Method of treating acne
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutical industry, namely a method of treating acne. The method of treating acne by prescribing line seed oil 10 ml 2 times a day, sodium selenite 90 mcg 1 time a day, tocopherol acetate 100 mg 2 times a day for 1 month.
EFFECT: method of treating acne is effective and enables reducing the length of treatment.
The invention relates to the field of medicine and industry biologically active food supplements containing vitamins, minerals and herbs, and can be used in dermatology mainly for the treatment of patients with acne (acne).
It is known tool - hydrosulphate graphically complex and method for the treatment of patients with various inflammatory skin diseases, including such as various forms of acne.
Known means contains a hydrosulfate gravitationaly complex obtained by treating graphite with concentrated sulfuric acid in a ratio of 1:1 in the presence of concentrated nitric acid, which dissolved selenium at a rate of 1 g of selenium 50 ml of nitric acid, and a filler, such as vaseline, having colloidal properties, with volume ratios of filler and complex 25:1-12,5:1.
The known method is characterized by the fact that the affected skin is applied above the tool, if slightly severe inflammation use the tool in the treatment of patients with ugrevidnye form of skin inflammation with the formation of keloid scars - in the ratio of 12.5:1, and the product is applied on the affected skin for 2 hours in a day, the course of treatment up to six months (see the description of the invention to the patent of Russian Federation №2182822, IPC A61 is 9/06, 33/04, 33/44, 31/095, OR 17/02, publication 27.05.2002).
A disadvantage of the known tool is the toxic action of acid, and a long treatment period (up to 6 months).
The disadvantage of this method is the unsuitability of the means used for long-term storage and transportation, as well as short therapeutic effect.
The known method of acne treatment by prescription, including bromkriptin 5-7,5 mg per day orally and α-thyroxine in 25-75 mg per day orally for the entire course of treatment, and also antithrombin 2000 mg per week inside and vitamin E intramuscularly 1 ml for 10 days (see the description of the invention to the patent of Russian Federation №2148994, IPC AC 31/00, AR 5/26, publication 20.05.2000), is the prototype.
The disadvantage of this method is the lack of unification of methods, resulting in a large number of side effects bromocriptine, such as nausea, vomiting, dizziness; rarely orthostatic hypotension. Myocardial infarction, stroke. Constipation, drowsiness, headache, agitation, hallucinations, psychosis, dyskinesia, decreased visual acuity, dry mouth (dental caries, periodontal diseases, aromantics, discomfort, nasal congestion, allergic reactions, skin rashes, cramps in the calf muscles. With long - term use Raynaud's syndrome; privlechenii high doses (parkinsonism) - confusion, fainting, peptic ulcer, gastrointestinal bleeding, black stools, blood in vomitus), retroperitoneal fibrosis (abdominal pain, decreased appetite, back pain, nausea, vomiting, weakness, frequent urination). It should also be noted that for the prevention of nausea and vomiting in the early treatment of patients it is advisable to prescribe antiemetic drugs for 1 h before administration of the drug. It is recommended that continuous monitoring of blood pressure, liver and kidney. Patients receiving the drug bromkriptin, you should refrain from engaging in activities that require attention and rapid physical and mental reactions. The treatment can cause accelerated resumption of ovarian function after birth, and therefore should be warning women about the possibility of early postpartum conception. All of the above side effects reduce the quality of life of patients with acne. Also the author additionally in the treatment of patients used intramuscular injection of vitamin E, the disadvantage of this route of administration of the drug is that at the injection site occur edema, erythema, calcification of soft tissues.
The technical task of the invention is the reduction of treatment time by invites the clinical picture of patients with acne, which leads to reduced and full resolution structural elements of acne on the skin, improving the quality of life of patients during and after treatment.
The problem is solved by assigning linseed oil 10 ml 2 times a day, sodium Selenite 90 mcg 1 time per day, tocopherol acetate 100 mg 2 times daily for 1 month.
The invention consists in creating a treatment for acne, it is pathogenetically substantiated method, which should be the normalization of lipid imbalance in the cells of the sebaceous glands due to exogenous arrivals of polyunsaturated essential fatty acids, which leads to improving the quality of life of patients with acne.
The pathogenesis of acne is complex, according to modern concepts in the development of acne) essential acceleration of lipid peroxidation, which is one of the most important mechanisms regulating the state of the membranes and cells.
