Hair lightener containing cationic acylpyridinium derivatives, additional lightening activators and hydrogen peroxide

FIELD: medicine.

SUBSTANCE: invention refers to cosmetology, particularly to hair colouring products. The present invention represents a keratin fibre lightener characterised by the fact that it contains in a cosmetic carrier: 4-acetyl-1-methylpyridinium-n-toluene sulphonate, at least one toxicologically sage additional lightening activator and/or a pharmacologically acceptable salt thereof, and hydrogen peroxide.

EFFECT: using the hair lightener according to the invention enables providing the improved blonding ability and reduced hair damage.

13 cl, 2 ex, 5 tbl

 

The present invention relates to a means for lightening keratin fibers, that is, means for applying to the keratin fibers, particularly human hair, containing cationic derivatives azulfidine, toxicologically safe extra brightening activator action, and hydrogen peroxide, with the aim of lightening the hair, and also the appropriate way.

The change in the shape and color of the hair is an important area of modern cosmetic industry. Due to this appearance of hair can be brought in line with current fashion trends, and individual wishes of the individual. When this chemical Curling and other ways of changing the shape of hair can be used almost independently of the type of hair that needs to be processed. Conversely, methods of colouring and lightening hair is limited to a specific original hair color. The basics of ways to lighten hair known to the specialist, and they can be read related to this topic monographs, for example, in Kh.Schrader, Grundlagen und Rezepturen der Kosmetika, 2nd. Edition, 1989, Dr.Alfred Huthig Verlag, Heidelberg, or W.Umbach (Hrg.), Kosmetik, 2. Edition, 1995, Georg Thieme Verlag, Stuttgart, New York.

In addition to dyeing, bleaching your own hair, or bleaching, is a completely purposeful desire of many needs of the residents, because blond hair is considered attractive and desirable from the point of view of fashion. For this purpose on the market available in various blunderous means having a differing ability to discoloration. These products contain oxidants, due to oxidative destruction of their own colorants hair - melanin, able to lighten the hair fibre. For the average blinderoaxaca effect enough to use as oxidizing means only hydrogen peroxide, optionally with the use of ammonia or other alkalizing agents, to achieve a stronger blinderoaxaca effect usually uses a mixture of hydrogen peroxide and peroxodisulfate salts and/or peroxomonosulfate salts. However, the clarification process is also accompanied by damage to the hair, since oxidation damage is not only the natural components of the hair, giving color, but also other structural components of the hair. Depending on the manifestation of the extent of damage it may be stages from rough, brittle and hard raschesyvaemost hair, to reduced stability and strength of the hair and until the destruction of the hair. The greater the amount of hydrogen peroxide and, if necessary, of peroxodisulfate, so usually, more si is performance communications damage to the keratin fibers appear. Means for coloring or lightening hair that have a good brightening effect without concomitant damage to the hair fibres, it is still not known.

Before their use on human hair hair colour and/or to lighten hair in solid or pasty form is usually mixed with a dilute aqueous solution of hydrogen peroxide. Then this mixture is applied onto hair and after a certain exposure time is again washed away. The duration of exposure of the hair to achieve full coloration or bleaching is a time between about 30 and 40 minutes. It is obvious that for the consumer of these hair dyes or slanderously means there is a need to decrease the time of exposure.

The process of lightening keratin fibers usually occur at the pH in the alkaline region, in particular, between 9.0 and 10.5. These pH required to provide disclosure of the outer layer of scales (the cuticle), and make possible the penetration of active components (intermediate products for coloring substances and/or hydrogen peroxide in the hair. As the alkalizing agent is typically used ammonia, which, however, in relation to the consumer has drawbacks from a sharp odor and possible sec is agenia to skin irritation and skin sensitization.

Although available until now on sale blunderous means, as a rule, exhibit good bleaching ability, they cannot be considered optimal because of hair damage, long time use, and possible skin irritation due to high concentrations of acidifying and alkalizing agents.

The use of cationic derivatives of azulfidine when coloring hair is known, for example, from the publications of the German patents DE 10148845 A1 or DE 10261656 A1. However, in both documents, such derivatives are described in conjunction with at least one second coloring component as a means for coloring, and, consequently, to increase the intensity of staining of the hair. Question of the level of technology is still not clear that these derivatives 4-azulfidine can be used in certain combinations with certain toxicologically safe additional activators brightening action, as well as hydrogen peroxide to bleach hair with very good decolorizing power.

The objective of the invention is to provide a means for clarification or, respectively, of bleaching the hair of a new type, which contains features comparable or superior to conventional means available prodaja, however, have reduced damaging effect on the hair.

So, in a way that was not anticipated, was able to find that using a combination of cationic derivatives of azulfidine having the General structure (I)at least one toxicologically safe extra brightening activator actions, as well as hydrogen peroxide is much stronger lightens hair, than would be possible using comparable amounts of one hydrogen peroxide.

Due to improved bandaraya ability when using the means according to the invention can be reduced by the amount of oxidant, and this can help minimize the damage woloschak through this method it is possible to reduce the time of exposure by achieving the lightening effect corresponding to the effect of the level of technology.

The means according to the invention discolor natural dye - melanin by oxidation. The combination of active substances according to the invention without the presence of additional dyes/intermediates for dyes by visual examination does not form in the keratin fibers a dye substances. Synthetic dyes, already present on the surface or inside the keratin fibers, mo the ut to discolour using the means according to the invention.

Thus, the first subject of this invention is a means for lightening keratin fibers, characterized in that it contains in a cosmetic carrier:

(i) at least one cationic derivative of azulfidine General Formula (I)

in which

R represents an alkyl group with carbon atoms of 1 to 6, alkenylphenol group with the number of carbon atoms from 2 to 6, hydroxyalkyl group with the number of carbon atoms from 2 to 6, alkoxyalkyl group with the number of carbon atoms in the CNS radical of 1 to 6, and the alkyl of 2 to 6, carboxialkilnuyu group with the number of carbon atoms in the alkyl from 1 to 6, arylalkyl group with the number of carbon atoms in the alkyl from 1 to 6, heteroallyl group with the number of carbon atoms in the alkyl from 1 to 6, mono - or di-C1-C6-alkylamino-C2-C6is an alkyl group, 3-oxobutyl group, 2-oxopropyl group, aryl group or heteroaryl group,

R' is an alkyl group with carbon atoms of 1 to 4, hydroxyalkyl group with the number of carbon atoms from 2 to 6 or alkoxyalkyl group with the number of carbon atoms in the CNS radical of 1 to 6, and the alkyl of 2 to 6,

X' is a physiologically acceptable anion,

(ii) at least one toxicologically safe is th additional brightening activator and/or its physiologically acceptable salt, and

(iii) hydrogen peroxide.

Under the keratin fibers or fibers of keratin should be understood fur, wool, feathers, and, above all, human hair. Despite the fact that the tool according to the invention is primarily suitable for dyeing and/or lightening keratin fibers, in principle, nothing prevents its use in other areas.

The following are examples of residues that are listed as substituents in the compounds of Formula (I):

Examples of alkyl residues with the number of carbon atoms from 1 to 6 are group-CH3, -CH2CH3, -CH2CH2CH3, -CH(CH3)2, -CH2CH2CH2CH3, -CH2CH(CH3)2, -CH(CH3)CH2CH3- (CH3)3.

Examples alkenyl groups with the number of carbon atoms from 2 to 6 are prop-2-anilina group (allyl group), 2-methylprop-2-anilina group, but-3-EN ilen group, a but-2-anilina group, Penta-4-anilina group or Penta-3-anilina group. In this context, especially/it is preferable prop-2-anilina group.

Furthermore, as preferable examples of the hydroxyalkyl group with the number of carbon atoms in the alkyl of 2 to 6 can be used-CH2CH2OH, -CH2CH2CH2H, -CH2CH(OH)CH3, -CH2CH2CH2CH2OH, and the group-CH2CH2OH is preferred.

Examples alkoxyalkyl groups with the number of carbon atoms in the CNS radical of 1 to 6, and the alkyl of 2 to 6 are group-CH2CH2OCH3, -CH2CH2CH2OCH3, -CH2CH2OCH2CH3, -CH2CH2CH2OCH2CH3, -CH2CH2OCH(CH3)2, -CH2CH2CH2OCH(CH3)2.

Examples carboxialkilnuyu group with the number of carbon atoms in the alkyl from 1 to 6 are carboxymethyl group, 2-carboxyaniline group or 3-carboxypropyl group.

Examples arylalkyl groups with the number of carbon atoms in the alkyl from 1 to 6 are a benzyl group and 2-phenylethylene group.

Examples heteroarylboronic groups with the number of carbon atoms in the alkyl from 1 to 6 are pyridine-2-ylmethylene group, pyridine-3-ylmethylene group, pyridine-4-ylmethylene group, pyrimidine-2-ylmethylene group, pyrrol-1-ylmethylene group, pyrrol-1-retelny group, a pyrazole-1-ylmethylene group or a pyrazole-1-retelny group.

Examples of mono - or di-C1-C6-alkylamino-C2-C6-alkyl groups are 2-methylaminomethyl group, 2-ethylaminomethyl group, 2-dimethylaminoethyl the group, 2-diethylaminoethyl group, 3-methylaminopropyl group, 3-dimethylaminopropyl group, 1-piperidinoethyl group, 1-pyrrolidinedione group, 4-morpholinoethyl group and 2-bis(2-hydroxyethyl)aminoaniline group, and 2-dimethylaminomethylene group and 2-diethylaminoethyl group are particularly preferred.

Example of the aryl group is a phenyl group, 1-naftalina group or 2-naftalina group.

Examples of heteroaryl groups include pyridine-2-ilen group, pyridine-3-ilen group, pyridine-4-ilen group, pyrimidine-2-ilen group, pyrrol-1-ilen group, pyrrol-2-ilen group, pyrrol-2-ilen group, a pyrazole-1-ilen group, a pyrazole-3-ilen group or a pyrazole-2-ilen group.

The means according to the invention contain at least three main components: at least one cationic derivative of azulfidine Formula (I), at least one toxicologically safe extra brightening activator and/or its physiologically compatible salt, and hydrogen peroxide. The means according to the invention can also provide a "ready-to-use mixture, that is, funds which, although they are present in separate containers (e.g., for reasons of stability), however, before use, mix with each other with education is the use of ready-to-use mixture, and then applied.

Preferably suitable are those compounds of Formula (I)where the remainder R in the General structure (I) represents an alkyl group with carbon atoms of 1 to 6, alkenylphenol group with the number of carbon atoms from 2 to 6 or hydroxyalkyl group with the number of carbon atoms from 2 to 6.

In addition, according to the invention is preferred when the remainder R' in the Formula (I) represents an alkyl group with carbon atoms of 1 to 6, alkenylphenol group with the number of carbon atoms from 2 to 6, hydroxyalkyl group with the number of carbon atoms from 2 to 6 or alkoxyalkyl group with the number of carbon atoms in the CNS radical of 1 to 6, and the alkyl of 2 to 6, especially, alkyl group with carbon atoms of 1 to 6 (preferably methyl, ethyl, n-propyl or isopropyl).

It is preferable if the anion X' according to the Formula (I) is selected from the halides, in particular chloride, bromide or iodide, bansilalpet, p-toluensulfonate, alkylsulfonate with the number of atoms in the alkyl from 1 to 4, triftoratsetata, acetate, triptoreline, perchlorate, sulfate with a molar ratio of½, hydrosulfate, tetrafluoroborate, hexaphosphate or tetrachlorozincate. According to the invention is particularly favorable, if physiologically acceptable anion X"represents the t of a halide ion (in particular, chloride or bromide), hydrosulfate, sulfate with a molar ratio of½, p-toluensulfonate, bansilalpet or acetate.

