Oil-in-water emulsion sun-protection cosmetic composition

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to cosmetology and represents an oil-in-water emulsion sun-protection cosmetic composition containing: (A) 1 to 7.5 wt % of octyl methoxycinnamate; (B) 1 to 4 wt % of tret-butyl methoxydibenzoyl methane and/or 2-hydroxy-4-methoxybenzophenone; (C) 0.5 to 3 wt % of a polyoxyethylene/polyoxyalkylene alkyl ester block copolymer; (D) 10 wt % or more of a nonpolar oil relative to the total amount of the oil component; wherein an average emulsion particle diameter makes not more than 700 nm.

EFFECT: invention provides developing the stable sun-protection composition having improved ultraviolet blocking capability and good usability.

4 ex, 4 tbl

 

The technical FIELD

The present invention relates to compositions in the form of an emulsion oil-in-water. More specifically it relates to a sunscreen cosmetic composition in the form of an emulsion oil-in-water, which shows an excellent ability to protect from UV rays due to the stable content of the absorbent UV rays, that is, by selecting and adding the combination of a particular absorbent of ultraviolet rays, the surface-active agent with a specific structure and a non-polar oil, and, at the same time, has good consumer properties.

PRIOR art

Sunscreen cosmetic composition cuts off ultraviolet rays emitted by the sun, and, therefore, it is used to protect the skin from the harmful effects caused by ultraviolet rays. The main types of cosmetic compositions include emulsion type, lotion and oil type. Of them are widely used emulsion oil-in-water, because it gives the feeling of moisture in the application, and it can be incorporated into a wide variety of tools, including the tool with a low SPF (sunscreen factor) and a product with a high SPF (non-patent document 1).

When this absorbent UV rays, add in sunscreen cosmetic composition, are classified into maslorastvorimye the type and water type. In this regard, in order to obtain high protection, based on the absorption of ultraviolet rays in the UVA (wavelength from 320 to 400 nm) and UVB (wavelength from 290 to 320 nm), you must add absorbent UVB and absorbent UFA with a good balance between them.

However, in order to improve the protective capacity against UV rays by adding a large amount of oil-soluble absorbent of ultraviolet rays, the surface-active agent should also be used in a large quantity, to ensure the stability of the emulsion. As a result, there is a problem in the application, such as the sensation of oiliness and stickiness. In particular, the absorbent UFA has a low emulsion stability at high concentration in oil.

For example, in patent document 1 describes that due to the use of polysaccharide derivatives having a specific group of Deputy, polyols and non-ionic surface-active agent with products HLB of 4 to 9 in combination with an oil component for stable add substances with low solubility in the composition in the form of emulsions of oil-in-water emulsion particles can be more thin and homogeneous dispersed in comparison with the conventional methods. However, absorbent of ultraviolet rays is not discussed as a substance with low solubility.

In patent document 2 describes a cosmetic composition in the form of emulsions of oil-in-water, which contains various stably dispersed oil components and has a good sense of calming and moisturizing effect on the skin, through the use of castor oil polyoxyethylene-additive type and complex ester sorbitan and fatty acid polyoxyethylene-additive type as the emulsifying agent. However, absorbent of ultraviolet rays is not discussed as an added oil component.

In patent document 3 describes a sunscreen composition in the form of an emulsion containing a screening agent for ultraviolet rays on the basis of 4,4-derivative, which is prepared by adding particles of ionic polymer instead of using a surface-active agent, in which a drop of oil has a diameter of 500 nm or less.

The DOCUMENTS of the PRIOR art,

PATENT DOCUMENTS

Patent document 1: JP-A 2006-182724

Patent document 2: JP-A10-95707

Patent document 3: JP-A 2004-315532

Non-PATENT LITERATURE

Non-patent document 1: "New Cosmetic Science, 2nd edition", Takeo Mitsui, Nanzando, 2001, pp 497-504

SUMMARY of the INVENTION

TASKS THAT SHOULD BE SOLVED by the INVENTION

The invention is designed in such circumstances, and the purpose of the invention is to develop a sunscreen cosmetic composition in the form of an emulsion oil-in-water, which has a superior ability to protect from UV rays due to the content of a large number of absorbent of ultraviolet rays, thus having excellent emulsion stability and good consumer properties.

MEANS of SOLVING the PROBLEM

To solve the above problems, the inventors conducted intensive studies. In the result it was found that by selecting tert-butylperoxybenzoate and/or 2-hydroxy-4-methoxybenzophenone as an absorbent of ultraviolet rays in addition to octylmethoxycinnamate and by using combinations of surface-active agent with a specific structure and a non-polar oil, so that the average diameter of the emulsion particles was 700 nm or less, the ability to protect against UV rays can be improved, and the stability is preserved. The invention is made accordingly.