One of the pathogenetic factors of acne is a deficiency of linoleic acid in follicular epithelium, contributing to the disruption of the processes of keratinization in the mouth of the hair follicles, follicular damage of the epithelial barrier, the dysregulation of IL-8 secretion (Jappe U., 2003; Kabaeva T., Osipov G.A., 2004).
Free fatty acids are one of the most important Atila the systematic inflammatory factors (Dolitsky C. et al., 1988). It has long been known that free fatty acids give comedongenic effect (Kligman A.M. et al., 1970).
Itself linoleic acid is an essential fatty acid exogenous origin, i.e. it enters the body with food and delivered to the sebaceous glands via the blood. Cells of the sebaceous gland, receiving acid from peripheral blood, where its concentration is relatively stable, part of it is disposed of, and another part of the produce with a secret.
The concentration of linoleic acid depends on its quantity in each individual cell of the sebaceous glands at the beginning of the differentiation and the degree of dilution of the original number of linoleic acid lipids synthesized in the following in each cell of sebaceous glands. At the time of division, when there is contact with the basal membrane of the cells have access to circulating lipids, including linoleic (Kabaeva TI and al., 2004).
For the treatment of acne using different methods and groups of drugs as a system - integrated and external use. Considered the most effective holistic treatments and their combination with the exterior.
Method the proposed method consists in the appointment of linseed oil 10 ml 2 times a day, sodium Selenite 90 mcg 1 time per day, tocopherol acetate 100 mg 2 times daily for 1 month.
Lin is a great oil - the oil contains a balanced composition of polyunsaturated fatty acids, due to the high content of unsaturated fatty acids (%) : 15-30 linoleic, 44-61 linolenic and 13-29 oleic.
Sodium Selenite is an antioxidant that operate in conjunction with tocopherol acetate.
Tocopherol acetate is a fat - soluble vitamin, was appointed as an antioxidant, which inhibits the development of free radical reactions, prevents the formation of peroxides that damage cellular and subcellular membranes, which is important for patients with acne. Together with selenium inhibits the oxidation of unsaturated fatty acid (a component of the microsomal system electron transfer), prevents hemolysis of red blood cells. Is a cofactor for some enzymatic systems.
In accordance with the objectives of the research under our observation were patients with acne (acne). Before and after treatment all patients underwent determination of antioxidant activity by the level of catalase and glutathione peroxidase and lipid peroxidation the level of malondialdehyde and diene conjugates by spectrophotometry.
While we noted a significant decrease of the level of catalase and glutathione peroxidase in serum of patients with mild and moderate forms of the tois and increased levels of malondialdehyde and diene conjugates.
Additionally, we have carried out a study of medical documentation, analysis of complaints, anamnesis data and objective examination of the patients.
The results of our research confirm the changes of free radical processes in patients with acne.
The decrease in antioxidant capacity of blood serum of patients with acne proves deleterious effects of lipid peroxidation, the voltage of the mechanisms of antioxidant protection and development of "oxidative stress".
Patient K., aged 22. He complained of a rash on the skin for 5 years. Last year used only external treatment. Patient diagnosis: Acne, papules-pustular form, moderate severity. The patient received treatment with the claimed method, resulting in 2.5 weeks of therapy there was a significant improvement in disease - no new items rash, papular elements were in stage regression, remained only a few spots on the face. When observation of the patient during the year the patient had no complaints, rashes on the skin was not.
Patient M. 19 l was treated with a diagnosis of papular form of acne, mild severity. Were treated linseed oil - 10 ml 2 times a day, sodium Selenite 90 mcg 1 time per day, tocopherol AC is tat 100 mg 2 times a day for 1 month, no side effects were. At the end of 4 weeks of treatment, the rash resolved completely.
Based on the above, taking into account the peculiarities of pathogenesis of acne, it should be noted that in the complex therapy of patients with acne it is advisable to include drugs with antioxidant properties, as a result, we have developed a new method of complex treatment of patients with acne with the use of polyunsaturated fatty acids and antioxidants.
The claimed invention allows to significantly reduce the treatment time, improve outcomes for patients with acne and enables you to achieve long-term remission.
