Method of forming multidimensional image of cardiovascular system state and its visualisation

FIELD: medicine.

SUBSTANCE: invention relates to medicine. In method realisation current values of each of parameters of clinical data characterising current state of cardiovascular system are measured and fixed. Results of assessment of values of clinical data parameters are transformed. Results of assessment of current values of each parameter of clinical data are fixed depending on time of performed measurements. Results of transformation of assessment of current values of each parameter of clinical data are visualised on plane, coinciding with plane of displaying multicolour screen of videomonitor. Information about dynamics of cardiovascular system state is obtained. Also performed is digitisation and weighting of fixed instant values of each parameter of clinical data in physical values. Three-dimensional image of cardiovascular system state AN(t) is created in form of totality of geometrical places of points in N-dimensional space of cardiovascular system states, with coordinates of each point of N-dimensional space of cardiovascular system states being determined by totality of non-invasively and invasively measured in physical values digitised instant values of various clinical data, which characterise current state of cardiovascular system. Two-dimensional images of cardiovascular system states A2(t) are formed in form of projections of formed AN(t) on plane, coinciding with plane of displaying multicolour screen of videomonitor. Coordinates in 2-dimensional state of cardiovascular system states of each point of formed A2(t) are memorised. Virtual three-dimensional models of various nosologic forms of cardiovascular system diseases Bi are built in form of totality of M-geometrical places of points in N-dimensional space of cardiovascular system state, where i=1; 2; 3;…M is the number of displayed diseases of cardiovascular system. Coordinates of each point of each of B are determined by totality of values of various clinical data in physical values, describing characteristic clinical-morphological picture of corresponding disease and degree of CVS pathology manifestation, respectively. Coordinates in N-dimensional space of cardiovascular system state of all points of three-dimensional images Bi are memorised. Two-dimensional models of various nosologic forms of cardiovascular system diseases B2i are formed in form of projections, formed by B2i on plane, coinciding with plane of displaying multicolout screen of videomonitor. Coordinates in 2-dimensional space of cardiovascular system state of all points formed by B2i are memorised. Formed B2i are visualised on screen of multicolour videomonitor in such a way that colour of each point B2i in visible ranges of wavelengths Δλr, Δλo, Δλy, Δλg, Δλb…Δλ,m corresponds to certain type of disease, and degree of pathology is characterised by value, inversely proportional to wavelength of respective range. Visualisation on screen of multicolour videomonitor of successively formed in time values A2(t) is also performed, with each previous value A2(t) being connected by means of straight lines with their following values, and colour of A2(t) and connecting straight lines is formed by addition of red (Δλr), green (Δλg) and blue (Δλb) colours with similar amplitude proportion. Check of satisfaction of set of conditions A2(t) ⊂ B2i is carried out. Decision about cardiovascular system disease is taken in case of satisfaction of a condition from set A2(t) ⊂ B2i. Ambiguity of taking decision about cardiovascular system disease is excluded if mutual intersections B2i are present, when instant value A2(t) simultaneously belongs to two and more B2i, by formation on screen of multicolour videomonitor of each of new images of state A 2 k ( t ) and non-intersecting images of diseases в 2 i k by respective k transmissions of origin of coordinates of N-dimensional space of cardiovascular system state into selected by cardiologist points on plane of multicolour screen of videomonitor and carrying out procedure of projecting A(t) and Bi on plane coinciding with plane of displaying multicolour screen of videomonitor and after each of k transmissions of origin of coordinates of N-dimensional space of cardiovascular system state, where k=1; 2; 3;…j. Formed A 2 k ( t ) and в 2 i k are visualised on screen of multicolour videomonitor. procedure of A 2 k ( t ) and в 2 i k formation is stopped when condition, when A 2 k ( t ) belongs only to one в 2 i k is satisfied. Decision about absence of disease is taken if condition A2(t) ⊄ B2i is satisfied. Assessment of dynamics of change of cardiovascular system state is performed by results of analysis of preliminarily determined values of quantities Δτ=A2(t1)-A2(t2) and d Δ τ d τ for specified time interval, where t1; t2 are moments of time of beginning and end of specified time interval respectively.

EFFECT: invention makes it possible to simplify process of operative analysis of clinical data by set of measured clinical signs and avoid mistakes in generation of medical control decision for diagnosing.

5 dwg

 

The invention relates to medicine and medical technology and can be used in systems analysis and control, clinical (laboratory) data, including by computer Express-diagnostics for classification and prediction, monitoring analysis and monitoring of clinical data when diagnosing the condition of a living organism.

A method of obtaining a tomographic image of the body and electrical impedance tomography [1], providing diagnosis bodies with time-varying conductivity. The method is based on measuring the differences of potentials in time and provides the image reconstruction of the spatial distribution of the measured parameter by normalizing the obtained conductivity values, based on the fact that the lowest and highest values of conductivity highlighted in different colors. The method does not allow to assess the dynamics of changes of state of a living organism according to a variety of measured parameters (clinical data).

Known methods of computer processing and image analysis are used to gain useful information about the content of the image, its properties [2].

There is a method of computer processing and image analysis in medical diagnosis of erythrocytopenia [3]. The method allows the determination (measurement) of pairs is m erythrocytes of different classes in human blood and the visual representation of the respective images to build a histogram of the distribution of erythrocytes by classes, which judge about the deviation of the result from the norm, which ensures the diagnosis of the health status of the person.

