Storage-stable capsules

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to capsule suspensions prepared by coacervation, and to methods for reducing leakage of the capsule content in such suspensions during storage. Substance of the method for reducing leakage of the capsule content consists in storage of the capsules prepared by coacervation, in the capsule suspension containing min. 20 wt %, a moisturiser, which is at least a moisturiser specified in sorbitol, glycerol, polyethylene glycol, propylene glycol, xylitol, erythritol or betaine. What is also presented is the above capsule suspension containing at least one capsule prepared by coacervation and at least 20 wt % of the above moisturiser.

EFFECT: using the above moisturiser in the amount of min 20 wt % provides reducing the leakage rate of the capsule content.

21 cl, 4 tbl, 2 ex, 2 dwg

 

The level of technology

The capsules obtained using the method of complex koatservatsii, often supplied in the form of an aqueous suspension. Often, the encapsulated material can diffuse from the shell of the capsule through the pores of the capsules in the liquid phase due to the concentration gradient. Leaks can lead to loss of encapsulated materials. In various fields of applications, such as compositions for cleaning teeth, can be a desirable reduction in the rate of leakage from the capsule and increasing the stability of the capsules.

Description of the drawings

Figure 1 shows the kinetics of release from the capsules flavor obtained using koatservatsii; and

Figure 2 shows the initial phase of the kinetics of release from the capsules flavor obtained using koatservatsii.

The invention

In accordance with some of the options for the implementation of the suspension of capsules includes at least one capsule obtained by koatservatsii, and at least 10% of the mass. the humidifier. Found that the humidifier reduces the leakage of the contents from the capsule.

In accordance with some of the options for implementation, a method of reducing leakage, at least one of the capsules obtained by koatservatsii includes storing the capsules obtained by koatservatsii, suspension capsules, which contains the inhabitants, at least 10% of the mass. the humidifier.

Detailed description of the invention

As used herein, the ranges are used as abbreviations for describing each and every value that is within this range. Any value in the range may be chosen as a limit of this range.

In accordance with some of the options for implementation, suspension capsules contains capsules obtained by koatservatsii. In some embodiments, implementation, capsules are capsules-type core-shell.

Capsules can contain any content that is appropriate for the environment of the oral cavity. For example, in certain embodiments of the implementation, the capsules contain the active ingredients, flavorings and/or pigments. Content can take many forms, such as liquid, solid, powder and/or gel.

Examples suitable for use active ingredients include, but are not limited to, means for preventing dental caries, antibiotics, vitamins, enzymes, anti-inflammatory agents, and combinations thereof. More specifically, examples include, but are not limited to, sodium fluoride, tin fluoride, sodium monitoroff, vitamin E, vitamin C, dextranase, Mutsu, sodium chloride, glycyrrhizinate, glycyrrhetic acid, azulene, di is idaholottery, chlorhexidine, epichlorhydrin, isopropylethylene, trichlorocarbanilide, triclosan, Halocarbon, hinokitiol, allantoin, tranexamic acid, propoli, pyridinium chloride, benzathine chloride, benzalconi chloride, sodium copper of chlorophyllin, and lysozyme chloride.

Examples of suitable flavoring agents may include, but are not limited to, aromatic aldehydes, esters and alcohols. More specifically, examples include, but are not limited to, oil of spearmint, peppermint oil, clove oil, Clary sage essential oil, eucalyptus oil, Bay oil, cinnamon oil, lemon-lime oil, grapefruit oil, menthol, carvon, methyl salicylate, utililities, eugenol, camphor oil, ginger, ethyl acetate, diethylketone, eucalyptol, pepper, rose, isopropylethylene, maltol and anethole.

Suitable for use pigments and dyes may include inorganic and/or organic pigments. More specifically, examples may include, but are not limited to, inorganic pigments such as cobalt blue, cobalt green, yellow ferric oxide, titanium oxide, mica, powdered zinc, and aluminum powder; dyes, such as Blue No. 1 and No Red. 2; and other pigments such as chlorophyll copper, beta-carotene and complexes of salts of iron and hinokitiol.

In certain embodiments is sushestvennee, capsule contents mixed with fillers, such as fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, esters, essential oils, and silicone oils. Examples suitable for use fats and oils may include, but are not limited to, natural fats and oils such as soybean oil, rice bran oil, jojoba oil, avocado oil, almond oil, olive oil, cacao butter, sesame oil, peach oil, castor oil, coconut oil, mink oil, beef tallow and lard; hydrogenated oil obtained by hydrogenation of natural fats and oils; and synthetic triglycerides, such as maristany the glycerides, 2-ethylhexanoyl the glycerides, tricaprylate the glycerides and tricarinatus the glycerides. Examples of usable waxes may include, but are not limited to, Carnauba wax, beeswax fatty tissues of the whale, beeswax and lanolin. Examples of suitable hydrocarbons may include, but are not limited to, liquid paraffins, petrolatum, paraffin waxes, microcrystalline waxes, ceresin, squalane and the Wharf. Examples suitable for use of higher fatty acids may include, but are not limited to, lauric acid, myristic acid, palmitic acid, stearic acid, beenbuy acid, aleinov the Yu acid, linoleic acid, linolenic acid, lanolin acid and isostearoyl acid. Examples of usable higher alcohols may include, but are not limited to, lauric alcohol, cetyl alcohol, stearyl alcohol, alerby alcohol, lanolin alcohol, cholesterol and 2-hexyldecanol. Examples of usable esters may include, but are not limited to, tetrachromat, myristylated, catallactic, isopropylmyristate, myristoleate, isopropyl, isopropylacetate, butilstearat and decollet. Examples of essential oils may include, but are not limited to, oil meadow mint, Jasmine oil, camphor oil, oil of Chamaecyparis tupolisty, oil Golden mustache, Rutaceae oil, turpentine oil, cinnamon oil, bergamot oil, citrus oil, airnogo oil, pine oil, lavender oil, Bay oil, clove oil, oil of thevice Japanese, rose oil, eucalyptus oil, lemon oil, peppermint oil and sage oil. Examples of silicone oils include dimethylpolysiloxane.