A method of treating acne by assigning medicines, characterized in that the prescribed linseed oil 10 ml 2 times a day, sodium Selenite 90 mcg 1 time per day, tocopherol acetate 100 mg 2 times daily for 1 month.
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to cosmetology and dermatology, and represents a water-based formulation for local application for treating acne, containing water, a water-miscible organic solvent and benzoyl peroxide, wherein the organic solvent concentration is 1-4 times higher than the benzoyl peroxide concentration in the formulation; the water and organic solvent concentrations are related as at least 7:1, preferentially at least 10:1, more preferentially at least 20:1; the benzoyl peroxide concentration in the formulation makes less than 5.0 wt %, but at least 1.0 wt %.
EFFECT: invention provides the clinical effectiveness with the reduced active agent concentration, as well as reduced irritant action.
27 cl, 4 ex, 3 tbl
SUBSTANCE: invention refers to cosmetology and represents a cosmetic composition containing: hydrolised yeast proteins as an active substance, and at least one acceptable carrier, differing by the fact that the above hydrolised yeast proteins are prepared by exogenic enzymatic hydrolysis and/or acid hydrolysis and/or alkaline hydrolysis of the yeast membranes.
EFFECT: invention provides improved cosmetic activity, excellent time stability.
17 cl, 6 ex, 3 tbl, 2 dwg
SUBSTANCE: invention refers to medicine, specifically to dermatology, and may be used for treating the patients suffering acne. That is ensured by local applications of a therapeutically effective amount of a fixed-dose combination containing adapalene and benzoyl peroxide. That is combined with oral administration of a therapeutically effective amount of an antibiotic for a particular period of time.
EFFECT: method provides the effective treatment of these patients, manifested as a significant decrease of all types of acne involvements, prevents the further development of these involvements, including after the withdrawal of oral antibiotics and the development of resistance, due to the synergistic effect of the above local combination and oral antibiotic.
11 cl, 11 tbl, 4 dwg, 2 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine and cosmetics, more specifically to a topical pharmaceutical composition possessing comedolytic and antibiotic action, comprising an effective amount of the antibiotic clindamycin, salicylic acid and excipients. The pharmaceutical composition is presented in the form of a gel. The excipients are as follows: acrylate copolymer emulsion Salcare SC80, allantoin, antioxidant dihydroquercetin preservative Sharomix MCI, propylene glycol, cyclomethicone DC 345, tocopherol phosphate, UV filter Escalol 567, emulsifier DC 5329, trometamol and thermal water.
EFFECT: stabilised composition has strong comedolytic and antibiotic action, comprises the protective SPF factor which protects inflamed skin against the negative effects of UV radiation and has a shelf life of at least 3 years.
3 ex, 4 tbl
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of pharmaceutics and represents application of composition, including adapalene and benzoyl peroxide, in preparation of local medication, intended for application by patient who requires it to provide long-term treatment of acne vulgaris, where scheme of application of local medication includes application of therapeutically efficient quantity of composition for, at least, 9 months.
EFFECT: invention ensures achievement of stable positive effect in long-term treatment of acne with composition, including adapalene and benzoyl peroxide, as well as absence of side effects.
19 cl, 1 ex, 3 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of dermatology and represents application of 1-aminoalkylcyclohexane derivative, selected from neramexane and its pharmaceutically acceptable salts for treatment or prevention of inflammatory skin diseases, which represent acne, irritant dermatitis, impetigo and atopic dermatitis.
EFFECT: invention ensures extension of arsenal of medications for treatment of inflammatory skin diseases.
39 cl, 7 ex, 35 tbl, 5 dwg
SUBSTANCE: invention relates to medicine, particularly to dermatology, more specifically to methods of treating pyoinflammatory skin diseases, particularly furunculosis and acne. The method of treating the patients suffering pustular skin disorders, according to the invention, consists in the fact that the affected and surrounding skin areas are prepared with warm weak antiseptic, dried and further processed with an ointment prepared by thorough mixing on a water bath until smooth: zinc-salicylic paste, Lorinden C, gioxizone, streptocide liniment, synthomycin liniment and retinol acetate in the ratio of 3÷1÷1÷1÷0.8÷0.1 with skin treatment produced 2 times a day. The weak antiseptic is sodium bicarbonate or chamomile infusion at temperature 40-45°C. Besides, water bath temperature is to be 40-50°C, and the ointment is to be prepared is a glass or ceramic container. Face acne requires the affected area to be warmed with a vapour bath before finally applying the ointment. To prevent accidental wipe-out of ointment from the ointment treated skin, it is covered with the napkins attached to healthy skin. To enhance the effect of the ointment applications, the affected skin is exposed to UV lamp and/or sunlight for 10-30 minutes.
