Method for recovering sensor-motor function of central nervous system and peripheral nerves

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to neurology, neurosurgery and rehabilitation, and may be used to recover the sensor-motor function of the central nervous system and peripheral nerves. The therapy is three-staged. At the first stage, at least two hollow electrodes made of biologically neutral conductive material in a proximal and distal direction from a nerve injury are implanted into the nerve. The second stage involves at least one course of a focused extracorporeal shock-wave therapy consisting in at least five sessions in a combination with intraneural electric stimulation and intraneural ionic medication aiming at stimulating the growth of peripheral nerve fibre axons and the regeneration of Schwann cells forming the medullary sheath. At the third stage, the implanted electrodes are removed, and at least one session of transcutaneous electric stimulation with one-step electric myoneurography is conducted to coordinate neural pulses passage through the newly formed peripheral nerve synapses.

EFFECT: method provides the high therapeutic effectiveness in case of injuring up to 90% of neural synapses, reduced length of rehabilitation up to the complete recovery in the patient with no contra-indications and a possibility of the outpatient care.

6 ex

 

The invention relates to medicine, namely to neurology, neurosurgery and rehabilitation, and can be recommended for the treatment of post-traumatic, surgical and degenerative injuries of the Central and peripheral nervous system, including, paresis, paralysis of the Central and peripheral nervous systems, post-operative complications, neuralgia, neuropathy, etc.

In neurosurgical practice to date, the treatment of such pathologies traditional therapeutic and surgical techniques is ineffective.

The prior art methods of treatment of such pathologies.

So, from the description to the patent of Russian Federation №2316334 (published 10.02.2008) known activation method of lost motor functions under the control of the effectiveness of their recovery, including the use of stimulation of motor points (MT) on the patient's body, neurophysiological studies and physical therapy, characterized in that when the Central nervous system additionally conduct initial neurophysiologic study method electroneuromyography (ENMG), thus take into account the following parameters: the amplitude of the M response of muscle fibers, the latent period of the M-response of muscle fibers, the speed of conduction of the impulse through the nerve fiber, the minimum latency the period F-wave and spend a combined stimulation of the MT method acupressure with further nutrient impacts according to the following algorithm: if the injured spinal cord stimulates MT on the back surface of the body and extremities located proximally above and below the injury site, then MT distal legs and finally - MT in the projection of the injury and when the injury brain stimulate MT head and neck, then MT rear surface of the body and finally - MT distal upper and lower extremities, while stimulation spend the first method acupressure MT strictly perpendicular to the surface of the skin at the location of MT on the patient's body, then a stimulation combined with consistent application of the elixir of biogenic stimulators, representing a potion consisting of the 10%aqueous solution of aloe juice (Aloe), 10%aqueous extract of Jasmine (Jasminum L), 2%aqueous solution of the alcoholic extract of propolis and 25%aqueous solution of Dimexidum, taken in a volumetric ratio of 1:3:1:1, in the order specified algorithm to select the MT, and incubated for 20-30 minutes

In addition, from the abstract to the application of the Russian Federation No. 2001102533 (published 27.11.2002) known way to restore the functions of the nervous system when it is damaged, in which make a preliminary determination of the severity of the dysfunction and after establishing indications for stimulation conduct a number of sessions transcutaneous electrical stimulation via multipole electrodes, and contacts feature in accordance with localiza what their affected areas of the nervous system, to be activated, and the modes of electrical stimulation is adjusted individually for each contact, depending on the initial state of the corresponding area activated region before each session to receive the impact of a weak electrical impulses adequate currents of the Central nervous system, taking into account the dynamics of the situation damaged functions, while electrical stimulation is carried out feeding on each contact series packs bipolar rectangular pulses with a voltage of (2÷12), the pulse repetition rate (10÷20) Hz, the duration of phase 5 MS, the number of pulses per bundle 2÷7, number series 2÷7, the duration of the series (70÷90) with an interval between packets (1÷2), the pause between the series (1-1,5) minutes

The disadvantages of the known methods are their low efficiency, due, primarily, to the fact that the application of drugs to the skin (as in the description of the method according to patent No. 2316334) only a small part of the active substance penetrates deep into the tissues of the body, particularly in the nerve (depending on the depth of its passage) comes less than 1-3% of the drugs that is not enough to stimulate the regeneration of nerve fibers.

In addition, percutaneous stimulation (as described in the abstract to the application No. 2001102533) has a much less pronounced effect than recommended way intraneural introduction electricity is W, since the skin and deep tissues are a powerful barrier to electric current.

Patent-pending method to restore sensorimotor function of the Central nervous system and peripheral nerves is an alternative therapeutic and surgical treatment of the ineffectiveness of the latter.

The technical result achieved when using patent-pending way, a high efficiency of treatment in case of defeat to 90% of the nerve synapses, allowing to achieve full recovery of the patient and reduce recovery time, as well as the possibility of outpatient treatment and the absence of contraindications.

The claimed technical result is achieved due to the implementation of the method of recovery of sensorimotor functions of the Central nervous system and peripheral nerves, namely, that the treatment is carried out in three stages, the first of which carry out the implantation of the nerve, at least two hollow electrodes from biologically neutral electrically conductive material (for example, based alloy alloy steel) proximal and distal (above and below) nerve damage; the second stage is conducted at least one course focused extracorporeal shock wave therapy consisting of at least five sessions in combination with intron Braley electrostimulation and intraneural by iontophoresis, aimed at stimulating the growth of axons in the peripheral nerve fibers and the regeneration of forming the myelin sheath Schwann cells (at this stage the formation of new synapses of the peripheral nerves); the third phase is extracted implanted electrodes and apply at least one session percutaneous electrostimulation with simultaneous electrokinetograph to coordinate the passage of nanoemulsion through newly formed synapses of the peripheral nerves.

The hollow electrodes are usually made of a biologically neutral electrically conductive material, the most frequently used alloys alloy steel. As electrodes can be used catheters for spinal tap.

The main difference patentable method of recovery of sensorimotor functions of the Central nervous system and peripheral nerves from other well-known methods is controlled rapid regeneration of neurons in enriched nutrient medium inside the damaged nerve that allows you to achieve rapid and uniform growth of axons towards each other with simultaneous synchronization mapping interceptions Ranvier (mapping of nerve synapses), and consequently, the creation of conditions for full recovery of sensory and motor functions are not the VA.

Complex therapy at the first stage of treatment involves the implantation of the nerve of two or more hollow electrodes (the number is usually determined by the length of the defect of the nervous tissue based on 2 electrode for every 5-6 cm damaged nerve) in the form of a needle above and below the set point of fault. This manipulation is performed under aseptic conditions - small operating room or treatment room. In that case, if you have an open wound surface, convenient to carry out the invasion of the electrodes under visual control, otherwise, the implantation is performed under ultrasound images. The electrodes should be entered in the nerve at a depth of 0.5-1 cm and commit to the skin two or three stitches nylon filament, followed by processing the surface of the skin around the electrode antibiotic ointment (e.g., 3% syntomycin) and closure sterile adhesive antibacterial napkin.

