Method of predicting version of minimal brain dysfunction (mbd) course

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to neurology, psychiatry and pediatrics. Factors of perinatal pathology risk are determined: extragenital diseases of mother during pregnancy and labour, complications of pregnancy and labour, low gestational age, estimation by Apgar scale and compromised obstetric history. Also determined is presence of neurological malfunctions during 1-st year of life: syndromes of motor malfunctions, increased neuroreflex excitability, vegetative-visceral disorders, depression, retardation of physhomotor and speech development; and in older age - cerebrosthenic syndrome and syndrome of child dysphasia in structure of symptom complex of MBD, epileptiform activity by EEG. Results of questionnaire for MBD detection are evaluated in points. Prognostic coefficients F1 and F2 are calculated in discriminating equations. If F1 is higher than F2, favorable course of MBD is predicted, if F1 is less than F2, unfavorable course of MBD is predicted.

EFFECT: method makes it possible to increase reliability of MBD course prediction.

2 tbl, 2 ex

 

The present invention relates to the field of medicine, namely, neurology, psychiatry and Pediatrics and can be used to predict the development of the current version of minimal brain dysfunction (MBD).

As is well known, minimal brain dysfunction refers to the perinatal encephalopathy. Perinatal encephalopathy is a collective diagnosis, implying a violation of the functions or structure of the brain of different origin, arising in the perinatal period. MMD - light behavior disorder and learning without obvious intellectual disorders that arise due to the failure of the functions of the Central nervous system (CNS), often residual organic nature (Modern approaches to diagnosis and treatment of minimal brain dysfunction in children: guidelines / N.N. Zavadenko (other) // M. Ed. That is, Razumova, 2003, p.7.).

There is a method of predicting the course and outcome in full-term neonates with structural and functional lesions of the CNS hypoxic-ischemic gecesi. The method involves performing neurosonography and electroencephalography (EEG). When computer analysis of EEG identify indicators spectral power 5-rhythm and its spatial distribution. If from the first day of the intensive care unit Max. spectral indices powerfully the minute mark in the occipital and parietal areas, and for 2-3 days Moscone features 5-rhythm reliably prevail in the left hemisphere compared to the right, predicts favorable outcome of the disease (Method of predicting the course and outcome of hypoxic-ischemic lesions of the Central nervous system in neonates with respiratory distress syndrome: Proposal No. 99116686/14 EN: IPC7A61B 5/0476 Masalitinova IV, Zorin CENTURIES, Musicians A.A. 2001.06.10).

The disadvantages of this method include the fact that the forecast carried out in full-term newborns with the presence of respiratory distress syndrome, which is more common in moderate and severe hypoxic-ischemic encephalopathy, while the MMD may be the outcome of lighter disorders of the Central nervous system, which in the neonatal period have no clinical manifestations.

Closest to the present invention is a method for predicting neurological diagnosis to 2 years in children who have had a critical condition in the early neonatal period, including the identification of prognostic criteria and calculation of the index of refraction (a predictor of neurological diagnosis 2 years in children who have had a critical condition in the early neonatal period: Proposal No. 2007106615/14 EN: IPC7A61B 10/00 A61B 5/00 G01N 33/48 I. Zaitseva. 2007.02.21).

As a prognostic criteria of Central nervous system IP is result indicators: duration of artificial lung ventilation (ALV), saturation of the blood, blood glucose level, total number of organ dysfunctions and prenatal risk factors. To prenatal risk factors include: extragenital diseases of the mother during pregnancy and childbirth, complications of pregnancy and childbirth, low gestational age.

The method allows to predict clinical outcomes in newborns undergoing resuscitation and mechanical ventilation in the neonatal period and, therefore, is an objective measure for the purpose pathogenetically justified therapy

The disadvantages of this method of forecasting should include its lack of precision, because not take into account all factors of perinatal risk and does not clarify the nosology manifestations of lesions of the nervous system.

The task of the invention is to develop a method for predicting the current version of MMD.

The technical result of the proposed method is to provide opportunities to assess the risk of adverse the current version of MMD, and also to simplify the method, by eliminating invasive methods.