EFFECT: method enables faster treatment and prevented the recurrent disease, and also ensures the prevention of side effects and provides outpatient treatment.
6 cl, 7 dwg
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to cosmetology and dermatology and represents a composition for treating dermatological disorders containing in a physiologically acceptable medium, at least: (i) peroxide benzoyl, (ii) a naphthoic acid derivative specified in 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid, 6- [3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthoic acid, 6-[3-(1-adamantyl)-4-decyloxyphenyl]-2-naphthoic acid and 6-[3-(1-adamantyl)-4-hexyloxyphenyl]-2-naphthoic acid and (iii) a compound of polyurethane polymer representing a polyol pre-polymer with said naphthoic acid derivative and said benzoyl peroxide being found in the dispersed form in said composition.
EFFECT: invention provides producing a non-irritant stable composition.
25 cl, 8 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to chemical-pharmaceutical industry, and concerns preparing an agent for treating various dermatopathies: psoriasis, eczema, atopic dermatitis, ulcers incl. trophic and other diseases accompanied by inflammation or skin flaking. According to the first version, the composition contains ethoxylated alcohol, glycerol monostearate, higher fatty alcohols C16-C18 and cocoglycerides, as well as glycerol, olive oil and water. According to the other versions, it contains naphthalan oil or pentoxifylline or urea. All the versions provide a liposomal form of the composition improving healing, soothing and trophic effects.
EFFECT: composition is hypoallergic, easy-to-use.
12 cl, 8 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to new benzimidazole derivatives of general formula (I) or to its pharmacologically acceptable salts wherein R1 represents a C6-aryl group which can be substituted by 1-3 groups optionally specified in a group of substitutes (a), or a heterocyclic group which represents pyridyl, dihydrobenzofuranyl, 1,3-benzodioxolyl, tetrahydropyranyl, tetrahydrofuranyl which can be substituted by 1-3 groups optionally specified in a group of substitutes (a), R2 represents a C1-C6 alkyl group, R3 represents a C6-aryl group which can be substituted by 1-2 groups optionally specified in a group of substitutes (a), Q represents a group represented by formula =CH-, or a nitrogen atom and a group of substitutes (a) represents a group consisting of a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a carboxyl group, a C2-C7 alkylcarbonyl group, a C2-C7 alkoxycarbonyl group, a C1-C6 alkoxy group, a C1-C6 halogenated alkoxy group, an amino group, a 4-morpholinyl group and a di-C1-C6 alkyl)amino group. Also, the invention refers to a pharmaceutical composition based on a compound of formula (I), to a PPARγ activator/modulator based on the compound of formula (I), to using the compound of formula (I), to a method of reducing blood glucose, to a method of activating PPARγ, a method of treating and/or preventing said pathological conditions.
EFFECT: there are produced new benzimidazole derivatives showing PPARγ modulatory activity.
41 cl, 2 dwg, 6 tbl, 76 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to preparing a drug possessing antiulcerogenic, antistress and hemostatic activities. The declared method involves mixing the dry extracts of great nettle leaves, knotgrass herb and nosebleed herbs with fine powders of ginger rhizomes and cinnamon bark in ratio, weight fraction 35: 30 : 10 : 20 : 5. The above dry extracts prepared by multiple extraction of the herbal raw materials in ethanol and water, filtration of the prepared extracts, evaporation thereof, concentration and drying in a vacuum oven, wherein the first and second extractions of the herbal material is carried out in 80% ethanol, the third and fourth extractions - in 40% ethanol, and the fifth and sixth extractions - in boiled water.
EFFECT: invention provides preparing the effective and safe drug for preventing the digestive diseases.
7 tbl, 1 ex
SUBSTANCE: invention relates to veterinary science and aims at treating and preventing sheep scab. Everlong 0.2 mg/kg of animal's body we is introduced into the animals. Evomec 1 ml/50 kg of anima's body weight is introduced subcutaneously 50-60 days after administration of Everlong.