Through the fixed hollow electrodes is injected through the drip with software running directly into the nerve of the drug solution, with simultaneous connection device for electrical stimulation and drug iontophoresis. Hollow electrodes remain in the body of the patient during the entire course of therapy. The success of the first phase of treatment is determined by the results of the second ultrasound images affected the CSOs nerve, to determine the correctness of the invasion of the electrodes.

In the second stage of treatment using at least one course focused extracorporeal shock wave therapy, consisting of five to 20 sessions, in combination with intraneural electrical stimulation and iontophoresis, aimed at stimulating growth of axons in the peripheral nerve fibers and the regeneration of forming the myelin sheath Schwann cells. The number of sessions selected depending on the results of the readings electroneuromyography. The course continues until, still growing from session to session positive dynamics on the affected nerve electrical pulse.

Method focused extracorporeal shock wave therapy (method F SWT) is based on a short (0.1 to 0.3 seconds) the application to the field of disease-focused low-frequency impact sound waves. F-SWT dramatically improves local blood circulation and loosens the fibrous lesions, preventing the normal reunion damaged axons of nerve cells. One of the most important effects of the shock wave is to stimulate the development of new microvascular in problem areas. Theoretical aspects F-SWT is based on the creation of a shock wave with a high flux density, which focuses on restricted the th target area. This is to ensure that the shock wave will develop full energy only in the selected treatment area without damaging the surrounding tissues. Hyperbaric effect F-SWT is based on the ability of the acoustic vibration to form the micro-cavities in the tissues as a result of transition of a liquid into a gas and release it outside. Stabilization of the microcirculation around cavities: F-SWT produces micro-massage, which is very important in the treatment of edema. In the acute phase of the inflammatory process of the shock wave helps to remove histamine from the tissues and prevent the formation of other risk factors in the cells, due to increased diffusion of calcium ions through the cell membrane. The result of this process is to reduce the intensity of inflammation in the tissues. In the granulation phase of the inflammatory process stimulated the formation of neurons and fibroblasts for collagen system and a new capillary network. Thus, the different effects produced on the tissue, stimulate the healing process due to intensification of metabolic process that is used in the cases observed in neurosurgical practice in the treatment of paresis and paralysis of the peripheral nervous system, postoperative complications, neuralgia, neuropathy, etc.

The amount of energy radiated is usually classified in the Arno-wave therapy (SWT) on the low-energy (up to 1-2 MPa, is mainly used to perform physical therapy procedures), sredneperesechennoy (3-5 MPa, is used to treat muscular-ligamentous apparatus), high energy (up to 10-15 MPa, is used for treatment of protrusions and hernias of intervertebral disks) and ultra high power (15 MPa and above, used for the destruction of kidney stones and gall bladder). The parameters determining the success of extracorporeal therapy are mainly the energy and energy flux density. In order to achieve a noticeable effect in the tissue, the energy of the shock wave should be focused on just a limited target area, where it will exceed the threshold and produce a therapeutic effect.

In the patented method of recovery of sensorimotor functions of the Central nervous system and peripheral nerves focused extracorporeal shock wave therapy is carried out with the threshold energy value selected from a range of 1-5 MPa. The energy flux density is set by the machine settings during the session F-SWT, and the pulse frequency (from 1 to 5 Hz) is determined by the doctor depending on the dynamics of the effectiveness of therapy. If the patient starts to feel pain even when properly focused flow, shock waves, it is necessary to reduce their energy is Gia 0.5-1 MPa. You can also lower the frequency of 1-2 Hz. These values of frequency and energy are featured, which is achieved most pronounced effect of therapy to the patient's normal body. These values can be changed depending on specific circumstances, for example when treating children and patients with asthenic by adding these values will be less, and in obese patients or athletes, respectively.

To achieve the maximum effect of wave penetration into the tissues of the body, it is desirable to use gel conductors, such as conductive gel for ultrasonic therapy/diagnosis. The head of the emitter F-SWT pressed tightly to the surface of the skin, slowly moving so that the focus of the radiation always remained focused in the area of the lesion of the nerve.

Electrophoresis of drugs (medicinal electrophoresis) is moving in an electric field suspended in a liquid, particles, molecules. In physical therapy is a method of introduction into the organism of medicinal substances through a constant electric current through the skin or mucous membranes. In the case of the use of interstitial (intraneural) electrophoresis electrodes and medicinal substances are injected directly into the affected tissue (nerve)inside the to the which also distributed through a constant electric current. This has the combined effect of a constant electric current and medicinal substance, and therefore this method is referred to electropharmacological treatment method.

Medicinal electrophoresis based on a combination of the physiological action of the galvanic current in combination with other medicines. In General, this mechanism can be represented as follows: pain gate effect on A-Delta (fast) and S (slow) pain fibers in the posterior horns of the spinal cord as a result of stimulation of mechanoreceptors (A-beta) fibers high-frequency low-intensity electric current in combination with a selected drugs produce morphine-like effect on C-fiber system for the production of encephalin minervini stimulation of A-Delta fibers (pain receptors), resulting in a change in ion balance around cells, accelerates the healing of skin wounds and bones, recovering fibrous tissue, increases cellular metabolism and restores the potential of cell membranes increases microcirculation.

Medicinal electrophoresis is not reduced to a simple summation of the effects of galvanic current and medicinal substances. As a result of their interaction increases the impact of each of these factors, the result has been new in the action. The response depends primarily on the pharmacological properties of medicinal substances. When superficial pathological processes by electrophoresis it is possible to create a sufficiently high concentration of drugs directly into the lesion, not saturating the organism.

In the patented method of recovery of sensorimotor functions of the Central nervous system and peripheral nerves of the medicinal solution is injected in equal quantity 4 ml through established at the first stage of treatment of the hollow electrodes directly into the affected nerve. The composition of the solution includes the following products: Placenta compositum 2.2 ml, Objective T 2.2 ml, Midokalm 1 ml, Diprospan 0.25 ml, Lidocaine 2,2 ml

The composition of the medicinal solution is a special case and does not limit the invention being patented as a drug solution can be used any compound which is selected depending on local conditions, work experience and preference of the treating physician. The solution should be injected directly into the nerve, followed by iontophoresis procedure.