The technical result of the proposed method is achieved by predicting the current version of minimal brain dysfunction (MBD) includes identifying the risk factors of perinatal pathology: extragenital diseases of the mother during remeberence and childbirth, complications of pregnancy and childbirth, low gestational age.

The difference lies in the fact that additionally reveal the presence of neurological disorders on the 1st year of life: syndromes musculoskeletal disorders, increased nervno-reflex excitability, autonomic and visceral disorders, depression, psychomotor and speech development.

The difference also lies in the fact that reveal zerebrasteniceski syndrome and syndrome of childhood distasi in the structure of the symptom complex of the MMD, epileptiform activity on EEG data, scored detection MMD according to the questionnaire.

Establish grades and numeric values of each risk factor. Then prognostic factors F1and F2determined by the formula:

F1=-2,39 to 0.75*X3-1,25*X2-0,8*X16-0,65*X4-0,30*X15-0,73*X14-0,339*X10+0,73*X13-1,22*X7-1,24*X8-0,94*X9-0,36-X110.39 per*X5+0,63*X1-0,30*X6+0,37*X12

F2=-2,43+0,77*X3+1,27*X2+0,82*X16-0,67*X4+0,31*X15+00,71*X14+0,34*X10-0,75*X13+1,22*X7+1,26*X8+0,95*X9+0,37*X11+0,41*X5-0,63*X1+0,30*X6-0,36*X12

accordingly, where the digital values represent constants discriminant equations and correlation coefficients.

X1, 2...16/sub> - grades and numerical values of risk factors:

X1- estimation on Apgar scale: above 7 points - 0; 7 points and below - 1;

X2- gestational age: Mature - 0 premature - 1, a late - 2;

X3- burdened obstetric history (presence of 3 or more previous abortions): none - 0, 1;

X4- chronic inflammatory disease of the reproductive system of the mother during pregnancy and childbirth: no - 0, 1;

X5- features childbirth: physiological - 0, pathological - 1, caesarean section - 2;

X6chronic intrauterine hypoxia: no - 0, 1;

X7syndrome musculoskeletal disorders: no - 0, 1;

X8- nervno-reflex excitability: no - 0, 1;

X9- autonomic-visceral disorders: no - 0, 1;

X10- depression syndrome in the early neonatal period: none - 0, 1;

X11- delay of psychomotor and speech development: no - 0, 1;

X12- zerebrasteniceski syndrome: no - 0, 1;

X13syndrome children distasi: no - 0, 1;

X14the combination of syndromes: one syndrome is 0, the two syndrome - 1, three syndrome - 2;

X15- the presence of spirational activity by EEG: no - 0, 1;

X16- the number of points on the detection of MMD on the questionnaire.

Forecast OS which effect the function with the largest value.

If F1more F2the child falls into the group of favorable currents MMD.

When F1less F2the child is adjudged to be at risk for development of adverse currents MMD.

The authors of the proposed method is set constant values:

F1=-2,39;

F2=-2,43

The risk of adverse currents MMD evaluated using the predictive index (PI), which is calculated by the formula:

PAnd=11+e(F1-F2)

where, e is the base of natural logarithm.

From the above formula it follows that the 0.5<PI<1. If PI in the range of 0.5-0,64, the degree of risk scenarios MMD low, with PI in the range of 0.65-0.84 - average, in the range of 0.85 to 1.0.

The following table 1 shows the characteristics of the signs and the coefficients of the discriminant functions (K1, K2j):

Table 1
SignsGradingTo1jK2j
the valuation on Apgar scale (X 1)0 - Wyse points;0,63-0,63
1-7 points and below
Gestational age (X2)0 - informed;-1,251,27
1 is premature;
2 - advanced
Burdened obstetric history (X3)0 - no, 1 - -0,750,77
Chronic inflammatory diseases of the reproductive system of the mother during pregnancy and childbirth (X4)0 - no,-0,650,67
1 -
Features childbirth (X5)0 - physiological,0.39 per0,41
1 - pathological,
2 - cesarean section
Chronic intrauterine, HYPOXI the fetus (X 6)0 - no,-0,300,30
1 -

