Compositions for oral cavity care containing amorphous quartz


FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions relates to compositions for oral cavity care and methods of such compositions application. Claimed composition for oral cavity care contains amorphous quartz and source of ions of bivalent tin, with average size of amorphous quartz particles constituting from 1 to 20 microns. Version of composition additionally includes one or more essential oils and chelant. Method of oral cavity care includes stage, at which upper said composition is introduced into subject's oral cavity.

EFFECT: application of amorphous quartz (fuse quartz) as abrasive in mixture of composition for oral cavity care ensures good compatibility with ions of bivalent tin with effective and safe cleaning of dental tissues.

17 cl, 2 ex, 30 dwg

 

The technical field to which the invention relates.

The present invention relates to compositions for the care of mouth cavity containing amorphous silica and a source of ions of divalent tin.

The level of technology

Effective composition for the care of the oral cavity can support and maintain the appearance of your teeth by removing dental stains and polishing the teeth. It can clean and remove outer plaque, which can help prevent tooth decay and improve gum health.

The abrasives in the compositions for the care of the oral cavity to help resolve firmly attached layer of plaque, attached to dental stones. Deposits typically contains a thin acellular glycoprotein-mucoproteins coating adhering to the enamel within minutes after cleaning teeth. The presence of different food pigments inside the plaque causes most of the discoloration of the teeth. The abrasive may remove deposits with a minimum abrasive damage to the tissues of the oral cavity, such as dentin and enamel.

In addition to the clearance may be desirable that the abrasive system provided the polishing of tooth surfaces, because the polished surface may have a greater resistance to ectopic deposition of undesirable components. The appearance of your teeth can be improved PU is eat make polerowanie tooth, since the surface roughness, i.e. its otpolirovannami affects the reflection and scattering of light, which is an integral refers to the appearance of the tooth. The surface roughness also affects the sensation from the tooth. For example, polished teeth gives a feeling of purity, smoothness and Shine.

Numerous compositions money to care for your teeth use of precipitated silica abrasive. Precipitated silicas are marked and described in U.S. patent No. 4,340,583 July 20, 1982, issued by Wason, patent EP 535,943 A1, 7 April 1993, issued by McKeown et al., PCT application WO 92/02454, February 20, 1992, issued by McKeown et al., U.S. patent No. 5,603,920, February 18, 1997, and U.S. patent No. 5,716,601, February 10, 1998, both issued to Rice, and U.S. patent No. 6,740,311, may 25, 2004, issued to White et al.

While providing effective cleaning of the teeth of precipitated silica in the compositions for the care of the oral cavity can have compatibility issues with the main active substances of the composition, such as ions of divalent tin. As shown, such compatibility issues directly related to the surface properties of precipitated silicas, such as surface area, the number of hydroxyl groups and porosity.

There is a need in the abrasive system, which has good compatibility with ions of divalent tin, while providing effective and safe on isdi and polishing of dental tissues. Additionally, there is still a need for abrasives, which can provide excellent cleaning and polishing at a reduced cost. The composition of the amorphous silica and divalent tin in accordance with the present invention can provide one or more of these advantages. The present invention also relates to compositions for the care of the oral cavity and to methods of using such compositions for the care of the oral cavity, which can ensure the best stability of divalent tin.

The invention

Composition for caring for the oral cavity according to the present invention contains an amorphous silica and a source of ions of divalent tin. Ion of divalent tin can be obtained from the fluoride of divalent tin or of the salt of divalent tin selected from the group consisting of chloride divalent tin, ferrous gluconate tin acetate divalent tin tartrate divalent tin oxalate divalent tin, ferrous sulfate tin, citrate divalent tin, malonate divalent tin, ferrous lactate, tin, phosphate divalent tin pyrophosphate divalent tin bromide divalent tin iodide divalent tin and combinations thereof. The number of ions of bivalent tin can make the t about 50 ppm to about 15000 ppm or less than about 10000 ppm.

In one implementation, ions of divalent tin will have compatibility in excess of 80% after two weeks of storage at 25°C before use. In another implementation, compatibility may exceed 90% at 25°C before use.

Composition for the care of mouth cavity containing amorphous silica and a source of ions of divalent tin, may also contain chelant. Chelant may be selected from polymeric organophosphorus compounds, including ethoxylated and methoxylamine mono or dialkylphosphate or phosphonates. Composition for oral care mouth on the basis of divalent tin and amorphous silica may also contain an essential oil, such as an essential oil selected from the group consisting of acyclic and cyclic structures containing loop structures, and combinations thereof. Composition for oral care mouth on the basis of divalent tin and amorphous silica may also contain gel grid, a source of peroxide, a source of zinc ions, or a combination of these materials. Also described is a method of reducing plaque, gingivitis, sensitivity, unpleasant mouth odor, erosion, cavities, plaque, inflammation and staining by introducing into the oral cavity of the subject composition containing amorphous silica and a source of ions of divalent tin.

Brief description of drawings

Feels a table of material properties of various amorphous quartz and precipitated silicas.

FIGURE 2 is a table of data compatibility for amorphous quartz and precipitated silicas.

FIGA is a table of compositions based on sodium fluoride compositions for oral care mouth.

FIGU is a table of the values of PCR and RDA for compositions FIGURE 3(a).

FIGA is a table of compounds based on tin fluoride compositions for oral care mouth.

FIGU is a table of the values of PCR and RDA for compositions 4(a).

FIGURE 5 is a table cleaning and abrasiveness of amorphous quartz.

FIGA-I represent micrograph of scanning electron microscope images of precipitated silica and amorphous silica.

FIGA is a table of the compositions.

FIGU is a compatibility table of divalent tin, zinc and fluoride for songs FIGA.

FIG is a compatibility table of divalent tin as a function of silica loading.

FIGA is a table of compositions containing peroxide and amorphous silica and precipitated silica.

FIGU is a table of compatibility with the peroxide compositions FIGA.

FIGA is a table of compositions containing amorphous quartz.

FIGU is a table x is the new cleaning and bleaching compositions FIGA.

FIGA is a table of compositions containing amorphous silica and precipitated silica.

FIGU is a table of data consumers ' perception compositions FIGA.

FIG is a table of additional examples of the compounds.

FIGA is a table of examples of the compounds.

FIGU is a table of the values of PCR and RDA for compositions based on sodium fluoride FIGA.

FIGS is a table of examples of the compounds.

.13D is a table of RDA values for compositions based fluoride divalent tin FIGS.

Detailed description of the invention

While this description ends with the formula of the present invention, which is specifically described and clearly stated the present invention, suppose that the present invention will be clearer from the following description.

Definition

The term "acceptable oral carrier", as used in this application means a reasonable basis or ingredient that can be used to obtain and/or use of these compositions in the oral cavity a safe and effective manner. This framework can include such substances as sources of fluoride ions, antibacterial agents, agents that prevent the formation of stones, buffers, other AB is asignee substances, sources peroxide, bicarbonate alkali metal salts, thickeners, humectants, water, surfactants, titanium dioxide, system flavoring agents, sweeteners, cooling means, xylitol, coloring agents, other acceptable substances and their mixtures.

The term "comprising"as used in this application means that can be added to the stage and ingredients other than specifically listed. This term encompasses the terms "consisting of" and "consisting essentially of". Compositions in accordance with the present invention may contain, consist of, and essentially consist of the essential elements and limitations of the present invention described in this application, as well as any additional or optional ingredients, components, stages, or limitations described in this application.

The term "effective amount", as used in this application, means an amount of compound or composition sufficient to obtain a useful effect, beneficial effect to the oral health, and/or quantity, low enough to avoid serious side effects, i.e. to ensure a reasonable ratio of benefits and risks within the sound judgment of a person skilled in the technical field.

The term "composition for the care of the oral cavity" as used in this application means a product that is part of the standard application remains in the oral cavity for a time sufficient to contact some or all of the dental surfaces and/or tissues of the oral cavity for oral activity. Composition for the care of the oral cavity in accordance with the present invention can be in various forms, including toothpaste, means for care of teeth, tooth gel, tooth powder, pill, liquid, podlesney gel, foam, mousse, chewing gum, lipstick, sponge, floss, prophylactic paste, vaseline gel or dental prosthesis. Composition for the care of the oral cavity may also be included in strips or films for direct application or joining surfaces of the oral cavity, or included in the floss.

The term "means for the care of teeth," as used in this application means a paste, gel, powder, tablet or liquid composition, unless otherwise indicated, are used for cleaning surfaces of the oral cavity.

The term "teeth", as used in this application refers to natural teeth and artificial teeth and dental prostheses.

The term "polymer"as used in this application should include substances obtained by polymerization of one type of monomer or from two (i.e., copolymers) or more types of monomers.

the Ermin "water-soluble", as used in this application means that the substance is soluble in water in this composition. In General, the substance must be soluble at 25°C at a concentration of 0.1% by weight of an aqueous solvent, preferably at 1%, more preferably at 5%, more preferably at 15%.

The term "phase"as used in this application, means mechanically separate homogeneous part of a heterogeneous system.

The term "essentially no hydrated"as used in this application means that the substance has a low number of surface hydroxyl groups, or is essentially free of surface hydroxyl groups. It may also mean that the substance contains less than about 5% of the total water (free and/or bound).

The term "majority"as used in this application means a greater number or part; number greater than half of the total number.

The term "average"as used in this application means the average value of the distribution, above and below which lie an equal value.

All percentages, parts and ratios are based on the total weight of the compositions in accordance with the present invention, unless otherwise indicated. All such masses as they pertain to listed ingredients are based on the active level and, therefore, not on the given solvents or by-products, which may be included in commercially available materials, unless otherwise noted. The term "mass percent" can be designated as "wt.%" in this proposal.

All molecular weight, as used in this application are average molecular weights, expressed as grams/mol, unless otherwise noted.

Amorphous quartz

Amorphous silica is a high purity amorphous silicon oxide. It is sometimes called fused quartz, quartz glass or sintered glass. Amorphous quartz is a type of glass, which is typical for glasses, has no long-range order in the atomic structure. But optical and thermal properties of amorphous silica are unique compared to other glasses, as amorphous silica typically has greater strength, thermal stability and UV permeability. For this purpose, known as amorphous silica, is used in situations such as semiconductor manufacturing and laboratory equipment.

The present invention uses amorphous silica in the compositions for the care of the oral cavity, in particular in compositions of funds for the care of teeth. While many modern compositions money to care for your teeth use silica as a thickening agent, and abrasive, silicas typically used as precipitated silica. About Ardenne silica receive water by precipitation or drying process. On the contrary, amorphous quartz is typically produced by melting high-purity silica sand at very high temperatures of about 2000°C.

The Figure 1 presents a table of material properties of various types of amorphous quartz. Also shown for comparison are the same physical properties for some of precipitated silicas. Shows some of the key material properties that distinguish amorphous silica precipitated from silica, including BET surface area, loss on drying, loss on ignition, silanol density, bulk density, bulk density, oil absorption and distribution of particle sizes. Each of these material properties discussed in more detail below.

The process of heating the silica to such high temperatures destroys the porosity and surface functional groups of the silica. It receives the silica, which is extremely hard and inert to most substances. The melting process also results in a low surface area BET, less than the BET surface area precipitated silica. The BET surface area amorphous silica is in the range from approximately 1 m2/g to about 50 m2/g, from about 2 m2/g to approximately 20 m2/g, from about 2 m2/g to priblizitel is but 9 m 2/g and from about 2 m2/g to about 5 m2/, For comparison, the precipitated silicas typically have a BET surface area in the range from 30 m2/g to 80 m2/, BET surface Area determined by the method of absorption of nitrogen BET Brunaur et al., /. Am. Chem. Soc, 60, 309 (1938). Cm. also U.S. patent No. 7,255,852, issued August 14, 2007 Gallis.

Amorphous silica, relative to other types of silica, typically contains a small amount of free and/or bound water. The amount of bound and free water in amorphous quartz is typically less than approximately 10%. The amount of bound and free water in amorphous silica may be less than approximately 5%, or less than approximately 3%. The silica containing less than about 5% of bound and free water can be considered as essentially not hydrated. The total amount of bound and free water can be calculated by combining the two measurements, loss on drying (LOD) and loss on ignition (LOI). For loss on drying, which occurs first, the sample may be dried at 105°C for two hours, the weight loss is a free water. For loss on ignition of the dried sample is then heated for one hour at 1000°C, the mass loss is a bound water. The amount of LOD and LOI pre what is the total bound and free water in the original sample. For example, in accordance with the described method of analysis, amorphous quartz (Teco-Sil 44CSS) has a loss on drying 0.1% and loss on ignition of 2.2%, for the amount of 2.3% of the total water. For comparison, a typical precipitated silica, Z-119, has a loss on drying of 6.1% and loss on ignition of 5.1%, for the amount of 11.2% of the total water. (Other methods of analysis, see United States Pharmacopeia-National Formulary (US-NF General Chapter 731, Loss on Drying and US-NF General Chapter 733, Loss on Ingnition.)

Amorphous silica, relative to the precipitated silica has a small number of surface hydroxyl or silanol groups. Calculation of surface hydroxyl groups can be carried out by using the nuclear magnetic resonance (NMR) to measure the silanol density specific silica. Silanol are compounds containing silicon atoms, to which it is directly attached hydroxyl substituents. When performing analysis of the NMR of solids at various silicas signal silicon enhanced by energy transfer from the neighboring protons. The number of reinforcements signal depends on the proximity of silicon atoms to protons of hydroxyl groups located on the surface or very close to it. So silanol density was normalized to the intensity of the silanol signal (intensity/g), is a measure of the concentration of surface hydroc the ilen groups. Silanol density for amorphous quartz may be less than approximately 3000 intensity/g, in some implementations less than approximately 2000 intensity/g, and typically less than approximately 900 intensity/, Amorphous quartz can have an intensity/g, comprising from about 10 to about 800, and typically from about 300 to about 700. For example, the sample of amorphous silica (Teco-Sil 44CSS) has a silanol density 574 intensity/year Typical precipitated silica has more than 3000 intensity/g and typically more than 3500 intensity/, for Example, Huber Z-119 measures 3716 intensity/year Method of analysis silanol density using solid state NMR cross-polarization and rotation under magic angle (5 kHz) and high-energy proton and unleashing spectrometer Varian Unity Plus-200 ultrasonic dual-probe 7 mm from Doty Scientific. The relaxation delay was 4 seconds and the time contact was 3 MS. The number of scans ranged from 8000 to 14000, and the time frame of the experiment was 10-14 hours per sample. The samples were weighed to 0.1 mg for the normalization procedure. Spectra were plotted on the graph in the mode of the absolute intensity and the integrals were obtained in the regime of absolute intensity. Silanol density was measured by drawing on the graph is K and the integration of the spectra in the regime of absolute intensity.

Surface reactivity of silica, representing the relative amount of surface hydroxyl groups can be measured by the ability of silica to adsorb methylene red from the solution. So measure the relative amount of silanols. The analysis is based on the fact that methylene red selectively adsorbed on reactive silanol sites of the surface of the silica. In some implementations, the solution of methylene red after exposure to amorphous silica can have absorption in excess of the absorption solution after exposure to typical precipitated silica. This is because amorphous silica so strongly reacts with a solution of methylene red as precipitated silica. Typically, amorphous quartz will be the absorption of a solution of methylene red 10% higher than the standard of precipitated silica, as precipitated silica is more readily reacts with a solution of methylene red. Absorption can be measured at 470 nm. Ten grams of 0.001% methylene red in benzene is added to a 0.1 grams of each of the two samples of silica and mixed for five minutes on a magnetic stirrer. The resulting suspension is centrifuged for five minutes at 12,000 rpm and then the percent transmission at 470 nm is determined by lackaday samples and average. Cm. "Improving Cationic Compatibility Silica Abrasives Through Use of Topochemical Reactions" from Gary Kelm, Nov. 1, 1974, in Her, Ralph K., Colloid Chemistry of Silica and Silicates, Cornell University Press, Ithaca, N.Y., 1955.

He being bound by theory, believe that amorphous quartz, with its low specific BET surface area, low porosity and a low number of surface hydroxyl groups is less reactive than precipitated silica. Therefore, amorphous silica can adsorb smaller amounts of other components such as fragrances, active ingredients, or cations, which leads to better availability for other components. For example, preparations for the care of teeth, containing amorphous silica, have excellent durability and availability for divalent tin, fluoride, zinc, other cationic antibacterial agents and hydrogen peroxide. Amorphous quartz included in the composition means for care of the teeth, can lead to at least approximately 50%, 60%, 70%, 80% or 90% compatibility with cations or other components. The cation can be a source of ions of divalent tin.

The Figure 2 shows the compatibility of divalent tin and fluoride various types of amorphous silica and precipitated silica. Compatibility of divalent tin and fluoride is determined by adding 15% of silica in the mixture of sorbitol/water containing 0.6% of gluco the ATA sodium and 0,454% fluoride divalent tin and good mixing. Each sample silica suspension is then placed on stability at 40°C for 14 days, and then analyzed by divalent tin and fluoride. The measurement of the concentration of soluble divalent tin and soluble zinc under normal conditions brushing brush may be as follows: prepare a suspension of 3:1 water and means for care of teeth (silica) and centrifuge it to highlight the transparent layer of the supernatant liquid. Dilute the supernatant in an acidic environment (nitric or hydrochloric acid) and analyze by means of optical emission spectrometry with inductively coupled plasma. The percentage of compatibility calculated by subtracting analyzed from the initial values. The measurement of the concentration of soluble fluoride under normal conditions brushing brush may be as follows: prepare a suspension of 3:1 water and means for care of teeth (silica) and centrifuge it to highlight the transparent layer of the supernatant liquid. The supernatant analyzed for fluoride using a fluoride electrode (after mixing 1:1 with buffer TISAB) or dilute hydroxide solution and analyzed by ion chromatography with conductivity detection. The percentage of compatibility calculated by subtracting analyzed from the initial values. In General, cationic shall sovmestimosti you can define "% CPC compatibility test", described in U.S. patent 7255852.