Intraneural electrical stimulation - a method of electric shocks on the neuromuscular apparatus. When carrying out the electrical stimulation used constant in the direction of the pulsed electric current of low voltage (6080) and low power (up to 50 mA), pulses of different shape and length. Because of the rapid rise of the current processes of diffusion and osmosis do not have time to compensate for the disruption of the ionic concentration in the tissues. These violations greater than when the effect of galvanic current of the same strength. Basic physiological reactions and therapeutic action: there are marked irritant effect of pulsed electric current. The response to this irritation - reducing muscle fibers. At the moment the circuit contraction of muscle under the cathode occurs at a lower amperage than under the anode. Healthy muscle gives this living lightning cuts. The initiation of the activity of the muscles pulsed electric shock, prevents the progression of reactions rebirth, preserves muscle to the period of reinnervation is detected. When electrical stimulation is also accelerated and restoration of damaged nerve fibers. During the procedure of stimulation of two or more electrodes fixed to the proximal (middle) or the distal (far) plots of selected muscles.

In the patented method of recovery of sensorimotor functions of the Central nervous system and peripheral nerve electrodes are inserted to a depth of 0.5-1 cm directly into the affected nerve, and by opening to the skin surface areas of the electrodes pricipled the wire apparatus electromyostimulation, which variable-vector mode is served bipolar modulation current (6, 15-20 mA, 25-50 Hz)- this allows you to evenly distribute the product throughout the area of the nerve between the two electrodes. Procedure duration is 45 minutes.

The success of the second phase of therapy is determined by the results of electrokinetograph, which is held every fifth treatment session. The criterion for completion of the second phase is to achieve the lower limit of the conduction of impulses according to standard tables of electrokinetograph (AMNH).

In the third stage of treatment from 1 to 10 sessions of percutaneous electrostimulation with simultaneous electrokinetograph to coordinate the passage of nanoemulsion through newly formed synapses of the peripheral nerves. Normal data AMNH each muscle group should correspond to the conductivity innerviruemogo their nerve bundle.

The described method of recovery of sensorimotor functions of the Central nervous system and peripheral nerves has extremely high efficiency even in case of defeat to 90% of the nerve synapses, when fail any other methods of surgical and conservative treatment. According to statistics obtained by the Israeli clinic Pain Clinic Unique methods of medical treatment" no results 15-year-old who was struggling doing more than 5000 patients with various neurological disorders, the effectiveness of the treatment method of recovery of sensorimotor function of peripheral nerves is close to 100% clinically and laboratory confirmed positive result.

The number of damaged nerve synapses before treatment, %The number of recovered nerve synapses after treatment, %
1. 201. More than 95
2. From 20 to 402. 90-95
3. From 40 to 603. 80-90
4. From 60 to 804. 60-80
5. From 80 to 905. Over 50
*According to the statistical data received "Pain Clinic Unique methods of medical treatment"

To illustrate the above material, you can consider several cases of successful application of the method of recovery of sensorimotor functions of the Central nervous system and peripheral nerves for example patients, "International Medical Center for treatment of grave pathologies op is RNO musculoskeletal system" ("IMC ODE") and the medical center "dawn", Federal state unitary enterprise "GKNPTs them. Center"

Patient, 26 years. Complaints about the lack of voluntary movement and sensation in the lower extremities, impaired urination and defecation.

Medical history: 7 years ago got a spine fracture due to falls from a height and subsequent damage to the spinal cord. Had surgery in the Institute Burdenko with subsequent courses of rehabilitation center "Overcoming" without positive dynamics.

Neurological status: active movement in the legs is missing, the muscle tone is increased in spastic type, gipostesia by conduction type.

On AMNG: When analyzing the conductive function of the peroneal and tibial nerves were not revealed normal levels of the SRV. When conducting CBT with the abstraction of responses from the muscles of the foot is not received reliable playback induced motor response.

CONCLUSION: the paralysis of the lower limbs

Diagnosis: Traumatic spinal injuries, post operative intervention. Paralysis of the lower extremities. Dysfunction of the pelvic organs.

Were treated, namely, that the patient had been implanted at the nerve of two hollow electrodes from biologically neutral electrically conductive material proximal to and distal to the injury of the nerve, then performed one course focused is Oh extracorporeal shock wave therapy, consisting of six sessions in conjunction with intraneural electrostimulation and intraneural by iontophoresis, aimed at stimulating growth of axons in the peripheral nerve fibers and the regeneration of forming the myelin sheath Schwann cells. Through hollow electrodes directly into the nerve drip injected drug solution containing Placenta compositum - 2.2 ml, Objective T - 2.2 ml, Midokalm 1 ml, Diprospan - 0.25 ml, Lidocaine - 2.2 ml and simultaneously conducted electrical stimulation and drug iontophoresis.

Shock wave therapy was performed at the energy value, equal to 5 MPa, and the pulse frequency of 4 Hz. After this was removed implanted electrodes and conducted five sessions of percutaneous electrostimulation with simultaneous electrokinetograph to coordinate the passage of nanoemulsion through newly formed synapses of the peripheral nerves.

Neurological status after completion of the last course: active and passive motion has recovered almost fully, muscle tone normal, remains moderate muscle atrophy

On the control AMNG: compared with the previous study, a clear positive trend. Data analysis studies in the dynamics indicates a marked decrease newsegments (above segment T5) influences on re is ulatio movements and muscle tone of the lower extremities. To a much lesser extent saved the signs of lesions of the peroneal nerve, the sensory fibers of the gastrocnemius nerve on both sides. The type of nerve injury is predominantly axonal.

CONCLUSION: EMG signs of spinal stenosis of the thoracic spine without symptoms of paralysis of the lower limbs.

The patient And society, 35 years. Complaints sharply limited range of motion and sensation in the lower limbs

Medical history: 5 years ago the patient underwent purulent meningitis, due to complications which developed persistent paraplegia of the lower extremities. Had surgery to remove molten purulent content area of the spinal cord in the thoracic spine (T10-T11) without positive dynamics.

Neurological status: active movement in the legs is restricted, moved around the house on crutches, on the street in a wheelchair. Muscle tone decreased in atrophic type, gipostesia by conduction type.

On AMNG: F-waves on the left peroneal nerve are not registered, right peroneal nerve, their number reduced to 15-20%. Increasing tahitipresse on the left tibial nerve, privatest F-waves in the right tibial nerve.

CONCLUSION: newsegment defeat of motor control and muscle tone of the lower extremities, canalino dem is ioniziruushei the defeat of the motor fibers of both peroneal nerves. Paraplegia of the lower extremities, more to the left.

Diagnosis: Degenerative-dystrophic lesions of the spinal cord, a condition after surgery. Paraplegia of the lower extremities.

Were treated, namely, that the patient had been implanted at the nerve of the four hollow electrodes from biologically neutral electrically conductive material proximal to and distal to the injury of the nerve, and then conducted two courses focused extracorporeal shock wave therapy, each of the courses consisted of thirty sessions, courses conducted in conjunction with intraneural electrostimulation and intraneural by iontophoresis, aimed at stimulating growth of axons in the peripheral nerve fibers and the regeneration of forming the myelin sheath Schwann cells. Through hollow electrodes directly into the nerve drip injected drug solution containing Placenta compositum - 2.2 ml, Objective T - 2.2 ml, Midokalm 1 ml, Diprospan - 0.25 ml, Lidocaine - 2.2 ml and simultaneously conducted electrical stimulation and drug iontophoresis.