EFFECT: method enables prolonging the therapeutic effect of Evomec and the length of preventing scab, increasing the effective control of the above disease and reducing the labour input.
2 cl, 2 ex
SUBSTANCE: invention refers to ophthalmology and may be used for treating degenerative and dystrophic retinal diseases. That is ensured by subcutaneous introduction of the preparation Coenzyme compositum 0.5 ml within the mastoid process, the preparation Lymphomyosot - within the temporal fossa, as well as by parabulbar introduction of the preparation Placenta compositum. The course is 10 sessions every second day 1-2 days a year. The introductions are double-sided if the retina in both eyes is involved.
EFFECT: invention provides improving the peripheral circulation in the eyes, increasing visual acuity due to the integrated effect of the drugs administered.
2 cl, 5 ex
FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to chemical-pharmaceutical and cosmetic industry and represents a hygienic handwash, preferentially before using contact lenses. The hygienic handwash contains ethanol, glycerol, 1,2-propylene glycol, Pherol A, Aloe Vera extract, a flavour and water; as an antibacterial additive, the product contains polyhexamethylene biguanidine hydrochloride, while a moisturising supplement - KM-25 (water/propylene glycol extract of glucomannan) in the following proportions, wt %: Rectified ethanol 56.0-65.0; Glycerol 0.6-2.0; 1,2-propylene glycol 0.7-1.2; KM-25 (water/propylene glycol extract of glucomannan) 0.009-0.012: Pherol A 0.009-0.015; Aloe Vera extract 0.008-0.02; Flvour 0.05-0.07; Polyhexamethylene biguanidine hydrochloride 0.1-0.5; Water - up to 100%.
EFFECT: invention provides developing a product for effective hand protection and cleansing.
2 cl, 1 tbl
SUBSTANCE: invention refers to a new method for preparing an antiperspirant active compound having SEC chromatogram showing high SEC peak 4 intensity. The method involves heating an aqueous solution containing an aluminium salt having a molar ratio of aluminium to chlorine of 0.3:1 to 3:1, optionally with a buffer substance at temperature 50°C to 100°C in a backflow condenser tank for 1 hour to 6 hours to prepare an aluminium salt solution, adding an aqueous solution of sodium hydroxide for preparing the aluminium salt solution having the molar ratio of OH:Al 2:1 to 2.6:1 so that to prepare the aluminium salt solution with adjusted pH, having pH 2 to 5, providing calcium ions and adding optionally an aqueous solution containing zirconium to the aluminium salt solution with adjusted pH so that to prepare the aluminium and zirconium salt solution having the molar ratio of aluminium and zirconium 5:1 to 10:1. When the calcium base is used, the weight ratio of sodium hydroxide to the calcium base falls within the range of more than 0 to 20, or when a calcium ion source represents a salt, then the weight ratio of sodium hydroxide to the calcium ions falls within the range of more than 0 to 11.
EFFECT: method enables simplifying the stage of purification of the prepared antiperspirant product.
22 cl, 5 ex
SUBSTANCE: invention refers to medicine, namely to gynaecology. The method involves the daily transcranial electrical stimulation and drug administration. The transcranial electrical stimulation is characterised by current intensity 1.0÷1.5 mA, 20 - 30 minutes for 10÷15 days. In addition, the patients intakes the phytocomposition 'Myrrasyl-1'. The phytocomposition is taken 15÷20 minutes before meals 2 tablets 2 times a day for 10÷15 days. Thereafter, the phytocomposition 'Myrrasyl-1' is administered daily for 20÷30 days, 1 tablet 2 times a day; the preparation 'Sagenit' is administered before meals 1 tablet a day.
EFFECT: method provides higher clinical effectiveness in the patients suffering the hepatobiliary system by reducing the current intensity during the transcranial electric stimulation.
2 ex, 2 cl
SUBSTANCE: invention refers to biotechnology, namely to a method for preparing aqueous dispersions of nanoparticles of a natural bark triterpenoid mixture. The method comprises dissolving the triterpenoid mixture in an organic solvent, bringing the triterpenoid solution into contact with water or an aqueous solvent solution, stirring the prepared mixture, processing with hexane for one-stage removal of excessive non-polar components and the solvent, separating a hexane phase from the dispersion of nanoparticles, removing the solvent and a major portion of water to form the aqueous dispersion of nanoparticles. Removing the non-polar components, such as betulin and lupeol, provides increasing a portion of the polar component betulin caffeate in the nanoparticles of the dispersion that leads to better dispersion prepared: improving monodispersity and morphological uniformity of the spherical amorphous nanoparticles.