In some embodiments, the implementation, the core of the capsule is a liquid. In some embodiments, the implementation, the core of the capsule is a hard material. In certain embodiments of the implementation, the core of the capsules is from the battle of the combined liquid and solid material.

In certain embodiments of the implementation capsule form by way koatservatsii. In some embodiments, implementation, capsules are formed by the method of complex koatservatsii. Can be used ways koatservatsii known in this field, including, for example, those described in U.S. patent No. 6045835, the content of which is incorporated herein by reference. The average particle size for capsules can range from 1 to 3000 μm, from 50 to 2000 microns, or from 500 to 1500 microns. Capsules can have an average thickness of 10 to 40 microns, although it can be used any desired thickness.

The ratio of core to shell capsules can be any size suitable for the desired end product and/or method of processing, alleged for the final product. It may be, for example, 10 : 1, 12 : 1, 16 : 1, and/or 20 to 1; however, may be any suitable ratio if this ratio provides sufficient stability of the capsules during manufacture and makes it possible quite easily fracture during use.

After implementing the method koatservatsii, capsules may be washed to remove residual material, and then be included in a representative preparation of a suspension containing other ingredients, such as a humidifier.

In accordance with some of the options for implementation, the capsules are stored when they are in suspension together with additional components. In some embodiments, the implementation, the slurry is water. In certain embodiments of the implementation, the suspension contains from 1 to 80 wt%. water. In some embodiments, the implementation of the suspension contains from 1 to 70 wt%. water. In some embodiments, the implementation of the suspension contains from 1 to 50 wt%. water. In some embodiments, the implementation of the suspension contains from 1 to 40 wt%. water. In some embodiments, the implementation of the suspension contains from 1 to 30 wt%. water. In some embodiments, the implementation of the suspension contains from 1 to 20 wt%. water. In some embodiments, the implementation of the suspension contains from 1 to 15% of the mass. water. In other embodiments, the implementation, the suspension does not contain water.

In some embodiments, the implementation of the suspension contains at least one humectant. Examples suitable for use humidifiers may include, but are not limited to, sorbitol, glycerin, polyethylene glycol, propylene glycol, aritra and betaine. In some embodiments, the implementation of the suspension contains at least 15% of the mass. the humidifier. In some embodiments, the implementation of the suspension contains at least 20% of the mass. the humidifier. In some embodiments, implementation, suspe the Zia contains, at least 40% of the mass. the humidifier. In some embodiments, the implementation of the suspension contains at least 65% of the mass. the humidifier. In some embodiments, the implementation of the suspension contains at least 80% of the mass. the humidifier.

In accordance with some of the options for implementation, the suspension contains capsules, as described above. In some embodiments, the implementation, the suspension may contain from 5 to 65% of the mass. the capsules. In some embodiments, the implementation, the suspension may contain from 20 to 50 wt%. the capsules. In some embodiments, the implementation, the suspension may contain from 30 to 35% of the mass. capsules.

In accordance with some of the options for implementation, the suspension contains thickening agents. The suspension can contain any usable thickening agent. Examples suitable for use thickening agents may include, but are not limited to, xanthan resin, salt, sodium carboxymethylcellulose, sodium polyacrylate, hydroxyethyl cellulose, anhydrous silicon dioxide, montmorrilonite, carrageenan, sodium alginate, guar gum and pectin. In some embodiments, the implementation of the suspension contains up to 10% of the mass. thickening agent. In certain embodiments of the implementation, the suspension contains up to 5% of the mass. thickening agent. In some embodiments, the implementation of the suspension contains up to 1% m is ssegawa agent.

In certain embodiments of the implementation, the suspension contains preservatives. The suspension may contain any suitable preservative. Examples of suitable preservatives may include, but are not limited to, potassium sorbate, benzoic acid, sodium benzoate, parabens, esters parahydroxybenzoic acids, and the like. In some embodiments, the implementation of the suspension contains any usable amount of preservatives. In some embodiments, the implementation of the suspension contains up to 10% of the mass. preservatives. In other embodiments, the implementation of the suspension contains up to 5% of the mass. preservatives. In certain embodiments of the implementation, the suspension contains up to 1% of the mass. preservatives.

In accordance with some of the options for the implementation of the suspension of capsules is included in the composition for cleaning teeth. Composition for cleaning teeth may take any desired shape, including toothpastes, tooth powders, pastes, gels, rinses, lozenges, chewing gum, and the like.

In some embodiments, the implementation, the composition for cleaning teeth contains up to 30% of the mass. suspension capsules. In certain embodiments of the implementation, the composition for cleaning teeth contains up to 15% of the mass. suspension capsules. In other embodiments, about what westline, composition for cleaning teeth contains up to 5% of the mass. suspension capsules. In some embodiments, the implementation, the composition for cleaning teeth contains 1% of the mass. suspension capsules.

In some embodiments, the implementation, the composition for cleaning teeth includes such materials as sources of fluoride ions, the agents against the formation of dental calculus, buffers, abrasive materials, sources peroxide, bicarbonate alkali metal salts, thickening materials, humectants, water, surfactants, flavoring agents, sweetening agents, coloring agents and mixtures thereof. In certain embodiments of the implementation, the composition for cleaning teeth includes the usual components of toothpastes, tooth powders, prophylactic pastes, gels, mouthwashes, lozenges, chewing gum, and the like.

In some embodiments, the implementation, the composition for cleaning teeth contains water. In some embodiments, the implementation, the composition for cleaning teeth contains water in an amount of from 1 to 95% by mass. In some embodiments, the implementation, the composition for cleaning teeth contains water in an amount from 1 to 50 wt%. In some embodiments, the implementation, the composition for cleaning teeth contains water in an amount of from 10 to 40% of the mass. water.