Thus, in the present invention proposed sunscreen cosmetic composition in the form of emulsions of oil-in-water containing

(A) from 1 to 7.5 wt.% octylmethoxycinnamate,

(B) from 0.5 to 4 wt.% mpem-butylperoxybenzoate and/or 2-hydroxy-4-methoxybenzophenone,

(C) from 0.5 to 3 wt.% the block copolymer of polyoxyethylene/polyoxyethyleneglycol ether which is represented by the following formula (1) or who (2):

R1O-(AO)m-(EO)n-H(1)

where in the formula (1) R1represents a hydrocarbon group having from 16 to 18 carbon atoms, AO is an oxyalkylene group having 3 to 4 carbon atoms, EO represents oxyethylene group, AO and EO are connected in block form, each type represents the average number of moles join AO and EO, respectively, and m>4, n>10 and n>m;

R2O-(AO)p-(EO)q-R3(2)

where in the formula (2) R2and R3that may be the same or different from each other, each represents a hydrocarbon group having from 1 to 4 carbon atoms, AO is an oxyalkylene group having 3 to 4 carbon atoms, EO represents oxyethylene group is About and SW are connected in block form, each of p and q represents the average number of moles join AO and EO, respectively, and 1≤R≤70, 1≤q≤70 and 0.2<(q/(p+q))<0.8 a, and

(D) 10 wt.% or more non-polar oils total oil component,

where the average diameter of emulsion particles is 700 nm or less.

The EFFECTS of the INVENTION

Because a large number of absorbent of ultraviolet rays, which is believed to be possessing a weak emulsion stability can be stably added to sunscreen composition in the form of emulsions of oil-in-water according to the invention, the cosmetic composition according to the invention exhibits an excellent ability to protect from UV rays. In addition, the cosmetic composition according to the invention also has excellent application properties, because it gives the feeling of moisture without stickiness.

Forms of carrying out the INVENTION

The composition in the form of emulsions of oil-in-water according to the invention contains octylmethoxycinnamate (ethylhexylacrylate) (i.e. component A). Octylmethoxycinnamate is absorbent of ultraviolet rays (UVB), which is present in the form of butter at room temperature. In accordance with the invention can be used, for example, commercially available products such as "PARSOL MCX" (trade name; manufactured by the company DSM Nutrition Japan K. K.).

D. balaenae number of octylmethoxycinnamate in the composition of the invention ranges from 1 to 7.5 wt.%, preferably from 2 to 7 wt.% and more preferably from 4 to 6 wt.%. When the added amount is less than 1 wt.%, don't get the absorption of ultraviolet rays at a sufficient level. On the other hand, when it is used in quantities of more than 7.5 wt.%, the feeling in the application (i.e. stickiness and stability are prone to deterioration.

Cosmetic composition in the form of emulsions of oil-in-water according to the invention is characterized by the content of tert-butylperoxybenzoate and/or 2-hydroxy-4-methoxybenzophenone (i.e. component B) in addition to octylmethoxycinnamate (component A).

As tert-butylperoxybenzoate, and 2-hydroxy-4-methoxybenzophenone are absorbers of ultraviolet rays (UVA), and each of them is commercially available as PARSOL 1789" (trade name; manufactured by the company DSM Nutrition Japan K. K.) and "Uvinul M40" (trade name; manufactured by BASF K. K.), respectively. These commercially available products can also be used for the invention.

The total added amount of tert-butylperoxybenzoate and/or 2-hydroxy-4-methoxybenzophenone in the cosmetic compositions according to the invention is from 0.5 to 4 wt.%, preferably from 1 to 4 wt.%, and more preferably from 1.5 to 3 wt.%, where in both cases they are used separately, or used in the form of their CME is I. When the added amount is less than 0.5 wt.%, don't get the absorption of ultraviolet rays at a sufficient level. On the other hand, when it is used in more than 4 wt.%, stability is prone to deterioration.

Cosmetic composition according to the invention is characterized in that it uses at least one of the block copolymers of polyoxyethylene/polyoxyethyleneglycol ether (in this application below entitled "block copolymer"), represented by the following formula (1) or (2)as an emulsifying agent.

R1O-(AO)m-(EO)n-H(1)

In the formula (1) R1represents a hydrocarbon group having from 16 to 18 carbon atoms, and preferably saturated or unsaturated aliphatic hydrocarbon group. Its examples include palmityl, stearyl, isostearyl, oleyl and linoleyl.

AO is an oxyalkylene group having 3 to 4 carbon atoms, and its examples include oxypropylene group and oxybutylene group. SW is oxyethylene group.

p> In the formula (1) AO and EO must be linked in block form. If they are connected in statistical form, do not receive the stability of the composition at a sufficient level. The procedure of connection of accelerated and ethylene oxide is not specifically specified. In addition, modular form includes not only the two-stage unit, but also the three-block or higher.

m and n represent the average number of moles of joining the RA and EO, respectively, and m>4, n>10 and n>m.

The molecular weight of the block copolymer of formula (1) is preferably 800 or more, and more preferably 1500 or more. When the molecular weight is less than 800, the effect is low. In addition, although the upper limit of molecular weight is not specifically limited, there is a possibility to get the feeling of stickiness accordingly, the increase in molecular weight.

As the block copolymer represented by the formula (1), you can use a commercially available product NIKKOL RS (trade name; manufactured by the company Nikko Chemicals Co., Ltd.).