Shock wave therapy was performed at the energy value, equal to 5 MPa, and the pulse frequency of 5 Hz. After this was removed implanted electrodes and conducted one session percutaneous electrostimulation with simultaneous electronion what iographies to coordinate the passage of nanoemulsion through newly formed synapses of the peripheral nerves.

Neurological status after treatment: active and passive movement was restored to the right full, left almost in full, muscle tone normal. The patient themselves out on the street, floats, engaged in dancing on the individual program. Recommended another course of treatment to eliminate residual effects of paraplegia.

On the control AMNG: Analysis of research data in dynamics indicates a significant decrease newsegments influences on the regulation of movement and muscle tone of the lower extremities. Decreased the degree of demyelination of motor nerves on the right and left. The degree newsegments effects on muscle tone on the right and on the left was korrelirovalisj. F-waves on the left peroneal nerve are recorded in the amount of 80-85% (not previously reported), on the right peroneal nerve in full (previously 15-20%). Tibial nerves on both sides without pathology. In the calf muscles is dominated by the processes of reinnervation.

CONCLUSION: a clear positive trend, more pronounced on the right. Is a minor decrease in muscle strength in the left lower extremity. The diagnosis of paraplegia in history.

The patient With s, 24 years. Complaints about the complete lack of movement and sensation from the chest down. Dysfunction of the organs of the pelvis.

The history of Soboleva who I am: 5 years ago he received a gunshot wound of the thoracic spine (T2-T3), as a result of which he developed paralysis of the lower extremities. The patient underwent 3 operations for removing the bullet and bone fragments, the mapping of the vertebral bodies and the reunification of the integrity of the spinal cord, not affecting the status neurological status.

Neurological status: active movement in the legs is missing, the control function of the pelvis is missing.

On AMNG: When you register with the lead with the leg muscles (muscles of the hips, and feet) on both sides of response is not received, indicating a full block on corticospinal tract from the level of traumatic injuries of the spine and spinal cord.

Diagnosis: Traumatic spinal injuries, post operative intervention. Paralysis of the lower extremities. Dysfunction of the pelvic organs.

Were treated, namely, that the patient had been implanted at the nerve of the four hollow electrodes from biologically neutral electrically conductive material proximal to and distal to the injury of the nerve, then made nine courses focused extracorporeal shock wave therapy, each of the courses consisted of thirty sessions, courses conducted in conjunction with intraneural electrostimulation and intraneural by iontophoresis, aimed at stimuleren is the growth of axons in the peripheral nerve fibers and the regeneration of forming the myelin sheath Schwann cells. Through hollow electrodes directly into the nerve drip injected drug solution containing Placenta compositum - 2.2 ml, Objective T - 2.2 ml, Midokalm 1 ml, Diprospan - 0.25 ml, Lidocaine - 2.2 ml and simultaneously conducted electrical stimulation and drug iontophoresis.

Shock wave therapy was performed at the energy value, equal to 2 MPa, and the pulse frequency of 3 Hz. After this was removed implanted electrodes and conducted two sessions of percutaneous electrostimulation with simultaneous electrokinetograph to coordinate the passage of nanoemulsion through newly formed synapses of the peripheral nerves.

Neurological Statute after completion of the last course: Active and passive movements of the lower limbs recovered in necessary self-service volume, muscle tone normal, saved muscular atrophy. The control function of the pelvic organs recovered fully. The wife of the patient, the child was born as the result of pregnancy in a natural way.

On the control AMNG: peroneal nerve on the right - M-response was reduced to 2.1 mV at the rate of 3.0 mV (previously no response), the tibial nerve on the right - M-response of 5.1 mV at a rate of 5 mV (previously no answer). Sural nerve is a sensory amplitude response 28 µv (previously no answer). Needle electrodes in the front is great the Shin muscle, calf muscle and General short extensor of the toes alone spontaneous activity no recruitment of PDE there.

CONCLUSION: the Revealed changes indicate the minimum secondary axonal changes, in General, a conductive function of motor and sensory fibers are not broken, the excitability of motoneurons in the lumbar segments slightly reduced. Diagnosis: paralysis of the lower limbs in history.

The patient Islands, 56 years. Complaints of muscle weakness and decreased sensation in the right foot.

Medical history: For over 10 years suffering from the effects of surgery on the spine about discectomy L4-L5. Annually courses sanatorium-resort treatment with physical therapy, mud therapy, massages without positive dynamics.

Neurological status: Volume of active movements restricted in his right leg, muscular strength is lowered. Muscle tone is changed according to the type of hypertonicity, superficial and deep sensitivity of the right leg is lowered. Syndromes tension Neri and Lasaga positive to the right. The symptom of "tripod".

On AMNG: F-waves in the right peroneal nerve is reduced to 75-80%, privatest F-waves in the right tibial nerve.

CONCLUSION: newsegment defeat of the right sciatic nerve

Diagnosis: post-operative damage to the spine of the rights of the th of the sciatic nerve. Monoplegia of the right lower limb.

Were treated, namely, that the patient had been implanted at the nerve of five hollow electrodes from biologically neutral electrically conductive material proximal to and distal to the injury of the nerve, then performed one course focused extracorporeal shock wave therapy, consisting of five sessions in conjunction with intraneural electrostimulation and intraneural by iontophoresis, aimed at stimulating growth of axons in the peripheral nerve fibers and the regeneration of forming the myelin sheath Schwann cells. Shock wave therapy was performed at the energy value equal to 3 MPa, and the pulse frequency of 2 Hz. After this was removed implanted electrodes and conducted one session percutaneous electrostimulation with simultaneous electrokinetograph to coordinate the passage of nanoemulsion through newly formed synapses of the peripheral nerves.

Neurological status after treatment: active and passive movement of the right leg has recovered in full, muscle tone normal.

On the control AMNG: F-waves in the right peroneal nerve are recorded in the amount close to 100% (previously 75-80%).

CONCLUSION: the full recovery of the right sciatic nerve.

yagnas at discharge - monoplegia in history.

Patient f-VA, age 37. Complaints about frequent urination (up to 15-20 revolution day)

Medical history: 3 years ago suffered a fall from skis, owing to what happened compression fracture of the 4th lumbar vertebra. A few days after the fall, the patient reported increased urge to urinate. Address to the urologist and assigned a course of antibiotic and anti-inflammatory therapy effect to no avail.

Neurological status: Neurology status: active movement in the limbs saved, pathological reflexly is not detected, the sensitivity of the skin of the small pelvis and inner thighs disturbed by type of giperstesia.