Composition means for Chi the TCI teeth may also contain a humectant. In some embodiments, implementation, humectant comprises glycerin, sorbitol, aritra, betaine or allenglish, such as polyethylene glycol or propylene glycol. In some embodiments, the implementation, the humectant is present in an amount of from 15 to 95% of the mass. from the composition for cleaning teeth. In other embodiments, implementation, humectant is present in an amount of from 45 to 85 wt. -%

Composition for cleaning teeth may contain inorganic or natural or synthetic thickening or gelling agent. In some embodiments, implementation, thickening or gelling agent is present in an amount up to 10% of the mass. Other levels that may be suitable for use include from 0.25% to 5%, from 0.5% to 4% and/or from 1% to 3% of the mass. with respect to the total composition. In some embodiments, implementation, composition for cleaning teeth for suspension of the capsules included usable amount of thickening agent or abrasive granules or balls. In some embodiments, implementation, suitable for use amount of thickening agent is included in the composition for cleaning teeth for forming extrudable, preserving the shape of the product, which can be squeezed out from a tube onto a toothbrush and will not fall between the bristles is etki, but instead, will essentially retain its shape on them. Suitable for use thickening or gelling agents for compositions for cleaning teeth may include inorganic thickening silicon oxides available from Huber Corporation, Edison, New Jersey under the trade designation Zeodent 165, carrageen, carragenan, the resin tragakant, polyvinylpyrrolidone, xanthan resin, sodium salt of carboxymethyl cellulose, sodium polyacrylate, hydroxyethyl cellulose, anhydrous silicon dioxide, montmorillonite, sodium alginate, guar gum, silicates, alkali metal silicates, such as laponite and pectin.

In some embodiments, the implementation, the composition for cleaning teeth includes at least one surfactant. Usable surfactants may include, but are not limited to, water-soluble salts monosulfate of monoglycerides of higher fatty acids, such as sodium salt monoculturing monoglyceride hydrogenated fatty acids of coconut oil, cocamidopropylbetaine, higher alkyl sulphates, such as sodium laurylsulfate, alkylarylsulfonate, such as sodium dodecylbenzenesulfonate, higher alkylsulfonates, sodium laurilsulfate, esters of higher fatty acids and 1,2-dihydroxydiphenylsulfone, and su is estu saturated higher aliphatic acylamide compounds of lower aliphatic aminocarbonyl acids, such as those that have 12 to 16 carbon atoms in the fatty acid, alkyl or acyl radicals, and the like. Examples of suitable amides may include N-lauroylsarcosine and salts of sodium, potassium and ethanolamine and N-lauroyl-, N-myristoyl - or N-palmitoylcarnitine.

In some embodiments, the implementation, the composition for cleaning teeth contains up to 5.0% of the mass. surface-active substances. In other embodiments, implementation, composition for cleaning teeth contains from 0.5 to 2.5 wt%. surface-active substances. In some embodiments, the implementation, the composition for cleaning teeth contains up to 1% of the mass. surface-active substances.

Composition for cleaning teeth may also contain a binding agent. Examples of usable binder agents may include, but are not limited to, marine colloids, carboxyvinyl polymers, carragenan, starches, water-soluble ethers of cellulose such as hydroxyethylcellulose, carboxymethylcellulose (carmellose), hydroxypropylmethyl cellulose and their salts (e.g. sodium carmelose), natural resins such as gum karaya, xanthan gum, Arabic gum and resin tragakant, chitosan, colloidal magnesium-aluminum silicate, and colloidal silicon dioxide. In some embodiments, implementation of CBE the respective agents are present in amounts of from 0.1 to 1.5% of the mass.

Composition for cleaning teeth may also contain flavoring or a mixture of flavors, including natural or synthetic flavoring agents, such as aromatic oils, aromatic aldehydes, esters, alcohols, and similar materials, and combinations thereof. Examples of suitable flavoring agents may include vanilla, mint oil, cinnamon oil, oil of Wintergreen (methyl salicylate), peppermint oil, clove oil, anise oil, eucalyptus oil, citrus oils, fruit oils and essences. In some embodiments, the implementation, the composition for cleaning teeth can include flavorings, such as lemon, Menton, carvon, menthol, anethole, eucalyptus oil, eucalyptol, eugenol, the aroma of acacia, Oksanen, alpha ireson, propylgallate, thymol, linalool, benzaldehyde, cinnamaldehyde, N-ethyl-p-Menten-3-carboxamide, N-2,3-trimethyl-2-isopropylmalonic, 3,1-methoxypropane-1,2-diol, cinnamylpiperazine (CGA), entepicondylar (MGA) and cineole.

In some embodiments, the implementation, the composition for cleaning teeth can also include an abrasive. The abrasive may act as mechanical and physical means for exfoliation and increased desquamation of oral mucosa. In some embodiments, the implementation, the abrasive is distributed is via oral acceptable filler.

In some embodiments, the implementation, the composition for cleaning teeth contains abrasives on the basis of silicon dioxide. Examples of suitable abrasives include, but are not limited to, abrasives based on silicon dioxide, such as precipitiously oxides of silicon, sodium metaphosphate, potassium metaphosphate, tricalcium phosphate, digidrirovanny dicalcium phosphate, aluminum silicate, calcined alumina, bentonite or other siliceous materials, thermoplastic resin in the form of particles, such as melamine, phenolic compounds and urea-formaldehydes, and cross stitched polyepoxide and polyesters.

The abrasive can be present in any usable quantity. In some embodiments, the implementation of such abrasives are present in amount from 1 to 50 wt%. In other embodiments, the implementation of such abrasives are present in an amount of from 10 to 40 mass percent. In other embodiments, the implementation of such abrasives are present in an amount of from 18 to 20 percent of the mass.

Other additives may be included in a composition for cleaning teeth for reasons connected with obtaining, stability, aesthetics, therapeutic effect, users need and like. Illustrative additives include all the usual additives to the means for isdi teeth, the viscosity modifiers, diluents, modulators of foaming agents that stimulate salivation, antisense agents, whitening agents, enzymes agents, pH modifier, agents, giving a flavour, sweeteners, colorants, cloud emulsions and agents, breath freshening.

In accordance with some of the options for implementation of the present invention, the suspension capsules contains capsules obtained by koatservatsii, and at least 10% of the mass. the humidifier. In some embodiments, implementation, storage capsules obtained by koatservatsii, suspension capsules, which contains at least 10% of the mass. the humidifier reduces the leakage of the contents of the capsules obtained by koatservatsii.