Particularly preferred cationic derivatives azulfidine General Formula (I) are:

Salts of 4-acetyl-1-methyl-pyridiniumSalts of 4-acetyl-1-ethyl-pyridinium
Salts of 4-acetyl-1-allyl-pyridiniumSalts of 4-acetyl-1-(2-methylprop-2-enyl)-pyridinium
Salts of 4-acetyl-1-(2-hydroxyethyl)-pyridiniumSalts of 4-acetyl-1-benzyl-pyridinium
Salts of 4-acetyl-1-(2-oxopropyl)-pyridiniumSalts of 4-acetyl-1-(2-methoxyethyl)-pyridinium

in which X-accordingly accepts values corresponding preveden the m for structure (I), or values for the above preferred embodiments of the invention.

In summary, preferred according to the invention are means that as a cationic derivative of azulfidine General structure (I) contain at least one compound from the group which consists of:

4-acetyl-1-methylpyridinium-p-toluensulfonate, 4-acetyl-1-methylprednisolone, 4-acetyl-1-methylpyridinium, 4-acetyl-1-methylenetetrahydrofolate, 4-acetyl-1-arylpyrimidine-p-toluensulfonate, 4-acetyl-1-allylisothiocyanate, 4-acetyl-1-arylpyrimidine, 4-acetyl-1-allylpyrocatechol, 4-acetyl-1-(2-hydroxyethyl)pyridine-p-toluensulfonate, 4-acetyl-1-(2-hydroxyethyl)pyridinemethanol, 4-acetyl-1-(2-hydroxyethyl)-pyridineboronic, 4-acetyl-1-(2-hydroxyethyl)pyridinemethanol, 4-acetyl-1-(2-oxopropyl)pyridine-p-toluensulfonate, 4-acetyl-1-(2-oxopropyl)pyridinemethanol, 4-acetyl-1-(2-oxopropyl)pyridineboronic, 4-acetyl-1-(2-oxopropyl)pyridinemethanol, 4-acetyl-1-ethylpyridine-l-toluensulfonate, 4-acetyl-1-ethylenediaminetriacetate, 4-acetyl-1-ethylpyridinium, 4-acetyl-1-ethyleneterephthalate, acetyl-1-(2-methylprop-2-enyl)pyridine-p-toluensulfonate, 4-acetyl-1-(2-methylprop-2-enyl)pyridinemethanol, 4-acetyl-1-(2-methylprop-2-enyl)PIR is minibrain, 4-acetyl-1-(2-methylprop-2-enyl)pyridinemethanol, 4-acetyl-1-benzylpyridine-p-toluensulfonate, 4-acetyl-1-benzilpenitsillina, 4-acetyl-1-benzylpyridine, 4-acetyl-1-benzylbenzimidazole, 4-acetyl-1-(2-methoxyethyl)pyridine-p-toluensulfonate, 4-acetyl-1-(2-methoxyethyl)pyridinemethanol, 4-acetyl-1-(2-methoxyethyl)pyridineboronic, 4-acetyl-1-(2-methoxyethyl)pyridinedicarboxylate.

From this group the following acetylpyridine salt are definitely highly preferred:

4-acetyl-1-methylpyridinium-p-toluensulfonate, 4-acetyl-1-methylprednisolone, 4-acetyl-1-methylpyridinium, 4-acetyl-1-methylenetetrahydrofolate, 4-acetyl-1-arylpyrimidine-p-toluensulfonate, 4-acetyl-1-allylisothiocyanate, 4-acetyl-1-arylpyrimidine, 4-acetyl-1-allylpyrocatechol, 4-acetyl-1-(2-hydroxyethyl)pyridine-p-toluensulfonate, 4-acetyl-1-(2-hydroxyethyl)pyridinemethanol, 4-acetyl-1-(2-hydroxyethyl)pyridineboronic, 4-acetyl-1-(2-hydroxyethyl)pyridinedicarboxylate.

Unless otherwise stated explicitly, all of the following quantitative data refer respectively to the mass percent of the funds ready to use.

As the first important ingredient means according to the invention contain derivative acylpyrin the I of the General structure (I), preferably in quantities of from 0.01 to 25 wt. -%, first of all, from 0.1 to 10 wt. -%, accordingly, calculated on the total weight of tools, ready to use.

As a second important ingredient in the tool according to the invention contains at least one toxicologically safe extra brightening activator and/or its physiologically acceptable salt. Within the scope of this invention as toxicologically safe you should not understand the imidazole.

This toxicologically safe extra brightening activator action, preferably selected from aliphatic and/or carbocyclic additional activators brightening action.

Especially preferably, this toxicologically safe extra brightening activator actions as an important structural distinction contains hydroxyl group, carboxylic acid complex monoether sulfuric acid, complex monoether phosphoric acid and/or their physiologically acceptable salt.

In cases where this toxicologically safe extra brightening activator action contains a structural unit, which allows for multiple spatial configurations, such as, for example, substituted double bond or asymmetric centers, and, of course,within the scope of this invention includes all possible stereoisomers. However, if necessary, according to the invention, it may be preferable to use only one possible stereoisomer or a certain mixture of two or more stereoisomers.

The preferred means according to the invention are characterized in that as an additional brightening activator and/or its physiologically acceptable salts they contain at least one additional brightening activator actions corresponding to the Formula (II), and/or its physiologically acceptable salt,

where

Y represents a carbonyl group, a simple bond or a methylene group,

R1 is a hydrogen atom, alkyl group with carbon atoms of 1 to 4, a physiologically acceptable cation or groups SO3or SO32-,

R2 represents amino, methylamino-, dimethylamino-, trimethylammonium group, phenyl, benzyl, phenoxymethyl, 1-naphthyl, 2-naphthyl, 2-, 3-, 4-toluoyl or R4-O-(CH2CH2O)ngroup, and R4 is an alkyl group with carbon atoms of 6 to 20, and n is the number greater than 15,

R3 represents a hydrogen atom or an optionally branched alkyl group with carbon atoms of 1 to 6,

provided that

if Y is a carbonyl group,

R1 is the I atom of hydrogen, alkyl group with carbon atoms of 1 to 4 or a physiologically acceptable cation,

R2 represents amino, methylamino-, dimethylamino - or trimethylammonio group, and

R3 is a hydrogen atom or an optionally branched alkyl group with carbon atoms of 1 to 6,

and that

if Y is a simple link,

R1 is a hydrogen atom, and

R2 represents phenyl, benzyl, phenoxymethyl, 1-naphthyl, 2-naphthyl, 2-, 3-, 4-tolyl, and

R3 is a hydrogen atom or an optionally branched alkyl group with carbon atoms of 1 to 6,

and that

if Y is a methylene group,

R1 is a group of SO3-or SO32,

R2 R4 represents-O-(CH2CH2O)ngroup, and R4 is an alkyl group with carbon atoms of 6 to 20, and n is the number greater than 15,

and

R3 is a hydrogen atom.

In particular, the preferred means according to the invention are characterized in that as an additional brightening activator actions they contain at least one aliphatic amino acid, optionally N-methylated or N,N-dimitrievna by its nitrogen atom, and/or its physiologically acceptable salt.

Preferred additional asset is the Torah brightening action is selected from glycine, N-methylglycine, N,N-dimethylglycine, alanine, N-methylalanine, N,N-dimethylalanine, leucine, N-methyllysine, N,N-dimethylglycine, isoleucine, N-methylisoleucine, N,N-dimethylhydrazine or their physiologically acceptable salts.

Highly preferred is if the tool according to the invention as an additional activator brightening action contains glycine and/or its physiologically acceptable salt.

The preferred means according to the invention as an additional brightening activator actions contain at least one aromatic alcohol and/or its physiologically acceptable salt.

As preferred according to the invention aromatic alcohols should be benzyl alcohol, 2-phenethyl alcohol, 1-phenethyl alcohol, 2-Phenoxyethanol, 1-hydroxymethylation and/or 2-hydroxymethylation.

Aromatic alcohol, in highly preferred according to the invention as an additional activator brightening action is benzyl alcohol.

And finally, according to the invention preferred may be means such that as additional brightening activator actions contain physiologically acceptable salt sulphate simple Olkiluoto ether corresponding to the Formula (III)

in which R4 represents an alkyl group with carbon atoms of 6 to 20, a m number greater than 15, and Y is an alkaline and/or alkaline earth metal, ammonium ion, alkylammonium or alkanolammonium.

Sulfates simple alilovic esters ("simple ethersulfate") work in industry with the help of sulfation ethers of fatty alcohols or ethers of oxoalcohols under the action of SO3-or chlorosulfonic acid (HSC) and subsequent neutralization. According to the invention, the preferred examples are the sulfates vysokointegrirovannyh products attach at least 16, but, on average, from 20 to 40, and in particular from 25 to 35 mol of ethylene oxide (the amount of which is expressed by m in the Formula (III)) to Caproic alcohol, Caprylic alcohol, 2-ethylhexylamine alcohol, capric alcohol, lauric alcohol, isotridecyl alcohol, militiawoman alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, Aksenova alcohol or their technical mixtures in the form of sodium and/or magnesium salts of these sulfates. These connections are formed, for example, when the hydrogenation at high pressures technical methyl esters based on fats and oils or aldehydes when oxosynthesis on Raelene, and as monomer fraction dim when the polarization of unsaturated fatty alcohols. Preferred are technical fatty alcohols containing from 12 to 18 carbon atoms, such as, for example, coconut fat, palm fatty alcohols, the alcohols from the seeds of the oil palm or animal fat. Simple ethersulfate can have both normal and narrow distribution of homologues. Especially preferred is the use of simple ethersulfate based on the products of attaching an average of 25 to 35 mol of ethylene oxide to technical fractions of coconut fatty alcohol containing from 12/14 to 12/18 carbon atoms, in the form of their sodium and/or magnesium salts.

Especially preferred additional brightening activator actions indicated in the International nomenclature of cosmetic ingredients, INCI as sodium coquette-30 sulfate and comes in a sale by the company Cognis under the trade name of Disponil® FES 77 in the form of an aqueous solution with a concentration of 31-33% of the mass.

Preferably one or more additional activators brightening actions are used in amounts that are within certain limits. According to the invention preferred tools, which contain at least one toxicologically safe extra brightening activator action in the amount of from 0.01 to 10 wt%. and, in particular, from 0.1 to 5 wt. -%, accordingly, in baresch the ones on the total weight of the tool, ready-to-use.

As a third important ingredient in the tool according to the invention contains hydrogen peroxide. Preferably the hydrogen peroxide itself is used in aqueous solution. However, hydrogen peroxide can also be used in the form of solid products of accession of hydrogen peroxide to inorganic or organic compounds, such as, for example, perborate sodium, percarbonate sodium, percarbonate magnesium, percarbonic sodium, polyvinylpyrrolidone*n H2O3(n is a positive integer greater than 0), urea peroxide and melamine peroxide. In the latter case, these addition products release hydrogen peroxide in the mixture according to the invention, ready for use, that is, these funds, in addition to the products of accession, containing in a cosmetic carrier free of hydrogen peroxide.

According to the invention in a highly preferred if the hydrogen peroxide is added to the tool according to the invention in the form of an aqueous solution of hydrogen peroxide. The concentration of the hydrogen peroxide solution is determined, on the one hand, its norms, and, on the other hand, the desired effect; preferably applied solutions in water with a concentration of from 6 to 12% of the mass. According to the invention, the preferred means is and are characterized by they, in terms of their total weight, contain from 0.01 to 12 wt. -%, preferably from 0.1 to 10 wt. -%, particularly preferably from 1 to 6% of the mass. of hydrogen peroxide (calculated as 100%H2O2).