R2O-(AO)p-(EO)q-R3(1)

In the formula (2) R2and R3that may be the same or different from each other, each represents a hydrocarbon group having from 1 to 4 carbon atoms, and preferably a saturated aliphatic hydrocarbon group. Its examples include methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl and tert-butyl. More preferably it is a methyl or ethyl.

AO is an oxyalkylene group having 3 to 4 carbon atoms, and its examples include oxypropylene group and oxybutylene group. SW is oxyethylene group.

In the formula (2) AO and EO are connected in block form. If they are connected in statistical form, do not receive the stability of the composition at a sufficient level. The procedure of connection of accelerated and ethylene oxide is not specifically specified. In addition, modular form includes not only the two-stage unit, but also the three-block or higher.

p and q represent the average number of moles of joining the RA and EO, respectively, and 1≤R≤70, 1≤q≤70 and 0.2<(q/(p+q))<0,8.

The molecular weight of the block copolymer of the formula (2) is preferably 1,000 or more, and more preferably 3000 or more. When the molecular weight is less than 1000, the effect is low. In addition, although the upper limit of the molecular weight of the spiral is but not limited to, there is a possibility to get the feeling of stickiness accordingly, the increase in molecular weight.

The block copolymer of the formula (2) can be obtained in accordance with the method known in the art. For example, it can be obtained by carrying out addition polymerization of compounds having a hydroxy-group, with ethylene oxide and alkalization having 3 to 4 carbon atoms, and then carrying out the interaction of simple ether with alkylhalogenide in the presence of an alkaline catalyst (see, for example, JP-A 2004-83541).

Specific examples of the block copolymer of the formula (2) include POE (14) POP (7) dimethyl ether, POE (17) POP (4) dimethyl ether, POE (10) POP (10) dimethyl ether, POE (7) POP (12) dimethyl ether, POE (15) POP (5) dimethyl ether, POE (25) POP (25) dimethyl ether, POE (27) POP (14) dimethyl ether, POE (55) POP (28) dimethyl ether, POE (22) POP (40) dimethyl ether, POE (35) POP (40) dimethyl ether, POE (50) POP (40) dimethyl ether, POE (36) POP (41) dimethyl ether, POE (55) POP (30) dimethyl ether, POE (30) POP (34) dimethyl ether, POE (25) POP (30) dimethyl ether, POE (14) DITCH (7) dimethyl ether, POE (10) POP (10) diethyl ether, POE (10) POP (10) DIPROPYLENE ether and POE (10) POP (10) disutility ether.

While POE, POP and DITCH are abbreviations of polyoxyethylene, polyoxypropylene and polyoxyethylene, respectively.

Add the number of the block with the polymer (i.e. component C) is from 0.5 to 3 wt.%, preferably from 0.5 to 2 wt.% and more preferably from 0.5 to 1 wt.% in the composition. Because small amounts of the block copolymer is sufficient to finely and stably emulsify the oil phase containing the component (a) and component (B)can be obtained a stable composition in the form of emulsions of oil-in-water, non-stickiness caused by surface-active agent. However, when it is used in too small quantity, a stable composition in the form of emulsions of oil-in-water may not be easily obtained. On the other hand, when it is used in an excessive amount, there is a tendency that easily invoked the feeling of stickiness.

Cosmetic composition according to the invention also contains a non-polar oil (i.e. component (D) in an amount of 10 wt.% or more, and preferably 20 wt.% or more of the total mass of oil components.

In accordance with the invention, non-polar oil preferably is an oil, commonly known as non-polar or weakly polar oil, and is not specifically limited. For example, it is selected from hydrocarbon oils, such as hydrogenated polydecene, mineral oil and squalene.

Cosmetic composition in the form of emulsions of oil-in-water according to the invention is also characterized by the fact that the oil phase has an average diameter of emulsionable not more than 700 nm. When the particle diameter exceeds 700 nm, there is a tendency that the stability of the drug or the feeling when applying deteriorating.

As the emulsification method can be used any way, if the oil phase is finely emulsified up to 700 nm or less. Examples of this method include a high-pressure emulsification or microemulsion, which is used as the hydrophilic solvent, such as polyhydric alcohol, in the presence (or absence) of a small amount of water (for example, publication of Japanese patent application No. 57-29213 and JP-A No. 2006-182724), but are not limited to them.

The specific examples of the production method, which can be useful, include a method comprising mixing a portion of the water component of the oil phase and emulsifying agent, emulsification by using emulsion high pressure machine and adding and mixing the other components, and the method including mixing a part of the aqueous phase and emulsifying agent, adding to the mixture solution, in which added and dissolved oil component, their emulsification by using a mixer-homogenizer and adding and mixing the other components to the resulting emulsified product.

In addition to the essential components described above, in a cosmetic composition for izopet which of you can add other components, you can add in a cosmetic composition, if the effect of the invention is not particularly disturbed. Examples of other components that can it is advisable to add, if necessary, include powdery component, a liquid oil components, solid oil components, beeswax, hydrocarbons, higher fatty acids, higher alcohols, esters, silicones, anionic surface-active agent, cationic surface-active agent, amphoteric surface-active agent, nonionic surface-active agent, a moisturizing agent, a water-soluble polymer, an agent that improves adhesion, film forming agent, absorbent of ultraviolet rays, the agent, the scattering ultraviolet rays, agent, sequestrectomy metal ions, lower alcohols, polyhydric alcohols, sugar, amino acids, organic amines, polymer emulsions, agent, regulating pH, nutrient for skin, vitamins, anti-oxidant agent, anti-oxidant additive, aromatic substance and water.