The considered methods are unsuitable for dynamic monitoring and analysis of the state of a living organism, not allow to take into account the background of the current state of a living organism, and are time-consuming and cumbersome.

Known methods for the clinical evaluation of laboratory data used to gain useful information for the diagnosis and monitoring of treatment on the basis of laboratory tests of blood and urine [4]. The methods allow for both one-time and dynamic monitoring and analysis of the condition of the human body.

A disadvantage of known methods is the large complexity, the complexity and bulkiness of carrying out dynamic analysis of laboratory data for many of the measured parameters.

The closest in technical essence is a method for the visual display and dynamic control of clinical data [5], which allows a dynamic analysis of clinical data on many of their values and providing information in the form of Cvetkovi matrix diagram.

The main disadvantages of the prototype are the need for the analysis of large amounts of abstract information in the form of information which include Cvetkovi matrix diagrams what causes error when setting cardiologist diagnosis. In addition, in the prototype there is no possibility to implement the process of automated diagnosis.

The required technical result consists in carrying out a logical sequence of actions for the registration and statistical processing of the current values of the clinical data and complex analysis to obtain a rapid assessment of values and character of the distribution of values of clinical data and their continuous updating; forming a multidimensional image of the cardiovascular system (CVS) in accordance with the recorded clinical data and its visual display; automated generation of diagnosis based on the analysis results generated multidimensional image of the state of CVS.

The required technical result is achieved by the fact that carry out the method of forming a multidimensional image of the state of the cardiovascular system, its visual display and dynamic control, including the measurement and record the current values of each of the indicators of clinical data describing the current status of the cardiovascular system, the conversion results of the assessment of values of clinical data, the fixation of the results of the evaluation of the current values of each on the of azaela clinical data, depending on the time of the measurements (time of measurement), the visual display of the results of the conversion estimate the current values of each indicator of clinical data on a plane coinciding with the plane of displaying color video monitor screen, information about the dynamics of the cardiovascular system. In addition carry out the digitization and the weight processing the recorded instantaneous values of each of the clinical data, construct a volumetric image of the state of the cardiovascular system - A2(t) in the form of a set of geometric locations of points in N-dimensional state space, with the coordinates of each point in N-dimensional space of States of the cardiovascular system is determined by the aggregate non-invasive and invasive measured in physical quantities of digitized instantaneous values of various clinical data describing the current status of the cardiovascular system, form two-dimensional images of conditions of the cardiovascular system - A2(t) in the form of projections formed of AN(t) on the plane coincident with the plane of displaying color video monitor screen, remember the coordinates in 2-dimensional space of States of the cardiovascular system of each dot formed And2(t); build virtual about the roadways to model different nosological forms of diseases of the cardiovascular system - Biin the form of a set of M-geometric locations of points in N-dimensional space of the cardiovascular system, where i=1; 2; 3; ...M - the number of diseases of the cardiovascular system, with the coordinates of each point of each of the Inidetermined by the set of values of various clinical data in physical quantities that describe the characteristic clinical and morphological picture of the relevant disease and the severity of pathology of the cardiovascular system, respectively, to remember the coordinates in N-dimensional space of the cardiovascular system of all points of volumetric images of the Biform a two-dimensional models of various nosological forms of diseases of the cardiovascular system - B2iin the form of projections formed Bion the plane coincident with the plane of displaying color video monitor screen, remember the coordinates in 2-dimensional space of the cardiovascular system of all points generated B2ithat visualize on the screen multicolor video display formed B2iin the form of a set of M-geometric locations of points in N-dimensional space of the cardiovascular system, the color of which, in the visible wavelengths Δλto, Δλo, ΔλW, ΔλC, ΔλG...ΔλMmeet the t of a particular disease, and the degree of pathology is characterized by a value inversely proportional to the wavelength of the corresponding range, where Δλtored, Δλaboutorange, ΔλWyellow, ΔλCgreen ΔλGblue color and so on, are also the visualization on the screen multicolor video display sequentially generated over time the value of A2(t), with each previous value of A2(t) connect direct their subsequent values, and color of A2(t) and connecting direct form by adding red (Δλto), green (ΔλC) and blue (ΔλGcolors with the same amplitude ratio tests perform many of the terms And2(t) ⊂ B2itake decision about the disease of the cardiovascular system when any of the conditions of many A2(t) ⊂ B2iexclude if there is a mutual intersections B2ithe ambiguity of the decision to disease of the cardiovascular system, when the instantaneous value of A2(t) simultaneously belongs to two or more B2idue to the formation of the multicolor screen of the video monitor of each of the new images of the state ofA2k(t)and neper is sekushihsya images diseases B2ikby appropriate k transfers the origin of the N-dimensional state space of the cardiovascular system in the selected cardiologist point in the plane multicolor screen of the video monitor and implement procedures for projecting AN(t) and Bion the plane coincident with the plane of displaying color video monitor screen and after each of the k transfers the origin of the N-dimensional state space of the cardiovascular system, where k=1; 2; 3; ...j, visualize on the screen multicolor video display formedA2k(t)andB2ikcease the procedure of formation ofA2k(t)andB2ikupon reaching conditions, whenA2k(t) will belong to only oneB2ikmake the decision about the absence of disease, if the condition A2(t) ⊄ B2icarry out assessment of the dynamics of CAS on the results of the analysis of predefined values Δτ=And2(t1)-A2(t2anddΔtdtfor the given time interval, where t1; t2- times of the beginning and end of a specified time interval, respectively;anddΔtdt- the partial derivative on time from Δτ.