Referring to figure 1, in some embodiments, the implementation of leakage of the contents from the capsules flavor obtained by the method of complex koatservatsii shows biphasic kinetics. As shown in figure 1, in certain embodiments of the implementation, the leakage by using the initial fast phase with a lifetime in the time scale of weeks/months, followed by a slow phase equilibrium. Referring to Figure 2, a detailed analysis of the kinetics of the fast phase shows that in certain embodiments implement the leakage rate should kinetics zero then the dka. As shown in figure 2, in some embodiments, the implementation of the flavoring component is moving at constant speed; speed is the angle of slope of linear fit of data leakage.

In accordance with some of the options for implementation, capsules are kept in suspension to reduce leakage from the capsule. In some embodiments, implementation, capsules are kept in suspension, which contains at least 15% of the mass. the humidifier. In some embodiments, implementation, capsules are kept in suspension, which contains at least 20% of the mass. the humidifier. In some embodiments, implementation, capsules are kept in suspension, which contains at least 40% of the mass. the humidifier. In some embodiments, implementation, capsules are kept in suspension, which contains at least 65% of the mass. the humidifier. In some embodiments, implementation, capsules are kept in suspension, which contains at least 80% of the mass. the humidifier. In certain embodiments of the implementation of the capsules produced using the koatservatsii.

In accordance with some of the options for implementation, the rate of leakage of the contents of the capsules contained in the suspension is less than 4e-10 M/sec at room temperature. In some embodiments, the implementation, the rate of leakage of the contents of the capsules contained in the suspension is less than h is m 4e-11 M/sec, at room temperature. In some embodiments, the implementation, the rate of leakage of the contents of the capsules contained in the suspension is less than 1,5e-11 M/sec at room temperature.

In accordance with some of the options for implementation, the rate of leakage of the contents of the capsules contained in the suspension is less than 1e-9 M/s, at 40°C. In some embodiments, the implementation, the rate of leakage of the contents of the capsules contained in the suspension is less than 1e-10 M/s, at 40°C. In certain embodiments of the exercise, the rate of leakage of the contents of the capsules contained in the suspension is less than 8e-11 M/s, at 400C.

In accordance with some of the options for implementation, the rate of leakage of the contents of the capsules contained in the suspension is less than 1,5e-9 M/s at 49°C. In certain embodiments of the exercise, the rate of leakage of the contents of the capsules contained in the suspension is less than 1,5e-10 M/s at 49°C. In some embodiments, the implementation, the rate of leakage of the contents of the capsules contained in the suspension is less than 1e-10 M/s at 49°C.

The activity in the water for a suspension is defined as the vapor pressure of water above the sample suspension divided by the vapor pressure of pure water at the same temperature and pressure. It is measured using a hygrometer with a dew point. In some embodiments, the implementation of the suspension is active the th water at 23°C less than 0,97. In certain embodiments of the implementation, the slurry has a water activity at 23°C less than 0.95. In some embodiments, the implementation, the slurry has a water activity at 23°C less than 0,94. In some embodiments, the implementation, the slurry has a water activity at 23°C less than 0.90. In some embodiments, the implementation, the slurry has a water activity at 23°C less than 0,85.

In accordance with some of the options for implementation, the number of the humidifier in the suspension associated with the rate of leakage from the capsules contained in the suspension. In some embodiments, the implementation, the rate of leakage of the contents of the capsules is inversely proportional to the number of the humidifier in suspension. In certain embodiments the higher the concentration of the humidifier in suspension leads to a lower rate of leakage from the capsules contained in the suspension.

In accordance with some of the options for implementation, the number of the humidifier in suspension related to the activity of water in suspension. In certain embodiments of the implementation of the activity in the water slurry is inversely proportional to the concentration of the humidifier in suspension. In some embodiments, implementation, higher concentration of the humidifier in suspension leads to a lower water activity in suspension.

In some embodiments, implementing the tvline, water activity for the suspension associated with the rate of leakage from the capsules contained in the suspension. In certain embodiments of the implementation of the activity in the water in suspension has a direct relationship with the rate of leakage from the capsules contained in the suspension. In some embodiments, implementation, lower water activity for the suspension leads to a lower rate of leakage from the capsules contained in the suspension.

In accordance with some of the options for implementation of the capsules contained in the composition for cleaning teeth to reduce leakage from the capsules. In some embodiments, implementation of the capsules contained in the composition for cleaning teeth, containing a humectant in an amount of from 15 to 95% of the mass. from the composition for cleaning teeth. In other embodiments, implementation of the capsules contained in the composition for cleaning teeth, containing a humectant in an amount of from 45 to 85% by mass. In certain embodiments of the implementation of the capsules produced using the koatservatsii.

In accordance with some of the options for implementation, the rate of leakage of the contents of the capsules contained in the composition for cleaning teeth, less than 5e-9 M/sec at room temperature. In some embodiments, the implementation, the rate of leakage of the contents of the capsules provided is camping in the composition for cleaning teeth less than 1e-9 M/sec at room temperature. In some embodiments, the implementation, the rate of leakage of the contents of the capsules contained in the composition for cleaning teeth, less than 3e-10 M/ sec at room temperature.

In accordance with some of the options for implementation, the rate of leakage of the contents of the capsules contained in the composition for cleaning teeth, less than 7e-9M/s at 40°C. In some embodiments, the implementation, the rate of leakage of the contents of the capsules contained in the composition for cleaning teeth, less than 4e-9 M/s, at 40°C. In certain embodiments of the exercise, the rate of leakage of the contents of the capsules contained in the composition for cleaning teeth, less than 2e-9 M/s, at 40°C.

In accordance with some of the options for implementation, the rate of leakage of the contents of the capsules contained in the composition for cleaning teeth, less than 8e-9 M/s at 49°C. In certain embodiments of the exercise, the rate of leakage of the contents of the capsules contained in the composition for cleaning teeth, less than 6e-9 M/s at 49°C. In some embodiments, the implementation, the rate of leakage of the contents of the capsules contained in the composition for cleaning teeth, less than 5e-9 M/s at 49°C.