On AMNG: dermal registration saw an increase in the speed of conduction of the impulse that demonstrates the interest of the lumbosacral nerve plexus.

The diagnosis of overactive bladder

Were treated, namely, that the patient had been implanted at the lumbosacral nerve plexus five hollow electrodes from biologically neutral electrically conductive material proximal to and distal to the injury of the nerve, then performed one course focused extracorporeal shock wave therapy, consisting of five sessions in conjunction with in aneuretinae electrostimulation and intraneural by iontophoresis, aimed at stimulating the growth of axons in the peripheral nerve fibers and the regeneration of forming the myelin sheath Schwann cells. Through hollow electrodes directly into the nerve drip injected drug solution containing: Placenta compositum - 2.2 ml, Midokalm 1 ml, Lidocaine - 2.2 ml and simultaneously conducted electrical stimulation and drug iontophoresis.

Shock wave therapy was performed at the energy value, equal to 6 MPa, and the pulse frequency of 8 Hz. After this was removed implanted electrodes and conducted one session percutaneous electrostimulation with simultaneous electrokinetograph to coordinate the passage of nanoemulsion through newly formed synapses of the peripheral nerves.

Neurological status after treatment: Normalized urination (4-5 times a day).

On the control AMNG: Without pathology.

Diagnosis at discharge - Overactive bladder in history.

The patient, 76 years of age. Complaints of weakness in his right hand, the fingers of the right hand.

Medical history: Considers himself ill for over 40 years, when the electric discharge when conducting electrical work almost ceased to act right hand.

Neurological status: Volume of active movements severely restricted in his right hand, myshechnaya reduced. Muscle tone is changed according to the type of gipotonus, superficial and deep sensitivity right hand lowered.

On AMNG: N. radialis - m. flex carpi radialis dex: Latency (terminal latency) of 6.75 ms (normal less than 4.8 ms) Amplitude (the amplitude of the M-response) of 0.2 mV (norm more than 3.5 mV) Velocity (the velocity of propagation of excitation) 13 m/s (the rate of more than 40 ms).

N. ulnaris - m. flex carpi ulnaris dex: Latency (terminal latency) of 13.75 ms (normal minimum of 5.1 ms) Amplitude (the amplitude of the M-response) of 0.7 mV (norm more than 3.5 mV) Velocity (the velocity of propagation of excitation) 21 m/s (the rate of more than 40 ms).

R cutaneus antebrachii medialis - Arm: Latency (terminal latency) of 7.75 ms (normal less than 4,1 ms) Amplitude (the amplitude of the M-response) of 1.7 mV (norm more than 5 mV) Velocity (the velocity of propagation of excitation) 11 m/s (normal 45 ms).

R cutaneus antebrachii lateralis - Arm: Latency (terminal latency) of 9.75 ms (normal less than 4,1 ms) Amplitude (the amplitude of the M-response) of 2.3 mV (norm more than 5 mV) Velocity (the velocity of propagation of excitation) 16 m/s (normal 45 ms).

R cutaneus antebrachii posterior - Arm: Latency (terminal latency) of 7.75 ms (normal less than 4,1 ms) Amplitude (the amplitude of the M-response) of 1.7 mV (norm more than 5 mV) Velocity (the velocity of propagation of excitation) 21 m/s (normal 45 ms).

R cutaneus antebrachii posterior - Arm: Latency (terminal latency) cent to 8.85 ms (normal less than 4,1 ms) Amplitude (the amplitude of the M-response) of 1.7 mV (norm more than 5 mV).

Diagnosis: monopoles right hand.

Were treated, namely, that the patient produced by the led implantation in the five nerve hollow electrodes from biologically neutral electrically conductive material proximal to and distal to the injury of the nerve, then he made four courses focused extracorporeal shock wave therapy, consisting of twenty sessions in conjunction with intraneural electrostimulation and intraneural by iontophoresis, aimed at stimulating growth of axons in the peripheral nerve fibers and the regeneration of forming the myelin sheath Schwann cells. Through hollow electrodes directly into the nerve drip injected drug solution containing Placenta compositum - 2.2 ml, Objective T - 2.2 ml, Midokalm 1 ml, Diprospan - 0.25 ml, Lidocaine - 2.2 ml and simultaneously conducted electrical stimulation and drug iontophoresis.

Shock wave therapy was performed at the energy value, equal to 0.8 MPa, and the pulse frequency of 0.6 Hz. After this was removed implanted electrodes and conducted ten sessions of percutaneous electrostimulation with simultaneous electrokinetograph to coordinate the passage of nanoemulsion through newly formed synapses of the peripheral nerves.

Neurological status after treatment: the function of the right hand was completely restored.

On the control AMNG: N. radialis - m. flex carpi radialis dex: Latency (terminal latency) 4,55 ms (normal less than 4.8 ms) Amplitude (the amplitude of the M-response) of 3.6 mV (norm more than 3.5 mV) Velocity (the velocity of propagation of excitation) 33 m/s (the rate of more than 40 ms).

N. ulnaris - m. flex carpi ulnaris dex: Latency (t is renalka latency) of 7.25 ms (normal minimum of 5.1 ms) Amplitude (the amplitude of the M-response) of 3.6 mV (norm more than 3.5 mV) Velocity (the velocity of propagation of excitation) 43 m/s (the rate of more than 40 ms).

R cutaneus antebrachii medialis - Arm: Latency (terminal latency) 2,95 ms (normal less than 4,1 ms) Amplitude (the amplitude of the M-response) of 6.6 mV (norm more than 5 mV) Velocity (the velocity of propagation of excitation) 41 m/s (normal 45 ms).

R cutaneus antebrachii lateralis - Arm: Latency (terminal latency) of 2.75 ms (normal less than 4,1 ms) Amplitude (the amplitude of the M-response) of 7.5 mV (norm more than 5 mV) Velocity (the velocity of propagation of excitation) 42 m/s (normal 45 ms).

R cutaneus antebrachii posterior - Arm: Latency (terminal latency) 4,15 ms (normal less than 4,1 ms) Amplitude (the amplitude of the M-response) of 5.6 mV (norm more than 5 mV) Velocity (the velocity of propagation of excitation) 51 m/s (normal 45 ms).

R cutaneus antebrachii posterior - Arm: Latency (terminal latency) of 5.25 ms (normal less than 4,1 ms) Amplitude (the amplitude of the M-response) of 4.9 mV (norm more than 5 mV).

Conclusion: minor violations of excitability and conductivity of the nerves of the right hand, in General, not beyond the upper limit.

Diagnosis at discharge - monoplegia in history.