Somatoneurological features of the 1st year of life:-1,221,22
syndrome musculoskeletal disorders (X7)0 - no,
1 -
syndrome increased nervno-reflex excitability (X8)0 - no,-1,241,26
1 -
syndrome of vegetative-visceral abnormalities (X9)0 - no,-0,940,95
1 -
- depression syndrome (X10)0 - no,-0,3390,34
1 -
- ass who Rica psychomotor and speech development (X 11)0 - no,0.31 supranational0,37
1 -
Neurological syndromes after 1 year:0,37-0,36
syndrome zerebrasteniceski (X12)0 - no,
1 -
syndrome child dysphasia (X13)0 - no,0,73-0,75
1 -
the combination of neurological syndromes (X14)0 - no;-0,730,71
1-2 syndrome;
2-3 syndrome
The presence of epileptiform activity on EEG data (X15)0 - no,-0,300,31
1 -
The result of the questionnaire on yavleniem, points (X16)from 0 to 49-0,80,82

When the detection of minimal brain dysfunction use the following questionnaire (table 2).

When selecting the most appropriate response using the following grades: 0 - never, 1 - sometimes. 2 - often, 3 - almost constantly.

td align="left">
Table 2
1.Easily distracted by extraneous
2.Can't play quiet games
3.Prone to tantrums and anger
4.Ignores comments in his address
5.Careless and untidy in dress
6.The tendency to drop out of his hands"
7.Answers questions, not thinking, not waiting to hear the question
8.Talkative
9.Has difficulty tying Shoe laces, fastening buttons
10.Don't bring up the case to the end, quickly goes from pending to new
11.Can be aggressive in the game, able to hit or bite

The inability to transfer pending
another child
12.Emotional instability when failures
13.Not waiting for his turn in collective games
14.Does not like to wash, hand wash
15.In normal hearing there are moments when the child "hears"
16.
17.Does not like to participate in sports and games
18.Episodes of a bad mood (becomes unmanageable, throws, breaks things)
19.Interferes with play with other children, distracts adults
20.Conflicts with peers because of the inability to lose
21.Sloppy food
22.Uncontrolled behavior and disobedience
23.Because negligence is not able to perform the job to the end
24.Demonstrates verbal or physical aggression towards peers and / or adults
25.Has difficulty in manipuler is the training pen or scissors
26.Wants to communicate, but the contacts are accompanied by conflicts
27.Allows cries during class team
28.Does not like brushing your teeth or bathing
29.The constant movement and bustle interfere with seat and bring to the session
30.Trying to attract the attention of others by autoaggressive (falls, fights his head, biting themselves, etc.)
31.Prefer communicating with younger children
32.In connection with motor awkwardness, clumsiness breaks toys, beats utensils, etc.
33.Often loses the necessary items
34.Impulsiv the second, the overwhelming desire to pick up any object, despite the prohibitions adults
35.Does not cut their hair and / or nails
36.Spinning, spinning, fidgety, unable to sit still; arbitrarily makes excessive, purposeless movements
37.There are irrational bouts of anger, rage, anger in others
38.Child labour keeps attention when completing assignments or during games

39.Daytime incontinence of urine and / or stool
40.Departs from communication due to a lack of friendly relations
41.When walking stumbles, staggers, touches the objects that surround
42. Wanting to be the center of attention, can make a rash act, or to take excessive liabilities
43.The child is disturbed, restless, there are periods of "explosive" behavior
44.Has difficulty performing complex movements of the tongue, lips (to whistle, blow out the candle)
45.Nocturnal incontinence of urine and / or stool
46.Not able to hold the attention to detail, due to the negligence makes mistakes in their fields of activity
47.Vindictive, vengeful, cannot forgive
48.Noisy behaviour to attract attention to themselves adults and children
49.Does things that are dangerous to themselves and others actions, constantly gets into a critical situation

<> The analysis of patent and literature the authors found that the proposed method has features that distinguish it from other technical solutions in medicine and related fields of medicine and, consequently, the estimated technical solution meets the criteria of the invention of "novelty."