In some embodiments, the implementation, the composition for cleaning teeth is active is there water at 23°C less than 0.95. In certain embodiments of the implementation, the composition for cleaning teeth has a water activity at 23°C less than 0.90. In some embodiments, the implementation, the composition for cleaning teeth has a water activity at 23°C less than 0,80. In some embodiments, the implementation, the composition for cleaning teeth has a water activity at 23°C less than 0,70. In some embodiments, the implementation, the composition for cleaning teeth has a water activity at 23°C less than 0,60.

In accordance with some of the options for implementation, the amount of humectant in the composition for cleaning teeth is associated with the rate of leakage from the capsules contained in the composition for cleaning teeth. In some embodiments, the implementation, the rate of leakage of the contents of the capsules is inversely proportional to the amount of humectant in the composition for cleaning teeth. In certain embodiments of the exercise, the higher the concentration of the humectant in the composition for cleaning teeth leads to a lower rate of leakage from the capsules contained in the composition for cleaning teeth.

In accordance with some of the options for implementation, the amount of humectant in the composition for cleaning teeth is associated with activity in the water for composition for cleaning teeth. In particular the military variants of implementation, water activity of the composition for cleaning teeth is inversely proportional to the concentration of the humectant in the composition for cleaning teeth. In some embodiments, implementation, higher concentration of humectant in the composition for cleaning teeth leads to lower water activity of the composition for cleaning teeth.

In some embodiments, the implementation of the activity in the water composition for cleaning teeth is associated with the rate of leakage from the capsules contained in the composition for cleaning teeth. In certain embodiments of the implementation of the activity in the water composition for cleaning teeth is in direct communication with the rate of leakage of the contents of the capsules contained in the composition for cleaning teeth. In some embodiments, implementation, lower water activity for composition for cleaning teeth leads to a lower rate of leakage from the capsules contained in the composition for cleaning teeth.

Examples

The following additional examples describe and demonstrate embodiments of the present invention. These examples are provided for illustrative purposes only and should not be construed as limiting the present invention since many variations are possible the mi without deviating from the spirit and scope.

Example 1: Drugs suspension capsules

Drugs suspension of capsules capsules obtained by koatservatsii containing flavors, prepared without sorbitol, 20% of the mass. sorbitol and 40% of the mass. sorbitol, labeling them as A, B, and C, respectively. Table 1 lists the contents in mass% and water activity (Aw) at 23°C for each drug suspension capsules.

0,5
Table 1
Water activity for drugs suspension capsules
Formula (% mass)ABC
Water66,246,226,2
Sorbitol (active substance)-2040
Capsule with flavoring333333
Xanthan gum0,20,20,2
Potassium sorbate0,50,5
Awat 23°C0,970,910,84

The data show that a higher concentration of sorbitol corresponds to a lower leak rate at each temperature.

Table 2 provides leak rate (M/sec) content flavoring for capsules, obtained using koatservatsii contained in the suspensions at different temperatures.

Table 2
The rate of leakage of the flavor of the capsules in suspension (M/sec)
TemperatureABC
Room temperatureof 3.4×10-94,0×10-11of 1.4×10-11
40°C4,5×10-9of 9.8×10-11of 7.9×10-11
49°C of 7.4×10-9of 1.4×10-10the 9.7×10-11

The data show that a higher concentration of sorbitol suspension capsules corresponds to lower the water activity at 23°C in suspension capsules.

Example 2: Compositions for cleaning teeth containing capsules, and leak rate

Composition for cleaning teeth containing capsules obtained by koatservatsii, filled with flavor, prepared with different amounts of humectant and water. Capsules filled with flavor, have the outer coating of the 93% of triglycerides of medium chain length and 7% protein surrounding liquid flavoring, which ranges from 20 to 30% of the mass. the capsule. Table 3 provides the content in mass percent and a water activity (Aw) at 23°C for each composition for cleaning teeth.

Table 3
Liquid compositions for cleaning teeth
Formula (% mass)ABC
Water402510
Glycerin102540
Dental silica - abrasive202020
Dental silicon dioxide - thickening agent4,24,24,2
Sorbitol14,614,614,6
PEG 600333
Pluronic F1271,51,51,5
Betaine CAP111
SLS111
Resin CMC1,51,51,5

The aroma of peppermint0,7 0,7
Na Saccharin0,50,50,5
Tetranitro pyrophosphate0,50,50,5
Sodium fluoride0,30,30,3
Parabens0,10,10,1
Capsule with flavoring111
Awat 23°C0,880,780,59

Data show that the higher the concentration of the humectant in the composition for cleaning teeth corresponds to a lower water activity at 23°C for compositions for cleaning teeth.

Composition for cleaning teeth with capsules obtained by koatservatsii and containing flavors, prepared with different amounts of humectant and water, which are given in Table 3 as A, B and C. table 4 causes the leakage rate (M/sec content flavoring for capsules obtained using koatservatsii contained in the composition for cleaning teeth, at different temperatures.

Table 4
The rate of leakage of the flavor of the capsules in the composition for cleaning teeth (M/sec)
TemperatureABC
Room temperature4×10-99×10-102×10-10
40°C6×10-93×10-91×10-9
49°C7×10-95×10-94×10-9

The data show that a higher concentration of glycerol corresponds to a lower leak rate at each temperature.

1. Suspension of capsules containing,
at least one capsule obtained by koatservatsii; and,
at least 20 wt.% the humidifier
the humidifier is, at least, one of the n humidifier, selected from sorbitol, glycerol, polyethylene glycol, propylene glycol, xylitol, erythrite or betaine.

2. Suspension of capsules according to claim 1, in which the humidifier is a sorbitol.

3. Suspension of capsules according to claim 1, in which the humidifier is a glycerin.

4. Suspension of capsules according to claim 1, in which the humectant is at least one humidifier from polyethylene glycol, propylene glycol, xylitol, erythrite or betaine.

5. Suspension of capsules according to any one of the preceding paragraphs, where the suspension of capsules contains at least 40 wt.% the humidifier.

6. Suspension of capsules according to claim 5, in which the suspension of capsules contains at least 65 wt.% the humidifier.