The inventive method of forming a multi-dimensional image of the state of CVS, visual display and control of the dynamics of change differs from the prototype in that the measured clinical data shall build on the plane displaying multicolor screen virtual models of different nosological forms of diseases. CCC - B2ias M is the geometric locations of the points, and the coordinates of each point of each of the B 2idetermined by the set of values of various clinical data in physical quantities that describe the characteristic clinical and morphological picture of the relevant disease in SSA, respectively, while the color of each of the B2iin the visible wavelengths Δλto, Δλo, ΔλW, ΔλC, ΔλG...ΔλMcorresponding to a type of the disease, and the degree of pathology is characterized by a value inversely proportional to the wavelength of the corresponding range, where Δλtored, Δλoorange, ΔλWyellow, ΔλCgreen ΔλGblue color and so on, where M is the number of diseases CCC. In addition, sequentially in time form A2(t), with each previous value of A2(t) direct connect, followed by their values and determine the values of Δτ=And2(t1)-A2(t2anddΔtdtfor the given time interval, wheredΔtdt- the partial derivative on time from Δτthat allows you set the th diagnosis of the current state of CVS on the results of the analysis of the conditions (a 2(t) ⊄ B2iand A2(t) ⊂ B2i. In this case, the diagnosis of the current state of CVS is carried out through the development of a cardiologist signal proportional to the difference of the coordinates ofΔρ=A2(t)-B2i. The decision about a particular disease CCC shall, if Δρ=0. Additionally, based on the analysis of the received signal Δρyou can make a prediction of possible changes in the status of CCC, which reduces the number of errors cardiologist at carrying out of diagnostics of the state of CVS.

These differences allow to draw a conclusion on the conformity of the proposed solutions to the criterion "novelty".

In the scientific and patent literature is not found the solution with this set of distinctive features. Therefore, the proposed solution meets the criterion of "inventive step".

Method of forming multi-dimensional image of the status of CCC, as follows. Enter two state class CCC: healthy and unhealthy condition. Further unhealthy state of CVS divided into subclasses in compliance and with certain deviations of the current values of clinical data from the norm, describe the typical clinical and morphological picture of the relevant disease in SSA.

It is known that the assessment of the status of CCC persons on the basis of clinical findings is based on the solution of the inverse multivariate tasks cardiology. To solve such problems, usually associated with considerable difficulties, causing errors in diagnosis [5]. Consider reduction of various confounding factors on the quality of the solution of inverse problems of cardiology.

The invention is illustrated in the drawings,

where:

figure 1. L - display points defined in four-dimensional space, a plane multicolor display screen;

figure 2. S - display points defined in four-dimensional space, a plane multicolor display screen;

figure 3. The mutual position of two-dimensional images of diseases B2iafter k translation of the coordinate origin of the N-dimensional state space CCC;

figure 4. Changing the position of the localization pointA'2(t1)relativelyB'21and B'22after k+1 translation of the coordinate origin of the N-dimensional state space CCC;

figure 5 Dynamics of change (for the time interval Δt=t2-t1)A'2(t)on the plane multicolor display screen.

Let the state of the CCC is estimated by some finite set N of non-invasive and invasive digitized measured instantaneous values of various clinical data in physical quantities that can be represented as N-dimensional space state of CVS. In this N-dimensional space to build a virtual three-dimensional model of different nosological forms of diseases SSS - In, in the form of M - geometric locations of the points, where M is the number of diseases CCC; i=1; 2; 3... [6]. The coordinates of the points in each of the M - geometric locations can be represented as a set of specific instantaneous values of various clinical data describing the characteristic clinical and morphological picture of the relevant disease in SSA.

For further analysis of the state of CVS each point In each projecting onto the plane coinciding with the plane of displaying color video monitor screen, SLE is the result of that form two-dimensional models of various nosological forms of diseases CCC - B2ithat then visualize. The color of each of the B2iin the visible wavelengths Δλto, Δλo, ΔλW, ΔλC, ΔλG...ΔλMcorresponding to a type of the disease, and the degree of pathology is characterized by a value inversely proportional to the wavelength of the corresponding range, where Δλtored, Δλaboutorange, ΔλWyellow, ΔλCgreen ΔλGblue color and so on,

For projection of each point of N-dimensional state space CAS on a plane coinciding with the plane of displaying multi-color screen of the video monitor, the first form displaying N-dimensional coordinate system on the plane as follows: from a point, which is the origin of the build N vectors with an angle between adjacent vectorsπn. The projection of the points of volumetric images of diseases of the CCC of the N - dimensional state space CAS on a plane is carried out in two stages [7]:

Step 1. At this stage we find the direction of the vector in the plane {X';Y'}, coincident with the plane of displaying multi-color screen of the video monitor that are generated in the projection point of the N-dimensional state space of the CAS on the plane containing n is a principle coordinates of the given N-dimensional space (this stage is called the stage of formation of L - display).

Suppose we have an N-dimensional coordinate system(p0,p1,...,pn-1)wherepi- a single two-dimensional vector is the projection of the unit vector N-dimensional space on a two-dimensional plane, and a point z with coordinates (z1, z2, ..., zn)in N-dimensional space. Then the coordinates of the projection of a point z (z1, z2, ..., zn) on the plane {X';Y'}, coincident with the plane of displaying color video monitor screen are determined in accordance with a relation of the form:

zL(x',y')=i=1nzipi, (1)

where

zL(x', y') coordinates of the projection of a point z(z1,z2,...,zn) on the plane {X';Y'}:

(x', y') coordinates in the plane {X';Y'}.