In the available literature we found no way of predicting the current version of MMD, taking into account the proposed set of risk factors.

A set of techniques proposed method provides the possibility of predicting favorable or unfavorable the current version of MMD. Distinctive techniques of the proposed method allows to predict the development of MMD with an accuracy of 98.2%.

Therefore, the claimed method meets the criterion of "inventive step".

A method for predicting the current version of MMD, constituting the invention, intended for use in health care. The implementation of its capabilities is confirmed as described in the application techniques and equipment. From the above it follows that the claimed invention meets the condition of patentability "industrial applicability".

The proposed method for predicting the current version of MMD is illustrated by examples of specific performance.

Example 1. Child K.L., 6 years. Observed with what iagnosis MMD. Hyperactivity and attention deficit. Expressive type of child dysphasia.

Studied perinatal history, especially the 1st year of life, the results of the clinical examination of the child, EEG, tallied the scores on questionnaire MMD, risk factors, defined their grades and numeric values:

1. A low score on the Apgar scale: 8-9, X1- 0;

2. Gestational age: Mature, X2- 0;

3. Burdened obstetric history: 3 abortion, X3- 1:

4. Inflammatory diseases of the reproductive mother: chlamydia, mycoplasmosis, ureaplasmosis, X4- 1;

5. Features childbirth: physiological, X5- 0;

6. Chronic intrauterine hypoxia: is, X6- 1;

Somatoneurological features of the 1st year of life:

7. Musculoskeletal disorders up to a year no, X7- 0;

8. Syndrome increased nervno-reflex excitability: X8- 1;

9. Vegetative-visceral disorders no, X9- 0;

10. Syndrome oppression in the early neonatal period is not observed, X10- 0;

11. Psychomotor and speech development corresponds to the age, X11- 0;

Neurological syndromes:

12. Zerebrasteniceski: otsutstvuet12- 0;

13. The presence of the syndrome child dysphasia, X13- 1;

14. The combination of syndromes: no - one neurological is Indra, X14- 0;

15. Epileptiform activity on EEG data no, X15- 0;

16. The total scores for the questionnaire to identify MMD=41, X16- 41.

Then calculate the prognostic factors F1and F2by the formulas:

F1=-2,39-0,75*1-1,25*0-0,8*41-0,65*1-0,30*0-0,73*0-0,33*0+0,73*1-1,22*0-1,24*1-0,94*0-0,36*0-0,39*0+0,63*0-0,30*1+0,37*0=37,4;

F2=-2,43+0,77*1+1,27*0+0,82*41+0,67*1+0,31*0+0,71*0+0,34*0-0,75*1+1,22*0+1,26*1+0,95*0+0,37*0+0,41*0-0,63*0+0,30*1-0,36*0=33,44

F1more F2.

Conclusion: the child falls into the group of favorable currents MMD.

Note. The forecast was carried out according to the child for 2007. In 2010, the child has no diseases of the nervous system, enrolled in grade 3, with the program successful.

Example 2. The child L.M., 5 years. Observed with a diagnosis of MMD. Hyperactivity and attention deficit. Expressive tin baby dysphasia.

Studied perinatal history, especially the 1st year of life, the results of the clinical examination of the child, EEG, tallied the scores on questionnaire MMD. Identified risk factors identified their grades and numeric values:

1. Estimation on Apgar scale: 6-7 points, X1- 1;

2. Gestational age: Mature, X2- 0;

3. Burdened obstetric history: 5 abortions, X3- 1;

4. Inflammatory diseases of the reproductive mother on the identified, X4- 0;

5. CCA the items course delivery: caesarean section, X5- 2;

6. Chronic intrauterine hypoxia: is, X6- 1;

Somatoneurological features of the 1st year of life:

7. Musculoskeletal disorders up to a year no, X7- 0;

8. The presence of the syndrome increased nervno-reflex excitability, X8-1;

9. Vegetative-visceral disorders no, X9- 0;

10. Syndrome oppression in the early neonatal period was not observed, X10- 0;

11. Delay of psychomotor and speech development: X11- 1;

Neurological syndromes:

12. Zerebrasteniceski: none, X12- 0;

13. The presence of the syndrome child dysphasia, X13- 1;

14. The combination of the two neurological syndromes, X14- 1;

15. The presence of epileptiform activity on EEG, X15- 1;

16. The total score according to the questionnaire MMD=62, X16- 62.

The calculated prognostic factors F1and F2by the formulas:

F1=-2,39-0,75*1-1,25*0-0,8*62-0,65*0-0,30*1-0,73*1-0,33*0+0,73*1-1,22*0-1,24*1-0,94*0-0,36*1-0,39*2+0,63*1-0,30*1+0,37*0=-56,35;

F2=-2,43+0,77*1+1,27*0+0,82*62+0,67*0+0,31*1+0,71*1+0,34*0-0,75*1+1,22*0+1,26*1+0,95*0+0,37*1+0,41*2-0,63*1+0,30*1-0,36*0=51,57

F2more F1

Conclusion: the child threatens the development of adverse type of flow simulation.

Note. The forecast was carried out according to the child for 2008. During the period of primary school joined the complaint on the night enuresis, crudest the school in the form of dysgraphia and dyslexia, neurotic syndrome (night terrors, fear of being alone at home, constantly gnawing the nails, ruler, pencils, pens).

Evaluation of the effectiveness of the proposed method of forecasting was conducted in the experimental group, 173 children with MMD. In the group with favorable option clinical course included 87 children with unfavorable option - 86 children. The accuracy of the prediction of adverse trends in children with MMD was 98.2%.

Thus, the proposed method allows to predict the current version of MMD. This allows children to "threatened" on the development of MMD active prevention, including the correction of the most significant "controlled" risk factors, as well as more frequent clinical and neurophysiological examinations at risk of an unfavorable course of the disease.

The proposed method of mathematical forecasting simple and does not require expensive equipment. Filling Protocol variant definition of clinical simulation can be performed not only by the doctor, but trained nurse. This method allows you to make calculations on a personal computer for 10 minutes, which contributes to the ability to quickly determine the way the clinical course of MMD and timely preventive measures.

The method can also be used on the I objective evaluation of the effectiveness of treatment of children with MMD, individualization have therapeutic and preventive measures, to predict their results, monitoring short-term and long-term efficiency and dynamic observation.

A method for predicting the current version of minimal brain dysfunction (MBD), including identification of risk factors for perinatal pathology: extragenital diseases of the mother during pregnancy and childbirth, complications of pregnancy and childbirth, low gestational age, characterized in that in addition to the risk factors of perinatal pathology include estimation on Apgar scale and burdened obstetric history, as well as identify the presence of neurological disorders on the 1st year of life: syndromes musculoskeletal disorders, increased nervno-reflex excitability, autonomic and visceral disorders, depression, psychomotor and speech development; and in the older age - zerebrasteniceski syndrome and syndrome of childhood distasi in the structure of the symptom complex of the MMD, epileptiform activity on EEG data, the scoring results of the questionnaire to identify MMD presented in table 2 descriptions, after which prognostic factors determined by the formula
F1=-2,39 to 0.75·X3-1,25·X2-0,8·X16-0,65·X4-0,30·X15-0,73·X14-0,339·X10+0,73·X13-1,22·X7-1,24·X8of-0.9·X 9-0,36·X110.39 per·X5+0,63·X1-0,30·X6+0,37·X12;
F2=2,43+0,77·X3+1,27·X2+0,82·X16+0,67·X4+0,31·X15+0,71·X14+0,34·X10-0,75·X13+1,22·X7+1,26·X8+0,95·X9+0,37·X11+0,41·X5-0,63·X1+0,30·X6-0,36·X12
accordingly,
where X1, 2...16- grades and numerical values of risk factors, and
X1- estimation on Apgar scale: above 7 points - 0, 7 points and below - 1;
X2- gestational age: Mature - 0 premature - 1, a late - 2;
X3- burdened obstetric history - the presence of 3 or more previous abortions: no - 0, 1;
X4- chronic inflammatory disease of the reproductive system of the mother during pregnancy and childbirth: no - 0, 1;
X5- features childbirth: physiological - 0, pathological - 1, caesarean section - 2;
X6chronic intrauterine hypoxia: no - 0, 1;
X7syndrome musculoskeletal disorders: no - 0, 1;
X8- nervno-reflex excitability: no - 0, 1;
X9- autonomic-visceral disorders: no - 0, 1;
X10- depression syndrome in the early neonatal period: none - 0, 1;
X11- delay of psychomotor and speech development: no - 0, 1;
X12- zerebrasteniceski syndrome: no - 0, the EU is ü - 1;
X13syndrome children distasi: no - 0, 1;
X14the combination of syndromes: one syndrome is 0, the two syndrome - 1, three syndrome - 2;
X15- the presence of epileptiform activity on EEG data: none - 0, 1;
X16the sum of the scores on the questionnaire to identify MMD
and when F1more F2the child falls into the group of course is good, MMD, when F1less F2the child gets in the risk of development of adverse currents MMD.



