Dental seal

FIELD: medicine.

SUBSTANCE: group of inventions relates to dental seals and methods of their application. Composition of dental seal in form of varnish includes arginine in free form or in form of salt, rosin, white beeswax, mastic, shellac and source of fluoride ions, which is present in composition in concentration, at least 12 wt %, and is selected from group, including tin fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, aluminium fluoride, sodium hydrofluoride, sodium fluoride, calcium fluoride, magnesium fluoride and potassium fluoride. Also claimed is method of treating sensitive teeth, which includes application of said seal composition in form of varnish on tooth of person, requiring treatment, and application of claimed method for improvement of oral cavity health. Application of arginine in said composition of dental seal makes it possible to use fluoride-ions in a larger quantity than is usually used in dental varnishes, without side effects, associated with excess of fluoride-ions.

EFFECT: composition of seal makes it possible to ensure regulated continuous supply of medication.

12 cl, 2 ex

 

The technical field

The present invention relates to a dental hermetics, including basic amino acid in free form or in salt form, which can be used to prevent the demineralization of teeth, relieve pain and/or sensitivity of the patient's teeth, and to provide other advantages. Sealants may include polymer coatings, varnishes and foam to cover the teeth and/or dental appliances for extended periods.

Prior art

Dental caries is demineralization of the tooth caused by bacteria. In the early stages of decay on the tooth develops a white spot and, if the disease is not stopped and is not treated, the surface of the enamel is destroyed, creating damage. This can then lead to rot, and ultimately, to the crumbling of the tooth. It is known that the development of dental caries can be reduced by various factors, such as diet and oral hygiene, antimicrobial treatment and providing the tooth with fluoride.

Tooth sensitivity is a common problem, affecting children and adults. In General, tooth sensitivity can be caused by gum recession, exposed dentin due to erosion or abrasion, or periodontal surgery, which involves aligning the surface of the roots. Such conditions leave dentinal canal the C fabrics prone to irritation chemical, bacterial, mechanical, or thermal stimuli. Examples of stimuli include heat, cold and sweet foods. It is believed that the sensitivity comes from the nerve endings in the pulp, excited by the flow of fluid through the open dentinal tubules.

Treatment is aimed at relief of pain associated with sensitive teeth, usually focuses on how to block access to the dentinal tubules to prevent incentives caused pain and sensitivity. We developed many methods of treatment that include the use of inorganic or organic components, designed to occlude or otherwise block the dentinal tubules for a limited period. The disadvantage of this treatment is that normal habits such as the consumption of certain products (for example, foods with a high acid content) or brushing can undermine treatment. Recently, testing has shown that elevated levels of fluoride in the oral cavity can also be used for treatment of tooth sensitivity (Toumba and Andreadis).

Current methods of introduction of fluoride for caries prevention include fluoridation of drinking water, the intake of fluoride containing tablets, the inclusion of fluoride in the liquid for mouth rinses, toothpastes and products, IU is the based use of fluoride containing solutions, gels and varnishes, and recently, the inclusion of fluoride containing compounds in dental materials and devices.

Evidence supports the concept of frequent applications of relatively low concentrations of fluoride ions for caries prevention and treatment of sensitive teeth. The system is slow and regulated selection could help to achieve this goal.

Arginine and other basic amino acids have been proposed for the maintenance of the oral cavity and is considered to have a significant advantage in the struggle with the formation of the cavity damage and sensitivity. The combination of these basic amino acids with minerals useful in the care of oral cavity, for example, a compound of fluorine and calcium, with a product for the care of the oral cavity, with acceptable long-term stability, however, proved to be a difficult problem. Partly due to unaddressed difficulties with the composition and partly because arginine is generally considered the technology as a potential alternative to the connection of fluorine, and not as means acting together, there was a weak motivation to do products for the care of the oral cavity, including arginine, and the connection of fluoride. Additional problems potentially arise due to the addition of bactericidal additives. Commercially available ar the Yining-containing toothpaste, such as ProClude® and DenClude®, for example, contains arginine bicarbonate and calcium carbonate, but does not contains neither fluoride nor any bactericidal additive.

The invention

In one embodiment, the invention provides a dental sealant, comprising a basic amino acid in free form or in salt form (UAC). The sealant composition can additionally include a fluoride containing compound. Preferred UAC is arginine, in free form or in the form of an orally acceptable salt.

In another embodiment, the present invention relates to a method of treating sensitive teeth basic amino acid in free form or in salt form (KLA) in the sealant composition, preferably in the presence of fluoride containing compounds. The method includes: (1) the application of the sealant composition, highlighting the KLA, on the teeth of the person; and (2) enable UAC slowly released over a long period of time to reduce chronic and/or acute tooth sensitivity. Preferably, the sealant also acts as part of allocating fluoride containing compound. Because the method depends on the selection of the KLA in the oral cavity, the method also prevents future pain associated with dental caries, preventing demineralization and maintaining the strength of enamel.