Taking into account listed to this point, a preferred form of execution of the invention, the special and clearly the preferred form of execution of the invention is that the means for lightening keratin fibers a cosmetic medium contains as a first component at least one compound selected from the group which consists of:

4-acetyl-1-methylpyridine-l-toluensulfonate, 4-acetyl-1-methylprednisolone, 4-acetyl-1-methylpyridinium, 4-acetyl-1-methylenetetrahydrofolate, 4-acetyl-1-arylpyrimidine-l-toluensulfonate, 4-acetyl-1-allylisothiocyanate, 4-acetyl-1-arylpyrimidine, 4-acetyl-1-allylpyrocatechol, 4-acetyl-1-(2-hydroxyethyl)pyridine-p-toluensulfonate, 4-acetyl-1-(2-hydroxyethyl)pyridinemethanol, 4-acetyl-1-(2-hydroxyethyl)pyridineboronic, as well as 4-acetyl-1-(2-hydroxyethyl)pyridinedicarboxylate;

the second component is an additional activator bleaching steps, at least one compound selected from the group comprising glycine, benzyl alcohol and sodium coquette-30 self is t, and as a third component contains hydrogen peroxide in the already described preferred quantities.

And, finally, in the highest degree preferred are the tools that contain one of the following combinations, in which data in mass quantities, in turn, relate to the overall weight of the tool, ready for use:

The combination of (a):

from 0.1 to 4.0% mass-acetyl-1-methylpyridinium-p-toluensulfonate, from 0.1 to 3.0 wt%. glycine and 0.1 to 12.0 wt%. peroxide of hydrogen.

The combination of (b):

from 0.1 to 4.0% mass-acetyl-1-methylpyridinium-p-toluensulfonate, from 0.1 to 3.0 wt%. benzyl alcohol and 0.1 to 12.0 wt%. peroxide of hydrogen.

Combination (s):

from 0.1 to 4.0% mass-acetyl-1-methylpyridinium-p-toluensulfonate, from 0.1 to 3.0 wt%. sodium coquette-30 sulfate (the active substance) and 0.1 to 12.0 wt%. peroxide of hydrogen.

The processes of bleaching on the keratin fibers occur usually in an alkaline environment. However, in order to preserve the keratin fibers, and the skin for a longer time, it is undesirable setting too high a pH. Therefore, it is preferable, when the pH of tools, ready to use, is between 7 and 11, in particular between 8 and 10.5. The pH within this invention are the quantities of pH, which was measured is the temperature of 22°C. Alkalizing agents that can be used according to the invention for regulating the preferred pH level can be chosen from the group which consists of ammonia, hydroxides of alkali metals, alkanolamine, metasilicate alkali metal phosphates, alkali metal and hydrogen phosphates of alkali metals. As ions of alkali metals are preferably lithium, sodium, potassium, especially sodium or potassium. Hydroxides of alkali metals, which can be used as alkalizing agents according to the invention, preferably selected from the group comprising sodium hydroxide and potassium hydroxide.

Alkanolamine that can be used as alkalizing agents according to the invention, preferably selected from primary amines with a primary alkyl frame with the number of carbon atoms from 2 to 6, which contains at least one hydroxyl group. Particularly preferred alkanolamine chosen from the group comprising 2-aminoethan-1-ol (monoethanolamine), 3-aminopropan-1-ol, 4-aminobutane-1-ol, 5-aminoindan-1-ol, 1-aminopropan-2-ol, 1-aminobutane-2-ol, 1-aminoindan-2-ol, 1-aminoindan-3-ol, 1-aminoindan-4-ol, 3-amino-2-methylpropan-1-ol, 1-amino-2-methylpropan-2-ol, 3-aminopropane-1,2-diol, 2-amino-2-methylpropan-1,3-diol. According to the invention is highly preferred alkanolamines are selected from the group includes 2-aminoethan-1-ol, 2-amino-2-methylpropan-1-ol, and 2-amino-2-methylpropan-1,3-diol.

For intensive lightening strongly dark hair exclusive use of hydrogen peroxide or its products attach to organic or inorganic compounds is often insufficient. In these cases, as a rule, uses a combination of hydrogen peroxide and persulfates or peroxodisulfate. It turned out that adding the derivatives azulfidine General structure (I) according to the invention, as well as toxicologically safe extra brightening activator actions, not only in the case of one hydrogen peroxide, but in the case of the combination of hydrogen peroxide with salts of persulfates or salts peroxodisulfate, the result is increased brightening abilities.

Therefore, in another embodiment of the invention, provided that the consumer feels the need for very intensive blendirovanie, it may be preferable, if in addition to the cationic derivative of azulfidine General structure (I), toxicologically safe extra brightening activator actions, as well as hydrogen peroxide, means for lightening keratin fibers additionally contains at least one inorganic with the ü of persulfate or salt peroxodisulfate.

Preferred salts of peroxodisulfate are peroxodisulfate ammonium, peroxodisulfate potassium and peroxodisulfate sodium. These peroxodisulfate salt may be contained in an amount of from 0.1 to 25 wt. -%, in particular, in amounts of from 0.5 to 15 wt. -%, in terms of the total weight of tools, ready to use.

As already mentioned, the means according to the invention immediately before use can be made of two or more separately packaged compositions. In particular, it is proposed to separate the combined ingredients to prevent premature reaction.

Therefore, the usual way is that the first tool that contains at least one cationic derivative of azulfidine General Formula (I) and at least one toxicologically safe extra brightening activator actions, immediately before use is mixed with a second agent which contains one or more oxidizing agents according to the invention.

Thus, another object of this invention is a means for lightening keratin fibers, especially human hair, which is obtained immediately before applying to the hair of the fluid composition which contains a cationic derivative of azulfidine total f is rmula (I), and toxicologically safe extra brightening activator action, and an oxidizing composition containing at least one oxidant selected from the group comprising hydrogen peroxide and/or products of its accession to organic or inorganic compounds.

The oxidizing composition is preferably an aqueous, fluid oxidizing composition. While the preferred means according to the invention for lightening keratin fibers are distinguished by the fact that this fluid oxidizing composition, in terms of its mass contains from 40 to 90 wt. -%, preferably from 50 to 85 wt. -%, particularly preferably from 55 to 80 wt. -%, more preferably from 60 to 77.5% of the mass. and, above all, from 65 to 75% of the mass. water.

The use of salts of persulfates or salts peroxodisulfate, as a rule, is carried out in the form of dust-free powder or in the form of compressed molded particles. To prevent premature decomposition of the derivatives azulfidine according to the invention in contact with the salts of persulfate or peroxodisulfate, according to the invention is preferable to provide persulfates or respectively peroxodisulfate in the form of separately packaged component C.

In this regard, the means for lightening human the hair, consisting of 3 components, is another subject of this invention. This tool is obtained immediately before applying to the hair by thoroughly mixing a fluid composition which contains a cationic derivative of azulfidine General Formula (I), as well as toxicologically safe extra brightening activator actions oxidizing composition containing at least one oxidant selected from the group comprising hydrogen peroxide and/or products of its accession to organic or inorganic compounds, and optionally a third, which is in the form of a powder composition C, which contains at least one inorganic salt of persulfate or peroxodisulfate.

The mixing of compositions A and B, or respectively optionally, compositions A, B and C before use results in ready-to-use mixture, which is a means according to the invention with three mandatory ingredients.

It is preferable to fluid compositions A and/or B is added to the emulsifier or surfactant, and a surfactant, depending on the directions of use are referred to as surfactants or emulsifiers are selected from anionic, cationic, Zvi the Ter-ion, amphoteric and nonionic surfactants and emulsifiers. These substances are described in detail next.

As anionic surfactants in the compositions according to the invention are suitable all anionic surfactants suitable for application to the human body. These substances are characterized by imparting solubility in water, anionic groups such as carboxylate, sulphate, sulphonate or phosphate group and a lipophilic alkyl group containing from about 8 to 30 carbon atoms. Additionally, the molecule may contain simple group glycolic or polyglycolic esters, fragments of ester, simple ester and amides and hydroxyl groups. Examples of suitable anionic surfactants are, respectively, in the form of sodium, potassium, ammonium, and mono-, di - and trialkanolamines salts with the number of carbon atoms in alkanones group is from 2 to 4, linear and branched fatty acids (Soaps), ethers, carboxylic acids of the formula RO(CH2CH2O)×CH2COOH, acylcarnitine, acultural, utilizationin, if necessary polyalkoxysiloxanes complex mono - and dialkyl ethers sulfonterol acid, linear alkanesulfonyl, linear α-olefins Ponty, the sulfonates of unsaturated fatty acids, methyl ester of α-califoirnia acids, alkyl sulphates and sulfates simple alilovic ethers of the formula RO(CH2CH2O)×SO3mixtures of surface-active hydroxysulphate, sulfated simple hydroxyalkylated and/or hydroxyethylpyrrolidine esters, esters of tartaric acid and citric acid and alcohols, phosphates simple alilovic and/or simple alkenovich esters, sulfated complex acceleglove the fatty acid esters of the formula RC(O)O(alkO)nSO3H and monoglyceride sulfate and simple monoglyceride ether.

Zwitter-ionic surface active agents are indicated by such surface-active compounds which contain in the molecule at least one Quaternary ammonium group and at least one carboxylate, sulphonate or sulphate group. Especially suitable zwitter-ionic surface-active substances are the so-called betaines, such as glycine chelates of N-alkyl-N, N-dimethylammonio, for example, cocoalkylamine, N-acylaminoacyl-N, N-dimethylaminopyridine, for example, chocolatechipoatmealcookierec, and 2-alkyl-3-carboxymethyl-3-hydroxymethylimidazole, respectively, containing from 8 to 18 carbon atoms in the al is safe or acyl groups, and chocolateeruptioncheesecakerecipe.tenpuffed.in zwitter-ionic surface-active substance is known amide derivative of fatty acid cocamidopropylbetaine, according to the designation in the INCI nomenclature.

Under amphoteric surfactants understand such surface-active compounds which, apart from alkyl or acyl group having from 8 to 24 carbon atoms, contain in the molecule at least one free amino group and at least one-COOH - or SOH-group and capable of forming internal salts. Examples of suitable amphoteric surfactants are N-allylglycine, N-alkylphosphonate acid, N-acylaminoalkyl acid, N-alkylenediamine acid, N-hydroxyethyl-N-alkylamidoamines, N-alkyltin, N-acylcarnitine, 2-alkylenediamine acid and alkylaminocarbonyl acid containing from about 8 to 24 carbon atoms in the alkyl groups.

Particularly preferred amphoteric surfactants are N-cocoalkylamine, chocolateeeeeeeeeeeeeee and azilsartan with the number of carbon atoms from 12 to 18.