Cosmetic composition according to the invention may contain organic absorbent of ultraviolet rays other than the component (a) and component (b)described above. Examples of organic absorbent of ultraviolet rays, which can be added include absorbent of ultraviolet rays on mass the th basis which is usually used for cosmetic compositions. Specific examples include absorbent of ultraviolet rays on the basis of triazine (for example, bertoncelli); ochiltree (2,4,6-Tris[4-(2-ethylhexyloxymethyl)aniline]1,3,5-triazine); absorbent of ultraviolet rays on the basis of benzoic acid (for example, Lara-aminobenzoic acid (below in this application is called RAWA), RAV monoglyceride ether, N,N-dipropoxy-RAVA-ethyl ester, N,N-diethoxy-RAVA-ethyl ester, N,N-dimethyl-RAVA-ethyl ester, N,N-dimethyl-RAV-butyl ether and N,N-dimethyl-RAVA-ethyl ether); an absorbent of ultraviolet rays on the basis of Anthranilic acid (for example, gommendy-N-acetylanthranilic); absorbent of ultraviolet rays on the basis of salicylic acid (for example, abililities, methylsalicylate, homogentisate, octisalate, fenilsalitsilat, benzalkonium and Lara-isopropylaniline); 3-(4'-methylbenzylidene)-d,I-camphor, 3-benzylidene-d,I-camphor; 2-phenyl-5-methylbenzimidazole; 2,2'-hydroxy-5-methylphenanthrene; 2-(2'-hydroxy-5'-tert-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenanthrene; depenalised; diacetylated; 4-methoxy-4'-tert-butylbenzoate; 5-(3,3-dimethyl-2-norbornene)-3-pentane-2-it, methylenebismethacrylamide and 4,4'-derivatives.

Cosmetic composition in the form of what mulshi oil-in-water according to the invention can be used for various cosmetic compositions, which require sunglasses activity, and therefore, it can be applied not only to the emulsion, cream, song, cosmetic bases, but also for cosmetics, makeup, such as Foundation and lipstick.

Cosmetic composition according to the invention has the feeling of moisture in the application, which is inherent in the composition in the form of an emulsion oil-in-water, and exhibits an excellent ability to protect from UV rays. As such, it is particularly suitable for use as a sunscreen cosmetic composition in the form of an emulsion oil-in-water.

EXAMPLES

Below in this application the invention is explained in more detail in the light of the specific examples. However, the invention is not limited to the following Examples. In addition, the added amount referred to in the Examples below, indicated in wt.%, unless specifically provided otherwise.

Examples and Comparative examples

Composition in the form of an emulsion having the composition described in the following table 1, were prepared and evaluated based on the characteristics described below.

Items of assessment:

(1) the stability of the emulsion

The test sample was stored for 1 month at 50°C. After that, the appearance was observed with the naked eye and evaluated based on the criteria below.

A: no girn the industry or the formation of cream,

×: there are fat or the formation of cream.

(2) the Average diameter of the emulsion particles

The distribution of emulsion particle size was measured immediately after preparation of the composition by using a Zetasizer Nano ZS (trade name, manufactured by the company SYSMEX Corporation). The table description of "same or higher" and "less or the same" pose "of 700 nm or higher and 700 nm or below, respectively, which are obtained in accordance with the observation by the naked eye.

(3) the Feeling in use (stickiness)

Twenty women, professional members of the Commission for quality assessment, put each song on his face with his hand. After /they asked questions about stickiness, when the composition is absorbed into the skin, and the evaluation was performed based on the following criteria.

A: Sixteen or more members of the Commission found no trace of stickiness.

Δ: From six to fifteen members of the Commission had found no trace of stickiness.

×: Five or fewer members of the Commission found no trace of stickiness.

(4) the Ability to protect from UV rays

The ability to protect from UV rays of each composition was measured in vitro by using a spectrophotometer U-4100 (trade name, manufactured by Hitachi Ltd.) and evaluated on the basis of the following criteria.

High: the Absorption at 310 nm is higher than for the standard sample (value measurement in vivo for SPF30).

Standard (STD): Absorption at 310 nm is higher than for the standard sample (value measurement in vivo for SPF16).

Low: the Absorption at 310 nm is lower than for the standard sample (value measurement in vivo for SPF16).

(5) the Stability of dissolution

The oil components of each composition was dissolved and kept at low temperature (0°C) for 1 month. After this precipitation was observed by naked eye and evaluated based on the following criteria.

A: no deposition of crystals.

×: the crystals are precipitated.