There are numerous other characteristic differences between amorphous silica and precipitated silica, in addition to compatibility and concentration of surface hydroxyl groups. For example, amorphous quartz is more dense and less porous. Volumetric porosity of amorphous quartz is typically greater than 0.45 g/ml and can range from approximately 0.45 g/ml to about 0,80 g/ml, while the volume density of precipitated silica is not more than about 0.40 g/ml bulk density amorphous silica is typically greater than 0.6 g/ml, and may be from about 0.8 g/ml to about 1.30 grams/ml, while the bulk density of precipitated silica is not more than 0.55 g/ml Bulk density and bulk density can be measured by the following methods in USP-NF, General Chapter 616, Bulk density and Tapped Density. For bulk density can be used in the method 1, the measurement in a graduated cylinder; for bulk density, can be used method 2, using a mechanical filling. Bulk density and bulk density are the ratio of mass to volume of the particles (many particles in a given volume) and display the captured air, the porosity and the way in which particles are mutually in this volume. True or self is I the density of the particles (the ratio of the mass to the volume of one particle) for amorphous silica is from about 2.1 g/cm 3to 2.2 g/cm3, while the true or own the density of precipitated silica is not more than about 2.0 g/cm3. Similarly, the specific gravity of amorphous quartz can range from approximately 2.1 to 2.2, while the unit weight of precipitated silicas may be no more than approximately 2.0. The difference in density can have a significant impact during production funds for the care of teeth, for example, where a higher density of amorphous quartz reduces or removes the stage of processing or de-aeration, which can lead to the reduction of periods of the periodic cycles.

Amorphous silica has a relatively low absorption of water and oil, the measurements are well correlated with the specific surface area BET. The water absorption for amorphous silica, meaning the amount of water that it can absorb while maintaining the homogeneity of the powder is less than about 80 g/100 g, optionally less than about 70 g/100 g, about 60 g/100 g, or about 50 g/100 g water Absorption for amorphous silica may be even lower, in the range of less than about 40 g/100 g, optionally less than about 30 g/100 g, and can range from about 2 g/100 g to approximately 30 g/100 g For precipitated silicas absorption in the water is typically about 90 g/100 g The water absorption is measured by J.M Huber Corp. The standard evaluation method, S.E.M No.5,140, August 10, 2004. Absorption oil for amorphous silica is less than approximately 75 ml of dibutyl phthalate/100 g of amorphous silica, and may be less than approximately 60 ml of dibutyl phthalate/100 g of amorphous quartz. Absorption oil may be in the range from approximately 10 ml of dibutyl phthalate/100 g of amorphous silica to about 50 ml of dibutyl phthalate/100 g of amorphous silica and may be the desired value from approximately 15 ml of dibutyl phthalate/100 g of amorphous silica to about 45 ml of dibutyl phthalate/100 g of amorphous quartz. For precipitated silicas absorption oil is typically about 100 ml of dibutyl phthalate/100 g of precipitated silica. (The oil absorption was measured in accordance with the method described in patent application U.S. 2007/0001037 A1, published January 4, 2007

Given the relatively low water absorption amorphous silica may be a suspension during processing, ultimately enabling faster processing and less time periodic cycles. In General, to create a suspension of precipitated silica typically requires at least about 50% water. Therefore, it is not practical to use a suspension of precipitated silica in the manufacture of compositions for the care of what olotu mouth. But due to inertia or lack of porosity of amorphous silica, which leads to relatively low water absorption amorphous silica can be obtained suspension of amorphous silica, in which water is less than approximately 30% in some realizations, or less than 40% in some implementations. Some implementation may be a method of obtaining a composition for the care of the oral cavity, comprising adding a suspension of amorphous quartz. In some implementations, the suspension of amorphous silica contains a binder. This may contribute to the preservation of amorphous silica suspended in the suspension, especially with large amounts of water. It can also provide a binder substance more time for operations. In some implementations binder selected from the group consisting of carboxyvinyl polymers, carrageenan, hydroxyethyl cellulose, water soluble salts of cellulose ethers such as sodium carboxymethylcellulose, cross-linked carboxymethylcellulose, sodium hydroxyethylcellulose, cross-linked starch, natural gums such as gum karaya, xanthan gum, gum Arabic and tragacanth gum, magnesium aluminum silicate, silica, alkyl polyacrylates, cross-alkyl-school is mentioned polyacrylates and mixtures thereof. Suspension of amorphous silica can be pre-mixed. In some implementations, the suspension of amorphous silica can be flowing or pumped. In some implementations, the suspension of amorphous silica may optionally contain a preservative such as benzoic acid, sodium benzoate, sorbic acid or parabens, which can be used when less than approximately 1%.

Amorphous silica typically has a much lower conductivity than the precipitated silica. Conductivity is an indirect measure of dissolved electrolytes and precipitated silica can not be obtained without obtaining soluble electrolytes. Thus, while the conductivity of the precipitated silica is in the range of about 900-1600 the s/cm (based on 5% dispersion in deionized water), the conductivity of the amorphous silica is less than about 10 s/cm (measurement performed using a table of conductivity meter Orion 3, available from Thermo Electron Corporation).

The pH of the amorphous silica may be in the range of from about 5 to about 8, while the pH of the precipitated silica is typically from about 7 to about 8. The pH value is determined according to patent application U.S. 2007/0001037 A1, published January 4, 2007

The refractive index, the measure of light transmittance, typically, higher for amorphous silica than for precipitated silica. Placed in a mixture of sorbitol/water, amorphous silica has a refractive index of at least approximately 1.45, while the precipitated silicas have a refractive index from 1.44MB to 1,448. A higher refractive index may allow more light receiving transparent gels. The refractive index determined using the method described in patent application U.S. 2006/0110307 A1, published may 25, 2006

Amorphous silica typically has a hardness of ISCU in excess of approximately 6 greater than approximately 6.5 and greater than about 7. Precipitated silica is not so rigid, typically have a hardness of ISCU is 5.5-6.

Another difference between amorphous silica and precipitated silica is clean, with amorphous silica has a higher purity than the precipitated silica. The percentage of silica, by weight, of amorphous silica can be more than about 97%, about 97.5%, about 98%, about 98.5 per cent, in some implementations exceed approximately 99%, and in some implementations to exceed an estimated 99.5%. For precipitated silica, the percentage of silica, by weight, is typically only about 90%. Such measurement of the purity of clucalc water as an impurity, and can be calculated using LOD and LOI ways described earlier.

Depending on the provider, impurities other than water, may include ions and metal salts, among other substances. In General, precipitated silicas, impurities other than water, are mainly sodium sulfate. Precipitated silica will typically contain from about 0.5% to 2.0% of sodium sulfate. Amorphous quartz typically contains sodium sulfate or contains less than 0.4%. The levels of purity, not including water, can be determined by reference to USP-NF Dental Silica Silicon Monograph, as follows: purity is the combined results of the analysis (silicon dioxide) and tests on sodium sulfate. For analysis, transfer about 1 g of gel crimetime in weighed platinum dish, proclivity at 1000°C for 1 hour, cool in a drying oven and weigh. Gently spray with water and add approximately 10 ml of hydrofluoric acid in small portions. Isparate on the steam bath until the solids and refrigerate. Add approximately 10 ml of hydrofluoric acid and about 0.5 ml of sulfuric acid and isparate to the dry residue. Slowly raise the temperature to volatilisation of all acids and proclivity at 1000°C. Cool in a drying oven and weigh. The difference between the final weight and weight of the original calcined portion represents the mass of SiO2. Sul the veils of sodium transfer about 1 g of silica, dental type, accurately weigh, in a platinum dish, moisten with a few drops of water, add 15 ml of perchloric acid and place the dishes on a hot stove. Add 10 ml of hydrofluoric acid. Heat before the formation of abundant foam. Add 5 ml of hydrofluoric acid and heat again before the formation of abundant foam. Add approximately 5 ml of boric acid solution (1 in 25) and heat until foaming. Cool and transfer the precipitate in the beaker 400 ml using 10 ml of hydrochloric acid. Dilute with water to approximately 300 ml and bring to a boil on a hot plate. Add 20 ml of hot barium chloride TS. Keep the beaker on a hot plate for 2 hours, keeping the volume of approximately 200 ml After cooling, transfer the precipitate and the solution is dried in a weighed crucible with a filter with a porosity of 0.8 μm. Wash the filter and set yourselves in array 8 times with hot water, dry the crucible at 105°C for 1 hour, and weigh. Mass multiplied by 0,6085 represents the content of sodium sulfate in one sample. Found not more than 4.0%. Purity can also be determined by standard analytical techniques such as atomic absorption spectroscopy or by means of elemental analysis.

The unique surface morphology of amorphous silica can prospect is led to a more favorable ratio of PCR/RDA. The efficiency of plaque removal (PCR) amorphous silica in accordance with the present invention, which is a measure of the cleansing characteristics of the means for care of the teeth is in the range from about 70 to about 200 and preferably from about 80 to about 200. Abrasive wear of dentin by radioactive method (RDA) of silica in accordance with the present invention, which is a measure of the abrasiveness of amorphous silica include means for care of teeth is less than about 250, and may be in the range of from about 100 to about 230.

Figure 3A shows the composition of compositions based on sodium fluoride containing various amorphous quartz and precipitated silica. Figure 3B shows the corresponding values of PCR and RDA. Figure 4A shows the composition of compositions based fluoride divalent tin containing various amorphous quartz and precipitated silica. Figure 4B shows the corresponding values of PCR and RDA. The values of the PCR was determined using the method discussed in "In Vitro Removal of Stain with Dentifrice," ..Stookey, et al., J Dental Res., 61, 1236-9, 1982. The RDA values were determined in accordance with the method described in Hefferren, Journal of Dental Research, July-August 1976, p.563-573 and described in Wason, U.S. patent No. 4340583, 4420312 and 4421527. The RDA values can also be defined PR is using the process recommended ADA to determine the abrasiveness of the funds for the care of teeth. The ratio of PCR/RDA amorphous silica, if it is included in the means to care for your teeth, can exceed 1, which indicates that the remedy for teeth provides effective cleaning of plaque without excessive abrasiveness. The ratio of PCR/RDA may be at least about 0.5. The ratio of PCR/RDA is a function of particle size, shape, structure, hardness and concentration.

The Figure 5 presents the data table PCR and RDA for various amounts of silica as amorphous silica, and precipitated silica. It is demonstrated that amorphous silica (TS10 and TS44CSS) can have excellent cleaning ability (PCR) in comparison with the deposited silica (Z119 and Z109). Data show that the composition for the care of the oral cavity with 5% amorphous silica can clean better than a composition for the care of the oral cavity with 10% precipitated silica. Additionally, the data show that amorphous silica can provide treatment while maintaining acceptable levels of abrasivity (RDA).

The shape of the particles of amorphous silica can be classified as acute or spherical, or a combination of forms, depending on the type of production process. Additionally, amorphous silica can also be crushed to reduce the Oia particle sizes. Spherical particles include any particles, where a particle has almost completely rounded or elliptical shape. Sharp particles include any particles that are not spherical, including polyhedral shape. Sharp particles may have a slightly rounded edges, some or all of the sharp edges, some or all of the jagged edges, or a combination of both. The shape of the particles of amorphous silica can affect the abrasiveness. For example, if the same particle size, spherical amorphous silica may have a lower abrasion of dentin by radioactive method (RDA)than RDA acute-angled amorphous silica. Therefore, it may be possible to optimize the cleaning ability, at the same time not increasing the abrasiveness. Or, as another example, preventive pasta or pasta for weekly use may contain sharp amorphous silica with a large particle size.

Compositions containing spherical amorphous silica, i.e., where at least 25% of particles of amorphous silica are spherical, have certain advantages. Because of the rounded edges of the spherical amorphous silica may be less abrasive. This means that the ratio of PCR and RDA can be improved, at the same time providing a good cleaning. Also, spherical amorphous silica can be is used at higher levels, without being too abrasive. Spherical amorphous silica can also be used in combination with the acute-angled amorphous quartz or quartz, where at least about 25% of the particles are acute-angled. This can help reduce costs while providing good cleaning with acceptable abrasion. In implementations that are as sharp and spherical amorphous silica, the number of acute-angled amorphous silica may be from about 1% to about 10%, by weight of the composition. In some implementations where at least 25% of particles of amorphous silica are spherical, RDA may be less than 150, in other implementations less than 120. In some implementations, where at least 25% of particles of amorphous silica are spherical, the ratio of PCR to RDA may be at least approximately 0.7, at least about 0.8, at least approximately to 0.9, or at least approximately 1.0. In some such implementations, the average particle size of the amorphous silica is from about 3.0 microns to about 15,0 ám.

Examples of spherical amorphous quartz include Spheron P1500 and Spheron N-2000R made Japanese Glass Company, and Sun-Sil 130NP.

It is important that the particles of amorphous silica, in General, do not form h is so much aggregated clusters, as precipitated silica and typically do not form aggregated clusters as easy as precipitated silica. In some implementations the majority of the particles of amorphous silica does not form aggregated clusters. On the contrary, precipitated silica, in General, form aggregated clusters of submicron primary particles of irregular shape. The precipitated silica may be treated or coated, which can increase or decrease the amount of aggregation. The shape of the particles as amorphous silica, and precipitated silica can be determined by using scanning electron microscope (SEM).

In Figures 6, A-I, shows the SEM micrograph of precipitated silica and amorphous quartz at magnification of 3000×. Samples were coated with gold using a chilled napylitel Peltier EMS575X. The SEM image of the sample surface were obtained using a JEOL JSM-6100. SEM operated at 20 kV, 14 mm WD and increase H and H.

Micrographs A and B, precipitated silicas Z-109 and Z-119 show agglomerated particles of irregular shape. Particles, apparently made of agglomerated fine particles, loosely Packed together. Micrographs C and D, which are amorphous quartz Spheron P1500 and Spheron N-2000R, show spheroid particles of regular shape. That is, each particle, for the most part is, has the shape of a sphere. And microphotographs E, F, G, H and I, which are amorphous quartz 325F, RG5, RST 2500 DSO, Teco-Sil 44C and Teco-Sil 44CSS show dense particles of irregular shape. Some particles may be agglomerated, tightly Packed, while the other seems to consist of a single mass. In General, this last set of amorphous quartz has particles of irregular shape with defined and/or sharp edges, and they can be considered sharp.

In General, compositions for the care of the oral cavity, for example a means for care of teeth, containing amorphous silica, can be distinguished from compositions for the care of the oral cavity, containing only precipitated silica by heating both of the songs to ash at approximately 500°C and comparison samples. Heated to approximately 500°C leaves only abrasive, but this is not enough to remove hydroxyl groups. Amorphous silica and precipitated silica can be distinguished by analyzing the surface area BET or SEM analysis, as described above, or by analysis of XRD (x-ray scattering).

The average particle size of amorphous quartz in accordance with the present invention may be in the range from about 1 micron to about 20 microns, from about 1 micron to about 15 microns, from about 2 microns d is approximately 12 microns, from about 3 microns to about 10 microns as measured using a distribution of particle sizes laser light scattering, Malvern. Particles of the acute-angled shape may have a particle size (average D50) from about 5 to about 10 microns. Preferably, the D90 (the average size of 90% of the particles) is less than approximately 50 microns, less than about 40 microns, less than about 30 microns, or less than about 25 microns. The small particle size of the amorphous silica can give the advantage of sensitivity, since the particles can block the opening of the tubules. Particle size is determined by the methods described in patent application U.S. 2007/0001037 A1, published January 4, 2007

The particle size of amorphous silica can be controlled by processing of the material. Precipitated silica will be sized depending on the deposition method. While the particle size of some precipitated silicas overlaps with the particle size of amorphous silica, typically precipitated silica will have a larger particle size. For example, precipitated silica Z-109 and Z-119 are in the range of from about 6 microns to about 12 microns, and from about 6 microns to about 14 microns, respectively. But it is important to note that if, for example, amorphous is silica and precipitated silica have the same particle size, the BET surface area amorphous quartz is typically still considerably lower than the BET surface area precipitated Kremnev due to the lack of porosity of the particles of amorphous silica. Thus, the amorphous silica having a particle size similar to the besieged silica, will be different from precipitated silica and offer superior cleaning and/or compatibility compared to precipitated silica.

In some implementations, the particle size of amorphous silica can be optimized for cleaning. In some realizations, the average particle size of the amorphous silica may be from about 3 microns to about 15 microns, where 90% of the particles have a particle size of about 50 microns or less. In other implementations, the average particle size may be from about 5 microns to about 10 microns, with 90% of the particles have a particle size of about 30 microns or less. In other implementations, the average particle size may range from approximately 5 microns to 10 microns, with 90% of the particles have a particle size of about 15 microns or less.

The fact that amorphous quartz is harder precipitated silica, contributes to its ability to better cleaning. This means that amorphous silica with the same particle size and t the m same number, as precipitated silica, will be cleaned relatively better. For example, PCR for the composition of the amorphous silica may, at least about 10% to exceed PCR for the composition of precipitated silica, if the average particle size and the levels of silica similar.

Superior cleaning capabilities amorphous silica leads to various possibilities of compositions, some of them consist in maximizing treatment, some of them consist in improving treatment, in the absence of increasing abrasiveness, some of them are improved cleaning, decreasing abrasiveness, or some songs that are simply more cost effective due to less abrasiveness required to provide acceptable cleaning. In some implementations, the composition for the care of mouth cavity containing abrasive amorphous silica may have a PCR of at least about 80, at least about 100, or at least about 120. In some implementations, the ratio of PCR to RDA may be at least approximately 0.6, at least approximately 0.7, at least about 0.8, or at least approximately to 0.9. In some implementations, the composition may contain less than about 20% amorphous silica, by weight of the composition. In some implementation, the, the composition may contain less than about 15% amorphous silica, by weight of the composition, and to have a PCR of at least about 100, or may contain less than about 10% of amorphous silica, by weight of the composition, and to have a PCR of at least approximately 100.

In some implementations, optimized for superior cleaning at least about 80% of particles of amorphous silica can be acute-angled. In other implementations, the composition may further comprise precipitated silica. In yet some implementations, the composition may contain a gel mesh. In some implementations, the composition may contain one or more of: the action of anti-caries assets, erosion, Antibacterials, means to prevent the formation of dental stones, funds from high sensitivity, anti-inflammatory agent, anti-plaque, funds from gingivitis, funds from unpleasant odor and/or funds from stains. In some implementations, the composition may contain additional abrasive material, including, but not limited to the above, precipitated silica, calcium carbonate, dicalcium phosphate dihydrate, calcium phosphate, perlite, pumice, calcium pyrophosphate, nanodiamonds, surface treated and digidrirovanny osai the military silica and mixtures thereof. Some exercise can be a way to clean the teeth and oral cavity of the subject by applying a composition for caring for the oral cavity containing abrasive amorphous silica in an acceptable oral carrier, where the abrasive amorphous silica has an average particle size of from about 3 microns to about 15 microns, and where 90% of the particles have a particle size of about 50 microns or less.

