oil, butylacetyl0,100,250,35
Ricinus Communis (castor oil)100100100100

Example 38

The following formulas apply to cosmetic products for sun protection, contains a combination of at least one inorganic pigment, preferably zinc oxide and/or titanium dioxide, organic UV-a and UV-b filter and obtained in accordance with example 1 molecular imprinted polymer with α-tocopherol as a template. Specified in these examples, molecular imprinted polymers with α-tocopherol as a template abbreviated MIP. Molecular imprinted polymer with α-tocopherol as a template in these examples is equivalent to any other polymers, molecular imprinted specified active ingredient. For professionals it is obvious that in accordance with example 1 can be obtained and used is the following drugs and any other specified active ingredients.

The template in molecular imprinted polymers preferably is an organic UV filter that are released on the skin in accordance with the above mechanism.

The preparation of the following compositions by prominent specialists conventional methods.

The content of molecular imprinted the active ingredient of the polymer is given in terms of 100%. Proposed in the invention of molecular imprinted active ingredient, the polymer can be used in pure form or in aqueous solution. In the case of aqueous solution, the water content must be agreed with its contents in the appropriate composition.

And 7,50 Uvinul MC 80Ethylhexylamine
2,00 UvinulM40Benzophenone-3
0,80 RyloPGHPolyglyceryl dimer soyat
1,00 Span 60Servicestart
0.50 Vitamin E-acetateTocopherylacetate
3,00 Dracorin 100SELiterallayout, polyethylene glycol-100 stearate
1,00 CremophorC0410 The polyethylene glycol-40 gidrirovannoe castor oil
In 3,00 T-Lite SFTitanium dioxide, aluminum hydroxide, the copolymer of the Dimethicone/Medicon
1,00 CetiolSB45Butyrospermum Parkii (Shea butter)
6,50 FinsolvTNC12-15 alkylbenzoic
With 5.00 ButyleneglycolButyleneglycol
0,30 KeltrolXanthan gum
0,10 Edeta BDDisodium ethylenediaminetetraacetic acid
0.10 AllantoinAllantoin
66,20 Demineralized waterDemineralized water
D 1,00 Sepigel 305Polyacrylamide, C13-14 isoparaffin, Laureth-7
1% MIP
q.s.Preservative
And 7,50 Uvinul MC 80Ethylhexylamine
2,00 Uvinul M 40Benzophenone-3
0,80 RyloPGHPolyglyceryl on the measures soyat
1,00 Span 60Servicestart
0.50 Vitamin E-acetateTocopherylacetate
3,00 Dracorin 100SELiterallayout, polyethylene glycol-100 stearate
1,00 CremophorC0410The polyethylene glycol-40 gidrirovannoe castor oil
In 3,00 Z-COTE MAXZinc oxide (and) diphenyl capeletto
1,00 CetiolSB45Butyrospermum Parkii (Shea butter)
6,50 FinsolvTNC12-15 alkylbenzoic
With 5.00 ButyleneglycolButyleneglycol
0,30 KeltrolXanthan gum
0,10 EdetaBDDisodium ethylenediaminetetraacetic acid
0.10 AllantoinAllantoin
66,20 Demineralized waterDemineralized water
D 2,00 Simulgel NSThe copolymer of hydroxyethylacrylate/sodium acryloyldimethyltaurate, squalane, polisar is at 60
1% MIP
q.s.Preservative
And 7,50 Uvinul MC80Ethylhexylamine
2,00 Uvinul A PlusDiethylaminoethanol-hexylbenzoate
0,80 Rylo PG HPolyglyceryl dimer soyat
1,00 Span 60Servicestart
0.50 Vitamin E-acetateTocopherylacetate
3,00 Dracorin 100 SELiterallayout, polyethylene glycol-100 stearate