In addition, appeared to be preferred, if the illuminating means according to the invention contain seionage the major surfactants. Nonionic surfactants as the hydrophilic group include, for example, paleologou group, a group of simple polyalkyleneglycol ether, or a combination of paleologou and simple polyglycolether groups. Such compounds are, for example,

- addition products of 2 to 50 mol of ethylene oxide and/or 0 to 5 mol propylene oxide to linear or branched fatty alcohols with a number of carbon atoms from 8 to 30, to fatty acids with the number of carbon atoms from 8 to 30, and alkyl phenols with the number of carbon atoms in the alkyl of 8 to 15,

- having metal end or alkyl with the number of carbon atoms from 2 to 6 group, the addition products of 2 to 50 mol of ethylene oxide and/or 0 to 5 mol propylene oxide to linear or branched fatty alcohols with a number of carbon atoms from 8 to 30, to fatty acids with the number of carbon atoms from 8 to 30, and alkyl phenols with the number of carbon atoms in the alkyl of 8 to 15,

- complex mono - and diesters of fatty acids with the number of carbon atoms from 12 to 30 products and joining from 1 to 30 mol of ethylene oxide to glycerin,

- complex polyglyceryl esters and alkoxysilanes complex polyglyceryl ethers,

- addition products of 5 to 60 mol of ethylene oxide to castor oil and otverzhdennom castor oil,

- esters of polyols and fatty to the slot,

- alkoxysilane, preferably propoxycarbonyl and, in particular, ethoxylated mono-, di - and triglycerides, such as, for example, glycerylmonostearate +20 ethylene oxide and glycerylmonostearate +20 ethylene oxide,

- alkoxysilane complex alkalemia the fatty acid esters of the formula RC(O)-(OCH2CH2)wOR', in which RC(O)- represents a linear or branched, saturated and/or unsaturated acyl residue with the number of carbon atoms from 6 to 22, R' is a linear or branched alkyl residue with the number of carbon atoms from 1 to 4, and w is a number from 1 to 20,

- aminoxide,

- mixed simple hydroxyether,

- esters of sorbitan and fatty acids and addition products of ethylene oxide to complex sorbitolovy esters of fatty acids, such as, for example, Polysorbate, sorbitanoleat and sorbitanoleat +20 mol of ethylene oxide (EO),

- esters of sugars and of fatty acids and addition products of ethylene oxide to esters of sugars and of fatty acids,

- addition products of ethylene oxide to alkanolamide fatty acids and fatty amines,

- N-Alkylglucoside fatty acids,

- ALKYLPHENOLS and alkylphenolethoxylates containing an alkyl chain of from 6 to 21 carbon atoms, especially from 6 to 15 carbon atoms and from 0 to 30 ethylenoxide and/or propylenoxide structural units. Preferred representatives of this class are, for example, Nonylphenol +4 EO, Nonylphenol +9 EO, op +3 EO and op +8 EO,

- alkylpolyglycoside corresponding to the General formula RO-(Z)xand R represents alkyl, Z is a sugar, and x is equal to the number of structural units of the sugar. Alkylpolyglycoside, which can be used according to the invention may contain only one specific alkyl residue.

As nonionic surfactants are suitable, in particular, alkylene - and-oligoglycosides with the number of carbon atoms in the alkyl of 8 to 22, and their ethoxylated analogs. First of all, proved to be particularly suitable methoxylamine connection.

These compounds are distinguished by the fact that, as a structural element of sugar Z can be any mono - or oligosaccharides. Typically used sugar containing 5 or 6 carbon atoms, and the corresponding oligosaccharides. Such sugars include glucose, fructose, galactose, arabinose, ribose, xylose, lyxose, allose, altrose, mannose, gulose, idose, talose and sucrose. Preferred structural elements of the sugars are glucose, fructose, galactose, arabinose and sucrose; glucose is particularly preferred.

Alkylpolyglycoside that you can use to agree on the but to the invention, on average contain from 1.1 to 5 structural fragments of sugar. Alkylpolyglycoside with value x from 1.1 to 2.0 are preferred. Highly preferred are Alkylglucoside, in which x is from 1.1 to 1.8.

Also according to the invention can be used alkoxysilane homologues listed alkylpolyglycoside. These homologues can contain an average of 10 ethyleneoxide and/or propyleneoxide structural units in each Alkylglucoside structural fragment.

Other preferred nonionic surfactants has been the addition products alkalisation to saturated linear fatty alcohols and fatty acids, respectively, containing from 2 to 30 mol of ethylene oxide to one mol of fatty alcohol or fatty acid. Composition with wonderful characteristics were also obtained, if they are as nonionic surfactants contain esters of fatty acids and ethoxylated glycerin.

It is particularly preferred nonionic surfactants with an easy machinability are substances that are commercially available in pure form as a solid or liquid. Determination of purity in this context refers not to chemically clean the m connections. Moreover, in particular, if we are talking about products based on natural ingredients, can be used mixtures of different homologues, for example, with different length of alkyl chain, such as those obtained in the case of products based on natural fats and oils. Also in the case alkoxysilane products are usually mixtures with varying degrees of alkoxysilane. On the contrary, the concept of purity in this context refers to the fact that the selected substance preferably should not contain solvents, thickeners and other impurities.

In the case of surface-active substances, which represent addition products of ethylene and/or propylene oxide to fatty alcohols or derivatives of these accession, can be used as products with a "normal" distribution of homologues, and products with a narrow distribution of homologues. Under "normal" distribution of homologues understand the mixture of homologues, which is obtained by the interaction of fatty alcohol and accelerated with the use as catalysts of alkali metals, hydroxides of alkali metals or alkali metal alcoholate. The narrow distribution of homologues, on the contrary, are obtained when the catalysts are used, for example, hydrotalcite, salts of alkaline earth metals and simple esters of carboxylic to the slot, oxides, hydroxides or alkaline earth metal alcoholate. The application of products with a narrow distribution of homologues may be preferable.

Anionic, nonionic, zwitter-ionic or amphoteric surfactants are used in quantities of from 0.1 to 45 wt. -%, preferably from 1 to 30 wt%. and most preferably from 1 to 15 wt. -%, in terms of the total number of tools, ready to use.

According to the invention is also preferred are cationic surfactants, related to the type of Quaternary ammonium compounds, exterkate and amidoamine. Preferred Quaternary ammonium compounds are ammonium halides, especially the chlorides and bromides, such as the chlorides of alkyltrimethylammonium, chlorides of dialkyldimethylammonium and chlorides of trialkylamine, for example, cetyltrimethylammoniumbromide, steartrimonium, distearyldimethylammonium, lauryldimethylamine, lauryldimethylamine and triethylmethylammonium and connection imidazole, known under the designations in the INCI nomenclature as quaternium-27 and quaternium-83. The long alkyl chains of the above surfactants preferably contain from 10 to 18 carbon atoms. Other cationic surfactants the substances, which can be used according to the invention, are quaternion protein hydrolysates.

Alkylamidoamines usually obtained by amidation of natural or synthetic fatty acids and fragments of fatty acids dialkylaminoalkyl and in addition to a good conditioning action is particularly notable for their good biological degradability.

Also very good Biodegradability have ester compounds, so-called "exterkate". Exterkate are known substances which as structural elements contain at least one ester function and at least one Quaternary ammonium group. The preferred exterkate are Quaternary ester salts of fatty acids with triethanolamine, quaternion ester salts of fatty acids with diethanolamine and quaternion ester salts of fatty acids with 1,2-dihydroxyphenylalanine.

Cationic surfactants are contained in the means used according to the invention, preferably in quantities from 0.05 to 10 wt. -%, in terms of the whole tool. Especially preferred are amounts from 0.1 to 5 wt. -%

In a preferred embodiment of the invention is t to be the preferred nonionic, zwitter-ionic and/or amphoteric surfactants, and mixtures thereof.

In another preferred embodiment of the invention the action of the active substances according to the invention can be amplified using emulsifiers. Such emulsifiers are, for example:

- addition products of 4 to 30 mol of ethylene oxide and/or 0 to 5 mol propylene oxide to linear fatty alcohols with a number of carbon atoms from 8 to 22, to fatty acids with the number of carbon atoms from 12 to 22, and to alkyl phenols with the number of carbon atoms in the alkyl group is from 8 to 15,

- complex mono - and diesters of fatty acids with the number of carbon atoms from 12 to 22 and products joining from 1 to 30 mol of ethylene oxide to the polyol with the number of carbon atoms from 3 to 6, first of all, glycerin,

- ethylenoxide and polyglycerins products join esters of methylglucoside and fatty acids, alkanolamides fatty acids and glutamicum fatty acids,

- alkylene - and-oligoglycosides with the number of carbon atoms in the alkyl of 8 to 22, and their ethoxylated analogs, and preferred is a degree of oligomerization ranging from 1.1 to 5, especially from 1.2 to 2.0, and glucose as the sugar component,

- mixtures of alkyl(oligo)glucosides and fatty alcohols,

- addition products of 5 to 60 mol of ethylene oxide to castor mA is Lou and otverzhdennom castor-oil,

partial esters of polyols containing 3 to 6 carbon atoms, and saturated fatty acids with the number of carbon atoms from 8 to 22,

- sterols, in particular tosterone (cholesterol and lanosterol, phytosterols (ergosterol, stigmasterol and sitosterol)and mycostatin,

phospholipids, such as lecithin or phosphatidylcholine,

- esters of fatty acids and sugars and sugar alcohols such as sorbitol,

- polyglycine and derivatives of polyglycerol, such as, for example, polyglyceryl-12-hydroxystearate,

linear and branched fatty acids with the number of carbon atoms from 8 to 30, and their sodium (Na), potassium (K), ammonium, calcium (CA-), magnesium (Mg) and zinc (Zn) salt.

The means according to the invention preferably contain the emulsifiers in amounts of from 0.1 to 25 wt. -%, first of all, from 0.5 to 15 wt. -%, in terms of the total number of tools, ready to use.

Preferably the compositions according to the invention can contain at least one nonionic emulsifier with an index value products HLB (hydrophilic-lipophilic balance) of from 8 to 18, in accordance with the definition provided in the publication Rompp-Lexikon Chemie (Hrg. J. Falbe, M. Regitz), 10. Edition, Georg Thieme Verlag Stuttgart, New York, (1997), page 1764. Nonionic emulsifiers with an index products HLB constituting 10-15, according to izaberete the Oia can be particularly preferred.

Among these types of particularly preferred emulsifiers may be emulsifiers that do not contain in the molecule with ethylene oxide and/or propylene oxide.

The means according to the invention can additionally also contain dyes and/or intermediates for dyes, and, therefore, be supplied as tools that simultaneously possess and lightening and coloring effects. Such means hereinafter referred to as "painting tools"as "brightening coloring tools" or "coloring and bleaching means."

Oxidative dyeing of fibers may occur in the presence of intermediates for oxidative dyes mainly under the action of atmospheric oxygen. However, preferably used chemical oxidizing agent, particularly when in addition to the dyeing of human hair the desired bleaching effect. This brightening effect may be desirable regardless of the method of staining. As oxidant consider persulfates, chlorites and, above all, hydrogen peroxide or products of its accession to urea, melamine and sodium borate.

However, according to the invention the means for oxidative dyeing can also be applied to the hair together with a catalyst that activates okelani the intermediate product for the coloring matter, for example, oxygen. Such catalysts are, for example, certain enzymes, iodides, quinones or metal ions.

Suitable enzymes are, for example, horseradish peroxidase, which can greatly exacerbate the effects of small amounts of hydrogen peroxide. In addition, according to the invention are suitable such enzymes that use oxygen directly oxidize the intermediate product for the oxidative coloring agents such as, for example, laccase, or emit small amounts of hydrogen peroxide in situ and in this way activate the biocatalytic oxidation of the intermediate product for the coloring matter. Particularly suitable catalysts for the oxidation of the dye precursors of substances are the so-called two-electron oxidoreductase in combination with specific for their substrates, pyranose oxidase (for example, D-glucose or galactose), glucose oxidase (D-glucose), oxidase glycerol (glycerine), pyruvate oxidase (benzovodorodnoj acid or its salts), alcoholecstasy (with alcohol, such as Meon, EtOH), lactatemia (lactic acid), tyrosinase (tyrosine), uricase (uric acid), cholinesterase (choline), and also oxidase amino acids (amino acids).

When using additional the CSOs oxidizing agent appropriate, if the lightening and/or coloring agent immediately before use is prepared by mixing the composition with additional oxysomes agent with a solution of hydrogen peroxide according to the invention and the composition containing the compounds of Formula (I) and toxicologically safe extra brightening activator action, and if necessary intermediate products for the coloring matter. The resulting ready-to-use product for lightening and/or dyeing of the hair should preferably have a pH in the range from 6 to 12. Particularly preferably used for lightening and/or dyeing hair in a weakly alkaline region. The temperature can be between 15 and 40°C. After a reaction time of from 5 to 45 minutes a means for coloring the hair is removed by rinsing from the hair that had to be painted. Subsequent washing with shampoo excluded if you have used a medium containing an effective surfactant, for example, coloring shampoo.