In some implementations, the particle size of amorphous silica can be reduced to obtain a polishing and protivookislitelnym advantages. In some implementations, the amorphous silica may have an average particle size of about 0.25 microns to about 5.0 microns, from about 2.0 microns to about 4.0 microns, or from about 1.0 micron to about 2.5 microns. In some realizations, 10% of particles of amorphous silica may have a particle size of about 2.0 microns or less. In some implementations, 90% of the particles of amorphous silica may have a particle size of about 4.0 microns or less. In some implementations, the particles can have an average particle size which does not exceed the average diameter of the root canal of a mammal, so that one or more particles are able to enter the channel, thus the m affecting the reduction or elimination of the perceived sensitivity of the teeth. Tooth canals are structures that extend the overall thickness of dentin and form in the mechanism of the formation of dentin. From the outer surface of the dentin in the region near the pulp, such channels are S-shaped. The diameter and density of channels the most about pulp. Gradually tapering from the inside to the outer surface, they have a diameter of about 2.5 microns pulp, 1.2 microns inside the dentin and 0.9 microns in dentinal enamel junction. Their density ranges from 59000 to 76000 per square millimeter to about pulp, while the density is only half and not more than about enamel.

To enhance protivookislitelnym advantages of small size particles, the composition can optionally contain additional protivocesterne agents, such as, for example, agents that block the channels, and/or sensitivity. Agents that block the channels, can be selected from the group consisting of an ion source of divalent tin, strontium ion source, the source of calcium ion, the ion source of phosphorus, a source of aluminum ion, the ion source of magnesium, amino acids, biotical, nanoparticles, polycarboxylates, the gantry and mixtures thereof. Amino acids can be basic amino acids and basic amino acid may be arginine. The nanoparticles can be selected from the group consisting of nanocerox petite, the nanodioxide titanium, nanooxide metals and mixtures thereof. Remedy sensitivity may be a potassium salt which is selected from the group consisting of potassium fluoride, potassium citrate, potassium nitrate, potassium chloride and mixtures thereof. Some exercise can be a way to reduce hypersensitivity of the teeth by introducing the subject, which needs compositions for the care of mouth cavity containing amorphous silica, where the amorphous silica has an average particle size of from 0.25 micron to about 5.0 microns. Some implementation may provide a method of polishing teeth by introducing to the subject a composition for caring for the oral cavity containing amorphous silica, where the amorphous silica has an average particle size of 0.25 microns to about 5.0 microns.

In other implementations, the particle size may be relatively large to be included in the pastes or some other pastes for neededing application. In some implementations, the amorphous silica may have an average size of particles constituting at least about 7 microns, and where the composition has a PCR of at least approximately 100. In other implementations, the average particle size may be from about 7 microns to about 20 microns. In some implementations, if Regni particle size is at least about 7 microns, can be used for more abrasive, which is selected from the group consisting of pumice, perlite, precipitated silica, calcium carbonate, silica rice husk, gels, silica, alum, phosphates, including orthophosphate, polymetaphosphate, pyrophosphates, other inorganic particles, and mixtures thereof. In implementations with large particle sizes, the amorphous silica may be from about 1% to about 10%, by weight of the composition. Some implementation may be essentially free of surfactants, fluoride or any of the active substance to care for the oral cavity. Some implementation may contain flavouring substance. Some of the implementation are ways of cleaning and polishing tooth enamel, including composition for the care of the oral cavity, where the average particle size is at least about 7 microns, and the composition has a PCR of at least approximately 100.

Amorphous silica can be obtained by melting silica (quartz or sand) at 2000°C. After cooling, the ingots or pellets, the material is crushed. Methods of grinding vary, but some examples include jet milling, grinding grinding or ball milling. Ball grinding can lead to b the more rounded edges of the particles, while jet grinding can lead to more acute or acute-angled edges. Amorphous silica can be obtained using the method described in U.S. patent No. 5,004,488, Mehrotra and Barker, 1991. Amorphous silica can also be obtained from enriched silicon chemical precursor, usually using continuous hydrolysis in flames, including chemical gasification of silicon, oxidation of this gas to silicon dioxide and thermal fusion of the resulting dust. In this way can be obtained spherical amorphous silica, but it may be more expensive. While obtaining precipitated silica is a chemical process, obtaining amorphous silica is a natural process. Upon receipt of amorphous quartz, produce less waste and are offered the best advantages of stability.

In some implementations in accordance with the present invention, there can be many types of amorphous quartz. For example, amorphous silica can be obtained by melting silica at higher temperatures, such as 4000°C. Such amorphous quartz may have a different particle size or morphology of the surface, but still retain the advantages discussed above, including low reactivity, due to the relatively low surface concentration is set hydroxyl groups and/or low specific surface area BET.

Precipitated or hydrated silica can be obtained by dissolving silica (sand) using sodium hydroxide and precipitation by adding sulfuric acid. After washing and drying the material is then milled. Such precipitated silica can be obtained by the process described in U.S. patent No. 6,740,311, White, 2004, Besieged and other silicas are described in more detail in Handbook of Porous Solids, edited by Ferdi Schuth, Kenneth S.W.Sing and Jens Weitkamp, chapter 4.7.1.1.1, called Formation Silica Sols, Gels, and Powders, and Cosmetic Properties and Structure of Fine-Particle Synthetic Precipitated Silica, S.K.Wason, Journal of Soc. Cosmetic Chem., vol.29, (1978), p.497-521.

The amount of amorphous silica used in the present invention, may range from approximately 1%, 2%, 5%, 7%, 10%, 12%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50% to approximately 5%, 7%, 10%, 12%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, or 70%, or any combination. Amorphous crystals in accordance with the present invention can be used alone or with other abrasives. The composition may contain more than one type of amorphous quartz. One type of abrasive that can be used with amorphous silica is precipitated silica. The total amount of abrasive in the compositions described in this application, in General, is present at a level from about 5% to about 70%, by weight of the composition. Preferably, compositions of funds for care of the teeth which contain from about 5% to about 50% of the total number of abrasive, by weight of the composition. For combinations of amorphous silica with besieged by silica amorphous silica may be from about 1% to about 99%, by weight of the total quantity of abrasive. Precipitated silica or silica may be from about 1% to about 99% by weight of the total quantity of abrasive. In some implementations, can be used a small amount of amorphous silica, from about 1% to about 10%, or from about 2% to about 5%.

Amorphous silica can be used in combination with inorganic particles, which were treated with non-ionic surfactants, such as ethoxylated and methoxylamine fatty alcohols, acids and esters. One example of such a nonionic surfactant is PEG-40 hydrogensource castor oil. In General, compositions for the care of the oral cavity in accordance with the present invention can be used with additional abrasive material, such as one or more selected from the group consisting of precipitated silica, calcium carbonate, silica rice husk, gels, silica, alum, aluminium silicates, phosphates, including orthophosphate, polymetaphosphate, pyrophosphates, other inorganic particles, dicalcium phosphate dehydr is t, calcium phosphate, perlite, pumice, calcium pyrophosphate, nanodiamonds, surface-treated and digidrirovanny precipitated silica and mixtures thereof.

In some implementations, the ratio of other abrasive amorphous silica in excess of approximately 2 to 1, in some implementations exceeds approximately 10 to 1. In some implementations, the ratio is approximately 1 to 1. In some implementations, the amount of amorphous silica, by weight of the composition, is from about 1% to about 10%. In some implementations, the amount of amorphous silica, by weight of the abrasive combination is from about 2% to about 25%. In one implementation, other abrasive is calcium carbonate. In some implementations, the amount of calcium carbonate, by weight of the composition, is from about 20% to about 60%. In some implementations, the amount of calcium carbonate, by weight of the composition, is from about 20% to about 60%. In another implementation, additional abrasive may contain at least one precipitated silica. The abrasive precipitated silica may contain from about 5% to about 40%, by weight of the combination. The amount of amorphous silica in abrasive combination may be from about 1% to p is blithedale 10%, by weight of the composition. In some implementations, the composition comprising abrasive combination, may have a PCR of at least about 80, about 100, or about 120, or RDA of less than about 150 or less than approximately 200.

To further enhance cation availability in the compositions of amorphous crystals in accordance with the present invention can be used in combination with the treated precipitated by silica, such as surface-modified precipitated silica, digidrirovanny precipitated silica or precipitated silica with reduced porosity, reduced number of surface hydroxyl groups, or a smaller surface area, which are cationic best compatibility compared to conventional besieged by silica. But we emphasize that such specific precipitated silica are treated surface in an attempt to reduce the number of surface hydroxyl groups and to improve properties such as low porosity or cationic compatibility, but they continue to be regarded as precipitated silica. (See, for example, US 7,255,852, US 7,438,895, WO 9323007 and WO 9406868) To have, they are the silicas obtained by the wet method. Water is added in the production process and then later removed. It remains the rule is effective, even in the case of precipitated silica, which can be heated to very high temperatures in an attempt to remove hydroxyl groups. On the contrary, amorphous quartz, although it can, but does not require surface treatment or processing. Amorphous silica is produced without water, only by heating. This heating process can more effectively reduce the number of hydroxyl groups than most of the processes of deposition.

Other abrasive polishing materials may include silica gels, silica rice husk, alum, phosphates, including orthophosphate, polymetaphosphate and pyrophosphates and mixtures thereof. Specific examples include dicalcium phosphate dehydrate, calcium pyrophosphate, tricalcium phosphate, polymetaphosphate calcium, insoluble polymetaphosphate calcium hydrated alum, beta calcium pyrophosphate, calcium carbonate, and resinous abrasive materials such as condensation products of particles of urea and formaldehyde, and others such as described by Cooley et al in U.S. patent 3,070,510, issued December 25, 1962

The abrasive can be precipitated silica or silica gels such as the silica xerogels described in Pader et al., U.S. patent 3,538,230, issued March 2, 1970, and DiGinlio, U.S. patent 3,862,307, issued January 21, 1975, Examples are silica xerogels, which are sold under tor the new name "Syloid" W.R.Grace & Company, Davison Chemical Division. There are also precipitated silica materials such that sell J.M.Huber Corporation under the trade name, "Zeodent", in particular silica, entitled "Zeodent 109" (Z-109) and "Zeodent 119" (Z-119). Other precipitated silica commercially available and comparable with Z-109 and Z-119 include, for example, Tixosil 63, Tixosil Tixosil 73 and 103, all produced by Rhodia, Huber silica Z-103 Z-113 and Z-124, OSC DA produced by the OSC in Taiwan, and ABSIL-200 and ABSIL-NA produced Madhu Silica. Of these commercially available precipitated silicas, Tixosil 73 is the most similar to the Z-119. Present the abrasive precipitated silica can be used in combination with an amorphous quartz and other abrasives.

Types of dental abrasive precipitated silica, which can be mixed with amorphous silica in accordance with the present invention, described in more detail in the Wason, U.S. patent 4,340,583, issued July 29, 1982, the Abrasive precipitated silica is also described in Rice, the U.S. patent 5,589,160; 5,603,920; 5,651,958; 5,658,553; and 5,716,601.

One acceptable type amorphous quartz is Teco-Sil 44CSS, available from C-E Minerals Products. Also available from C-E Minerals Products are amorphous quartz called Teco-Sil 44C, Teco-Sil T10 and TecoSpere A. Other acceptable amorphous quartz include R61000 available from Jiangsu Kaida Silica, and Spheron N-2000R and Spheron P1500 available from JGC, Japanese Glass Company. Others include RST RG 2500 1500 and RG 5, available from Lianyungang Ristar Electronic Materials, SO-C5 and SO-C4, available from Adamatech, Fuserex AS-1, available from Tatsumori, FS-30 and FS-2DC, available from Denki Depending Kogyou, Min-Sil 325F, available from Minco, and Sunsil-130NP, available from Sunjin, and amorphous silica from Shin-Etsu.

CAS No. for certain types of amorphous silica - 60676-86-0. CAS No. for hydrated silica - 7631-86-9. INCI name for amorphous silica is amorphous silica", while the INCI name for precipitated silicas is "hydrated silica". The silicas in accordance with the present invention do not include silicates and amorphous crystals in accordance with the present invention do not include amorphous silicates.

Ion of divalent tin

Compositions for the care of the oral cavity in accordance with the present invention may contain a source of ions of divalent tin. As indicated above, one of the advantages of amorphous silica is its compatibility with other substances, especially substances that are reactive and can lose effectiveness. Ions of divalent tin is considered as a reactive so that the use of ions of bivalent tin with amorphous silica can have several important benefits. Since amorphous silica does not react with the divalent tin in the same degree as precipitated silica and other conventional abrasives, the smaller the number the of divalent tin may be applied, but resulting in the same performance or even better efficiency. Reported that divalent tin can have potential negative aesthetic properties, for example, unpleasant or strong taste, astringent properties, staining, or other negative aesthetic properties, which makes the composition for the care of mouth cavity containing bivalent tin, less desirable to consumers. Therefore, the use of a smaller quantity of divalent tin may be preferred. Additionally, the use of a smaller quantity of divalent tin for the same or similar efficiency (as a composition containing precipitated silica) is economical and can be improved aesthetic characteristics and less staining. Alternatively, when using the same amount of divalent tin, as used traditionally, divalent tin will have a higher efficiency because it is more affordable to provide a useful effect. Since amorphous silica little harder than traditional abrasives such as precipitated silica, amorphous silica can also remove more stains and/or better clean. It was also discovered that compositions containing bivalent tin, can enhance the strength of teeth. Therefore, compositions containing the s divalent tin, can have smaller values of RDA than a comparable composition not containing divalent tin. Smaller values of RDA can provide the best value for PCR and RDA as amorphous quartz is a good cleaning abrasive and divalent tin provides a more strong teeth. The synergy provided by a combination of amorphous silica and divalent tin provides a more efficient visocosity structure for users.

Synergy between amorphous silica and ions of divalent tin can provide many advantages in compositions for oral care mouth for consumers. Low BET surface area, low number of surface hydroxyl groups and low porosity of amorphous quartz makes it acceptable for abrasive compositions containing bivalent tin.

Ions of divalent tin can be provided from fluoride divalent tin and/or other salts of divalent tin. Fluoride divalent tin was found, contributes to the reduction of gingivitis, plaque, sensitivity, erosion, inflammation, and has a useful effect for better breathing. Ions of divalent tin is provided in a composition means for care of the teeth and ensure the effectiveness of the entity that applies the composition of the preparations for the care of teeth. Although the effectiveness may include the useful effects, other than the reduction of gingivitis, efficiency and as a significant amount of reduction in the metabolism of plaque in situ. Compositions which provide such efficiency, typically contain levels of divalent tin, secured by a fluoride of divalent tin and/or other salts of divalent tin in the range of from about 50 ppm to about 15000 ppm divalent ions of tin in the whole composition. Ion of divalent tin is present in an amount of from about 1000 ppm to about 10000 ppm, in one implementation from about 3000 ppm to about 7500 ppm. Other salts of divalent tin include organic carboxylates of divalent tin, such as the acetate of divalent tin, ferrous gluconate tin oxalate divalent tin, malonate divalent tin, citrate divalent tin, etilenglikolem divalent tin formate divalent tin, ferrous sulfate tin, lactate divalent tin tartrate divalent tin, etc. Other sources of ions of bivalent tin include halide divalent tin, for example, chlorides of divalent tin bromide divalent tin iodide divalent tin and chloride dihydride divalent tin. In one implementation, the ion source of divalent tin is a f is arid divalent tin, in another implementation of the chloride dehydrate or trihydrate divalent tin, or gluconate divalent tin. United salt of divalent tin may be present in amounts of from about 0,001% to about 11%, by weight of the compositions for oral care mouth. Salts of divalent tin can, in one implementation, be present in an amount from about 0.01% to about 7%, in another implementation from approximately 0.1% to approximately 5%, and in another implementation from about 1.5% to about 3%, by weight of the composition for oral care mouth.

Acceptable oral carrier

The media data components of the compositions can be any acceptable oral basis, acceptable for use in the oral cavity. The media may contain acceptable cosmetic and/or therapeutic active substances. Such active substances include any substance that, in General, is considered as safe for use in the oral cavity and which changes only the appearance and/or health of the oral cavity, including but not limited to the above, means to prevent the formation of dental stones, the sources of fluoride ions, the ion source of divalent tin, bleach, antibacterial, funds from the unpleasant smell, with whom estva from sensitivity funds from erosion, means of action of anti-caries, anti-plaque, anti-inflammatory agents, nutrients, antioxidants, antiviral agents, analgesics and anesthetics, H-2 antagonists and mixtures thereof. If the level of cosmetic and/or therapeutic active substances in the composition for the care of mouth is one implementation of from about 0,001% to about 90%, in another implementation from about 0.01% to about 50%, and in another implementation from about 0.1% to about 30%, by weight of the composition for oral care mouth.

The active substance

One of the advantages of amorphous silica is its compatibility with other substances, especially substances that are reactive and can lose effectiveness, for example active substances. Since amorphous silica does not react so with the active substances, as precipitated silica and other conventional abrasives, fewer active substances can be used with the same efficiency. If the active substance has any possible negative aesthetic properties, such as unpleasant or strong taste, astringent properties, staining or other negative aesthetic property, it may be preferred Myung is the neck of the amount of the active substance. Additionally, the use of a smaller quantity of the active substance for the same or similar efficiency is more economical. Alternatively, when using the same amount of the active substance, as used traditionally, the active substance will have a greater efficiency, because more of it is available to provide useful effect. Since amorphous silica little harder than conventional abrasives such as precipitated silica, amorphous silica can also remove more seeds and/or better clean.

Active substances include, but are not limited to the above, antibacterial active agents, anti-plaque action of anti-caries assets, sensitivity, funds from erosion, oxidants, anti-inflammatory agents, means to prevent the formation of dental stones, nutrients, antioxidants, analgesics, anesthetics, H-1 and H-2 antagonists, antiviral active substances and combinations thereof. Substance or ingredient can be categorized as more than one type of substance. For example, the antioxidant can also be a remedy against plaque and antibacterial active substance Examples of acceptable active agents include fluoride divalent tin, sodium fluoride, essential oils, mono is alkylphosphate, hydrogen peroxide, CDS, chlorhexidine, triclosan, and combinations thereof. The following is a non-limiting list of active substances which can be used in the present invention.