Connecting the origin with the point zL(x', y')formed by the direction of the vectorzL.

Step 2. This stage is called the stage of formation of S-display and its essence consists in the following : at this stage, find the module of the vectorzL.

S - display point z with coordinates (z1, z2, ..., zn) there is a point zSwhich is the end of the vector, constructed from the beginning of the two-dimensional coordinate space to the point zS(xS, yS), whose length is the Euclidean distance from z to the origin in N-dimensional space of state CCC, and collinear to the vector built from the beginning of the two-dimensional coordinate space to the point zLcalculated in accordance with equation (1).

This Euclidean distance of the point zSdetermined in accordance with a relation of the form:

|zS|= (z1-c1)2+(z2-c2)2+...+(zn-cn)2,(2)

where (c1c2, ..., cn) - the origin of coordinates in N-dimensional space state of CVS.

In the implementation of the first and second stages, find the projection vectorzSand thus, the true coordinates of the corresponding point on the N-dimensional state space of the CAS on the plane {X';Y'}.

Let us illustrate the procedure of the above-described two-step process projection on the example of 4-dimensional space (N=4) and a given point in space.

For simplicity of analysis, but without losing the generality of the discussion, let us place the origin of the 4-dimensional space to a point with coordinates(0, 0, 0, 0), we illustrate the process of formation of L-display the points with coordinates (-1; 4; 2; 1.5) on the plane of the screen (figure 1).

In cislis the length of the vector zSin accordance with relation (2):

|zS|=(-1)2+42+22+1.52=4.8;

S - display this point is illustrated in figure 2.

In the projection of each point of each of the Bion the plane coincident with the plane of displaying color video monitor screen above method, forming a two-dimensional models of various nosological forms of diseases CCC - B2ithat then render.

Next is one of the known methods [8] digitization and weight handling fixed in physical terms instant. values of each indicator clinical data of the patient. Then build a volumetric image of the state CCC patient - AN(t) in the form of a set of geometric locations of points AN(t), where the coordinates of each of its points is determined by the aggregate non-invasive and invasive measured in physical quantities of digitized instantaneous values different to incesti data describing the current status of CCC patients in the N-dimensional space. Form two-dimensional images of conditions of CCC - A2(t) in the form of projections formed of AN(t) on the plane coincident with the plane of displaying color video monitor screen, where the coordinates of each point AN(ti) determine in accordance with the above-described method.

Next, perform the following set of conditions A2(t) ⊄ B2iand A2(ti) ⊂ B2iand make a decision about the absence of disease or the presence of the disease in SSA during execution of one or other of the terms And2(t) ⊄ B2iand A2(ti) ⊂ B2i. That is, depending on how specific is formed on a plane two-dimensional model B2iis the current point A2(ti), the cardiologist can conclude about the possible diseases of the patient at a given time.

But in an N-dimensional state space CAS volumetric images of diseases Bican be the same for a number of clinical data, this may be the imposition of a projected two-dimensional B2ieach other. This fact necessitates the inclusion in the process of diagnostics of CCC research procedures topology relative position of the two-dimensional B2iorder op is adelene collisions of their intersection.

Exclusion of ambiguous decision-making about the disease. CAS, when the instantaneous value of A2(t) can simultaneously belong to two or more B2iwhen their mutual intersection and hit this instantaneous values And2(t) in the region of intersection, carried out by forming new images of the state ofA2k(t)and disjoint two-dimensional models of different nosological forms of diseases SSS -B2ikby appropriate k transfers the origin of the N-dimensional state space of the CAS in the selected expert points on a plane multicolor screen, where k=1; 2; 3; ...j [9]. At each such transfer origin formA2k(t)andB2ikby projecting AN(t) and Bias described above, in the plane {X';Y'}, containing the new origin. After each of the k transfers the origin of the N-dimensional state space CAS and fo is the formation of A2k(t)andB2ikverify that requirementsA2k(t)B2ikorA2k(t)B2ik. Stop procedure of the study the topology of mutual arrangement of the B2iand the formation ofA2k(t)andB2ikwhen the condition is met whenA2k(t)will belong to any one ofB2ikor is just the condition A2(t)⊄ B 2i.

For example, figure 3 illustrates the topology of the mutual position on the plane {X',Y'} multicolor screen video display two-dimensional image of the CCC States, corresponding to the time t1- A2(t1) relative to the two virtual two-dimensional models nosological forms of diseases SSS - In21and In22when k is the translation of the coordinate origin of the N-dimensional state space CAS (see figure 3). Analysis of figure 3 shows that at time t1after k translation of the coordinate origin of the N-dimensional state space CAS cannot be uniquely determined disease CCC as As2(t1) falls in the region of intersection of B21and In22. To eliminate this ambiguity, the decision about the disease CCC, follow the procedure of k+1-th transfer coordinates in the selected expert point on the plane {X',Y'}, and then formed as described aboveA'2(t1),B'21andB'22. Topology relative position on umemulo image States CCC, the corresponding time t1-A'2(t1)on the two virtual two-dimensional models nosological forms of diseases SSS -B'21andB'22after k+1 translation of the coordinate origin of the N-dimensional state space CAS is illustrated in figure 4. Analysis of figure 4 shows that at time t1after k+1 translation of the coordinate origin of the N-dimensional state space CAS virtual two-dimensional model nosological forms of diseases SSS -B'21andB'22spatially completely separated, andA'2(t1)belongs only to theB' 22. This topology mutual position ofB'21,B'22andA'2(t1)lets put a definite diagnosis.