1,00 Cremophor CO 410The polyethylene glycol-40 selective and castor oil
In 3,00 Z-COTE MAXZinc oxide (and) diphenylamin-Medicon
1,00 Cetiol SB 45Butyrospermum Parkii (Shea butter)
6,50 Finsolv TNWith 12-15 alkylbenzoic
With 5.00 ButyleneglycolButyleneglycol
0,30 KeltrolXanthan gum
010 Edeta BD Disodium ethylenediaminetetraacetic acid
0.10 AllantoinAllantoin
66,20 Demineralized waterDemineralized water
D 2,00 Simulgel NSThe copolymer of hydroxyethylacrylate/sodium acryloyldimethyltaurate, squalane, Polysorbate 60
1% MIP
q.s.Preservative
And 1,00 Abil Care 85Bis-peg/polypropylenglycol-16/16 polyethylene glycol/polypropylenglycol/timation, Caprylic/capric triglyceride
3,00 Cremophor CO 40The polyethylene glycol-40 gidrirovannoe castor oil
0,30 Cremophor WO 7The polyethylene glycol-7 gidrirovannoe castor oil
2,00 Parsol 1789Butylperoxybenzoate
2,00 Mexoryl XLDrometrizole trisiloxane
10,00 Witconol APMPolypropylenglycol-3 ministerului ether
1,0 Uvinul T 150 Ethylhexylacrylate
1,00 Dow Corning 345 FluidCyclopentasiloxane, cyclohexa-siloxane
5,00 UvinulN539TOctocrylene
In 3,00 Z-COTE MAXZinc oxide (and) diphenylamin-Medicon
With 5,00 1,2-Propylene glycolPropylene glycol
1,00 MexorylSXTerephthalate dicamphor acid
0,20 KeltrolXanthan gum
0,06 EdetaBDDisodium ethylenediaminetetraacetic acid
0,04 TEATriethanolamine
0,30 Carbopol Ultrez 10PCarbomer
63,50 Demineralized waterDemineralized water
1% MIP
D q.s. Perfume oil
0,50 GlydantDMDMH as the
And 5.5 Uvinul MC 80Ethylhexylacrylate
2,00 Uvinul A PlusDiethylaminoethanol-hexylbenzoate
3,00 Uvinul N 539 TOctocrylene
3,00 Emulgade PL 68/50Cetearyl glucoside, Cetearyl alcohol
2,00 Dracorin 100 SELiterallayout, polietileno-Col-100 stearate
1,00 FitodermSqualane
0,50 Cremophor WO 7The polyethylene glycol-7 gidrirovannoe castor oil
0,50 Cremophor PS 20Polysorbate 20
2,00 Dry Flo PureAluminum starch octenylsuccinate
In 5,00 T-Lite SF-STitanium dioxide, silicon dioxide hydrate, aluminum hydroxide, the copolymer of Medicon/Dimethicone
From 4.00 1,2-Propylene glycol CarePropylene glycol
0,20 KeltrolXanthan gum
2,00 Simulgel NSThe copolymer of hydroxyethylacrylate/sodium acryloyldimethyltaurate, squalane, Polysorbate 60
to 66.30 Demineralized in the Yes Demineralized water
q.s. Preservative
0.50 Vitamin E-acetateTocopherylacetate
0,5% MIP
1,00 RetiSTARCaprylic/capric triglyceride, sodium ascorbate, tocopherol,retinol
5,00 Z-COTE MAXZinc oxide (and) diphenylethylamine
2,00 Parsol 1789Butylperoxybenzoate
1,00 Uvinul T 150Ethylhexylacrylate
5,00 Uvinul MC 80Ethylhexylacrylate
2,00 Uvinul T539 NOctocrylene
0,50 Abil 350Dimethicone
2,75 Carnicowachs LT 20Carnauba wax (Copernica Cerifera)wax
3,70 Candelillawachs LT LJ 281Kandellilsky wax (Euphorbia Cerifera)
1,80 beeswax 3050 PHBeeswax
320 TeCero-Wachs 30445 Microcrystalline wax
3,20 TeCero-Wachs 1030Microcrystalline wax
1,34 CutinaCPCetylpalmitate
6,40 VaselineVaseline oil
7,30 Softisan 100Hydrogenated cocoglyceride
10,00 Luvitol EHOCetearyl ethylhexanoate
0,17 Bisabolol naturalBisabolol
1,84 Vitamin E-acetateTocopherylacetate
0,42 0,1-alpha-tocopherolTocopherol
1% MIP
40,38 Castor oilCastor oil (Ricinus Communis)
5,00 T-Lite SFTitanium dioxide, aluminum hydroxide, the copolymer of the Dimethicone/Medicon