Table 1
Example 1Example 2Example 3Example 4EUR. Example 1-1EUR. Example 1-2
WaterRestRestRestRestRestRest
Ethanol6 66666
Octylmethoxycinnamate5555-5
2-Hydroxy-4-methoxybenzophenone-2----
4-mpem-Butyl-4'-methoxydibenzoylmethane2-222-
Dipropyleneglycol333333
Ethylhexylacrylate111111
Glycerin1 11111
Silicon dioxide111111
BCP-8 ceteth-200,8-0,80,80,80,8
PEG/BCP-50/40 dimethyl ether-0,8----
Hydrogenated polydecene33-5--
Mineral oil--3---
Diisopropylamine2 22222
Ezoterikova acid0,20,20,20,20,20,2
Carbomer0,130,130,130,130,130,13
Copolymer of acrylic acid and alkyl (C10-C30) acrylate0,070,070,070,070,070,07
Trisodium edetate0,020,020,020,020,020,02
OSH0,0040,0040,0040,0040,0040,004
Phenoxyethanol 0,30,30,30,30,30,3
Methylparaben0,150,150,150,150,150,15
The stability of the emulsionOAboutAboutAboutAboutAbout
The diameter of the emulsion particles (nm)600550600550×The same or below
The feeling in use (stickiness)aboutAboutAboutAboutAboutAbout
The ability to protect against harmful UV raysSTDSTD--LowLow
The stability of dissolutionAboutAboutaboutAbout×About

The oil component (i.e. hydrogenated polybutene or mineral oil) composition of Example 1 shown in table 1, was replaced by oil, described in the following table 2, and the characteristics were evaluated in the same manner as described above.

-
Table 2
EUR. Example 2-1EUR. Example 2-2EUR. Example 2-3EUR. Example 2-4EUR. Example 2-5EUR. Example 2-6
Triethylhexanoin3----
Isopropylmyristate-3----
Tetracylcine--3---
Ethylhexylamine---3--
Diphenylsilane-denitritation----3-
The stability of the emulsionΔΔΔΔ× ×
The diameter of the emulsion particles (nm)11009501040120020003000
The feeling in use (stickiness)AboutAboutAboutAboutAboutAbout
The ability to protect against harmful UV rays------
The stability of dissolutionAboutAboutAboutAboutAboutAbout

Surface-active agent (i.e. BCP-8 ceteth-20 or PEG/BCP-50/40 dimethyl ether composition of Example 1 shown in table 1, were replaced by surface-active agent, are described in the following table 3, and the characteristics were evaluated in the same manner as described above.

The feeling in use (stickiness)
Tab the Itza 3
EUR. Example 3-1EUR. Example 3-2EUR. Example 3-3EUR. Example 3-4EUR. Example 3-5
PAGP-35/40 dimethyl ether0,8----
Beheneth-30-0,8---
PEG-60
glycerylmonostearate
--0,8--
PEG-60
hydrogenated castor oil
---0,8-
PEG-100 hydrogenated castor oil----0,8
The stability of the emulsionΔΔΔΔΔ
The diameter of the emulsion particles (nm)10001000168013201000
The feeling in use (stickiness)ΔΔΔΔΔ
The ability to protect against harmful UV rays-----
The stability of dissolutionAboutOAboutAboutAbout
Against, Example 3-6Against, Example 3-7Against, Example 3-8 Against, Example 3-9
PEG-30 soy Sterol0,8
Dihydrocholeth-30 (coat)0,8
Polysorbate 600,8
Polysorbate 200,8
The stability of the emulsionΔΔ××
The diameter of the emulsion particles (nm)12501250The same or higherThe same or higher
ΔΔ××
The ability to protect against harmful UV rays----
The stability of dissolutionAboutAboutAboutAbout

Add the amount of each essential component of the composition of Example 1 shown in table 1, was replaced by a quantity that is described in the following table 4, and the characteristics were evaluated in the same manner as 5 described above.

Table 4
Against.Against.Against.Against.Against.
ExampleExampleExampleExample
4-14-24-34-44-5
Octylmethoxycinnamate557,655
2-Hydroxy-4 - methoxybenzophenone5,1---0,5
4-tert-Butyl-4'-methoxydibenzoylmethane-5,122-
BCP-8 ceteth-200,80,80,83,10,8
Hydrogenated polydecene33333
The stability of the emulsion×××OAbout
The diameter of the emulsion particles (nm)The same or higherThe same or belowThe same or higherThe same or belowThe same or below
The feeling in use (stickiness)AboutAboutΔΔΔ
The ability to protect against harmful UV raysHighHighHigh-Low
The stability of dissolutionΔΔΔΔAbout
EUR. Example 4-6EUR. Example 4-7EUR. Note the p 4-8 EUR. Example 4-9
Octylmethoxycinnamate50,955
2-Hydroxy-4-methoxybenzophenone----
4-tert-Butyl-4'-methoxydibenzoylmethane0,5222
BCP-8 ceteth-200,80,80,40,8
Hydrogenated polydecene3331
The stability of the emulsion AboutAboutΔΔ
The diameter of the emulsion particles (nm)The same or belowThe same or higherThe same or higher1040
The feeling in use (stickiness)ΔΔAboutAbout
The ability to protect against harmful UV raysLowLow--
The stability of dissolutionAboutΔAboutAbout

As clearly shown in the above results, a cosmetic composition in the form of emulsions of oil-in-water according to the invention may not provide sufficient ability to protect against UV rays, and 5 shows weak stability when any of octylmethoxycinnamate or tert-butylperoxide antillana and/or 2-hydroxy-4-methoxybenzophenone not include, or they are contained in a quantity smaller than a predetermined amount. On the other hand, when any of these substances include in an excessive amount, there is a tendency that the stability reduced, while the ability to protect against UV rays improves.