The invention further provides methods of improving the status is I the health of the mouth, including the use of dental sealants, including UAC, for example, subjects in need to a) reduce or inhibit formation of dental caries, (b) reduce, repair or inhibit early enamel lesions, (c) reduce or inhibit demineralization and cause remineralization of the teeth, (d) reduce hypersensitivity of the teeth, (e) reduce or inhibit gingivitis, (f) to cause wounds or cuts in the mouth, (g) to reduce the levels of bacteria that produce acid, (h) to increase relative levels alginolyticus bacteria, i) suppress the formation of microbial biofilms in the oral cavity, j) to raise and/or maintain plaque pH at levels of at least 5,5, following the release of the sugar, k) to reduce the buildup of plaque, l) to treat dry mouth, m) whiten teeth, n) enhance systemic health, including cardiovascular health, e.g., by reducing potential for systemic infection via the oral tissues, o) to reduce erosion of the teeth, p) immunize the teeth against cariogenic bacteria, and/or q) to clean the teeth and oral cavity.

The invention further provides the use of oak in the production of a dental sealant, for example, for use in the treatment of sensitive teeth, or in any of the ways set forth above.

The sealant compositions may be used to relieve pain and/or sensitivity of the teeth to the stage is the implementation to any effect, the sealant compositions that produce the KLA may have in the prevention of dental caries. The compositions can be applied to the tooth to provide a device slowly emit the KLA, to highlight the KLA in the saliva of the person.

The daily rate of dissolution (ENR) of the composition in the mouth can vary from approximately 0.1 to approximately 100% per day. Necessary ENR sealant composition will depend on the desired duration of the allocation of the KLA. For example, if the composition is required to select UAC for a long period, such as 1-2 years, ENR is preferably from approximately 0.1 to approximately 0.5%. However, if the UAC should be allocated only for a shorter period, such as several hours, days, weeks, or months, can be used more quickly released sealant, for example, with ENR to approximately 100%.

"The composition of dental sealant" means a composition that is applied to the teeth. The compositions can be applied as a spray, for example, by using a hydrocarbon gas propellant. Alternatively, the compositions include a polymer or lacquer, suitable for application to teeth, alternatively, the compositions can be included in a dental cement or fillers. For example, the compositions can be applied to the tooth, for example, deposited on a molar tooth using standard dental cement or as a powder DL is adding to dental materials such as dental amalgam, thereby providing the means for selecting the KLA in the saliva to help in the prevention or reduction of dental caries. The powder can be incorporated into many other dental materials such as resin sealant for cracks or composite bonding material to cement the connections and brackets in orthodontic appliances. The powder can use sealants that have a lower ENR than those that are applied directly on the tooth, for example, having ENR from approximately 0.1 to approximately 1%.

These and other benefits, advantages and features of the present invention will become more apparent from the following description and appended claims, or may be learned by practice of the invention, as set forth herein.

A detailed description of the preferred options

The method of the invention includes applying a sealant composition, highlighting the KLA on human teeth, or dental device, such as a denture, and then enable UAC slowly released over a long period of time to reduce chronic and/or acute tooth sensitivity. According to a preferred variant implementation, the sealant composition, highlighting the UAC includes from about 5 to about 75 wt.% UAC and from about 5 to about 30 wt.% fluorine.

Eliminate the STV slow allocation UAC consistently raise the levels of UAC in the mouth in saliva during the period up to 2 years or more and now, it seems, completely ease the symptoms of dentin sensitivity within two weeks, with the support effect for up to six months or more in adults. Subjects reported complete elimination of the sensitivity of dentin. Was not reported and was not observed any adverse events. There is a slight tendency to an increase in plaque and gingival indices, but it is not significant.

Basic amino acids that can be used in the compositions and methods of the invention include not only natural basic amino acids such as arginine, lysine and histidine, but also any basic amino acid having a carboxyl group and the amino group in the molecule, which are water soluble, and provide a pH of the aqueous solution is 7 or more.

Accordingly, the basic amino acids include, but are not limited to, arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutane acid, diaminopropionic acid, their salts or their combination. In a particular embodiment, the basic amino acid selected from arginine, citrulline and ornithine.

In certain embodiments of the implementation of the embodiments of the basic amino acid is arginine, for example, L-arginine or its salt, for example, arginine bicarbonate, arginine phosphate, or arginine hydrochloride.

The compositions from which briteney intended for consumption and thus, salts for use in the present invention should be safe for such use in the secured amounts and concentrations. Suitable salts include salts known in the technology as pharmaceutically acceptable salts, which are considered to be physiologically acceptable to the secured amounts and concentrations. Physiologically acceptable salts include salts derived from pharmaceutically acceptable mineral or organic acids or bases, for example, additionai acid salts which are formed with acids which form a physiological acceptable anion, for example, salts of hydrochloride or bromide, and additionai salts of bases, which form a physiologically acceptable cation, for example, salts derived from alkali metals such as sodium and potassium, or alkaline earth metals such as calcium and magnesium. Physiologically acceptable salts may be obtained using standard methods known in the technology, for example, by the reaction of a sufficiently basic compound such as an amine with a suitable acid, providing a physiologically acceptable anion.