7. Suspension of capsules according to claim 6, in which the suspension of capsules contains at least 80 wt.% the humidifier.

8. Suspension of capsules according to claim 1, in which the suspension of capsules has a water activity of less than 0,94 at 23°C.

9. Suspension of capsules according to claim 1, in which the humectant is sorbitol, glycerol or mixtures thereof; suspension contains from 1 to 50 wt.% water; and the rate of leakage of the contents of the capsules is less than 1E-9 M/s at room temperature.

10. Suspension of capsules according to claim 9, in which the capsule obtained by koatservatsii contains flavoring.

11. The way to reduce leakage of the contents of the capsules obtained by koatservatsii, including the storage, ENISA least one capsule obtained by koatservatsii, suspension of capsules containing at least 20 wt.% the humidifier
the humidifier is at least one humectant selected from sorbitol, glycerol, polyethylene glycol, propylene glycol, xylitol, erythrite or betaine.

12. The method according to claim 11, in which the humidifier is a sorbitol.

13. The method according to claim 11, in which the humidifier is a glycerin.

14. The method according to claim 11, in which the humectant is at least one humidifier from polyethylene glycol, propylene glycol, erythrite or betaine.

15. The method according to any of § § 11-14, in which the suspension of capsules contains at least 40 wt.% the humidifier.

16. The method according to item 15, in which the suspension of capsules contains at least 65 wt.% the humidifier.

17. The method according to clause 16, in which the suspension of capsules contains at least 80 wt.% the humidifier.

18. The method according to claim 11, in which the suspension of capsules has a water activity of less than 0,94 at 23°C.

19. The method according to claim 11, in which the suspension capsules added to the composition for cleaning teeth.

20. The method according to claim 19, in which the capsules obtained by koatservatsii add in means for cleaning the teeth in the amount of from 0.1 to 10 wt.%.

21. The method according to claim 19, in which the capsules obtained by koatservatsii add in tool is La brushing your teeth in the amount of 1 wt.%.



 

Same patents:

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry and represents a method for preparing a soft tissue filler composition, involving the stages as follows: preparing a HA (hyaluronic acid) ingredient cross-linked with at least one cross-linking agent specified in a group of 1,4-butanediol diglycidyl ether (BDDE), 1,4-bis(2.3-epoxypropoxy)butane, 1,4-bisglycidyl dioxybutane. 1,2-bis(2,3-epoxypropoxy)ethylene and 1-(2,3-epoxypropyl)-2,3 epoxycyclohexane; reducing pH of the above HA ingredient to more than approximately 7.2; and adding the solution containing lidocaine to the above HA ingredient having reduced pH as specified above to prepare the above soft tissue filler composition.

EFFECT: invention provides better stability and cohesion.

12 cl, 5 ex, 3 tbl, 9 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to oral hygiene and personal hygiene compositions, and more specifically to compositions comprising a film immersed into a carrier, wherein the film contains a relatively high concentration of a zinc compound. According to the invention, the oral hygiene composition comprises the film immersed into the carrier wherein the zinc compound is found in the amount from approximately 35 wt % to approximately 60 wt %.

EFFECT: increase in the solid content in the film enhances the active compound delivery per a unit area that is important to achieve the highest delivery efficiency.

23 cl, 2 dwg, 14 tbl, 8 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to whitening tooth pastes, adducts therefor, and methods for preparing them. The adduct applicable for preparing a whitening formulation is prepared by mixing raw materials comprising peroxide, urea and an alkali metal polyphosphate in aqueous solution in the environment of temperature and/or pressure and/or agitation effective to prepare a solution of raw materials. The relation of (alkali metal polyphosphate) to (peroxide) in the aqueous solution of the adduct is matched with the relation of (anhydrous alkali metal polyphosphate) to (hydrogen peroxide 35 wt/wt % of the concentration) falling within the range of 0.05:1 to 0.5:1, and the adduct has pH in the aqueous solution that increases at least by 1.0 after ten introductions of the solution.

EFFECT: preparing the dental whitening formulation wherein the adduct is found in the aqueous environment, comprises a drug preparation and/or the adduct has pH in the aqueous solution that increases by at least 1,0 after ten introductions of the solution (and hence, in situ in the mouth when in use) that provides the excellent whitening properties thought to be ensured by the release of additional active peroxide ions onto the teeth when in use.

15 cl, 4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to dentistry, namely to a nonabrasive tooth paste. The presented nonabrasive tooth paste contains the initial ingredients as follows: papain, sphagnum extract, polymethylvinylether alcohol - maleic acid copolymer sodium calcium salt, N-cocoyl ethyl arginate D,L-pyrrolidone carboxylate and sodium fluoride, and sodium carboxymethylcellulose, an emulsifier, a preserving agent, a flavour, 70% sorbitol and demineralised water in the following proportions.

EFFECT: paste provides effective oral cleansing, plaque removal, destruction of pathogenic flora, remineralisation of the tooth enamel and reduction of the oral inflammation.

11 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to dentistry, namely to oral care products. The presented tooth paste has the following composition of the initial ingredients used for preparing the same: Streptococcus pyogenes group A, Enterococcus faecium, Enterococcus faecalis, Streptococcus sanguis, Staphylococcus aureus subsp. aureus, Klebsiella pneumoniae subsp. pneumoniae, Corynebacterium pseudodiphtheriticum, Fusobacterium nucleatum subsp. nucleatum, Candida albicans, Lactobacillus acidophilius, Lactobacillus fermentum, Lactobacillus helveticus, Lactobacillus delbrueckii subsp. Lactus bacterial lysates. enzymes, lysozyme and papain, and an abrasive ingredient, a moisturiser, a hydrocolloid, a surfactant, sodium fluoride, tetrapotassium pyrophosphate, a preserving agent, a flavour and water in certain proportions. The tooth paste possesses manifested cleansing, anti-inflammatory and haemostatic action.

EFFECT: using the presented tooth paste enables activating phagocytosis, increasing saliva lysozyme, promoting an increase of the immune competent cell count.