The fluoride ion

The present invention may contain a safe and effective amount of fluoride compounds. The fluoride ion may be present in a quantity sufficient to provide a concentration of fluoride ion in the composition at 25°C. and/or in the same implementation can be used at levels from about 0,0025% to about 5.0 percent by weight, in another implementation from about 0,005% to approximately 2.0% by weight, to ensure the action of anti-caries efficacy. A wide variety of substances, providing the fluoride ion may be used as sources of soluble fluoride in these compositions. Examples of acceptable substances, providing the fluoride ion, which is described in U.S. patent No. 3,535,421 and 3,678,154. Examples of sources of fluoride ions include:

fluoride divalent tin, sodium fluoride, potassium fluoride, floridain, sodium monitoroff, fluoride, zinc and many others. In one implementation, the composition means for care of the teeth contains fluoride divalent tin or sodium fluoride, and mixtures thereof.

The pH of the composition to care for the oral cavity, can range from approximately 3 to AP is sustained fashion 10. the pH is typically measured as the pH of the suspension by methods known in this field. Depending on the active substances used in the composition for the care of the oral cavity may be desirable different pH. For compositions containing fluoride, it may be desirable to have a pH value slightly lower than a typical means to care for teeth. Typical compositions for oral care mouth with precipitated silica and fluoride have a pH sufficiently high to ensure that the fluoride in the composition is not formed fertility not then reacted with hydroxyl groups on the precipitated silica. As the number of hydroxyl groups on amorphous quartz is smaller than the number of hydroxyl groups on the precipitated silica, it is not a problem, and the pH of the composition to care for the oral cavity with an amorphous silica may be lower.

The composition containing amorphous silica and fluoride can have a pH less than about 6.0 or less than, approximately 5.5. The pH may be less than approximately 5.2 or approximately 5,0, it May be desirable to have a pH value from about 3.5 to about 5, or from about 2.4 to about 4.8. The pH may be below 5.5 to allow better absorption of fluoride, because more fluoride. Low LVEF is possible pH may contribute to the conditioning of the tooth surface for making larger amounts of fluoride. For compositions containing peroxide and amorphous silica, the pH can be less than 5.5 or less than 4.5. Composition with a peroxide and amorphous silica may be from about 3.5 to about 4.0 to. For compositions containing amorphous quartz, divalent tin and fluoride, it may be desirable to have a pH value less than a 5.0. The pH value is less than 5,0 can allow the formation of a larger number of species of divalent tin SnF3.

Means of preventing the formation of dental stones

Composition means for care of teeth in accordance with the present invention may also contain a means for preventing the formation of dental stones, which in one implementation may be present from about 0.05% to about 50%, by weight of the composition for the care of the oral cavity, in another implementation ranges from approximately 0.05% to approximately 25%, and in another implementation ranges from approximately 0.1% to approximately 15%. Means of preventing the formation of dental stones, can be selected from the group consisting of polyphosphates (including pyrophosphates) and their salts; polyaminopropyl acid (AMPS) and its salts; of polyolefin sulfonates and their salts; polyvinylacetatove and their salts; polyolefin phosphates and their salts; diphosphonates and salts; phosphonobutane carboxylic key is lots and its salts; polyphosphonates and their salts; polyvinylacetatove and their salts; polyolefin phosphonates and their salts; polypeptides; and mixtures thereof; polycarboxylates and their salts; carboxy-substituted polymers; and mixtures thereof. In one implementation, in this application applied polymer polycarboxylate, including the ones described in U.S. patent 5032386. Examples of such polymers that are commercially available, is gentre from International Speciality Products (ISP). In one implementation, the salts are alkali metal salts or ammonium salts. Polyphosphates, in General, are used because they are fully or partially neutralized water soluble alkali metal salts, such as salts of potassium, sodium, ammonium, and mixtures thereof. Salts of inorganic polyphosphates include tripolyphosphate, alkali metal (e.g. sodium), metropolitical, decollato displacing metals (for example, disodium), monocellate timelocked metals (e.g., trisodium), acid potassium phosphate, acidic sodium phosphate and sodium hexametaphosphate alkali metal (e.g. sodium), and mixtures thereof. Polyphosphates larger than metropolitical usually occur as amorphous glassy materials. In one implementation polyphosphates produces FMC Corporation, and they are commercially known as Stavos (n≈6), Hexapod (n≈13), and Glass H (n≈21, sodium hexametaphosphate and mixtures thereof. Pyrophosphate salts useful in the present invention, including the Ute pyrophosphates of alkali metals, pyrophosphates di-, tri - and mono-potassium or sodium, pyrophosphate salt displacing metals, pyrophosphate salt tetrasulfonic metals and mixtures thereof. In one implementation pyrophosphate salt selected from the group consisting of trinacria pyrophosphate, disodium divodurum pyrophosphate (Na2H2P2O7), Dikili pyrophosphate, tetranitro pyrophosphate (Na4P2O7), terkaly pyrophosphate (K4P2O7) and mixtures thereof. The polyolefin of the sulfonates include those in which the olefin group contains 2 or more carbon atoms and their salts. The polyolefin phosphonates include those in which the olefin group contains 2 or more carbon atoms. Polyvinylacetate include polyvinyltoluene acid. Diphosphonates and salts include azacycloheptane-2,2-diphosphonic acids and their salts, ions azacycloheptane-2,2-diphosphonic acids and their salts, azacycloheptane-2,2-diphosphonic acid, azacycloheptane-2,2-diphosphonic acid, N-methyl-azacyclopenta-2,3-diphosphonic acid, EHDP (ethane-1-hydroxy-1,1-diphosphonic acid), ANR (azacycloheptane-2,2-diphosphonic acid), ethane-1-amino-1,1-diphosphonate, dichloromethane-diphosphonate etc. Phosphonocrotonate acid or its alkali metal salts include RTA (phosphonopropyl tricarboxylic acid), RUTA (phosphonobutane-1,2,4-tricarboxylic acid), each of the acids or salts of school is full of metals. The polyolefin phosphates include those in which the olefin group contains 2 or more carbon atoms. Polypeptides include poliasparaginovaya and polyglutamine acid.

Whitening tool

A bleaching agent may be included as active substance in these compositions funds for the care of teeth. The active substance acceptable to whitening, are selected from the group consisting of peroxides of alkali metals or alkaline earth metals, chlorides, metals, perborates, including mono and tetrahydrate, perphosphate, percarbonates, peroxyacids and persulfates, for example, persulfates of ammonium, potassium, sodium and lithium, and combinations thereof. Acceptable peroxide compounds include hydrogen peroxide, urea peroxide, calcium peroxide, carbamide peroxide, peroxide, magnesium peroxide, zinc peroxide of strontium and mixtures thereof. In one implementation of the peroxy compound is a carbamide peroxide. Acceptable metal chlorites include chlorite calcium, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite and potassium chlorite. Additional whitening active substances can be as hypochlorite and chlorine dioxide. In one implementation, the chlorite is a sodium chlorite. In another implementation of percarbonate is percarbonate sodium. In one implementation of the persulfate and are oxone. The level of these substances depends on the presence of oxygen or chlorine, respectively, of the molecule, which is capable of bleaching stains. In one implementation of the bleaching agents may be present at levels from about 0.01% to about 40%, in another implementation from approximately 0.1% to approximately 20%, in another implementation from about 0.5% to about 10%, and in another implementation from about 4% to about 7%, by weight of the composition for oral care mouth.

The oxidizing agent

Compositions of the present invention may contain an oxidizing agent, for example, the source of peroxides. Source peroxides may include hydrogen peroxide, calcium peroxide, carbamide peroxide, or a mixture thereof. In some implementations, the source of peroxide is hydrogen peroxide. Other peroxide active substances can include those that produce hydrogen peroxide when mixed with water, such as percarbonate, for example, percarbonate sodium. In certain implementations, the source of peroxides can be in the same phase as the ion source of divalent tin. In some implementations, the composition comprises from about 0.01% to about 20% source peroxides, in other implementations from about 0.1% to about 5%, in certain Khujand is staliniach from about 0.2% to about 3%, in another implementation from approximately 0.3% to approximately 2.0% source peroxides, by weight of the composition for the care of the oral cavity. Source peroxides can be provided as free ions, salts, complexes or encapsulated. Desirable is that the peroxide in the composition was stable. Peroxide may provide a means of reducing staining according to the measurements using analysis of cyclic coloring or other relevant methods.

In addition to the optional ingredients are described in detail below, certain thickeners and flavoring agents offer the best compatibility with oxidizing agents such as peroxide. For example, in some implementations, the preferred thickeners can be a cross-linked polyvinylpyrrolidone, polyacrylates, alkylated polyacrylates, alkylated cross-cross-linked polyacrylates, polymeric alkylated polyethers, carbomer, alkylated carbomer, gel mesh, nonionic polymeric thickeners, Sepinov EMT 10 (Seppic-hydroxyethylacrylate/sodium acrylamidoethyl copolymer). Pure Thix 1450, 1442, NN (PEG 180 Laureth-50/TMMR or polyester 1-Rockwood), Structure 2001 (Akzo-Acrylates/Steareth-20 itaconate copolymer), Structure 3001 (Akzo-Acrylates/Ceteth-20 itaconate copolymer), Aculyn 28 (Dow Chemical/Rohm and Haas-crylates/Beheneth-25 methacrylate copolymer), Genopur 350D (Clariant), Aculyn 33 (Dow Chemical/Rohm and Haas-Acrylates copolymer), Aculyn 22 (Dow Chemical/Rohm and Haas-Acrylates/Steareth-20 methacrylate copolymer), Aculyn 46 (Dow Chemical/Rohm and Haas-PEG-150/stearyl alcohol/SMDI copolymer), a (cross-linked carboxymethyl cellulose Hercules), Structure XL (hydroxypropyl starch phosphate - National Starch), and mixtures thereof.

Other acceptable thickeners may include a polymeric sulfonic acid, for example, Aristoflex AVC, AVS, BLV and NIV (Clariant, acryloyldimethyltaurate polymers, copolymers and crosslinked polymers), Diafbrmer (Clariant, aminoxide-methacrylate copolymer), Genapol (Clariant, polyglycidyl ether of fatty alcohols and alkilirovanny polyglycol ethoxylated fatty alcohols), fatty alcohols, ethoxylated fatty alcohols, high molecular weight non-ionic surfactants, such as BRIJ 721 (Croda), and mixtures thereof.

Acceptable system flavouring substances, in particular compatible with the peroxide, include those described in patent application U.S. 2007/0231278. In one implementation, the system flavouring substances it contains menthol in combination with at least one secondary cooling means, along with selected traditional flavouring components, which have been found, are relatively stable in the presence of peroxide. By "stable" in this application means that the character or profile flavouring substances does not change auth much or agreed during the shelf life of the product.

This composition may contain from about 0.04% to 1.5% of the total cooling means (menthol + secondary coolant) with at least about 0.015% menthol by weight. Typically, the level of menthol in the final composition is in the range from about 0.015 percent to about 1.0% and the secondary coolant (money) is in the range of from about 0.01% to about 0.5%. Preferably, the level of total cooling means is in the range from approximately 0.03% to approximately 0.6%.

Acceptable secondary cooling means or cooling means for use with menthol, include a wide variety of substances, such as carboxamide, ketals, diols, metrovia esters and mixtures thereof. Examples of secondary coolants in these compositions are paramenter carboxamide agents, for example N-ethyl-p-Menten-3-carboxamide, commercially known as "WS-3", N,2,3-trimethyl-2-isopropylmalonic, known as "WS-23", and other series, such as WS-5, WS-11, WS-14 WS-30. Additional acceptable cooling means include 3-1-methoxypropane-1,2-diol known as TK-10 manufactured Takasago; entepicondylar known as MGA; metrovia esters, for example, methylacetate, methylacetoacetate, Mantellate known as Frescolat®, comes with a C is th Haarmann and Reimer, and monomethylamine under the trade name Physcool from V.Mane. Terms menthol and Menthyl, as used in this application include the right - such as the isomers of such compounds and their racemic mixture. TC-10 is described in U.S. patent No. 4,459,425, Amano et al., issued July 10, 1984 WS-3 and other agents described in U.S. patent No. 4,136,163. Watson, et al., issued on January 23, 1979

Traditional aromatic components, which have been found, are relatively stable in the presence of peroxide, include methyl salicylate, utililities, methylcinnamic, ethylcinnamate, BUTYLCARBAMATE, ethyl butyrate, ethyl acetate, methylanthranilate, ISO-amylacetate, ISO-Adalbert, allylcapronate, eugenol, eucalyptol, thymol, cinnamic alcohol, cinnamic aldehyde, octanol, octanal, decanal, decanal, phenethyl alcohol, benzyl alcohol, benzaldehyde, alpha-terpineol, linalool, limonene, citral, vanillin, ethylvanillin, propergate, maltol, eternality, heliotropin, anethole, dihydrouracil, carvon, Oksanen, Menton, β-damascenone, ionon, gamma decalactone, gamma nonalactone, gamma undecalactone, 4-hydroxy-2,5-dimethyl-3(2H)-furanone and mixtures thereof. In General, acceptable flavoring agents are containing structural features and functional groups, less prone to oxidation by peroxide. They include derivatives of aromatic chemical washes is in, which are saturated or contain stable aromatic cycles or ester group. Also acceptable are aromatic chemical substances, which may undergo some oxidation or decay without significant changes to the nature or profile of the flavouring substances in the result. Flavouring substances in common use in the compositions at levels of from about 0,001% to about 5%, by weight of the composition.

In some implementations, the pH of the composition may range from approximately 3.5 to approximately 5.5, which may provide additional stability for the oxidizer. In some implementations, the composition may further comprise an ion source of divalent tin. In some implementations, the present invention can provide a method of reducing plaque, gingivitis, sensitivity, unpleasant smell from a mouth, erosion, cavities, Tartar and staining by introducing into the oral cavity of the subject composition containing amorphous silica and peroxide. In some implementations, the present invention provides a method of reducing plaque, gingivitis, sensitivity, unpleasant smell from a mouth, erosion, cavities, Tartar and staining by introducing into the oral cavity of the subject of the first composition not containing peroxy the, and then the composition containing amorphous silica and peroxide. In some implementations, the composition may be in the same phase. In some implementations, the composition may contain an oxidant and one or more sources of fluoride ions, the ion sources of zinc, a source of calcium ions, phosphate ion sources, ion sources of potassium, strontium ion sources, ion sources of aluminum, a source of magnesium ions, or combinations thereof. In some implementations, the composition may contain an oxidizer and chelant, which are selected from the group consisting of polyphosphates, polycarboxylates, polyvinylpyrrolidone, polyvinyl alcohol, polyester polymer, polymer alkylphosphate, copolymers metilfenidato ether and maleic anhydride, polyphosphates and mixtures thereof. In some implementations, the composition may contain an oxidizing agent and an active ingredient for the care of the oral cavity, which are selected from the group consisting of antibacterial agents, anti-plaque, anti-inflammatory agents, the action of anti-caries means, means for preventing the formation of dental stones, funds from erosion, funds from unpleasant odor, medium sensitivity, nutrients, analgesics, anesthetics, H-1 and H-2 antagonists, antiviral active substances and their combinations. Some made the s, the antibacterial agent may be selected from the group consisting of pyridinium chloride, chlorhexidine, hexetidine, triclosan, metal ions, essential oils, and mixtures thereof.

Antibacterial

Antibacterial agents can be included in compositions of funds for care of teeth in accordance with the present invention. Such agents may include, but are not limited to the above, cationic antibacterial agents such as chlorhexidine, alexidine, hexetidine, benzalconi chloride, domiphen bromide, pyridinium chloride (CPC), tetradecylbenzene chloride (TPC), N-tetradecyl-4-ethylpyridinium chloride (TDEPC), octenidine, bisbiguanide, agents on the basis of zinc ions or divalent tin, grapefruit extract, and mixtures thereof. Other antibacterial and antimicrobial agent include, but are not limited to the above: 5-chloro-2-(2,4-dichlorophenoxy)-phenol, commonly referred to as triclosan; 8-hydroxyquinoline and its salts, copper compounds II, including, but not limited to the above, the chloride copper (II)sulfate copper (II)acetate copper (II)fluoride, copper (II) hydroxide copper (II); phthalic acid and its salts, including, but not limited to the above described in U.S. patent No. 4,994,262, including magnesium monopotassium phthalate; sanguinarine; salicylanilide; iodine; sulfonamides; phenols; delmopinol, octenol and other piperidine the new derived; preparations of Niacin; nystatin; Apple extract; thyme oil; thymol; antibiotics such as Augmentin, amoxicillin, tetracycline, doxycycline, minocycline, metronidazole, neomycin, kanamycin, pyridinium chloride and clindamycin; and analogs and salts of the above; methyl salicylate; hydrogen peroxide; metal chlorites; pyrrolidone telkominternet; laurinetaurine monochlorohydrin; and a mixture of all the above. In another implementation, the composition contains a phenolic antimicrobial compounds and their mixtures. Antimicrobial components may be present from about 0,001% to about 20% by weight of the composition for the care of the oral cavity. In another implementation of the antimicrobial agent in amount from about 0.1% to about 5% by weight of the compositions for the care of the oral cavity in accordance with the present invention.

Other antimicrobial means can be, but not limited to the above, essential oils. Essential oils are aromatic volatile oils that can be synthetic or can be obtained from plants by distillation, squeezing, or extracting, and they usually tolerate the smell or flavor of the plant from which they are derived. Useful essential oils can provide antiseptic activity. Some of these essential oils also act is as flavouring substances. Useful essential oils include, but are not limited to the above, citrus, thymol, menthol, methyl salicylate (Wintergreen oil), eucalyptol, carvacrol, camphor, atenol, carvon, eugenol, isoeugenol, lemon, Simen, n-decroly alcohol, citronel and-alpiner, methyl acetate, citronellyl acetate, methyleugenol, cineole, linalool, amillenial, saffrole vanilla, butter curly mint, peppermint oil, a little lemon, orange oil, sage oil, rosemary oil, cinnamon oil, oil of pimento, lauric oil, cedar leaf, perianal, verbena, anise oil, Laurel ordinary, benzaldehyde, bergamot oil, bitter almond, Hiroshima, cinnamic aldehyde, little citronella, clove oil, coal soot, eucalyptus oil, guaiacol, derivatives of tropolone, for example, hinokitiol, lavender oil, mustard oil, phenol, fenilsalitsilat, pine oil, pine needle, sassafras oil, lavender oil broadleaf, styrax, thyme oil, tolwinski balm, terpentine oil, clove oil, and combinations thereof. In one implementation of the essential oils are selected from thymol, methyl salicylate, eucalyptol, menthol and combinations thereof.