1. Method of recovery of sensorimotor functions of the Central nervous system and peripheral nerves, namely, that the treatment is carried out in three stages, the first of which carry out the implantation of the nerve, at least two hollow electrodes from biologically neutral electrically conductive material proximal to and distal to the injury of the nerve, the second stage is carried out at least one course SFD is Pirovano extracorporeal shock wave therapy, consisting of at least five sessions, in combination with intraneural electrostimulation and intraneural by iontophoresis, aimed at stimulating growth of axons in the peripheral nerve fibers and the regeneration of forming the myelin sheath Schwann cells, in the third stage, remove the implanted electrodes and apply at least one session percutaneous electrostimulation with simultaneous electrokinetograph to coordinate the passage of nanoemulsion through newly formed synapses of the peripheral nerves.

2. The method according to claim 1, namely, that as hollow electrodes used catheters for spinal tap.

3. The method according to claim 2, consisting in that the hollow electrodes are injected into the nerve at a depth of 0.5 to 1 cm and fixed to the skin two or three stitches nylon thread.

4. The method according to claim 3, which consists in the fact that the hollow electrodes are implanted from the calculation of the two electrodes at every 5-6 cm damaged nerve above and below the installed location of the damage.

5. The method according to claim 4, namely, that through the hollow electrodes directly into the nerve is injected through the drip with software control of the medicinal solution and simultaneously conduct the electrical stimulation and drug iontophoresis.

6. The method according to claim 5, which consists in the fact that lekarstvennyye introduced in equal number by 4 ml.

7. The method according to claim 5, which consists in the fact that it goes on the skin surface areas of the hollow electrodes attached wire apparatus electromyostimulation that in the variable-vector mode serves bipolar modulated current.

8. The method according to claim 5, which consists in the fact that the drug solution includes Placenta compositum 2.2 ml, Objective 2.2 ml, Midokalm 1 ml, Diprospan 0.25 ml, Lidocaine 2,2 ml

9. The method according to claim 1, namely, that focused extracorporeal shock wave therapy is carried out with the threshold energy value selected from a range of 1-5 MPa.



 

Same patents:

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutics, namely a method for preparing and purifying monosialoganglioside GM1. The method for preparing pure monosialoganglioside GM1 in the form of its sodium salt involves (a) GM1 separation from Fucosyl GM1 in a lipid mixture containing monosialoganglioside GM1 as a main ganglioside component by a column ion-exchange chromatography using an eluent comprising potassium or cesium ions, (b) recovery of the dissolved substance from the eluted solution, (c) diafiltration of the aqueous solution of the recovered dissolved substance of the stage (b), (d) addition of sodium salt, and diafiltration of the prepared aqueous solution (d) recovery of GM1 in the form of its sodium salt. The method for purifying monosialoganglioside GM1 from Fucosyl GM1 in the lipid mixture, the column ion-exchange chromatography using the eluent comprising potassium or cesium ions. The preparation of monosialoganglioside GM1 has a purity of 99.0% or more, and contains less than 0.1% of Fucosyl GM1. The method of treating disorders and diseases of the central nervous system and the peripheral nervous system, comprising administering the preparation of monosialoganglioside GM1 to the patient in its effective amount. The use of the preparation of monosialoganglioside GM1 in preparing a pharmaceutical composition.

EFFECT: use the above preparation of monosialoganglioside GM1 in treating has the considerable advantages due to reducing side effects.

17 cl, 1 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to pediatric neurology, and can be used for rehabilitation of neurological disorders in children in case of neuroinfections. For this purpose, at the background of adequate complex and pathogenetic therapy, parenteral introduction of actovegin in acute period of disease additionally from the first days of disease cytoflavin is introduced intravenously by drop infusion in dose 0.6 ml/kg or 10 ml per day for 3-5 days, elcar perorally in dose 70-100 mg/kg of weight per day for 3-4 weeks. In the period of early reconvalescence pantogam is additionally introduced perorally in dose 50-70 mg/kg of weight per day for 4 weeks. In case if multifocal affection of brain substance is present, gliatilin is introduced intravenously by drop infusion in dose 1 ml per 5 kg of body weight per day in combination with intramuscular introduction of ipidacrine in dose 5-15 mg per day for 7-10 days, after that gliatilin perorally in dose 50 mg/kg of weight per day together with ipidacrine inside in dose 1 mg/kg per day for 4 weeks.

EFFECT: method makes it possible to improve disease outcome due to reduction of frequency of residual neurological deficiency formation with reduction of term of hospital treatment.

3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed invention relates to field of pharmacology and clinical medicine and describes pharmaceutical compositions of 2-amino-2-[2-(4-octylphenyl)ethyl]propan-1,3-diole in free form and/or in form of pharmaceutically acceptable salt, where as auxiliary substances they contain lactose, starch and/or starch derivatives, selected from acetylated starch, sodium salt of starch carboxymethyl ether, pregelatinised starch, sodium starch glycolate, gelatin, binding agent, and lubricant with specified ratio.

EFFECT: invention makes it possible to extend possibility for cheaper in industrial manufacturing preparation for treatment of disseminated sclerosis.

7 cl, 16 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to neurology, restorative medicine, and can be applied in treatment of consequences of infantile cerebral paralysis. For this purpose reflex low temperature impact on nerve plexuses of peripheral artery is performed. Said impact is performed first in lower third of forearm, and after three months in first interdigital space of foot. Cryoapplicator with diameter 2 mm is installed on exposed peripheral artery and double cryogenic impact with duration 10 seconds is performed at temperature minus 186°C. In the period between low temperature impacts complex drug therapy is carried out: in the first two weeks administered are detralex in dose 1 capsule 2 times per day, nicospan in dose 1 tablet 3 times; in the second two weeks grandaxin in dose 0.05 in the morning; spasgan in dose 1 tablet in the afternoon; atarax in dose 1/2 tablet before going to bed.

EFFECT: method ensures definite consistency, which makes it possible to compensate vegetative dystonia syndrome, normalise neuromuscular transmission, reduce muscle spasticity, optimise motor functions of upper and lower extremities and, therefore, improve coordination of movements and supportability of lower extremities.

1 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely neurology, and is applicable for treating lumbar radicular pain syndrome. That is ensured by single catheterisation of an epidural space, and a microinfusion pump is used for the continuous introduction of 0.2% Ropivacaine for 5-10 days at 2.0-8.0 ml/h until pain syndrome is relieved.

EFFECT: method enables an immediate therapeutic and analgesic effect with low toxicity and reduced risk of treatment-induced complications, as well as reduced length of staying in hospital with safety, inspectability and controllability.

2 cl, 1 dwg, 3 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutics and represents a pharmaceutical composition for multiple sclerosis containing Teriflunomide as an agent and excipients in the following proportions, wt %: Teriflunomide - 3.0-13.5; Lactose and/or Ludipress LCE - 48.5-65.0; Starch - 7.0-16.0; Microcrystalline cellulose and/or Hypromeloza - 20.0-30.0; Collidone VA-64 - 3.5-4.5; Magnesium stearate - 0.8-1.2; Aerosil - 0.8-1.2; Benecel MP-824 - 13.5-15.5.