9 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions refers to dental whitening compositions in the form of a liquid crystal or micro-emulsion and methods for using them. The composition contains a dental whitening agent in the amount wherein it is effective for dental whitening, a hydrophilic phase containing water, a hydrophobic phase containing oil, a surfactant specified in a group consisting of anionic, nonionic, amphoteric and zwitterionic surfactants, and a water-soluble co-solvent having a Hildebrand solubility parameter more than 12 (cal/cm3)1/2; the composition contains no thickening agent specified in a group consisting of synthetic resin, natural resin and synthetic resin. The formulation of the composition provides its physical and chemical stability, and also the effectiveness of dental whitening.

EFFECT: method for dental whitening involves applying the above liquid crystal or micro-emulsion composition onto the teeth for a period of time and under conditions effective for dental whitening.

20 cl, 7 tbl

FIELD: biotechnology.

SUBSTANCE: means comprises at least one phenolic compound from the group of derivatives of cinnamic acid or a mixture of such compounds, and a nonionogenic surfactant or a mixture of such substances in an amount of not less than 75% by weight.

EFFECT: invention enables to obtain beauty products, biologically active additives and food products on the basis of the described means and to use them to stimulate the reparative processes in a cell and to reduce the side effects of aggressive cosmetic procedures.

30 cl, 7 dwg, 3 tbl, 38 ex

Hygienic handwash // 2495658

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to chemical-pharmaceutical and cosmetic industry and represents a hygienic handwash, preferentially before using contact lenses. The hygienic handwash contains ethanol, glycerol, 1,2-propylene glycol, Pherol A, Aloe Vera extract, a flavour and water; as an antibacterial additive, the product contains polyhexamethylene biguanidine hydrochloride, while a moisturising supplement - KM-25 (water/propylene glycol extract of glucomannan) in the following proportions, wt %: Rectified ethanol 56.0-65.0; Glycerol 0.6-2.0; 1,2-propylene glycol 0.7-1.2; KM-25 (water/propylene glycol extract of glucomannan) 0.009-0.012: Pherol A 0.009-0.015; Aloe Vera extract 0.008-0.02; Flvour 0.05-0.07; Polyhexamethylene biguanidine hydrochloride 0.1-0.5; Water - up to 100%.

EFFECT: invention provides developing a product for effective hand protection and cleansing.

2 cl, 1 tbl

FIELD: medicine.

SUBSTANCE: invention refers to a new method for preparing an antiperspirant active compound having SEC chromatogram showing high SEC peak 4 intensity. The method involves heating an aqueous solution containing an aluminium salt having a molar ratio of aluminium to chlorine of 0.3:1 to 3:1, optionally with a buffer substance at temperature 50°C to 100°C in a backflow condenser tank for 1 hour to 6 hours to prepare an aluminium salt solution, adding an aqueous solution of sodium hydroxide for preparing the aluminium salt solution having the molar ratio of OH:Al 2:1 to 2.6:1 so that to prepare the aluminium salt solution with adjusted pH, having pH 2 to 5, providing calcium ions and adding optionally an aqueous solution containing zirconium to the aluminium salt solution with adjusted pH so that to prepare the aluminium and zirconium salt solution having the molar ratio of aluminium and zirconium 5:1 to 10:1. When the calcium base is used, the weight ratio of sodium hydroxide to the calcium base falls within the range of more than 0 to 20, or when a calcium ion source represents a salt, then the weight ratio of sodium hydroxide to the calcium ions falls within the range of more than 0 to 11.

EFFECT: method enables simplifying the stage of purification of the prepared antiperspirant product.

22 cl, 5 ex

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing a mixture of quaternised ammonium ester compounds which can be used as a softening component in fabric softening compositions. The method involves (i) reacting triethanolamine with an alkylating agent in conditions suitable for formation of a compound of formula , (ii) reacting said compound with a carboxylic acid in conditions suitable for formation of a compound of formula: . In the given formulae, R1 is a C1-C4 alkyl group; R2 is a C12-C22 alkyl group; X- is a counterion; j ranges from 0 to (2-k), and k equals 1 or 2. , where R1 is a C1-C4 alkyl group; R2 is a C12-C22 alkyl group; R3 is a C1-C4 ester or a halogen; X- is a counterion; j equals 0 or 1, and k equals 1 or 2.

EFFECT: obtaining a mixture of quaternised ammonium ester compounds which can be used as a softening component in fabric softening compositions.

7 cl, 1 tbl, 4 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to iron-enriched food product, which contains iron source in form of solid particles, where particles include core, containing iron alginate, and external layer, which contains calcium alginate, where particles are obtained by method which includes the following stages: (i) formation of core, which contains iron alginate, by contact of bioavailable water-soluble salt of iron and one water-soluble alginate salt, (ii) contact of core with water solution of calcium salt, in concentration, which constitutes from 0.025 M to concentration of lower than solution saturation point, and (iii) separation of obtained solid product. Iron-enriched food product is applied for prevention and treatment of iron deficiency conditions of people.

EFFECT: solid particles are applicable for enrichment of food products with iron and is characterised by improved load ability, as well as possesses good stability under standard storage and application conditions.

11 cl, 9 dwg, 13 tbl, 16 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine and pharmaceutical industry, particularly to creating a pharmaceutical composition of a submicron emulsion for parenteral administration, having anticonvulsant activity. The composition contains 5-carbamoyl-5H-dibenz-(b,f)-azepine, and additionally it contains soya been oil and sodium deoxycholate in the following proportions, wt %: 5-carbamoyl-5H-dibenz-(b,f)-azepine - 18.5-23.2, soya been oil - 2.1-2.3, sodium deoxycholate - 74.5-79.4. The composition has an average size of the deagglomerated microparticles of 108-132 nm.

EFFECT: composition enables the intravenous intraperitoneal administration of a low therapeutic dose with a high efficacy of the preparation, and reduction of dose-dependent adverse reactions, and extends the range of such preparations.

4 ex, 3 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical-pharmaceutical industry and represents microspheres for treating schizophrenia, having a nucleus/coating structure and a spherical shape wherein the nucleus contains ariliprazol in the solid state, and the coating covers the entire surface or most of the nucleus and contains a biodegradable polymer.