To assess the dynamics of changes in the status of CCC determine the values of Δτ=And2(t1)-A2(t2anddΔtdtfor the given time interval.

The obtained values of ΔτanddΔtdtand the results of periodic audits of the conditions A2(t) ⊄ B2iand A2(t) ⊂ B2iat a given time interval allows not only to assess the current state of CVS, but also to forecast changes this state, including the possibility of implementing this procedure is automatic. For example, figure 5 illustrates one possible topology changes of the mutual position ofA'2(t1)relativelyB'21;B'22(see figure 4) for the time interval Δt=t2-t1.

Figure 5 graphically presents the dynamics of the processes of state changes CCC appears as a change in the localization pointA'2(ti)where i=1; 2; 3; ..., characterizing the condition of a particular patient, relative to the formed two-dimensional models nosological forms of diseases SSS -B'21andB'22the time interval Δt=t2-t1.

Thus, FR is tively method allows you to obtain information about the status of the CCC in the form of a multidimensional image of this state, which logically intuitive and easy to use when using his cardiologist. This in turn will eliminate the need for a cardiologist analyze large amounts of abstract information in the form of, for example, information Cvetkovi matrix diagram and the associated error in diagnosis. Additionally, you receive the opportunity to realize the process of automated assessment CAS and forecast of its development.

Analysis of the results of the formation of multidimensional image of the state of SSA and its visual display, helps to make an accurate diagnosis of the patient, to detect hidden diseases. It is also important to note that this approach allows us to track the dynamics of the state CCC patient, based on the analysis of the behavior of the locus ofA'2(ti)on the screen, describing the diagnosed patient.

Thus, the proposed method of generating a multidimensional image of the status of CCC, its visual display and dynamic control can be considered as a new approach in medical diagnosis, providing for cardiologist informational support making medical decisions.

The object of the surveys and medical settings can be very different.

For conducting on-line (real measurements) control current values of clinical data is a very effective use of this method is the mode of observation or monitoring (on-line viewing of clinical data using the computer).

The application of the proposed method in medical practice will allow us to monitor and analyze patterns of diseases, consequently, may lead to improved diagnosis of diseases, and some warning of their development. The application of the proposed method can now be found widely distributed in clinics that use a technology called "tele-cardiology".

Sources of information

1. EN 2127075, AB 5/05, 10.03.1999.

2. Computer processing and image analysis. BYTE. Russia. The magazine for professionals. Izdat. The House Of Peter. 6/7 (22-23), June-July, 2000, p.54-57.

3. Computer processing and image analysis. BYTE. Russia. The magazine for professionals. Izdat. The House Of Peter. 6/7 (22-23), June-July, 2000, p.57-59.

4. Reference therapist. Volume 2. M: LLC Izdat. ACT. 1998. SCR-720.

5. EN 2195017, G06F 19/00, publ. 20.12.2002.

6. Korenev N.A. Principles and methods of designing interactive systems diagnosis and management of the human health-based polyfunctional models: Dis. Prof. technology. of Sciences, St. Petersburg, 1993. - 322 S.

7. Dovgal VM, P is rcov F.A., Classification and recognition of point images using visualization of multidimensional objects [Text] // proceedings of the Kursk state technical University. 2007. No. 4(21). P.78-80.

8. Foreheads G.S. Methods of processing different types of experimental data - Novosibirsk: Nauka, 1981. - 158 S.

9. Kochetkova I.A., the Use of geometric methods of pattern recognition for decision support physician diagnostician / IA Kochetkova // Mathematical methods in engineering and technologies - mmtt-23, [text]: Proc. of XXIII international. scient. Conf.: 12 TT 6. Section 7 / under the General editorship B.C. Balakirev. Belgorod: Belge. state technology. University, 2010. - S-157.