2,00 Parsol 1789Butylperoxybenzoate
1,00 UvinulT150Ethylhexylacrylate
3,00 UvinulMC80
2,00 UvmulN539TOctocrylene
0,50 Abil 350Dimethicone
2,75 Carnicowachs LT 20Carnauba wax (Coregui Cerifera)wax
3,70 Candelillawachs LT LJ 281Candelaresi wax (Euphorbia Cerifera)
1,80 beeswax 3050 PHBeeswax
3,20 Tesero-Wachs 30445Microcrystalline wax
3,20 Tesero-Wachs 1030Microcrystalline wax
1,34 CutinaCPCetylpalmitate
6,40 VaselineVaseline oil
7,30 Softisan 100Hydrogenated cocoglyceride
10,00 Luvitol EHOCetearyl ethylhexanoate
0,17 Bisabolol naturalBisabolol
1,84 Vitamin E-acetateTocopherylacetate
0,42 D,L-alpha-tocopherolTocopherol
1% MIP
40,38Castor oil (Ricinus Communis)
A 1,00 UvinulAPIusDiethylaminoethanol-hexylbenzoate
1,00 TinosorbSBis-ethylhexyloxyphenol-methoxyphenylalanine
3,00 UvinulMC80Ethylhexylacrylate
8,00 Miglyol812Caprylic/capric triglyceride
1,50 Dow Corning 350 FluidDimethicone
3,00 Z-COTE MAXTitanium dioxide, aluminum hydroxide, the copolymer of the Dimethicone/Medicon
3,00 FinsolvTNC12-15 alkylbenzoic
1,00 Cremophor CO 40The polyethylene glycol-40 gidrirovannoe castor oil
In 2,00 Luvigel EMCaprylic/capric triglyceride, a copolymer of sodium acrylate
With 54,80 Demineralized waterDemineralized water
D 15,00 Ethanol(96%)Ethanol
5,00 1,2-propylene the eh Care Propylene glycol
0,50 Cremophor A 25Cetearate-25
1,0% MIP
1.00 Vitamin E-acetateTocopherylacetate
0,20 Bisabolol racemicBisabolol
But 25,00 Dow Corning 345 FluidNikopensius, cyclohexasiloxane
20,00 Dow Corning 245 FluidCyclopentasiloxane
8,00 Uvinul MC 80Ethylhexylacrylate
4,00 Abil EM 90Cetil the glycol/polypropylenglycol-10/1 Dimethicone
7,00 T-Lite SF-STitanium dioxide, silicon dioxide hydrate, aluminum hydroxide, the copolymer of Medicon/Dimethicone
In 17,00 ethanol (95%)Ethanol
9,99 Z-COTE MAXZinc oxide (and) diphenylamin-Medicon
5,00 Demineralized waterDemineralized water
3.00 Glycerol (87%) Glycerin
0,01%MIP
1.00 TalcTalc
And 20,00 Dow Corning 345 FluidCyclopentasiloxane, cyclohexasiloxane
10,00 Dow Corning 245 FluidCyclopentasiloxane
7,50 UvinulMCSOEthylhexylacrylate
2,00 UvinulT150Ethylhexylacrylate
12,00 Cosmacol EMIDi-C12-13 altillac
4,00 Abil EM 90Cetil polyethylene glycol/poly-propylene glycol-10/1 Dimethicone
In 7,00 T-Lite SFTitanium dioxide, aluminum hydroxide, the copolymer of the Dimethicone/Medicon
From 15.00 ethanol (95%)Ethanol
10,00 Z-COTE MAXZinc oxide (and) diphenylamin-Medicon
3.00 glycerol (87%)Glycerin
1.5% of MIP
8,00 Demineralized waterDemineralized water
And 10,00 Uvinul A Plus InEthylhexylacrylate, Diethylaminoethanol-hexylbenzoate
10,00 Uvinul N539 TOctocrylene
4,00 EumulginVL75Laurelhurst, polyglyceryl-2 dipolyhydroxystearate, glycerin
8,00 CetiolDibutyltin
8,00 FinsolvTNWith 12-15 alkylbenzoic
12,00 Myntol331Cocoglyceride
1,00 LanetteESodium clearesult
2,00 LanetteOCetearyl alcohol
In 3,00 Z-COTE MAXZinc oxide (and) diphenylamin-Medicon
With 35,08 Demineralized waterDemineralized water
0,38 Citric acidCitric acid
2.9 Glycerol (87%)Glycerin
0,05 Edeta BDDisodium ethylenediaminetetraacetic acid
0.20 Allantoin Allantoin
0,30 KeltrolXanthan gum
0,1% MIP
1,50 Veegum UltraMagnesium aluminum silicate
D 0,50 Phenonip
1.00 Vitamin E-acetateTocopherylacetate