In the case of hair, heavily exposed to staining, the tool according to the invention can, in particular, if necessary, be applied to the hair with additional intermediate products for coloring substances which, and without pre-mixing with oxidizing components. Then, after an exposure time of 20 to 30 minutes, optionally after intermediate rinsing, apply oxidizing component is mixed with a composition comprising a cationic derivative of azulfidine corresponding to the Formula (I), and toxicologically safe extra brightening activator action. After an additional reaction time of from 10 to 20 minutes, rinse and optionally another wash with shampoo. In the case of this variant of the invention in accordance with the first variant, in which the prior application of an intermediate product for the coloring matter should contribute to a better penetration into the hair, for the respective funds establish a pH from about 4 to 7. According to the second variant first achieve oxidation in air, which caused the tool preferably has a pH of from 7 to 10. Subsequent accelerated oxidation may be preferred for further use as oxidizing agents solutions peroxodisulfate, acidic.

The use of certain ions or metal complexes may also be preferred in order to achieve intense staining. Suitable ions of the metals are for example, Zn2+, Cu2+, Fe2+, Fe3, Mn2+, Mn4+Li+, Mg2+Ca2+Ce2+, V3+, Co2+, EN3+and Al3+. Especially suitable are Zn2+, Cu2+and Mn2+. In principle, these metal ions can be used in the form of any physiologically acceptable salts or in the form of complex compounds. Preferred salts are acetates, sulfates, halides, lactates and tartratami. By using these metal salts can accelerate the formation of coloring and purposefully influence the colors.

Especially preferred products contain from 0.0001 to 2.5 wt. -%, preferably from 0.001 to 1% of the mass. at least one compound from the following group: copper chloride (CuCl2), copper sulfate (CuSO4)sulphate iron (II)sulfate, manganese (II)chloride manganese (II)chloride cobalt (II), cerium sulfate, cerium chloride, sulfate, vanadium, manganese oxide (MnO2).

According to the invention, also preferred is the use of so-called complexing agents. The complexing agents are substances that can form complexes with metal ions. Preferred complexing agents are the so-called chelate complexing Agents, i.e. substances that form ions met low cyclic compounds, moreover, a separate ligand has more than one coordination compounds with a Central atom, that is, at least "two". Thus, in this case, the connection, which is usually linear, with the help of complexation are closed in a ring via a single ion. The number of bound ligands depends on the coordination number of the Central ion.

In the framework of the present invention may be used, the complexing Agents of the issues of the prior art. They may belong to different chemical classes. Preferably in individual form or in mixture with each other are used:

polycarboxylic acid, for which the sum of the number of carboxyl and optionally hydroxyl groups is at least 5, such as gluconic acid,

nitrogen-containing mono - or polycarboxylic acids, such ethylenediaminetetraacetic acid (EDTA), N-hydroxyethylenediaminetriacetate acid, diethylenetriaminepentaacetic acid, gidroksietilirovanny acid, nitrilotriacetate acid-3-propionic acid, seeingufospa acid, N,N-di(2-hydroxyethyl)glycine, N-(1,2-dicarboxy-2-hydroxyethyl)glycine, N-(1,2-dicarboxy-2-hydroxyethyl)aspartic acid or nitrilotriacetic acid (NTA),

genialny diphosphonic acids, such as 1-hydroxyethane-1,1-DeVos is about acid (HEDP), its higher homologues containing up to 8 carbon atoms, and derivatives of these compounds containing hydroxy or amino groups and 1-aminoethane-1,1-diphosphonic acid, its higher homologues containing up to 8 carbon atoms, and derivatives of these compounds containing hydroxy or amino groups,

aminophosphonate acid, such as ethylenediaminetetra(methylenephosphonate acid), diethylenetriaminepenta(methylenephosphonate acid) or nitrilotri(methylenephosphonate acid),

phosphomolybdate acid, such as 2-phosphonobutane-1,2,4-tricarboxylic acid, as well as

cyclodextrins.

The complexing agents preferred according to the invention are phosphonates, preferably hydroxyalkyl or aminoalkylphosphonic and, above all, 1-hydroxyethane-1,1-diphosphonate (HEDP), or di - or TETRANITRATE salt and/or ethylenediaminetetramethylene (EDTMP) or respectively its hexanetriol salt and/or diethylenetriaminepentaacetate (DTPMP) or hepta - or octonaria salt.

As already mentioned, the means according to the invention can be provided not only as a pure brightening means, that is, the so-called blunderous tools, but also as a coloring and lightening means that simultaneously with the clarification also contribute to the staining ke is hatinovich fibers.

To provide a cosmetic change color, in particular, to the skin or fibers containing keratin, such as, for example, human hair, specialist, depending on the requirements for staining various known coloring system.

For permanent, intense staining with the appropriate strength characteristics apply so-called oxidative coloring tools. Such coloring tools usually contain intermediates for oxidative dyes, so-called manifest components and coupler components. Showing the components under the action of an oxidant or oxygen, with each other or by joining with one or more coupler components form the actual coloring substance. Thus oxidizing dyes differ wonderful, lingering long colour. However, to obtain a natural result when painting usually have to apply a mixture of a large number of intermediate products for oxidizing dyes, in addition, in many cases, to obtain shades apply direct dyes.

For the temporary dyeing are usually used coloring or tinting means that the coloring components sod is rat so-called direct dyes. In this case we are talking about the coloring matter molecules directly adsorbed on the substrate and do not require oxidation process for the formation of color. These dyes include, for example, henna, known since ancient times for dyeing hair and body. These dyes are usually significantly less resistant to washing with shampoo than oxidative dyes, so after this comes much faster in many cases undesirable change colors or obvious uniform loss of color.

And finally, much attention was paid another way of colouring. In this method, the substrate, for example, hair, applied predecessors natural hair coloring substance melanin, then within the oxidation process in the hair they form analogues of natural dyes. In the case of primarily multiple, applications, products containing 5,6-dihydroxyindoline, perhaps people with graying hair to give a natural hair color. Education coloring may occur involving oxygen as the sole oxidant, so there is no need to resort to other oxidizing agents. For people with the original hair color from blond to brown as the only predshestvennikami can be indolin. For use by people with natural red hair and, above all, with hair from dark to black color, on the contrary, satisfactory results are often achieved only by joint application of additional dye components, in particular, certain intermediates for oxidative dyes.

In the embodiment of the invention in terms of color change the subject of this invention can be combined with at least one component that changes color. Changing the color of the components within the scope of this invention preferably are selected:

(1) at least one intermediate product of the oxidation dye

and/or

(2) at least one direct dye.

With this purpose, such means according to the invention contain at least one intermediate product for the dye, preferably an intermediate product of the oxidation dye and/or at least one direct dye. Among these substances are primarily preferred the so-called oxidative coloring agents.

Oxidative coloring agents according to the invention contain at least one coupler and at least one component exhibiting. Coupler and showing components are also referred to as intermediate the products for oxidative coloring tools. Moreover, the oxidative coloring means according to the invention as a means for imparting shades may also contain direct dyes.

Therefore, the preferred means for dyeing and/or lightening keratin fibers according to the invention are characterized in that they contain at least one intermediate product of the oxidation dye showing the type and/or coupler type.

Preferred showing components are selected from at least one of the compounds of the group which is formed from p-phenylenediamine, p-toluylenediamine, 2-(2-hydroxyethyl)-p-phenylenediamine, 2-(1,2-dihydroxyethyl)-p-phenylenediamine, N,N-bis(2-hydroxyethyl)-p-phenylenediamine, N-(4-amino-3-were)-N-[3-(1H-imidazol-1-yl)propyl]amine, N,N'-bis(2-hydroxyethyl)-N,N'-bis(4-AMINOPHENYL)-1,3-diaminopropan-2-ol, bis(2-hydroxy-5-AMINOPHENYL)methane, 1,3-bis(2,5-diaminophenoxy)propan-2-ol, N,N'-bis(4-AMINOPHENYL)-1,4-disallocation, 1,10-bis(2,5-diaminophenyl)-1,4,7,10-tetraoxygen, p-aminophenol, 4-amino-3-METHYLPHENOL, 4-amino-2-aminomethylphenol, 4-amino-2-(1,2-dihydroxyethyl)phenol and 4-amino-2-(diethylaminomethyl)phenol, 4,5-diamino-1-(2-hydroxyethyl)pyrazole, 2,4,5,6-tetraaminopyrimidine, 4-hydroxy-2,5,6-triaminopyrimidine, 2-hydroxy-4,5,6-triaminopyrimidine, as well as physiologically acceptable salts of these compounds.

color-forming components within the oxidation dyeing of themselves do not form significant staining, and always require the presence manifesting components. Therefore, according to the invention is preferred to use at least one component exhibiting additionally used at least one coupler component.

Especially preferred coupler components are selected from the following series: m-aminophenol, 6-amino-2-METHYLPHENOL, 3-amino-2-chloro-6-METHYLPHENOL, 2-hydroxy-4-aminophenoxyethanol, 5-amino-4-chloro-2-METHYLPHENOL, 5-(2-hydroxyethyl)amino-2-METHYLPHENOL, 2,4-dichloro-3-aminophenol, 2-aminophenol, 3-phenylenediamine, 2-(2,4-diaminophenoxy)ethanol, 1,3-bis(2,4-diaminophenoxy)propane, 1-methoxy-2-amino-4-(2-hydroxyethylamino)benzene, 1,3-bis(2,4-diaminophenyl)propane, 2,6-bis(2'-hydroxyethylamino)-1-methylbenzol, 2-({3-[(2-hydroxyethyl)amino]-4-methoxy-5-were}amino)ethanol, 2-({3-[(2-hydroxyethyl)amino]-2-methoxy-5-were}amino)ethanol, 2-({3-[(2-hydroxyethyl)amino]-4,5-dimetilfenil}amino)ethanol, 2-[3-morpholine-4-ylphenyl)amino]ethanol, 3-amino-4-(2-methoxyethoxy)-5-methylphenylamine, 1-amino-3-bis-(2-hydroxyethyl)aminobenzene, resorcinol, 2-methylresorcinol, 4-chlororesorcinol, 1,2,4-trihydroxybenzene, 2-amino-3-hydroxypyridine, 3-amino-2-methylamino-6-methoxypyridine, 2,6-dihydroxy-3,4-dimethylpyridine, 3,5-diamino-2,6-dimethoxypyridine, 1-phenyl-3-methylpyrazole-5-Oh, 1-naphthol, 1,5-dihydroxynaphthalene, 2,7-dihydroxynaphthalene, 1,7-dihydro shall synaptein, 1,8-dihydroxynaphthalene, 4-hydroxyindole, 6-hydroxyindole, 7-hydroxyindole, 4-hydroxyindole, 6-hydroxyindole, 7 hydroxyindole, or mixtures of these compounds or physiologically acceptable salts of the above compounds.

Manifesting or color-forming components are preferably used respectively in amounts of 0.005 to 20 wt. -%, preferably from 0.1 to 5 wt. -%, accordingly, in terms of oxidative coloring agent, ready to use.

While showing components and coupler components are generally used in approximately equivalent molar ratio to each other. Also if using equivalent molar ratio was expedient, a certain excess of individual intermediate product for auxiliaries coloring tools is not harmful, so showing components and coupler components may be present in a molar ratio of from 1:0.5 to 1:3, especially from 1:1 to 1:2.

In addition, the means according to the invention can contain at least one direct dye. When it comes to coloring substances that are directly adsorbed on the hair and do not require oxidation process for the formation of color. Direct dyes are usually nitrophenylacetylene, nitrolingual, isocratic and, anthraquinones Il Indianola.

Direct dyes, respectively, are preferably used in quantities of from 0.001 to 20 wt. -%, in terms of all the composition is ready for use. Preferably the total number of direct dye is not more than 20% of the mass.