In one implementation in accordance with the present invention, provided compositions for the care of the oral cavity, containing a mixture of sun is ecaudata in the nature of aromatic ingredients or essential oils (EM), containing such aromatic ingredients, where the mixture shows excellent antimicrobial activity and contains at least two components where the first component is selected from acyclic or cyclic structures such as citral, neral, geranial, geraniol and nerol, and the second component is chosen from the containing loop or cyclic structures, such as eucalyptol, eugenol and carvacrol. Essential oils can be used to provide the above aromatic ingredients, including oils of lemongrass, citrus (orange, lemon, lime), citronella, geranium, rose, eucalyptus, oregano, noble Laurel and cloves. However, it may be preferable that the aromatic ingredients were provided as separate or purified chemicals, and is not supplied to the composition by adding natural oils or extracts, as these sources may include other components that may be unstable with other components of the composition or may be administered aromatic notes that are incompatible with the desired aromatic profile that leads to a less acceptable product from the point of view of organoleptics. Highly preferred for use in this application are natural oils or extracts that have been purified or concentrated to provide the I main the desired component(s).

Preferably, the mixture contains 3, 4, 5 or more of the above components. Large synergies from the point of view antimicrobial effectiveness can be obtained by mixing together a larger number of different components until the mixture contains at least one cyclic structure and a cyclic structure. A preferred mixture contains at least two cyclic structures, or at least two acyclic structure. For example, a mixture containing two acyclic structure (neral and geranial of citral and eugenol as a cyclic structure, it is highly preferred due to its effectiveness against bacteria of the oral cavity. Another preferred mixture contains three acyclic structure (geraniol, neral and geranial) and two cyclic structures (eugenol and eucalyptol). Examples of such mixtures is discussed in more detail in published application U.S. 2008/0253976 A1.

Other antibacterial agents can represent basic amino acids and salts. Other implementation may contain arginine.

The remedy for plaque

Composition means for care of teeth in accordance with the present invention may contain an anti-plaque, such as salts of divalent tin, copper salt, strontium salt, magnesium salt, copolymers carboxylating polymer is, such as Gantry or Dimethicone copolyol. Dimethicone copolyol selected from C12-C20 alkyldimethyl of Aprilov and mixtures thereof. In one implementation Dimethicone copolyol is acidisation copolyol, which is sold under the trade name Abil EM90. Dimethicone copolyol in one implementation can be present at levels from about 0,001% to about 25%, in another implementation from about 0.01% to about 5%, and in another implementation from about 0.1% to about 1.5% by weight of the composition for oral care mouth.

Anti-inflammatory agent

Anti-inflammatory agents may also be present in the compositions of funds for care of teeth in accordance with the present invention. Such agents may include, but are not limited to the above, non-steroidal anti-inflammatory (NSAID) agents oxicam, salicylates, propionic acid, acetic acid and fenamate. Such NSAIDs include, but are not limited to the above, Ketorolac, flurbiprofen, ibuprofen, naproxen, indomethacin, diclofenac, etodolac, indomethacin, sulindac, tolmetin, Ketoprofen, fenoprofen, piroxicam, nabumetone, aspirin, diflunisal, meclofenamic, methenamine acid, oxyphenbutazone, phenylbutazone and acetaminophen. The use of NSAIDs, such as Ketorolac, stated in U.S. patent 5,626,838. Described ways the s prevention and/or treatment of primary and recurrent squamous cell carcinoma of the oral cavity or oropharynx by local injection into the oral cavity or oropharynx effective amount of NSAID. Acceptable steroid anti-inflammatory agents include corticosteroids, for example fluocinolon and hydrocortisone.

Nutrients

Nutrients can improve the condition of the oral cavity and can be included in compositions of funds for care of teeth in accordance with the present invention. Nutrients include minerals, vitamins, oral nutritional supplements, gastric food additives and their mixtures. Minerals include calcium, phosphorus, zinc, manganese, potassium and mixtures thereof. Vitamins can be included with minerals or be used independently. Acceptable vitamins include vitamins C and D, thiamine, Riboflavin, calcium Pantothenate, Niacin, folic acid, nicotinamide, pyridoxine, cyanocobalamin, para-aminobenzoic acid, bioflavonoids, and mixtures thereof. Oral nutritional supplements include amino acids, lipotropic, fish oil, and mixtures thereof. Amino acids include, but are not limited to the above, L-tryptophan, L-lysine, methionine, threonine, l-carnitine or L-carnitine and mixtures thereof. Lipotropic include, but are not limited to the above, choline, Inositol, betaine, linoleic acid, linolenic acid and mixtures thereof. Fish oil contains large amounts of omega-3 (N-3) polyunsaturated fatty acids, eykozapentaenovuyu and docosahexaenoic acid. Gastric nutritional supplements including the Ute, but not limited to the above, protein products, glucose polymers, corn oil, sunflower oil, medium chain triglycerides. Minerals, vitamins, oral nutritional supplements and gastro food additives are described in more detail in Drug Facts and Comparisons (liner service information on medicines) Wolters Kluer Company, St. Louis, Mo., (c)1997, pps. 3-17 and 54-57.

Antioxidants

Antioxidants, in General, recognized as useful in the compositions of funds for the care of teeth. Antioxidants are described in such texts as Cadenas and Packer, the Handbook of Antioxidants, (c) from 1996 Marcel Dekker, Inc. Antioxidants useful in the present invention include, but are not limited to the above, vitamin E, ascorbic acid, uric acid, carotenoids, vitamin a, flavonoids and polyphenols, herbal antioxidants, melatonin, aminoindoles, lipaemia acid and mixtures thereof.

Analgesics and anesthetics

Analgesic or antisense agents can also be present in the compositions of funds for care of teeth in accordance with the present invention. Analgesics are agents that relieve pain by Central action that increases the pain threshold without disturbing consciousness, or changing other sensory modalities. Such agents may include, but are not limited to the above: strontium chloride; potassium nitrate, sodium fluoride, nitrate in the model; the acetanilide; phenacetin; azertia; tiorfan; spiradoline; aspirin, codeine; thebaine; Levorphanol; hydromorphone; Oxymorphone; phenazocine, fentanyl, buprenorphine; butanol; nalbufin; pentazocine; natural herbs, such as tanning nut; Asarum; cubbin; galangal; skullcap; Liangmianzhen and Baizhi. Anesthetics, or local analgesics, such as acetaminophen, sodium salicylate, trolamine salicylate, lidocaine and benzocaine, may also be present. Such analgesic active substance are described in detail in Kirk-Othmer, Encyclopedia of Chemical Technology, Fourth Edition, Volume 2, Wiley-Interscience Publishers (1992), p.729-737.

H-1 and H-2 antagonists and antiviral active substances

The present invention can also optionally contain selective H-1 and H-2 antagonists, including compounds described in U.S. patent 5,294,433. Antiviral active substances, useful in the composition include any known active substances, which are usually used to treat viral infections. Such antiviral active substances described in Drug Facts and Comparisons, Wolters Kluer Company, (c)1997, p.402(a)-407(z). Specific examples include antiviral active substances described in U.S. patent 5,747,070, issued may 5, 1998 In the specified patent describes the use of salts of divalent tin to control viruses. Salts of divalent tin and other antiviral active substances detail about isany in Kirk & Othmer, Encyclopedia of Chemical Technology, Third Edition, Volume 23, Wiley-lnterscience Publishers (1982), p.42-71. Salts of divalent tin, which can be used in the present invention include organic carboxylates of divalent tin and inorganic halide divalent tin. While it can be used fluoride divalent tin, it is typically used only in combination with other halide of the divalent tin or one or more carboxylates of divalent tin or other therapeutic agent.

Halirous agents

These compositions can optionally contain chelating agents, also called Galanti or airing, many of them also have activity against the formation of plaque or activity in relation to teeth. The use of chelating agents in products for oral care mouth is useful due to their ability to bind calcium, for example, in the cell walls of bacteria. Chelating agents can also destroy plaque by removing calcium from the calcium bridges, which helps keep this intact biomass. Chelating agents are also capable of binding to the complexes of metal ions and thus to contribute to the prevention of their adverse effects on the stability or appearance of the products. The chelation of ions, such as iron sludge is copper, slows the deterioration due to oxidation of the finished products.

Additionally, galanty can in principle remove stains by binding to the surfaces of the teeth, thus shifting the color of the body or chromagen. The retention of such organic acids can also prevent the accumulation of spots, destroying the binding sites of the color bodies on the surfaces of teeth.

Therefore, galanty can assist in helping to reduce spots and improve cleaning. Chelant may improve treatment, whereas the amorphous silica and the abrasive is cleaned by a mechanical mechanism, while chelant can help to provide chemical cleaning. Since amorphous quartz is good mechanical cleaner, it can remove more stains, so chelant may be desired to hold, suspension or complexing with the spot, and, therefore, unable again to blur the tooth surface. Additionally, chelant can cover the surface of the tooth to prevent new stains.

Galanti can be preferably added to the composition containing cationic antibacterial agents. It may be desirable to add Galanti in compositions containing bivalent tin. Chelant can contribute to the stabilization of divalent tin and store a greater amount of divalent tin is available. Chelant can be used in the compositions of divalent tin, which have a pH value higher than approximately 4,0. In some compositions, the divalent tin can be stable without the need for Galante because of divalent tin is more stable with an amorphous silica compared to precipitated silica.

Acceptable chelating agents include soluble phosphate compounds such as phytates and linear polyphosphates containing two or more phosphate groups, including tripolyphosphate, metropolitical and hexametaphosphate, among other things. The preferred polyphosphates are those that have the number of phosphate groups, n is on average from about 6 to about 21, such as polyphosphates, commercially known as Stavos (n≈6), Hexapod (n≈13), and Glass H (n≈21). Other polyesterurethane compounds may be used in addition to or instead of polyphosphate, in particular polyesterurethane Inositol compounds such as phytic acid, myo-Inositol, pentakis(distortional); myo-Inositol tetrakis(distortional), myo-Inositol, trikes(distortional), and their alkali metal salts, alkaline earth metal or ammonium. Preferred in this application is phytic acid, also known as myo-Inositol 1,2,3,4,5,6-hexacis(divodurum ofat) or Inositol hexaphosphoric acid, and their alkali metal salts, alkaline earth metal or ammonium. In this application, the term "phytate" includes phytic acid and its salts, and other polyesterurethane Inositol connection. The amount of chelating agent in the compositions will depend on the used chelating agent and typically will be from at least about 0.1% to about 20%, preferably from about 0.5% to about 10%, and more preferably from about 1.0% to about 7%.

In addition, other phosphate compounds useful in this application because of their ability to bind to solubilisate and transport calcium, are surface-active organophosphate compounds described above are useful as agents useful for the teeth, including organic phosphate mono-, di - or truefire.

Other acceptable agents chelating properties for use in the control of plaque, Tartar and stains include polyphosphonate described in U.S. patent No. 3,678,154 issued by Widder et al., U.S. patent No. 5,338,537 issued White, Jr., and U.S. patent No. 5,451, issued Zerby et al; carbamylphosphate in U.S. patent No. 3,737,533 issued Francis; allowability polymer or copolymer in U.S. patent No. 4,847,070, July 11, 1989, issued by Pyrz et al., and in U.S. patent No. 4,661,341, April 28, 1987,issued by Benedict et al.; sodium alginate in U.S. patent No. 4,775,525, issued October 4, 1988, Pera; polyvinylpyrrolidone in GB 741,315, WO 99/12517 and U.S. patent No. 5,538,714 issued by Pink et al., and copolymers of vinylpyrrolidone with carboxylates in U.S. patent No. 5,670,138 issued by Venema et al. and in the publication of JP No. 2000-0633250 issued by Lion Corporation.

In addition, other chelating agents suitable for use in the present invention are anionic polymer polycarboxylate. Such substances are well known in the prior art, used in the form of free acids or partially or preferably fully neutralized water soluble alkali metal salts (e.g. potassium and preferably sodium) or ammonium salts. Examples are 1:4-4:1 copolymers of maleic anhydride or acid with another of the polymerized ethylene-unsaturated monomer, preferably methylviologen ether (methoxyethanol)having a molecular weight (M.W.) of about 30,000 to about 1000000. Such copolymers are available, for example, as Gentra® AN 139 (M.W. of 500,000), AN 119 (M.W. 250,000 in) and S-97 pharmaceutical purity (M.W. 70000), from GAF Chemicals Corporation.

Other workers polymer polycarboxylate include 1:1 copolymers of maleic anhydride with acrylate, hydroxyethylmethacrylate, N-vinyl-2-pyrrolidone or ethylene, the latter available such as Monsanto EMA No. 1103, M.W. 10,000 and EMA Grade 61, and 1:1 with aimery of acrylic acid with methyl or hydroxyethylmethacrylate, methyl or acrylate, isobutylparaben ether or N-vinyl-2-pyrrolidone.

Additional job polymer polycarboxylate described in U.S. patent 4,138,477, February 6, 1979, issued by Gaffar, and U.S. patent 4,183914,15 January 1980, issued by Gaffar et al., and include copolymers of maleic anhydride with styrene, isobutylene or ethylvanillin ether; poly (acrylic, polietilenovoy and primulinum acid; and sulfoacetate oligomers with M.W. 1000, available as Uniroyal ND-2.

Other acceptable Galanti include polycarboxylic acids and their salts, described in U.S. patent No. 5,015,467 issued by Smitherman and 5,849,271 and 5,622,689, both issued Lukacovic; such as tartaric acid, citric acid, gluconic acid, malic acid, succinic acid, diantara acids and their salts, such as gluconate and sodium citrate or potassium, the combination of citric acid/ citrate of an alkali metal; disodium tartrate; dicale tartrate; sodium tartrate potassium; acid sodium tartrate; acid potassium tartrate; acid or salt form, sodium tartrate monoacrylate, potassium tartrate disuccinate and their mixtures. In some implementations can be a mixture or combination of chelating agents.

Means, having an affinity for teeth

The present invention may include a vehicle having an affinity for teeth. For the purposes of this application, means having affinity to the teeth, on the obtained also as organic acids. Acceptable agents can be a polymeric surface-active agents (PMSA's), including polyelectrolytes, more specifically, anionic polymers. PMSA's contain anionic groups, for example, phosphate, phosphonate, carboxy, or mixtures thereof, and thus, can interact with cationic or positively charged groups. Description "mineral" is intended to describe the surface activity or affinity of the polymer to mineral surfaces, such as the minerals calcium phosphate in teeth.

PMSA''s useful in these compositions, because of their many beneficial effects, such as preventing the formation of spots. Believe that PMSA's provide useful effect of preventing the formation of stains due to their reactivity or affinity to the mineral or the surfaces of the teeth, leading to desorption of particles of unwanted proteins adsorbed plaque, in particular, associated with linking color bodies, staining of teeth, development of Tartar and attracting unwanted microbial species. Holding such PMSA''s teeth may also prevent the buildup of stains due to the destruction of the binding sites of the color bodies on the surfaces of teeth.

The ability PMSA's to bind the ingredients to care for your mouth, contributing to the formation of spots, such as ions of divalent tin and katianna is an antibacterial agent, also find it useful. PMSA will also provide the effects of conditioning the surface of the tooth, which results in obtaining the desired impact on the surface thermodynamic properties and properties of surface films, which affects superior aesthetic properties and the feeling of cleanliness during and, most importantly, after rinsing or brushing. Many of these agents, as well as expected benefits of control Tartar when included in a composition for caring for the oral cavity, thus providing improved as the appearance of the teeth and their tactile sensations to the user.

PMSA's include any agent which will have a strong affinity to the surface of the teeth, atlacatl polymer layer or coating on the surface of the teeth and to produce desired effects of the surface modification. Acceptable examples of such polymers are polyelectrolytes, for example, condensed phosphorylated polymers; polyphosphonates; copolymers of phosphate - or phosphonate-containing monomers or polymers with other monomers such as ethylene-unsaturated monomers and amino acids with other polymers, for example, proteins, polypeptides, polysaccharides, poly(acrylate), poly(acrylamide), poly(methacrylate), poly(ethacrylate), poly(hydroxyethylmethacrylate), poly(vinyl alcohol), poly(small is andnew anhydride), poly(maleate) poly(amide), poly(ethylenimine), poly(ethylene glycol), poly(propylene glycol), poly(vinyl acetate) and poly(vinylbenzyl chloride); polycarboxylate and carboxy-substituted polymers; and mixtures thereof. Acceptable polymeric mineral surface active agents include carboxy-substituted alcohol polymers described in U.S. patent No. 5,292,501; 5,213,789, 5,093,170; 5,009,882; and 4,939,284; all issued Degenhardt et al. and polymers on the basis of diphosphonates described in U.S. patent 5,011,913 issued by Benedict et al; synthetic anionic polymers, including polyacrylates and copolymers of maleic anhydride or acid and metilidinovy ether (for example, Gentra®), as described, for example, in U.S. patent 4,627,977 issued by Gaffar et al. The preferred polymer is modified by diphosphonates polyacrylic acid. The polymers having the activity must have a tendency to surface binding for desorption of proteins plaque and to stay bound to the surfaces of the enamel. For surfaces of teeth polymers with terminal or side chain of a phosphate or phosphonate functional groups are preferred, although other polymers with the activity of binding minerals can be effective depending on epinasty adsorption.

Additional examples of acceptable phosphonate-containing polymeric mineral surface is IDT-active agents include genialny diphosphonate polymers, described as a means to prevent the formation of dental stones, in U.S. patent 4,877,603 issued by Degenhardt et al; copolymers containing phosphonate groups, described in U.S. patent 4,749,758. issued Dursch et al. and in GB 1,290,724 (both issued by Hoechst), acceptable for use in detergents and cleaning compositions; and copolymers and ketelaere described as useful for applications, including inhibition of delamination and corrosion, coatings, cements, and ion-exchange resins in U.S. patent 5,980,776 issued by Zakikhani et al., and the U.S. patent 6,071,434, issued to Davis et al. Additional polymers include water-soluble copolymers vinylphosphonic acid and acrylic acid and their salts, described in GB 1,290,724 where the copolymers contain from about 10% to about 90% by weight vinylphosphonic acid and from about 90% to about 10% by weight of acrylic acid, especially where the copolymers have a mass ratio vinylphosphonic acid and acrylic acid 70% vinylphosphonic acid and 30% acrylic acid; 50% vinylphosphonic acid and 50% acrylic acid; or 30% vinylphosphonic acid and 70% acrylic acid. Other useful polymers include water-soluble polymers described Zakikhani and Davis, obtained by copolymerization diphosphonate or polyphosphonate monomers having one or more unsaturated C=C bonds (e.g., vinylidene-1,1-Defo the background acid and 2-(hydroxyphenyl)ethylidene-1,1-diphosphonic acid), with at least one additional compound having unsaturated C=C bond (for example, acrylate and methacrylate monomers). Acceptable polymers include diphosphonate/acrylate polymers, supplied by Rhodia under the name of ITC 1087 (average MW 3000-60000) and Polymer 1154 (average MW 6000-55000).