Method of forming multi-dimensional image of the state of the cardiovascular system and its visualization, consisting in measuring and fixing the current values of each of the indicators of clinical data describing the current status of the cardiovascular system, the conversion results of the assessment of values of clinical data, recording results of the evaluation of the current values of each indicator of clinical data, depending on the time of the measurements, the visual display of the results of the conversion estimate the current values of each indicator of clinical data on a plane coinciding with the plane of displaying color video monitor screen, gaining the information about the dynamics of the cardiovascular system, characterized in that carry out the digitization and the weight processing the recorded instantaneous values of each indicator of clinical data in physical terms, build a volumetric image of the state of the cardiovascular system - AN(1) in the form of a set of geometric locations of points in N-dimensional space of States of the cardiovascular system, and the coordinates of each point in N-dimensional space of States of the cardiovascular system is determined by the aggregate non-invasive and invasive measured in physical quantities of digitized instantaneous values of various clinical data describing the current status of the cardiovascular system, form two-dimensional images of conditions of the cardiovascular system - A2(t) in the form of projections formed of AN(t) on the plane coincident with the plane of displaying color video monitor screen, remember the coordinates in 2-dimensional space of States of the cardiovascular system of each dot formed A2(t); build a virtual three-dimensional model of different nosological forms of diseases of the cardiovascular system - Biin the form of a set of M - geometric locations of points in N-dimensional space of the cardiovascular system, where i=1; 2; 3; ...M - the number of diseases of the cardiovascular system, if e is ω-coordinates of each point of each of the In idetermined by the set of values of various clinical data in physical quantities that describe the characteristic clinical and morphological picture of the relevant disease and the severity of pathology CCC, respectively, to remember the coordinates in N-dimensional space of the cardiovascular system of all points of volumetric images of the Biform a two-dimensional models of various nosological forms of diseases of the cardiovascular system - B2iin the form of projections formed Bion the plane coincident with the plane of displaying color video monitor screen, remember the coordinates in 2-dimensional space of the cardiovascular system of all points generated B2ivisualize on the screen multicolor video display formed B2iso that the color of each point B2iin the visible wavelengths Δλto, Δλo, ΔλW, ΔλC, Δλg,...,Δλmcorresponding to a type of the disease, and the degree of pathology is characterized by a value inversely proportional to the wavelength of the corresponding range, where Δλtored, Δλaboutorange, ΔλWyellow, ΔλCgreen, Δλgblue, ..., Δλmperform the rendering on the screen multicolor VI is iomonitor sequentially generated time values And 2(t), with each previous value of A2(t) connect direct their subsequent values, and color And2(t) and connecting direct form by adding red (Δλto), green (ΔλC) and blue (Δλgcolors with the same amplitude ratio are checking multiple conditions A2(t) ⊂ B2itake decision about the disease of the cardiovascular system when any of the conditions of many And2(t) ⊂ B2iexclude if there is a mutual intersections B2ithe ambiguity of the decision to disease of the cardiovascular system, when the instantaneous value And2(t) simultaneously belongs to two or more B2idue to the formation of the multicolor screen of the video monitor of each of the new images of the state ofA2k(t)and not overlapping images diseasesin2ikby appropriate k transfers the origin of the N-dimensional state space of the cardiovascular system in the selected cardiologist point in the plane multicolor screen of the video monitor and implement procedures about what tiravanija A(t) and B ion the plane coincident with the plane of displaying color video monitor screen, and after each of the k transfers the origin of the N-dimensional state space of the cardiovascular system, where k=1; 2; 3; ...j, visualize on the screen multicolor video display formedA2k(t)andin2ikstop the procedure of formation ofA2k(t)andin2ikupon reaching conditions, whenA2k(t)will belong to only onein2ikmake the decision about the absence of disease, if the condition A2(t) ⊄ B2icarry out assessment of the dynamics of state changes of the cardiovascular system based on the analysis results preliminary what about the specific values of Δ τ=And2(t1)-A2(t2anddΔtdtfor the given time interval, where t1; t2- times of the beginning and end of a specified time interval, respectively;anddΔtdt- the partial derivative on time from Δτ.



 

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25 cl, 8 dwg

FIELD: information technologies.

SUBSTANCE: method to support decision-making based on instances includes a stage of calculation of remoteness from likeness between the input case of requesting and the set of instances for extraction of similar cases, using the set of standard criteria and their weights for assessment of likeness. Then, in accordance with the method, a user is provided with similar instances and a set of standard criteria and weights. And also an input is received from the user, including a variable weight for one of the set of standard criteria and/or one new criterion in addition to the set of standard criteria. Besides, the calculation of remoteness from likeness is varied with a new set of criteria and weights for extraction of instances similar from the point of view of the user. At the same time a new set of criteria and weights is generated on the basis of clustering on the basis of likeness for variation of calculation of the remoteness from likeness by means of start-up of a genetic learning logic.

EFFECT: creation of a basis system of input estimates of likeness for adaptation of actual value of likeness to similar users with another experience or other opinion.

11 cl, 3 dwg

FIELD: information technologies.

SUBSTANCE: under clinical conditions, when at any time there are several patients, there are central stations (10) of patient control, for instance, nursing units, for combination of the collected information relative to physiological parameters of patients. Data is displayed in several subwindows (22) of the display (18) of the control station (10). Due to certain limitations for dimensions of the display (18), it is often difficult to distinguish data displayed in subwindows (22), or even display all collected data. The user may expand any such subwindow (22) into a scale-variable subwindow (32), which provides for more functions than any other subwindow (22), without full coverage or adjustment of size of any other subwindow (22).

EFFECT: improved access to information.

12 cl, 6 dwg

FIELD: chemistry.

SUBSTANCE: method of operating a device for measuring an analyte, having a display, a user interface, a processor, memory and user interface buttons includes steps of: measuring the analyte in the body fluid of a user using the analyte measuring device; displaying a value representing the analyte; prompting the user to select an indicator for linking with the displayed value; and pressing one of the user interface buttons only once to select an indicator linked with the value of the analyte, and storing the selected indicator together with the displayed value in the memory of the device. The group of inventions also relates to a method of operating the measuring device, which additionally includes a step of ignoring activation of any of the user interface buttons except the selected button.

EFFECT: more intuitive and easier use of the device for measuring an analyte, eg a glucometer.

20 cl, 12 dwg

FIELD: information technology.

SUBSTANCE: method of extracting a plurality of data layers from a set (5) of data of medical images, wherein the method includes the following steps: a) displaying an indicator (10, 20) associated with the plurality of data layers; b) selecting the indicator (10, 20) based on user input; and c) extracting the plurality of data layers associated with the indicator when said indicator is selected; wherein the link between the indicator and the plurality of layers is based on segmentation of the set of data of medical images, wherein the indicator is an object obtained during segmentation of the set of data of medical images, and the plurality of data layers include object data, wherein the object data are contained in the plurality of layers.