Direct dyes can be divided into anionic, cationic and nonionic direct dyes. Preferred anionic direct dyes are the compounds known under the international names or trade names dye acid yellow Acid Yellow 1, dye Yellow 10, acid yellow Acid Yellow 23, acid yellow Acid Yellow 36, acid orange, Acid Orange 7, acid red Acid Red 33, acid red Acid Red 52, pigment red Pigment Red 57:1, the dye acid blue Acid Blue 7, acid green, Acid Green 50, acid violet, Acid Violet 43, acid black Acid Black 1, and the dye acid black Acid Black 52. In this preferred cationic direct dyes are cationic triphenylmethane dyes, such as, for example, a cationic dye blue Basic Blue 7, cationic blue Basic Blue 26, cationic violet Basic Violet 2 and cationic violet Basic Violet 14; aromatic systems which are substituted Quaternary nitrogen-containing group, such as, for example, a cationic dye yellow Basic Yellow 57, cationic red Basic Red 76, cationic blue Bsic Blue 99, the cationic dyes brown Basic Brown 16 and Basic Brown 17, as well as direct dyes, which include a heterocycle containing at least one Quaternary nitrogen atom, for example, as those that are listed in European patent application EP-A2-998 908 in claims 6 to 11, referenced explicitly. Compounds that are also known under the designations of the cationic dye yellow Basic Yellow 87, cationic orange Basic Orange 31 and cationic red Basic Red 51, are highly preferred cationic direct dyes. Cationic direct dyes, which are supplied in the market under the trademark Arianor®, according to the invention are also highly preferred cationic direct dyes. As nonionic direct dyes are suitable, in particular, non-ionic nitro -, and quinone dyes and neutral azo dyes. Preferred nonionic direct dyes are the compounds known under the international names or trade names of the national Assembly Yellow 2, HC Yellow 4, HC Yellow 5, HC Yellow 6, HC Yellow 12, HC Orange 1, disperse orange, Disperse Orange 3, HC Red 1, HC Red 3, HC Red 10, HC Red 11, HC Red 13, HC Red BN, HC Blue 2, HC Blue 11, HC Blue 12, disperse blue, Disperse Blue 3, HC Violet 1, disperse violet Disperse Violet 1, Disperse Violet 4, disperse black Disperse Black 9, as well as 1,4-diamino-2-nitrobenzene, 2-and the Ino-4-NITROPHENOL, 1,4-bis(2-hydroxyethyl)amino-2-nitrobenzene, 3-nitro-4-(2-hydroxyethyl)aminophenol, 2-(2-hydroxyethyl)amino-4,6-dinitrophenol, 4-[(2-hydroxyethyl)amino]-3-nitro-1-methylbenzol, 1-amino-4-(2-hydroxyethyl)amino-5-chloro-2-nitrobenzene, 4-amino-3-NITROPHENOL, 1-(2'-areideal)amino-4-nitrobenzene, 2-[(4-amino-2-nitrophenyl)amino]benzoic acid, 6-nitro-1,2,3,4-tetrahydroquinoxaline, 2-hydroxy-1,4-Naftokhimik, picramic acid and its salts, 2-amino-6-chloro-4-NITROPHENOL, 4-ethylamino-3-nitrobenzoic acid, and 2-chloro-6-ethylamino-4-NITROPHENOL.

It is not necessary that these direct dyes represented, respectively, of individual compounds. Moreover, if this is due to the method of obtaining a separate dye, smaller amounts can still contain other components, to the extent they do not adversely impact on the result of staining or should not be excluded on other grounds, for example, poison.

In addition, as direct dyes can also be used dyes of natural origin, such as those contained, for example, red henna, colorless henna, black henna, chamomile flowers, wood, sandalwood, black tea, buckthorn bark, sage, wood, sandal wood wood, madder root, tanning extract of betel and root alkanna.

In addition, among the ETS according to the invention can contain other active auxiliary substances and additives, such as non-ionic polymers, cationic polymers, zwitter-ionic and amphoteric polymers, anionic polymers, thickeners, structuring agents, compounds for conditioning hair, protein hydrolysates, perfume oils, dimetridazole and cyclodextrins, active substances that improve the hair structure, defoamers such as silicones, dyes for coloring the funds of the active substance against dandruff, such as piroctone alamin, zinc amadin and climbazol, lighting means, in particular, benzophenone derivatives, cinnamic acid and triazine, active substances, such as panthenol, Pantothenic acid, pantolactone, allantoin, pyrrolidinecarbonyl acids and their salts, as well as bisabolol, vitamins, provitamins and vitamin precursor, first of all, these substances from groups A, B3B5B6, C, E, F and H, plant extracts, cholesterol, means affecting the consistency, such as Sugar esters, esters of polyols or simple alkalemia esters of polyols, fats and waxes, such as spermaceti, beeswax, Montan wax and paraffins, alkanolamide fatty acids, substances that contribute to the swelling and penetration substances, giving a matte finish, such as latex, copolymers of styrene/polyvinylpyrrolidone (PVP), stiroh the/acrylamide, tools, giving pearl luster pigments, stabilizers of hydrogen peroxide and other oxidants, displacing agents, such as propane-butane mixture, N2O, dimethyl ether, CO2and the air antioxidants.

The choice of these additional substances is done by a specialist in accordance with the desired properties of the tool.

For other optional components, as well as quantities of these components are strongly advised to pay attention to the well-known specialist guidelines, for example, KP. Schrader, Grundlagen und Rezepturen der Kosmetika, 2nd. Edition, Huthig BuchVerlag, Heidelberg, 1989.

As additional components of the composition according to the invention can contain at least one ammonium compound from the following group: ammonium chloride, ammonium carbonate, ammonium bicarbonate, ammonium sulfate and/or ammonium carbamate in an amount of from 0.5 to 10, preferably from 1 to 5 wt. -%, in terms of the whole composition of this tool.

The means according to the invention contain the active substance in a cosmetic carrier. This cosmetic carrier is preferably water, an alcohol or water-alcohol. For the purpose of lightening the hair such carriers are, for example, creams, emulsions, gels or solutions containing surface-active substances, such as, for example, the Sha is Puni, foaming aerosol or other compositions which are suitable for use on the hair. But it is also possible to store to provide powdered or tableted composition, which is preferred for bleaching products. In this case, before the application of them is preparing the mixture with a solvent such as water or organic solvent, or with a mixture of water and an organic solvent to obtain a mixture, ready for use.

According to the invention the aqueous medium contains at least 40 wt. -%, first of all, at least 50 wt%. water.

Under water-alcohol medium in the framework of this invention it should be understood containing water composition, comprising from 3 to 70% of the mass. alcohol with the number of carbon atoms from 1 to 4, first of all, ethanol or isopropanol. The means according to the invention can additionally contain other organic solvents, such as, for example, methoxybutanol, ethyldiglycol, 1,2-propylene glycol, n-propanol, n-butanol, m-butyleneglycol, glycerin, simple monotropy ether dietilen glycol, and also a simple mono-n-butyl ether of diethylene glycol. While preferred are water-soluble organic solvents.

The preferred means according to the invention are characterized in that they add is Ino contain one non-aqueous solvent, especially preferred means according to the invention contain the solvent in a concentration of from 0.1 to 30 wt. -%, preferably in a concentration of from 1 to 20 wt. -%, highly preferably in a concentration of from 2 to 10 wt. -%, accordingly, in terms of the tool.

The second object of the present invention is a method for lightening keratin fibers, especially human hair, characterized in that the tool corresponding to the first object of the present invention, applied to fibers containing keratin, leave these fibers for a time from 5 to 60 minutes, and then wash or wash out with shampoo. In particular, the temperature during exposure time from 5 to 60 minutes is between 10°C and 40°C, especially between 20°C and 38°C.

Under this method may be preferable that this method is distinguished by the fact that:

if desired, the fiber is applied to the means for pre-processing M1, then

the fibers used means M2, and optionally, before using the tool M2 add another tool M3, this means M2, over time, from 5 to 60 minutes, wash off with these fibers, and after processing, if necessary, to these fibers is applied to the means for processing the M4 and washed off again after a time of exposure, comprising n is how many minutes

at least one of the means M1, M2 or M3, or a mixture of means M2 and M3 represents a tool according to the invention corresponding to the first subject of this invention.

Thus, the means according to the invention can be prepared and appropriately used in the form of one-component tools (coloring and/or lightening means M2) and a two-part money (M2+M3). Separation of multi-component system serves primarily where it is possible to expect or to fear incompatibility of ingredients. In the case of such systems is a tool that should be used is prepared by mixing the components by the user immediately prior to use.

This is the preferred method for dyeing and/or lightening, wherein compounds of General structure (I), as well as additional brightening activator actions first stored separately from the hydrogen peroxide. Thus, another object of the present invention is a method of clarification and, if necessary, dyeing human hair, wherein the composition is water-based, containing hydrogen peroxide, mixed with a composition containing at least one compound of the General structure (I) and at least one toxicologically safe for more and levator brightening action (see above) with the formation means, corresponding to the first object of the present invention, and this tool is applied to the hair.

Another variant of the method according to the invention for clarification and, if necessary, coloring human hair occurs when the composition is water-based, containing hydrogen peroxide, mixed to obtain a homogeneous composition with another tool, preferably containing at least one alkalizing agent and/or a direct dye for the hair and/or at least one intermediate product for oxidative coloring substance, and with the tool containing the compound of the General structure (I) (see above), as well as an additional activator bleaching steps (see above), and this composition is applied to hair.

The third object of this invention is the use of tools associated with the first object of the present invention, for clarification of fibers containing keratin, in particular human hair.

In other preferred embodiments of the method according to the invention or respectively the application according to the invention, the principle of mutatis mutandis ("making sootvetstvujusceje changes"), valid for the means according to the invention.

Examples

1.0 Obtain 1-acetyl-1-methylpyridinium-p-toluensulfonate

For 5 hours in 500 ml of ethanol was boiled under reflux 30.0 g (0.25 mol) of 4-acetylpyridine and 55.8 g (0.30 mol) of a compound methyl ester p-toluenesulfonic acid. The solvent was removed in vacuo using a rotary evaporator, and the residue was extracted by a simple ether. After separation of the ether phase, the product crystallized over time. This product was dried in vacuum. Output: 59,9 g (82.5 per cent);1H-NMR (400 MHz, DMSO-d6): δ [ppm]=and 2.26 (s, 3H); of 2.72 (s, 3H); 3,39 (s, 3H); 7,11 (d, 2H); 7,49 (d, 2H); 8,42 (d, 2H); 9,20 (d, 2H);13C-NMR (400 MHz, DMSO-d6): δ [ppm]=20,8; 26,4; 48,1; 124,8; 125,3; 127,7; 138,9; 145,2; 146,5; 148,3; 195,8.