Preferred PMSA will be stable with other components of the composition for the care of the oral cavity, such as fluoride ions and ions of metals. Also preferred are polymers which have limited hydrolysis in compositions with a high content of water, thus allowing the development of a simple, single phase means for care of the teeth or mouthrinse. If PMSA does not have these properties, stability, one option is a two-phase composition with a polymeric mineral surface active substance, separated from the fluoride or other incompatible component. Another option is to develop a non-aqueous, essentially non-aqueous or partially aqueous compositions to minimize reaction between the PMSA and other components.

Another preferred PMSA is polyphosphate. Under polyphosphate, in General, understood as consisting of two more phosphate molecules, which are located mainly in the linear configuration, although there may be some cyclic derivatives. Although pyrophosphates (n=2)are technically the polyphosphates, desired polyphosphates are surrounded by three or more phosphate groups so that surface adsorption at effective concentrations provided sufficient unbound phosphate function, which increases the anionic surface charge and hydrophilic nature of the surfaces. The desired inorganic polyphosphate salts include sodium tripolyphosphate, metropolitical and hexametaphosphate, among other things. Polyphosphates greater than metropolitical usually occur as amorphous glassy materials. Preferred in these compositions are linear polyphosphates having the formula:

HO(HRO3)nX,

where X represents sodium, potassium or ammonium, and n is on average from about 3 to about 125. The preferred polyphosphates are polyphosphates having n on average from about 6 to about 21, such as commercially known as Stavos (n≈6), Hexapod (n≈13), and Glass H (n≈21), produced by FMC Corporation and Astaris. These polyphosphates may be used individually or in combination. Polyphosphates are sensitive to hydrolysis in compositions with a high content of water at acid pH, in particular less than pH 5. Thus, it is preferable to use long-chain polyphosphates, in particular Glass H with an average chain length is roughly 21. Believe that such long-chain polyphosphates, if they undergo hydrolysis, to form short-chain polyphosphates, which remain effective against dental plaque and provide useful effect, which consists in preventing the appearance of spots.

Also useful as tools, having affinity to the teeth, are polimernye phosphate compounds, in particular, polyesterurethane Inositol compounds such as phytic acid, myo-Inositol, pentakis(distortional); myo-Inositol tetrakis(distortional), myo-Inositol, trikes(distortional) and their alkali metal salts, alkaline earth metal or ammonium salts. Preferred in this application is phytic acid, also known as myo-Inositol 1,2,3,4,5,6-hexacis(distortional) or Inositol hexaphosphoric acid, and their alkali metal salts, alkaline earth metal or ammonium salts. In this application, the term "phytate" includes phytic acid and its salts, and other polyesterurethane Inositol connection.

Other surface-active phosphate compounds useful as funds, having affinity to the teeth, include organophosphates, such as phosphate mono-, di - or Trifonov, such as described in belonging to one holder application published as US 20080247973 A1. Examples of clucalc mono - di - and tri - alkyl and alkyl(poly)alkoxy phosphates, such as dodecyl phosphate, lauryl phosphate; Laureth-1 phosphate; Laureth-3 phosphate; Laureth-9 phosphate; delaure-10 phosphate; trilaureth-4 phosphate; C12-18 PEG-9 phosphate and their salts. Many of them are commercially available from suppliers, including Croda; Rhodia; Nikkol Chemical; Sunjin; Alzo; Huntsman Chemical; Clariant and Cognis. Some preferred agents are polymers, for example, contain repeated alkoxygroup as a polymer part, in particular 3 or more ethoxy, propoxy, isopropoxy or butoxy group.

Additional acceptable polymer organophosphate agents include dextran phosphate, polyglycoside phosphate, alkylpolyglycoside phosphate, polyglycerol phosphate, alkylpolyglycoside phosphate, polyether phosphates and alkoxysilane polyol as one phosphate. Some specific examples are PEG-phosphate, PPG phosphate, PPG alkyl phosphate, PEG/PPG phosphate, the alkyl PEG/PPG phosphate, PEG/PPC/PEG-phosphate, dipropyleneglycol phosphate, PEG glyceryl phosphate, PBG (polybutylene glycol) phosphate, PEG-cyclodextrin phosphate, PEG, sorbitan phosphate, PEG alkalarian phosphate and PEG methylglucoside phosphate.

Additional acceptable polimernye phosphates include alkylphenolate phosphate, alkalarian phosphate, alkylmethacrylamide phosphate, alkylsulfate phosphates.

Other useful tools that have affinity to the teeth, include siloxane polymers, functionalityand GRU is the groups of carboxylic acids, for example, as described in U.S. patent No. 7,025,950 and 7,166,235, both issued by Procter & Gamble Co. Such polymers include hydrophobic siloxane skeleton and hung anionic fragments containing carboxypropyl and able to Deposit on the surfaces of the compositions are water-based or essentially non-aqueous compositions, forming essentially a hydrophobic coating on the treated surface. Carboxy-functionalityand siloxane polymers, it is believed, join polar surfaces and form a coating on them by the electrostatic interaction, i.e. kompleksoobrazovanija between suspended carboxyglutamic and calcium ions present in the teeth. Carboxypropyl, thus, serve as anchors for the siloxane polymer skeleton on the surface, thus modifying it to hydrophobicity, which then gives many useful effects for the target use of the surface, for example, ease of cleaning, stain removal and prevention of their formation, whitening, etc. Carboxy functionalityand siloxane polymers also apply to improve the deposition of active substances on the surface and to improve the retention and effectiveness of these active substances on the surface.

Also useful as tools, having affinity to the teeth, odor stormie or dispersible in water, polymeric agents, which is obtained by copolymerization of one or a mixture of vinylpyrrolidone (VP) monomers with one or a mixture of alkenyl carboxylate (AU) monomers, specifically C2-C12alkenyl esters of saturated unbranched or branched C1-C19alkylcarboxylic acids described in belonging to the same patent U.S. patent No. 6,682,722. Examples include copolymers of vinylpyrrolidone with one or a mixture of vinyl acetate, WikiProject, or vinylboronate. Preferred polymers have an average molecular weight in the range from about 1000 to about 1000000, preferably from 10,000 to 200,000, even more preferably from 30,000 to 100,000.

The number of funds that have affinity to the teeth, will typically be from about 0.1% to about 35% by weight of the entire composition for the care of the oral cavity. In the compositions of money to care for teeth, the amount is preferably from about 2% to about 30%, more preferably from about 5% to about 25%, and most preferably from about 6% to about 20%. In the compositions of the mouth rinser, the number of funds that have affinity to the teeth, is preferably from approximately 0.1% to 5% and more preferably from about 0.5% to about 3%.

Updat the additional active substance

Additional active substances acceptable for use in the present invention, may include, but are not limited to the above, insulin, steroids, medicines based on herbs and other plants. Additionally, can also be included anti-gingivitis or to care for the gums, known from the prior art. Components, giving the feeling of clean teeth, can be optionally included. Such components may include, for example, baking soda or Glass-H. Also, it is recognized that in certain forms of therapy, the combination of the above tools can be useful for optimal effect. Thus, for example, antimicrobial and anti-inflammatory agent can be combined in one composition means for care of the teeth to provide a combination of efficiency.

Optional tools for use include such well-known substances as synthetic anionic polymers, including polyacrylates and copolymers of maleic anhydride or acid and metilidinovy ether (for example, Gentra), as described, for example, in U.S. patent 4,627,977, as well as, for example, polyaminopropyl acid (AMPS), zinc citrate trihydrate, polyphosphates (e.g., tripolyphosphate; hexametaphosphate), diphosphonates (e.g., EHDP; ANR), polypeptides (e.g., polyaspartates the Yu and polyglutamic acid) and mixtures thereof. Additionally, the composition means for care of the teeth may include a polymeric carrier, for example, described in U.S. patent No. 6,682,722 and 6,589,512 and in patent applications U.S. No. 10/424,640 and 10/430,617.

Other optional ingredients

Buferiruemoi tools

Composition means for care of teeth can contain bufonidae tool. Buferiruemoi means, as used in this application refers to the funds that can be used to adjust the pH of the compositions of funds for care of teeth in the range of from about pH 3.0 to about pH 10. Buferiruemoi tools include hydroxides of alkali metals, ammonium hydroxide, organic ammonium compounds, carbonates, sexierbovine, borates, silicates, phosphates, imidazole and mixtures thereof. Specific buferiruemoi tools include monolatry phosphate, trinacria phosphate, sodium benzoate, benzoic acid, sodium hydroxide, potassium hydroxide, carbonate salts of alkali metals, sodium carbonate, imidazole, pyrophosphate salt, sodium gluconate, lactic acid, sodium lactate, citric acid and sodium citrate. Buferiruemoi tools are used at the level of from about 0.1% to about 30%, preferably from about 0.1% to about 10%, and more preferably from about 0.3% to about 3%, by weight of the compositions means is to care for the teeth.

Dyes

Dyes can also be added in this composition. The dye may be in the form of an aqueous solution, preferably 1% dye in aqueous solution. Can also be used pigments, peels, powder fillers, talc, mica, magnesium carbonate, calcium carbonate, bismuth oxychloride, zinc oxide and other substances that can create visual changes in compositions of funds for the care of teeth. Solutions of dyes and other agents, in General, contain from about 0.01% to about 5%, by weight of the composition. Titanium dioxide may also be added in this composition. Titanium dioxide is a white powder, which gives a matte finish compositions. Titanium dioxide, in General, contains from about 0.25% to about 5%, by weight of the composition.

Flavouring substance

Acceptable flavoring components include Wintergreen oil, oil of flowers, clove, menthol, anethole, methyl salicylate, eucalyptol, Cassia, 1-methylacetate, sage, eugenol, oil of parsley, Oksanen, alpha ireson, marjoram, lemon, orange, propergate, cinnamon, vanillin, ethylvanillin, heliotropin, 4-CIS-heptenal, diacetyl, methyl-para-tert-butylphenoxyacetyl, cranberries, chocolate, green tea, and mixtures thereof. Essential oils can also be included as a flavouring in the substances as described above in the discussion of antibacterial agents. The cooling means may also be included in the fragrance composition. Cooling means acceptable to the compositions include paramenter carboxyamide agents, such as N-ethyl-p-Menten-3-carboxamide (known commercially as " WS-3, WS-23, WS-5), MGA, TK-10, Physcool and mixtures thereof. Facilities that promote salivation, means for heating, means for numbness and other optional ingredients may be applied for delivery of a signal using the composition for oral care mouth. Due to the interaction with the deposited silica, fragrance components can be trapped or emulgirovanija, which leads to the effect of their disappearance, therefore, not to be felt by the user. On the contrary, the lack of interaction with amorphous silica can affect the amount of aromatic component that must be added to obtain a noticeable effect. In some implementations, the number present flavouring substances by weight of the composition may be about 10%, about 20%, or approximately 50% less than comparable compositions of precipitated silica, while achieving the same kind of influence on the aroma.

Composition for flavouring substances, which, in General, used to the positions to care for the oral cavity, present at levels from about 0,001% to about 5%, by weight of the composition for the care of the oral cavity. Composition for flavouring substances will preferably be present in an amount from about 0.01% to about 4%, more preferably from about 0.1% to about 3%, and more preferably from about 0.5% to about 2% by weight.

Similarly, the cooling means may not be adsorbed so in these compositions, which means that the cooling means can be more long-term or can be used in smaller quantities. Essential oils can also be absorbed to a lesser extent and can be used to achieve the same efficiency. Amorphous silica may not relate to gustatory receptor, as it makes precipitated silica, which means that the taste receptor may be more accessible for flavouring substances.

Other aesthetic benefits may be obvious to the users, for example, cleaning of the mouth and an increased sense of sweets or cold, for example. Improved smoothness, clean sensation in the oral cavity may lead to less feeling of dry mouth, also improved cleaning amorphous silica can help remove layers of mucin and improve the feel of onlinenot is. Other custom aesthetic advantage can be improved by rinsing the mouth compositions for the care of the oral cavity, because of the inert particles of amorphous silica, which does not stick together, but remain dispergirovannykh while the user is brushing his teeth brushed. Another possible advantage is improved foaming. Again, because of the amorphous silica is less reactive than precipitated silica, surfactants are more affordable and can happen superior foaming.

Some implementation may contain TRPV1 activator, activator transient receptor potential vanilloideae receptor 1, which is controlled by the ligand, non-selective cation channel, preferably expressively on the touch neurons of small diameter, and detects toxic and other substances. By adding a TRPV1 activator in the composition for the care of the oral cavity with the component, remove the taste of the user of the composition can feel superior taste of the entire composition for the care of the oral cavity without TRPV1 activator. Thus, TRPV1 activator acts in order to remove the unpleasant taste associated with many components that are used in the compositions for oral care mouth. Such activators mo is ut not only to remove the unpleasant taste, but can also reduce the feeling of dryness, by limiting the ability of the mouth to feel dry. In one implementation, TRPV1 activator contains anilinomethylene ether, zingerone, capsaicin, capsiate, Seagal, gingerol, piperine or a combination of both. In one implementation, TRPV1 activator is added in an amount of from about 0,0001% to approximately 0.25% by weight of the composition for oral care mouth.

Sweetener

Sweeteners can be added to the composition. These include sweeteners such as saccharin, dextrose, sucrose, lactose, xylitol, maltose, levulose, aspartame, sodium cyclamate, D-tryptophan, dihydrochalcones, Acesulfame, Sucralose, NOTAM and mixtures thereof. Various dyes may also be included in the present invention. Sweeteners, in General, used in compositions for oral care mouth at levels from about 0,005% to about 5%, by weight of the composition.

Thickeners

Can be used for more thickeners, such as polymeric thickeners. Acceptable thickeners are carboxyquinolone, carrageenan, hydroxyethyl cellulose, laponite and water-soluble salts of cellulose ethers such as sodium carboxymethylcellulose and sodium karboksimetiltselljuloza. Natural gums such as gum karaya, xanthan gum, gum Arabic is rabic and tragacanth gum, can also be used. Colloidal magnesium aluminum silicate or finely-divided silica can be used as part of the thickening agent to further improve the structure. Other thickeners may include alkylated polyacrylates, alkylated cross-cross-linked polyacrylates, or gel mesh. Thickeners can include polymeric polyether compounds such as polyethylene or polypropyleneoxide (M.W. 300-1000000), closed at the ends alkyl or acyl groups containing from 1 to about 18 carbon atoms.

Acceptable class of thickeners or gelling agents includes the class of homopolymers of acrylic acid, cross-linked with alkilany air pentaerythritol or alkilany ether sucrose, or carbomer. Carbomer commercially available from the B.F.Goodrich as a series of Carbopol®. In particular carbopol, including Carbopol 934, 940, 941, 956, and mixtures thereof.

Copolymers lactide and glycolide monomers, the copolymer having a molecular weight in the range from approximately 1,000 to approximately 120,000 units (average value), are useful for delivery of active agents in periodontal pockets or around the periodontal pockets as podlesney gel media." These polymers are described in U.S. patent No. 5,198,220; 5,242,910 and 4,443,430.

Through the interaction of precipitated silica with others who componentui composition, precipitated silica can affect the rheology of the composition over time. Amorphous quartz, however, due to the lack of interaction with other components of the composition, has a small effect on the rheology. This means that the composition for the care of the mouth with an amorphous silica are more stable over time, which, among other things, may allow better cleaning and better predictability. Thus, in some implementations, thickeners, combination and quantity may differ from traditional means to care for teeth. In the present invention, the thickening agent may be used in amounts from about 0% to about 15%, or from about 0.01% to about 10%, or in another implementation from about 0.1% to about 5%, by weight of the entire composition for oral care mouth.

In some implementations in accordance with the present invention, the composition may contain a thickening agent selected from natural and synthetic sources. In some implementations, the thickener may be selected from the group consisting of clay, laponite and mixtures thereof. In some implementations, the composition may further contain a thickener selected from the group consisting of carboxyquinolone, carrageenan, hydroxyethyl cellulose, water soluble salts of the whole is ulaznih esters, such as sodium carboxymethylcellulose, cross-linked carboxymethylcellulose, sodium hydroxyethylcellulose, cross-linked starch, natural gums such as gum karaya, xanthan gum, gum Arabic and tragacanth gum, magnesium aluminum silicate, silica, alkylated polyacrylates, alkylated cross-cross-linked polyacrylates and mixtures thereof.

Other possible thickeners include carbomer, hydrophobic modified carbomer, carboxymethylcellulose, cetyl/stearyl alcohol, sodium alginate, Gellan gum, acelerando Gellan gum, sodium hydroxypropyl starch phosphate, microcrystalline cellulose, microfiber cellulose, cross-linked polyvinylpyrrolidone, satellitesatellite, cross-linked sodium acryloyldimethyltaurate acid and copolymers and mixtures thereof.

The viscosity of the composition at the time of its reception may be the viscosity of the composition, or, put differently, the composition may have a stable viscosity. To ensure that the viscosity is considered stable, typically the viscosity varies by no more than about 5% after 30 days. In some implementations, the viscosity of the composition does not change by more than about 5% through about 30 days, more than about 10% after approximately 30 days, to Bo the it than approximately 20% after approximately 30 days, or more than approximately 50% after approximately 90 days. Since the problem of instability in viscosity over time is more pronounced in compositions with smaller amounts of water, in some implementations, the composition in accordance with the present invention can contain less than about 20% water, or less than, approximately 10% of the total water.

Gel mesh

Gel mesh can be applied in a composition for caring for the oral cavity. Gel mesh can be used for structuring composition to care for the oral cavity or to aid delivery of active substances, fragrances, or other reactive substances. Gel mesh can be used for structuring, which means, for thickening or provide the desired rheology for amorphous silica compositions for oral care mouth by itself or in combination with another thickener or amendment. The composition of the gel mesh has a rheology that can be useful for amorphous silica as amorphous quartz is more dense than some other abrasives or substances in a composition for caring for the oral cavity. Since amorphous quartz is heavier or more dense, it can fall or be deposited from the composition or solution is easier than other IU is its dense materials. This can occur if the composition is diluted with water. For example, if the means to care for your teeth use to clean the brush, it is diluted with water in the mouth. Rheology of dilute preparations for the care of teeth, the gel containing the grid contributes to the structuring of funds for care of teeth and may exceed the structuring of funds for care of teeth with a polymer or a more typical thickeners. Large rheology dilution is useful for maintaining suspension of amorphous silica and permission fuller participation of amorphous silica in the cleaning process. If a substance, such as abrasive, not suspended or does not remain in the composition after dilution, the cleaning efficiency, for example, the degree of purification from dental plaque can be reduced. Additionally, when more suspendirovanie abrasive or amorphous silica, the composition for the care of the oral cavity may contain fewer abrasives in General, as more abrasives are able to participate in the cleanup. The Figure 13 shows the data of PCR and RDA for compositions, structured gel nets, compared to compositions not structured gel nets, but thickened with the help of typical polymeric binders. As shown, the degree of PCR increases from 92,5 to 127,56 and 95,44 to 121,04 when IP is the use of gel mesh structure, containing 15% amorphous silica. This increase PCR for more than about 10%, about 15%, about 20%, or approximately 25% may occur due to the ability of the gel nets suspended greater amount of amorphous silica during cleaning. While the degree of purification increases abrasion remains in an acceptable range.