 

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3 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to neurology. At the first week of stroke degree of neurological deficiency is determined in patient with application of Scandinavian scale of stroke NIHSS, patient's age is taken into account, level of education is determined, content of butirylcholinesterase in blood is determined. Degree of impairment of regulatory functions (P) by 3-4 week of disease is determined by formula: P=15.13-0.095·X-0.44·Y+1.18·Z+0.36·W; where X is patient's age, Y is value of stroke scale NIHSS in points, Z is level of patient's education in points: 1 is incomplete secondary, 2 is secondary, 3 is secondary special, 4 is higher education, W is content of butirylcholinesterase in blood in nmol/s-l. If value P is 16-18, normal regulatory functions are predicted, 12-15 - moderate regulatory dysfunction, lower than 12 - expressed regulatory dysfunction.

EFFECT: method makes it possible to predict degree of impairment of regulatory functions in early terms.

3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine and medical equipment. Circumference, on which a mark and moving point object are placed, is shown on the screen. At the moment of supposed coincidence of the point object with the mark position of the point object with respect to the mark is registered. Error of non-coincidence of the point object and mark positions- time of delay or feedforward error - is calculated. Average value of delay or feedforward errors is determined. Value is taken for assessment of intensity of nervous processes of excitation, Sfeed is mean quadratic deviation of the results of measurements of feedforward errors where xfeed is value of result of feedforward error, is arithmetic mean value of feedforward errors, nfeed is the number of feedforward errors. Value is taken for assessment of intensity of nervous processes of inhibition, with Sdel being mean quadratic deviation of results of measurements of delay errors where xdel is value of result of delay error, is arithmetic mean value of delay errors, ndel is the number of delay errors.

EFFECT: method extends arsenal of means for assessment of intensity of nervous processes.

1 dwg, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine. Electroencephalogram (EEG) is registered in background mode, spectrograms are calculated by means of wavelet conversion with Morlet mother function. Frequency ranges of leading EEG rhythms are determined by finding values of coordinate minimums by frequency of envelope projections of wavelet spectrograms on "amplitude-frequency" coordinate plane. In frequency ranges times Ti of spectrogram peak appearance are determined by values of positions of maximums on envelope projection of wavelet spectrograms. Frequencies Fi and amplitudes Ai of peaks of spectrograms, which correspond to values of times of their appearance in each frequency range, are determined. For each discretisation window with ΔT, ΔF parameters, obtained by fragmentation of duration T and frequency range F of EEG registration, values ΣAi of sums of amplitudes of spectrogram peaks are calculated. If frequency increases, range of frequencies of peaks expands, interhemispheric asymmetry of electric activity is detected, early stage of Parkinson disease is diagnosed.

EFFECT: method makes it possible to increase reliability of determination of early stage of PD.