2. Examples of bleaching

2.1 bleaching with hydrogen peroxide and an additional brightening activator actions

2.1.1 Preparation blinderoaxaca cream

Of the following components as described below were prepared blunderous creams

Source componentwt. -%
V1V2E1E2E3
Hydrenol D6,96,96,96,9 6,9
Lorol techn.2,52,52,52,52,5
Eumulgin B10,60,60,60,60,6
Eumulgin B20,60,60,60,60,6
Akypo Soft 45 NV10,010,010,010,010,0
Plantacare 1200 UP2,02,02,02,02,0
Texapon K 14 S 702,82,82,82,82,8
Ammonium sulfate1,01,01,01,01,0
Axorbin the Wai acid 0,10,10,10,10,1
Natriumsilicat 40/420,50,50,50,50,5
Turpinal SL0,20,20,20,20,2
KOH0,80,80,80,80,8
Ammonia, 25%aqueous solution7,17,17,17,17,1
Glycine--2.0--
Benzyl alcohol : --2,0-
Disponil FES 77 (active substance) ---2,0
4-Acetyl-1-methylpyridine-l-toluensulfonate (according to Example 1.1)2,02,02,02,0
Waterup to 100%up to 100%up to 100%up to 100%up to 100%

Hydrenol® D fatty alcohol with the number of carbon atoms of 16 to 18 (designation item INCI name: Cetearyl alcohol) (company Cognis)

Lorol® tech. fatty alcohol with the number of carbon atoms from 12 to 18 (designation in the INCI nomenclature: (coconut fatty alcohol)) (Cognis)

Eumulgin® B1 ethoxylated (12 EA) fatty alcohol with the number of carbon atoms of 16 to 18 (designation in the INCI nomenclature: (ceteareth-12)) (Cognis)

Eumulgin® B2 ethoxylated (20 EO) fatty alcohol with the number of carbon atoms of 16 to 18 (designation in the INCI nomenclature: (ceteareth-20)) (Cognis)

Akypo® Soft 45 NV sodium salt of a simple ester of acetic acid and fatty alcohol with the number of carbon atoms from 12 to 14 (4,5 EE) (designation item INCI name: sodium Laureth-5-carboxylate) (company KAO Chemicals)

Plantacare® 1200 UP glucoside fatty alcohol with the Islom of carbon atoms from 12 to 16 (designation item INCI name: lauryl glucoside) (company Cognis)

Techarp® K 14 S 70 sodium salt of sulfate of simple miristinovoi ether (about 70% of the active substances; designation item INCI: sodium Miret sulfate) (Cognis)

Turpinal® SL 1-hydroxyethane-1,1-diphosphonic acid (content of active substance of about 60%; the symbol in the INCI nomenclature: heteronomy acid, water) (Solutia)

Natriumsilicat 40/42 sodium liquid glass

Disponil® FES 77 sodium salt of sulfate of a simple ester of a fatty alcohol with the number of carbon atoms from 12 to 18 (30 EA) (about 31-33% active substance in water; designation item INCI: sodium coquette-30 sulfate) (Cognis).

Hydrenol D, Lorol techn., Eumulgin B1, Eumulgin B2, Akypo Soft 45 NV, Plantacare 1200 UP, as well as Techarp K 14 S 70 With melted together at 80°C and was dispersively part of the total water. Then under stirring consistently introduced other components of the formulation. Then added water to 100 wt%. and mixed composition on the cold.

Recipe V1 and V2 are recipes for comparison not relevant to the invention, without additional brightening activator actions recipes from E1 to E3 are examples according to the invention, containing the brightening activator 1-acetyl-1-methylpyridinium-p-toluensulfonate, as well as additional activators brightening action.

2.1.2 Mixing with the dispersion will show what La

Each slanderously cream in a ratio of 1: 1 was mixed with a dispersion of the developer prepared as described below. The pH of the ready mixture for use were between 9 and 10.2.

Source componentwt. -%
Ammonia 25%0,62
Dipicolinic acid0,10
Disodium pyrophosphate0,03
Turpinal SL1,50
Techarp NSO2,00
Dow Corning DB 110 And0,07
Aculyn 33A (acrylic polymer)12,00
Hydrogen peroxide 50%solution22,40
Waterup to 100%

Texapon® NSO sodium salt of sulfate of simple lauric ether (approximately 27.5% of the active substance in water; designation item INCI name: sodium Laureth sulfate) (Cognis)

Aculyn® 33 acrylic polymer (about 28% solids in water; the designation in the INCI nomenclature: acrylate copolymer) (Rohm & Has)

Dow Corning® DB 110 And the non-ionic silicone emulsion (designation item INCI name: Dimethicone) (Dow Corning).

For the process of bleaching on the strands of hair dark brown, light brown and dark brown colors (marking: Keriing 7/0, Fischbach & Miller 6923 and Keriing 2/0),having a mass of approximately 0.7 g, was applied 4 times the amount of the final mixture, ready for use. Then the strands were subjected to blendirovanie for 30 minutes at 32°C, then washed with a conventional shampoo and dried with a Hairdryer.

2.1.3 Processing results in brightening abilities

Each strand of hair before and after the clarification process was evaluated colorimetrically. As a criterion brightening abilities of the respective formulation was used the value of the dL obtained by the following formula:

dL=Lafter-Lstartwhere Lafter=white strands after the clarification process; Lstart=white strands to the clarification process

For each formulation and each type of hair has made twelve measurements of individual results respectively obtained average value. The higher the value of dL, the better brightening ability to the relevant recipe.

Brightening ability in the case of dark brown strands (Kerling 7/0)

dL (V1)dL (V2)dL (E1)dL (E2)dL (E3)
10,812,612,813,613,2

Brightening ability in the case of a light chestnut strands (Fischbach & Miller 6923)

dL (V1)dL (V2)dL (E1)dL (E2)dL (E3)
12,112,813,614,113,8

Brightening ability in the case of dark chestnut strands (Kerling 2/0)

dL (V1)dL (V2)dL (E1)dL (E2)dL (E3)
5,36,98,06.87,2

2.1.4 interpretation of the results

Assessment brightening effect of different formulations can be made by comparing the values of dL. I had but obviously, using combinations according to the invention of the hydrogen peroxide, certain additional brightening activator action, as well as cationic derivative of azulfidine was able to reach much larger values of dL and, therefore, better clarification than was possible when using one of hydrogen peroxide or its combination with the derived azulfidine. Thus, by using this special combination of the three components were able to achieve significant improvements compared with the current level of technology.

1. Means for lightening keratin fibers, characterized in that it contains in a cosmetic carrier:
(i) 4-acetyl-1-methylpyridinium-p-toluensulfonate,
(ii) at least one toxicologically safe extra brightening activator and/or its physiologically acceptable salt, and
(iii) hydrogen peroxide.

2. The tool according to claim 1, characterized in that 4-acetyl-1-methylpyridinium-p-toluensulfonate is contained in an amount of from 0.01 to 25%, especially from 0.1 to 10%, respectively, calculated on the total weight of tools, ready to use.

3. The tool according to claim 1, characterized in that as an additional brightening activator and/or its physiologically acceptable salts it contains at least one Alif is political and/or carbocyclic additional brightening activator action.

4. The tool according to claim 1, characterized in that the additional brightening activator and/or its physiologically acceptable salt contains at least one functional group which is selected from: hydroxyl groups, carboxylic acids, complex monoether sulfuric acid or complex monoether phosphoric acid.

5. The tool according to claim 1, characterized in that as an additional brightening activator actions it contains at least one additional brightening activator actions corresponding to the formula (II), and/or its physiologically acceptable salt:

where Y represents a carbonyl group, a simple bond or a methylene group,
R1 is a hydrogen atom, alkyl group with carbon atoms of 1 to 4, a physiologically acceptable cation or groups SO3-or RHO32-,
R2 represents amino, methylamino-, dimethylamino-, trimethylammonium group, phenyl, benzyl, phenoxymethyl, 1-naphthyl, 2-naphthyl, 2-, 3-, 4-toluoyl or R4-O-(CH2CH2O)ngroup, and R4 is an alkyl group with carbon atoms of 6 to 20, and n is the number greater than 15,
R3 represents a hydrogen atom or an optionally branched alkyl group with carbon atoms of 1 to 6, provided that e is whether Y is a carbonyl group,
R1 is a hydrogen atom, alkyl group with carbon atoms of 1 to 4 or a physiologically acceptable cation,
R2 represents amino, methylamino-, dimethylamino - or trimethylammonio group, and
R3 is a hydrogen atom or an optionally branched alkyl group with carbon atoms of 1 to 6, and that
if Y is a simple link,
R1 is a hydrogen atom and
R2 represents phenyl, benzyl, phenoxymethyl, 1-naphthyl, 2-naphthyl, 2-, 3 - or 4-toluoyl, and
R3 is a hydrogen atom or an optionally branched alkyl group with carbon atoms of 1 to 6,
and that
if Y is a methylene group,
R1 is a group of SO3-or RHO32-,
R2 represents R4-O-(CH2CH2O)ngroup, and R4 is an alkyl group with carbon atoms of 6 to 20 and n equals the number is greater than 15,
and
R3 is a hydrogen atom.

6. The tool according to claim 1, characterized in that as an additional brightening activator actions it contains glycine and/or its physiologically acceptable salt.

7. The tool according to claim 1, characterized in that as an additional brightening activator actions it contains benzyl alcohol.

8. The tool according to claim 1, characterized in that as an additional brightening activator actions it contains a physiologically acceptable salt R4-O(CH 2CH2O)mSO3-in which R4 represents an alkyl group with carbon atoms of 6 to 20, a m number greater than 15.

9. The tool according to claim 1, characterized in that the additional brightening activator and/or its physiologically acceptable salt is present in an amount of from 0.01 to 10%, especially from 0.1 to 5% based on the total weight of tools, ready to use.

10. The tool according to claim 1, characterized in that it has a pH from 7 to 11.

11. Tool according to one of claims 1 to 10, characterized in that it additionally contains at least one inorganic salt of persulfate or peroxodisulfate, especially peroxodisulfate ammonium, peroxodisulfate potassium and/or peroxodisulfate sodium.

12. Way of lightening keratin fibers, characterized in that the means according to one of claims 1 to 11 is applied on the fibers containing keratin, leave these fibers for a time from 5 to 60 min, and then wash or wash out with shampoo.

13. The use according to one of claims 1 to 11 for clarification of fibers containing keratin, in particular human hair.



 

Same patents:

FIELD: chemistry.

SUBSTANCE: present inventions relate to protein engineering, plant molecular biology and pest control, as well as a hybrid insecticide protein and use thereof. Described is a hybrid insecticide protein which includes from the N-end to the C-end an N-end portion of Cry3A protein which is fused with the C-end portion of Cry1Ab protein, wherein the position of the crossover of the Cry3A protein and the Cry1Ab protein is located in a conservative block 2, in a conservative block 3 or in a conservative block 4 and has anti-western corn rootworm activity. Also disclosed are nucleic acid molecules which code the novel proteins, methods of producing proteins, methods for use thereof, as well as transgenic plants and seeds thereof which contain such proteins.

EFFECT: inventions enable to obtain cheap means of controlling Diabrotica worms.

39 cl, 8 dwg, 9 tbl, 46 ex

FIELD: chemistry.

SUBSTANCE: claimed invention relates to two-component hair dye, which includes first component, containing alkaline agent, second component, containing hydrogen peroxide, as well as non-aerosol vessel-foaming agent, intended for supply of liquid mixture of first component and second component in form of foam. Said liquid mixture contain anionic SAS, selected from components (A1)-(A3) or components (A4) and (A5), where component (A1) is represented by anionic SAS of carboxylate class, component (A2) is represented by anionic SAS of sulfonate class, component (A3) is represented by anionic SAS of phosphate class, component (A4) is represented by ionic SAS, and component (A5) is represented by alkanolamide of fatty acid. Also claimed invention relates to method of hair dyeing.

EFFECT: invention has good discoloration and dyeing capacities.

22 cl, 4 tbl, 22 ex

FIELD: medicine.

SUBSTANCE: invention refers to production of oral hygiene products. The presented oral care composition contains amorphous quartz having the particle size characterised by the fact that D90 makes less than 50 mcm, and one or more active substance is an antibacterial agent, and specified in a group consisting of cationic antibacterial agents specified in a group consisting of chlorhexidine, cetylpyridinium chloride, bisguanides, benzalkonium chloride, benzethonium chloride; metal salts specified in a group consisting of bivalent stanum salts, zinc salts, copper salts; and combinations thereof.

EFFECT: using amorphous quartz having good compatibility with the above antibacterial properties as a part of the product, particularly a tooth paste, provides storage-stable and high availability of the antibacterial product alongside with the effective and safe cleansing and polishing of the dental tissue.