EFFECT: invention provides producing the microspheres of ariliprazol characterised by the high content and sustained release of the active substance, and preparing an injectable aqueous suspension of the above microspheres.

17 cl, 18 ex, 14 dwg

FIELD: nanotechnology.

SUBSTANCE: invention relates to the use of nanoparticles for prevention and/or treatment of cancerous diseases, when the nanoparticles are injected with anti-cancer therapeutic agent, and the nanoparticles and anti-cancer agent are simultaneously present in the patient's body. The nanoparticles are free from binding with the anti-cancer medicinal product and have a coating which contains polycondensated aminosilanes.

EFFECT: simultaneous presence of nanoparticles and the anti-cancer therapeutic agent in the body of patients enables to increase the activity of the said anti-cancer agent with simultaneous reduction of the side effects.

12 cl, 1 tbl, 13 dwg, 196 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine. A biocidal capsule for treating and diagnosing in vagina to be used in the biocidal preparation wherein at least one active ingredient is encapsulated with a wall insoluble or minimally soluble in an aqueous environment within the pH range lower than a threshold pH value, but soluble within the pH range higher than a threshold pH value wherein the threshold pH value is found between 4.6 to 6.0 and at least one of the walls and the content contains a tracer substance suitable for colour-coded indication. A tampon contains the biocidal preparation which in case of a vaginal tampon comprises a hygroscopic cylinder (1) preferentially swelling in a cross section under action of fluid, having a longer back flange (2) on an inner end inserted to a posterior vaginal vault, and a peritoneal flange (3) shorter than the back flange; and in between, there is a saddle (4) receiving a vaginal portion of neck of uterus.

EFFECT: invention provides using the preparation for medical and hygienic purposes, preferentially for elimination of pathogens of body surface, body openings, open and closed body cavities.

13 cl, 1 dwg, 1 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of medicine, namely to pharmaceutical industry and deals with disulfiram preparations. Medical form of disulfiram with prolonged action contains, at least, one microsphere from disulfiram, covered with first stabilising nanosize coating from neutral polysaccharides or gelatin, enclosed in second, spatially linked coating in form of microcapsule from neutral polysaccharides. Invention also deals with method of obtaining medical form of disulfiram with prolonged action.

EFFECT: application of claimed inventions ensures durative effect of prolonged action of disulfiram, stabile kinetics of drug release into tissues, sparing procedure of drug introduction and excludes possibility of its independent removal.

7 cl, 9 ex, 3 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, particularly to a medicine for treating depression. The oral medicine for treating depression prepared from a jujuba extract containing jujube cyclic adenosine monophosphate (jujuba cAMP) and an additional ingredient taken from a group consisting of a pharmaceutically acceptable carrier, an additive, an adjuvant and combination thereof. A method for preparing jujube cyclic adenosine monophosphate (jujuba cAMP) taken as an ingredient of the medicine for treating depression, involving the stages: (a) jujube extraction in water and alcohol to produce a primary extract, (b) primary extract purification to produce a secondary extract wherein the jujuba cAMP concentration in the secondary extract is higher than that in the primary extract wherein the stage (b) is performed by jujuba cAMP chromatography of the primary extract with the use of macroporous resins bound with an aldehyde group.

EFFECT: medicine is effective for treating depression, has no side effects.

16 cl, 7 dwg, 2 tbl, 9 ex

FIELD: medicine.

SUBSTANCE: group of inventions relates to compositions for oral cavity care, containing mucoadhesive polymers, and to their application for reducing symptoms associated with xerotomia. Claimed compositions contain cation-sensitive mucoadhesive polymer; and cation-releasing compound; where cation-releasing compound is incapsulated into degradable capsule. Examples of mucoadhesive cation-sensitive polymer materials include gellan gum and carageenan. Cation-releasing compounds include salts, such as calcium salts, sodium salts, salts of metals, preferably calcium chloride. Materials, applied for incapsulation of cation-releasing compounds include silicon, copolymer of lactic and glycolic acids (PLGA), alkylcellulose polymer. Composition for oral cavity care can be made, for instance, in form of liquid for mouthwash, spray for oral cavity care or toothpaste.

EFFECT: claimed compositions can be used for reduction and/or prevention of "dry mouth".

12 cl

FIELD: medicine, pharmaceutics.

SUBSTANCE: declared invention refers to chemical-pharmaceutical industry, and concerns new, taste-masking powders specified in a group consisting of biologically active substances for treating, relieving and preventing diseases in humans and animals, with average particle diameter d50 1 to 40 mcm and coating thickness 1 to less than 20 mcm of a hydrophobic coating material containing 50 to 90 wt % (relative to total powdered solid substance and coating material) with the hydrophobic coating material being wax of fusion temperature within 30 to 180°C, resin, polymethacrylate or its copolymer for inhalation or oral administration.

EFFECT: what is offered is a simple method for preparing and applying them for introducing the biologically active substances.

10 cl, 3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, particularly intraocular drug delivery systems. The system contains a number of microsphres of average diameter within 8 micron to 14 micron, an aqueous carrier for microspheres where the microspheres consist of: brimonidine, where brimonidine makes approximately 0.5 wt % to approximately 15 wt % of the microspheres, and one or more biodegradable polymers representing polymer poly(D,L)lactides with inherent viscosity 0.4 dl/g to 0.8 dl/g where PMC polymer makes 85 wt % to 99.5 wt % of the microspheres, and where the drug delivery system can be injected in an intraocular region through a needle of a syringe calibre 20-26, and the microspheres can release approximately 0.5 mcg/day to approximately 20 mcg/day of brimonidine within a period of time approximately 10 days to approximately 100 days to provide treating eye conditions. The intraocular region represents a subtenon space, a subconjunctival or retrobulbar region.

EFFECT: invention provides release of the therapeutic agent in a therapeutically effective amount for a period of 10 days to one year.

4 cl, 13 tbl, 6 dwg, 7 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine and chemical-pharmaceutical industry, namely to using ipidacrine as an agent for treating disturbed potency.

EFFECT: pharmaceutical composition of ipidacrine represents a tablet, including a prolonged action tablet, or a solid gel capsule.

4 cl, 4 ex, 3 dwg

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