In addition, there is also a tendency that the stability decreases when the non-polar oil is not added in sufficient quantity.

In addition, when a block copolymer with a specific structure is not used or is used in a quantity smaller than a predetermined amount, the average diameter of the emulsion particles of 700 nm or less do not receive, and stability is also destroyed.

Sunscreen cosmetic composition in the form of emulsions of oil-in-water containing:
(A) from 1 to 7.5 wt.% octylmethoxycinnamate;
(B) from 1 to 4 wt.% tert-butylperoxybenzoate and/or 2-hydroxy-4-methoxybenzophenone;
(C) from 0.5 to 3 wt.% the block copolymer of polyoxyethylene/polyoxyethyleneglycol ether which is represented by the following formula (1) or (2):
R1O-(AO)m-(EO)n-H(1),
where in the formula (1) R1represents a hydrocarbon group having from 16 to 18 carbon atoms, AO is an oxyalkylene group having 3 to 4 carbon atoms, EO represents oxyethylene group, AO and EO are connected in block form, each of m and n represents the average number of moles join AO and EO, respectively, and m>4, n>10 and n>m;
R2O-(AO)p-(EO)q-R3(2),
where in the formula (2) R2and R3that may be the same or different from each other, each represents a hydrocarbon group having from 1 to 4 carbon atoms, AO is an oxyalkylene group having 3 to 4 carbon atoms, EO represents oxyethylene group, AO and EO are connected in block form, each of p and q represents the average number of moles join AO and EO, respectively, and 1≤R≤70, 1≤q≤70 and 0.2<(q/(p+q))<0,8; and
(D) 10 wt.% or more non-polar oils on the total amount of the oil component;
where the average diameter of emulsion particles is 700 nm or less.



 

Same patents:

FIELD: chemistry.

SUBSTANCE: invention relates to cosmetology, particularly a composition enriched with silver nanoparticles and a method of producing said composition. The composition is intended to replace water as the basic component for producing cosmetic products (shampoos, Balsams, masks, intimate hygiene agents, creams etc). The composition contains a dry 65% whey protein concentrate, a micellar solution of silver nanoparticles in form of an aqueous solution having concentration of 500 mg/l in amount of 0.01-0.5% and additionally water. The method of producing said composition involves heating water to temperature of 50-55°C, adding the whey protein concentrate to the heated water in portions, recirculating the obtained mixture for 15 minutes using a cam-driven pump, adding the micellar solution of silver nanoparticles to the stirred mixture and cooling the obtained mixture to 30°C.

EFFECT: invention enables to obtain cosmetic material which protects skin from inflammatory processes and ageing, controls and maintains the skin water-oil balance.

2 cl, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology, particularly to hair colouring products. The present invention represents a keratin fibre lightener characterised by the fact that it contains in a cosmetic carrier: 4-acetyl-1-methylpyridinium-n-toluene sulphonate, at least one toxicologically sage additional lightening activator and/or a pharmacologically acceptable salt thereof, and hydrogen peroxide.

EFFECT: using the hair lightener according to the invention enables providing the improved blonding ability and reduced hair damage.

13 cl, 2 ex, 5 tbl

FIELD: chemistry.

SUBSTANCE: present inventions relate to protein engineering, plant molecular biology and pest control, as well as a hybrid insecticide protein and use thereof. Described is a hybrid insecticide protein which includes from the N-end to the C-end an N-end portion of Cry3A protein which is fused with the C-end portion of Cry1Ab protein, wherein the position of the crossover of the Cry3A protein and the Cry1Ab protein is located in a conservative block 2, in a conservative block 3 or in a conservative block 4 and has anti-western corn rootworm activity. Also disclosed are nucleic acid molecules which code the novel proteins, methods of producing proteins, methods for use thereof, as well as transgenic plants and seeds thereof which contain such proteins.

EFFECT: inventions enable to obtain cheap means of controlling Diabrotica worms.

39 cl, 8 dwg, 9 tbl, 46 ex

FIELD: chemistry.

SUBSTANCE: claimed invention relates to two-component hair dye, which includes first component, containing alkaline agent, second component, containing hydrogen peroxide, as well as non-aerosol vessel-foaming agent, intended for supply of liquid mixture of first component and second component in form of foam. Said liquid mixture contain anionic SAS, selected from components (A1)-(A3) or components (A4) and (A5), where component (A1) is represented by anionic SAS of carboxylate class, component (A2) is represented by anionic SAS of sulfonate class, component (A3) is represented by anionic SAS of phosphate class, component (A4) is represented by ionic SAS, and component (A5) is represented by alkanolamide of fatty acid. Also claimed invention relates to method of hair dyeing.

EFFECT: invention has good discoloration and dyeing capacities.

22 cl, 4 tbl, 22 ex

FIELD: medicine.