8 cl, 2 ex, 30 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to preparing a mouthwash containing water, a moisturiser in the amount of 5 wt % to 15 wt % and 0.01 wt % - 5 wt % of a compound presented by the structure (III), wherein R1 and R2 are independently specified in hydrogen atoms, C2-6 -alkenyl group and C1-6 - alkyl group; and the compound (III) is dissolved in ethanol.

EFFECT: invention involves a method for reducing bacterial population on the substrate by substrate contact with the composition containing the compound of the structure (IV), wherein R1 and R2 are independently specified in the substituted or unsubstituted methyl group, substituted or unsubstituted ethyl group and substituted or unsubstituted butyl group.

11 cl, 1 tbl, 5 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to capsule suspensions prepared by coacervation, and to methods for reducing leakage of the capsule content in such suspensions during storage. Substance of the method for reducing leakage of the capsule content consists in storage of the capsules prepared by coacervation, in the capsule suspension containing min. 20 wt %, a moisturiser, which is at least a moisturiser specified in sorbitol, glycerol, polyethylene glycol, propylene glycol, xylitol, erythritol or betaine. What is also presented is the above capsule suspension containing at least one capsule prepared by coacervation and at least 20 wt % of the above moisturiser.

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21 cl, 4 tbl, 2 ex, 2 dwg

FIELD: medicine, pharmaceutics.

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EFFECT: invention provides better stability and cohesion.

12 cl, 5 ex, 3 tbl, 9 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to oral hygiene and personal hygiene compositions, and more specifically to compositions comprising a film immersed into a carrier, wherein the film contains a relatively high concentration of a zinc compound. According to the invention, the oral hygiene composition comprises the film immersed into the carrier wherein the zinc compound is found in the amount from approximately 35 wt % to approximately 60 wt %.

EFFECT: increase in the solid content in the film enhances the active compound delivery per a unit area that is important to achieve the highest delivery efficiency.

23 cl, 2 dwg, 14 tbl, 8 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to whitening tooth pastes, adducts therefor, and methods for preparing them. The adduct applicable for preparing a whitening formulation is prepared by mixing raw materials comprising peroxide, urea and an alkali metal polyphosphate in aqueous solution in the environment of temperature and/or pressure and/or agitation effective to prepare a solution of raw materials. The relation of (alkali metal polyphosphate) to (peroxide) in the aqueous solution of the adduct is matched with the relation of (anhydrous alkali metal polyphosphate) to (hydrogen peroxide 35 wt/wt % of the concentration) falling within the range of 0.05:1 to 0.5:1, and the adduct has pH in the aqueous solution that increases at least by 1.0 after ten introductions of the solution.

EFFECT: preparing the dental whitening formulation wherein the adduct is found in the aqueous environment, comprises a drug preparation and/or the adduct has pH in the aqueous solution that increases by at least 1,0 after ten introductions of the solution (and hence, in situ in the mouth when in use) that provides the excellent whitening properties thought to be ensured by the release of additional active peroxide ions onto the teeth when in use.

15 cl, 4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to dentistry, namely to a nonabrasive tooth paste. The presented nonabrasive tooth paste contains the initial ingredients as follows: papain, sphagnum extract, polymethylvinylether alcohol - maleic acid copolymer sodium calcium salt, N-cocoyl ethyl arginate D,L-pyrrolidone carboxylate and sodium fluoride, and sodium carboxymethylcellulose, an emulsifier, a preserving agent, a flavour, 70% sorbitol and demineralised water in the following proportions.

EFFECT: paste provides effective oral cleansing, plaque removal, destruction of pathogenic flora, remineralisation of the tooth enamel and reduction of the oral inflammation.

11 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to dentistry, namely to oral care products. The presented tooth paste has the following composition of the initial ingredients used for preparing the same: Streptococcus pyogenes group A, Enterococcus faecium, Enterococcus faecalis, Streptococcus sanguis, Staphylococcus aureus subsp. aureus, Klebsiella pneumoniae subsp. pneumoniae, Corynebacterium pseudodiphtheriticum, Fusobacterium nucleatum subsp. nucleatum, Candida albicans, Lactobacillus acidophilius, Lactobacillus fermentum, Lactobacillus helveticus, Lactobacillus delbrueckii subsp. Lactus bacterial lysates. enzymes, lysozyme and papain, and an abrasive ingredient, a moisturiser, a hydrocolloid, a surfactant, sodium fluoride, tetrapotassium pyrophosphate, a preserving agent, a flavour and water in certain proportions. The tooth paste possesses manifested cleansing, anti-inflammatory and haemostatic action.

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9 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, more specifically to pharmacology, neurology and cell engineering. What is described is using Napelline as a cerebroprotective agent. The mode of action of the agent is activation of cerebral neural stem cells.

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3 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, specifically to an agent showing antimicrobial activity.

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2 tbl, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely preparing an agent of hindu lotus seed extract (Nelumbo nucifera) possessing anxiolytic and antidepressive action. The agent possessing anxiolytic and antidepressive action prepared by extraction of hindu lotus seed extract (Nelumbo nucifera) in 50% ethanol in a Soxhlet extraction apparatus in the specific proportions.

EFFECT: agent possess the effective anxiolytic and antidepressive action.

3 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely to a method for preparing an enterosorbent. The method for preparing the enterosorbent involving milling birch bark, activating in evaporated water under certain conditions, processing in 0.5-2.0% alkali for 30-60 min, water flushing, nautralising, condensing and drying to the air-dry condition.

EFFECT: enterosorbent prepared by the method described above is characterised by high methylene blue sorption capacity and gelatine sorption capacity.

1 tbl, 5 ex

FIELD: medicine.

SUBSTANCE: declared invention refers to veterinary science, and aims at treating gastrointestinal diseases in calves. A method involves using the subcutaneous injections of convascelent's blood serum containing rota- and coronavirus antihemagglutinin in titres 1:128 and 1:64 respectively. The serum is introduced in a dose of 10.0 ml once a day for 9 days every 48 hours. That is combined with administering an infusion of a milled mixture of equal portions of purple Echinacea herb and blossom clusters (Echinazea purpurea), coltsfoot herb (Tussilago farfara), tillet blossom (Tilia cordata) and liquorice root (Glycyrrhiza glabra) prepared with the relation of the raw material to extractant that is 70% alcohol - 1:10 and kept at temperature 15-20°C for 7 days in the form of 7-8% aqueous solution in a dose of 3.5-4.5 ml/kg of animal's body weight every 12 hours to the clinical recovery.

EFFECT: use of the declared invention provides the higher body resistance and faster recovery of the animal's body micro- and macroelement balance.

5 tbl, 3 ex

Immunomodulator // 2497514

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry, and represents an immunomodulator for treating chronic hepatitis, hepatic cancer, lymphatic sarcoma, chronic leukemia, and for improving the functions of liver and blood-forming organs, for enhancing the immunobiological body characteristics, prepared by mixing 1000 ml of an aqueous infusion of sandy everlasting blossom, pepper mint herb and chicory herb with 50 ml of bovine serum containing leukaemia oncovirus antibodies, 20 ml of wild rosemary infusion, 40 g of ascorbic acid, 2 g of sorbic acid, 0.2 g of folic acid until the ingredients are dissolved completely, with adding 60 g of liver powder, 30 g of lymphatic node powder, 30 g of young bovine spleen powder; the prepared solution is settled at room temperature for 24 hours, then kept at a boiling water bath for 30 minutes and cooled for 6-8 hours at room temperature; the settled solution is filtered, wherein the aqueous herbal solution is prepared by mixing equal proportions of the separately prepared aqueous infusions of 40 g of pepper mint herb in 1000 ml of water, 30 g of sandy everlasting blossom in 1000 ml of water and 30 g of chicory herb in 1000 ml of water, while the wild rosemary infusion is prepared by infusing 60 g of ground wild rosemary blossom in 1000 ml of 70% purified ethanol.

EFFECT: invention provides creating the high-efficacy agent and reducing the length of treatment.

FIELD: chemistry.

SUBSTANCE: claimed invention relates to two-component hair dye, which includes first component, containing alkaline agent, second component, containing hydrogen peroxide, as well as non-aerosol vessel-foaming agent, intended for supply of liquid mixture of first component and second component in form of foam. Said liquid mixture contain anionic SAS, selected from components (A1)-(A3) or components (A4) and (A5), where component (A1) is represented by anionic SAS of carboxylate class, component (A2) is represented by anionic SAS of sulfonate class, component (A3) is represented by anionic SAS of phosphate class, component (A4) is represented by ionic SAS, and component (A5) is represented by alkanolamide of fatty acid. Also claimed invention relates to method of hair dyeing.

EFFECT: invention has good discoloration and dyeing capacities.

22 cl, 4 tbl, 22 ex

FIELD: medicine.

SUBSTANCE: invention refers to production of oral hygiene products. The presented oral care composition contains amorphous quartz having the particle size characterised by the fact that D90 makes less than 50 mcm, and one or more active substance is an antibacterial agent, and specified in a group consisting of cationic antibacterial agents specified in a group consisting of chlorhexidine, cetylpyridinium chloride, bisguanides, benzalkonium chloride, benzethonium chloride; metal salts specified in a group consisting of bivalent stanum salts, zinc salts, copper salts; and combinations thereof.

EFFECT: using amorphous quartz having good compatibility with the above antibacterial properties as a part of the product, particularly a tooth paste, provides storage-stable and high availability of the antibacterial product alongside with the effective and safe cleansing and polishing of the dental tissue.

8 cl, 2 ex, 30 dwg

FIELD: medicine.

SUBSTANCE: invention refers to using a tracer agent for magnetic particle imaging (MPI) for the purpose of visual monitoring of a biocompatible product. The biocompatible product contains the tracer agent for magnetic particle imaging (MPI) by imaging technique using magnetic particles. The biocompatible product represents a microcontainer comprising a solid or semi-solid material applicable for cell culture support. The invention also refers to a method for visual monitoring of the biocompatible product. The declared method involves the stages of providing the biocompatible product containing the tracer agent for MPI, introducing the biocompatible product into a target area, and detecting signals generated by the tracer agent for MPI by imaging technique using magnetic particles.

EFFECT: invention provides monitoring of the targeted cell or active agent delivery into the target area.

10 cl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely a method for preparing an agent possessing immunomodulatory activity. The method for preparing an agent possessing immunomodulatory activity characterized by the fact that herbal composition containing common motherwort herb, knotgrass herb, pot marigold blossom, licorice rhizome and root, Alexandrian laurel rhizome and root, rosehip, schizandra fruit, linseeds, sequentially twice extracted in 60-70% ethanol, twice in 40-50% ethanol, and once in purified water under specific conditions; then the aqueous-alcoholic extracts are concentrated in vacuum; the aqueous still residues are combined with the aqueous extract, then filtered, boiled out, purified by separation, boiled out additionally, dried in a vacuum dryer and further milled.

EFFECT: method enables preparing the agent possessing manifested immunomodulatory activity with the high content of active substances.

13 tbl, 2 ex

FIELD: medicine, oncology, amino acids.

SUBSTANCE: invention relates, in particular, to the development of an antitumor preparation based on natural substances. Invention relates to an amino acid preparation comprising at least one modified essential amino acid obtained by treatment of amino acid by ultraviolet radiation (UV) at wavelength 250-350 nm for 12-80 h at temperature 15-30oC or with ozone at temperature 15-25oC. The modified amino acid has no toxicity for health cells. Also, invention relates to a method for preparing such preparation. Invention provides the development of an antitumor preparation based on modified amino acids and expanded assortment of antitumor preparations being without cytotoxicity for normal cells.

EFFECT: valuable medicinal antitumor properties of preparation.

8 cl, 4 tbl, 2 dwg, 4 ex

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