Compositions for the care of the oral cavity in accordance with the present invention may contain dispergirovannoyj gel sect. As used in this application, the term "gel stack" refers to a layered or bubble solid crystalline phase, which contains at least one amphiphilic fatty substance, at least one surfactant, and a solvent. Layered or bubble phase contains two layers consisting of a first layer containing fatty amphiphilic substance, and a second surfactant, alternating with a second layer containing the solvent. For the formation of layered crystalline phase amphiphilic fatty substance and the second surface-active agent should be dispersed in the solvent. The term "solid crystalline substance," as used in this application refers to a layered structure or bubble phase, which is formed at a temperature lower than the temperature of Rapla the chains in the gel layer in the grid, containing one or more amphiphilic fatty substances. Gel mesh suitable for use in the present invention, described in more detail in application U.S. US 2008/0081023 A1, which describes substances, methods of production and application of gel nets. Additionally, US 2009/0246151 A1 also describes a gel mesh and a method of producing compositions containing gel of the grid.

Gel mesh in a composition for caring for the oral cavity can be used for structuring composition to care for the oral cavity. Structuring secured gel mesh, provides the desired rheology or viscosity by thickening compositions for oral care mouth. The structuring can be carried out without the need for polymeric thickeners, however, polymeric thickeners or other agents can be applied in addition to gel the grid for structuring composition to care for the oral cavity. Since amorphous silica does not provide thickening or the extent of thickening, as a typical precipitated silica, salustiana compositions for the care of the mouth may occur to a greater extent by applying more gel stacks, which are used for structuring composition to care for the oral cavity. Little or no influence amorphous silica has on the viscosity or zagustevaniya to care for the oral cavity can also provide useful effect, consisting in creating compositions for oral care mouth with gel mesh or other system thickeners, and then adding an amount of amorphous silica, which is preferably in the absence of the need for re-regulation of the level of thickening, which may be required if the regulation of the amount of precipitated silica.

Component gel mesh in accordance with the present invention contains at least one amphiphilic fatty substance. As used in this application, "amphiphilic fatty substance" refers to a compound containing a hydrophobic "tail" group and a hydrophilic "head" group, that does not make the connection water-soluble (immiscible), where the connection also has a network neutral charge at pH compositions for oral care mouth. Fatty amphiphilic substance may be selected from the group consisting of fatty alcohols, alkoxycarbonyl fatty alcohols, fatty phenols, alkoxycarbonyl fatty phenols, fatty amides, alkoxycarbonyl fatty amides, fatty amines, fatty alkylmethacrylamide, fatty alkoxysilane amines, fatty carbamates, fatty aminoacids, fatty acids, alkoxycarbonyl fatty acids, fatty diesters, fatty sorbitolovy esters, sugar fatty esters, methylglucose esters, fatty glycol esters, mono -, d is - and triglycerides, polyglyceryl fatty esters, alkylglycerol esters, propylene glycol esters of fatty acids, cholesterol, ceramides, fatty silicone waxes, fatty glucosamine, phospholipids, and combinations thereof. Acceptable amphiphilic fatty substances include a combination of cetyl alcohol and stearyl alcohol.

Gel mesh also contains a surfactant. One or more surfactants combined with fatty amphiphilic substance and oral media with the formation of the gel mesh in accordance with the present invention. Surfactant typically vodorostvorima or miscible with the solvent or oral media. Acceptable surfactants include anionic, zwitterionic, amphoteric, cationic and nonionic surfactants. In one implementation, anionic surfactants such as sodium lauryl sulfate, are preferred. Surfactants can be a combination of more than one type surfactants, such as anionic and non-ionic surfactant. Gel net will likely also contain solvents, such as water or other appropriate solvents. Solvent and surfactant together in the swell W is REGO amphiphilic substances. This, in turn, leads to the formation and stability of the gel mesh. In addition to the formation of the gel mesh, the solvent can help prevent hardening of the composition means for care of the teeth under the influence of air and provide a feeling of moisture in the mouth. The solvent as used in this application refers to an acceptable solvents that can be used instead of or in combination with water in the formation of the gel mesh in accordance with the present invention. Acceptable solvents for the present invention include water, food polynuclear alcohols, e.g. glycerin, diglycerin, triglycerin, sorbitol, xylitol, butyleneglycol, erythritol, polyethylene glycol, propylene glycol, and combinations thereof. Sorbitol, glycerin, water, and combinations thereof are preferred solvents.

For the formation of the gel mesh of the composition for the care of the oral cavity can contain amphiphilic fatty substance in an amount of from about 0.05% to about 30%, preferably from about 0.1% to about 20%, and more preferably from about 0.5% to about 10%, by weight of the composition for the care of the oral cavity. The amount of amphiphilic fatty substances will be selected on the basis of the formation of the gel mesh and compositions for oral care RT is. For example, the composition for the care of the oral cavity, containing a small quantity of water, may require approximately 1% of the amphiphilic fatty substances, while composition for oral care mouth with large amounts of water may require 6% or more amphiphilic fatty substances. The amount of surfactant and solvent required for the formation of the gel grid will also vary based on the selected substances, the function of the gel mesh and the number of amphiphilic fatty substances. Surfactant as part of phase gel mesh is typically present in an amount of from about 0.01% to about 15%, preferably from about 0.1% to about 10%, and more preferably from about 0.3% to about 5%, by weight of the composition for the care of the oral cavity. In some implementations, use a diluted solution of surfactant in water. In one implementation, the amount of surfactant is chosen based on the level of foaming is desired in the composition for oral care mouth, and irritation caused by surface-active substance. The solvent may be present in amounts acceptable to obtain a gel of mesh in connection with fatty amphiphilic substance and a surfactant is a substance in accordance with the present invention. Compositions for oral care mouth can contain at least about 0.05% solvent by weight of the composition for the care of the oral cavity. The solvent may be present in the composition for the care of the oral cavity in an amount of from about 0.1% to about 99%, from about 0.5% to about 95%, and from about 1% to about 90%.

Humidifier

A humidifier can help prevent hardening of the composition means for care of the teeth under the influence of air and provide a feeling of moisture in the mouth. Humidifier or additional solvent can be added to the phase of the carrier acceptable to the oral cavity. Acceptable moisturizers in the present invention include water, edible polyhydric alcohols such as glycerin, sorbitol, xylitol, butylene glycol, polyethylene glycol, propylene glycol, and combinations thereof. Sorbitol, glycerin, water, and combinations thereof, are preferred moisturizers. The humectant may be present in an amount of from about 0.1% to about 99%, from about 0.5% to about 95%, and from about 1% to about 90%.

Surfactants

Surfactant may be added to the composition means for care of the teeth. Surfactant that is usually called saponification agents, can facilitate the cleaning or foaming composition means for care of the teeth. Acceptable surface-active substances are substances which are stable and suitable foaming in a wide range of pH values. Surfactant may be anionic, nonionic, amphoteric, zwitterionic, cationic or mixtures thereof.

Examples of anionic surfactants useful in this application include water-soluble salts of alkyl sulphates containing from 8 to 20 carbon atoms in the alkyl radical (for example, sodium alkylsulfate) and soluble salts from sulphonated of monoglycerides of fatty acids containing from 8 to 20 carbon atoms. Sodium lauryl sulfate (SLS) and sodium coconut monoglyceride the sulfonates are examples of anionic surfactants of this type. Examples of other acceptable anionic surfactants are sarcosinate, such as sodium lauroyl of sarcosinate, taurate, sodium lauryl sulfoacetate, sodium lauroyl isetionate, sodium Laureth carboxylate, and sodium dodecyl of bansilalpet. Can also be used a mixture of anionic surfactants. Many acceptable anionic surfactants described Agricola et al., U.S. patent 3,959,458, issued may 25, 1976, In some implementation, eniah, composition for the care of the oral cavity may contain anionic surfactant at a level of from about 0,025% to about 9%, from about 0.05% to about 5% in some realizations and from approximately 0.1% to approximately 1% in other implementations.

Other acceptable surface-active substance is a substance selected from the group consisting of sarcosinate surfactants, isethionate surfactants and taurate surfactants. Preferred for use in this application are alkali metal salts or ammonium salts of such surface-active substances, for example sodium and potassium salts: lauroyl sarcosinate, myristoyl sarcosinate, Palmitoyl sarcosinate, stearoyl sarcosinate and oleoyl sarcosinate. Sarcosinate surfactant may be present in the compositions in accordance with the present invention from about 0.1% to about 2.5%, or from about 0.5% to about 2% by weight of the entire composition.

Cationic surfactants useful in the present invention include derivatives of aliphatic Quaternary ammonium compounds containing one long alkyl chain containing from about 8 to 18 carbon atoms, e.g. the, of the lauryl ammonium chloride; pyridinium chloride; cetyltrimethylammonium bromide; di-isobutylphthalate-dimethylbenzylamine chloride; coconut, alkyltrimethylammonium nitrite; pyridinium fluoride; etc, the Preferred compounds are the Quaternary ammonium fluorides described in U.S. patent 3,535,421, October 20, 1970, issued by Briner et al., where these Quaternary ammonium fluorides have detergent properties. Certain cationic surfactants can also act as germicides in the compositions described in this application.

Nonionic surfactants that may be used in the compositions in accordance with the present invention include compounds obtained by the condensation alkalinising groups (hydrophilic in nature) with an organic hydrophobic compound which may be aliphatic or alkylaromatic in nature. Examples of acceptable non-ionic surfactants include Pluronic, condensates of polyethylene oxide with alkyl phenols, products obtained by condensation of ethylene oxide with the reaction product of propylene oxide and Ethylenediamine, condensates of ethylene oxide aliphatic alcohols, acids and esters, long-chain tertiary aminoxide, long-chain tertiary phosphine oxides, long-chain diallylsulfide and MESI of such substances.

Zwitterionic synthetic surfactants useful in the present invention include derivatives of aliphatic Quaternary ammonium, fofanah and Solonevich compounds in which the aliphatic radicals can be unbranched or branched and in which one of the aliphatic substituents contains from about 8 to 18 carbon atoms and one contains an anionic water-solubilizing group, e.g. carboxy, sulfonate, sulfate, phosphate or phosphonate.

Acceptable betainovuyu surfactants described in U.S. patent 5,180,577 issued Polefka et al., January 19, 1993, a Typical alkyldiphenylamine include derivation or 2-(N-decyl-N,N-dimethylammonio)acetate, Comblain or 2-(N-Kok-N,N-dimethylammonio)acetate, myristylated, palmitoylation, laurylether, zeilboten, zeilboten, stearylamine etc. Aminobutane illustrated as colligative, cocamidopropylbetaine, lauramidopropyl etc. Preferred betaines are preferably cocamidopropylbetaine and, more preferably, lauramidopropyl.

Precipitated silica has a tendency to decrease foaming compositions for oral care mouth. On the contrary, amorphous quartz, with its low reactivity, did not inhibit foaming or not inhibited in peniana to the extent of precipitated silica. The lack of boundaries between the components of the surface-active substances can affect the amount of surface-active substances, which in turn can affect other variables. For example, if you require a smaller amount of surfactant to achieve foaming acceptable to the consumer, it can reduce irritation (known to users in a negative property SLS), or can reduce the pH of the composition, which may allow better absorption of fluoride.

In some implementations, the polymeric mineral surface active agents are added to reduce the negative aesthetic properties of these compounds. Polymeric mineral surface active agents can be organophosphate polymers, which in some implementations represent alkylphosphate esters or their salts, ethoxylated alkylphosphate esters and their salts, or methoxylamine alkylphosphate, or a mixture alkylphosphate esters or their salts. In some implementations, the polymeric mineral surface active agents can be polycarboxylate or polyphosphates or copolymers of polymeric carboxylates, such as Gantry.

In some implementations, the composition may contain amorphous silica and essentially not containing the ü SLS. Essentially not contain means that they contain less than about 0.01%, by weight of the composition. In some implementations, the composition may further contain a surfactant other than SLS, which are selected from the group consisting of nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, zwitterionic surfactants and mixtures thereof. In some implementations, the composition may further contain chelant. In some implementations, the surfactant may be an amphoteric surfactant such as betaine, for example. In some implementations, the composition may have a PCR of at least about 80. In some implementations, the surfactant may be at least about 50% available. In some implementations, the composition contains less than 3% surfactant, by weight of the composition. In some implementations, the composition may further comprise a source of peroxide and/or enzymes. Some implementation may be a method of treatment of a condition of dry mouth by introducing into the oral cavity of the subject composition and to care for the oral cavity, containing amorphous silica, where the composition essentially contains no sodium lauryl sulfate.

Method of use

The present invention also relates to methods of cleaning and polishing teeth. The method of application in this sauce includes the contacting of the surfaces of the teeth enamel of the subject and of the mucous membrane of the oral cavity with compositions for the care of the oral cavity in accordance with the present invention. The treatment can be cleaned with a brush tool for care of teeth or rinsing suspension for care of teeth or mouth rinse. Other methods include contacting local gel oral, spray for the mouth, tooth paste, means for care of teeth, tooth gel, tooth powders, tablets, subgingival gel, foam, mousse, chewing gum, lipstick, sponge, floss, vaseline or gel product for dentures or other forms with teeth or the mucous membrane of the oral cavity of the subject. Depending on the implementation, the composition for the care of the oral cavity can be used as often as toothpaste, or may be used less frequently, such as weekly, or used by the professional in the form of pastes or other intensive treatment.

Additional data

In Figures 7-13 provided more detailed data is Astelin material properties of amorphous quartz, as well as its compatibility with other components of the composition for the care of the oral cavity, and its cleaning ability.

In Figures 7A and 7B shows the compositions and the corresponding data for the compatibility of divalent tin, zinc and fluoride. Figure 7A shows the composition for the care of the oral cavity, the composition And contains precipitated silica and the composition contains amorphous quartz. Figure 7B shows the data compatibility for both part a and for part V At 25°C and 40°C in 2 weeks, 1 month and 2 months, given as % compatibility. The data in Figure 7 show that the composition of the amorphous silica provides excellent stability and compatibility with the divalent tin, zinc and fluoride.

It may be desirable to have a composition for oral care mouth with salts of zinc, where the composition has a content of zinc in excess of approximately 82%, 85%, 87 or 90% after two weeks of storage at 25°C. May be desired that the content, amounting to 82%, 85%, 87%, or 90% remained before use by the user. Therefore, content can be measured before use. Before use may mean that the product has been received, Packed and distributed for storage or the user, but before the user has applied this product. Conditions and storage temperatures during this period will be once ichatusa.

It may be desirable to have a composition for oral care mouth with fluoride ions, where the composition has a content of fluoride in excess of approximately 88%, 90%, 91%, 92%, 93% or 94% after two weeks of storage at 25°C. may Also be desired that the content of fluoride remained greater than approximately 88%, 90%, 91%, 92%, 93% or 94% before use. For some compositions, the fluoride can be greater than 95% before use.

It may be desirable to have a composition for oral care mouth with salts of divalent tin, where the composition has the compatibility or the content of divalent tin in excess of approximately 55%, 60%, 65%, 70%, 75%, 80%, 85% or 90% after two weeks of storage at 25°C. Also, it may be desirable to compatibility or the content of bivalent tin remained in excess of approximately 55%, 60%, 65%, 70%, 75%, 80%, 85% or 90% before use. In some compositions, the content, or the compatibility of divalent tin can be at least approximately 92%. The compositions of amorphous silica with divalent tin compatibility divalent tin is typically from about 20% to about 50%, from about 25% to about 45%, or from about 30% to about 40% to exceed the compatibility for compositions with comparable amounts deposited to the of amnesia and divalent tin.

The Figure 8 shows the compatibility of divalent tin as a function of load. The greater the quantity of precipitated silica, the lower the amount of free or available divalent tin. In the table demonstrated that the loss of divalent tin for precipitated silica (Z-119) is 0,0081 g/g Z-119 (or 80 ppm/1% Z-119 load). On the contrary, the loss of divalent tin for amorphous silica is 0.001 g/g Tecosil 44CSS (or 10 ppm/1% Tecosil 44CSS load). In some implementations, depending on the surface area, loss of divalent tin for amorphous silica is from about 5 to about 50 ppm/1% load amorphous silica, from about 7 to about 30 ppm/1% load amorphous silica, from about 8 to about 20 ppm/1% load amorphous silica, or from about 10 to about 15 ppm/1% load amorphous quartz.

In Figures 9A and 9B shows a peroxide-containing composition and data compatibility. Figure 9A shows the peroxide-containing compositions with different besieged by silica and amorphous quartz. Figure 9B shows the compatibility with the peroxide compositions at 40°C, initially, after 6 days and 13 days. The data show excellent compatibility peroxide with an amorphous quartz compared to the deposited silica. In some the sushestvennih, compatibility peroxide is at least about 50%, at least about 60%, at least about 70%, at least about 80%, or at least approximately 85% in about 13 days at 40°C. in Other words, in some implementations, after approximately 13 days at 40°C, can be at least about 50%, 60%, 70% or 85% peroxide or oxidizing agent.

The method of preparation of samples the following: transfer 18 grams of peroxide gel base in plastic container; mix thoroughly 2 g of silica with a spatula; measure the pH of the mixture; divide the mixture into two equal portions and place one portion at 25°C and the other at 40°C; place the sample in a climatic chamber at 25°C and 40°C. Analysis of samples carried out as follows: take the original sample for analysis on peroxide; remove samples from climatic chambers 5 and 12 day and allow me to establish equilibrium within 1 day; remove 0.2 g samples from each mix and place the remaining samples back in the climatic chamber; perform analysis on peroxides as follows: weigh 0,2000 g (+/-0,0200 g) peroxide gel in a plastic Cup, 250 ml; add a stir bar and 100 ml of 0.04 NH2SO4, cover parafilm, stir for at least 10 minutes; add 25 ml of 10% KI solution and 3 drops of NH4-molybdate and stir an additional 3 to 20 minutes; analyze autocaravanas with 0,1N Na-thiosulfate. Compatibility is defined as the peroxide percentage in 13 days at 40°C, divided by the initial peroxide percentage, then multiply by 100. Specialist in the art will know that the product is placed at 40°C, shows increased shelf life. That is, for example, one month at 40°C will approximately correspond to eight months at room temperature.