4 cl, 9 dwg, 1 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to functional diagnostics. Electroencephalogram (EEG) is registered, indices of averaged powers of spectra in background EEG registration in frequency range 8-13 Hz MI before 1up to 16 minute long HF impact and M2 after EHF impact consisting of 6-10 procedures are determined. Dynamics of ratios of said indices of powers M2/M1 presence of compensatory reserves of brain is determined. In case if ratios M2/M1, equal more than 1.2 are present, conclusion about positive dynamics of general functional state of brain an possibility of carrying out standard EHF therapy is made.

EFFECT: method extends arsenal of means for control over state of patient with encephalopathy in EHF therapy.

6 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to field of medical and psychophysiological diagnostics. Assessment of character of motor asymmetries - determination of degree of right-handedness - left-handedness by dominance of hand and leg, as well as sensor asymmetries - determination of leading eye and ear, is performed. Also calculated is coefficient of amplitude and frequency of mu-rhythm in central parts of left and right hemisphere, as ratio of difference of maximal and minimal values to their sum. Difference between maximal and minimal values is calculated within 3-second long interval. Dominating hemisphere of motor cortex by mu-rhythm is registered at the moment of alternate clenching right and left hand fist with application of sensomotor test by scheme: "Close eyes - make right fist - open eyes - undo the fist", "Close eyes - make left fist - open eyes - then undo the fist', during standard registration of electroencephalogram.

EFFECT: method extends arsenal of means for assessment of functional interhemispheric asymmetry.

9 dwg, 4 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to neuroinfections. Assessment of anamnesis data, virological indices, fever reaction and spotty-papular rash appearance is carried out. EEG is additionally registered in the first three days from the moment of admission, leukocyte index of intoxication, presence of mixed hypervirus infection are determined. If hypoxy-ischemic affection of central nervous system, spotty-papular rash on the body from the first day of disease with its "additional appearance" during 5-7 days, fever to 39-40°C during first 3-5 days are present in child's anamnesis, reduction of index of main physiological rhythm less than 30%, increased paroxysmal activity in form of diffuse sharp waves and flashes of slow activity with amplitude more than 100 mcV during 3 days or at least on one of these days are detected on EEG, value of leukocyte index is 0.2-3 conv.units, mixed hyperviruses together with varicella zoster virus, virus of type 6 herpes and/or type I herpes simplex virus are detected, risk of neurological complications is predicted.

EFFECT: method makes it possible to increase reliability of predicting risk of neurological complications in case of chicken pox in children.

3 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine and medical equipment, particularly to methods and apparatuses for scalp electric potential measurement. The apparatus comprises a number of sensors obtaining the initial measurement of a scalp electric potential through a hair-covering and an air contact area; a number of preamplifiers connected to one of the appropriate mentioned sensors. The contact area produces a high and variable coupling impedance of the source and the scalp. Each preamplifier contains a broadband high-impedance input and an active bias circuit generating input impedance more than 10 petaOhm over the range from 0.01 Hz to 400 Hz; a high-gain low-noise operating amplifier with the input impedance of 10 teraOhm; and a shielded feedback and bias circuit. The preamplifier is configured to have the input impedance substantially higher than the impedance produced by the source-sensor contact area. One version of the implementation of the method for scalp electric potential measurement, the preamplifier obtains the initial measurement of the scalp electric potential and forms a pre-intensified measurement of the scalp electric potential. The measurement is taken through the hair-covering and air. In the other version of the implementation of the method, an input signal of the initial scalp electric potential is obtained from the number of sensors to generate an appropriate number of channels. It is followed by the signal pre-amplification by the preamplifier with the high input impedance to form the pre-intensified measurement of the scalp electric potential. Then, a measurement mode is configured in a group containing a channel mode relative to a reference channel, a channel mode relative to a middle channel and a differential interchannel mode. Then, the pre-intensified measurement of the scalp electric potential is biased with maintaining the mentioned high input impedance; a channel gain is adjusted to differential obtaining of the channel signal. An additional stage providing the processed channel signal is suppressing radiofrequency interferences of the channel signal with maintaining adjustment of the gain and the phase; a common-mode of the channel signal is suppressed, and the band-pass channel filtration is provided. The processed channel signal is digitised to present a digital signal of the measurement of the scalp electric potential, characterising the mentioned input signal measured according to the mentioned chosen measurement mode.