SUBSTANCE: invention refers to production of oral hygiene products. The presented oral care composition contains amorphous quartz having the particle size characterised by the fact that D90 makes less than 50 mcm, and one or more active substance is an antibacterial agent, and specified in a group consisting of cationic antibacterial agents specified in a group consisting of chlorhexidine, cetylpyridinium chloride, bisguanides, benzalkonium chloride, benzethonium chloride; metal salts specified in a group consisting of bivalent stanum salts, zinc salts, copper salts; and combinations thereof.

EFFECT: using amorphous quartz having good compatibility with the above antibacterial properties as a part of the product, particularly a tooth paste, provides storage-stable and high availability of the antibacterial product alongside with the effective and safe cleansing and polishing of the dental tissue.

8 cl, 2 ex, 30 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to preparing a mouthwash containing water, a moisturiser in the amount of 5 wt % to 15 wt % and 0.01 wt % - 5 wt % of a compound presented by the structure (III), wherein R1 and R2 are independently specified in hydrogen atoms, C2-6 -alkenyl group and C1-6 - alkyl group; and the compound (III) is dissolved in ethanol.

EFFECT: invention involves a method for reducing bacterial population on the substrate by substrate contact with the composition containing the compound of the structure (IV), wherein R1 and R2 are independently specified in the substituted or unsubstituted methyl group, substituted or unsubstituted ethyl group and substituted or unsubstituted butyl group.

11 cl, 1 tbl, 5 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to capsule suspensions prepared by coacervation, and to methods for reducing leakage of the capsule content in such suspensions during storage. Substance of the method for reducing leakage of the capsule content consists in storage of the capsules prepared by coacervation, in the capsule suspension containing min. 20 wt %, a moisturiser, which is at least a moisturiser specified in sorbitol, glycerol, polyethylene glycol, propylene glycol, xylitol, erythritol or betaine. What is also presented is the above capsule suspension containing at least one capsule prepared by coacervation and at least 20 wt % of the above moisturiser.

EFFECT: using the above moisturiser in the amount of min 20 wt % provides reducing the leakage rate of the capsule content.

21 cl, 4 tbl, 2 ex, 2 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry and represents a method for preparing a soft tissue filler composition, involving the stages as follows: preparing a HA (hyaluronic acid) ingredient cross-linked with at least one cross-linking agent specified in a group of 1,4-butanediol diglycidyl ether (BDDE), 1,4-bis(2.3-epoxypropoxy)butane, 1,4-bisglycidyl dioxybutane. 1,2-bis(2,3-epoxypropoxy)ethylene and 1-(2,3-epoxypropyl)-2,3 epoxycyclohexane; reducing pH of the above HA ingredient to more than approximately 7.2; and adding the solution containing lidocaine to the above HA ingredient having reduced pH as specified above to prepare the above soft tissue filler composition.

EFFECT: invention provides better stability and cohesion.

12 cl, 5 ex, 3 tbl, 9 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to oral hygiene and personal hygiene compositions, and more specifically to compositions comprising a film immersed into a carrier, wherein the film contains a relatively high concentration of a zinc compound. According to the invention, the oral hygiene composition comprises the film immersed into the carrier wherein the zinc compound is found in the amount from approximately 35 wt % to approximately 60 wt %.

EFFECT: increase in the solid content in the film enhances the active compound delivery per a unit area that is important to achieve the highest delivery efficiency.

23 cl, 2 dwg, 14 tbl, 8 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to whitening tooth pastes, adducts therefor, and methods for preparing them. The adduct applicable for preparing a whitening formulation is prepared by mixing raw materials comprising peroxide, urea and an alkali metal polyphosphate in aqueous solution in the environment of temperature and/or pressure and/or agitation effective to prepare a solution of raw materials. The relation of (alkali metal polyphosphate) to (peroxide) in the aqueous solution of the adduct is matched with the relation of (anhydrous alkali metal polyphosphate) to (hydrogen peroxide 35 wt/wt % of the concentration) falling within the range of 0.05:1 to 0.5:1, and the adduct has pH in the aqueous solution that increases at least by 1.0 after ten introductions of the solution.

EFFECT: preparing the dental whitening formulation wherein the adduct is found in the aqueous environment, comprises a drug preparation and/or the adduct has pH in the aqueous solution that increases by at least 1,0 after ten introductions of the solution (and hence, in situ in the mouth when in use) that provides the excellent whitening properties thought to be ensured by the release of additional active peroxide ions onto the teeth when in use.

15 cl, 4 ex

FIELD: biotechnologies.

SUBSTANCE: proposed method provides for preparation of inoculating mycelium of basidiomycete, which has been chosen from the following groups: Flammulina velutipes (Curtis) Singer and/or Hericium erinaceus (Bull.) Pers. Preparation of culture medium containing pulverised cold-pressed sunflower cake, soya flour, potassium dihydrogen phosphate, magnesium sulphate and water in the specified ratios. Inoculation of the obtained culture medium with the inoculating mycelium of basidiomycete, cultivation of basidiomycete with further separation of mycelium biomass and extraction of an antitumour agent from the biomass.

EFFECT: invention allows improving an environmental situation due to utilisation of production wastes of food industry.