The concentration of the KLA will vary depending on the composition. In one embodiment, the KLA (the amount of salt, expressed as the weight of free base) is 1-40% by weight of the composition, in the example, 5-20%, for example, approximately 10%.

The compositions according to the invention may additionally include fluoride. Representative sources of fluoride ion include, but are not limited to, tin(2) differed, sodium fluoride, potassium fluoride, sodium monitoroff, sodium forcelimit, ammonium forcelimit, amine fluoride, ammonium fluoride, and combinations thereof. In certain embodiments of the implementation of a source of fluoride ion comprises tin(2) differed, sodium fluoride, sodium monitoroff, and mixtures thereof. In a specific embodiment, the fluoride source is sodium fluoride or sodium monitoroff. Fluoride may be present in the composition in an effective amount, such as is used in conventional dental sealants, for example, higher than commonly used in toothpaste. Fluoride may be present, for example, in amounts of from about 0.25 to about 25%, expressed as the level of fluoride ion, or in the amount of 2-25%, for example at least 12%, for example, 15-25% by weight of the composition.

The compositions may additionally include bactericidal additive, such as triclosan, or an agent that inhibits the fixing bacteria.

As used here, the intervals used as shorthand for describing each and every value that is within the interval. Any value within the interval can be is abrano as the end of the interval. In addition, all references cited here, thus, are incorporated by reference in their entirety. In the event of a conflict in the formulation of the present invention and the cited references, the present invention is dominant. Assume that, when they describe the compositions, they can be described from the point of view of their ingredients, as is common in the technology, despite the fact that these ingredients can react with each other in the actual composition, as it is made, stored and used, and such products are intended for inclusion in the described compositions.

The following examples further describe and demonstrate illustrative options within the present invention. The examples are given solely for illustration and should not be considered as limitations of this invention, as many changes are possible, without departing from the essence and scope of the invention. Various modifications of the invention, in addition to the shown and described here should be obvious to a person skilled in the art and it is assumed that they are within the scope of the attached claims.

Examples

Example 1

Compositions comprising 10 wt.% arginine bicarbonate, prepared as follows:

Table 1
Part 1
Ingredient%
Wateras needed
Sodium fluoride2,65
Malic acid1,75
Sodium monophosphate1,38
Nutrientlimited1
Flavor0,6
Nachrichten0,35
Sodium benzoate0,1
Arginine bicarbonate10
Total (part 1)100

Part 2

Part 193
Hydrocarbon gas mixture-eject7
The total number of100

Example 2

The lacquer composition comprising 10 wt.% the arginine hydrochloride, obtained as follows:

Table 2
Ingredient%
Rosin22,01
90% Ethyl alcohol27,87
Shellaca 21.5
Mastic11,82
Sodium fluorideto 4.98
Nachrichten0,68
Raspberry flavoring0,65
White beeswax0,48
Arginine hydrochloride10
Total100

1. A method of treating sensitive teeth, including:
the application of the sealant composition in the form of a varnish comprising arginine in
free form or in salt form,
at least about 12 wt.% source of fluoride ions; and
rosin, white beeswax, mastic, shellac;
on human teeth in need of treatment.

2. The method according to claim 1, in which the source ft the reed-ion is excreted slowly in a long time.

3. The method according to claim 2, in which the source of fluoride ions selected from the group consisting of tin fluoride, sodium monophosphate, sodium fertilitate, ammonium fertilitate, amine fluoride, aluminum fluoride, sodium hydrohloride, sodium fluoride, calcium fluoride, magnesium fluoride and potassium fluoride.

4. The method according to claim 3, in which the source of fluoride ions present in the composition in a concentration of from about 15 to about 25 wt.%.

5. The method according to claim 4, in which the composition has a daily rate of dissolution in the range from approximately 0.1 to approximately 0.5%.

6. The method according to claim 1, wherein the sealant composition further includes a source of potassium ions.

7. The method according to claim 6, in which the source of potassium ions is selected from potassium nitrate and potassium chloride.

8. Composition of dental sealant in the form of a varnish comprising arginine in free form or in salt form, rosin, white beeswax, mastic, shellac, and a source of fluoride ion,
and the composition has a daily rate of dissolution in the range from approximately 0.1 to approximately 100%,
the source of fluoride ions present in the composition at a concentration of at least about 12 wt.%, and selected from the group including tin fluoride, sodium monitoroff, sodium forcelimit, ammonium forcelimit, amine fluoride, aluminum fluoride, sodium hydroptere, sodium fluoride, calcium fluoride, magnesium f is arid and potassium fluoride.

9. The sealant composition of claim 8 in which the composition has a daily rate of dissolution in the range from approximately 0.1 to approximately 0.5%.

10. The sealant composition of claim 8 in which the sealant composition further includes a source of potassium ions.

11. The sealant composition of claim 10 in which the source of potassium ions selected from potassium nitrate and potassium chloride.

12. Application of the method according to any one of claims 1 to 7 for the improvement of oral health.



 

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