EFFECT: use of the group of inventions allows more effective measurements of the scalp electric potential due to the preamplifiers, and allows reducing the need of exfoliating of the necrotic epithelial cells or application of abrasive or conducting gels.

27 cl, 11 dwg

FIELD: medicine.

SUBSTANCE: invention concerns medicine and medical technology. A patient is exposed to electrical stimulation generated by the 'simpaticor-01' apparatus. A one-element electrode is placed in a projection of cervical ganglia, while a multiple-element electrode - on a patient's neck. The exposure to the field is paused. A convulsive readiness threshold is assessed. Neurometabolic preparation dosage is specified in accordance with age, while anticolvulsants are dosed as per manufacturer's recommendations. Amplitude, frequency and length of the current pulse field, length of exposure and pauses are specified individually for each patient so that in the process of treatment and later on, the convulsive readiness threshold tends to decrease in the form of reducing a number of paroxysmal sharp and slow waves, as well as elimination of epileptoid activity.

EFFECT: method provides higher clinical effectiveness ensured by combining drug-induced therapy with electrical stimulation of the vegetative nervous system.

7 dwg, 1 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to oncologic neurosurgery, neurology and functional diagnostics. Electroencephalographic (EEG) examination is carried out. Power of delta-range waves in parietal regions is estimated on EEG. In case of simultaneous increase of power in left parietal region above 80 mcV2 and in right region above 85 mcV2, malignant form of growth of neuroepithelial tumour of III ventricle is diagnosed.

EFFECT: method extends arsenal of means for diagnosing type of growth of neuroepithelial tumours of III brain ventricle.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to oncologic neurosurgery, neurology and functional diagnostics. Estimation of clinical status and neurovisualisation data and EEG examination are carried out in preoperative period. Depending on anatomical-topographical and histological version of tumour, as well as detected clinical-EEG complex of symptoms risk of development of complications in early postoperative period in patients after ablation of tumours of basal-diencephalic localisation is predicted.

EFFECT: method extends arsenal of means for predicting development of complications in early postoperative period in patients with different anatomical-topographical versions of tumours of basal-diencephalic localisation.

3 ex

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to oncologic neurosurgery, neurology and functional diagnostics. Electroencephalographic (EEG) examination is performed. Coherent connections of brain regions, intensity of EEG rhythms in alpha-, beta- and theta- ranges are determined. Taking into account obtained EEG data and in dependence with localisation of tumour position in basal-diencephalic region, degree of functional activity disorder is determined.

EFFECT: method extends arsenal of means for estimation of degree of disorder of cerebral functional activity in patients with tumours of basal-diencephalic region.

1 tbl, 3 ex

FIELD: medicine.

SUBSTANCE: invention relates to filed of medicine, namely to pediatric neurology. Electroencephalographic examination of children's brain is performed in mode of drug-free afternoon sleep in corrected age of one month. In the phase of slow sleep quantity of sigma-spindles per one minute and their duration are determined. If quantity of sigma-spindles equals 2 and lower with duration 1 sec and shorter, formation of ICP in children with extremely low and very low body weight at birth is predicted.

EFFECT: method extends arsenal of means for prediction of formation of infantile cerebral paralysis in children with extremely low and very low body weight at birth.

2 tbl, 4 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to dermatology, pathological physiology and pathological anatomy. Device contains clamp with handles and branches with contact sites. Contact sides of branches are provided with fixed on free ends similar fragments of vertically cut metal tube with diameter, smaller than diameter of cylindrical bioptate, directed with concave surface to each other and extracted bioptate.

EFFECT: invention provides possibility of obtaining cylinder-shaped sample from surface to subcutaneous adipose cellular tissue, hypoderm, including all skin layers, suitable for all types of histological analyses, preserving natural, non-deformed mutual location of layers, cells and intercellular matrix.

3 dwg, 1 ex

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