Figure 10A shows the compositions a to E, which is a composition for the care of mouth cavity containing amorphous silica and peroxide. Figure 10B shows the change in brightness (δL) of the samples enamel cows after a given amount of movement of the brush for two of the songs on Figure 10A, which contain amorphous silica and peroxide, for comparison, a composition for amorphous silica, but without peroxide (composition F), and a composition that does not contain any amorphous quartz or peroxide (Crest Cavity Protection Toothpaste). The data demonstrate that the combination of amorphous silica and peroxide provides superior cleaning and whitening. In some implementations, the Delta L may exceed about 4.5 at 50 movements, to exceed approximately 6.0 with 100 movements, to exceed approximately 9,0 200 movements, or to exceed approximately at 400 15,0 movements. In some implementations, the Delta L can about the approximately 50% to approximately 100% to exceed Crest Cavity Protection Toothpaste. The method consists in the following: substrates bovine enamel were mounted and stained according to the traditional PCR Protocol described ..Stookey, et al., /. Dental Res., 61, 1236-9, 1982. A group of 6 plates separated for each branch of treatment, where each group had approximately the same background value L. 1:3 slurry of therapeutic paste was obtained and coated substrates bovine enamel was cleaning brush with 50, 100, 200 and 400 moves from the reference force of 150 grams, shown during brushing. After brushing with every number of movements, the substrates were photographed and analyzed for values of L. the Change of values of L was calculated as follows: δL=Lafter cleaning- Lbefore cleaningand compared statistically using LSD.

Figure 11A shows the compositions of funds for the care of teeth, containing precipitated silica or amorphous quartz, and Figure 11B shows the corresponding data of the senses of the consumer. Test sensation of the user has been conducted among the nine subjects who brushed their teeth brushed every product twice and provided feedback through written responses to questions that pertained to the display of flavors and mouth feel. The subjects were asked to provide feedback regarding their sensations during use, immediately after application and after 15 minutes of th is product applications. As shown in Figure 11B, in General, the composition containing amorphous quartz, offer excellent aromatic intensity, freshening, teeth feeling smooth and clean in the mouth compared to precipitated silica.

The Figure 12 shows additional illustrative formulations of the compositions for the care of mouth cavity containing amorphous quartz. The compositions include compositions containing gel mesh, a combination of amorphous silica with precipitated silica and calcium carbonate compositions that do not contain SLS, and compositions that can be used as a prophylactic pastes or who don't use on a daily basis.

Figure 13A shows the composition based on sodium fluoride, in which the compositions a and b contain precipitated silica with traditional thickeners, compositions C and D contain amorphous silica with traditional thickeners, and mixtures E and F contain amorphous silica gel with mesh. Figure 13B presents a table of values of RDA and PCR for compositions based on sodium fluoride, presented in Figure 13A, where it is shown that the use of amorphous silica improves the cleaning ability of the composition and that the application of the gel mesh improves the cleaning ability of the composition even more, while maintaining acceptable abrasiveness. Figure 13C shows the composition based on fluoride divalent about the ova in the implementation, similar to those shown in Figure 13A. Figure 13D shows the corresponding values of the RDA for songs in the Figure 13C, indicating that the use of divalent tin can reduce the abrasiveness, demonstrating the potential strengthening of the teeth compounds with divalent tin.

Non-limiting examples

Composition means for care of the teeth illustrated in the following examples, which illustrate a specific implementation of the compositions of funds for care of teeth in accordance with the present invention, but not intended to be limiting thereof. Other modifications can be made by the specialist in the art without going beyond the gist and scope of the present invention.

Example I. A-D are typical compositions for the care of mouth cavity containing amorphous quartz. In the structure shown In the combination of amorphous quartz and precipitated silicas, and composition D is a combination of amorphous silica and calcium carbonate:

Monitoroff sodium/tr>
IngredientAInD
Sodium fluoride0,240,24--
--1,131,13
Sorbitol59,5859,5859,5824,00
Glycerin----
Silica (Zeodent 119)-15,00-
Silica (Zeodent 109)---
Amorphous quartz (Teso-Sil 44CSS)15,005,0015,0010,00
Calcium carbonate---30,00
Trehosnovnoy sodium phosphate1,101,101,100,40
Flavouring substance0,810,810,811,00
Sodium carboxymethylcellulose0,750,750,751,30
Carragenan----
Xanthan gum----
Titanium dioxide0,530,530,53-
Monoosnoc sodium phosphate0,420,420,420,10
Carbomer 9560,300,300,30-
Saccharin sodium0,130,130,130,20
Dyes FD&C0,050,050,05-
Sodium lauryl sulfate4,004,004,007,00
WaterEnoughEnoughEnoughEnough
100,00100,00100,00100,00

Example II. A-F are typical compositions for the care of mouth cavity containing amorphous silica with cationic antimicrobial agents:

IngredientAndInDEF
Sodium fluoride---- -0,24
Fluoride divalent tin0,450,450,450,450,45-
Chloride divalent tin1,161,161,16---
Gluconate sodium1,061,061,061,061,06-
The zinc citrate0,530,530,53---
Lactate zinc---2,502,502,00
The pyridinium chloride--- --0,25
The sodium hexametaphosphate---13,0013,00-
PEG---7,007,007,00
Sodium tripolyphosphate--5,00--5,00
Phytic acid0,800,80----
Sorbitol38,0738,0738,07--50,00
Glycerin---55,33 55,338,00
Silica (Zeodent 119)----5,00-
Silica (Zeodent 109)-7,505,00---
Amorphous quartz (Teso-Sil 44CSS)15,007,5010,0015,0010,0015,00
Flavouring substance1,201,201,201,001,001,00
Sodium carboxymethylcellulose1,301,301,30--1,30
Carragenan-0,70 0,700,600,60-
Xanthan gum---0,250,250,25
Titanium dioxide0,500,500,50---
Saccharin sodium0,250,250,250,250,250,25
Dyes FD&C---0,050,050,05
Sodium lauryl sulfate7,507,507,503,503,503,50
WaterDostat. Nr.To the tat. Nr.Dostat. Nr.Dostat. Nr.Dostat. Nr.Dostat. Nr.
100,00100,00100,00100,00100,00100,00

The dimensions and values described in this application should not be construed as strictly limited to the exact numerical values. Instead, unless otherwise specified, each such dimension is intended to refer to as the present value and a functionally equivalent range around this value. For example, the size described as "40 mm"is intended to mean "about 40 mm".

All documents cited in the detailed description of the present invention, in their relevant parts, included in this application by reference; the citation of any document should not be construed as an assumption that it represents the prior art relative to the present invention. To the extent that any meaning or definition of a term in this document contradicts any meaning or definition of the same term in a document incorporated by reference, valueField definition assigned to such term in this document will govern.

While the specific implementation of the present invention have been illustrated and described, a person skilled in the art it will be obvious that various other changes and modifications can be made, without departing from the scope and essence of the present invention. Therefore, the present invention is intended to ensure that in the volume formula, which is attached, included all such changes and modifications are included in the scope of the present invention.

1. Composition for the care of mouth cavity containing amorphous silica and a source of ions of divalent tin, the average particle size of amorphous silica is from 1 to 20 microns.

2. The composition according to claim 1, characterized in that the ion source of divalent tin fluoride is divalent tin.

3. The composition according to claim 1, characterized in that the ion source of divalent tin salt is divalent tin selected from the group consisting of chloride divalent tin, ferrous gluconate tin acetate divalent tin tartrate divalent tin oxalate divalent tin, ferrous sulfate tin, citrate divalent tin, malonate divalent tin, ferrous lactate, tin, phosphate divalent tin, the feast of the phosphate divalent tin, bromide of divalent tin, ferrous iodide, tin and combinations thereof.

4. The composition according to claim 1, characterized in that the number of ions of divalent tin is from 50 million-1to 15,000 million-1.

5. The composition according to claim 1, characterized in that the number of ions of divalent tin is less than 10,000 million-1.

6. The composition according to claim 1, wherein the percentage content of ions of bivalent tin after two weeks storage at 25°C relative to the initial content of ions of divalent tin in the composition exceeds 80%.

7. The composition according to claim 6, wherein the percentage content of ions of bivalent tin before use relative to the initial content of ions of divalent tin in the composition exceeds 80%.

8. The composition according to claim 7, wherein the percentage content of ions of bivalent tin before use relative to the initial content of ions of divalent tin in the composition exceeds 90%.

9. The composition according to claim 1, characterized in that it further comprises chelant.

10. The composition according to claim 9, characterized in that chelant selected from polymeric organophosphate compounds, including ethoxylated and methoxylamine mono - or dialkylphosphate or phosphonates.

11. The composition according to claim 1, Otley is audacia fact, which further contains one or more essential oils.

12. The composition according to claim 11, characterized in that it contains two essential oils, but the first one essential oil selected from the group consisting of acyclic or cyclic structures, and the second one essential oil selected from the containing loop structures.

13. The composition according to claim 1, characterized in that it further comprises a gel mesh.

14. The composition according to claim 1, characterized in that it further contains a source of peroxides.

15. Composition for the care of mouth cavity containing amorphous silica, a source of ions of divalent tin, one or more essential oils and chelant, the average particle size of amorphous silica is from 1 to 20 microns.

16. The composition according to claim 1, characterized in that it further comprises a source of zinc ions and chelant.

17. Caring for the oral cavity, including the state, which is introduced into the oral cavity of a subject a composition according to any one of claims 1 to 16.



 

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7 cl, 7 tbl, 2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed group of inventions relates to composition for oral cavity care and methods of its application. Claimed is composition for oral cavity care, which contains: arginine, in free form or in form of salt in amount from 0.1 to 20 wt % of total composition weight; triclosan in amount from 0.01 to 5 wt % of total composition weight; anionic polymer, which is a copolymer of methyl vinyl ether and maleic anhydrate; anionic surfactant in amount from 0.01 to 10 wt % of total composition weight; soluble fluoride salt in amount from 0.01 to 2 wt % of total body weight, in order to provide 50-25000 ppm of weight of fluoride ions, in which soluble fluoride salt or source of fluoride ions is selected from sodium fluoride, sodium monofluorophosphate and their mixtures; and abrasive material, which contains fraction of minor particles, constituting at least about 5 wt % of total composition weight, and in said fraction minor particles have average diameter d50 smaller than 5 mcm.

EFFECT: application of composition for oral cavity care along with improved delivery of antibacterial agent provides additional advantages in acceleration of remineralisation and restoration of precarious affection foci due to combination of fluoride and arginine, as well as due to application of finely disperse abrasive as composition component.

11 cl, 1 tbl, 7 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions relates to compositions for oral cavity care and to methods of their application. Claimed are compositions for oral cavity care, which contain effective amounts of arginine in free or salt form, anionic surface active substance, halogenated diphenyl ether, anionic polymer, and precipitated calcium carbonate, which has d50 from approximately 0.5 to approximately 3 micrometres.

EFFECT: compositions are efficient, in particular, for reduction of bacteria adherence to tooth surface in subject's oral cavity, in addition, chemical composition provides favourable effect in activation of remineralisation, elimination of pre-caries damage and strengthening healthy state of oral cavity along with intensification of taste properties of formulation of preparation for oral cavity care and increase of general acceptability pf product for consumers.

33 cl, 1 tbl, 8 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to therapeutic dentistry, and is intended for treatment of pulpitis, apical and marginal dental periodontitis. Drug processing of root canal is carried out. Canal is dried. After that, root canal of tooth is filled with liquid No 1 - solution of subacid magnesium fluoric silicate from composition of "Dentin-hermetising liquid". Active needle electrode of device for carrying out electro- or depot phoresis is introduced into canal and transcanal electrophoretic introduction of ions, contained in liquid, into dentin tubes of tooth root is performed. Amount of electricity, passing through tissues of tooth root tissues, constitutes from 1 to 5 mA X min, with current value from 0.1 to 1 mA. After that root canal is dried with air and electrophoresis of liquid No 2 - alkaline suspension of highly-dispersive calcium hydroxide from composition "Dentin-hermetising liquid" is carried out at the same parameters as the first liquid. Root canal is dried with air and filled by traditional method.

EFFECT: method makes it possible to reduce number of complications and increase efficiency of treatment of pulpitis, apical and marginal periodontitis due to deep transcanal electrophoretic fluoridation of tooth root dentin.

7 dwg, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to therapeutic dentistry, and can be used in treatment of deep dental caries. For this purpose preparation of caries cavity with its further antiseptic processing with ozone-oxygen mixture possessing high bactericidal effect is carried out. Ozone concentration in mixture constitutes 30-40 mcg/ml. Processing is carried out for 25-40 seconds. After that, self-hardening radiopaque material, containing calcium hydroxide "Life" is used as medicinal padding and filling is performed.

EFFECT: method makes it possible to perform tooth filling during the first visit due to antiseptic processing not only on the surface of caries cavity, but in dentin tubes.

1 tbl, 2 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely therapeutical stomatology and may be used for treating the patients suffering generalised periodontitis. That is ensured by periodontal care and antiseptic preparation, topical treatment with "Lesnoy Balsam" involving applications to a region of inflammation in an amount of 0.05-0.2 g and introduction into gingival pockets. Length of the procedures is 15 minutes twice a day; the therapeutic course is 5-6 days: the general treatment includes the preparation "Ginkoum" 1 capsule three times a day; the therapeutic course is 5 weeks.

EFFECT: invention enables a high therapeutic effect by blocking pathogen flora, improved regional gingival haemodynamics, wound healing and epithelising actions, reduced perivascular oedema and vascular metabolic improvements with no discomfort to the patient.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine. What is presented is a compound for preparing an oral rinse for treating radio-induced xerostomia in the following proportions of the ingredients in water 200 ml: ethyl cellulose 0.5 - 0.9 g, calcium hydrophosphate 0.1 - 0.3 g, potassium hydrophosphate as a buffer system 0.4 - 0.6 g, succinic acid 0.10 - 0.14 g.

EFFECT: invention provides the improved clinical effectiveness in radio-induced xerostomia ensured by the recovered physical-chemical properties of saliva and normalised processes of solid tissue mineralisation.

2 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely surgical dentistry and physiotherapy, and may be used in dental implantology for preventing postoperative infectious-inflammatory complications following bone tissue surgeries. For this purpose, the surgical intervention is followed by blood sampling from an incisional wound to be treated with ozonised gas of the ozone concentration of 20±2 mg/l. Then blood is mixed with a bone autograft and treated with ozonised gas of the ozone concentration of 20±2 mg/l. The prepared autograft is introduced into an implantation and sinus lifting site. From the second postoperative day, the incisional field is exposed to extremely high frequency for 3-6 days for 10-20 minutes. For 5-7 days, the incisional field is treated with ozonised distillate of the ozone concentration of 1-2 mg/l.

EFFECT: method enables effective prevention of postoperative infectious-inflammatory complications by improving osteogenesis and accelerating implant integration ensured by the ozone treatment in specific regimen and environment.

3 cl, 2 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to dual tooth brushing compositions and methods for using them. The presented dental care composition contains a first ingredient containing a calcium source in the form of dicalcium phosphate, a second ingredient containing at least one anion source wherein one of the anion sources represents a fluorine ion source wherein at least the second ingredient contains arginine or its salt with the first and second ingredient are separated from each other until supplied and combined for dental application. There are also presented a method of oral care and a method of elimination or relief of discomfort and pain related to dentine hypersensitivity with the use of said composition.

EFFECT: formulation of the first and second ingredients provides the composition storage stability, as well as oral delivery of the high concentrations of all the active agents that enables implementing such favourable effects, as a lower probability of erosion and caries, lower enamel hypersensitivity.

16 cl, 1 tbl, 1 ex

FIELD: medicine.

SUBSTANCE: group of inventions refers to oral care compositions and methods for using them. The presented oral care composition contains an effective amount of arginine bicarbonate and a fine particle fraction containing at least 5 % of the formulation weight. The particles in the fine particle fraction have d50 less than approximately 5 mcm with the fine particle fraction specified in deposited calcium carbonate, silicone dioxide and their mixtures. The composition may be used, in particular, for improved dentin defect closure in the patient's oral cavity. A version of the composition to be applied in treating sensitive teeth contains arginine bicarbonate and an abrasive substance specified in deposited calcium carbonate, silicone dioxide and their mixtures wherein the abrasive substance contains said fine particle fraction.

EFFECT: said composition oral care compositions and methods for using them are effective, including for tooth and oral cleansing, reducing or suppressing dental deposit accumulation, reducing a level of acid producing (cariogenic) bacteria, remineralising teeth, reducing or suppressing gingivitis, reducing dentin hypersensitivity.

38 cl, 1 tbl, 6 ex

Saliva substitute // 2472515

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry, namely a saliva substitute. The egg white saliva substitute possessing the chemical, rheological and physiological properties analogous to those of natural saliva with the saliva substitute additionally containing at least one substance enabling regulating viscosity, and specified in: cellulose derivatives, gum resin, non-cellulose polymers or other polymers, e.g. hyaluronic acid or polyols. The use of the saliva substitute for deficient saliva compensation. The use of the saliva substitute for maintaining required residual oral moisture with deficient saliva. A packing containing the saliva substitute.

EFFECT: saliva substitute has the composition and the properties maximally approached to natural human saliva for maintaining required residual oral moisture with deficient saliva.

7 cl, 1 ex

FIELD: medicine.

SUBSTANCE: invention relates to cosmetic industry and presents preparation for head skin and hair care in form of shampoo, which includes one or several surface-active substances, foam stabiliser, consistent additive, preservative, PH stabiliser, target additive for hair structure improvement, vitaminous additive, conditioner, water softener, odorant and water, which is characterised by fact, that as vitaminous addition it contains freshly squeezed juice of Lucerne, obtained by method of mechanic single pressing with multistage loading with the following separation of cytoplasmic juice fraction, and components in preparation are in definite wt % ratio.

EFFECT: invention ensures increased degree of biological activity degree finished preparation for head skin and hair care, vitaminising, moistening, nourishment of head skin and hair.

2 cl, 7 tbl

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