EFFECT: reducing the amount of data transmission.

12 cl, 7 dwg

FIELD: physics.

SUBSTANCE: invention discloses a computer implemented method and system for conducting a geologic basin analysis in order to determine the accumulation of hydrocarbons in a subsurface region of interest. According to the disclosure, a basin analysis project is defined within a subsurface region. At least one basin analysis cycle is applied to the basin analysis project and the results of the basin analysis are integrated to generate basin analysis project results for the basin. The project results are used to optimise and manage the performance of technical tasks required to determine the accumulation of hydrocarbons in the subsurface region of interest.

EFFECT: high accuracy and information value of survey data.

20 cl, 26 dwg

FIELD: radio engineering, communications.

SUBSTANCE: device comprises P units of maximum signal separation, P units of activation function calculation and P groups of membership function values generation units.

EFFECT: increased accuracy of recognition when recognising objects with separate low or partially distorted areas.

1 dwg

FIELD: information technology.

SUBSTANCE: apparatus has a synchronisation unit 1, an integrated unit 2, a switch 3, units for controlling and linearising transfer characteristics of multichannel converters 4, counters for counting the number of times a fault detection subunit 5 is switched, a control unit 6, memory units 7 and 8. The output of the synchronisation unit is connected to the input of an interfacing unit, and a multidimensional sequence generator is in form of a multichannel device of a matrix structure with feedback, and the data output of the interfacing unit fully conforms to data connections, and its data output is connected to the input of the switch.

EFFECT: high accuracy of simulation by combining control of transfer characteristics and statistical estimation of the frequency index of the effect of the set of destabilising factors.

2 dwg

FIELD: medicine.

SUBSTANCE: ECG analysis system comprising: an input device for receiving an ECG enquiry from a patient, and a control system configured to extract the information relevant to the patient, to consolidate the received enquiry and the extracted information into an updated enquiry, and to send the updated enquiry to an ECG apparatus; the extracted information contains the previous ECG result selected from a variety of the previous ECGs with the use of the best-previous ECG algorithm. The method describes the system operation procedure.

EFFECT: higher accuracy and effectiveness of the automated ECG analysis providing more information to ECG specialists and transcriptionists.

13 cl, 2 dwg

FIELD: medicine.

SUBSTANCE: drug delivery system includes: a drug delivery point comprising at least one protected compartment configured to store the drugs, a controller responding to the status information on patient's admission to hospital and configured to: to prescribe at least one of these protected compartments for administering and protecting the drugs for the patient; to give a selective access to the drugs for patients in at least one protected compartment when the status information on patient's admission to hospital indicates that the patient is currently admitted, and to clock the access to retrieve the drugs for the patient in at least one protected compartment when the status information on patient's admission to hospital indicates that the patient is not currently admitted, wherein the controller is further configured to generate a notification to the pharmacy console to remove the drugs from at least one protected compartment prescribed to the patient once the patient is discharged from hospital.

EFFECT: patient-specific drug delivery.

15 cl, 8 dwg

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to pediatrics and can be used in neurology, medical psychology and psychiatry. Clinical examination of children is carried out by complaints, anamnestic information and data of physical examination. Assessed are: symptoms of vegetative manifestations at the moment of examination and peculiarities of sensomotor reactions: weight and length of body at birth, gestation age, response to stimulation in children of first year of life, sleep in children of first year of life, EEG in children of early age, parasomnia, enuresis, meteosensitivity, headaches, vessel lability, vestibulopathy, peculiarities of motor sphere, feeding behaviour, skin manifestations, course of infectious and somatic diseases, menstrual disorders in adolescent girls, brain ultrasound examination. Connection of said disorders with predominant dysfunction of right or left brain hemispheres is determined.

EFFECT: method makes it possible to increase reliability of diagnostics, which is achieved due to taking into account vegetative reactions and disorders in child of first year of life.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to experimental medicine. After 7 weeks of toxicant impact, stimulating electroneuromyography is performed; amplitude and latent period of M-response are registered. Canonical value (Cv) is calculated taking into account constant - 5.95, discriminatory factors 0.98 and -1.14, as well as numerical values of examination results. If Cv is larger than 5.95, conclusion about absence of signs of mercuric chloride impact on peripheral nerves is made, if Cv is smaller or equals 5.95, affection of peripheral nerves caused by impact of mercuric chloride, is diagnosed.

EFFECT: method extends arsenal of means for diagnostics of affection of peripheral nerves in laboratory animals in early post-contact period of exposure to mercuric chloride.

1 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, rehabilitation, in particular, of patients with hand paresis. Patient's hand is placed and fixed in device in form of sensor glove; sensitive and current-conducting elements are placed and fixed relative to device. Device is switched to computer; computer game programme is downloaded and started. Sensor glove is used as manipulator in such a way that patients makes active movements of flexion-extension of hand and fingers, providing in this way corresponding specified movements of computer game object on monitor screen and causing by this activation of sensitive elements and their registration in computer. Course of correction sessions constitutes 28-30, 1-2 times per day 5 days per week. Duration of one session is determined by severity of patient's general state and constitutes in average 30-40 minutes.

EFFECT: method ensures extension of functional possibilities, effective rehabilitation in case of motor disorders due to objective computer analysis of sensomotor processes with smaller time consumption, as well as possibility of rehabilitation of motor function of hand with participation of patient with impaired nervous system in rehabilitation process.