3 cl, 1 tbl, 4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely saxifragant herbal tea. The saxifragant herbal tea contains meadowsweet root, sunflower root, sloe root, wild rose root, as well as agrimony and wild carrot seeds; all roots are milled, all the ingredients are taken in equal proportions.

EFFECT: herbal tea has the improved saxifragant and calculus-excretion properties.

2 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, and aims at treating patient's oral diseases. Cultured tissue constructs of fibroblast dermal cells are implanted onto the oral tissue. The cultured tissue constructs comprise the cultured cells and endogenous-produced extracellular matrix components without the exogenous matrix or network sustaining or scaffold links.

EFFECT: group of inventions enables providing more simple and less painful treatment of the oral diseases requiring the implanted tissue constructs to be used.

33 cl, 36 ex, 21 dwg

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology, particularly to hair colouring products. The present invention represents a keratin fibre lightener characterised by the fact that it contains in a cosmetic carrier: 4-acetyl-1-methylpyridinium-n-toluene sulphonate, at least one toxicologically sage additional lightening activator and/or a pharmacologically acceptable salt thereof, and hydrogen peroxide.

EFFECT: using the hair lightener according to the invention enables providing the improved blonding ability and reduced hair damage.

13 cl, 2 ex, 5 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, more specifically to pharmacology, neurology and cell engineering. What is described is using Napelline as a cerebroprotective agent. The mode of action of the agent is activation of cerebral neural stem cells.

EFFECT: invention achieves extending the range of high-effective cereroprotective agents.

3 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, specifically to an agent showing antimicrobial activity.

EFFECT: agent possessing antimicrobial action and representing robinia (Robinia pseudaacacia L) seed essence prepared by collecting the seeds in October and extracting them three times in petroleum benzene under certain conditions.

2 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely preparing an agent of hindu lotus seed extract (Nelumbo nucifera) possessing anxiolytic and antidepressive action. The agent possessing anxiolytic and antidepressive action prepared by extraction of hindu lotus seed extract (Nelumbo nucifera) in 50% ethanol in a Soxhlet extraction apparatus in the specific proportions.

EFFECT: agent possess the effective anxiolytic and antidepressive action.

3 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to a method for preparing an enterosorbent. The method for preparing the enterosorbent involving milling birch bark, activating in evaporated water under certain conditions, processing in 0.5-2.0% alkali for 30-60 min, water flushing, nautralising, condensing and drying to the air-dry condition.

EFFECT: enterosorbent prepared by the method described above is characterised by high methylene blue sorption capacity and gelatine sorption capacity.

1 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: declared invention refers to veterinary science, and aims at treating gastrointestinal diseases in calves. A method involves using the subcutaneous injections of convascelent's blood serum containing rota- and coronavirus antihemagglutinin in titres 1:128 and 1:64 respectively. The serum is introduced in a dose of 10.0 ml once a day for 9 days every 48 hours. That is combined with administering an infusion of a milled mixture of equal portions of purple Echinacea herb and blossom clusters (Echinazea purpurea), coltsfoot herb (Tussilago farfara), tillet blossom (Tilia cordata) and liquorice root (Glycyrrhiza glabra) prepared with the relation of the raw material to extractant that is 70% alcohol - 1:10 and kept at temperature 15-20°C for 7 days in the form of 7-8% aqueous solution in a dose of 3.5-4.5 ml/kg of animal's body weight every 12 hours to the clinical recovery.

EFFECT: use of the declared invention provides the higher body resistance and faster recovery of the animal's body micro- and macroelement balance.

5 tbl, 3 ex

Immunomodulator // 2497514

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry, and represents an immunomodulator for treating chronic hepatitis, hepatic cancer, lymphatic sarcoma, chronic leukemia, and for improving the functions of liver and blood-forming organs, for enhancing the immunobiological body characteristics, prepared by mixing 1000 ml of an aqueous infusion of sandy everlasting blossom, pepper mint herb and chicory herb with 50 ml of bovine serum containing leukaemia oncovirus antibodies, 20 ml of wild rosemary infusion, 40 g of ascorbic acid, 2 g of sorbic acid, 0.2 g of folic acid until the ingredients are dissolved completely, with adding 60 g of liver powder, 30 g of lymphatic node powder, 30 g of young bovine spleen powder; the prepared solution is settled at room temperature for 24 hours, then kept at a boiling water bath for 30 minutes and cooled for 6-8 hours at room temperature; the settled solution is filtered, wherein the aqueous herbal solution is prepared by mixing equal proportions of the separately prepared aqueous infusions of 40 g of pepper mint herb in 1000 ml of water, 30 g of sandy everlasting blossom in 1000 ml of water and 30 g of chicory herb in 1000 ml of water, while the wild rosemary infusion is prepared by infusing 60 g of ground wild rosemary blossom in 1000 ml of 70% purified ethanol.

EFFECT: invention provides creating the high-efficacy agent and reducing the length of treatment.

FIELD: medicine, oncology, amino acids.

SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.

EFFECT: valuable medicinal antitumor properties of preparation.

8 cl, 4 tbl, 2 dwg, 4 ex

Up!