1. Cosmetic or dermatological composition in the form of a cream, foam, spray, gel, gel spray, lotion, oil, oil gel or mousse that contains:
at least one active ingredient,
at least one polymer, molecular imprintirovannymi in the presence of this active substance, and
at least one fatty phase, the polymer contains:
a) monoethylene-unsaturated mono - or dicarboxylic acids or esters of α,β-atilano-unsaturated mono - or dicarboxylic acids with dialami and
b) esters of (meth)acrylic acid at least diatomic alcohols,
moreover, the molar ratio of compounds a) to the compound (b) is from 1:2 to 1:4, and the polymer obtained in the environment of the solvent in which the monomers, but namolocheny the polymer soluble in the presence of the active substance.

2. The composition according to claim 1, whereby the rate of release of active substance from a complex polymer-action is relevant substance with pH, equal to 5, higher than at pH equal to 7.

3. The composition according to claim 1, and the mass ratio of polymer to active substance is from 1:10 to 100:1.



 

Same patents:

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a polyphenol derivative formulation and is used in cosmetics, nutrition science and therapy. The polyphenol derivative formulation possessing antioxidant and antiradical activity and having an effect on carbonyl stress. A method for preparing the formulation. The cosmetic formulation possessing antioxidant and antiradical activity and having an effect on carbonyl stress. Using the formulation in nutrition science. The formulation to be used as a therapeutic agent possessing antioxidant and antiradical activity and having an effect on carbonyl stress. The pharmaceutical formulation possessing antioxidant and antiradical activity and having an effect on carbonyl stress.

EFFECT: formulation has an effect on carbonyl stress.

23 cl, 11 dwg, 5 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to cosmetology and represents an oil-in-water emulsion sun-protection cosmetic composition containing: (A) 1 to 7.5 wt % of octyl methoxycinnamate; (B) 1 to 4 wt % of tret-butyl methoxydibenzoyl methane and/or 2-hydroxy-4-methoxybenzophenone; (C) 0.5 to 3 wt % of a polyoxyethylene/polyoxyalkylene alkyl ester block copolymer; (D) 10 wt % or more of a nonpolar oil relative to the total amount of the oil component; wherein an average emulsion particle diameter makes not more than 700 nm.

EFFECT: invention provides developing the stable sun-protection composition having improved ultraviolet blocking capability and good usability.

4 ex, 4 tbl

FIELD: chemistry.

SUBSTANCE: invention relates to cosmetology, particularly a composition enriched with silver nanoparticles and a method of producing said composition. The composition is intended to replace water as the basic component for producing cosmetic products (shampoos, Balsams, masks, intimate hygiene agents, creams etc). The composition contains a dry 65% whey protein concentrate, a micellar solution of silver nanoparticles in form of an aqueous solution having concentration of 500 mg/l in amount of 0.01-0.5% and additionally water. The method of producing said composition involves heating water to temperature of 50-55°C, adding the whey protein concentrate to the heated water in portions, recirculating the obtained mixture for 15 minutes using a cam-driven pump, adding the micellar solution of silver nanoparticles to the stirred mixture and cooling the obtained mixture to 30°C.

EFFECT: invention enables to obtain cosmetic material which protects skin from inflammatory processes and ageing, controls and maintains the skin water-oil balance.

2 cl, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology, particularly to hair colouring products. The present invention represents a keratin fibre lightener characterised by the fact that it contains in a cosmetic carrier: 4-acetyl-1-methylpyridinium-n-toluene sulphonate, at least one toxicologically sage additional lightening activator and/or a pharmacologically acceptable salt thereof, and hydrogen peroxide.

EFFECT: using the hair lightener according to the invention enables providing the improved blonding ability and reduced hair damage.

13 cl, 2 ex, 5 tbl

FIELD: chemistry.

SUBSTANCE: present inventions relate to protein engineering, plant molecular biology and pest control, as well as a hybrid insecticide protein and use thereof. Described is a hybrid insecticide protein which includes from the N-end to the C-end an N-end portion of Cry3A protein which is fused with the C-end portion of Cry1Ab protein, wherein the position of the crossover of the Cry3A protein and the Cry1Ab protein is located in a conservative block 2, in a conservative block 3 or in a conservative block 4 and has anti-western corn rootworm activity. Also disclosed are nucleic acid molecules which code the novel proteins, methods of producing proteins, methods for use thereof, as well as transgenic plants and seeds thereof which contain such proteins.

EFFECT: inventions enable to obtain cheap means of controlling Diabrotica worms.

39 cl, 8 dwg, 9 tbl, 46 ex

FIELD: chemistry.