EFFECT: invention provides the extended range of effective drugs for multiple sclerosis.

7 cl

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to orthopedics and neurosurgery. Electromyographic examination with making functional tests, assessing active amplitude of movements in joints, degree of arbitrary control of extremity, biomanual skills, is carried out. Data of examination are obtained before and after diagnostic blockage of median nerve with anesthetic. If amplitude of movements in joints increases, functional possibilities of extremity improve, and electrogenesis of forearm muscles reduces by more than 100 mcV, first neurosurgical treatment is performed with carrying out selective neurotomy of motor branches of median nerve. In case of insignificant impact of diagnostic blockage on examination results, first orthopedic treatment is performed.

EFFECT: method extends arsenal of means for determining type of surgical treatment of upper extremity in children with infantile cerebral paralysis.

2 dwg

FIELD: medicine.

SUBSTANCE: present invention refers to medicine, namely neurology, and may be used for treating patients with trifacial nerve neuralgia. For this purpose, perivascular fibres of radial artery and trigeminal nerve branch exit points are exposed to low-temperature reflex radiation. It is combined with two exposures of the perivascular fibres of radial artery from a miniapproach in a lower one-third of forearm to a cryocautery device of a tip diameter of 2 mm for 10 seconds at temperature minus 165°C. Then, the trigeminal nerve branch exit points are locally exposed to the cryocautery device of the tip diameter of 2 mm for 30 seconds at temperature minus 160°C. Further, from the second day following the local low-temperature exposure, an integrated drug-induced therapy is prescribed. For this purpose, detralex 1 capsule is introduced twice a day, and nicoshpan is introduced 1 tablet 3 times a day for two weeks. Suture release is followed by the two-week introduction of grandaxin 0.05 in the morning, spasgan 1 tablet in the afternoon, atarax 1/2 tablets for the night.

EFFECT: method provides reducing length of treatment and number of unsatisfactory clinical outcomes with substantial compensation of pain syndrome with formation of prolonged remission of a pathological process ensured by improved peripheral blood flow and correction of vegetative disorders supporting pain syndrome.

2 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, and concerns a method for stimulating posttraumatic peripheral neurotisation in a mammal. A method consists in the fact that L-arginine is introduced in a deposit medium of carboxymethyl cellulose sodium salt used to fill a silicone tube, while the created conduit is implanted into an extended nerve rupture.

EFFECT: invention provides a manifested stimulating effect on nerve motion and sensory function recovery, effectively maintaining sensory cell survival and regenerating myelin fibre penetration from the central to peripheral nerve segment.

4 cl, 1 ex, 2 dwg

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed are: application of combination of flurpirtine and tramadol or their physiologically acceptable salts with weight ratio of flurpirtine to tramadol from 10:1 to 1:14 for pain treatment and application of the same combination for obtaining mediaction for peroral, rectal, intravenous, transcutaneous, or subcutaneous or intracutaneous introduction for pain treatment.

EFFECT: demonstrated is increased efficiency (synergism) of combination in pain treatment and unexpected "anti-vomiting" effect of flurpirtine in combination with vomiting-inducing high dose of tramadol; as well as introduction of combination results in reduction of such side effects as cramps, increased muscle tone and vomiting.

13 cl, 6 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely dentistry, and may be used for treating herpetic stomatitis in HIV-patients. That is ensured by conducting a therapy that involves anti-herpetic, analgesic and anti-inflammatory preparations. From the very beginning of the therapy, the 2-week oral administration of glyciram 0.05-0.01 g is prescribed 2-4 times a day after a meal. In addition, the oral mucosa is topically exposed to low-frequency ultrasound oscillations with amplitude of oscillation 30-35 mcm, with frequency of cavitation 24.5-28.5 kHz for the first minute through an aqueous solution of glyciram. The aqueous solution of glyciram is prepared in advance at 0.025 mg of glycyram granules per 100 ml of warm boiled water. The therapeutic course is 10-14 ultrasonic procedures.

EFFECT: method provides the increased clinical effectiveness ensured by eliminating the side effects and reducing the severity of the disease.

2 ex

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a magnetic system which has a structure containing magnetic nanosized particles of formula MIIMIII2O4, wherein MII=Fe, Co, Ni, Zn, Mn; MIII=Fe, Cr, or maghemite which are functionalized by bifunctional compounds of formula R1-(CH2)n-R2 where n = 2-20, R1 is specified in: CONHOH, CONHOR, PO(OH)2, PO(OH)(OR), COOH, COOR, SH, SR; R2 is an external group, and is specified in: OH, NH2, COOH, COOR; R is an alkyl group or an alkaline metal specified in C1-6-alkyl and K, Na or Li, respectively). The structure also includes a polymer optionally containing a pharmacologically active molecule, and an external pharmacologically active molecule may be specified in anticancer agents, antimicrobial agents, anti-inflammatory agents, immunomodulators, molecules acting on the central nervous system or able to mark cells so as to enable the identification thereof by means of the usual diagnostic detectors. The invention also refers to a method for preparing the nanosized particles of formula MIIMIII2O4 which consists in adding a metal salt to alcohol, heating to complete solubilisation of salts, adding water to facilitate salt hydrolysis and heating to temperature 150-180°C to prepare a suspension to be then functionalised. The invention also refers to a method for preparing the magnetic system, wherein the functionalised nanoparticles and the pharmacologically active molecules are integrated into the matrix of a water-insoluble polymer, and the prepared structure is continuously and one-stage coated with adequate surfactants.

EFFECT: invention aims at preparing the magnetic system suitable for hyperthermia procedures.

16 cl, 4 tbl, 1 dwg, 26 ex

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to urology and may be used for treating chronic abacterial prostatitis. The treatment involves rectal phonophoresis daily within the therapeutic course of 10 procedures. Before phonophoresis, 60% aqueous Tisol 14 ml containing dissolved diclofenac 100 mg is introduced as a drug preparation into the patient in a knee-elbow position. It is added with 2-minute prostate massage, 3-minute rectal phonophoresis followed by one-hour pronation.

EFFECT: method provides the effective treatment ensured by reduced obstruction and irritation symptoms, pain syndrome management, prolonged remission, improved urofluometry, total score of the prostatic disease, quality of life index, as well as patients' libido.

2 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely physiotherapy. A method involves hardener injections and local vibroacoustic impact. The vibroacoustic impact immediately follows the hardener injections. The impact frequency range is 0.33 kHz. The impact sequentially covers each section of the sclerosis vein. Length of the session is 3 minutes.

EFFECT: method reduces a rehabilitation period, a number of remote complications with a smaller amount of detergent preparations.

3 tbl

FIELD: medicine.