2 cl, 1 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to orthopedics. Before operation examination of biceps of injured extremity is carried out in state of its maximal voluntary tension and value of mean frequency of bioelectric activity of musculus biceps brachii is determined. If value of mean frequency of musculus biceps brachii constitutes less than 123±12.31 Hz, development of endoprosthesis instability in remote terms after operation is predicted.

EFFECT: method makes it possible to identify patients with risk of development of shoulder joint prosthesis instability in remote terms after operation.

1 tbl

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to oncologic neurosurgery, neurology, psychiatry and functional diagnostics. Electroencephalographic examination is carried out. Level of coherent connection between pole-frontal and anterior temporal regions of cerebral cortex on the right is calculated in beta-range. If said parameter is higher than 0.52, Korsakoff's syndrome is diagnosed.

EFFECT: method makes it possible to increase reliability of Korsakoff's syndrome diagnostics.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to drug-free methods for activation of the cerebral verbal functions. Cerebral signals are recorded. Their duration is measured. A related verbal stimulus is established for the derived wave duration and has an effect on the patient. That is followed by measuring the duration of the next current wave through a time interval not less than the maximum duration of the used verbal stimuli, and the patient is exposed to the verbal stimulus corresponding to the current wave. According to the other version of implementing the method, the duration of the current wave is measured, and the corresponding verbal and contextually harmonised visual stimuli are set for the above duration. The patient is exposed thereto. That is followed by measuring the duration of the regular current wave through a time interval not less than the maximum duration of the used verbal stimuli, and the patient is exposed to the verbal and contextually harmonised visual stimuli corresponding to the current wave.

EFFECT: invention enables acceleration the process of verbal development in children.

1 dwg, 3 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly herniology. The patient is suggested to perform a first static load on the abdominal muscles whereat total electric activity of the abdominal rectus muscle (TEA-1) is recorded, and a dynamic load on the abdominal muscles, and a second static load on the abdominal muscles. The study involves recording total electric activity of the abdominal muscles - TEA-2. And a fatigue level (FL) of the abdominal muscles is calculated by formula: FL=TEA2TEA1, If the FL falls within the range of 0.9-2.4 units, the tension repair of the hernia defect. The FL exceeding 2.4 units requires performing the tension-free repair of the hernia defect with using mesh implants.

EFFECT: improved effectiveness of the method.

2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, diagnostics, may be used in sports and rehabilitation therapy. When estimating a load strength whereat the muscular work power supply for a linear increasing load test starts involving the active anaerobic processes, the moment of aerobic-anaerobic transition (MAAT) is shown by a maximum position of a time history curve of the hemoglobin concentration in the working muscle measured by IR-spectroscopy to intensity or a high-frequency component of the surface electromyogram of the above muscle.

EFFECT: method provides specifying the MAAT with no near-limit loads used, with enabled MAAT estimation in separate relatively lightweight muscles which when contracted cause no visible changes of the systemic physiological values, simplicity and non-invasiveness of the procedure.

3 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, specifically surgery and functional diagnostics. The supine heart rate is recorded and represents a baseline test, while the standing heart rate measured is an orthostatic test for 30 sec. The regulatory system activity index (RSAI) is described in points 1 to 10. An increase of this value relates to the deteriorating body adaptive possibilities; the RSAI value of 3-10 points enables predicting the postoperative wound complications.

EFFECT: method enables predicting the postoperative complications following the replacing hernia repair for postoperative hernias.

4 dwg, 3 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly paediatrics. The rest heart rate is metered in infants. The heart rate variability is analysed. The values in the 1-2-month-old infants 1001 < total spectrum power <1500 ms2 and 701< tension index <1000 standard units, in the 3-4-month-old infants 1501< total spectrum power <2000 ms2 and 501< tension index <700 standard units, in the 5-6-month-old infants 2001< total spectrum power <2500 ms2 and 401< tension index <500 standard units, in the 7-12-month-old infants 2501< total spectrum power <3000 ms2 and 101< tension index <150 standard units, reflect the optimal functions of the regulatory systems. If total spectrum power occurs to be greater than the optimal values, and tension index is less than the optimal values, an autonomous type of the vegetative heart rate regulation that testifies to the low adaptive capabilities. Total spectrum power less than the optimal values and tension index more than the optimal values shows manifested tension of the vegetative heart rate regulation that testifies to the supertension of the regulatory mechanisms.

EFFECT: method enables typing the vegetative regulation in the infants taking into account the age peculiarities, assessing the adaptive processes both in healthy children, and in deviant children, specifying the individual therapy and assessing the effectiveness of the expected rehabilitation measures.

4 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to pediatrics and can be used in neurology, medical psychology and psychiatry. Clinical examination of children is carried out by complaints, anamnestic information and data of physical examination. Assessed are: symptoms of vegetative manifestations at the moment of examination and peculiarities of sensomotor reactions: weight and length of body at birth, gestation age, response to stimulation in children of first year of life, sleep in children of first year of life, EEG in children of early age, parasomnia, enuresis, meteosensitivity, headaches, vessel lability, vestibulopathy, peculiarities of motor sphere, feeding behaviour, skin manifestations, course of infectious and somatic diseases, menstrual disorders in adolescent girls, brain ultrasound examination. Connection of said disorders with predominant dysfunction of right or left brain hemispheres is determined.

EFFECT: method makes it possible to increase reliability of diagnostics, which is achieved due to taking into account vegetative reactions and disorders in child of first year of life.

1 tbl, 2 ex

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