SUBSTANCE: claimed invention relates to two-component hair dye, which includes first component, containing alkaline agent, second component, containing hydrogen peroxide, as well as non-aerosol vessel-foaming agent, intended for supply of liquid mixture of first component and second component in form of foam. Said liquid mixture contain anionic SAS, selected from components (A1)-(A3) or components (A4) and (A5), where component (A1) is represented by anionic SAS of carboxylate class, component (A2) is represented by anionic SAS of sulfonate class, component (A3) is represented by anionic SAS of phosphate class, component (A4) is represented by ionic SAS, and component (A5) is represented by alkanolamide of fatty acid. Also claimed invention relates to method of hair dyeing.

EFFECT: invention has good discoloration and dyeing capacities.

22 cl, 4 tbl, 22 ex

FIELD: medicine.

SUBSTANCE: invention refers to production of oral hygiene products. The presented oral care composition contains amorphous quartz having the particle size characterised by the fact that D90 makes less than 50 mcm, and one or more active substance is an antibacterial agent, and specified in a group consisting of cationic antibacterial agents specified in a group consisting of chlorhexidine, cetylpyridinium chloride, bisguanides, benzalkonium chloride, benzethonium chloride; metal salts specified in a group consisting of bivalent stanum salts, zinc salts, copper salts; and combinations thereof.

EFFECT: using amorphous quartz having good compatibility with the above antibacterial properties as a part of the product, particularly a tooth paste, provides storage-stable and high availability of the antibacterial product alongside with the effective and safe cleansing and polishing of the dental tissue.

8 cl, 2 ex, 30 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to preparing a mouthwash containing water, a moisturiser in the amount of 5 wt % to 15 wt % and 0.01 wt % - 5 wt % of a compound presented by the structure (III), wherein R1 and R2 are independently specified in hydrogen atoms, C2-6 -alkenyl group and C1-6 - alkyl group; and the compound (III) is dissolved in ethanol.

EFFECT: invention involves a method for reducing bacterial population on the substrate by substrate contact with the composition containing the compound of the structure (IV), wherein R1 and R2 are independently specified in the substituted or unsubstituted methyl group, substituted or unsubstituted ethyl group and substituted or unsubstituted butyl group.

11 cl, 1 tbl, 5 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to capsule suspensions prepared by coacervation, and to methods for reducing leakage of the capsule content in such suspensions during storage. Substance of the method for reducing leakage of the capsule content consists in storage of the capsules prepared by coacervation, in the capsule suspension containing min. 20 wt %, a moisturiser, which is at least a moisturiser specified in sorbitol, glycerol, polyethylene glycol, propylene glycol, xylitol, erythritol or betaine. What is also presented is the above capsule suspension containing at least one capsule prepared by coacervation and at least 20 wt % of the above moisturiser.

EFFECT: using the above moisturiser in the amount of min 20 wt % provides reducing the leakage rate of the capsule content.

21 cl, 4 tbl, 2 ex, 2 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry and represents a method for preparing a soft tissue filler composition, involving the stages as follows: preparing a HA (hyaluronic acid) ingredient cross-linked with at least one cross-linking agent specified in a group of 1,4-butanediol diglycidyl ether (BDDE), 1,4-bis(2.3-epoxypropoxy)butane, 1,4-bisglycidyl dioxybutane. 1,2-bis(2,3-epoxypropoxy)ethylene and 1-(2,3-epoxypropyl)-2,3 epoxycyclohexane; reducing pH of the above HA ingredient to more than approximately 7.2; and adding the solution containing lidocaine to the above HA ingredient having reduced pH as specified above to prepare the above soft tissue filler composition.

EFFECT: invention provides better stability and cohesion.

12 cl, 5 ex, 3 tbl, 9 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to a composition for treating or preventing an inflammation. What is described is using a primary composition containing a planch suspension in milk or a carrier containing a milk protein, however containing no insoluble fibres for preparing a product for treating or preventing the inflammation.

EFFECT: composition is effective for treating or preventing the inflammation.

14 cl, 13 dwg, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a polyphenol derivative formulation and is used in cosmetics, nutrition science and therapy. The polyphenol derivative formulation possessing antioxidant and antiradical activity and having an effect on carbonyl stress. A method for preparing the formulation. The cosmetic formulation possessing antioxidant and antiradical activity and having an effect on carbonyl stress. Using the formulation in nutrition science. The formulation to be used as a therapeutic agent possessing antioxidant and antiradical activity and having an effect on carbonyl stress. The pharmaceutical formulation possessing antioxidant and antiradical activity and having an effect on carbonyl stress.