SUBSTANCE: invention refers to medical equipment, particularly to apparatuses for treating upper extremity lymphedema. The apparatus comprises a movable carrier, an instrument box with a control unit, a two-side open polymeric heat chamber with two sealers coupled with a shape-generating perforated polymer frame connected with a bearing polymer perforated lodgement, a waste ozone/NO air mixture deactivator, a temperature sensor, a coolant generator, an ozone/NO air mixture generator, a low-frequency ultrasonic vibration generator with acoustic assemblies and instrument waveguides. The heat chamber is equipped with an outlet branch; one end of the chamber is fixed by an elastic sealer on an output flange of the instrument box installed on a tray of the movable carrier and pivotally connected with the lodgement. A bearing transverse bar with a massage instrument in the form of a freely rotating roller from a massage ring set is height-movable and locked, and console-connected to a holder mounted on one side of the movable carrier. A thermally and photochrome-ultrasound applicator is connected to a power supply of the instrument box one output of which is connected to a board of a semiconductor polychromatic LED array, and the other one is connected to a vibro-pulse massage unit. Additionally, the apparatus is equipped with an open-side polymer sleeve that matches the size of the affected extremity.

EFFECT: use of the invention improves the clinical effectiveness in upper extremity lymphedema due to the use of the complex of physical factors combined with the high-activity drug substances for activating lymphatic drainage.

24 dwg, 1 tbl

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to medicine, namely to urology and may be used for treating chronic abacterial prostatitis. The treatment involves administration of a drug preparation and rectal phonophoresis daily within the therapeutic course of 10 procedures. Before phonophoresis, aqueous solution of Tisol 14 ml 60 % is introduced into the patient in a knee-elbow position. It is added with 2-minute prostate massage, 3-minute rectal phonophoresis followed by one-hour pronation.

EFFECT: method provides the effective treatment ensured by reduced obstruction and irritation symptoms, pain management relief, prolonged remission, improved urofluometry, quality of life index, as well as patients' libido.

2 ex, 1 tbl

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to surgery and traumatology, and can be applied for treatment of serous-hemorrhagic pleuritis. For this purpose, after removal of blood and exudate from pleural cavity through puncture needle into pleural cavity introduced is physiological solution with wide spectrum antibiotic, after which needle is removed from pleural cavity, after 10 minutes ultrasonic inhalation with iodide solution is carried out, after 10 minutes low-frequency magnetic therapy on chest on affected side is performed on posterior surface in the interval between scapular and midaxillary lines from 4 to 8 intercostal space.

EFFECT: method makes it possible to improve results of treatment of patients and reduce development of complications due to carrying out efficient sanitation of pleural cavity and stopping inflammation.

2 cl

FIELD: medicine.

SUBSTANCE: invention refers to medical equipment, namely to ultrasonic devices for transdermal drug delivery. A plaster contains an adhesive layer as a base layer, a directly adjoining drug layer, an ultrasonic transducer, an exciting unit and a coating layer. The drug layer, the ultrasound transducer and the exciting unit are arranged in the form of successive bottom-up layers, while the coating layer covers said three layers. A method for preparing the plaster involves the stages whereat one surface of the adhesive layer is coated with an agent with an opposite surface of the adhesive layer contains two surface areas - a first area and a second area. The adhesive layer is the lowest layer of the plaster and made of a flexible material possessing good permeability. That is followed by fixing the drug layer, the ultrasonic transducer and the exciting unit in the first area; thereafter the second area is coated with the adhesive agent and combined with the coating layer; the drug is sprayed over an adsorbent material, or the adsorbent material is impregnated with the drug to form the drug layer. The drug layer is fixed on the first surface with the surface of the ultrasonic transducer emitting ultrasonic waves being directly attached to the drug layer. A power on/off film is used to find a power source in an off position with one end of the film being open from an external side of the plaster to remove the film when in use in order to activate the power source; the drug layer, the ultrasonic transducer and the exciting unit are coated with the coating layer and fixed on the first layer by means of a part of the coating layer; another part is combined with the second area of the adhesive layer to form a freely flexing edge so that to make the plaster placed on an uneven skin surface of human body.

EFFECT: use of the invention enables higher working efficiency ensured by generating more uniform and regular ultrasonic field, as well as simplifying plaster technology.

12 cl, 6 dwg.

FIELD: medicine.

SUBSTANCE: invention refers to medical equipment, namely to tissue thermal therapy devices. The device comprises a power emitter attached to a holder, and a manipulator comprising a manipulator transmission unit incorporating a hanger body, a transmission drive unit comprising a drive element, and a holder hanged onto the hanger body. The manipulator transmission unit has a first sub-unit for moving and rotating the hanger body in a surface parallel to a support surface, as well as a second sub-unit for moving the power emitter along a focusing axis and for rotating the emitter about two various axes perpendicular to the focusing axis. The hanger body comprises remote portion; the first sub-unit comprises movably guided supports and support guides. Each of the remote portions is rotated and coupled with the movably guided support which is supported by the support guide. A magnetic resonance imager is provided with the tissue thermal therapy device.

EFFECT: use of the invention enables precise positioning and orientation of the power emitter providing five degrees of freedoms.

16 cl, 16 dwg

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely the use of ultrasound for local thermal and mechanical effect on biological tissue in ultrasound surgery. Biological tissue is exposed to focused ultrasonic bunch of high intensity within the frequency range of 0.8-2 MHz. The ultrasonic bunch is created in the form to provide minimal ultrasound ingress into thoracic bones on the bases of pre-determination of bone coordinates. What is also used is visualisation in generation of tissue boiling in an exposure centre. The exposure is conducted at ultrasonic bunch power to provide formation of short fronts in the primary focus with peak positive pressure 30-80 MPa. Local destruction is created within the arrangement of the primary focus without involving the side foci.

EFFECT: method enables reducing an focus splitting effect onto the primary and side foci after the focused ultrasound passes through a periodical rib structure.

6 cl, 5 dwg, 4 ex

FIELD: medicine.

SUBSTANCE: invention refers to medicine, in particular to methods of weight correction, and may be used for alimentary obesity. For this purpose, autonomous electrical stimulators of the gastrointestinal tract are introduced in the period of weight correction. The preparatory period involves the psychotherapeutic sessions with the electrical stimulator being placed in the patient's mouth for 3-5 days to create and enforce a psychological weight reduction set, and thereafter being swallowed by the patient. Then 2-5 days later, a diet therapy accompanied by a balanced diet is prescribed. At the final stage, the electrical stimulator is introduced once again. The method also involves the use of the electric stimulators, an anode electrode coated with a layer of microelements involved in the digestion and/or metabolism, e.g. zinc, chromium, selenium, copper, and iron.

EFFECT: method provides the effective weight reduction, including by the recovery the intestinal peristaltic function and the more reliable enforcement of a patient's psychological result set, while minimising the negative side effects of the treatment.

Up!