EFFECT: invention enables reducing the number of the production stages in the industrial production of the nanodispersions of the natural triterpenoid mixture and using the prepared nanoparticle dispersion without betulin caffeate pre-enrichment.
4 dwg, 2 tbl, 3 ex
SUBSTANCE: invention refers to medicine, and aims at treating prosthetic inflammatory diseases of the oral mucosa. The affected mucosa is coated with a therapeutic agent of the following composition, wt %: sage oil - 0.1-0.2, calendula oil - 0.1-0.2, fir oil - 0.1-0.3, mint oil - 0.1-0.3, glycerol - 14.0-20.0, sodium alginate - 5.0-6.0, pectin - 4.0-6.0, polyvinyl pyrrolidone - 2.0-3.0, lidocaine hydrochloride - 1.7-2.5, silver ions - 0.001-0.004, dimexide - 0.5-1.0, red food grade dye - 0.01-0.02, purified water - up to 100. A 0.6-1.0-mm layer of the therapeutic agent is applied 2-3 times a day for 4-10 days.
EFFECT: using the declared method provides a high therapeutic effect with no discomfort to the patient.
SUBSTANCE: invention refers to veterinary science. The method for preventing respiratory diseases in calves involves the immunisation by subcutaneous injections of donor animals' hyperimmune blood serum containing antihemagglutinin in titres to herpes virus -3 1:1280, to rednose virus - min. 1:256, to viral diarrhoea -1:1024 and to adenovirus -1:128; besides, 20-30 minutes before feeding, a pytopreparation of an alcohol tincture prepared of purple echinacea (Echinacea purpurea L) herb and blossom, common pine (Pinus sylvestris) buttons, horseheal (Inula helenium) roots and rhizomes, common liquorice (Glycyrrhiza glabra L.) roots and harmala shrub (Peganum harmala) herb taken in relation 1:1:1:1:0.5 in the amount of 7-8% of aqueous solution is administered in a dose of 2.0-2.5 ml/kg of body weight for 15 days every 24 hours.
EFFECT: invention provides the optimum preventive effect which is expressed in reducing the number of infected calves and milder course.
1 cl, 3 tbl, 2 ex
SUBSTANCE: invention refers to medicine, particularly ophthalmology, and may be used for treating corneal ulcer. That is ensured by the integrated treatment including the intake of Lymphomyosot 10 drops in 50-100 ml of water three times a day for three weeks; Traumel 1 tablet 3 times daily for three weeks sublingually; 10 subcutaneous 2.2 ml injections twice a week: Mucosa Compositum, Solidago Compositum, Coenzyme Compositum; 10 subcutaneous 2.2 ml injections of Traumeel every second day; eye instillations of Oculoheel, okulohelya, Mydriacyl and colloidal silver 2 drops 3 times a day for 10 days; sea buckthorn oil under the eyelid 3 times a day for 10 days; Solcoseryl ointment or gel in the conjunctival cavity until observing the complete epithelialisation, and also the radiotherapy course from the first day of treatment in a dose of 50 cGy daily, within 5 sessions. The severe corneal opacities require the additional 5 sessions of the repeated radiotherapy course in a dose of 500 cGy daily following the 5-session radiotherapy course in a dose of 50 cGy three months later.
EFFECT: method enables increasing or recovering the visual acuity ensured by ulcer epithelisation with no side effects.
SUBSTANCE: claimed invention relates to application of effective quantity of selenate or its pharmaceutically acceptable salt in methods and compositions for treatment or prevention of neurological disorders, which are are not related to tauopathy. Neurological disorder, which is not related to tauopathy, is not a-synucleinopathy. Effective quantity of selenate or its pharmaceutically acceptable salt delivers over-dietary quantity of selenium. In some implementations invention relates to application of selenate or its pharmaceutically acceptable salt in combination with other means of therapy for application in methods of treatment or prevention of neurological disorders, which are not related to tauopathy.
EFFECT: treatment or prevention of neurological disorders, which are not related to tauopathy.
2 ex, 9 dwg