EFFECT: formulation has an effect on carbonyl stress.

23 cl, 11 dwg, 5 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to cosmetology and represents an oil-in-water emulsion sun-protection cosmetic composition containing: (A) 1 to 7.5 wt % of octyl methoxycinnamate; (B) 1 to 4 wt % of tret-butyl methoxydibenzoyl methane and/or 2-hydroxy-4-methoxybenzophenone; (C) 0.5 to 3 wt % of a polyoxyethylene/polyoxyalkylene alkyl ester block copolymer; (D) 10 wt % or more of a nonpolar oil relative to the total amount of the oil component; wherein an average emulsion particle diameter makes not more than 700 nm.

EFFECT: invention provides developing the stable sun-protection composition having improved ultraviolet blocking capability and good usability.

4 ex, 4 tbl

FIELD: biotechnologies.

SUBSTANCE: proposed method provides for preparation of inoculating mycelium of basidiomycete, which has been chosen from the following groups: Flammulina velutipes (Curtis) Singer and/or Hericium erinaceus (Bull.) Pers. Preparation of culture medium containing pulverised cold-pressed sunflower cake, soya flour, potassium dihydrogen phosphate, magnesium sulphate and water in the specified ratios. Inoculation of the obtained culture medium with the inoculating mycelium of basidiomycete, cultivation of basidiomycete with further separation of mycelium biomass and extraction of an antitumour agent from the biomass.

EFFECT: invention allows improving an environmental situation due to utilisation of production wastes of food industry.

3 cl, 1 tbl, 4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely saxifragant herbal tea. The saxifragant herbal tea contains meadowsweet root, sunflower root, sloe root, wild rose root, as well as agrimony and wild carrot seeds; all roots are milled, all the ingredients are taken in equal proportions.

EFFECT: herbal tea has the improved saxifragant and calculus-excretion properties.

2 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, and aims at treating patient's oral diseases. Cultured tissue constructs of fibroblast dermal cells are implanted onto the oral tissue. The cultured tissue constructs comprise the cultured cells and endogenous-produced extracellular matrix components without the exogenous matrix or network sustaining or scaffold links.

EFFECT: group of inventions enables providing more simple and less painful treatment of the oral diseases requiring the implanted tissue constructs to be used.

33 cl, 36 ex, 21 dwg

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology, particularly to hair colouring products. The present invention represents a keratin fibre lightener characterised by the fact that it contains in a cosmetic carrier: 4-acetyl-1-methylpyridinium-n-toluene sulphonate, at least one toxicologically sage additional lightening activator and/or a pharmacologically acceptable salt thereof, and hydrogen peroxide.

EFFECT: using the hair lightener according to the invention enables providing the improved blonding ability and reduced hair damage.

13 cl, 2 ex, 5 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, more specifically to pharmacology, neurology and cell engineering. What is described is using Napelline as a cerebroprotective agent. The mode of action of the agent is activation of cerebral neural stem cells.

EFFECT: invention achieves extending the range of high-effective cereroprotective agents.

3 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, specifically to an agent showing antimicrobial activity.

EFFECT: agent possessing antimicrobial action and representing robinia (Robinia pseudaacacia L) seed essence prepared by collecting the seeds in October and extracting them three times in petroleum benzene under certain conditions.

2 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely preparing an agent of hindu lotus seed extract (Nelumbo nucifera) possessing anxiolytic and antidepressive action. The agent possessing anxiolytic and antidepressive action prepared by extraction of hindu lotus seed extract (Nelumbo nucifera) in 50% ethanol in a Soxhlet extraction apparatus in the specific proportions.

EFFECT: agent possess the effective anxiolytic and antidepressive action.

3 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine. A composition for treating an ear disease is introduced into the tympanic cavity, contains a polyoxyethylene-polyoxypropylene copolymer, an active substance specified in an immunomodulator, a vasopressin antagonist, an ion channel antagonist, a neurokinin receptor antagonist, a serotonin reuptake inhibitor, an NMDA-receptor antagonist, a prostaglandin analogue, a preparation having an effect on the central nervous system, a GABA receptor modulator, a cytotoxic agent, an antioxidant, a glutamate receptor modulator or a calcineurin inhibitor.

EFFECT: invention provides the prolonged release of the active substance into the internal ear for a period of time of at least 7 days.

14 cl, 3 dwg, 114 ex

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